WO2018143666A3 - Cap1로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 약학적 조성물 - Google Patents
Cap1로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 약학적 조성물 Download PDFInfo
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- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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Abstract
본 발명은 CAP1로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 약 학적 조성물에 관한 것으로, 보다 상세하게는 서열번호 1의 아미노산 서열을 포함 하며, 상기 서열의 N말단에 임의의 아미노산이 0 내지 20개, C말단에 임의의 아미 노산이 0 내지 75개의 부가된 아미노산 서열로 이루어진 펩타이드 및 상기 펩타이 드를 유효성분으로 포함하는 염증성 질환 예방 및 개선용, 항암 및 암 전이 억제 용, 당뇨병 예방 및 개선용, 동맥경화증 또는 심혈관질환 예방 및 개선용, 심부전 예방 및 개선용 약학적 조성물에 관한 것이다. 본 발명의 방법은 레지스틴과 CAP1의 결합을 억제하는 효과. NF-kB 활성을 저해하는 효과가 있어 레지스틴의 활성화 및 NF-kB 활성화로 인한 염증성 질환, 암, 당뇨병, 동맥경화증, 심혈관질환, 심부전 등을 치료하는 데에 유용하게 사용될 수 있다.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/482,333 US11091515B2 (en) | 2017-01-31 | 2018-01-31 | Polypeptide derived from CAP1 and pharmaceutical composition comprising same as effective ingredient |
US17/368,090 US20220033452A1 (en) | 2017-01-31 | 2021-07-06 | Polypeptide derived from cap1 and pharmaceutical composition comprising same as effective ingredient |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2017-0014128 | 2017-01-31 | ||
KR1020170014128A KR102040974B1 (ko) | 2017-01-31 | 2017-01-31 | Cap1로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 약학적 조성물 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/482,333 A-371-Of-International US11091515B2 (en) | 2017-01-31 | 2018-01-31 | Polypeptide derived from CAP1 and pharmaceutical composition comprising same as effective ingredient |
US17/368,090 Continuation-In-Part US20220033452A1 (en) | 2017-01-31 | 2021-07-06 | Polypeptide derived from cap1 and pharmaceutical composition comprising same as effective ingredient |
Publications (2)
Publication Number | Publication Date |
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WO2018143666A2 WO2018143666A2 (ko) | 2018-08-09 |
WO2018143666A3 true WO2018143666A3 (ko) | 2018-10-04 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/KR2018/001332 WO2018143666A2 (ko) | 2017-01-31 | 2018-01-31 | Cap1로부터 유래된 폴리펩티드 및 이를 유효성분으로 포함하는 약학적 조성물 |
Country Status (3)
Country | Link |
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US (1) | US11091515B2 (ko) |
KR (1) | KR102040974B1 (ko) |
WO (1) | WO2018143666A2 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102288716B1 (ko) * | 2019-10-30 | 2021-08-12 | 경상남도 | 항비만 효능을 갖는 펩타이드 및 이의 용도 |
AU2020433744A1 (en) * | 2020-03-02 | 2022-09-22 | Seoul National University Hospital | Pharmaceutical composition for lowering blood cholesterol, preventing or treating cardiovascular diseases and reducing inflammation |
KR102335886B1 (ko) * | 2020-03-11 | 2021-12-07 | 서울대학교병원 | 엘리오카퍼스 페티오라투스를 포함하는 심혈관 대사 질환의 예방 또는 치료용 조성물 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004034062A2 (en) * | 2002-10-08 | 2004-04-22 | Oxford Glycosciences (Uk) Ltd | Use of cap-1 for the therapy of asthma |
US20120014973A1 (en) * | 2009-03-30 | 2012-01-19 | Protab Ltd. | Adenylyl cyclase-associated protein (cap1) and uses thereof as a target for immuno-modulation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2162535A4 (en) * | 2007-06-04 | 2011-02-23 | Novo Nordisk As | O-linked glycosylation using N-acetylglucosamine transferases |
WO2013022262A2 (ko) * | 2011-08-08 | 2013-02-14 | 서울대학교병원 | 인간 리지스틴 수용체 및 그 용도 |
KR101473526B1 (ko) | 2011-08-08 | 2014-12-22 | 서울대학교병원 | 인간 리지스틴 수용체 및 그 용도 |
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2017
- 2017-01-31 KR KR1020170014128A patent/KR102040974B1/ko active IP Right Grant
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2018
- 2018-01-31 WO PCT/KR2018/001332 patent/WO2018143666A2/ko active Application Filing
- 2018-01-31 US US16/482,333 patent/US11091515B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004034062A2 (en) * | 2002-10-08 | 2004-04-22 | Oxford Glycosciences (Uk) Ltd | Use of cap-1 for the therapy of asthma |
US20120014973A1 (en) * | 2009-03-30 | 2012-01-19 | Protab Ltd. | Adenylyl cyclase-associated protein (cap1) and uses thereof as a target for immuno-modulation |
Non-Patent Citations (3)
Title |
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DATABASE Protein [O] 16 October 2008 (2008-10-16), "CAP1 [Homo sapiens]", XP055559898, retrieved from cbi Database accession no. CAG33690.1 * |
FREEMAN, N. L. ET AL.: "A Conserved Proline-rich Region of the Saccharomyces Cerevisiae Cyclase-associated Protein Binds SH3 Domains and Modulates Cytoskeletal Localization", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 2, February 1996 (1996-02-01), pages 548 - 556, XP055559902 * |
LEE, S. ET AL.: "Adenylyl Cyclase-associated Protein 1 Is a Receptor for Human Resistin and Mediates Inflammatory Actions of Human Monocytes", CELL METABOLISM, vol. 19, no. 3, March 2014 (2014-03-01), pages 484 - 497, XP055559906 * |
Also Published As
Publication number | Publication date |
---|---|
KR20180089253A (ko) | 2018-08-08 |
US11091515B2 (en) | 2021-08-17 |
WO2018143666A2 (ko) | 2018-08-09 |
US20200157147A1 (en) | 2020-05-21 |
KR102040974B1 (ko) | 2019-11-06 |
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