WO2018154585A1 - Formulation de gel et son procédé de fabrication - Google Patents

Formulation de gel et son procédé de fabrication Download PDF

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Publication number
WO2018154585A1
WO2018154585A1 PCT/IL2018/050216 IL2018050216W WO2018154585A1 WO 2018154585 A1 WO2018154585 A1 WO 2018154585A1 IL 2018050216 W IL2018050216 W IL 2018050216W WO 2018154585 A1 WO2018154585 A1 WO 2018154585A1
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WO
WIPO (PCT)
Prior art keywords
amount
dietary supplement
nutraceutical composition
vitamin
lbg
Prior art date
Application number
PCT/IL2018/050216
Other languages
English (en)
Inventor
Yoel GRINBOIM
Original Assignee
Seacret Spa Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seacret Spa Ltd. filed Critical Seacret Spa Ltd.
Publication of WO2018154585A1 publication Critical patent/WO2018154585A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/238—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A23L29/272—Gellan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates

Definitions

  • the invention is directed to a dietary supplement or a nutraceutical composition, optionally in a form of a gel comprising one or more of xanthan gum, locust bean gum (LBG) and/or gellan gum, as well as water, a nutrient supplement, a vitamin and a preservative.
  • apple sugar syrup is added to the dietary supplement or a nutraceutical composition of the invention.
  • the human body requires that all essential nutrients be adequately supplied and utilized to optimize health and well-being.
  • the human body acquires essential nutrients through the consumption of a variety of foods. Poor health may be a result of an imbalance of nutrients.
  • Dietary supplements or nutraceutical compositions that contain food supplements, vitamins, plant extracts and the like may lead to the treatment of, or at least reduce, age related damages, cardiovascular events, diabetes and the like. They may also reduce physical or mental fatigue, enhance activity and the like.
  • Dietary supplements or nutraceutical compositions may be in a form of a pill, capsule, powders, or liquids.
  • Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition
  • a dietary supplement or a nutraceutical composition comprising: water in an amount; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts; nutrient supplement and a preservative.
  • LBG Locust Bean Gum
  • Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition
  • a dietary supplement or a nutraceutical composition comprising: water in an amount of about 15% to about 75% by weight; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.
  • a dietary supplement or a nutraceutical composition comprising: water in an amount of about 15% to about 75% by weight; and xanthan gum, Locust Bean Gum (LBG) and gellan; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight; and a preservative.
  • the dietary supplement or a nutraceutical composition comprises: water in an amount of about 15% to about 75% by weight; xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w; and/or gellan gum in an amount of between about 0.1-0.5 %w/w; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.
  • the dietary supplement or a nutraceutical composition comprises: water in an amount of about 15% to about 75% by weight; xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w; and gellan gum in an amount of between about 0.1-0.5 %w/w; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.
  • the dietary supplement may further comprise a sweetener.
  • the dietary supplement or a nutraceutical composition comprises: water in an amount of at least 15%, 20%, 25%, 30%, 40%, 50%, 55%, 60%, 65%, 70% or 75% by weight; and one or more of xanthan gum in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; LBG in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; and/or gellan gum in an amount of at least about 0.1, 0.15, 0.20, 0.25, 0.3, 0.4 or 0.5% %w/w.
  • the dietary supplement or a nutraceutical composition comprises: water in an amount of at least 15%, 20%, 25%, 30%, 40%, 50%, 55%, 60%, 65%, 70% or 75% by weight; xanthan gum in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; LBG in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; and gellan gum in an amount of at least about 0.1, 0.15, 0.20 or 0.25 %w/w.
  • the amount of the xanthan gum is about 0.3 %w/w.
  • the amount of the LBG is about 0.3 %w/w.
  • the amount of the gellan gum is about 0.175 %w/w.
  • the dietary supplement or a nutraceutical composition further comprises apple sugar syrup.
  • the amount of the apple sugar syrup is between about 15%-90%.
  • the amount of the apple sugar syrup is between about 15-40 %w/w.
  • the amount of the apple sugar syrup is between about 20-30 %w/w.
  • the amount of the apple sugar syrup is between about 60-90 %w/w.
  • the amount of the apple sugar syrup is between about 65-78 %w/w.
  • the amount of the apple sugar syrup is between about 72 %w/w.
  • the sweetener when a sweetener is included, is stevia extract or sucralose. According to some embodiments, the stevia extract or sucralose is in an amount of between about 0.03%-0.4%.
  • dietary supplement or the nutraceutical composition may further include palatinose.
  • the palatinose is in an amount of between about 5-15% w/w.
  • the palatinose is in an amount of between about 7-12% w/w.
  • the palatinose is in an amount of between about 8-10% w/w.
  • the palatinose is in an amount of about 9% w/w.
  • the dietary supplement or a nutraceutical composition further comprises an acid.
  • the acid is citric acid, lactic acid, acetic acid, adipic acid, tartaric acid, phosphoric acid or malic acid or a combination thereof.
  • the amount of the preservative is between 0.01% to 0.20% w/w.
  • the preservative is potassium sorbate. In some embodiments, the amount of the potassium sorbate is about 0.05% w/w. In some embodiments, the amount of the potassium sorbate is between about 0.01% w/w to 0.1% w/w.
  • the formulation further comprises tri- sodium citrate.
  • the formulation further comprises tri- sodium citrate in an amount of between 0.05-1.00% w/w. In some embodiments, the formulation further comprises tri- sodium citrate in an amount of between 0.1-0.5% w/w. In some embodiments, the formulation further comprises tri-sodium citrate in an amount of between 0.2-0.4% w/w. In some embodiments of the invention the amount is about 0.3% w/w.
  • the plant extract is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba or paullinia cupana.
  • the plant extract is one or more of Hops (Humulus lupulus), Melissa officinalis (lemon balm), Chamomile Matricaria chamomilla (German chamomile), Panax quinquefolius, Withania somnifera Ashwagandha (American ginseng), Passion flower (Passiflora incarnate) or Astragalus membranacus
  • the plant extract is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba paullinia cupana or Astragalus membranacus.
  • acai Euterpe oleracea
  • green tea extract Echinacea pallida
  • sambucus nigra L. fruit sambucus nigra L. fruit
  • ilex paraguariensis Ginkgo biloba paullinia cupana or Astragalus membranacus.
  • the plant extract acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba paullinia cupana and Astragalus membranacus
  • the amount of the Astragalus membranacus is between 0.2-3%w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is between 0.4-2.5 %w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is between 0.5-2.0 %w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is about 0.8 %w/w
  • the nutrient supplement is one or more resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf), or methylcobalamin (vitamin B12).
  • the nutrient supplement comprises resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf) and methylcobalamin (vitamin B12).
  • the dietary supplement or the nutraceutical composition further comprising one or two vitamin mix formulations.
  • a flavor agent may be added such as, orange, apple, strawberry, or raspberry flavor agent.
  • a colorant may be added, such as, for example, tomato-o color and the like.
  • a gel comprising one or more of xanthan gum, LBG and/or gellan gum.
  • the method further comprises placing the gel comprising the one or more of xanthan gum, LBG, and/or gellan gum in packages.
  • Figure 1 presents the absorption of folic acid in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of folic acid.
  • Figure 2 presents the absorption of B12 in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of B 12.
  • Figure 3 presents the absorption of vitamin E in the blood at different time in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of vitamin E.
  • Figure 4 presents the absorption of vitamin A in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of vitamin A.
  • Figure 5 presents the absorption of magnesium in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of magnesium.
  • Figure 6 presents the absorption of calcium in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of calcium.
  • the invention is directed to a dietary supplement or a nutraceutical composition
  • a dietary supplement or a nutraceutical composition comprising water and one or more of xanthan gum, LBG and/or gellan gum, at least one nutrient supplement, and at least one preservative.
  • the dietary supplement or the nutraceutical composition further comprises at least one plant extract.
  • the dietary supplement or the nutraceutical composition further comprises at least one vitamin. It is noted that the plant extract and/or the vitamin may be a nutrient supplement.
  • the dietary supplement or the nutraceutical composition may further contain a sweetener.
  • Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition
  • a dietary supplement or a nutraceutical composition comprising: water in an amount; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts; nutrient supplement and a preservative.
  • LBG Locust Bean Gum
  • the invention is directed to a dietary supplement or a nutraceutical composition
  • a dietary supplement or a nutraceutical composition comprising water and xanthan gum, LBG and gellan gum, at least one nutrient supplement and at least one preservative.
  • the dietary supplement or the nutraceutical composition further comprises at least one plant extract.
  • the dietary supplement or the nutraceutical composition further comprises at least one vitamin. It is noted that the plant extract and/or the vitamin may be a nutrient supplement.
  • the dietary supplement or the nutraceutical composition of the invention has a high capacity for carrying any of the additives thereto and therefore, relatively small volumes of the gel of the invention may include relatively high concentrations of nutrients, sweeteners, preservatives, plant extracts, and/or vitamins.
  • the dietary supplement or the nutraceutical composition of the invention is formulated as a gel.
  • the invention provides a gel, which has a large capacity for vitamins and agents having a nutritional value.
  • the gel enables the packaging of the formulation in relatively small volume, but with a large capacity of vitamins and nutritional agents.
  • the packages include between 10-30 gram of a gel containing the nutritional supplements and such packages are sufficient for daily morning or night use.
  • a dietary supplement or a nutraceutical composition comprising: water in an amount of about 10% to about 25% by weight; one or more of xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and/or gellan gum in an amount of between about 0.1- 0.50 %w/w; and plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.
  • the amount of the xanthan gum is at least about 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w.
  • the amount of the LBG is at least about 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w.
  • the amount of the gellan gum is at least about 0.1, 0.125, 0.15, 0.175, 0.2, 0.225, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w.
  • the xanthan gum is Ziboxan® F200- xanthan gum food grade.
  • the gellan gum is Kelcogel® F gellan gum.
  • the LBG is seedgum® A- 175 LBG.
  • a dietary supplement or a nutraceutical composition comprising: water in an amount of about at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 2, 22, 23, 24, 25, 30% by weight; a gel comprising xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and gellan gum in an amount of between about 0.1-0.50 %w/w, plant extracts in an amount of at least about 0.2, 0.4, 0.6, 0.8, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5% or about 5% by weight; nutrient supplement in an amount of at least about 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5% or about 7% by weight and a preservative.
  • the dietary supplement or a nutraceutical composition of the invention further comprises apple sugar syrup.
  • the amount of the apple sugar syrup is between about 15%-90%. According to some embodiments, the amount of the apple sugar syrup is between about 20-30 %w/w. In some embodiments of the invention, the amount of the apple sugar syrup is at least about 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58 60, 65, 70, 71, 72, 73, 74, 75, 80, 82, 85 or about 90% by weight
  • the dietary supplement or a nutraceutical composition further comprises a xanthan gum.
  • the dietary supplement or a nutraceutical composition the xanthan gum is in an amount of between 0.1%-4% by weight. [0054] In some embodiments of the invention, the dietary supplement or a nutraceutical composition the xanthan gum is in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.7, 1, 1.3, 1.6, 1.8, 2, 2.3, 2.6, 2.9, 3.1, 3.3, 3.5, 3.7 or 4% by weight.
  • the sweetener in the dietary supplement or a nutraceutical composition is stevia extract or sucralose.
  • the stevia extract or sucralose is in an amount of between about 0.03%-0.4%.
  • the stevia extract or sucralose is in an amount of at least about 0.03, 0.05, 0.07, 0.09, 0.1, 0.2, 0.3 or 0.4%.
  • palatinose is added to the dietary supplement or the nutraceutical composition. According to some embodiments, the palatinose is in an amount of between about 5-15% w/w. According to some embodiments, the palatinose is in an amount of between about 7-12% w/w. According to some embodiments, the palatinose is in an amount of between about 8-10% w/w. According to some embodiments, the palatinose is in an amount of at least about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15% w/w.
  • the dietary supplement or a nutraceutical composition further comprises an acid.
  • the acid is selected from citric acid, lactic acid, acetic acid, adipic acid, tartaric acid, phosphoric acid or malic acid or a combination thereof.
  • the dietary supplement or a nutraceutical composition further comprises a vitamin and/or mineral mix.
  • the vitamin and/or mineral mix may further include food supplements or ingredients such as one or more of the ingredients in Table A:
  • the vitamin and/or mineral mix may further include food supplements or ingredients such as one or more of the ingredients in Table B:
  • the vitamin and/or mineral mix may further include one or more of the following ingredients specified in Table C:
  • the vitamin and/or mineral mix may further include one or more of the following ingredients specified in Table D:
  • both described mixes as in Table C and D are added to the dietary supplement or a nutraceutical composition
  • the dietary supplement or a nutraceutical composition comprises a preservative in an amount of between 0.01% to 0.50% by weight.
  • the preservative is potassium sorbate.
  • the amount of the potassium sorbate is 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1 or 0.15% by weight.
  • dietary supplement or a nutraceutical composition comprises a nutrient supplement.
  • the nutrient supplement is one or more resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf), or methylcobalamin (vitamin B12).
  • dietary supplement or a nutraceutical composition may also be termed here as "formulation”.
  • the dietary supplement or a nutraceutical composition comprises a plant extract, which is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba or paullinia cupana. In some embodiments these are the plant extracts included in the day formulation.
  • acai Euterpe oleracea
  • green tea extract Echinacea pallida
  • sambucus nigra L. fruit ilex paraguariensis
  • Ginkgo biloba or paullinia cupana are the plant extracts included in the day formulation.
  • the plant extracts and or active ingredients extracted from plants or synthetic materials (such as resveratrol or Coenzyme Q10) included in the dietary supplement or a nutraceutical composition are one or more of the following:
  • the plant extract and or active ingredients extracted from plants included in the dietary supplement or a nutraceutical composition are derived from one more of the following suggested source or part of the plant: Table 2
  • the dietary supplement or a nutraceutical composition comprises a plant extract that is one or more of Hops (Humulus lupulus), Melissa officinalis (lemon balm), Chamomile Matricaria chamomilla (German chamomile), Panax quinquefolius, Withania somnifera Ashwagandha (American ginseng), Passion flower (Passiflora incarnate).
  • Hops Human lupulus
  • Melissa officinalis lemon balm
  • Chamomile Matricaria chamomilla German chamomile
  • Panax quinquefolius Withania somnifera Ashwagandha (American ginseng), Passion flower (Passiflora incarnate).
  • these extracts are derived from one or more of the following sources/part of the plant.
  • the gel comprises the components as detailed in Table 4 below:
  • gel comprises the components as detailed in Table 5 below: Table 5
  • the gel comprises the components as detailed in Table 6 below:
  • the formulation further includes from the following nutritional supplements:
  • Methylcobalamin (vitamin B12) ment the formulation is as described in Table 8:
  • Vitamin C 0.8-1.8 0.8-1.8
  • the formulation is as described in Table 11 : Table 11
  • the formulation is as described in Table 12
  • vitamin mix MA 59 includes one or more of the following:
  • Vitamin A (RE) 0.5630 A Acetate 0.0862
  • Vitamin B 1 4.5000 Thiamine Mononitrate 0.7381
  • Vitamin B12 0.009 Vitamin B12
  • Vitamin D 0.0100 Cholecalciferol (D3) 0.0013
  • vitamin mix MA 71 includes one or more of the following:
  • the xanthan gum, LBG, gellan gum gel is placed in a package.
  • the gel is placed in a package.
  • the mixing of the xanthan gum, LBG and gellan gum together with and apple sugar syrup may be between about one minute to one hour. In some embodiments the mixing of the one or more of xanthan gum, LBG and/or gellan gum and apple sugar syrup may be between about 10 minutes to twenty minutes.
  • the xanthan gum, LBG and gellan gum and apple sugar syrup may be mixed until a homogenous mixture is reached. Water may be added to the mixture and the mixture may be agitated and heated to about 50, 55, 60, 65, 70, 75, 80, 85, 90 or 95°C until a homogenous solution is reached again. Plant extracts may then added together with the nutritional supplements and the composition may be heated to about 85.
  • composition may then allowed to be cooled to about 80, 75, 70, 65°C or less by, for example, exposing the pot in which the composition is formed to cold water.
  • the mixture i.e., the xanthan gum, LBG, and gellan gum gel of the invention, may then divided into packages and the packages may then sealed.
  • Capsule administration 14 healthy volunteers were recruited to the study. The capsule was administered as a single dose after 12 hours of fasting. The participants were monitored during 6 hours for the level of minerals and Multivitamin minerals in the blood, adverse events and vital signs.
  • Safety monitoring was performed for 6 hours and included - vital signs and adverse events monitoring.
  • Results are presented as mean ng/mL (plasma) vs. time.
  • the capsule/tablet formula included the following ingredients:
  • Vitamin mix MA59 and MA71 (described in Tables 13 and 14) were also added to the tested gel.
  • Figure 1 presents the absorption of folic acid in the blood at different time points.
  • the Average absorption of the folic acid from the gel was 58% i.e. 16% more than the average absorption of the folic acid from the tablets which was 42%.
  • Figure 2 presents the absorption of B12 in the blood at different time points. Average absorption of the vitamin B from the gel was 51% i.e. 2% more than the average absorption of the vitamin B from the tablets which was 49%.
  • Figure 3 presents the absorption of vitamin E in the blood at different time points. Average absorption of the vitamin E from the gel was 53% i.e. 6% more than the average absorption of the vitamin E from the tablets which was 47%.
  • Figure 4 presents the absorption of vitamin A in the blood at different time points. Average absorption of the vitamin A from the gel was 55% i.e. 10% more than the average absorption of the vitamin A from the tablets which was 45%.
  • Figure 5 presents the absorption of magnesium in the blood at different time points.
  • Average absorption of the magnesium from the gel was 55% i.e. 10% more than the average absorption of the magnesium from the tablets which was 45%.
  • Figure 6 presents the absorption of calcium in the blood at different time points. Average absorption of the calcium from the gel was 57% i.e. 14% more than the average absorption of the calcium from the tablets which was 43%.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un gel de carraghénane comprenant de l'eau, un ou plusieurs éléments parmi la gomme xanthane, la gomme de caroube et/ou la gomme gellane, un supplément nutritif, une vitamine et un conservateur. Du sirop de sucre de pomme est éventuellement ajouté.
PCT/IL2018/050216 2017-02-27 2018-02-27 Formulation de gel et son procédé de fabrication WO2018154585A1 (fr)

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US201762463748P 2017-02-27 2017-02-27
US62/463,748 2017-02-27

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458395B1 (en) * 1998-01-08 2002-10-01 Otsuka Foods Co., Ltd. Gelatinous food product and process for preparing the same
US20130259950A1 (en) * 2010-12-20 2013-10-03 Chun Gi Kim Method for preparing supplement using pettitoes or pig's head and zanthoxylum piperitum, and composition thereof
US20140134113A1 (en) * 2012-11-08 2014-05-15 Symrise Ag Pharmaceutical compositions
WO2016120228A1 (fr) * 2015-01-27 2016-08-04 Montero Gida Sanayi Ve Ticaret A.S. Composition édulcorante naturelle à base de luo han guo et de pomme

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458395B1 (en) * 1998-01-08 2002-10-01 Otsuka Foods Co., Ltd. Gelatinous food product and process for preparing the same
US20130259950A1 (en) * 2010-12-20 2013-10-03 Chun Gi Kim Method for preparing supplement using pettitoes or pig's head and zanthoxylum piperitum, and composition thereof
US20140134113A1 (en) * 2012-11-08 2014-05-15 Symrise Ag Pharmaceutical compositions
WO2016120228A1 (fr) * 2015-01-27 2016-08-04 Montero Gida Sanayi Ve Ticaret A.S. Composition édulcorante naturelle à base de luo han guo et de pomme

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