WO2018139099A1 - Analysis-cell disposal container, disposable analysis cell, and analysis-cell disposable kit - Google Patents

Analysis-cell disposal container, disposable analysis cell, and analysis-cell disposable kit Download PDF

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Publication number
WO2018139099A1
WO2018139099A1 PCT/JP2017/045014 JP2017045014W WO2018139099A1 WO 2018139099 A1 WO2018139099 A1 WO 2018139099A1 JP 2017045014 W JP2017045014 W JP 2017045014W WO 2018139099 A1 WO2018139099 A1 WO 2018139099A1
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Prior art keywords
analysis
analysis cell
cell
coupled
coupling
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PCT/JP2017/045014
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French (fr)
Japanese (ja)
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典弘 松山
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株式会社ダナフォーム
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present invention relates to an analysis cell disposal container, a disposal analysis cell, and an analysis cell disposal kit.
  • the analysis cell that has been analyzed contains the biological sample, and depending on the biological sample, there may be cases in which an analyzer or an object that pollutes the environment such as a laboratory in which analysis is performed is included. is there.
  • an analyzer or an object that pollutes the environment such as a laboratory in which analysis is performed is included.
  • the analyst may be secondaryly infected by contact with the analysis cell.
  • a detection system that performs nucleic acid amplification for example, if the amplified product after the analysis leaks out of the system, there is a possibility that subsequent detection performed near the leakage area may be disabled.
  • an object of the present invention is to provide a tool for safely discarding an analysis cell after completion of analysis, for example, regardless of the risk level of a sample to be analyzed.
  • the analysis cell waste container of the present invention comprises: A storage chamber, a coupling portion and a coupling release portion;
  • the containment chamber is Having a storage space for the analysis cell; Has an openable and closable opening,
  • the coupling portion is It is a coupling part that can be coupled with the analysis cell,
  • the uncoupling part is A release unit capable of releasing the coupling between the analysis cell and the analysis device; while using it, In the state where the opening of the storage chamber is opened, the analysis cell in a state inserted into the analysis device is stored inside the storage chamber, Combined with the analysis cell by the combining unit, Release the coupling between the analysis cell and the analysis device by the coupling release unit, Pull out the analytical device from the containment chamber, The opening of the storage chamber is closed in a state where the analysis cell is stored in the storage chamber.
  • the disposal analysis cell of the present invention has an analyzed part, a first coupled part, and a second coupled part,
  • the first coupled portion is A coupled portion that can be coupled to an analytical device;
  • the second coupled portion is It is a coupled part that can be coupled with the analysis cell waste container, At the start of analysis, The first coupled portion is coupled to the analysis device, After the analysis The second coupled part is coupled to the coupling part of the analysis cell disposal container, The coupling with the analysis device in the first coupled part is released by the coupling releasing part of the analysis cell disposal container.
  • the analysis cell disposal kit of the present invention includes the analysis cell waste container of the present invention and the analysis cell of the present invention.
  • the analysis device of the present invention includes a coupling unit and an analysis unit, and the coupling unit is a coupling unit that can be coupled to the first coupled unit of the analysis cell of the present invention.
  • an analyst can discard the analysis cell without directly touching the analysis cell after completion of the analysis and without exposing the analysis cell to the analysis environment. For this reason, high safety can be ensured.
  • FIG. 1 is a perspective view illustrating an example of an analysis cell and an analysis device according to the first embodiment.
  • FIG. 2 is a perspective view showing an outline of an analysis cell waste container and a method for using the same in the first embodiment.
  • FIG. 3 is a plan view illustrating an outline of an example of an analysis cell, an analysis device, and an analysis cell waste container in the second embodiment.
  • FIG. 4 is a plan view schematically showing a method for using the analysis cell waste container in the second embodiment.
  • FIG. 5 is a plan view showing an outline of a method of using the analysis cell waste container in the second embodiment.
  • the coupling unit also serves as the releasing unit, and the coupling unit is coupled to the analysis cell, and the coupling between the analysis cell and the analysis device is released. .
  • the storage chamber has a bag shape.
  • the storage chamber is flexible.
  • the opening of the storage chamber has a chuck portion, and can be opened and closed by the chuck portion.
  • the storage chamber has a gripping portion at the other end of the opening.
  • the grip portion is a handle type.
  • Embodiment 1 demonstrates an example of an analysis cell disposal container using a figure.
  • the analysis cell 10 has a gripping portion 101 and an analysis substrate 102.
  • the gripping portion 101 has a portion 104 to be coupled to an analysis cell disposal container described later.
  • a plurality of reaction units 103 In each of the plurality of reaction units 103, for example, a part or all of the reaction units 103 are analyzed units analyzed by the analysis device.
  • the analysis device 20 has a storage chamber 201 that stores the analysis cell 10. When the sample is added to the reaction unit 103 of the analysis cell 10 in use, the analysis cell 10 is inserted into the storage chamber 201 of the analysis device 20 as shown in FIG. As shown in FIG. 2, the analysis substrate 102 of the analysis cell 10 is accommodated in the accommodation chamber 201 of the analysis device 20 and reacted.
  • FIG. 2 is a perspective view schematically showing the use of the analysis cell waste container 30 and the analysis cell waste container 30.
  • the analysis cell waste container 30 has a storage chamber 301.
  • the storage chamber 301 has a bag shape with one open, and has an openable / closable chuck portion 303 on the opening 302 side.
  • the storage chamber 301 has a storage space in which the analysis cell 10 inserted in the analysis device 20 can be stored.
  • the storage chamber 301 has a fixing portion 306 on the side opposite to the opening 302, and a holding portion 305 is fixed to the fixing portion 306 toward the outside of the storage chamber 301, and toward the inside of the storage chamber 301.
  • the coupling portion 304 is fixed.
  • the grip 305 is a handle type and is a part for facilitating the handling of the analysis cell waste container 30.
  • the coupling unit 304 serves as a coupling unit that can be coupled to the analysis cell 10 and a release unit that can decouple the analysis cell 10 and the analysis device 20.
  • the analysis cell 10 is accommodated in the accommodation chamber 301 while being inserted into the analysis device 20 from the opening 302 of the analysis cell disposal container 30.
  • the analysis cell disposal container 30 and the analysis cell 10 are fixed by coupling the coupling portion 304 of the analysis cell disposal container 30 with the coupled portion 104 of the analysis cell 10, and the analysis cell 10 and the analysis device are fixed. 20 is released.
  • the mechanism for coupling with the analysis cell 10 and the coupling release between the analysis cell 10 and the analysis device 20 by the coupling unit 304 of the analysis cell disposal container 30 is not particularly limited. An example of the mechanism will be described later.
  • the analysis cell disposal container 30 is coupled to the analysis cell 10 by the coupling unit 304, and the coupling between the analysis cell 10 and the analysis device 20 is released. Therefore, as shown in FIG. 2C, by pulling the grip portion 305 of the analysis cell waste container 30 in the direction opposite to the analysis device 20, the analysis cell waste container 30 and the analysis cell 10 coupled thereto are obtained. Separate from the analysis device 20. As a result, the analysis cell 10 is accommodated in the accommodation chamber 301 of the analysis cell disposal container 30 as shown in FIG. Then, as shown in FIG. 2D, the chuck of the analysis cell waste container 30 is closed. As a result, the analysis cell 10 can be discarded while being stored in the storage chamber 301 of the analysis cell disposal container 30 without being exposed to the outside. Thereby, for example, the amplified product after analysis can be prevented from leaking out of the system.
  • the analysis cell disposal container 30 accommodates the analysis cell 10 in a state of being coupled to the analysis device 20 in the storage chamber 301, and after separating the analysis device 20 from the analysis cell 10, the opening 302 is formed in the chuck portion 303. Need to close.
  • the storage chamber 301 is preferably formed of, for example, a flexible material.
  • the flexible material include polyolefins such as polyethylene, polypropylene, polytetrafluoroethylene, and polybutylene terephthalate; polyvinyl chloride such as soft polyvinyl chloride; polyvinyl alcohol; ethylene-vinyl acetate copolymer resin; silicon; Examples thereof include resins such as nylon.
  • the storage chamber 301 is preferably a transparent member or a translucent member so that the inside can be confirmed, for example.
  • the opening 302 of the analysis cell disposal container 30 only needs to be openable and closable.
  • the opening and closing is performed by the chuck portion 303 as described above.
  • the opening and closing by the chuck portion 303 is, for example, a slide type.
  • the type of the analysis cell 10 is not particularly limited, and examples thereof include cells used for nucleic acid amplification reaction systems, antigen-antibody reaction systems, and the like.
  • Embodiment 2 demonstrates an example of the mechanism of the coupling
  • FIG. 3 to 4 are schematic views showing a coupling and decoupling mechanism between the analysis cell, the analysis device, and the analysis cell waste container.
  • FIG. 3 is a plan view schematically showing an analysis cell, an analysis device, and an analysis cell waste container. 3 and 4 are for the purpose of explaining the outline of the mechanism, and the other configurations are omitted.
  • FIG. 3A is a plan view of the analysis cell 10, and a pair of coupled portions 104 for coupling to the analysis device 20 and the analysis cell waste container 30 at both ends in the direction perpendicular to the coupling direction to the analysis device 20.
  • the coupled portion 104 is concave.
  • FIG. 3B is a plan view of the analysis device 20, and has a pair of coupling portions 204 for coupling with the analysis cell 10 at both ends in the direction perpendicular to the coupling direction with the analysis cell 10.
  • the pair of coupling portions 204 has a hook portion 204a with respect to the inner direction at one end and a fulcrum 204b fixed at the other end.
  • FIG. 3C is a plan view of the analysis cell waste container 30, which is coupled to the analysis cell 10 at both ends in the direction perpendicular to the coupling direction to the analysis cell 10, and the analysis cell 10 and the analysis device. 20 has a pair of coupling portions 304 for releasing the coupling with the unit 20.
  • the pair of coupling portions 304 has a hooking portion 304a for the inner direction at one end.
  • the analysis cell 10 is coupled to the analysis device 20. As shown in FIGS. 4A and 4B, the analysis cell 10 is inserted into the analysis device 20 in the direction of the arrow. When the analysis cell 10 is completely inserted into the analysis device 20, the hook portion 204 a of the coupling portion 204 of the analysis device 20 is hooked on the concave coupled portion 104 of the analysis cell 10, and the analysis cell 10 is attached to the analysis device 20. Fixed.
  • an analysis cell waste container 30 is prepared for the analysis cell 10 fixed to the analysis device 20 shown in FIG. 4C, and as shown in FIG.
  • the analysis cell waste container 30 is put on the analysis cell 10 fixed in the analysis device 20.
  • the tip of the coupling portion 304 of the analysis cell disposal container 30 hits the tip of the hook portion 204a of the coupling portion 204 in the analysis device 20, and the concave coupled portion of the analysis cell 10 is obtained.
  • 104 and the hooking part 204a of the analysis device 20 are released.
  • the hooking portion 304a of the coupling portion 304 in the analysis cell disposal container 30 is hooked on the concave coupled portion 104 of the analysis cell 10, and the analysis cell 10 is released from the coupling with the analysis device 20, and the analysis cell disposal container 30 is fixed.
  • the analysis device 20 is gripped and the analysis cell waste container 30 is pulled in the direction of the arrow, so that the analysis device 20 is fixed to the analysis cell waste container 30.
  • the analyzed analysis cell 10 can be pulled out. Since the extracted analysis cell 10 is stored in the storage chamber 301 of the analysis cell disposal container 30, it can be discarded without being exposed to the outside by closing the opening 302 as described above.
  • the release of the connection between the analysis device 20 and the analysis cell 10 is not limited to these embodiments, and may be released by, for example, a dedicated lock release device.
  • the unlocking device hits the tip of the hooking portion 204a of the coupling portion 204 in the analysis device 20 in the same manner as the tip of the coupling portion 304 of the analysis cell disposal container 30, and the concave coupled portion of the analysis cell 10 is connected.
  • the part 104 and the hooking part 204a of the analysis device 20 may have a part that releases the hook.
  • an analyzer can discard the analysis cell without directly touching the analysis cell after completion of the analysis and without exposing the analysis cell to the analysis environment. For this reason, high safety can be ensured.

Abstract

Provided is a tool for safely disposing of an analysis cell after completion of analysis regardless of the danger level of a sample that is analyzed. An analysis-cell disposal container according to the present invention is characterized by including an accommodation chamber, an engaging part, and an engagement releasing part, and is characterized in that the accommodation chamber includes a space for accommodating an analysis cell and has an opening that can be opened and closed, the engaging part is an engaging part that can be engaged with the analysis cell, the engagement releasing part is a releasing part that can release the mutual engagement of the analysis cell and an analysis device, and when in use, with the opening of the accommodation chamber opened, the analysis cell inserted into the analysis device is accommodated inside the accommodation chamber, the analysis cell is brought into engagement by using the engaging part, the mutual engagement of the analysis cell and the analysis device is released by using the engagement releasing part, the analysis device is withdrawn from the accommodation chamber, and with the analysis cell accommodated in the accommodation chamber, the opening of the accommodation chamber is closed.

Description

分析セル廃棄容器、ディスポーザル分析セル、および、分析セルのディスポーザルキットAnalysis cell disposal container, disposal analysis cell, and analysis cell disposal kit
　本発明は、分析セル廃棄容器、ディスポーザル分析セル、および、分析セルのディスポーザルキットに関する。 The present invention relates to an analysis cell disposal container, a disposal analysis cell, and an analysis cell disposal kit.
　近年、遺伝子検査において、ディスポーザルの分析セルを使用して、分析デバイスにより分析を行う形態が一般化している。通常、生体試料を分析セルに添加し、前記分析セルを前記分析デバイスにセットし、核酸増幅反応等を行い、その反応が分析される。そして、分析が終了すると、前記分析デバイスから、前記分析セルを取り出し、前記分析セルを廃棄する。 In recent years, in genetic testing, a form of performing analysis using an analysis device using a disposable analysis cell has become common. Usually, a biological sample is added to an analysis cell, the analysis cell is set in the analysis device, a nucleic acid amplification reaction or the like is performed, and the reaction is analyzed. When the analysis is completed, the analysis cell is taken out from the analysis device, and the analysis cell is discarded.
　しかしながら、分析が終了した前記分析セルは、前記生体試料を含んでおり、前記生体試料によっては、分析者や分析が行われている実験室等の環境を汚染するものが含まれている場合がある。例えば、前記生体試料が、ＨＩＶ、肝炎ウイルス、インフルエンザウイルス等に感染している場合、前記分析セルとの接触により、分析者が二次感染するおそれもある。また、核酸増幅を行う検出系の場合、例えば、分析終了後の増幅産物が系外に漏出すると、漏出エリア付近で行われる、それ以降の検出も不能になるおそれもある。 However, the analysis cell that has been analyzed contains the biological sample, and depending on the biological sample, there may be cases in which an analyzer or an object that pollutes the environment such as a laboratory in which analysis is performed is included. is there. For example, when the biological sample is infected with HIV, hepatitis virus, influenza virus, etc., the analyst may be secondaryly infected by contact with the analysis cell. Further, in the case of a detection system that performs nucleic acid amplification, for example, if the amplified product after the analysis leaks out of the system, there is a possibility that subsequent detection performed near the leakage area may be disabled.
　そこで、本発明は、例えば、分析対象の試料の危険度にかかわらず、安全に、分析終了後の分析セルを廃棄するためのツールを提供することを目的とする。 Therefore, an object of the present invention is to provide a tool for safely discarding an analysis cell after completion of analysis, for example, regardless of the risk level of a sample to be analyzed.
　前記目的を達成するために、本発明の分析セル廃棄容器は、
収容室と結合部と結合解除部とを有し、
前記収容室は、
　分析セルの収容空間を有し、
　開閉可能な開口部を有し、
前記結合部は、
　分析セルと結合可能な結合部であり、
前記結合解除部は、
　前記分析セルと分析デバイスとの結合を解除可能な解除部であり、
使用時、
　前記収容室の開口部を開口した状態で、前記収容室の内部に、前記分析デバイスに挿入された状態の前記分析セルを収容し、
　前記結合部により、前記分析セルと結合し、
　前記結合解除部により、前記分析セルと前記分析デバイスとの結合を解除し、
前記収容室から、前記分析デバイスを引き抜き、
　前記収容室に前記分析セルが収容された状態で、前記収容室の前記開口部を閉じることを特徴とする。 In order to achieve the above object, the analysis cell waste container of the present invention comprises:
A storage chamber, a coupling portion and a coupling release portion;
The containment chamber is
Having a storage space for the analysis cell;
Has an openable and closable opening,
The coupling portion is
It is a coupling part that can be coupled with the analysis cell,
The uncoupling part is
A release unit capable of releasing the coupling between the analysis cell and the analysis device;
while using it,
In the state where the opening of the storage chamber is opened, the analysis cell in a state inserted into the analysis device is stored inside the storage chamber,
Combined with the analysis cell by the combining unit,
Release the coupling between the analysis cell and the analysis device by the coupling release unit,
Pull out the analytical device from the containment chamber,
The opening of the storage chamber is closed in a state where the analysis cell is stored in the storage chamber.
　本発明のディスポーザル分析セルは、被分析部と第１被結合部と第２被結合部とを有し、
前記第１被結合部は、
　分析デバイスと結合可能な被結合部であり、
前記第２被結合部は、
　分析セル廃棄容器と結合可能な被結合部であり、
分析開始時、
　前記第１被結合部により、前記分析デバイスと結合し、
分析終了後、
　前記第２被結合部により、前記分析セル廃棄容器の結合部と結合し、
　前記分析セル廃棄容器の結合解除部により、前記第１被結合部における前記分析デバイスとの結合が解除されることを特徴とする。 The disposal analysis cell of the present invention has an analyzed part, a first coupled part, and a second coupled part,
The first coupled portion is
A coupled portion that can be coupled to an analytical device;
The second coupled portion is
It is a coupled part that can be coupled with the analysis cell waste container,
At the start of analysis,
The first coupled portion is coupled to the analysis device,
After the analysis
The second coupled part is coupled to the coupling part of the analysis cell disposal container,
The coupling with the analysis device in the first coupled part is released by the coupling releasing part of the analysis cell disposal container.
　本発明の分析セルのディスポーザルキットは、前記本発明の分析セル廃棄容器と、前記本発明の分析セルとを含むことを特徴とする。 The analysis cell disposal kit of the present invention includes the analysis cell waste container of the present invention and the analysis cell of the present invention.
　本発明の分析デバイスは、結合部と、分析部とを有し、前記結合部は、前記本発明の分析セルの第１被結合部と結合可能な結合部であり、前記分析部は、前記分析セルの被分析部を分析する分析部であり、前記結合部における前記分析セルとの結合が、前記本発明の分析セル廃棄容器または専用解除装置によって、解除可能であることを特徴とする。 The analysis device of the present invention includes a coupling unit and an analysis unit, and the coupling unit is a coupling unit that can be coupled to the first coupled unit of the analysis cell of the present invention. An analysis unit for analyzing an analysis target portion of the analysis cell, wherein the combination with the analysis cell in the combination unit can be released by the analysis cell disposal container or the dedicated release device of the present invention.
　本発明によれば、例えば、分析者が、分析終了後における分析セルに、直接触れることなく、また、前記分析セルが分析環境に露出することなく、前記分析セルを廃棄できる。このため、高い安全を確保することができる。 According to the present invention, for example, an analyst can discard the analysis cell without directly touching the analysis cell after completion of the analysis and without exposing the analysis cell to the analysis environment. For this reason, high safety can be ensured.
図１は、実施形態１における分析セルと分析デバイスの一例を示す斜視図である。FIG. 1 is a perspective view illustrating an example of an analysis cell and an analysis device according to the first embodiment. 図２は、実施形態１における分析セル廃棄容器と、その使用方法の概略を示す斜視図である。FIG. 2 is a perspective view showing an outline of an analysis cell waste container and a method for using the same in the first embodiment. 図３は、実施形態２における分析セル、分析デバイス、分析セル廃棄容器の一例の概略を示す平面図である。FIG. 3 is a plan view illustrating an outline of an example of an analysis cell, an analysis device, and an analysis cell waste container in the second embodiment. 図４は、実施形態２における分析セル廃棄容器の使用方法の概略を示す平面図である。FIG. 4 is a plan view schematically showing a method for using the analysis cell waste container in the second embodiment. 図５は、実施形態２における分析セル廃棄容器の使用方法の概略を示す平面図である。FIG. 5 is a plan view showing an outline of a method of using the analysis cell waste container in the second embodiment.
　本発明の分析セル廃棄容器は、例えば、前記結合部が、前記解除部を兼ねており、前記結合部により、前記分析セルと結合するとともに、前記分析セルと前記分析デバイスとの結合を解除する。 In the analysis cell disposal container of the present invention, for example, the coupling unit also serves as the releasing unit, and the coupling unit is coupled to the analysis cell, and the coupling between the analysis cell and the analysis device is released. .
　本発明の分析セル廃棄容器は、例えば、前記収容室が、袋状である。 In the analysis cell waste container of the present invention, for example, the storage chamber has a bag shape.
　本発明の分析セル廃棄容器は、例えば、前記収容室が、可撓性である。 In the analysis cell waste container of the present invention, for example, the storage chamber is flexible.
　本発明の分析セル廃棄容器は、例えば、前記収容室の開口部が、チャック部を有し、前記チャック部により開閉可能である。 In the analysis cell waste container of the present invention, for example, the opening of the storage chamber has a chuck portion, and can be opened and closed by the chuck portion.
　本発明の分析セル廃棄容器は、例えば、前記収容室が、前記開口部の他端に、把持部を有する。 In the analysis cell waste container of the present invention, for example, the storage chamber has a gripping portion at the other end of the opening.
　本発明の分析セル廃棄容器は、例えば、前記把持部が、ハンドル型である。 In the analysis cell disposal container of the present invention, for example, the grip portion is a handle type.
　以下、本発明について、例を挙げてさらに具体的に説明する。ただし、本発明は、以下の説明により限定されない。 Hereinafter, the present invention will be described more specifically with examples. However, the present invention is not limited by the following description.
［実施形態１］
　実施形態１は、図を用いて、分析セル廃棄容器の一例について説明する。 [Embodiment 1]
Embodiment 1 demonstrates an example of an analysis cell disposal container using a figure.
　図１の斜視図に、分析セルと分析デバイスとの概略を示す。図１（Ａ）に示すように、分析セル１０は、把持部１０１および分析基板１０２を有し、把持部１０１は、後述する分析セル廃棄容器に対する被結合部１０４を有し、分析基板１０２に、複数の反応部１０３を有する。複数の反応部１０３のそれぞれにおいて、例えば、一部または全体が、分析デバイスによって分析される被分析部である。また、図１（Ａ）に示すように、分析デバイス２０は、分析セル１０を収容する収容室２０１を有する。そして、使用時において、分析セル１０の反応部１０３に試料を添加すると、図１（Ｂ）に示すように、分析セル１０を、分析デバイス２０の収容室２０１に挿入し、図１（Ｃ）に示すように、分析セル１０の分析基板１０２を、分析デバイス２０の収容室２０１に収容し、反応を行う。 The outline of the analysis cell and the analysis device is shown in the perspective view of FIG. As shown in FIG. 1A, the analysis cell 10 has a gripping portion 101 and an analysis substrate 102. The gripping portion 101 has a portion 104 to be coupled to an analysis cell disposal container described later. And a plurality of reaction units 103. In each of the plurality of reaction units 103, for example, a part or all of the reaction units 103 are analyzed units analyzed by the analysis device. As shown in FIG. 1A, the analysis device 20 has a storage chamber 201 that stores the analysis cell 10. When the sample is added to the reaction unit 103 of the analysis cell 10 in use, the analysis cell 10 is inserted into the storage chamber 201 of the analysis device 20 as shown in FIG. As shown in FIG. 2, the analysis substrate 102 of the analysis cell 10 is accommodated in the accommodation chamber 201 of the analysis device 20 and reacted.
　図２の斜視図に、分析セル廃棄容器３０と、分析セル廃棄容器３０の使用の概略を示す。図２（Ａ）に示すように、分析セル廃棄容器３０は、収容室３０１を有する。収容室３０１は、一方が開口した袋状であり、開口部３０２側には、開閉可能なチャック部３０３を有する。収容室３０１は、分析デバイス２０に挿入された状態の分析セル１０を収容可能な収容空間を有している。収容室３０１は、開口部３０２とは反対側に、固定部３０６を有し、固定部３０６には、収容室３０１の外部に向かって把持部３０５が固定され、収容室３０１の内部に向かって、結合部３０４が固定されている。把持部３０５は、ハンドル型であり、分析セル廃棄容器３０の取扱いを容易にするための部位である。結合部３０４は、分析セル１０と結合可能な結合部と、分析セル１０と分析デバイス２０との結合を解除可能な解除部とを兼ねる。 FIG. 2 is a perspective view schematically showing the use of the analysis cell waste container 30 and the analysis cell waste container 30. As shown in FIG. 2A, the analysis cell waste container 30 has a storage chamber 301. The storage chamber 301 has a bag shape with one open, and has an openable / closable chuck portion 303 on the opening 302 side. The storage chamber 301 has a storage space in which the analysis cell 10 inserted in the analysis device 20 can be stored. The storage chamber 301 has a fixing portion 306 on the side opposite to the opening 302, and a holding portion 305 is fixed to the fixing portion 306 toward the outside of the storage chamber 301, and toward the inside of the storage chamber 301. The coupling portion 304 is fixed. The grip 305 is a handle type and is a part for facilitating the handling of the analysis cell waste container 30. The coupling unit 304 serves as a coupling unit that can be coupled to the analysis cell 10 and a release unit that can decouple the analysis cell 10 and the analysis device 20.
　つぎに、図２を用いて、分析セル廃棄容器３０の使用方法を説明する。図２（Ａ）および（Ｂ）に示すように、分析セル廃棄容器３０の開口部３０２から、分析デバイス２０に挿入された状態で分析セル１０を、収容室３０１に収容する。この際、分析セル廃棄容器３０の結合部３０４を、分析セル１０の被結合部１０４と結合させることで、分析セル廃棄容器３０と分析セル１０とを固定し、且つ、分析セル１０と分析デバイス２０との結合を解除する。分析セル廃棄容器３０の結合部３０４による、分析セル１０との結合、および、分析セル１０と分析デバイス２０との結合解除の機構は、特に制限されない。前記機構については、例示を後述する。 Next, a method of using the analysis cell waste container 30 will be described with reference to FIG. As shown in FIGS. 2A and 2B, the analysis cell 10 is accommodated in the accommodation chamber 301 while being inserted into the analysis device 20 from the opening 302 of the analysis cell disposal container 30. At this time, the analysis cell disposal container 30 and the analysis cell 10 are fixed by coupling the coupling portion 304 of the analysis cell disposal container 30 with the coupled portion 104 of the analysis cell 10, and the analysis cell 10 and the analysis device are fixed. 20 is released. The mechanism for coupling with the analysis cell 10 and the coupling release between the analysis cell 10 and the analysis device 20 by the coupling unit 304 of the analysis cell disposal container 30 is not particularly limited. An example of the mechanism will be described later.
　前述のように、結合部３０４によって、分析セル廃棄容器３０は分析セル１０と結合されており、分析セル１０と分析デバイス２０との結合は解除されている。そこで、図２（Ｃ）に示すように、分析セル廃棄容器３０の把持部３０５を、分析デバイス２０とは反対方向に引っ張ることにより、分析セル廃棄容器３０とこれに結合した分析セル１０を、分析デバイス２０から離す。これによって、図２（Ｃ）に示すように、分析セル廃棄容器３０の収容室３０１には、分析セル１０が収容されることになる。そして、図２（Ｄ）に示すように、分析セル廃棄容器３０のチャックを閉じる。これによって、分析セル１０は、外部に露出することなく、分析セル廃棄容器３０の収容室３０１に収容された状態で、廃棄することができる。これによって、例えば、分析後の増幅産物が系外に漏出することも防止できる。 As described above, the analysis cell disposal container 30 is coupled to the analysis cell 10 by the coupling unit 304, and the coupling between the analysis cell 10 and the analysis device 20 is released. Therefore, as shown in FIG. 2C, by pulling the grip portion 305 of the analysis cell waste container 30 in the direction opposite to the analysis device 20, the analysis cell waste container 30 and the analysis cell 10 coupled thereto are obtained. Separate from the analysis device 20. As a result, the analysis cell 10 is accommodated in the accommodation chamber 301 of the analysis cell disposal container 30 as shown in FIG. Then, as shown in FIG. 2D, the chuck of the analysis cell waste container 30 is closed. As a result, the analysis cell 10 can be discarded while being stored in the storage chamber 301 of the analysis cell disposal container 30 without being exposed to the outside. Thereby, for example, the amplified product after analysis can be prevented from leaking out of the system.
　分析セル廃棄容器３０は、収容室３０１の内部に、分析デバイス２０と結合した状態で分析セル１０を収容し、また、分析セル１０から分析デバイス２０を離した後、開口部３０２をチャック部３０３により閉じる必要がある。このため、例えば、取扱い性に優れることから、収容室３０１は、例えば、可撓性材料から形成されていることが好ましい。前記可撓性材料は、例えば、ポリエチレン、ポリプロピレン、ポリテトラフルオロエチレン、ポリブチレンテレフタレート等のポリオレフィン；軟質ポリ塩化ビニル等のポリ塩化ビニル；ポリビニルアルコール；エチレン－酢酸ビニル共重合樹脂；シリコン;ポリウレタン；ナイロン等の樹脂があげられる。収容室３０１は、例えば、内部が確認可能なように、透明部材または半透明部材が好ましい。 The analysis cell disposal container 30 accommodates the analysis cell 10 in a state of being coupled to the analysis device 20 in the storage chamber 301, and after separating the analysis device 20 from the analysis cell 10, the opening 302 is formed in the chuck portion 303. Need to close. For this reason, for example, since the handleability is excellent, the storage chamber 301 is preferably formed of, for example, a flexible material. Examples of the flexible material include polyolefins such as polyethylene, polypropylene, polytetrafluoroethylene, and polybutylene terephthalate; polyvinyl chloride such as soft polyvinyl chloride; polyvinyl alcohol; ethylene-vinyl acetate copolymer resin; silicon; Examples thereof include resins such as nylon. The storage chamber 301 is preferably a transparent member or a translucent member so that the inside can be confirmed, for example.
　分析セル廃棄容器３０の開口部３０２は、開閉可能であればよく、開閉は、例えば、前述のようなチャック部３０３により行われる、チャック部３０３による開閉は、例えば、スライド式があげられる。 The opening 302 of the analysis cell disposal container 30 only needs to be openable and closable. For example, the opening and closing is performed by the chuck portion 303 as described above. The opening and closing by the chuck portion 303 is, for example, a slide type.
　本発明において、分析セル１０の種類は、特に制限されず、例えば、核酸増幅の反応系、抗原抗体反応系等に使用するセルがあげられる。 In the present invention, the type of the analysis cell 10 is not particularly limited, and examples thereof include cells used for nucleic acid amplification reaction systems, antigen-antibody reaction systems, and the like.
［実施形態２］
　実施形態２は、図を用いて、分析デバイスへの分析セルの結合、分析セルへの分析セル廃棄容器との結合、および分析デバイスからの分析セルの結合解除の機構の一例について説明する。 [Embodiment 2]
Embodiment 2 demonstrates an example of the mechanism of the coupling | bonding of the analysis cell to an analysis device, the coupling | bonding with the analysis cell waste container to an analysis cell, and the decoupling | bonding of the analysis cell from an analysis device using a figure.
　図３から図４は、分析セル、分析デバイス、および分析セル廃棄容器の間における結合と結合解除の機構を示す概略図である。図３は、分析セル、分析デバイスおよび分析セル廃棄容器の概略を示す平面図である。図３および図４は、前記機構の概略の説明を目的とすることから、その他の構成については省略する。 3 to 4 are schematic views showing a coupling and decoupling mechanism between the analysis cell, the analysis device, and the analysis cell waste container. FIG. 3 is a plan view schematically showing an analysis cell, an analysis device, and an analysis cell waste container. 3 and 4 are for the purpose of explaining the outline of the mechanism, and the other configurations are omitted.
　図３（Ａ）は、分析セル１０の平面図であり、分析デバイス２０への結合方向に対する垂直方向の両端に、分析デバイス２０および分析セル廃棄容器３０と結合するための一対の被結合部１０４を有し、被結合部１０４は、凹状である。つぎに、図３（Ｂ）は、分析デバイス２０の平面図であり、分析セル１０との結合方向に対する垂直方向の両端に、分析セル１０と結合するための一対の結合部２０４を有する。一対の結合部２０４は、一端に、内部方向に対する引掛け部２０４ａを有し、他端に固定された支点２０４ｂを有する。そして、結合部２０４は、引掛け部２０４ａ側において、分析デバイス２０に固定された圧縮スプリング２０５と連結されている。つぎに、図３（Ｃ）は、分析セル廃棄容器３０の平面図であり、分析セル１０への結合方向に対する垂直方向の両端に、分析セル１０と結合し、且つ、分析セル１０と分析デバイス２０との結合を解除するための一対の結合部３０４を有する。一対の結合部３０４は、一端に、内部方向に対する引掛け部３０４ａを有する。 FIG. 3A is a plan view of the analysis cell 10, and a pair of coupled portions 104 for coupling to the analysis device 20 and the analysis cell waste container 30 at both ends in the direction perpendicular to the coupling direction to the analysis device 20. The coupled portion 104 is concave. Next, FIG. 3B is a plan view of the analysis device 20, and has a pair of coupling portions 204 for coupling with the analysis cell 10 at both ends in the direction perpendicular to the coupling direction with the analysis cell 10. The pair of coupling portions 204 has a hook portion 204a with respect to the inner direction at one end and a fulcrum 204b fixed at the other end. The coupling portion 204 is connected to a compression spring 205 fixed to the analysis device 20 on the hooking portion 204a side. Next, FIG. 3C is a plan view of the analysis cell waste container 30, which is coupled to the analysis cell 10 at both ends in the direction perpendicular to the coupling direction to the analysis cell 10, and the analysis cell 10 and the analysis device. 20 has a pair of coupling portions 304 for releasing the coupling with the unit 20. The pair of coupling portions 304 has a hooking portion 304a for the inner direction at one end.
　まず、分析セル１０を分析デバイス２０に結合させる。図４（Ａ）および（Ｂ）に示すように、矢印方向に向かって、分析セル１０を分析デバイス２０に挿入する。分析セル１０が分析デバイス２０に完全に挿入されると、分析セル１０の凹状の被結合部１０４に、分析デバイス２０の結合部２０４の引掛け部２０４ａが引っ掛かり、分析セル１０が分析デバイス２０に固定される。 First, the analysis cell 10 is coupled to the analysis device 20. As shown in FIGS. 4A and 4B, the analysis cell 10 is inserted into the analysis device 20 in the direction of the arrow. When the analysis cell 10 is completely inserted into the analysis device 20, the hook portion 204 a of the coupling portion 204 of the analysis device 20 is hooked on the concave coupled portion 104 of the analysis cell 10, and the analysis cell 10 is attached to the analysis device 20. Fixed.
　つぎに、図４（Ｃ）に示す分析デバイス２０に固定化された分析セル１０に対して、分析セル廃棄容器３０を準備し、図５（Ａ）に示すように、矢印方向に向かって、分析セル廃棄容器３０を、分析デバイス２０内に固定化された分析セル１０に被せていく。すると、図５（Ｂ）に示すように、分析セル廃棄容器３０の結合部３０４の先端が、分析デバイス２０における結合部２０４の引掛け部２０４ａの先端に当たり、分析セル１０の凹状の被結合部１０４と、分析デバイス２０の引掛け部２０４ａとの引っ掛かりを解除する。そして、分析セル廃棄容器３０における結合部３０４の引掛け部３０４ａが、分析セル１０の凹状の被結合部１０４に引っ掛かり、分析セル１０は、分析デバイス２０との結合が解除され、分析セル廃棄容器３０に固定される。そして、図５（Ｃ）に示すように、分析デバイス２０を把持し、且つ、矢印方向に向かって、分析セル廃棄容器３０を引っ張ることで、分析デバイス２０から、分析セル廃棄容器３０に固定化された分析セル１０を引き抜くことができる。引き抜かれた分析セル１０は、分析セル廃棄容器３０の収容室３０１内に収容されているため、前述のように、開口部３０２を閉じることで、外部に露出することなく、廃棄できる。 Next, an analysis cell waste container 30 is prepared for the analysis cell 10 fixed to the analysis device 20 shown in FIG. 4C, and as shown in FIG. The analysis cell waste container 30 is put on the analysis cell 10 fixed in the analysis device 20. Then, as shown in FIG. 5B, the tip of the coupling portion 304 of the analysis cell disposal container 30 hits the tip of the hook portion 204a of the coupling portion 204 in the analysis device 20, and the concave coupled portion of the analysis cell 10 is obtained. 104 and the hooking part 204a of the analysis device 20 are released. Then, the hooking portion 304a of the coupling portion 304 in the analysis cell disposal container 30 is hooked on the concave coupled portion 104 of the analysis cell 10, and the analysis cell 10 is released from the coupling with the analysis device 20, and the analysis cell disposal container 30 is fixed. Then, as shown in FIG. 5 (C), the analysis device 20 is gripped and the analysis cell waste container 30 is pulled in the direction of the arrow, so that the analysis device 20 is fixed to the analysis cell waste container 30. The analyzed analysis cell 10 can be pulled out. Since the extracted analysis cell 10 is stored in the storage chamber 301 of the analysis cell disposal container 30, it can be discarded without being exposed to the outside by closing the opening 302 as described above.
　なお、分析デバイス２０と分析セル１０との結合の解除は、これらの実施形態には制限されず、例えば、専用のロック解除装置によって、解除してもよい。この場合、前記ロック解除装置は、例えば、分析セル廃棄容器３０の結合部３０４の先端と同様に、分析デバイス２０における結合部２０４の引掛け部２０４ａの先端に当たり、分析セル１０の凹状の被結合部１０４と、分析デバイス２０の引掛け部２０４ａとの引っ掛かりを解除するような部位を有してもよい。 Note that the release of the connection between the analysis device 20 and the analysis cell 10 is not limited to these embodiments, and may be released by, for example, a dedicated lock release device. In this case, for example, the unlocking device hits the tip of the hooking portion 204a of the coupling portion 204 in the analysis device 20 in the same manner as the tip of the coupling portion 304 of the analysis cell disposal container 30, and the concave coupled portion of the analysis cell 10 is connected. The part 104 and the hooking part 204a of the analysis device 20 may have a part that releases the hook.
　本発明によれば、例えば、分析者が、分析終了後における分析セルに直接触れることなく、また、前記分析セルが分析環境に露出することなく、前記分析セルを廃棄できる。このため、高い安全を確保することができる。 According to the present invention, for example, an analyzer can discard the analysis cell without directly touching the analysis cell after completion of the analysis and without exposing the analysis cell to the analysis environment. For this reason, high safety can be ensured.
　この出願は、２０１７年１月２５日に出願された日本出願特願２０１７－０１１６８２を基礎とする優先権を主張し、その開示の全てをここに取り込む。 This application claims priority based on Japanese Patent Application No. 2017-011682 filed on January 25, 2017, the entire disclosure of which is incorporated herein.
１０　　分析セル
２０　　分析デバイス
３０　　分析セル廃棄容器
１０１　把持部
１０２　分析基板
１０３　反応部
１０４　被結合部
２０４、３０４　結合部
２０１　収容室
２０５　圧縮スプリング
３０１　収容室
３０２　開口部
３０３　チャック部
３０５　把持部
３０６　固定部 DESCRIPTION OF SYMBOLS 10 Analysis cell 20 Analysis device 30 Analysis cell disposal container 101 Grip part 102 Analysis board 103 Reaction part 104 To-be-joined part 204,304 Coupling part 201 Accommodating chamber 205 Compression spring 301 Accommodating chamber 302 Opening part 303 Chuck part 305 Grasping part 306 Fixing part

Claims (10)

  1. 収容室と結合部と結合解除部とを有し、
    前記収容室は、
    　分析セルの収容空間を有し、
    　開閉可能な開口部を有し、
    前記結合部は、
    　分析セルと結合可能な結合部であり、
    前記結合解除部は、
    　前記分析セルと分析デバイスとの結合を解除可能な解除部であり、
    使用時、
    　前記収容室の開口部を開口した状態で、前記収容室の内部に、前記分析デバイスに挿入された状態の前記分析セルを収容し、
    　前記結合部により、前記分析セルと結合し、
    　前記結合解除部により、前記分析セルと前記分析デバイスとの結合を解除し、
    前記収容室から、前記分析デバイスを引き抜き、
    　前記収容室に前記分析セルが収容された状態で、前記収容室の前記開口部を閉じることを特徴とする分析セル廃棄容器。     A storage chamber, a coupling portion and a coupling release portion;
    The containment chamber is
    Having a storage space for the analysis cell;
    Has an openable and closable opening,
    The coupling portion is
    It is a coupling part that can be coupled with the analysis cell,
    The uncoupling part is
    A release unit capable of releasing the coupling between the analysis cell and the analysis device;
    while using it,
    In the state where the opening of the storage chamber is opened, the analysis cell in a state inserted into the analysis device is stored inside the storage chamber,
    Combined with the analysis cell by the combining unit,
    Release the coupling between the analysis cell and the analysis device by the coupling release unit,
    Pull out the analytical device from the containment chamber,
    An analysis cell disposal container, wherein the opening of the storage chamber is closed in a state where the analysis cell is stored in the storage chamber.
  2. 前記結合部が、前記解除部を兼ねており、
    前記結合部により、前記分析セルと結合するとともに、前記分析セルと前記分析デバイスとの結合を解除する、請求項１記載の分析セル廃棄容器。     The coupling portion also serves as the releasing portion;
    The analysis cell waste container according to claim 1, wherein the analysis unit is connected to the analysis cell and the analysis cell and the analysis device are disconnected by the combination unit.
  3. 前記収容室が、袋状である、請求項１または２記載の分析セル廃棄容器。 The analysis cell disposal container according to claim 1 or 2, wherein the storage chamber has a bag shape.
  4. 前記収容室が、可撓性である、請求項１から３のいずれか一項に記載の分析セル廃棄容器。 The analysis cell disposal container according to any one of claims 1 to 3, wherein the storage chamber is flexible.
  5. 前記収容室の開口部が、チャック部を有し、前記チャック部により開閉可能である、請求項１から４のいずれか一項に記載の分析セル廃棄容器。 The analysis cell waste container according to any one of claims 1 to 4, wherein the opening of the storage chamber has a chuck portion and can be opened and closed by the chuck portion.
  6. 前記収容室が、前記開口部の他端に、把持部を有する、請求項１から５のいずれか一項に記載の分析セル廃棄容器。 The analysis cell waste container according to any one of claims 1 to 5, wherein the storage chamber has a grip portion at the other end of the opening.
  7. 前記把持部が、ハンドル型である、請求項６記載の分析セル廃棄容器。 The analysis cell disposal container according to claim 6, wherein the grip portion is a handle type.
  8. 被分析部と第１被結合部と第２被結合部とを有し、
    前記第１被結合部は、
    　分析デバイスと結合可能な被結合部であり、
    前記第２被結合部は、
    　分析セル廃棄容器と結合可能な被結合部であり、
    分析開始時、
    　前記第１被結合部により、前記分析デバイスと結合し、
    分析終了後、
    　前記第２被結合部により、前記分析セル廃棄容器の結合部と結合し、
    　前記分析セル廃棄容器の結合解除部により、前記第１被結合部における前記分析デバイスとの結合が解除されることを特徴とするディスポーザル分析セル。     Having an analyzed part, a first coupled part, and a second coupled part;
    The first coupled portion is
    A coupled portion that can be coupled to an analytical device;
    The second coupled portion is
    It is a coupled part that can be coupled with the analysis cell waste container,
    At the start of analysis,
    The first coupled portion is coupled to the analysis device,
    After the analysis
    The second coupled part is coupled to the coupling part of the analysis cell disposal container,
    The disposal analysis cell according to claim 1, wherein the analysis cell disposal container is released from the connection release unit to release the connection with the analysis device in the first connected portion.
  9. 請求項１から７のいずれか一項に記載の分析セル廃棄容器と、請求項８記載の分析セルとを含むことを特徴とする分析セルのディスポーザルキット。 An analysis cell disposal kit comprising the analysis cell waste container according to any one of claims 1 to 7 and the analysis cell according to claim 8.
  10. 結合部と、分析部とを有し、
    前記結合部は、請求項８記載の分析セルの第１被結合部と結合可能な結合部であり、
    前記分析部は、前記分析セルの被分析部を分析する分析部であり、
    前記結合部における前記分析セルとの結合が、請求項１から７のいずれか一項に記載の分析セル廃棄容器または専用解除装置によって、解除可能であることを特徴とする分析デバイス。     A coupling unit and an analysis unit;
    The coupling part is a coupling part that can be coupled to the first coupled part of the analysis cell according to claim 8,
    The analysis unit is an analysis unit that analyzes a portion to be analyzed of the analysis cell,
    The analysis device characterized in that the connection with the analysis cell in the connection part can be released by the analysis cell disposal container or the dedicated release device according to any one of claims 1 to 7.
PCT/JP2017/045014 2017-01-25 2017-12-15 Analysis-cell disposal container, disposable analysis cell, and analysis-cell disposable kit WO2018139099A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009042227A (en) * 2007-08-02 2009-02-26 F Hoffmann-La Roche Ag Forwarding device of testing element
WO2013038691A1 (en) * 2011-09-14 2013-03-21 パナソニック株式会社 Biological information detection sensor supply device
WO2013042536A1 (en) * 2011-09-20 2013-03-28 テルモ株式会社 Component measuring device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009042227A (en) * 2007-08-02 2009-02-26 F Hoffmann-La Roche Ag Forwarding device of testing element
WO2013038691A1 (en) * 2011-09-14 2013-03-21 パナソニック株式会社 Biological information detection sensor supply device
WO2013042536A1 (en) * 2011-09-20 2013-03-28 テルモ株式会社 Component measuring device

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