WO2018149754A1 - Composés de pyridine - Google Patents

Composés de pyridine Download PDF

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Publication number
WO2018149754A1
WO2018149754A1 PCT/EP2018/053332 EP2018053332W WO2018149754A1 WO 2018149754 A1 WO2018149754 A1 WO 2018149754A1 EP 2018053332 W EP2018053332 W EP 2018053332W WO 2018149754 A1 WO2018149754 A1 WO 2018149754A1
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alkyl
halogen
alkoxy
unsubstituted
substituted
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PCT/EP2018/053332
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English (en)
Inventor
Michael Seet
Ana Escribano Cuesta
Bernd Mueller
Antje Wolf
Nadine RIEDIGER
Marcus Fehr
Jan Klaas Lohmann
Erica CAMBEIS
Wassilios Grammenos
Violeta TERTERYAN-SEISER
Christian Harald Winter
Thomas Grote
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Basf Se
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Publication of WO2018149754A1 publication Critical patent/WO2018149754A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Definitions

  • the present invention relates to the use of pyridine compounds and the N-oxides and the salts thereof for combating phytopathogenic fungi, and to the novel compound and methods for combating phytopathogenic fungi and to seeds coated with at least one such compound.
  • the invention also relates to to compositions comprising at least one compound I .
  • the fungicidal activity of the known fungicidal compounds is unsatisfactory. Based on this, it was an object of the present invention to provide compounds having improved activity and/or a broader activity spectrum against phytopathogenic harmful fungi.
  • R 1 is in each case independently selected from H, halogen, OH, CN, NO2, SH, NH2, NH(Ci- C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, Ci-C 6 - alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the het- eroaryl contains one, two or three heteroatoms selected from N, O and S; wherein
  • R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with substituents R x1 independently selected from Ci-C 4 -alkyl, halogen, OH, CN, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 1 wherein the acyclic moieties of R 1 are unsubstituted or substituted with groups R 1a which independently of one another are selected from:
  • R 1a halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 - halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with substituents R 11a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 1 wherein the carbocyclic, heteroaryl and aryl moieties of R 1 are unsubstituted or substituted with groups R 1b which independently of one another are selected from: R 1 b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio;
  • heteroaryl is in each case independently selected from H, halogen, OH, CN, NO2, SH, NH2, NH(Ci- C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, Ci-C 6 - alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; wherein R x is as defined above;
  • R 2 wherein the acyclic moieties of R 2 are unsubstituted or substituted with groups R 2a which independently of one another are selected from:
  • R 2a halogen, OH, CN , Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci- C 4 -halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phe- noxy group is unsubstituted or substituted with substituents R 22a selected from the group consisting of halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, C1-C4- alkoxy and Ci-C 4 -halogenalkoxy;
  • R 2 wherein the carbocyclic, heteroaryl and aryl moieties of R 2 are unsubstituted or substituted with groups R 2b which independently of one another are selected from:
  • R 2b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cyclo- alkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio;
  • halogen is in each case independently selected from halogen, OH , CN, NO2, SH, NH2, NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 2 -C 4 -alkenyl), N(C 2 -C 4 -alkenyl) 2 , N H(C 2 -C 4 -al- kynyl), N(C 2 -C 4 -alkynyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , N(Ci-C 4 -alkyl)(C 2 - C 4 -alkenyl), N(Ci-C 4 -alkyl)(C 2 -C 4 -alkynyl), N(Ci-C 4 -alkyl)(C 3 -C 6 -cycloalkyl), N(C 2
  • R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6- alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl groups are unsubstituted or or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and C1-C4- halogenalkoxy;
  • R 3 wherein the acyclic moieties of R 3 are unsubstituted or substituted with groups R 3a which independently of one another are selected from:
  • R 3a halogen, OH, CN , Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with substituent R 31a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 3 wherein the carbocyclic, heteroaryl and aryl moieties of R 3 are unsubstituted or substituted with groups R 3b which independently of one another are selected from:
  • R 3b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C6-alkylthio;
  • R 4 is in each case independently selected from halogen, OH, CN, NO2, SH, NH2,
  • R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6- alkynyl, C2-C6-halogenalkynyl, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl groups are unsubstituted or or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and C1-C4- halogenalkoxy;
  • R 4 wherein the acyclic moieties of R 4 are unsubstituted or substituted with groups R 4a which independently of one another are selected from:
  • R 4a halogen, OH, CN, d-Ce-alkoxy, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with substituent R 41a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 4 wherein the carbocyclic, heteroaryl and aryl moieties of R 4 are unsubstituted or substituted with groups R 4b which independently of one another are selected from:
  • R 4b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C6-halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C6-alkylthio;
  • R 34 wherein the acyclic moieties of R 34 are unsubstituted or substituted with identical or different groups R 34a which independently of one another are selected from:
  • R 34a halogen, OH, CN, d-Ce-alkoxy, Cs-Ce-cycloalkyl, Cs-Ce-halogencycloal- kyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with R 341a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogen- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, CN, C3-C6-cycloalkyl, C3-C6- halogencycloalkyl, Ci-C4-alkylthio;
  • R 34 wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R 34 are unsubstituted or substituted with identical or different groups R 34b which independently of one another are selected from:
  • R 34b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, Cs-Ce- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, and Ci-C6-al- kylthio;
  • R 6 together with the carbon atoms to which they are bound form a phenyl or five- or six membered heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein the phenyl or heteroaryl is substituted with (R 56 ) 0 , wherein
  • o 0, 1 , 2 or 3;
  • R' and R" are independently selected from H , Ci-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R' and R" are independently unsubstituted or substituted with R'" which is independently selected from halogen, OH , CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-SO2- R x , Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogen
  • R 56 wherein the acyclic moieties of R 56 are not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R 56a which independently of one another are selected from:
  • R 56a halogen, OH, CN , Ci-C 6 -alkoxy, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, C 3 -C 6 - halogencycloalkyl, C3-C6-halogencycloalkenyl, Ci-C 4 -halogenalkoxy, Ci-C6-al- kylthio, five- or six-membered heteroaryl, phenyl and phenoxy; wherein the heteroaryl, phenyl and phenoxy group is unsubstituted or unsubstituted or substituted with R 561a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 56 wherein the carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R 56 are unsubstituted or substituted with identical or different groups R 56b which independently of one another are selected from:
  • R 56b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy, and Ci-C6-alkylthio; is O or S;
  • p 0, 1 or 2;
  • R 7a , R 8a halogen, OH , CN , N0 2 , SH , N H 2 , N H(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , N
  • n 0, 1 , 2;
  • R 7 and R 8 are independently not further substituted or carry 1 , 2, 3, 4, 5 or up to the maximum number of identical or different groups R 7b or R 8b , respectively, which independently of one another are selected from:
  • R 7b , R 8b halogen, OH , CN , N0 2 , SH , N H 2 , N H(Ci-C 4 -alkyl), N (Ci-C 4 -alkyl) 2 , N
  • R x and n is as defined above;
  • R 8 together with the carbon atom to which they are bound form a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle; wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, wherein the heteroatom N may carry one substituent selected from Ci-C4-alkyl, Ci-C4-halogenalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one, two or three substituents selected from CN, C1-C4- alkyl, halogen, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy; and wherein the heteroatom S may be in the form of its oxide SO or SO2, and wherein the carbocycle or heterocycle is unsubstituted or carries one, two, three or four substituents R 78
  • R 9 is in each case independently selected from H, OH, CN, SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci- C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, Ci-C 6 -alkoxy, C 3 -C 6 -cy- cloalkyl, saturated or partially unsaturated three-, four-, five-, six-, seven, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl and aryl;
  • R x is as defined above;
  • R 9 wherein the acyclic moieties of R 9 are unsubstituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R 9a which independently of one another are selected from:
  • R 9a halogen, OH, CN , d-Ce-alkoxy, Cs-Ce-cycloalkyl, Cs-Ce-halogencycloalkyl, Ci- C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or unsubstituted or substituted with R 9a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy, Ci-C4-halogenalkoxy, CN, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-al- kylthio;
  • R 9 wherein the carbocyclic, heterocyclic, heteroaryl and aryl moieties of R 9 are unsubstituted or substituted with identical or different groups R 9b which independently of one another are selected from:
  • R 9b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, Cs-Ce-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, and Ci-C6-alkylthio; and the N-oxides and the agriculturally acceptable salts of the compounds of formula I for combating phytopathogenic fungi.
  • the numbering of the ring members in the compounds of the present invention is as given in formula I above:
  • the numbering of the ring members and substituents in the compounds of the present invention is as given in formula I above.
  • intermediates IV can be accessed by starting from compounds of the formula VI and VII upon treatment with NaH in apolar or dipolar aprotic solvents at room temperature. Subsequent reduction e.g. with Fe in AcOH gives intermediates IV (see: Bioorganic & Medicinal Chemistr 15(17), 5912-5949; 2007).
  • the N-oxides may be prepared from the inventive compounds according to conventional oxida- tion methods, e. g. by treating compounds I with an organic peracid such as metachloroper- benzoic acid (cf. WO 03/64572 or J. Med. Chem. 38(1 1 ), 1892-903, 1995); or with inorganic oxidizing agents such as hydrogen peroxide (cf. J. Heterocyc. Chem. 18(7), 1305-8, 1981 ) or ox- one (cf. J. Am. Chem. Soc. 123(25), 5962-5973, 2001 ).
  • the oxidation may lead to pure mono- N-oxides or to a mixture of different N-oxides, which can be separated by conventional methods such as chromatography.
  • C n -C m indicates the number of carbon atoms possible in each case in the substituent or substituent moiety in question.
  • halogen refers to fluorine, chlorine, bromine and iodine.
  • Ci-C6-alkyl refers to a straight-chained or branched saturated hydrocarbon group having 1 to 6 carbon atoms, e.g. methyl, ethyl, propyl, 1 -methylethyl, butyl, 1 -methylpropyl, 2- methylpropyl, 1 ,1 -dimethylethyl, pentyl, 1 -methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dime- thylpropyl, 1 -ethylpropyl, 1 ,1 -dimethylpropyl, 1 ,2-dimethylpropyl, hexyl, 1 -methylpentyl, 2- methylpentyl, 3-methylpentyl, 4-methylpentyl, 1 ,1 -dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3-dimethyl- butyl, 2,2-dimethylbutyl
  • C2-C4-alkyl refers to a straight-chained or branched alkyl group having 2 to 4 carbon atoms, such as ethyl, propyl (n-propyl), 1 -methylethyl (iso-propoyl), butyl, 1 -methylpropyl (sec- butyl), 2-methylpropyl (iso-butyl), 1 ,1 -dimethylethyl (tert. -butyl).
  • Ci-C6-halogenalkyl refers to an alkyl group having 1 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as mentioned above.
  • Examples are "Ci-C2-halogenalkyl” groups such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlor- ofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1 -chloroethyl, 1 -bromoethyl, 1 -fluoro- ethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro- 2,2-difluoroethyl, 2,2-dichloro-2-fluoroe
  • Ci-C6-hydroxyalkyl refers to an alkyl group having 1 or 6 carbon atoms as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by OH groups.
  • Ci-C4-alkoxy-Ci-C4-alkyl refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radical is replaced by a Ci-C4-alkoxy group (as defined above).
  • Ci-C4-alkoxy-Ci-C4-alkyl refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radi- cal is replaced by a Ci-C6-alkoxy group (as defined above).
  • C2-C6-alkenyl refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and a double bond in any position.
  • Examples are “C2-C4-alkenyl” groups, such as ethenyl, 1 -propenyl, 2-propenyl (allyl), 1 -methylethenyl, 1 -butenyl, 2-butenyl, 3-butenyl, 1 -methyl-1 -propenyl, 2-methyl-1 -propenyl, 1 -methyl-2-propenyl, 2-methyl-2-propenyl.
  • C2-C6-alkynyl refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and containing at least one triple bond.
  • Examples are "C2-C4-al- kynyl” groups, such as ethynyl, prop-1 -ynyl, prop-2-ynyl (propargyl), but-1 -ynyl, but-2-ynyl, but- 3-ynyl, 1 -methyl-prop-2-ynyl.
  • Ci-C6-alkoxy refers to a straight-chain or branched alkyl group having 1 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkyl group.
  • Examples are “C1-C4- alkoxy” groups, such as methoxy, ethoxy, n-propoxy, 1 -methylethoxy, butoxy, 1 -methyhprop- oxy, 2-methylpropoxy or 1 ,1 -dimethylethoxy.
  • Ci-C6-halogenalkoxy refers to a Ci-C6-alkoxy radical as defined above, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as men- tioned above.
  • Ci-C4-halogenalkoxy groups, such as OCH2F, OCHF2, OCF3, OCH2CI, OCHCI2, OCCI3, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chlorothoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoro- ethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2- trichloroethoxy, OC2F5, 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy,
  • 2,3-difluoro-"propoxy 2 chloropropoxy, 3-chloropropoxy, 2,3-dichloropropoxy, 2-bromopropoxy, 3 bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, OCH2-C2F5, OCF2-C2F5, 1 -fluo- romethyl-2-fluoroethoxy, 1 -chloromethyl-2-chloroethoxy, 1 -bromomethyl-2-bromoethoxy, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or nonafluorobutoxy.
  • C2-C6-alkenyloxy refers to a straight-chain or branched alkenyl group having 2 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkenyl group. Examples are “C2-C4-alkenyloxy” groups.
  • C2-C6-alkynyloxy refers to a straight-chain or branched alkynyl group having 2 to 6 carbon atoms which is bonded via an oxygen, at any position in the alkynyl group. Examples are “C2-C4-alkynyloxy” groups.
  • C3-C6-cycloalkyl refers to monocyclic saturated hydrocarbon radicals having 3 to 6 carbon ring members, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl. Accordingly, a saturated three-, four-, five-, six-, seven-, eight-, nine or ten-membered carbocyclyl or carbo- cycle is a "C3-Cio-cycloalkyl".
  • C3-C6-cycloalkenyl refers to a monocyclic partially unsaturated 3-, 4- 5- or 6-mem- bered carbocycle having 3 to 6 carbon ring members and at least one double bond, such as cy- clopentenyl, cyclopentadienyl, cyclohexadienyl. Accordingly, a partially unsaturated three-, four- , five-, six-, seven-, eight-, nine or ten-membered carbocyclyl or carbocycle is a "C3-Cio-cycloal- kenyl".
  • C3-C8-cycloalkyl-Ci-C4-alkyl refers to alkyl having 1 to 4 carbon atoms (as defined above), whereAccording to one hydrogen atom of the alkyl radical is replaced by a cycloalkyl radical having 3 to 8 carbon atoms (as defined above).
  • Ci-C6-alkylthio refers to straight-chain or branched alkyl groups having 1 to 6 carbon atoms (as defined above) bonded via a sulfur atom. Accordingly, the term “Ci- C6-halogenalkylthio” as used herein refers to straight-chain or branched halogenalkyi group hav- ing 1 to 6 carbon atoms (as defined above) bonded through a sulfur atom, at any position in the halogenalkyi group.
  • the number of valence of carbon is 4, that of nitrogen is 3.
  • saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine or ten- membered heterocyclyl or heterocycle, wherein the heterocyclyl or heterocycle contains 1 , 2, 3 or 4 heteroatoms selected from N, O and S is to be understood as meaning both saturated and partially unsaturated heterocycles, wherein the ring member atoms of the heterocycle include besides carbon atoms 1 , 2, 3 or 4 heteroatoms independently selected from the group of O, N and S.
  • saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine or ten- membered heterocyclyl or heterocycle, wherein the heterocyclyl or heterocycle contains 1 , 2, 3 or 4 heteroatoms selected from N, O and S is to be understood as meaning both saturated and partially unsaturated heterocycles, wherein the ring member atoms of the heterocycle include besides carbon atoms 1 , 2, 3 or 4 heteroatoms independently selected from the group of O, N and
  • a 3- or 4-membered saturated heterocycle which contains 1 or 2 heteroatoms from the group consisting of O, N and S as ring members such as oxirane, aziridine, thiirane, oxetane, azet- idine, thiethane, [1 ,2]dioxetane, [1 ,2]dithietane, [1 ,2]diazetidine; and
  • a 5- or 6-membered saturated or partially unsaturated heterocycle which contains 1 , 2 or 3 heteroatoms from the group consisting of O, N and S as ring members such as 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isox- azolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazoli- dinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazoli- dinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imi
  • a 7-membered saturated or partially unsaturated heterocycle such as tetra- and hexahydroaze- pinyl, such as 2,3,4, 5-tetrahydro[1 H]azepin-1 -,-2-,-3-,-4-,-5-,-6- or-7-yl, 3,4,5,6-tetrahy- dro[2H]azepin-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,4,7-tetrahydro[1 H]azepin-1 -,-2-,-3-,-4-,-5-,-6- or-7-yl, 2,3,6,7-tetrahydro[1 H]azepin-1 -,-2-,-3-,-4-,-5-,-6- or-7-yl, hexahydroazepin-1 -,-2-,-3- or-4-yl, tetra- and hexahydrooxepinyl such as 2,3,4,5-tetrahydr
  • 5-or 6-membered heteroaryl or “5-or 6-membered heteroaromatic” refers to aromatic ring systems incuding besides carbon atoms, 1 , 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S, for example,
  • a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan- 2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-
  • a 6-membered heteroaryl such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyri- dazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • Agriculturally acceptable salts of the inventive compounds encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of said compounds.
  • Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, of the transition metals, preferably manga- nese, copper, zinc and iron, and also the ammonium ion which, if desired, may carry one to four Ci-C4-alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammo- nium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(Ci-C4-alkyl)sulfonium, and s
  • Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of Ci-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting such inventive compound with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.
  • the inventive compounds can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention.
  • the compounds of formula I and their N-oxides may have one or more centers of chirality, in which case they are present as pure enantiomers or pure di- astereomers or as enantiomer or diastereomer mixtures. Both, the pure enantiomers or dia- stereomers and their mixtures are subject matter of the present invention.
  • R 1 is in each case independently selected from hydrogen, halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C6-alkynyl, Ci-C6-alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl;
  • heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein
  • R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x1 independently selected from Ci-C 4 -alkyl, halogen, OH, CN, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 1 wherein the acyclic moieties of R 1 are unsubstituted or substituted with identical or different groups R 1a which independently of one another are selected from:
  • R 1a halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky, Ci-C 4 -halogen- alkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R 11a selected from the group consisting of halogen, OH, Ci- C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 1 wherein the carbocyclic, heteroaryl and aryl moieties of R 1 are unsubstituted or substituted with identical or different groups R 1b which independently of one another are selected from:
  • R 1b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • R 1 is H, halogen or Ci-C6-alkyl, in particular H, CH3, Et, F, CI, more specifically H, CH3, F or CI most preferred H, F or CI.
  • R 1 is hydrogen
  • R 1 is halogen, in particular Br, F or CI, more specifically F or CI.
  • R 1 is F
  • R 1 is CI
  • R 1 is Br.
  • R 1 is OH
  • R 1 is CN
  • R 1 is N0 2 .
  • R 1 is SH.
  • R 1 is NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 or NH-S0 2 -R x , wherein R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x1 independently selected from Ci-C 4 -al- kyl, halogen, OH, CN, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy, or Ci-C 4 -halogenalkoxy.
  • Ci-C4-alkyl such as NHCH3 and N(CH3)2.
  • R x is Ci-C4-alkyl, and phenyl that is substituted with one CH3, more specifically S02-R x is CH3 and tosyl group ("Ts").
  • R 1 is Ci-C6-alkyl, in particular Ci-C4-alkyl,
  • R 1 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CHF 2 , CH 2 F, CCI 3 , CHCI2, CH 2 CI, CF3CH2, CCI3CH2 or CF 2 CHF 2 .
  • R 1 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C 2 -C 4 -alkynyl or C 2 -C 4 -halogenalkynyl, such as C ⁇ CH, C ⁇ CCI, C ⁇ CF. CH 2 C ⁇ CH, CH 2 C ⁇ CCI, or CH 2 C ⁇ CF.
  • R 1 is Ci-C6-alkoxy, in particular Ci-C4-alkoxy, more specifically Ci-C2-alkoxy such as OCH3 or OCH2CH3.
  • R 1 is Ci-C6-halogenalkoxy, in particular Ci- C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCI3, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 1 is C3-C6-cycloalkyl, in particular cyclopro- pyl.
  • R 1 is C3-C6-cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or different groups R 1b as defined and preferably herein.
  • R 1 is C3-C6-halogencycloalkyl.
  • R 1 is fully or partially halogenated cyclopropyl.
  • R 1 is unsubstituted aryl or aryl that is substituted with one, two, three or four R 1b , as defined herein.
  • R 1 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 1b , as defined herein.
  • R 1 is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R 1 is 5- or 6-membered heteroaryl that is substituted with one, two or three R 1b , as defined herein.
  • R 1 is in each case independently selected from hydrogen, halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy and C3-C6-cycloalkyl; wherein the acyclic moieties of R 1 are not further substituted or carry one, two, three, four or five identical or different groups R 1a as defined below and wherein the carbocyclic, heteroaryl and aryl moieties of R 1 are not further substituted or carry one, two, three, four or five identical or different groups R 1b as defined below.
  • R 1 is independently selected from hydrogen, halogen, OH, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy, in particular independently selected from H, F, CI, Br, CN, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy.
  • R 1a are the possible substituents for the acyclic moieties of R 1 .
  • R 1a is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phe- noxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R 11a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halo- genalkyl, Ci-C2-alkoxy and Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • halogen such as F, CI and Br.
  • R 1a is independently selected from halogen, OH, CN, Ci-C2-alkoxy, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 1a is
  • R 1a is independently selected from halogen, such as F, CI, Br and I, more specifically F, CI and Br.
  • R 1a is independently selected from OH, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 1a is
  • R 1a is independently selected from aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 11a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • R 11a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-
  • R 1b are the possible substituents for the carbocyclic, heteroaryl and aryl moieties of R 1 .
  • R 1b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, Ci- C4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogen- alkoxy.
  • R 1b is independently selected from halogen, CN, C1-C2- alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 1b is independently selected from F, CI, Br, OH, CN, CH3, OCH3, CHF2, OCHF2, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -C - cyclopropyl, OCF 3 , and OCHF 2 .
  • R 1b is independently selected from halogen, Ci- C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 1b is independently selected from halogen, CN, OH, CH3, CHF2, OCHF2, OCF3, OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F 2 -cyclopropyl, 1 ,1 -C - cyclopropyl and halogenmethoxy, more specifically independently selected from F, CI, OH, CH3, OCH3, CHF 2 , OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F 2 -cyclopropyl, 1 ,1 -C - cyclopropyl, OCHF2 and OCF3.
  • R x in the substituent NH-S02-R X is in each case independently selected from Ci-C4-alkyl, C1-C4- halogenalkyl, unsubstituted aryl and aryl that is substituted with one, two, three, four or five substituents R x1 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.
  • R x is in each case independently selected from Ci-C4-alkyl, halogen, OH, CN and phenyl that is substituted with one, two or three R x1 independently selected from Ci-C2-alkyl, more specifically R x is in each case independently selected from Ci-C4-alkyl and phenyl that is substituted with one CH3, more specifically S02-R x is the tosyl group ("Ts").
  • R 1 Particularly preferred embodiments of R 1 according to the invention are in Table P1 below, wherein each line of lines P1 -1 to P1 -16 corresponds to one particular embodiment of the invention. Thereby, for every R 1 that is present in the inventive compounds, these specific
  • Ts stands for the tosylgroup S02-(p-CH3)phenyl.
  • R 2 is in each case independently selected from hydrogen, halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl;
  • heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein
  • R x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 2 wherein the acyclic moieties of R 2 are unsubstituted or substituted with identical or different groups R 2a which independently of one another are selected from:
  • R 2a halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky, Ci-C4-halogen- alkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 21a selected from the group consisting of halogen, OH, Ci-C4-alkyl, C1-C4- halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 2 wherein the carbocyclic, heteroaryl and aryl moieties of R 2 are unsubstituted or substituted with identical or different groups R 2b which independently of one another are selected from:
  • R 2b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalky, Ci-C4-halogenalkoxy and Ci-C6-alkylthio.
  • R 2 is H, halogen or Ci-C6-alkyl, in particular H, CH3, Et, F, CI, more specifically H, CH3, F or CI most preferred H, F or CI.
  • R 2 is halogen, in particular Br, F or CI, more specifically F or CI.
  • R 2 is F
  • R 2 is CI
  • R 2 is Br
  • R 2 is hydrogen
  • R 2 is OH
  • R 2 is CN
  • R 2 is N0 2 .
  • R 2 is SH.
  • R 2 is NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 or NH-S0 2 -R x , wherein R x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy, or Ci-C4-halogenalkoxy.
  • Ci-C4-alkyl such as NHCH3 and N(CH3) 2 .
  • R x is Ci-C4-alkyl, and phenyl that is substituted with one CH3, more specifically S0 2 -R x is CH3 and tosyl group ("Ts").
  • R 2 is Ci-C6-alkyl, in particular Ci-C4-alkyl, such as CH 3 or CH 2 CH 3 .
  • R 2 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CHF 2 , CH 2 F, CCI 3 , CHCI 2 , CH 2 CI, CF 3 CH 2 , CCI 3 CH 2 or CF 2 CHF 2 .
  • R 2 is C 2 -C6-alkynyl or C 2 -C6-halogenalkynyl, in particular C 2 -C 4 -alkynyl or C 2 -C 4 -halogenalkynyl, such as C ⁇ CH, C ⁇ CCI, C ⁇ CF. CH 2 C ⁇ CH, CH 2 C ⁇ CCI, or CH 2 C ⁇ CF.
  • R 2 is Ci-C6-alkoxy, in particular Ci-C4-alkoxy, more specifically Ci-C2-alkoxy such as OCH3 or OCH2CH3.
  • R 2 is Ci-C6-halogenalkoxy, in particular Ci- C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCIs, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 2 is C3-C6-cycloalkyl, in particular cyclopropyl.
  • R 2 is C3-C6-cycloalkyl, for example cyclopropyl, substituted with one, two, three or up to the maximum possible number of identical or different groups R 2b as defined and preferably herein.
  • R 2 is C3-C6-halogencycloalkyl.
  • R 2 is fully or partially halogenated cyclopropyl.
  • R 2 is unsubstituted aryl or aryl that is substituted with one, two, three or four R 2b , as defined herein.
  • R 2 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 2b , as defined herein.
  • R 2 is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R 2 is 5- or 6-membered heteroaryl that is substituted with one, two or three R 2b , as defined herein.
  • R 2 is in each case independently selected from hydrogen, halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy and C3-C6-cycloalkyl; wherein the acyclic moieties of R 2 are not further substituted or carry one, two, three, four or five identical or different groups R 2a as defined below and wherein the cycloalkyl moieties of R 2 are not further substituted or carry one, two, three, four or five identical or different groups R 2b as defined below.
  • R 2 is independently selected from hydrogen, halogen, OH, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy, in particular independently selected from H, F, CI, Br, CN, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, C1-C4- alkoxy and Ci-C 4 -halogenalkoxy.
  • R 2a are the possible substituents for the acyclic moieties of R 2 .
  • R 2a is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky, Ci-C 4 -halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 22a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and C1-C4- halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • halogen such as F, CI and Br.
  • R 2a is independently selected from halogen, OH, CN, C1-C2- alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky and Ci-C2-halogenalkoxy.
  • R 2a is independently selected from F, CI, OH, CN, Ci-C2-alkoxy, cyclopropyl, 1 -F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl and Ci-C2-halogenalkoxy.
  • R 2a is independently selected from halogen, such as F, CI, Br and I, more specifically F, CI and Br.
  • R 2a is independently selected from OH, C3- C6-cycloalkyl, C3-C6-halogencycloalky and Ci-C2-halogenalkoxy. Specifically, R 2a is
  • R 2a is independently selected from aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 22a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • R 22a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-
  • R 2b are the possible substituents for the carbocyclic, heteroaryl and aryl moieties of R 2 .
  • R 2b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, Ci- C4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalky and Ci-C4-halogen- alkoxy.
  • R 2b is independently selected from halogen, CN, C1-C2- alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 2b is independently selected from F, CI, Br, OH, CN, CH3, OCH3, CHF2, OCHF2, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl 1 ,1 -F2-cyclopropyl, 1 ,1 -C - cyclopropyl, OCF3, and OCHF2.
  • R 2b is independently selected from halogen, Ci- C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 2b is independently selected from halogen, OH, CH3, OCH3, CN, CHF2, OCHF2, OCF3, OCH3 cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl and halogenmethoxy, more specifically independently selected from F, CI, OH, CH3, OCH3, CHF2, OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -CI 2 -cyclopropyl, OCHF 2 and OCF 3 .
  • R 2 according to the invention are in Table P2 below, wherein each line of lines P2-1 to P2-16 corresponds to one particular embodiment of the invention. Thereby, for every R 2 that is present in the inventive compounds, these specific
  • Ts stands for the tosylgroup S02-(p-CH3)phenyl.
  • R 3 is in each case independently selected from halogen, OH , CN , NO2, SH , N H2, N H(Ci-C 4 - alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 2 -C 4 -alkenyl), N(C 2 -C 4 -alkenyl) 2 , N H(C 2 -C 4 -alkynyl), N(C 2 -C 4 - alkynyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , N(C2-C 4 -alkyl)(C2-C 4 -alkenyl), N(C 2 -C 4 - alkyl)(C 2 -C 4 -alkynyl), N(C2-C 4 -alkyl)(C 3 -C6-cycloalkyl), N(C2-C 4 -alken
  • heteroaryl contains one, two or three heteroatoms selected from N , O and S;
  • R x is as defined above;
  • R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6- alkynyl, C2-C6-halogenalkynyl, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl; phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl group is unsubstituted or substituted with substituents selected from the group consisting of halogen, CN , OH , C1-C6- alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy; wherein the acyclic moieties of R 3 are unsubstituted or substituted with groups R 3a which independently of one another are selected from:
  • R 3a halogen, OH , CN , Ci-C6-alkoxy, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with substituents R 31 a selected from the group consisting of halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 3b halogen, OH , CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cyclo- alkyl, C 3 -C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • R 3 is selected from the group consisting of halogen, CN , Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6- halogenalkynyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, and OR Y .
  • R 3 is halogen, in particular F, CI, Br or I, more specifically F, CI or Br, in particular F or CI.
  • R 3 is F.
  • R 3 is CI.
  • R 3 is Br.
  • R 3 is OH.
  • R 3 is CN.
  • R 3 is N0 2 .
  • R 3 is SH.
  • R 3 is NH 2 .
  • R 3 is , NH(C
  • R 3 is , N(Ci- NH(C 2 H 5 ) 2 .
  • R 3 is , NH(C
  • R 3 is , NH(C3-C6-cycloalkyl), in particular NH(C 3 H 7 ), NH(C 4 H 9 ).
  • R 3 is , N(C3-C6-cycloalkyl) 2 , in particular N(C 3 H 7 ) 2 , N(C 4 H 9 ) 2 .
  • R 3 is N(Ci-C4-alkyl)(C 2 -C4-alkynyl), in particular N(CH 3 )(C ⁇ CH), N(CH 3 )(CH 2 C ⁇ CH), N(C 2 H 5 )(C ⁇ CH), N(C 2 H 5 )(CH 2 C ⁇ CH).
  • R 3 is N(Ci-C4-alkyl)(C 3 -C6-cycloalkyl), in particular N(CH 3 )(C 3 H 7 ), N(CH 3 )(C 4 H 9 ), N(C 2 H 5 )(C 3 H 7 ), N(CH 3 )(C 4 H 9 ).
  • R 3 is N(C2-C 4 -alkynyl)(C3-C6-cycloalkyl), in particular N(C ⁇ CH)(C 3 H 7 ), N(CH 2 C ⁇ CH)(C 4 H 9 ), N(C ⁇ CH)(C 3 H 7 ), N(CH 2 C ⁇ CH)(C 4 H 9 ).
  • R 3 is NH-S0 2 -R x such as NH-S0 2 -CH 3 , NH-S0 2 -CH 2 -CH 3 , NH-S0 2 -CF 3 , NH-S0 2 -Ts.
  • R 3 is S(0)n-C 2 -C6-alkenyl such as
  • R 3 is Ci-C6-alkyl, in particular Ci-C4-alkyl, such as CH3. or C2H5, in particular CH3 or CH2CH3.
  • R 3 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CCI 3 , FCH 2 , CICH 2 , F 2 CH, CI 2 CH, CF3CH2, CCI3CH2 or CF 2 CHF 2 .
  • R 3 is OR Y , wherein R Y is Ci-C6-alkyl, Ci- C6-halogenalkyl, C 2 -C6-alkenyl, C 2 -C6-halogenalkenyl, C 2 -C6-alkynyl, C 2 -C6-halogenalkynyl, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl.
  • R 3 is OR Y , wherein R Y is Ci-C6-alkyl, in particular Ci-C 4 -alkyl, more specifically Ci-C 2 -alkoxy. R 3 is such as OCH3 or OCH2CH3.
  • R 3 is OR Y , wherein R Y is Ci-C6-halogen- alkyl, in particular Ci-C 4 -halogenalkyl, more specifically Ci-C2-halogenalkyl.
  • R 3 is such as OCF3, OCHF2, OCH2F, OCCI3, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 3 is OR Y , wherein R Y C2-C6-alkenyl, in particular C2-C 4 -alkenyl, more specifically Ci-C2-alkenyl.
  • R 3 is OR Y , wherein R Y C 2 -C6-halogen- alkenyl, in particular C2-C 4 -halogenalkenyl, more specifically Ci-C2-halogenalkenyl.
  • R 3 is OR Y , wherein R Y C2-C6-alkynyl, in particular C2-C6-alkynyl, in particular C2-C 4 -alkynyl, more specifically Ci-C2-alkynyl.
  • R 3 is such as OC ⁇ CH,
  • R 3 is OR Y , wherein R Y C2-C6-halogen- alkynyl, in particular C2-C6-halogenalkynyl, in particular C2-C 4 -halogenalkynyl, more specifically Ci-C 2 -halogenalkynyl.
  • R 3 is such as OC ⁇ CCI, OCH 2 C ⁇ CCI, or OCCI 2 C ⁇ CCI.
  • R 3 is is OR Y , wherein R Y C3-C6-cycloalkenyl, in particular cyclopropenyl.
  • R 3 is C3-C6-cycloalkyl, in particular cyclopro- pyl.
  • R 3 is C3-C6-halogencycloalkyl.
  • R 3b is fully or partially halogenated cyclopropyl, such as 1 -F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl .
  • R 3 is phenyl-Ci-C6-alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R 3b which independently of one another are selected from halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular F, CI, Br, CH 3 , OCH3, CF 3 and OCF 3 .
  • R 3 is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 3b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci- C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular CN, F, CI, Br, CH3, OCH3, CHF2, OCHF2, CF3 and OCF3.
  • R 3 is unsubstituted phenyl.
  • R 3 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 3 is a 5-membered heteroaryl such as pyr- rol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, is
  • R 3 is a 6-membered heteroaryl such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • R 3 is in each case independently selected from H, halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6- alkoxy, Ci-C6-halogenalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and C3-C6- halogencycloalkyl, wherein the acyclic moieties of R 3 are unsubstituted or substituted with iden- tical or different groups R 3a as defined and preferably defined herein, and wherein the carbocy-rod, phenyl and heteroaryl moieties of R 3 are unsubstituted or substituted with identical or different groups R 3b as defined and preferably defined herein.
  • R 3 is in each case independently selected from H, halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6- alkoxy, Ci-C6-halogenalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and C3-C6- halogencycloalkyl, wherein the acyclic moieties of R 3 are unsubstituted or substituted with identical or different groups R 3a as defined and preferably defined herein, and wherein the cycloalkyi moieties of R 3 are unsubstituted or substituted with identical or different groups R 3b as defined and preferably defined herein.
  • R 3a are the possible substituents for the acyclic moieties of R 3 .
  • R 3a is independently selected from halogen, OH, CN, C1-C6- alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substitu- ents R 31a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.
  • R 3a is independently selected from halogen, Ci-C6-alkoxy, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogenalkoxy.
  • R 3a is independently selected from F, CI, Br, I , Ci-C2-alkoxy, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, I -F2- cyclopropyl, 1 ,1 -Cl2-cyclopropyl and Ci-C2-halogenalkoxy.
  • R 3a is independently halogen, in particular selected from F, CI, Br and I , more specifically F, CI and Br.
  • R 3b are the possible substituents for the carbocyclic, heteroaryl and phenyl moieties of R 3 .
  • R 3b according to the invention is independently selected from halogen, OH, CN , Ci-C4-alkyl, C1-C4- alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and d-Ce-alkylthio.
  • R 3b is independently selected from halogen, CN, C1-C4- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkyl and Ci-C4-halogenalkoxy, in particular halogen, C1-C4- alkyl and Ci-C4-alkoxy.
  • R 3b is independently selected from F, CI, CN, CH3, OCH3 and halogenmethoxy.
  • R 3 Particularly preferred embodiments of R 3 according to the invention are in Table P3 below, wherein each line of lines P3-1 to P3-42 corresponds to one particular embodiment of the invention, wherein P3-1 to P3-42 are also in any combination with one another a preferred embodiment of the present invention.
  • the connection point to the carbon atom, to which R 3 is bound is marked with "#" in the drawings.
  • R 4 is in each case independently selected from halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 - alkyl), N(Ci-C 4 -alkyl) 2 , NH(C 2 -C 4 -alkenyl), N(C 2 -C 4 -alkenyl) 2 , NH(C 2 -C 4 -alkynyl), N(C 2 -C 4 - alkynyl) 2 , NH(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , N(C 2 -C 4 -alkyl)(C 2 -C 4 -alkenyl), N(C 2 -C 4 - alkyl)(C 2 -C 4 -alkynyl), N(C 2 -C 4 -cycloalkyl), N(C 2 -C 4 -alkyl)
  • heteroaryl contains one, two or three heteroatoms selected from N, O and S;
  • R x is as defined above;
  • R Y is as defined above;
  • R 4 wherein the acyclic moieties of R 4 are unsubstituted or substituted with groups R 4a which independently of one another are selected from:
  • R 4a halogen, OH, CN, d-Ce-alkoxy, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substituents R 41a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 4 wherein the carbocyclic, heteroaryl and aryl moieties of R 4 are unsubstituted or substituted with groups R 4b which independently of one another are selected from:
  • R 4b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • R 4 is selected from the group consisting of halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6- halogenalkynyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy and OR Y .
  • R 4 is secected from the group consisting of halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6- alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, Ci-C6-alkoxy, Ci-C6-halo- genalkoxy and OR Y .
  • R 4 is halogen, in particular F, CI, Br or 1, more specifically F, CI or Br, in particular • F or CI.
  • R 4 is F.
  • R 4 is CI.
  • R 4 is Br.
  • R 4 is OH.
  • R 4 is CN.
  • R 4 is N0 2 .
  • R 4 is SH.
  • R 4 is NH 2 .
  • R 4 is , NH(Ci-C 4 -alkyl), in particular NH(CH 3 ), NH(C 2 H 5 ).
  • R 4 is , N(Ci-C 4 -alkyl) 2 , in particular NH(CH 3 ) 2 , NH(C 2 H 5 ) 2 .
  • R 4 is , NH(C 2 -C 4 -alkynyl), in particular NH(C ⁇ CH), NH(CH 2 C ⁇ CH).
  • R 4 is , NH(C 3 -C6-cycloalkyl), in particular NH(C 3 H 7 ), NH(C 4 H 9 ).
  • R 4 is , N(C 3 -C6-cycloalkyl)2, in particular N(C 3 H 7 ) 2 , N(C 4 H 9 ) 2 .
  • R 4 is N(Ci-C4-alkyl)(C 2 -C4-alkynyl), in particular N(CH 3 )(C ⁇ CH), N(CH 3 )(CH 2 C ⁇ CH), N(C 2 H 5 )(C ⁇ CH), N(C 2 H 5 )(CH 2 C ⁇ CH).
  • R 4 is N(Ci-C4-alkyl)(C 3 -C6-cycloalkyl), in particular N(CH 3 )(C 3 H 7 ), N(CH 3 )(C 4 H 9 ), N(C 2 H 5 )(C 3 H 7 ), N(CH 3 )(C 4 H 9 ).
  • R 4 is N(C 2 -C4-alkynyl)(C 3 -C6-cycloalkyl), in particular N(C ⁇ CH)(C 3 H 7 ), N(CH 2 C ⁇ CH)(C 4 H 9 ), N(C ⁇ CH)(C 3 H 7 ), N(CH 2 C ⁇ CH)(C 4 H 9 ).
  • R 4 is NH-S0 2 -R x such as NH-S0 2 -CH 3 , NH-S0 2 -CH 2 -CH 3 , NH-S0 2 -CF 3 , NH-S0 2 -Ts.
  • R 4 is S(0)n-C 2 -C6-alkenyl such as
  • R 4 is Ci-C6-alkyl, in particular Ci-C4-alkyl, such as CH3. or C2H5, in particular CH3 or CH2CH3.
  • R 4 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CCI 3 , FCH 2 , CICH 2 , F 2 CH, CI 2 CH, CF3CH2, CCI3CH2 or CF 2 CHF 2 .
  • R 4 is C2-C6-alkynyl or C2-C6-halogen- alkynyl, in particular C2-C4-alkynyl or C2-C4-halogenalkynyl, such as C CH, CH2 C CH, C CCI, CH 2 C ⁇ CCI, or CCI 2 C ⁇ CCI.
  • R 4 is OR Y , wherein R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl.
  • R 4 is OR Y , wherein R Y is Ci-C6-alkyl, in particular Ci-C4-alkyl, more specifically Ci-C2-alkoxy. R 4 is such as OCH3 or OCH2CH3.
  • R 4 is OR Y , wherein R Y is Ci-C6-halogen- alkyl, in particular Ci-C4-halogenalkyl, more specifically Ci-C2-halogenalkyl.
  • R 4 is such as OCF3, OCHF2, OCH2F, OCCI3, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 4 is OR Y , wherein R Y C2-C6-alkenyl, in particular C2-C4-alkenyl, more specifically Ci-C2-alkenyl.
  • R 4 is OR Y , wherein R Y C2-C6-alkynyl, in particular C2-C6-alkynyl, in particular C2-C4-alkynyl, more specifically Ci-C2-alkynyl.
  • R 4 is such as OC ⁇ CH, OC ⁇ CCI, OCH 2 C ⁇ CCI, or OCCI 2 C ⁇ CCI
  • R 4 is OR Y , wherein R Y is C3-C6-cycloalkyl, in particular cyclopropyl.
  • R 4 is OR Y , wherein R Y is C3-C6-halogencyclo- alkyl.
  • R 1 is fully or partially halogenated cyclopropyl.
  • R 4 is is OR Y , wherein R Y C3-C6-cycloalkenyl, in particular cyclopropenyl.
  • R 4 is C3-C6-cycloalkyl, in particular cyclopropyl.
  • R 4 is C3-C6-halogencycloalkyl.
  • R 4b is fully or partially halogenated cyclopropyl, such as 1 -F-cyclopropyl, 1 -CI- cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl
  • R 4 is phenyl-Ci-C6-alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R 4b which independently of one another are selected from hal- ogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular F, CI, Br, CH 3 , OCH3, CF 3 and OCF 3 .
  • R 4 is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 4b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci- C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular CN, F, CI, Br, CH3, OCH3, CHF2, OCHF2, CF3 and OCF3.
  • R 4 is unsubstituted phenyl.
  • R 4 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 4 is a 5-membered heteroaryl such as pyr- rol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, is
  • R 3 is a 6-membered heteroaryl such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • R 4 is in each case independently selected from H, halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6- alkoxy, Ci-C6-halogenalkoxy,C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and C3-C6- halogencycloalkyl, wherein the acyclic moieties of R 4 are unsubstituted or substituted with identical or different groups R 4a as defined and preferably defined herein, and wherein the carbocy- die, phenyl and heteroaryl moieties of R 4 are unsubstituted or substituted with identical or different groups R 4b as defined and preferably defined herein.
  • R 4 is in each case independently selected from H, halogen, CN, Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6- alkoxy, Ci-C6-halogenalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and C3-C6- halogencycloalkyl, wherein the acyclic moieties of R 4 are unsubstituted or substituted with iden- tical or different groups R 4a as defined and preferably defined herein, and wherein the cycloalkyi moieties of R 4 are unsubstituted or substituted with identical or different groups R 4b as defined and preferably defined herein.
  • R 4a are the possible substituents for the acyclic moieties of R 3 .
  • R 4a is independently selected from halogen, OH, CN, C1-C6- alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenyl group is unsubstituted or substituted with substituents R 41a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.
  • R 4a is independently selected from halogen, Ci-C6-alkoxy, C3-C6- cycloalkyi, C3-C6-halogencycloalkyl and Ci-C4-halogenalkoxy.
  • R 4a is independently selected from F, CI, Br, I, Ci-C2-alkoxy, cyclopropyl, 1 -F-cyclopropyl, 1-CI-cyclopropyl, 1 , 1 -F2- cyclopropyl, 1 ,1 -Cl2-cyclopropyl and Ci-C2-halogenalkoxy.
  • R 4a is independently halogen, in particular selected from F, CI, Br and I, more specifically F, CI and Br.
  • R 4b are the possible substituents for the carbocyclic, heteroaryl and phenyl moieties of R 4 .
  • R 4b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, C1-C4- alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and d-Ce-alkylthio.
  • R 4b is independently selected from halogen, CN, C1-C4- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkyl and Ci-C4-halogenalkoxy, in particular halogen, C1-C4- alkyl and Ci-C4-alkoxy.
  • R 4b is independently selected from F, CI, CN, CH3, OCH3 and halogenmethoxy.
  • R 4 Particularly preferred embodiments of R 4 according to the invention are in Table P4 below, wherein each line of lines P4-1 to P4-42 corresponds to one particular embodiment of the inven- tion, wherein P4-1 to P4-42 are also in any combination with one another a preferred embodiment of the present invention.
  • the connection point to the carbon atom, to which R 4 is bound is marked with "#" in the drawings.
  • R N is the substituent of the heteroatom N that is contained in the heterocycle formed by R 3 and R 4 in some of the inventive compounds.
  • R N is selected from Ci-C4-alkyl, Ci-C4-halogenalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one, two or three substituents selected from Ci-C4-alkyl.
  • R N is in each case independently selected from Ci-C2-alkyl, Ci-C2-halogenalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl substituents.
  • R N is in each case independently selected from Ci-C2-alkyl, more particularly methyl. In one particular embodiment, R N is in each case independently selected from S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl.
  • R 3 and R 4 together with the carbon atoms to which they are bound form a saturated or partially unsaturated five-, six-or seven -membered carbo- and heterocycle that is unsubstituted or substituted.
  • R 3 and R 4 form a 3-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • it is substituted with R 34 .
  • R 3 and R 4 form a 4-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 5-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 6-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 7-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 3-membered saturated heterocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 4-membered saturated heterocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 5-membered saturated heterocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 it is substituted with R 34 .
  • R 3 and R 4 form a 6-membered saturated heterocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 7-membered saturated heterocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 5-membered saturated heteroaryl.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R 3 and R 4 form a 6-membered heteroaryl.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 34 .
  • R 34 is substituted with R 34 .
  • R x is as defined above;
  • R 34 wherein the acyclic moieties of R 34 are unsubstituted or substituted with identical or different groups R 34a which independently of one another are selected from:
  • R 34a halogen, OH, CN, Ci-C 6 -alkoxy, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogencycloalkyl, Ci-C 4 -halo- genalkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl group is unsubstituted or unsubstituted or substituted with R 341a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkoxy, CN, C3-C6-cycloalkyl, C 3 -C6-halogency- cloalkyl, Ci-C 4 -alkylthio;
  • R 34 wherein the carbocyclic, heterocyclic, heteroaryl and aryl of R 34 are unsubstituted or substituted with identical or different groups R 34b which independently of one another are selected from:
  • R 34b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • m is 1.
  • m is 2 or 3. According to one specific embodiment thereof, m is 2. According to still another embodiment of formula I, m is 3.
  • R 34 is halogen, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci- Ce-alkoxy or , Ci-C 6 -halogenalkoxy, in particular CH 3 , Et, CHF 2 , OCH 3 , OCHF 2 , OCF 3 , F, CI, more specifically H, CH 3 , F or CI most preferred F or CI.
  • R 34 is halogen, in particular Br, F or CI, more specifically F or CI.
  • R 34 is OH.
  • R 34 is CN.
  • R 34 is NH2, NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl)2 or NH-S02-R X , wherein R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x34 independently selected from C1-C4- alkyl.
  • R 34 is Ci-C6-alkyl, in particular Ci-C 4 -alkyl, such as CH 3 .
  • R 34 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CHF 2 , CH 2 F, CCI 3 , CHCI2 or CH 2 CI.
  • R 34 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C 2 -C 4 -alkynyl or C 2 -C 4 -halogenalkynyl, such as C ⁇ CH, CH 2 C ⁇ CH, C ⁇ C-CI, C ⁇ C- CH 3 , CH 2 C ⁇ CH, CH 2 C ⁇ CCI or CH 2 C ⁇ C-CH 3 .
  • R 34 is Ci-C6-alkoxy, in particular Ci-C 4 - alkoxy, more specifically Ci-C2-alkoxy such as OCH3 or OCH2CH3.
  • R 34 is Ci-C6-halogenalkoxy, in particular Ci- C 4 -halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCIs, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 34 is C3-C6-cycloalkyl, in particular cyclopro- pyl.
  • R 34 is C3-C6-cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or different groups R 34b as defined and preferably herein.
  • R 34 is C3-C6-halogencycloalkyl.
  • R 34 is fully or partially halogenated cyclopropyl.
  • R 34 is unsubstituted aryl or aryl that is substituted with one, two, three or four R 34b , as defined herein.
  • R 34 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 34b , as defined herein.
  • R 34 is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R 34 is 5- or 6-membered heteroaryl that is substituted with one, two or three R 34b , as defined herein.
  • R 34 is in each case independently selected from halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy and C3-C6-cycloalkyl; wherein the acyclic moieties of R 34 are not further substituted or carry one, two, three, four or five identical or different groups R 34a as defined below and wherein the carbocyclic, heterocyclic and heteroaryl moieties of R 34 are not further substituted or carry one, two, three, four or five identical or different groups R 34b as defined below.
  • R 34 is independently selected from halogen, OH, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy, in particular independently selected from F, CI, Br, CN, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy.
  • R 34a are the possible substituents for the acyclic moieties of R 34 .
  • R 34a is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phe- noxy, wherein the aryl and phenyl group is unsubstituted or unsubstituted or substituted with R 341a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy, Ci-C4-halogenalkoxy, CN, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-alkylthio.
  • R 34a is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phe- noxy, wherein the aryl and phenyl group is unsubstituted or unsubstituted or substituted with R 341a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halo- genalkyl, Ci-C2-alkoxy, Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • halogen such as F, CI and Br.
  • R 34a is independently selected from halogen, OH, CN, Ci-C2-alkoxy, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 34a is
  • R 34a is independently selected from halogen, such as F, CI, Br and I, more specifically F, CI and Br.
  • R 34a is independently selected from OH, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 34a is
  • R 34b are the possible substituents for the carbocyclic, heterocyclic and heteroaryl moieties of R 34 .
  • R 34b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, Ci- C4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogen- alkoxy.
  • R 34b is independently selected from halogen, CN, C1-C2- alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalky and Ci-C2-hal- ogenalkoxy.
  • R 34b is independently selected from F, CI, OH, CN, CH3, OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1-F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl and halogenmethoxy.
  • R 34b is independently selected from Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogen- alkoxy.
  • R 34b is independently selected from OH, CH3, OCH3, cyclopropyl, 1 -F- cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl and halogenmethoxy, more specifically independently selected from OH, CH3, OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 - Cl-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -Cl2-cyclopropyl cyclopropyl and OCHF2.
  • R 5 and R 6 together with the carbon atoms to whi Och they are bound together form a phenyl or five- or six-membered heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the heteroaryl carries zero, one, two, three or four substituents (R 56 ) 0 , wherein o is 0, 1 , 2 or 3; and
  • R 56 are independently selected from halogen, OH, CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl),
  • R 56 wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a which independently of one another are selected from:
  • R 56a halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, C3-C6-halogencyclo- alkyl, C3-C6-halogencycloalkenyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, five- or six-membered heteroaryl, phenyl and phenoxy, wherein the heteroaryl and phenyl group is unsubstituted or carries one, two, three, four or five substituents R 56a' selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 56 wherein the carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R 56 are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R 56b which independently of one another are selected from:
  • R 56b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C6-alkylthio.
  • R 5 and R 6 together with the carbon atoms to which they are bound form phenyl; wherein the phenyl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five- or six-membered heteroaryl; wherein the heteroaryl contains one or two heteroatoms selected from N, O and S, and wherein the heteroaryl carries zero, one or two substit- uents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five- or six-membered heteroaryl; wherein the heteroaryl contains one or two heteroatoms N, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five- or six-membered heteroaryl; wherein the heteroaryl contains one or two heteroatoms selected from S and O, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five- or six-membered heteroaryl; wherein the heteroaryl contains one heteroatom S, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five- or six-membered heteroaryl; wherein the heteroaryl contains one heteroatom O, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five-membered heteroaryl; wherein the heteroaryl contains one or two
  • heteroatoms selected from N, O and S, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five-membered heteroaryl; wherein the heteroaryl contains one or two
  • heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five-membered heteroaryl; wherein the heteroaryl contains one or two
  • heteroatoms selected from O and S and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five-membered heteroaryl; wherein the heteroaryl contains one heteroatom S, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a five-membered heteroaryl; wherein the heteroaryl contains one heteroatom O, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a six-membered heteroaryl; wherein the heteroaryl contains one or two heteroatoms selected from N, O and S, and wherein the heteroaryl carries zero, one or two substituents (R 56 )o, as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 5 and R 6 together with the carbon atoms to which they are bound form a six-membered heteroaryl; wherein the heteroaryl contains one or two heteroatoms N, and wherein the heteroaryl carries zero, one or two substituents (R 56 ) 0 , as defined and preferably defined herein, wherein o is 0, 1 or 2. According to one specific embodiment, o is 0. According to a further embodiment, o is 1 or 2. Particular embodiments thereof are listed in Table P56.
  • R 56 there can be zero, one, two or three R 56 present, namely for o is 0, 1 , 2 or 3.
  • o 0.
  • o is 1.
  • o is 2 or 3. According to one specific embodiment thereof, o is 2, according to a further specific embodiment, o is 3.
  • R 56 is halogen, in particular F, CI, Br or I, more specifically F, CI or Br, in particular F or CI.
  • R 56 is F.
  • R 56 is CI.
  • R 56 is Br.
  • R 56 is OH.
  • R 56 is CN.
  • R 56 is NO2.
  • R 56 is SH.
  • R 56 is NH2.
  • R 56 is , NH(Ci-C4-alkyl), N(Ci-C4-alkyl)2, ,
  • Ci-C 4 -alkyl is CH 3 , C 2 H 5 , n-propyl, i-pro- pyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 56 is NH-S02-R X such as NH-SO2-CH3, NH-SO2-CH2-CH3, NH-SO2-CF3 or NH-SO2-TS.
  • R 56 is Ci-C6-alkyl, in particular Ci-C4-alkyl, such as CH 3 , C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl., in particular CH 3 .
  • R 56 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CCI 3 , FCH 2 , CICH 2 , F 2 CH, CI 2 CH, CF 3 CH 2 , CCI 3 CH 2 or CF 2 CHF 2 .
  • R 56 is C 3 -C6-cycloalkyl, in particular cyclopro- pyl.
  • R 56 is C 3 -C6-halogencycloalkyl.
  • R 1 is fully or partially halogenated cyclopropyl.
  • R 56 is C 2 -C6-alkynyl, in particular C 2 -C4-alkynyl, more specifically C 2 -C 3 -alkynyl, such as C ⁇ CH.
  • R 56 is C 2 -C6-halogenalkynyl, in particular C 2 -C4-halogen- alkynyl, more specifically C 2 -C 3 -halogenalkynyl.
  • R 56 is Ci-C6-alkoxy, in particular Ci-C4-alkoxy, more specifically Ci-C 2 -alkoxy such as OCH 3 or OCH 2 CH 3 .
  • R 56 is Ci-C6-halogenalkoxy, in particular C1-C4- halogenalkoxy, more specifically Ci-C 2 -halogenalkoxy such as OCF 3 , OCHF 2 , OCH 2 F, OCCI 3 , OCHCI 2 , OCH 2 CI and OCF 2 CHF 2 , in particular OCF 3 , OCHF 2 and OCF 2 CHF 2 .
  • R 56 is C 2 -C6-alkynyloxy, in particular C 2 - C4-alkynyloxy, more specifically Ci-C 2 -alkynyloxy such as OC CH
  • R 56 is S(0) n -Ci-C6-alkyl, wherein alkyl is CH 3 , C 2 H 5 , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl and n is 1 , 2 or 3.
  • R 56 is S(0) n -Ci-C6-halogenalkyl, wherein halogenalkyl is CF 3 or CHF 2 and n is 1 , 2 or 3.
  • R 56 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 56b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • R 56 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 56b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • the heterocycle contains preferably one, two or three, more specifically one or two heteroatoms selected from N, O and S. More specifically, the hetereocycle contains one heteroatom selected from N, O and S. In particular, the heterocycle contains one or two, in particular one O.
  • R 56 is a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroatom.
  • the formed heterocycle is oxetane.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 56b . According to still another embodiment of formula I, it is substituted with R 56b .
  • R 56 is a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroatom.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 56b .
  • it is substituted with R 56 .
  • R 56 is a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 56b .
  • R 56b it is substituted with R 56b .
  • said 6-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O. According to one
  • the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R 56b . According to still another embodiment of formula I, it is substituted with R 56 .
  • R 56 is phenyl-Ci-C6-alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R 56b which independently of one another are selected from halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl and Ci-C2-halogenalkoxy, in particular CN, F, CI, Br, CH 3 , OCH 3 , CHF 2 , CF 3 OCHF 2 , and OCF 3 .
  • R 56 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 56b , as defined and preferably herein.
  • R 56 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 56b , as defined herein.
  • R 56 is unsubstituted phenyl.
  • R 56 is a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isoxa
  • R 56 is a 6-membered heteroaryl, such as pyr- idin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • R 56 is in each case independently selected from halogen, CN, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl, S(0) n -Ci-C6-alkyl, three-, four-, five- or six-membered saturated or partially unsaturated heterocycle, five- or six-membered heteroaryl and phenyl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a as defined and preferably defined herein, and wherein the heterocyclic, alicyclic, phenyl and heteroaryl moieties of
  • R 56 is in each case independently selected from halogen, CN, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, C3-C6- alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl, S(0) n -Ci-C6-alkyl, three-, four-, five- or six-membered saturated or partially unsaturated heterocycle, five- or six-membered heteroaryl and phe- nyl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a as defined and preferably defined herein, and wherein the heterocyclic, alipha-N-but
  • the acyclic and cyclic moieties of R 56 are not further substituted, according to another embodiment, the acyclic moieties of R 56 carry one, two, three or four identical or different groups R 56a as defined and preferably defined herein.
  • R 56 is in each case independently selected from halogen, CN, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and S(0) n -Ci-C6-alkyl, wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a as defined and preferably defined herein, and wherein the cycloalkyi moieties of R 56 are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R 56b as defined and preferably defined herein.
  • R 56 is in each case independently selected from halogen, CN, Ci-C6-alkyl, , Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy, Ci-C6-halo- genalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy, C3-C6-cycloalkyl and S(0) n -Ci-C6-alkyl, wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a as defined and preferably defined herein, and wherein the cycloalkyl moieties of R 56 are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R 56b as defined and preferably defined herein.
  • the acyclic and cyclic moieties of R 56 are not further substituted, according to another embodiment, the acyclic moieties of R 56 carry one, two, three or four identical or different groups R 56a as defined and preferably defined herein.
  • R 56 is in each case independently selected from halo- gen, Ci-C6-alkyl and Ci-C6-alkoxy, wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a defined and preferably defined herein.
  • R 56 is in each case independently selected from CN, halogen, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy, wherein the acyclic moieties of R 56 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 56a defined and preferably defined herein. Accordingto one specific embodiment, the acyclic and cyclic moieties of R 56 are not further substituted, according to another embodiment, the acyclic moieties of R 56 carry one, two, three or four identical or different groups R 56a as defined and preferably defined herein.
  • R 56a are the possible substituents for the acyclic moieties of R 56 .
  • R 56a is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, C3-C6- halogencycloalkyl, C3-C6-halogencycloalkenyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, five- or six- membered heteroaryl, phenyl and phenoxy, wherein the heteroaryl and phenyl group is unsubstituted or carries one, two, three, four or five substituents R 56a' selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and C1-C4- halogenalkoxy.
  • R 56a is independently selected from halogen, Ci-C6-alkoxy, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogenalkoxy. Specifically, R 56a is
  • R 56a is independently halogen, in particular selected from F, CI, Br and I, more specifically F, CI and Br.
  • R 56b are the possible substituents for the cycloalkyl, heterocyclyl, heteroaryl and phenyl moieties of R 56 .
  • R 56b according to the invention is independently selected from halogen, OH, CN, C1-C4- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4- halogenalkoxy and Ci-C6-alkylthio.
  • R 56b is independently selected from halogen, CN, C1-C4- alkyl, Ci-C4-alkoxy, Ci-C4-halogenalkyl and Ci-C4-halogenalkoxy, in particular halogen, C1-C4- alkyl and Ci-C4-alkoxy.
  • R 56b is independently selected from F, CI, CN, CH 3 , OCH 3 and halogenmethoxy.
  • R 5 and R 6 optionally substituted with (R 56 ) 0 , according to the invention are in Table P56 below, wherein each line of lines P56-1 to P56-82 corresponds to one particular embodiment of the invention, wherein P56-1 to P56-82 are also in any combination with one another a preferred embodiment of the present invention.
  • the positions of the heteroaryls marked with "#" represents the connection points (carbon atoms 5' and 6' in formula I) with the remaining skeleton of the compounds of formula I:
  • A is according to one embodiment O.
  • A is according to one further embodiment S.
  • B is according to one embodiment is -C(R 7 R 8 )-S-.
  • B is according to one further embodiment C(R 7 R 8 )-S(0)-.
  • B is according to one further embodiment C(R 7 R 8 )-S(0)2-.
  • B is according to one further embodiment -C(R 7 R 8 )-0-.
  • B is according to one further embodiment -C(R 7 R 8 )-NR 9 -.
  • R x is as defined above;
  • R 7 wherein the acyclic moieties of R 7 are independently not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 7a , which independently of one another are selected from:
  • R 7 wherein the carbocclic, heterocyclic, heteroaryl and aryl moieties of R 7 are independently unsubstituted or substituted with identical or different groups R 7b , which independently of one an- other are selected from:
  • R 7 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl, CN , C 2 -C6-alkenyl, C 2 -C6-halogenalkenyl, C 2 -C6-alkynyl, C 2 -C6-halogenalkynyl, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C6-alkylaryl, Ci-C6-alkylheteroaryl, phenyl, pyridine, py- rimidine, thiophene, imidazole, triazol, oxadiazol wherein the acyclic moieties of R 7 are unsubstituted or substituted with identical or different groups R 7a as defined below and wherein wherein the carbocycle, heterocycle, heteroaryl and aryl moieties are unsubstituted or substituted with substituents R
  • R 7 is H.
  • R 7 is F
  • R 7 is CI
  • R 7 is Br.
  • R 7 is OH.
  • R 7 is CN
  • R 7 is NO2.
  • R 7 is SH.
  • R 7 is Ci-C6-alkylthio, such as SCH3, SC2H5, Sn-propyl, Si-propyl, Sn-butyl, Si-butyl, Stert-butyl, Sn-pentyl, Si-pentyl, CH2SCH3 or
  • R 7 is Ci-C6-halogenalkylthio, such as SCF3, SCCI3, CH2SCF3 or CH2SCF3.
  • R 7 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R 7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 7 is selected from Ci-C6-halogenalkyl, phenyl-Chb, halogenphenyl- CH2, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R 7b as defined below.
  • R 7 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted withsubstituents R 7b as defined below. According to one embodiment thereof, the carbo- and heterocycle is unsubstituted.
  • R 7 is selected from substituted Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted withsubstituents R 7b as defined below.
  • R 7 is selected from Ci-C6-alkyl, Ci-C6-halogen- alkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloal- kyl, C3-C6-halogencycloalkyl, Ci-C6-alkylaryl, six-membered heteroaryl or aryl which is unsubstituted or substituted with halogen or Ci-C6-halogenalkyl, and wherein the acyclic moieties of R 7 are unsubstituted or substituted with identical or different groups R 7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R 7b as defined below.
  • R 7 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C6-alkylaryl, phenyl, pyridine, pyrimidine, thiophene, im- idazole, triazol, oxadiazol wherein the acyclic moieties of R 7 are unsubstituted or substituted with identical or different groups R 7a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R 7b as defined below.
  • R 7 is Ci-C6-alkyl such as CH3, C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 7 is Ci-C6-alkyl such as CH3, C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 7 is Ci-C6-alkyl such as CH3.
  • R 7 is Ci-C6-alkyl such as C2H5.
  • R 7 is Ci-C6-alkyl such as CH3, C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl which is substituted with at least one group R 7a , which independently of one another are selected from:
  • R 7 is CH3 is substituted with at least one group R 7a , which independently of one another are selected from:
  • R 7 is C2H5 is substituted with at least one group R 7a , which independently of one another are selected from:
  • R 7 is CH2CN.
  • R 7 is CH2OH.
  • R 7 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, more specifically Ci-C2-halogenalkyl, such as CF3, CC , FCH2, CICH2, F2CH, C CH, CF3CH2, CCI3CH2 or CF2CHF2.
  • R 7 is CH2F.
  • R 7 is CHF2.
  • R 7 is CF3.
  • R 7 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C2-C4-alkynyl or C2-C4-halogenalkynyl, such as C CH, C C-CI, CH2- C ⁇ CH, CH 2 -C ⁇ CCI or CH 2 - C ⁇ C-CH 3 .
  • R 7 is C2-C6-cycloalkynyl in particular C2-C4- cycloalkynyl, such as C C-cPr.
  • R 7 is Ci-C6-alkoxy, in particular C1-C4- alkoxy, more specifically Ci-C2-alkoxy such as OCH3, CH2CH3 or CH2OCH3.
  • R 7 is Ci-C6-alkyl-Ci-C6-alkoxy, in particular Ci-C4-alkyl-Ci-C4-alkoxy, more specifically Ci-C2-alkyl-Ci-C2-alkoxy, such as
  • R 7 is C2-C6-alkynyloxy, in particular C2- C4-alkynyloxy, more specifically Ci-C2-alkynyloxy such as OC CH, OChbC CH or ChbOC CH
  • R 7 is Ci-C6-halogenalkoxy, in particular Ci-C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCIs, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 7 is Ci-C6-alkyl-Ci-C6-halogenalkoxy, in particular Ci-C4-alkyl-Ci-C4-halogenalkoxy, more specifically Ci-C2-alkyl-Ci-C2-halogenalkoxy such as CH2OCF3, CH2OCHF2, CH2OCH2F, CH2OCCI3, CH2OCHCI2 or CH2OCH2CI, in particular CH2OCF3, CH 2 OCHF 2 , CH2OCCI3 or CH2OCHCI2.
  • alkyl is CH 3 , C 2 H 5 , n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 7 is Ci-C6-alkyl-NH(Ci-C4-alkyl) or Ci- C6-alkyl-N(Ci-C 4 -alkyl)2, wherein alkyl is CH3, C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 7 is Ci-C6-alkyl-S(0) n -Ci-C6-alkyl, wherein alkyl is CH3, C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl and n is 1 , 2 or 3.
  • R 7 is Ci-C6-alkyl-S(0) n -Ci-C6- halogenalkyl, wherein halogenalkyl is CF3 or CHF2 and n is 1 , 2 or 3.
  • R 7 is Ci-C6-alkyl-S(0) n -aryl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 7b which independently of one another are selected from halogen, Ci-C2-alkyl, C1-C2- alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6-alkyl, in particular F, CI, Br, CH3, OCH3, CF3, CHF2, OCHF2, OCF3. According to one embodiment, R 7 is unsubstituted phenyl.
  • R 7 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 7 is Ci-C6-alkyl-NH-S02-R x wherein R x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy, or Ci-C4-halogenalkoxy, such as CH2NHS02CF3 or
  • R 7 is selected from Ci-C6-alkyl which is substituted, a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R 7b as defined below.
  • the car- bocycle is unsubstituted.
  • R 7 is selected from Ci-C6-alkyl, especially CH2 which is substituted with a 3-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7b is substituted with R 7b .
  • R 7 is selected from Ci-C6-alkyl, especially CH2 which is substituted with a 4-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7b is substituted with R 7b .
  • R 7 is selected from Ci-C6-alkyl, especially with CH2 optionally substituted CH2 which is substituted with a 5-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7b is substituted with R 7b .
  • R 7 is selected from Ci-C6-alkyl, especially CH2 which is substituted with a 6-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7b is substituted with R 7b .
  • R 7 is Ci-C6-alkyl, especially CH2 substituted with a 4-membered saturated heterocyde which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members.
  • the heterocyde contains one O as heteroatom.
  • the formed heterocyde is oxetane.
  • the heterocyde is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7b .
  • R 7 is Ci-C6-alkyl, especially CH2 substituted with a 5-membered saturated heterocyde which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members.
  • the heterocyde contains one O as heteroatom.
  • the heterocyde is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7b .
  • R 7 is Ci-C6-alkyl, especially CH2 subsitited by a 6-membered saturated heterocyde which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7b it is substituted with R 7b .
  • said 6-membered saturated heterocycle contains 1 or 2, in particu- lar 1 , heteroatom(s) O.
  • the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7b .
  • R 7 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R 7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 7 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substituents R 7b as defined below. According to one embodiment thereof, the carbocycle or heterocycle is unsubstituted.
  • R 7 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substit- uents R 7b as defined below. According to one embodiment thereof, the carbocycle or heterocycle is unsubstituted.
  • R 7 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R 7b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 7 is a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b . According to still another embodiment of formula I, it is substituted with R 7b .
  • R 7 is a 3-membered saturated carbocycle, which is
  • R 7 is a 3-membered saturated carbocycle, which is substituted with halogen, more specifically by F, such as C3H3F2.
  • R 7 is a 3-membered saturated carbocycle, which is substituted with halogen. More specifically by CI, such as C3H3CI2.
  • R 7 is a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b . According to still another embodiment of formula I, it is substituted with R 7b .
  • R 7 is a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b . According to still another embodiment of formula I, it is substituted with R 7b .
  • R 7 is a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 7b . According to still another embodiment of formula I, it is substituted with R 7b .
  • R 7 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 7b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • R 7 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-mem- bered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 7b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • the heterocycle contains preferably one, two or three, more specifically one or two heteroatoms selected from N, O and S. More specifically, the hetereocycle contains one heteroatom selected from N, O and S. In particular, the heterocycle contains one or two, in particular one O.
  • R 7 is a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroatom.
  • the formed heterocycle is oxetane.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7b .
  • R 7 is a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroatom.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7 .
  • R 7 is a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • it is substituted with R 7b .
  • said 6-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O.
  • the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R 7b .
  • R 7 is phenyl-Ci-C6-alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R 7b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6- alkyl, in particular from CN, F, CI, Br, CH 3 , OCH 3 , CF 3 , CHF 2 , OCHF 2 , OCF 3 and S(0) 2 CH 3 .
  • R 7 is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 7b which independently of one another are selected from from CN, halogen, Ci-C2-al- kyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6-alkyl, in particular from CN, F, CI, Br, CH 3 , OCH 3 , CF 3 , CHF 2 , OCHF 2 , OCF 3 .
  • R 7 is unsubstituted phenyl.
  • R 7 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 7 is a 5-membered heteroaryl such as pyr- rol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, is
  • R 7 is a 6-membered heteroaryl, such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • R 7 Particularly preferred embodiments of R 7 according to the invention are in Table P7 below, wherein each line of lines P7-1 to P7-34 corresponds to one particular embodiment of the invention, wherein P7-1 to P7-34 are also in any combination with one another a preferred embodiment of the present invention.
  • the connection point to the carbon atom, to which R 7 is bound is marked with "#" in the drawings.
  • R x is as defined above;
  • R 8 wherein the acyclic moieties of R 8 are independently not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R 8a , which independently of one another are selected from:
  • alkyl 2 , NH-S0 2 -R x , Ci-C 6 -alkylthio, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy, Ci-C 4 -halo- genalkoxy, and S(0)n-Ci-C6-alkyl; and wherein R x , R' and R" are as defined above; n is 0, 1 , 2; and
  • R 8 wherein the carbo-, heterocyclic, heteroaryl and phenyl moieties of R 8 are independently unsubstituted or substituted with identical or different groups R 8b , which independently of one another are selected from:
  • R 8 is H.
  • R 8 is F
  • R 8 is CI
  • R 8 is Br.
  • R 8 is OH.
  • R 8 is CN
  • R 8 is NO2.
  • R 8 is SH.
  • R 8 is Ci-C6-alkylthio, such as SCH3, SC2H5, Sn-propyl, Si-propyl, Sn-butyl, Si-butyl, Stert-butyl, Sn-pentyl, Si-pentyl, CH2SCH3 or
  • R 8 is Ci-C6-halogenalkylthio, such as SCF3, SCCI3, CH2SCF3 or CH2SCF3.
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl or Ci-C6-alkyl which is substituted, Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R 8b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 8 is selected from Ci-C6-halogenalkyl, phenyl-Chb, halogenphenyl-Chb, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or is substituted with substituents R 8b as defined below.
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl or Ci-C6-alkyl which is substituted, Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six-membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted withsubstituents R 8b as defined below. According to one embodi- ment thereof, the carbo- and heterocycle is unsubstituted.
  • R 8 is selected from substituted Ci-C6-halogenalkyl, phenyl, halogenphenyl and three-, four-, five- or six- membered carbo- and heterocycle, wherein the carbo- and heterocycle is unsubstituted or substituted withsubstituents R 8b as defined below.
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halogen- alkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6-cycloal- kyl, C3-C6-halogencycloalkyl, Ci-C6-alkylaryl, six-membered heteroaryl or aryl which is unsubstituted or substituted with halogen or Ci-C6-halogenalkyl, and wherein the acyclic moieties of R 8 are unsubstituted or substituted with identical or different groups R 8a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R 8b as defined below.
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halo- genalkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, C3-C6- cycloalkyl, C3-C6-halogencycloalkyl, Ci-C6-alkylaryl, phenyl, pyridine, pyrimidine, thiophene, imidazole, triazol, oxadiazol wherein the acyclic moieties of R 8 are unsubstituted or substituted with identical or different groups R 8a as defined below and wherein wherein the carbocycle, heterocycle and heteroaryl and aryl moieties are unsubstituted or substituted with substituents R 8b as defined below.
  • R 8 is Ci-C6-alkyl such as CH3, C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 8 is Ci-C6-alkyl such as CH3.
  • R 8 is Ci-C6-alkyl such as C2H5.
  • R 8 is Ci-C6-alkyl such as CH3, C2H5, n-pro- pyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl which is substituted with at least one group R 8a , which independently of one another are selected from:
  • R 8 is C 2 H 5 is substituted with at least one group R 8a , which independently of one another are selected from:
  • R 8 is CH 2 CN.
  • R 8 is CH 2 OH.
  • R 8 is Ci-C6-halogenalkyl, in particular Ci-C 4 - halogenalkyl, more specifically Ci-C 2 -halogenalkyl, such as CF3, CCI3, FCH 2 , CICH 2 , F 2 CH, CI 2 CH, CF 3 CH 2 , CCI 3 CH 2 or CF 2 CHF 2 .
  • R 8 is CH 2 F.
  • R 8 is CHF 2 .
  • R 8 is CF3.
  • R 8 is C2-C6-cycloalkynyl in particular C2-C4- cycloalkynyl, such as C C-cPr.
  • R 8 is Ci-C6-alkoxy, in particular C1-C4- alkoxy, more specifically Ci-C2-alkoxy such as OCH3, CH2CH3 or CH2OCH3.
  • R 8 is Ci-C6-alkyl-Ci-C6-alkoxy, in particular Ci-C4-alkyl-Ci-C4-alkoxy, more specifically Ci-C2-alkyl-Ci-C2-alkoxy, such as
  • R 8 is C2-C6-alkynyloxy, in particular C2- C4-alkynyloxy, more specifically Ci-C2-alkynyloxy such as OC CH, OChbC CH or ChbOC CH
  • R 8 is Ci-C6-halogenalkoxy, in particular Ci-C4-halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCI3, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 8 is Ci-C6-alkyl-Ci-C6-halogenalkoxy, in particular Ci-C4-alkyl-Ci-C4-halogenalkoxy, more specifically Ci-C2-alkyl-Ci-C2-halogenalkoxy such as CH2OCF3, CH2OCHF2, CH2OCH2F, CH2OCCI3, CH2OCHCI2 or CH2OCH2CI, in particular CH2OCF3, CH 2 OCHF 2 , CH2OCCI3 or CH2OCHCI2.
  • R 8 is Ci-C6-alkyl-NH(Ci-C4-alkyl) orCi- C6-alkyl-N(Ci-C4-alkyl)2, wherein alkyl is CH3, C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl.
  • R 8 is Ci-C6-alkylthio, in particular C1-C4- alkoxy, more specifically Ci-C3-alkylthio such as CH2SCH3 or CH2SCH2CH3.
  • R 8 is Ci-C6-alkyl-S(0) n -Ci-C6-alkyl, wherein alkyl is CH3, C2H5, n-propyl, i-propyl, n-butyl, i-butyl, tert-butyl, n-pentyl or i-pentyl and n is 1 , 2 or 3.
  • R 8 is Ci-C6-alkyl-S(0) n -Ci-C6- halogenalkyl, wherein halogenalkyl is CF3 or CHF2 and n is 1 , 2 or 3.
  • R 8 is Ci-C6-alkyl-S(0) n -aryl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 8b which independently of one another are selected from halogen, Ci-C2-alkyl, C1-C2- alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6-alkyl, in particular F, CI, Br, CH3, OCH3, CF3, CHF2, OCHF2, OCF3.
  • R 8 is unsubstituted phenyl.
  • R 8 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 8 is Ci-C6-alkyl-NH-S02-R x wherein R x is Ci-C4-alkyl, Ci-C4-halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x2 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy, or Ci-C4-halogenalkoxy, such as ChbNHSC ⁇ CFs or
  • R 8 is selected from Ci-C6-alkyl which is sub- stituted, a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R 8b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 8 is selected from Ci-C6-alkyl, especially CH2 which is substi- tuted with a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is selected from Ci-C6-alkyl, especially CH2 which is substituted with a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is selected from Ci-C6-alkyl, especially CH2 which is substituted with a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b . According to one embodiment, R 8 is selected from Ci-C6-alkyl, especially Chb which is substituted with a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is Ci-C6-alkylheterocycle, especially CH2 substituted with a 4-membered saturated heterocyde which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members.
  • the heterocyde contains one O as heteroatom.
  • the formed heterocyde is oxetane.
  • the heterocyde is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkylheterocycle, especially CH2 substituted with a 5-membered saturated heterocyde which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members.
  • the heterocyde contains one O as heteroatom.
  • the heterocyde is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkylheterocycle, especially CH2 subsitited by a 6-membered saturated heterocyde which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heterocyde is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • said 6-membered saturated heterocyde contains 1 or 2, in particular 1 , heteroatom(s) O.
  • the respective 6-membered heterocyde is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered, wherein the carbocycle is unsubstituted or substituted with substituents R 8b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 8 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocyde, in particular three-, four-, five- or six-membered, wherein the heterocyde contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocyde are unsubstituted or substituted with substituents R 8b as defined below. According to one embodiment thereof, the carbocycle or heterocyde is unsubstituted.
  • R 8 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle or heterocyde, in particular three-, four-, five- or six-membered, wherein the heterocyde contains one, two, three or four heteroatoms selected from N, O and S, and wherein the carbocycle and heterocycle are unsubstituted or substituted with substit- uents R 8b as defined below. According to one embodiment thereof, the carbocycle or heterocycle is unsubstituted.
  • R 8 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-mem- bered, wherein the carbocycle is unsubstituted or substituted with substituents R 8b as defined below. According to one embodiment thereof, the carbocycle is unsubstituted.
  • R 8 is a 3-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is a 3-membered saturated carbocycle, which is
  • R 8 is a 3-membered saturated carbocycle, which is substituted with halogen, more specifically by F, such as C3H3F2.
  • R 8 is a 3-membered saturated carbocycle, which is substituted with halogen. More specifically by CI, such as C3H3CI2.
  • R 8 is a 4-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is a 5-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is a 6-membered saturated carbocycle. According to one embodiment thereof, the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is a partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 8b as defined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • R 8 is a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle, in particular three-, four-, five- or six-membered, wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, and wherein the heterocycle is unsubstituted or substituted with substituents R 8b as de- fined below. According to one embodiment thereof, the heterocycle is unsubstituted.
  • the heterocycle contains preferably one, two or three, more specifically one or two heteroatoms selected from N, O and S. More specifically, the hetereocycle contains one heteroatom selected from N, O and S. In particular, the heterocycle contains one or two, in particular one O.
  • R 8 is a 4-membered saturated heterocycle which contains 1 or 2 heteroatoms, in particular 1 heteroatom, from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroatom.
  • the formed heterocycle is oxetane.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is a 5-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S, as ring members.
  • the heterocycle contains one O as heteroa- torn.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is a 6-membered saturated heterocycle which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • said 6-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O.
  • the respective 6-membered heterocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is phenyl-Ci-C6-alkyl, such as phenyl- CH2, wherein the phenyl moiety in each case is unsubstituted or substituted with one, two or three identical or different groups R 8b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6- alkyl, in particular from CN, F, CI, Br, CH 3 , OCH 3 , CF 3 , CHF 2 , OCHF 2 , OCF 3 and S(0) 2 CH 3 .
  • R 8 is aryl, in particular phenyl, wherein the aryl or phenyl moiety in each case is unsubstituted or substituted with identical or different groups R 8b which independently of one another are selected from CN, halogen, Ci-C2-alkyl, Ci- C2-alkoxy, Ci-C2-halogenalkyl, Ci-C2-halogenalkoxy and S(0) n -Ci-C6-alkyl, in particular from CN, F, CI, Br, CH 3 , OCH 3 , CF 3 , CHF 2 , OCHF 2 , OCF 3 .
  • R 8 is unsubstituted phenyl.
  • R 8 is phenyl, that is substituted with one, two or three, in particular one, halogen, in particular selected from F, CI and Br, more specifically selected from F and CI.
  • R 8 is a 5-membered heteroaryl such as pyr- rol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol- 3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2- yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, is
  • R 8 is a 6-membered heteroaryl, such as pyri- din-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, py- rimidin-5-yl, pyrazin-2-yl and 1 ,3,5-triazin-2-yl and 1 ,2,4-triazin-3-yl.
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one N as ring member.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains two N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains three N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b it is substituted with R 8b .
  • said 5-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) O.
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one S as ring member.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one S and one N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b . According to a further specific embodiment of formula I, R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one S and two N as ring members. According to one embodiment thereof, the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b . According to still another embodiment of formula I, it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one oxygen and one N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8 .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 5-membered saturated heteroaryl which contains one oxygen and two N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 6-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 6-membered saturated heteroaryl which one N as ring member.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 6-membered saturated heteroaryl which two N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 10-membered saturated heteroaryl which contains 1 , 2 or 3, in particular 1 or 2, heteroatoms from the group consisting of N, O and S as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b it is substituted with R 8b .
  • said 10-membered saturated heterocycle contains 1 or 2, in particular 1 , heteroatom(s) N.
  • R 8 is Ci-C6-alkyl, especially Chb subsitited by a 10-membered saturated heteroaryl which one N as ring members.
  • the heteroaryl is unsubstituted, i.e. it does not carry any substituent R 8b .
  • it is substituted with R 8b .
  • R 8 is Chb substituted with a 5-membered heteroaryl such as pyrrol-1 -yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isoxazol-4-yl
  • R 8 is Chb substituted with a 6-membered heteroaryl, such as pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halogen- alkyl, CN, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6-halogenalkynyl, aryl, heteroaryl, three-, four-, five- or six-membered carbocycle and heterocycle, phenoxy, and C1-C6- alkyl substituted with CN, three-, four-, five- or six-membered carbocycle and heterocycle, aryl and heteroaryl; wherein the carbocycle and heterocycle is unsubstituted or carries one, two, three or four substituents R 8b as defined below.
  • R 8 is selected from Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-al- kynyl, C2-C6-halogenalkynyl, aryl, heteroaryl, cypropropyl and Ci-C6-alkyl substituted with aryl and heteroaryl; wherein the aryl and heteroaryl are unsubstituted or carries one, two, three or four substituents R 8b as defined below.
  • Particularly preferred embodiments of R 8 according to the invention are in Table P8 below, wherein each line of lines P8-1 to P8-182 corresponds to one particular embodiment of the invention, wherein P8-1 to P8-182 are also in any combination with one another a preferred embodiment of the present invention.
  • R 7 , R 8 together with the carbon atom to which they are bound form a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- or heterocycle; wherein the heterocycle contains one, two, three or four heteroatoms selected from N, O and S, wherein the heteroatom N may carry one substituent R N selected from Ci-C4-alkyl, Ci-C4-halogenalkyl and S02Ph, wherein Ph is un- substituted phenyl or phenyl that is substituted with one, two or three substituents selected from CN, Ci-C4-alkyl, halogen, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy; and wherein the heteroatom S may be in the form of its oxide SO or SO2, and wherein the carbocy- cle or heterocycle is unsubstituted or carries
  • R 7 and R 8 form a 3-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 7 and R 8 form a 4-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 7 and R 8 form a 5-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 7 and R 8 form a 6-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 7 and R 8 form a 7-membered saturated carbocycle.
  • the carbocycle is unsubstituted, i.e. it does not carry any substituent R 8b .
  • R 8b is substituted with R 8b .
  • R 7 and R 8 together with the carbon atom to which they are bound form a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered heterocycle that is unsubstituted or substituted.
  • the heterocycle formed by R 7 and R 8 is saturated.
  • this saturated heterocycle is unsubstituted.
  • the saturated heterocycle carries one, two, three or four substituents R 78 .
  • said heterocycle is four- or six-membered.
  • said heterocycle is four- or six-membered.
  • the heterocycle formed by R 7 and R 8 contains one, two or three, more specifically one or two, heteroatoms selected from NH and NR N , wherein R N is as defined and preferably defined below, more particularly selected from Ci-C2-alkyl, Ci-C2-halo- genalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl.
  • R N is as defined and preferably defined below, more particularly selected from Ci-C2-alkyl, Ci-C2-halo- genalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl.
  • it contains one or two heteroatoms NH, in particular one NH.
  • it contains one or two heteroatoms NR N , in particular one NR N , wherein R N in each case is as defined and preferably defined above.
  • the heterocycle formed by R 7 and R 8 contains one or two heteroatoms O. In one embodiment thereof, it contains one heteroatom O. In another embodiment, it contains two heteroatoms O.
  • the heterocycle formed by R 7 and R 8 is unsubstituted, i.e. it does not carry any substituent R 78 . According to a further embodiment, it carries one, two, three or four R 78 .
  • the heterocycle contains one O as heteroatom.
  • the formed heterocycle is oxetane.
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 78 .
  • it carries one, two, three or four R 78 .
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 78 .
  • it carries one, two, three or four R 78 .
  • the heterocycle is unsubstituted, i.e. it does not carry any substituent R 78 .
  • it carries one, two, three or four R 78 .
  • said 6-membered saturated heterocycle contains 1 or 2 heteroatoms selected from NH and NR N .
  • R 7 together with R 8 and with the carbon atom to which they are bound form a saturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbocycle, in particular three-, four-, five- or six-membered carbocycle, more specifically five- or six-membered carbocycle, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 7 and R 8 form a cyclopropyl, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 7 and R 8 form a cyclobutyl, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 7 and R 8 form a cyclopentyl, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 7 and R 8 form a cyclohexyl, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 7 and R 8 form a cycloheptyl, that is unsubstituted or carries one, two, three or four substituents R 78 as defined below.
  • R 78 are the possible substituents for the carbo- or heterocycle formed by R 7 and R 8 and are in- dependently selected from halogen, OH, CN, NO2, SH, NH 2 , d-Ce-alkyl, d-Ce-halogenalkyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, Ci-C6-alkylthio, Ci-C6-halogenalkylthio, Ci-C4-alkoxy-Ci-C4- alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituents R 78a selected from the group consisting of halogen, OH, C1-C4- alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy; and wherein in each case one or two CH2 groups of the carbo- or heterocycle may
  • R 78 is in each case independently selected from halogen, OH, CN, SH, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy and Ci-C6-al- kylthio. In one further preferred embodiment, R 78 is in each case independently selected from halogen, Ci-C6-alkyl and Ci-C6-halogenalkyl. In one further particular embodiment, R 78 is in each case independently selected from Ci-C6-alkyl, such as methyl and ethyl.
  • R N is the substituent of the heteroatom NR N that is contained in the heterocycle formed by R 7 and R 8 in some of the inventive compounds.
  • R N is selected from Ci-C4-alkyl, Ci-C4-halogenalk and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one, two or three substituents selected from Ci-C4-alkyl.
  • R N is in each case independently selected from Ci-C2-alkyl, Ci-C2-halogenalkyl and S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl substituents.
  • R N is in each case independently selected from Ci-C2-alkyl, more particularly methyl. In one particular embodiment, R N is in each case independently selected from S02Ph, wherein Ph is unsubstituted phenyl or phenyl that is substituted with one methyl.
  • R 7 , R 8 together with the carbon atom to which they are bound form a saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- or heterocycle; wherein the carbocycle or heterocycle is unsubstituted or carries one, two, three or four substituents R 78 independently selected from hal- ogen, OH , CN, N0 2 , SH, NH 2 , Ci-C 6 -alkyl, Ci-C 6 -halogenalkyl, Ci-C 6 -alkoxy, Ci-C 6 -halogen- alkoxy, Ci-C6-alkylthio, Ci-C6-halogenalkylthio, Ci-C4-alkoxy-Ci-C4-alkyl, phenyl and phenoxy, wherein the phenyl groups are unsubstituted or carry one, two, three, four or five substituent
  • R 7 , R 8 together with the carbon atom to which they are bound form a saturated or partially unsaturated four-, five-, six-membered carbo- or heterocycle; wherein the carbocycle or heterocycle is unsubstituted or carries one, two, three or four substituents R 78 independently selected from halogen, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy.
  • R x1 independently selected from Ci-C4-alkyl.
  • R x is in each case independently selected from Ci-C4-alkyl and phenyl that is substituted with one, two or three R x1 independently selected from Ci-C2-alkyl, more specifically R x is in each case independently selected from Ci-C4-alkyl and phenyl that is substituted with one CH3.
  • S0 2 -R is the tosyl group ("Ts").
  • R 7a is in each case independently selected from halogen, OH, CN, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, heteroaryl, phenyl and halogenphenyl, wherein the halogenphenyl is substituted with halogen selected from the group consisting of F, CI and Br.
  • R 7a is in each case independently selected from halogen, heteroaryl, phenyl and halogenphenyl, wherein the halogenphenyl is substituted with halogen selected from the group consisting of F, CI and Br, in particular selected from F and CI.
  • R 7a is in each case independently selected from halogen, CN, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy, Ci-C6-alkylthio, phenyl, and heteroaryl; wherein the heteroaryl and phenyl is substituted with halogen selected from the group consisting of F, CI and Br or by Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and C1-C4- halogenalkoxy.
  • R 7a is in each case independently selected from halogen heteroaryl and phenyl wherein the heteroaryl and phenyl is substituted with halogen selected from the group consisting of F, CI and Br, in particular selected from F and CI.
  • R 7b is in each case independently selected from halogen, OH, CN, SH, Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy and Ci-C6-al- kylthio. In one further preferred embodiment, R 7b is in each case independently selected from halogen, Ci-C6-alkoxy, Ci-C6-halogenalkoxy and Ci-C6-halogenalkyl. In one further particular embodiment, R 7b is in each case independently selected from Ci-C6-alkyl, such as methyl and ethyl. In one further particular embodiment, R 7b is in each case independently selected from halogen, such as F, CI and Br.
  • N(C( 0)Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , d-Ce-alkylthio, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 - alkoxy, Ci-C 4 -halogenalkoxy and S(0) n -Ci-C6-alkyl; wherein n is 0, 1 and 2;
  • R 8a is in each case independently selected from C1-C6- alkylthio, Ci-C 6 -halogenalkylthio, S(0) n -Ci-C 6 -alkyl, S(0) n -aryl, such as SCH 3 , S0 2 CH 3 , S0 2 Ph.
  • R 8a is in each case independently selected from NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , such as NH(CH 3 ), N(CH 3 ) 2 or NHS0 2 CH 3 ,
  • R 8a is in each case independently selected from C 3 -C6- cycloalkyl, C 3 -C6-halogencycloalkyl, such as cyclopropyl or fully or partially halogenated cyclo- propyl.
  • R 8a is in each case independently selected from C1-C6- alkoxy, Ci-C 6 -halogenalkoxy, such as OCF 3 , OCHF 2 , OCH 2 F, OCCI 3 , OCHCI 2 or OCH 2 CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 8a is in each case independently selected from aryl, wherein the aryl is substituted with halogen selected from the group consisting of F, CI, Br, CH 3 , CH F 2 , OCH 3 , OCH Fs, CN or S0 2 CH 3 .
  • R 8 is unsubstituted 5- or 6-membered heteroaryl.
  • R 8 is 5- or 6-membered heteroaryl substituted with halogen selected from the group consisting of F, CI, Br, CH 3 , CHF 2 , OCH 3 , OCHF 3 , CN or SO2CH3.
  • R 8a is in each case independently selected from halo- gen, OH, CN, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and heterocycle, wherein the heretocy- clocycle is a satureated and contains one N as a ring member.
  • R 8a is in each case independently selected from halogen, OH, CN, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, phenyl, aryl, and heteroaryl, wherein the aryl and heteroaryl are substituted from the group consisting of F, CI, Br, CH3, CHF2, OCH3, OCHF3, CN or SO2CH3.
  • R 8a is in each case independently selected from halogen, phenyl, halogenphenyl and heteroaryl, wherein the
  • halogenphenyl is substituted with halogen selected from the group consisting of F, CI and Br, in particular selected from F and CI.
  • R 8a is in each case independently selected from halogen, CN, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C6-alkoxy, Ci-C4-halogenalkoxy, Ci- C6-alkylthio, Ci-C6-halogenalkylthio, phenyl, wherein the phenyl is substituted with halogen se- lected from the group consisting of F, CI and Br or by Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy.
  • R 8a is in each case independently selected from halogen and phenyl wherein the phenyl is substituted with halogen selected from the group consisting of F, CI and Br, in particular selected from F and CI.
  • R 8b is in each case independently selected from halogen, OH, CN, SH , Ci-C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy, Ci-C6-halogenalkoxy, C1-C6- alkylthio and S(0) n -Ci-C6-alkyl.
  • R 8b is in each case independently selected from halogen, Ci-C6-alkoxy, Ci-C6-halogenalkyl, Ci-C6-halogen- alkoxy and S(0) n -Ci-C6-alkyl.
  • R 8b is in each case independently selected from Ci-C6-alkyl, such as methyl and ethyl. According to one further particular embodiment, R 8b is in each case independently selected from halogen, such as F, CI and Br. According to one further particular embodiment, R 8b is in each case independently selected from Ci-C6-alkoxy, such as OCH3. According to one further particular embodiment, R 8b is in each case independently selected from Ci-C4-halogenalkoxy, such as OCHF2 and OCF3. According to one further particular embodiment, R 8b is in each case independently selected from S(0) n -Ci-C 6 -alkyl. such as SO2CH3.
  • R 9 is in each case independently selected from H OH, CN, NO2, SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, Ci- C6-alkoxy, C3-C6-cycloalkyl, five- or six-membered heteroaryl and aryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S; and wherein
  • R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x9 independently selected from Ci-C 4 -alkyl, halogen, OH, CN, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 9 wherein the acyclic moieties of R 9 are unsubstituted or substituted with identical or different groups R 9a which independently of one another are selected from:
  • R 9a halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalky, Ci-C 4 -halogen- alkoxy, Ci-C6-alkylthio, aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R 9 a selected from the group consisting of halogen, OH, Ci- C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 9 wherein the carbocyclic, heteroaryl and aryl moieties of R 9 are unsubstituted or substituted with identical or different groups R 9b which independently of one another are selected from:
  • R 9 halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • R 9 is H or Ci-C6-alkyl, in particular H or CH3.
  • R 9 is OH.
  • R 9 is CN
  • R 9 is SH.
  • R 9 is NH2, NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl)2 or NH-S02-R X , wherein R x is Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, unsubstituted aryl or aryl that is substituted with one, two, three, four or five substituents R x9 independently selected from Ci-C 4 -al- kyl, halogen, OH, CN, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy, or Ci-C 4 -halogenalkoxy.
  • Ci-C 4 -alkyl such as NHCH3 and N(CH3)2.
  • R x is Ci-C 4 -alkyl, and phenyl that is substituted with one CH3, more specifically S02-R x is CH3 and tosyl group ("Ts").
  • R 9 is Ci-C6-alkyl, in particular Ci-C 4 -alkyl, such as CH 3 or CH 2 CH 3 .
  • R 9 is Ci-C6-halogenalkyl, in particular C1-C4- halogenalkyl, such as CF 3 , CHF 2 , CH 2 F, CCI 3 , CHC , CH 2 CI, CF3CH2, CCI3CH2 or CF 2 CHF 2 .
  • R 9 is C2-C6-alkynyl or C2-C6-halogenalkynyl, in particular C 2 -C 4 -alkynyl or C 2 -C 4 -halogenalkynyl, such as C ⁇ CH, C ⁇ CCI, C ⁇ CF. CH 2 C ⁇ CH, CH 2 C ⁇ CCI, or CH 2 C ⁇ CF.
  • R 9 is Ci-C6-alkoxy, in particular C1-C4- alkoxy, more specifically Ci-C2-alkoxy such as OCH3 or OCH2CH3.
  • R 9 is Ci-C6-halogenalkoxy, in particular Ci- C 4 -halogenalkoxy, more specifically Ci-C2-halogenalkoxy such as OCF3, OCHF2, OCH2F, OCCI3, OCHC or OCH2CI, in particular OCF 3 , OCHF 2 , OCCI 3 or OCHCI 2 .
  • R 9 is C3-C6-cycloalkyl, in particular cyclopro- pyl.
  • R 9 is C3-C6-cycloalkyl, for example cyclopro- pyl, substituted with one, two, three or up to the maximum possible number of identical or different groups R 9 b as defined and preferably herein.
  • R 9 is C3-C6-halogencycloalkyl.
  • R 9 is fully or partially halogenated cyclopropyl.
  • R 9 is unsubstituted aryl or aryl that is substituted with one, two, three or four R 9b , as defined herein.
  • R 9 is unsubstituted phenyl or phenyl that is substituted with one, two, three or four R 9b , as defined herein.
  • R 9 is unsubstituted 5- or 6-membered heteroaryl. According to still a further embodiment, R 9 is 5- or 6-membered heteroaryl that is substituted with one, two or three R 9b , as defined herein.
  • R 9 is in each case independently selected from H, OH, CN, SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-S0 2 -R x , Ci-C 6 -alkyl, C 2 -C 6 - alkenyl, C2-C6-alkynyl, Ci-C6-alkoxy and C3-C6-cycloalkyl; wherein the acyclic moieties of R 9 are not further substituted or carry one, two, three, four or five identical or different groups R 9a as defined below and wherein the carbocyclic, heteroaryl and aryl moieties of R 9 are not further substituted or carry one, two, three, four or five identical or different groups R 9b as defined below.
  • R 9 is independently selected from H OH, Ci- C6-alkyl, Ci-C6-halogenalkyl, Ci-C6-alkoxy and Ci-C6-halogenalkoxy, in particular independently selected from H, CN, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogen- alkoxy.
  • R 9a are the possible substituents for the acyclic moieties of R 9 .
  • R 9a according to the invention is independently selected from halogen, OH, CN, Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy, Ci-C6-alkylthio, aryl and phe- noxy, wherein the aryl and phenoxy group is unsubstituted or unsubstituted or substituted with R 9 a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, C1-C4- alkoxy and Ci-C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halo- genalkyl, Ci-C2-alkoxy and Ci-C2-halogenalkoxy, more specifically selected from
  • R 9a is independently selected from halogen, OH, CN, Ci-C2-alkoxy, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 9a is
  • R 9a is independently selected from halogen, such as F, CI, Br and I, more specifically F, CI and Br.
  • R 9a is independently selected from OH, C3- C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C2-halogenalkoxy. Specifically, R 9a is
  • R 9a is independently selected from aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 9a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular selected from halogen, Ci-C2-alkyl, Ci-C2-halogenalkyl, C1-C2- alkoxy and Ci-C2-halogenalkoxy, more specifically selected from halogen, such as F, CI and Br.
  • R 9a is independently selected from aryl and phenoxy, wherein the aryl and phenoxy group is unsubstituted or substituted with R 9a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci- C4-halogenalkoxy, in particular
  • R 9b are the possible substituents for the carbocyclic, heteroaryl and aryl moieties of R 9 .
  • R 9b according to the invention is independently selected from halogen, OH, CN, Ci-C4-alkyl, Ci- C4-alkoxy, Ci-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and Ci-C4-halogen- alkoxy.
  • R 9b is independently selected from halogen, CN, C1-C2- alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 9 b is independently selected from F, CI, Br, OH, CN, CH3, OCH3, CHF2, OCHF2, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F2-cyclopropyl, 1 ,1 -C - cyclopropyl, OCF 3 , and OCHF 2 .
  • R 9b is independently selected from halogen, Ci- C2-alkyl, Ci-C2-alkoxy, Ci-C2-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C2- halogenalkoxy.
  • R 9 b is independently selected from halogen, CN, OH, CH3, CHF2, OCHF2, OCF3, OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F 2 -cyclopropyl, 1 ,1 -C - cyclopropyl and halogenmethoxy, more specifically independently selected from F, CI, OH, CH3, OCH3, CHF 2 , OCH3, cyclopropyl, 1 -F-cyclopropyl, 1 -CI-cyclopropyl, 1 ,1 -F 2 -cyclopropyl, 1 ,1 -C - cyclopropyl, OCHF2 and OCF3.
  • R x in the substituent NH-S02-R X is in each case independently selected from Ci-C4-alkyl, C1-C4- halogenalkyl, unsubstituted aryl and aryl that is substituted with one, two, three, four or five substituents R x9 independently selected from Ci-C4-alkyl, halogen, OH, CN, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy.
  • R x is in each case independently selected from Ci-C4-alkyl, halogen, OH, CN and phenyl that is substituted with one, two or three R x9 independently selected from Ci-C2-alkyl, more specifically R x is in each case independently selected from Ci-C4-alkyl and phenyl that is substituted with one CH3, more specifically S02-R : is the tosyl group ("Ts").
  • R 9 Particularly preferred embodiments of R 9 according to the invention are in Table P9 below, wherein each line of lines P9-1 to P9-12 corresponds to one particular embodiment of the invention. Thereby, for every R 9 that is present in the inventive compounds, these specific
  • Ts stands for the tosylgroup S02-(p-CH3)phenyl.
  • the intention relates further to novel compouds of the formula I with the R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, B, R 7 , R 8 and R 9 as defined above, with the proviso that
  • R 3 is OR Y , R Y is not C 2 -C 6 -alkyl; or
  • R 56 is not NH2 und NH-SO2-R x .
  • novel compounds of the formula I having R 1 , R 2 , R 4 , R 5 , R 6 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 3 is in each case independently selected from halogen, OH, CN, NO2, SH, NH2, NH(Ci-C 4 - alkyl), N(Ci-C 4 -alkyl) 2 , NH(C 2 -C 4 -alkenyl), N(C 2 -C 4 -alkenyl) 2 , NH(C 2 -C 4 -alkynyl), N(C 2 -C 4 - alkynyl) 2 , NH(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , N(Ci-C 4 -alkyl)(C 2 -C 4 -alkenyl), N(Ci- C 4 -alkyl)(C 2 -C 4 -alkynyl), N(Ci-C 4 -alkyl)(C 3 -C 6 -cycloalkyl), N(C2-C 4 -al
  • R Y is Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogenalkenyl, C2-C6-alkynyl, C2-C6- halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, phenyl and phenyl-Ci- C6-alkyl; wherein the phenyl groups are unsubstituted or or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH , Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 3 wherein the acyclic moieties of R 3 are unsubstituted or substituted with groups R 3a which independently of one another are selected from:
  • R 3a halogen, OH, CN , Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with substituent R 31a selected from the group consisting of halogen, OH , Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 3 wherein the carbocyclic, heteroaryl and aryl moieties of R 3 are unsubstituted or substituted with groups R 3b which independently of one another are selected from:
  • R 3b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C6-alkylthio.
  • novel compounds of the formula I having R 1 , R 2 , R 4 , R 5 , R 6 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 3 is in each case independently selected from halogen, OH , CN, NO2, SH, NH2, NH(Ci-C4- alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 2 -C 4 -alkenyl), N(C 2 -C 4 -alkenyl) 2 , N H(C 2 -C 4 -alkynyl), N(C 2 -C 4 - alkynyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , N(Ci-C 4 -alkyl)(C2-C 4 -alkenyl), N(Ci- C 4 -alkyl)(C2-C 4 -alkynyl), N(Ci-C 4 -alkyl)(C 3 -C 6 -cycloalkyl), N(C2-C 4 -alkenyl)
  • R 3 wherein the acyclic moieties of R 3 are unsubstituted or substituted with groups R 3a which independently of one another are selected from:
  • R 3a halogen, OH, CN , Ci-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with substituent R 31a selected from the group consisting of halogen, OH , Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 3 wherein the carbocyclic, heteroaryl and aryl moieties of R 3 are unsubstituted or substituted with groups R 3b which independently of one another are selected from: R 3b halogen, OH , CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • R 3b halogen, OH , CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • novel compounds of the formula I having R 1 , R2, R 3 , R 5 , R 6 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 4 is in each case independently selected from halogen, OH , CN , NO2, SH , N H 2 , N H(Ci-C 4 - alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 2 -C 4 -alkenyl), N (C 2 -C 4 -alkenyl) 2 , N H(C 2 -C 4 -alkynyl), N (C 2 -C 4 - alkynyl) 2 , N H(C 3 -C 6 -cycloalkyl), N (C 3 -C 6 -cycloalkyl) 2 , N(Ci-C 4 -alkyl)(C 2 -C 4 -alkenyl), N (Ci- C 4 -alkyl)(C 2 -C 4 -alkynyl), N (Ci-C 4 -alkyl)(C 3 -C 6 -cycloalkyl), N (C 2
  • R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C 2 -C6-alkenyl, C 2 -C6-halogenalkenyl, C 2 -C6- alkynyl, C 2 -C6-halogenalkynyl, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl groups are unsubstituted or or carry one, two, three, four or five substituents selected from the group consisting of CN , halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 - halogenalkoxy;
  • R 4 wherein the acyclic moieties of R 4 are unsubstituted or substituted with groups R 4a which independently of one another are selected from:
  • R 4a halogen, OH , CN , d-Ce-alkoxy, C 3 -C6-cycloalkyl, C 3 -C6-halogencycloalkyl, Ci-C 4 - halogenalkoxy, Ci-C6-alkylthio, phenoxy; wherein the phenoxy group is unsubstituted or substituted with substituent R 41 a selected from the group consisting of halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogen- alkoxy;
  • R 4 wherein the carbocyclic, heteroaryl and aryl moieties of R 4 are unsubstituted or substituted with groups R 4b which independently of one another are selected from:
  • R 4b halogen, OH , CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy and Ci-C6-alkylthio.
  • novel compounds of the formula I having R 1 , R2, R 3 , R 5 , R 6 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 4 is in each case independently selected from halogen, OH , CN , N0 2 , SH , N H 2 , N H(Ci-C 4 - alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 2 -C 4 -alkenyl), N (C 2 -C 4 -alkenyl) 2 , N H(C 2 -C 4 -alkynyl), N (C 2 -C 4 - alkynyl) 2 , N H(C 3 -C 6 -cycloalkyl), N (C 3 -C 6 -cycloalkyl) 2 , N(Ci-C 4 -alkyl)(C 2 -C 4 -alkenyl), N (Ci- C 4 -alkyl)(C 2 -C 4 -alkynyl), N (Ci-C 4 -alkyl)(C 3 -C 6 -cycloalkyl), N
  • R Y is Ci-C6-alkyl, Ci-C6-halogenalkyl, C 2 -C6-alkenyl, C 2 -C6-halogenalkenyl, C 2 -C6- alkynyl, C 2 -C6-halogenalkynyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, phenyl and phenyl-Ci-C6-alkyl; wherein the phenyl groups are unsubstituted or or carry one, two, three, four or five substituents selected from the group consisting of CN, halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and C1-C4- halogenalkoxy;
  • R 4 wherein the acyclic moieties of R 4 are unsubstituted or substituted with groups R 4a which independently of one another are selected from:
  • R 4a halogen, OH, CN, d-Ce-alkoxy, Cs-Ce-cycloalkyl, Cs-Ce-halogencycloalkyl, C1-C4- halogenalkoxy, Ci-C6-alkylthio, aryl and phenoxy; wherein the aryl and phenoxy group is unsubstituted or substituted with substituent R 41a selected from the group consisting of halogen, OH, Ci-C4-alkyl, Ci-C4-halogenalkyl, Ci-C4-alkoxy and Ci-C4-halogenalkoxy;
  • R 4 wherein the carbocyclic, heteroaryl and aryl moieties of R 4 are unsubstituted or substituted with groups R 4b which independently of one another are selected from:
  • R 4b halogen, OH, CN, Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C4-halogenalkoxy and Ci-C6-alkylthio.
  • novel compounds of the formula I having R 1 , R 2 , R 3 , R 4 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 5 , R 6 together with the carbon atoms to which they are bound form a phenyl or five- or six membered heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein the phenyl or heteroaryl is substituted with (R 56 ) 0 , wherein
  • o 0, 1 , 2 or 3;
  • R' and R" are independently selected from H , Ci-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein R' and R" are independently unsubstituted or substituted with R'" which is independently selected from halogen, OH , CN, N0 2 , SH, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH-SO2- R x , Ci-C6-alkyl, Ci-C6-halogenalkyl, C2-C6-alkenyl, C2-C6-halogen
  • R 56 wherein the acyclic moieties of R 56 are not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R 56a which independently of one another are selected from:
  • R 56a halogen, OH, CN , Ci-C 6 -alkoxy, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, C 3 -C 6 - halogencycloalkyl, C3-C6-halogencycloalkenyl, Ci-C 4 -halogenalkoxy, Ci-C6-al- kylthio, five- or six-membered heteroaryl, phenyl and phenoxy; wherein the heteroaryl, phenyl and phenoxy group is unsubstituted or unsubstituted or substituted with R 561a selected from the group consisting of halogen, OH, Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 56 wherein the carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R 56 are unsubstituted or substituted with identical or different groups R 56b which independently of one another are selected from:
  • R 56b halogen, OH, CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C3-C6-halogencycloalkyl, Ci-C 4 -halogenalkoxy, and Ci-C6-alkylthio.
  • the novel compounds of the formula I having R 1 , R 2 , R 3 , R 4 , A, B, R 7 , R 8 and R 9 as defined above and
  • R 5 , R 6 together with the carbon atoms to which they are bound form a phenyl or five- or six membered heteroaryl; wherein the heteroaryl contains one, two or three heteroatoms selected from N, O and S, and wherein the phenyl or heteroaryl is substituted with (R 56 ) 0 , wherein
  • o 0, 1 , 2 or 3;
  • R' and R" are independently selected from H , Ci-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, saturated or partially unsaturated three-, four-, five-, six-, seven-, eight-, nine-, or ten-membered carbo- and heterocycle, five- or six-membered heteroaryl or aryl; wherein the heterocycle or heteroaryl contains one, two or three heteroatoms selected from N , O and S, and wherein R' and R" are independently unsubstituted or substituted with R'" which is independently selected from halogen, OH , CN , N0 2 , SH , N H 2 , N H(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , N H-SO2- R x , d-Ce-alkyl, d-Ce-halogenalkyl, C 2 -C 6 -alkenyl
  • R 56 wherein the acyclic moieties of R 56 are not further substituted or carry 1 , 2, 3 or up to the maximum possible number of identical or different groups R 56a which independently of one another are selected from:
  • R 56a halogen, OH , CN , Ci-C 6 -alkoxy, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, C 3 -C 6 - halogencycloalkyl, C3-C6-halogencycloalkenyl, Ci-C 4 -halogenalkoxy, Ci-C6-al- kylthio, five- or six-membered heteroaryl, phenyl and phenoxy; wherein the het- eroaryl, phenyl and phenoxy group is unsubstituted or unsubstituted or substituted with R 561 a selected from the group consisting of halogen, OH , Ci-C 4 -alkyl, Ci-C 4 -halogenalkyl, Ci-C 4 -alkoxy and Ci-C 4 -halogenalkoxy;
  • R 56 wherein the carbocyclic, phenyl, heterocyclic and heteroaryl moieties of R 56 are unsubstituted or substituted with identical or different groups R 56b which independently of one another are selected from:
  • R 56b halogen, OH , CN , Ci-C 4 -alkyl, Ci-C 4 -alkoxy, Ci-C 4 -halogenalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 - halogencycloalkyl, Ci-C 4 -halogenalkoxy, and Ci-C6-alkylthio.
  • Particular embodiments of the compounds I are the following compounds: l-A, l-B, l-C, l-D, l-E, l-F, l-G.
  • substituents B, R 4 , R 3 are independently as defined in claim 1 or preferably defined below:
  • Preferred embodiments of the present invention are the following compounds I.A-1 , I.A-2, I.A-3, I.A-4J.A-5, I.A-6, I.A-7, l-A-8; I.B-1 , I.B-2, I.B-3, I.B-4, I.B-5, I.B-6, I.B-7, I.B-8; I.C-1 , I.C-2, I.C-3, I.C-4 I.C-5, I.C-6, I.C-7, I.C-8; I.D-1 , I.D-2, I.D-3, I.D-4, I.D-5, I.D-6, I.D-7, I.D-8; I.E-1 , I.E-2, I.E- 3, I.E-4, I.E-5, I.E-6, I.E-7, I.E-8; I.F-1 , I.F-2, I.F-3, I.F-4, I.F-5, I.F-6, I.F-7, I.
  • Table 1-1 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is CH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-1.1-1.A-1 to I.
  • A-1.1-1.A-450 com- pounds I.B-1.1-1.A-1 to I.B-1.1-1.A-450, compounds I.C-1.1-1.A-1 to I.C-1.1-1.A-450, compounds I.D-1.1-1.A-1 to I.D-1.1-1.A-450, compounds I.E-1.1-1.A-1 to I.E-1.1-1.A-450, compounds I.F-1.1-1.A-1 to I.F-1.1-1.A-450, compounds I.G-1.1-1.A-1 to I.G-1.1-1.A-450).
  • Table 1-2 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is CH2F and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corre- sponds in each case to one line of Table A (compounds I.A-1.1-2.A-1 to I.A-1.1-2.A-450, compounds I.B-1.1-2.A-1 to I.B-1.1-2.
  • A-450 compounds I.C-1.1-2.A-1 to I.C-1.1-2.A-450, compounds I.D-1.1-2.A-1 to I.D-1.1-2.A 50, compounds I.E-1.1-2.A-1 to I.E-1.1-2. A-450, compounds I.F-1.1-2.A-1 to I.F-1.1-2.A-450, compounds I.G-1.1-2.A-1 to I.G-1.1-2.A-450).
  • Table 1-3 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is CHF2 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-1.1-3.A-1 to I.A-1.1-3.A-450, compounds I.B-1.1-3.A-1 to I.B-1.1-3.A-450, compounds I.C-1.1-3.A-1 to I.C-1.1-3.A-450, compounds I.D-1.1-3.A-1 to I.D-1.1-3.A-450, compounds I.E-1.1-3.A-1 to I.E-1.1-3.A-450, com- pounds I.F-1.1-3.A-1 to I.F-1.1-3.A-450, compounds I.G-1.1 -3.A-1 to I.G-1.1-3.A-450).
  • Table 1-4 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is CF3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-1.1-4.A-1 to I.A-1.1-4.A-450, compounds I.B-1.1-4.A-1 to I.B-1.1-4.A-450, compounds I.C-1.1-4.A-1 to I.C-1.1-4.A-450, com- pounds I.D-1.1-4.A-1 to I.D-1.1-4.A-450, compounds I.E-1.1-4.A-1 to I.E-1.1-4. A-450, compounds I.F-1.1-4.A-1 to I.F-1.1-4.A-450, compounds I.G-1.1-4.A-1 to I.G-1.1-4.A-450).
  • Table 1-5 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is CI and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-1.1-5.A-1 to I.A-1.1-5.A-450, com- pounds I.B-1.1-5.A-1 to I.B-1.1-5.A-450, compounds I.C-1.1-5.A-1 to I.C-1.1-5.A-450, compounds I.D-1.1-5.A-1 to I.D-1.1-5.A-450, compounds I.E-1.1-5.A-1 to I.E-1.1-5.A-450, compounds I.F-1.1-5.A-1 to I.F-1.1-5.A-450, compounds I.G-1.1-5.A-1 to I.G-1.1-5.A-450).
  • Table 1-6 Compounds of the formula I.A-1, I.B-1, I.C-1, I.D-1, I.E-1, I.F-1, I.G-1 in which R 3 is OCH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corre- sponds in each case to one line of Table A (compounds I.A-1.1-6.A-1 to I.A-1.1-6.A-450, compounds I.B-1.1-6.A-1 to I.B-1.1-6.A-450, compounds I.C-1.1-6.A-1 to I.C-1.1-6.A-450, compounds I.D-1.1-6.A-1 to I.D-1.1-6.A-450, compounds I.E-1.1-6.A-1 to I.E-1.1-6.A-450, compounds I.F-1.1-6.A-1 to I.F-1.1-6.A-450, compounds I.G-1.1-6.A-1 to I.G-1.1-6.A-450).
  • Table 2-1 Compounds of the formula I.A-2, I.B-2, I.C-2, I.D-2, I.E-2, I.F-2, I.G-2 in which R 3 is CH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-1.A-1 to I.A-2.2-1.A-450, compounds I.B-2.2-1.A-1 to I.B-2.2-1.A-450, compounds I.C-2.2-1.A-1 to I.C-2.2-1.A-450, compounds I.D-2.2-1.A-1 to I.D-2.2-1.A-450, compounds I.E-2.2-1.A-1 to I.E-2.2-1.A-450, compounds I.F-2.2-1.A-1 to I.F-2.2-1.A-450, compounds I.G-2.2-1.A-1 to I.G-2.2-1.A-450).
  • Table 2-2 Compounds of the formula I.A-2, I.B-2, I.C-2, I.D-2, I.E-2, I.F-2, I.G-2 in which R 3 is CH2F and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-2.A-1 to I.A-2.2-2.A-450, compounds I.B-2.2-2.A-1 to I.B-2.2-2. A-450, compounds I.C-2.2-2.A-1 to I.C-2.2-2.A-450, compounds I.D-2.2-2.A-1 to I.D-2.2-2.A-450, compounds I.E-2.2-2.A-1 to I.E-2.2-2. A-450, com- pounds I.F-2.2-2.A-1 to I.F-2.2-2.A-450, compounds I.G-2.2-2.A-1 to I.G-2.2-2.A-450).
  • Table 2-3 Compounds of the formula I.A-2, I.B-2, I.C-2, I.D-2, I.E-2, I.F-2, I.G-2 in which R 3 is CHF2 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-3.A-1 to I.A-2.2-3.A-450, compounds I.B-2.2-3.A-1 to I.B-2.2-3.A-450, compounds I.C-2.2-3.A-1 to I.C-2.2-3.A-450, com- pounds I.D-2.2-3.A-1 to I.D-2.2-3.A-450, compounds I.E-2.2-3.A-1 to I.E-2.2-3. A-450, compounds I.F-2.2-3.A-1 to I.F-2.2-3.A-450, compounds I.G-2.2-3.A-1 to I.G-2.2-3.A-450).
  • Table 2-4 Compounds of the formula I.A-2, I.B-2, I.C-2, I.D-2, I.E-2, I.F-2, I.G-2 in which R 3 is CF3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-4.A-1 to I.A-2.2-4.A-450, compounds I.B-2.2-4.A-1 to I. B-2.2-4. A-450, compounds I.C-2.2-4.A-1 to I.C-2.2-4.A-450, compounds I.D-2.2-4.A-1 to I.D-2.2-4.A-450, compounds I.E-2.2-4.A-1 to I. E-2.2-4. A-450, com- pounds I.F-2.2-4.A-1 to I.F-2.2-4.A-450, compounds I.G-2.2-4.A-1 to I.G-2.2-4.A-450).
  • Table 2-5 Compounds of the formula I.A-2, I. B-2, I.C-2, I.D-2, I. E-2, I.F-2, I.G-2 in which R 3 is CI and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-5.A-1 to I.A-2.2-5.A-450, compounds I.B-2.2-5.A-1 to I.B-2.2-5.A-450, compounds I.C-2.2-5.A-1 to I.C-2.2-5.A-450, com- pounds I.D-2.2-5.A-1 to I.D-2.2-5.A-450, compounds I.E-2.2-5.A-1 to I.E-2.2-5.A-450, compounds I.F-2.2-5.A-1 to I.F-2.2-5.A-450, compounds I.G-2.2-5.A-1 to I.G-2.2-5.A-450).
  • Table 2-6 Compounds of the formula I.A-2, I. B-2, I.C-2, I.D-2, I. E-2, I.F-2, I.G-2 in which R 3 is OCH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-2.2-6.A-1 to I.A-2.2-6.A-450, com- pounds I.B-2.2-6.A-1 to I.B-2.2-6.A-450, compounds I.C-2.2-6.A-1 to I.C-2.2-6.A-450, compounds I.D-2.2-6.A-1 to I.D-2.2-6.A-450, compounds I.E-2.2-6.A-1 to I.E-2.2-6.A-450, compounds I.F-2.2-6.A-1 to I.F-2.2-6.A-450, compounds I.G-2.2-6.A-1 to I.G-2.2-6.A-450).
  • Table 3-1 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is CH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corre- sponds in each case to one line of Table A (compounds I.A-3.3-1 .A-1 to I.A-3.3-1.A-450, compounds I.B-3.3-1.A-1 to I.B-3.3-1 .A-450, compounds I.C-3.3-1 .A-1 to I.C-3.3-1 .A-450, compounds I.D-3.3-1 .A-1 to I.D-3.3-1 .A-450, compounds I.E-3.3-1.A-1 to I.E-3.3-1 .A-450, compounds I.F-3.3-1 .A-1 to I.F-3.3-1.A-450, compounds I.G-3.3-1.A-1 to I.G-3.3-1.A-450).
  • Table 3-2 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is CH2F and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-3.3-2.A-1 to I.A-3.3-2.A-450, compounds I.B-3.3-2.A-1 to I.B-3.3-2.A-450, compounds I.C-3.3-2.A-1 to I.C-3.3-2.A-450, compounds I.D-3.3-2.A-1 to I.D-3.3-2.
  • A-450 compounds I.E-3.3-2.A-1 to I.E-3.3-2.A-450, compounds I.F-3.3-2.A-1 to I.F-3.3-2. A-450, compounds I.G-3.3-2.A-1 to I.G-3.3-2.A-450).
  • Table 3-3 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is CHF2 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-3.3-3.A-1 to I.A-3.3-3.A-450, compounds I.B-3.3-3.A-1 to I.B-3.3-3.A-450, compounds I.C-3.3-3.A-1 to I.C-3.3-3.A-450, compounds I.D-3.3-3.A-1 to I.D-3.3-3.
  • Table 3-4 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is CF3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-3.3-4.A-1 to I.A-3.3-4.A-450, compounds I.B-3.3-4.A-1 to I.B-3.3-4.A-450, compounds I.C-3.3-4.A-1 to I.C-3.3-4.A-450, com- pounds I.D-3.3-4.A-1 to I.D-3.3-4.
  • A-450 compounds I.E-3.3-4.A-1 to I.E-3.3-4.A-450, compounds I.F-3.3-4.A-1 to I.F-3.3-4. A-450, compounds I.G-3.3-4.A-1 to I.G-3.3-4.A-450).
  • Table 3-5 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is CI and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-3.3-5.A-1 to I.A-3.3-5.A-450, compounds I.B-3.3-5.A-1 to I.B-3.3-5.A-450, compounds I.C-3.3-5.A-1 to I.C-3.3-5.A-450, compounds I.D-3.3-5.A-1 to I.D-3.3-5.A-450, compounds I.E-3.3-5.A-1 to I.E-3.3-5.A-450, com- pounds I.F-3.3-5.A-1 to I.F-3.3-5.A-450, compounds I.G-3.3-5.A-1 to I.G-3.3-5.A-450).
  • Table 3-6 Compounds of the formula I.A-3, I.B-3, I.C-3, I.D-3, I.E-3, I.F-3, I.G-3 in which R 3 is OCH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-3.3-6.A-1 to I.A-3.3-6.A-450, compounds I.B-3.3-6.A-1 to I.B-3.3-6.A-450, compounds I.C-3.3-6.A-1 to I.C-3.3-6.A-450, com- pounds I.D-3.3-6.A-1 to I.D-3.3-6.
  • Table 4-1 Compounds of the formula I.A-4, I.B-4, I.C-4, I.D-4, I.E-4, I.F-4, I.G-4 in which R 3 is CH3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corre- sponds in each case to one line of Table A (compounds I.A-4.4-1 .A-1 to I.A-4.4-1.A-450, compounds I.B-4.4-1.A-1 to I.B-4.4-1 .A-450, compounds I.C-4.4-1 .A-1 to I.C-4.4-1 .A-450, compounds I.D-4.4-1 .A-1 to I.D-4.4-1 .A-450, compounds I.E-4.4-1.A-1 to I.E-4.4-1 .A-450, compounds I.F-4.4-1 .A-1 to I.F-4.4-1.A-450, compounds I.G-4.4-1.A-1 to I.G-4.4-1.A-450).
  • Table 4-2 Compounds of the formula I.A-4, I.B-4, I.C-4, I.D-4, I.E-4, I.F-4, I.G-4 in which R 3 is CH2F and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-4.4-2.A-1 to I.A-4.4-2.A-450, compounds I.B-4.4-2.A-1 to I.B-4.4-2. A-450, compounds I.C-4.4-2.A-1 to I.C-4.4-2.A-450, compounds I.D-4.4-2.A-1 to I.D-4.4-2.A-450, compounds I.E-4.4-2.A-1 to I.E-4.4-2. A-450, compounds I.F-4.4-2.A-1 to I.F-4.4-2.A-450, compounds I.G-4.4-2.A-1 to I.G-4.4-2.A-450).
  • Table 4-3 Compounds of the formula I.A-4, I.B-4, I.C-4, I.D-4, I.E-4, I.F-4, I.G-4 in which R 3 is CHF2 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-4.4-3.A-1 to I.A-4.4-3.A-450, compounds I.B-4.4-3.A-1 to I.B-4.4-3.A-450, compounds I.C-4.4-3.A-1 to I.C-4.4-3.A-450, compounds I.D-4.4-3.A-1 to I.D-4.4-3.A-450, compounds I.E-4.4-3.A-1 to I.E-4.4-3. A-450, com- pounds I.F-4.4-3.A-1 to I.F-4.4-3.A-450, compounds I.G-4.4-3.A-1 to I.G-4.4-3.A-450).
  • Table 4-4 Compounds of the formula I.A-4, I.B-4, I.C-4, I.D-4, I.E-4, I.F-4, I.G-4 in which R 3 is CF3 and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-4.4-4.A-1 to I.A-4.4-4.A-450, compounds I.B-4.4-4.A-1 to I.B-4.4-4.
  • A-450 compounds I.C-4.4-4.A-1 to I.C-4.4-4.A-450, com- pounds I.D-4.4-4.A-1 to I.D-4.4-4.A-450, compounds I.E-4.4-4.A-1 to I.E-4.4-4. A-450, compounds I.F-4.4-4.A-1 to I.F-4.4-4.A-450, compounds I.G-4.4-4.A-1 to I.G-4.4-4.A-450).
  • Table 4-5 Compounds of the formula I.A-4, I.B-4, I.C-4, I.D-4, I.E-4, I.F-4, I.G-4 in which R 3 is CI and the meaning for the combination of R 4 , R 7 and R 8 for each individual compound corresponds in each case to one line of Table A (compounds I.A-4.4-5.A-1 to I.A-4.4-5.A-450, com- pounds I.B-4.4-5.A-1 to I.B-4.4-5.A-450, compounds I.C-4.4-5.A-1 to I.C-4.4-5.A-450, compounds I.D-4.4-5.A-1 to I.D-4.4-5.A-450, compounds I.E-4.4-5.A-1 to I.E-4.4-5.A-450, compounds I.F-4.4-5.A-1 to I.F-4.4-5.A-450, compounds I.G-4.4-5.A-1 to I.G-4.4-5.A-450).

Abstract

La présente invention concerne l'utilisation de composés de formule (I) dans laquelle les variables sont telles que définies dans la description et les revendications. L'invention concerne également de nouveaux composés et compositions pour les composés de formule (I).
PCT/EP2018/053332 2017-02-16 2018-02-09 Composés de pyridine WO2018149754A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11425910B2 (en) 2017-02-21 2022-08-30 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US11839214B2 (en) 2017-12-15 2023-12-12 Basf Se Fungicidal mixture comprising substituted pyridines

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