WO2018135733A1 - Health food containing sumac extract for tuberculosis prevention and manufacturing method therefor - Google Patents

Health food containing sumac extract for tuberculosis prevention and manufacturing method therefor Download PDF

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Publication number
WO2018135733A1
WO2018135733A1 PCT/KR2017/012631 KR2017012631W WO2018135733A1 WO 2018135733 A1 WO2018135733 A1 WO 2018135733A1 KR 2017012631 W KR2017012631 W KR 2017012631W WO 2018135733 A1 WO2018135733 A1 WO 2018135733A1
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Prior art keywords
tuberculosis
extract
prevention
health food
sumac
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PCT/KR2017/012631
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French (fr)
Korean (ko)
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김화원
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김화원
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B29/00—Packaging of materials presenting special problems
    • B65B29/02—Packaging of substances, e.g. tea, which are intended to be infused in the package
    • B65B29/028—Packaging of substances, e.g. tea, which are intended to be infused in the package packaging infusion material into filter bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/70—Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for
    • B65D85/804—Disposable containers or packages with contents which are mixed, infused or dissolved in situ, i.e. without having been previously removed from the package
    • B65D85/808—Disposable containers or packages with contents which are mixed, infused or dissolved in situ, i.e. without having been previously removed from the package for immersion in the liquid to release part or all of their contents, e.g. tea bags
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/314—Foods, ingredients or supplements having a functional effect on health having an effect on lung or respiratory system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00—Processes
    • A23V2300/14—Extraction
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00—Processes
    • A23V2300/24—Heat, thermal treatment

Definitions

  • the present invention relates to a tuberculosis preventive health food and a method for manufacturing the same, and more particularly, to a tuberculosis preventive health food containing a sumac extract and a method for manufacturing the same.
  • Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is characterized by slow progression or maintenance in the long term compared to other infectious diseases. It spreads through the air and starts infection through the lungs. , Brain, larynx, bones, gastrointestinal tract, peritoneum, kidneys, etc.) to cause tuberculosis of each organ. Most people with tuberculosis bacillus are asymptomatic, and only a few of them develop tuberculosis, and according to the World Health Organization (WHO), 8 million people around the world get active tuberculosis every year and about 2 million people die. .
  • WHO World Health Organization
  • the incidence of active tuberculosis is 0.91%, and smears of tuberculosis bacteria from sputum (sputum, etc. of the patient's sputum are smeared and stained under a microscope). The incidence of tuberculosis bacteria is observed.) The incidence of tuberculosis is about half of this number, 0.41%.
  • This high rate in Korea is three times that of 0.33% of tuberculosis in Japan and 0.15% of smear-positive tuberculosis, which means that TB is still a serious health problem in Korea.
  • tuberculosis is a disease that can be prevented.
  • Prevention of tuberculosis can be divided into primary prevention, which is started before infection, and secondary prevention, which prevents tuberculosis from progressing to active tuberculosis.
  • secondary prevention prevents tuberculosis from progressing to active tuberculosis.
  • a second preventive method is the use of prophylactic drugs, which are used to detect people with tuberculosis at an early stage and prevent the early detection of people from developing tuberculosis.
  • isoniazid a method called isoniazid (INH) is administered to people infected with Mycobacterium tuberculosis but not yet developed into active tuberculosis, thereby preventing the development of active tuberculosis by eradicating the existing tuberculosis bacteria.
  • the drug which is administered as a secondary preventive measure for tuberculosis, is taken daily for six to nine months, and some side effects should be noted.
  • a typical side effect of the drug is hepatitis, which occurs in some people who take the drug, especially in people over 35 years of age. Because of these side effects, some countries over 35 years of age are advised to take anti-tuberculosis drugs when they are active without developing isoniazide.
  • Tuberculosis incidence in each country is very low (0.05%), and it is recommended to prevent it by this method. In Korea, tuberculosis incidence is 0.91%, which is about 60 times that number, much more than in the United States.
  • tuberculosis As a rule of treatment for tuberculosis currently used, four drugs are used in combination to prevent hospitalization and to acquire resistance.
  • the biggest problem of tuberculosis treatment is a special treatment method when resistance to primary anti-tuberculosis drugs occurs.
  • MDR-TB multidrug-resistant tuberculosis
  • Tuberculosis is on the rise again due to the occurrence of AIDS and the prevalence of AIDS. Therefore, there is a need for the development of prophylactic and therapeutic agents having new ingredients other than the existing drugs.
  • the existing tuberculosis treatment agent the resistance to the drug is used repeatedly in most cases, tuberculosis prevention and treatment prepared by using the traditional Chinese medicine method using a method of mixing a variety of medicinal plants, Since there is a problem that most of them use only a method of arranging a large number of plants, there is a need to develop a tuberculosis prevention and treatment with new ingredients that can overcome these problems.
  • the present invention has been proposed to solve the above problems of the conventionally proposed methods, and unlike conventional medicines for the prevention and treatment of tuberculosis, which uses existing expensive materials and undergoes several steps of manufacturing,
  • An object thereof is to provide a health food and a method of manufacturing the same.
  • the present invention by providing a tuberculosis preventive active ingredient containing lacquer extract to the general user easily in the form of tea bags or beverages, as the intake rate of the general user to take the tuberculosis preventive active ingredient is increased, Another object of the present invention is to provide a tuberculosis preventive health food containing a sumac extract and a method for producing the same, which may help prevent tuberculosis.
  • the present invention can be usefully used as a novel tuberculosis prevention and treatment without resistance, in the absence of a suitable therapeutic drug for multidrug-resistant tuberculosis due to the resistance of the drug for the prevention and treatment of tuberculosis, It is another object of the present invention to provide a health food for preventing tuberculosis containing the sumac extract and a method of manufacturing the same.
  • Including the sumac extract as an active ingredient is characterized by its configuration.
  • the sumac extract is the sumac extract
  • the sumac extract is the sumac extract
  • the sumac extract is the sumac extract
  • It may be packaged in a tea bag or included in a beverage.
  • step (2) from the lacquer prepared in step (1), comprising extracting the extract of the lacquer using a solvent of 2 to 40 times the total weight by weight, the lacquer extract is extracted by heating to 60 ⁇ 70 °C It is characterized by the configuration thereof.
  • the sumac extract is the sumac extract
  • It may be packaged in a tea bag or included in a beverage.
  • tuberculosis preventive active ingredient containing the sumac extract so that the general user can easily in the form of tea bags or beverages, as the intake rate of the general user to take the tuberculosis preventive active ingredient increases It can help prevent tuberculosis.
  • 1 is a view showing the development of tuberculosis patients in Korea year by year.
  • FIG. 2 is a view showing an example of the lacquer tree used in the tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention.
  • Figure 3 is a view showing the flow of a method for producing a tuberculosis prevention health food containing a sumac extract according to an embodiment of the present invention.
  • active ingredient includes a substance or a group of substances (a pharmacologically active ingredient or the like which is expected to express the efficacy effect of the composition directly or indirectly by intrinsic pharmacological action). Means a main component).
  • FIG. 1 is a view showing the development of tuberculosis patients in Korea by year. As shown in FIG. 1, the incidence of tuberculosis patients by year showed a tendency to decrease gradually until 2003, but has been increasing again since 2004, from which the necessity of tuberculosis prevention can be confirmed.
  • Lacquer is a deciduous arboreous tree of China, which is a deciduous arborescent of the Lacaceae family, is 7 ⁇ 10m high, and is an idol of the leaf composed of 7 ⁇ 11 small leaves. The fruit ripens to yellow in October with the nucleus.
  • Figure 2 is a view showing an example of the lacquer tree used in the tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention. As shown in FIG. 2, the bark and young leaves of the lacquer tree are used for medicinal or edible use. Specifically, the extract extracted from the bark of the lacquer tree is called lacquer and the extracted lacquer is used for medicinal purposes. I'm doing it.
  • lacquer In oriental medicine, the effect of lacquer is known to be effective in promoting blood circulation, hookworm, abdominal pain, excessive stomach acid, cough, pulmonary tuberculosis, pain, constipation, diabetes, malaria, anti-inflammatory, arthritis, antiseptic, dry stomach, and anti-cancer.
  • lacquer removes tuberculosis bacteria from the lungs, acts as a blood donor in the liver and a blue blood agent in the heart, and is also effective in neuralgia, arthritis and skin diseases.
  • Representative components of the extract extracted from the lacquer tree having such efficacy are known as urushiol and flavonoid strain and phenolic compound strain.
  • urushiol a component of the lacquer extract
  • Various flavonoids which are abundant in the wood part of the lacquer tree, are used to suppress cancer cells by the neovascularization effect. It works by killing, protecting blood vessels and capillaries, inhibiting lipid peroxide, and inhibiting allergies and skin diseases.
  • flavonoids have been shown to protect the liver, and 2 ml of lacquer flavonoids were administered to rats at a concentration of 500 mg / ml, resulting in a blood alcohol concentration of 0.162% to 0.014 in rats treated with 40% alcohol. From the decrease in%, the effect of liver protection by flavonoids can be confirmed.
  • urushiol acts as a potent cytotoxic substance for cancer cells, but at the same time it is also a potent allergen, and therefore must be used in consideration of the intake of the urushiol component.
  • the lacquer tree has a variety of effects, but because there is a toxic component called urushiol, the intake was not large.
  • extraction methods are known.
  • the lacquer in order to extract the lacquer extract, the lacquer is thoroughly washed with water, dried and the dried lacquer is put into the extraction container, and the total of the lacquer Extract can be extracted using a solvent of 2 to 40 times the weight by weight.
  • Such extraction may be performed after the temperature rises, or may be performed after a certain period of time. More specifically, the temperature to be heated for extraction can be heated to 60 ⁇ 70 °C, depending on the embodiment it is preferable to heat at 64 °C.
  • the solvent used for extracting the lacquer extract may be extracted using water, in particular, purified water as a solvent, ethanol, methanol and Other solvents can also be used, and by using a method of lowering the water ratio and increasing the solvent ratio in the ratio of the extraction solvent, the yield can be reduced but the effect of the drug can be increased.
  • the lacquer extract of tuberculosis preventive health food containing the lacquer extract according to an embodiment of the present invention may be packaged in a tea bag or included in a beverage.
  • the usability of the extract can be increased, but the tea bag can be used a nonwoven fabric or the like that is commonly used, and the size of the tea bag is not limited, and may be packaged in different capacities of 5 to 100 g as necessary. .
  • the form containing the sumac extract is not limited to tea bags and beverages, and according to another embodiment, oral formulations such as granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, and sterilization It may be formulated in the form of an injection solution.
  • the health food including the lacquer extract of the present invention is not particularly limited to other ingredients except for containing the indicated ratios as essential ingredients, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. have.
  • the health food of the present invention is a variety of nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, such as flavoring agents, coloring and neutralizing agents, pectic acid and salts thereof, ph regulators, stabilizers, preservatives, Glycerol, alcohols, carbonation agents used in carbonated drinks, and the like.
  • the present invention may contain a flesh for preparing natural fruit juices and fruit juice beverages and vegetable beverages, and various components may be used independently or in combination.
  • Figure 3 is a view showing the flow of a method for producing a tuberculosis prevention health food containing a sumac extract according to an embodiment of the present invention.
  • the method for producing a tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention preparing the lacquer (S10), and the sumac prepared in step S10 compared to the total weight Extracting the extract of the lacquer using the solvent of 2 to 40 times the weight (S20), the extract of the lacquer is characterized by its configuration that is extracted by heating to 60 ⁇ 70 °C.
  • the sumac extract extracted in step S20 may be provided in a form packed in a tea bag or included in a beverage.
  • tuberculosis preventive health foods containing the lacquer extract according to an embodiment of the present invention prepared by the manufacturing method as described above may be individually packaged in a single dose or packaged in a container.
  • the prepared lacquer is thoroughly washed with water and dried, and the dried lacquer is put into the extraction container.
  • the extract can be extracted using a solvent of 2 to 40 times the total weight of the sumac put, and water, in particular purified water is used as the solvent used for extraction. Extraction is performed for a predetermined time after the temperature of the solvent is warmed to 60-70 ° C., more specifically, when the temperature of the solvent reaches 64 ° C., the extract is obtained, and the extract thus obtained is packaged in a tea bag or a beverage. It can manufacture by including in the.
  • test subjects were given the health food prepared in Example 1 twice a day in the morning and evening. After 12 weeks of administration, the degree of tuberculosis prevention and improvement of the subjects was checked through a questionnaire to determine the effect of tuberculosis prevention and improvement.
  • Table 1 shows the results of the TB prevention and improvement effect after taking the tuberculosis preventive health food containing the lacquer extract proposed in the present invention.
  • Example 1 of the present invention As shown in Table 1, the test subjects taking the health food prepared according to Example 1 of the present invention had an improvement effect of 25% after one month, 50% after two months, and 65% after three months. It was found that the health food for preventing tuberculosis containing the lacquer extract proposed by the present invention was effective in preventing and improving tuberculosis symptoms.
  • Toxicity experiments were carried out using a central laboratory animal (ICR mouse), and 10 rats of each group were orally administered with the lacquer extract of the present invention at a dose of 5 g / kg / 10ml, and there were no animal deaths, clinical symptoms, and Hematological examination was performed by monitoring the weight change.
  • 10 oral doses were repeatedly administered at a dose of 2 g / kg / 10 ml, and as a result, no specific changes or toxicity changes were observed in all animals, even in blood tests and weight changes.
  • the sumac extract did not show toxicity change up to 5000g / kg, and the minimum lethal dose for oral administration was determined to be more than 5000g / kg.
  • the lacquer extract did not cause lethal individuals in the acute toxicity test and the repeated administration test, and no side effects were observed by the naked eye, and thus the toxicity was not expressed by oral administration of the lacquer extract.

Abstract

According to a health food containing a sumac extract for tuberculosis prevention and a manufacturing method therefor, which are proposed in the present invention, the health food is manufactured by a simple manufacturing process using materials capable of being easily obtained by an ordinary user in daily life, leading to low costs, unlike existing medicinal materials for the prevention and treatment of tuberculosis, which are obtained by several manufacturing process steps using high-priced materials. Therefore, the present invention can contribute greatly to the prevention of tuberculosis even in third, developing countries with high patient mortality rates.

Description

옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법Tuberculosis prevention health food containing sumac extract and its manufacturing method
본 발명은 결핵 예방용 건강식품 및 그 제조방법에 관한 것으로서, 보다 구체적으로는 옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법에 관한 것이다.The present invention relates to a tuberculosis preventive health food and a method for manufacturing the same, and more particularly, to a tuberculosis preventive health food containing a sumac extract and a method for manufacturing the same.
결핵이란 결핵균에 의해 발생하는 감염성 질환으로, 다른 감염성 질환에 비해 장기적으로 천천히 진행되거나 유지되는 특징이 있으며, 공기로 퍼져나가며 폐를 통하여 감염이 시작되고 폐를 제외한 우리 몸의 여러 장기(예를 들어, 뇌, 후두, 뼈, 위장관, 복막, 콩팥) 등을 침범하여 각 기관의 결핵을 유발한다. 대부분의 결핵균 감염자들은 증상이 없으며, 이들 중 일부분의 사람들에서만 결핵이 발생되고, 국제보건기구(WHO)에 의하면 전 세계에서 매년 8백만 명이 활동성 결핵에 걸리며, 약 2백만 명이 사망하는 것으로 보고되고 있다.Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is characterized by slow progression or maintenance in the long term compared to other infectious diseases. It spreads through the air and starts infection through the lungs. , Brain, larynx, bones, gastrointestinal tract, peritoneum, kidneys, etc.) to cause tuberculosis of each organ. Most people with tuberculosis bacillus are asymptomatic, and only a few of them develop tuberculosis, and according to the World Health Organization (WHO), 8 million people around the world get active tuberculosis every year and about 2 million people die. .
우리나라의 통계를 보면, 다른 사람에게 전염을 시킬 수 있는 질병상태인 활동성 결핵의 발생률은 0.91%이며, 가래에서 결핵균이 나오는 도말양성(환자의 가래 등을 유리슬라이드에 도말한 후 염색하여 현미경으로 관찰하였을 때 결핵균이 관찰되는 상태) 결핵발생률은 이 숫자의 약 절반인 0.41%에 이르고 있다. 우리나라의 이러한 높은 비율은, 일본의 결핵 발생률 0.33%와 도말양성 결핵 발생률 0.15%의 약 3배에 달하는 수치로, 이는 아직까지 우리나라에서 결핵이 심각한 보건학적 문제가 됨을 의미한다. 또한, 도 1에 도시된 바와 같이, 연도별 결핵 신(新)환자 발생추이는 인구 100,000명당 결핵신환자율은 2001년 72.1명, 2002년 67.2명, 2003년 64.0명으로 점차 줄어드는 경향을 보이다가, 2004년에 65.4명, 2005년에 73.0명으로 다시 늘어나서 2006년 73.2명, 2007년 71.6명, 2008년 70.3명. 2009년 73.5명으로 최근에는 다시 비슷한 발생추이임을 확인할 수 있다.According to the statistics of Korea, the incidence of active tuberculosis, a disease state that can infect other people, is 0.91%, and smears of tuberculosis bacteria from sputum (sputum, etc. of the patient's sputum are smeared and stained under a microscope). The incidence of tuberculosis bacteria is observed.) The incidence of tuberculosis is about half of this number, 0.41%. This high rate in Korea is three times that of 0.33% of tuberculosis in Japan and 0.15% of smear-positive tuberculosis, which means that TB is still a serious health problem in Korea. In addition, as shown in Figure 1, the trend of tuberculosis new patient outbreak by year tends to decrease gradually to 72.1 in 2001, 67.2 in 2002, 64.0 in 2003, The number increased to 65.4 in 2004, 73.0 in 2005, 73.2 in 2006, 71.6 in 2007, and 70.3 in 2008. As of 2009, 73.5 people are able to confirm similar trends.
다만, 이러한 결핵은 예방이 가능한 질병으로서, 결핵의 예방은 감염이 발생하기 전에 시작되는 1차 예방과 결핵균에 감염이 된 후 활동성 결핵으로 진행하는 것을 막는 2차 예방으로 나눌 수 있다. 공기를 통한 전염이 가능한 결핵균의 특성을 감안하였을 때, 1차 예방법으로는 적절한 공기순환(환기)을 하는 것이, 지역사회로의 결핵의 전염을 예방하는데 있어서 가장 중요하며, 결핵환자가 많이 드나드는 병원과 의원에서는, 결핵의 전염을 막기 위한 적절한 예방대책을 시행하여야 한다. 2차 예방법으로는 예방 약제를 사용하는 방법이 있으며, 이는 결핵에 감염된 사람을 조기에 발견하고, 조기에 발견된 사람들이 활동성 결핵으로 발전하는 것을 막는 것이다. 일예로, 결핵균에 감염되었으나 아직 활동성 결핵으로 발전하지는 않은 사람들에게 아이소나이아지드(isoniazid: INH)라는 약물을 투여하여, 기존의 결핵균을 박멸함으로써 활동성 결핵으로 발전하는 것을 막는 방법이 있다.However, such tuberculosis is a disease that can be prevented. Prevention of tuberculosis can be divided into primary prevention, which is started before infection, and secondary prevention, which prevents tuberculosis from progressing to active tuberculosis. Given the characteristics of tuberculosis bacteria that can be transmitted through air, proper air circulation (ventilation) is the most important way to prevent the transmission of tuberculosis into the community. Hospitals and clinics should take appropriate precautions to prevent the transmission of tuberculosis. A second preventive method is the use of prophylactic drugs, which are used to detect people with tuberculosis at an early stage and prevent the early detection of people from developing tuberculosis. For example, a method called isoniazid (INH) is administered to people infected with Mycobacterium tuberculosis but not yet developed into active tuberculosis, thereby preventing the development of active tuberculosis by eradicating the existing tuberculosis bacteria.
결핵의 2차 예방법으로 투여되는 이 약제는 6개월에서 9개월까지 매일 복용하게 되며, 일부 부작용이 발생하는 것을 주의하여야 한다. 이 약제의 대표적인 부작용은 약을 투여하는 사람들 중 일부에서 발생하는 ‘간염’인데, 특히 35세 이상의 사람들에서 빈도가 높은 것으로 확인되었다. 이러한 부작용으로 인하여 일부 국가에서는 35세 이상의 결핵 감염 환자는 아이소나이아지드를 투여하지 않고 경과를 관찰하다가, 활동성 결핵이 발생하게 되면 그 때 본격적으로 항결핵제를 투여하는 방법을 권장하고 있다. 각 나라별 결핵발생률에 따르면 미국의 결핵발생률은 0.05%로 매우 낮아 이러한 방법으로 예방하는 것이 권장되고 있는데 반하여, 우리나라의 경우는 결핵발생률이 이 숫자의 약 60배에 달하는 0.91%로, 미국보다 훨씬 높아 결핵의 예방을 위하여 아이소나이아지드라는 약물을 투여하는 것에 대하여 여러 의견이 있다. 현재, 우리나라에서는 결핵에 감염된 경우, 폭발적인 결핵균의 성장에 의하여 심한 전신 결핵을 앓기 쉬운 소아(6세 미만)를 제외하고는, 아이소나이아지드에 의한 예방법이 광범위하게 시행되고 있지 않지만, 최근에는 결핵의 예방치료에 대한 관심의 증가에 따라 아이소나이아지드에 의한 예방치료 대상을 더 넓혀가고 있는 추세이다.The drug, which is administered as a secondary preventive measure for tuberculosis, is taken daily for six to nine months, and some side effects should be noted. A typical side effect of the drug is hepatitis, which occurs in some people who take the drug, especially in people over 35 years of age. Because of these side effects, some countries over 35 years of age are advised to take anti-tuberculosis drugs when they are active without developing isoniazide. Tuberculosis incidence in each country is very low (0.05%), and it is recommended to prevent it by this method. In Korea, tuberculosis incidence is 0.91%, which is about 60 times that number, much more than in the United States. There are many opinions about the administration of a drug called isonazid to prevent tuberculosis. Currently, in Korea, tuberculosis infection, except for children (under 6 years old) who are susceptible to severe systemic tuberculosis due to explosive growth of tuberculosis bacteria, isoenazide preventive measures are not widely practiced recently, Increasing interest in preventive treatment is increasing the scope of preventive treatment by isonazid.
현재 이용되고 있는 결핵의 치료방법으로는, 통원치료와 내성획득을 예방하기 위하여 4제를 병용하는 것을 원칙으로 하나, 이러한 결핵치료의 가장 큰 문제점은 일차항결핵제에 대한 내성이 생기는 경우, 특별한 치료방법이 없다는 것이며, 효과적인 항결핵제의 개발과 체계적인 관리를 통하여 결핵발생률 및 결핵으로 인한 사망률이 감소하긴 하였지만, 최근에는, 최소한 두 가지 이상의 약제에 동시내성이 발생된 것을 의미하는 다제내성 결핵(MDR-TB)의 발생과 후천성면역결핍증(AIDS)의 유행으로 다시 결핵이 증가하고 있는 추세이다. 따라서 기존에 사용되고 있는 약제가 아닌 새로운 성분을 갖는 예방 및 치료제의 개발이 필요하다.As a rule of treatment for tuberculosis currently used, four drugs are used in combination to prevent hospitalization and to acquire resistance. However, the biggest problem of tuberculosis treatment is a special treatment method when resistance to primary anti-tuberculosis drugs occurs. Although the incidence of TB and mortality from tuberculosis have decreased through the development and systematic management of effective antituberculosis drugs, in recent years, at least two drugs have been resistant to multidrug-resistant tuberculosis (MDR-TB). Tuberculosis is on the rise again due to the occurrence of AIDS and the prevalence of AIDS. Therefore, there is a need for the development of prophylactic and therapeutic agents having new ingredients other than the existing drugs.
즉, 기존의 결핵 치료제는, 반복되어 사용되는 약물에 대한 내성이 생긴 경우가 대부분이고, 기존의 한의학의 방법을 이용하여 제조된 결핵 예방 및 치료제는 여러 가지 약용식물들을 혼합하는 방법을 이용하거나, 단지 수많은 식물들을 나열하는 방법을 이용하는 경우가 대부분이라는 문제가 있기에, 이러한 문제점을 극복할 수 있는 새로운 성분을 갖는 결핵 예방 및 치료제의 개발이 필요하다.In other words, the existing tuberculosis treatment agent, the resistance to the drug is used repeatedly in most cases, tuberculosis prevention and treatment prepared by using the traditional Chinese medicine method using a method of mixing a variety of medicinal plants, Since there is a problem that most of them use only a method of arranging a large number of plants, there is a need to develop a tuberculosis prevention and treatment with new ingredients that can overcome these problems.
한편, 기존의 결핵 예방 및 치료와 관련된 선행기술로는 공개특허 제10-2016-0105715호(발명의 명칭: 페난트레닐계 화합물 또는 이의 유도체, 및 이를 함유하는 결핵 치료용 약학조성물) 등이 있다.On the other hand, prior art related to the prevention and treatment of tuberculosis is disclosed in Korean Patent Publication No. 10-2016-0105715 (name of the invention: phenanthrenyl-based compounds or derivatives thereof, and pharmaceutical compositions for treating tuberculosis containing the same).
본 발명은 기존에 제안된 방법들의 상기와 같은 문제점들을 해결하기 위해 제안된 것으로서, 기존의 고가의 재료를 이용하며 여러 단계의 제조과정을 거치는 결핵 예방 및 치료를 위한 약제와는 달리, 일반 사용자가 일상생활에서 쉽게 구할 수 있는 재료를 이용하고, 단순한 제조과정으로 제조되어 비용이 저렴하여, 환자의 사망률이 높은 개발도상국에 대하여도, 결핵 예방에 크게 기여할 수 있는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법을 제공하는 것을 그 목적으로 한다.The present invention has been proposed to solve the above problems of the conventionally proposed methods, and unlike conventional medicines for the prevention and treatment of tuberculosis, which uses existing expensive materials and undergoes several steps of manufacturing, For the prevention of tuberculosis containing sumac extract, which can contribute greatly to the prevention of tuberculosis, even in developing countries with high mortality rates of patients, using materials readily available in daily life and manufactured by simple manufacturing processes. An object thereof is to provide a health food and a method of manufacturing the same.
또한, 본 발명은, 옻나무 추출물을 함유하는 결핵 예방 유효성분을 티백 또는 음료의 형태로 일반 사용자가 쉽게 섭취할 수 있도록 제공함으로써, 일반 사용자가 결핵 예방 유효성분을 섭취하는 섭취 비율이 높아짐에 따라, 결핵 예방에 도움을 줄 수 있는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법을 제공하는 것을 다른 목적으로 한다.In addition, the present invention, by providing a tuberculosis preventive active ingredient containing lacquer extract to the general user easily in the form of tea bags or beverages, as the intake rate of the general user to take the tuberculosis preventive active ingredient is increased, Another object of the present invention is to provide a tuberculosis preventive health food containing a sumac extract and a method for producing the same, which may help prevent tuberculosis.
뿐만 아니라, 본 발명은, 기존의 결핵 예방 및 치료를 위한 약물의 내성으로 인한 다제내성 결핵에 대한 적절한 치료 약물이 없는 경우에, 내성이 없는 신규한 결핵 예방 및 치료제로서 유용하게 이용될 수 있는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법을 제공하는 것을 또 다른 목적으로 한다.In addition, the present invention can be usefully used as a novel tuberculosis prevention and treatment without resistance, in the absence of a suitable therapeutic drug for multidrug-resistant tuberculosis due to the resistance of the drug for the prevention and treatment of tuberculosis, It is another object of the present invention to provide a health food for preventing tuberculosis containing the sumac extract and a method of manufacturing the same.
상기한 목적을 달성하기 위한 본 발명의 특징에 따른, 옻나무 추출물을 함유하는 결핵 예방용 건강식품은,Tuberculosis prevention health foods containing the sumac extract according to the characteristics of the present invention for achieving the above object,
결핵 예방용 건강식품으로서,As a health food for the prevention of tuberculosis,
옻나무 추출물을 유효성분으로 포함하는 것을 그 구성상의 특징으로 한다.Including the sumac extract as an active ingredient is characterized by its configuration.
바람직하게는, 상기 옻나무 추출물은,Preferably, the sumac extract,
60~70℃로 가열하여 추출될 수 있다.It may be extracted by heating to 60 ~ 70 ℃.
바람직하게는, 상기 옻나무 추출물은,Preferably, the sumac extract,
상기 옻나무의 총 중량대비 2~40배 중량의 용매를 사용하여 추출될 수 있다.It can be extracted using a solvent of 2 to 40 times the weight of the total weight of the lacquer.
바람직하게는, 상기 옻나무 추출물은,Preferably, the sumac extract,
티백에 포장되거나 음료에 포함된 상태일 수 있다.It may be packaged in a tea bag or included in a beverage.
또한, 상기한 목적을 달성하기 위한 본 발명의 특징에 따른, 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법은,In addition, according to the characteristics of the present invention for achieving the above object, a method for producing a tuberculosis prevention health food containing the sumac extract,
(1) 옻나무를 준비하는 단계; 및(1) preparing a sumac tree; And
(2) 상기 단계 (1)에서 준비된 옻나무로부터, 총 중량대비 2~40배 중량의 용매를 사용하여 옻나무의 추출물을 추출하는 단계를 포함하되, 상기 옻나무 추출물은 60~70℃로 가열하여 추출하는 것을 그 구성상의 특징으로 한다.(2) from the lacquer prepared in step (1), comprising extracting the extract of the lacquer using a solvent of 2 to 40 times the total weight by weight, the lacquer extract is extracted by heating to 60 ~ 70 ℃ It is characterized by the configuration thereof.
바람직하게는, 상기 옻나무 추출물은,Preferably, the sumac extract,
티백에 포장되거나 음료에 포함된 상태일 수 있다.It may be packaged in a tea bag or included in a beverage.
본 발명에서 제안하고 있는 옻나무 추출물을 함유하는 결핵 예방용 건강식품 및 그 제조방법에 따르면, 기존의 고가의 재료를 이용하며 여러 단계의 제조과정을 거치는 결핵 예방 및 치료를 위한 약제와는 달리, 일반 사용자가 일상생활에서 쉽게 구할 수 있는 재료를 이용하고, 단순한 제조과정으로 제조되어 비용이 저렴하여, 환자의 사망률이 높은 제3 국의 개발도상국에 대하여도, 결핵 예방에 크게 기여할 수 있다.According to the health food for preventing tuberculosis containing the lacquer extract proposed in the present invention and a method for manufacturing the same, unlike the drug for the prevention and treatment of tuberculosis using a conventional expensive material and undergoing a multi-step manufacturing process, In the developing countries of third countries, where the cost is low because the user uses materials readily available in daily life and is manufactured by a simple manufacturing process, the mortality rate of patients can be greatly contributed to the prevention of tuberculosis.
또한, 본 발명에 따르면, 옻나무 추출물을 함유하는 결핵 예방 유효성분을 티백 또는 음료의 형태로 일반 사용자가 쉽게 섭취할 수 있도록 제공함으로써, 일반 사용자가 결핵 예방 유효성분을 섭취하는 섭취 비율이 높아짐에 따라, 결핵 예방에 도움을 줄 수 있다.In addition, according to the present invention, by providing a tuberculosis preventive active ingredient containing the sumac extract so that the general user can easily in the form of tea bags or beverages, as the intake rate of the general user to take the tuberculosis preventive active ingredient increases It can help prevent tuberculosis.
뿐만 아니라, 본 발명에 따르면, 기존의 결핵 예방 및 치료를 위한 약물의 내성으로 인한 다제내성 결핵에 대한 적절한 치료 약물이 없는 경우에, 내성이 없는 신규한 결핵 예방 및 치료제로서 유용하게 이용될 수 있다.In addition, according to the present invention, in the absence of an appropriate therapeutic drug for multidrug-resistant tuberculosis due to resistance of drugs for existing tuberculosis prevention and treatment, it can be usefully used as a novel tuberculosis prevention and treatment without resistance. .
도 1은 우리나라의 연도별 결핵신환자 발생추이를 도시한 도면.1 is a view showing the development of tuberculosis patients in Korea year by year.
도 2는 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품에서 이용되는 옻나무의 일예를 도시한 도면.2 is a view showing an example of the lacquer tree used in the tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention.
도 3은 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법의 흐름을 도시한 도면.Figure 3 is a view showing the flow of a method for producing a tuberculosis prevention health food containing a sumac extract according to an embodiment of the present invention.
이하, 첨부된 도면을 참조하여 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 본 발명을 용이하게 실시할 수 있도록 바람직한 실시예를 상세히 설명한다. 다만, 본 발명의 바람직한 실시예를 상세하게 설명함에 있어, 관련된 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략한다. 또한, 유사한 기능 및 작용을 하는 부분에 대해서는 도면 전체에 걸쳐 동일한 부호를 사용한다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. However, in describing the preferred embodiment of the present invention in detail, if it is determined that the detailed description of the related known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted. In addition, the same reference numerals are used throughout the drawings for parts having similar functions and functions.
덧붙여, 명세서 전체에서, 어떤 부분이 다른 부분과 ‘연결’ 되어 있다고 할 때, 이는 ‘직접적으로 연결’ 되어 있는 경우뿐만 아니라, 그 중간에 다른 소자를 사이에 두고 ‘간접적으로 연결’ 되어 있는 경우도 포함한다. 또한, 어떤 구성요소를 ‘포함’ 한다는 것은, 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성요소를 더 포함할 수 있다는 것을 의미한다.In addition, in the specification, when a part is 'connected' to another part, it is not only 'directly connected' but also 'indirectly connected' with another element in between. Include. In addition, the term "comprising" a certain component means that the component may further include other components, except for the case where there is no contrary description.
본 명세서에 있어서, “유효성분”이라 함은 내재된 약리작용에 의해 그 조성물의 효능효과를 직접 또는 간접적으로 발현한다고 기대되는 물질 또는 물질군(약리학적 활성성분 등이 밝혀지지 않은 생약 등을 포함한다)으로서 주성분을 포함하는 것을 의미한다.In the present specification, the term "active ingredient" includes a substance or a group of substances (a pharmacologically active ingredient or the like which is expected to express the efficacy effect of the composition directly or indirectly by intrinsic pharmacological action). Means a main component).
도 1은 우리나라의 연도별 결핵신환자 발생추이를 도시한 도면이다. 도 1에 도시된 바와 같이, 연도별 결핵 환자 발생추이는 2003년까지는 점차 줄어드는 경향을 보였으나, 2004년부터는 다시 늘어나고 있는바, 이로부터, 결핵 예방의 필요성을 확인할 수 있다.1 is a view showing the development of tuberculosis patients in Korea by year. As shown in FIG. 1, the incidence of tuberculosis patients by year showed a tendency to decrease gradually until 2003, but has been increasing again since 2004, from which the necessity of tuberculosis prevention can be confirmed.
옻나무는 중국에서 전파된 식물로서, 옻나무과의 낙엽 교목에 해당되며 높이는 7~10미터이고, 잎은 7~11개의 작은 잎으로 이루어진 우상 복엽으로, 일반적으로 6월에 누런 녹색 단성화가 잎겨드랑이에서 피고, 열매는 핵과로 10월에 노란색으로 익는다. 도 2는 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품에서 이용되는 옻나무의 일예를 도시한 도면이다. 도 2에 도시된 바와 같이, 옻나무의 나무껍질 및 어린잎을 약용 또는 식용으로 사용하게 되며, 구체적으로는, 옻나무의 나무껍질에 상처를 내어 뽑은 진을 옻이라고 하며 이렇게 추출된 옻을 약용으로 사용하고 있는 것이다.Lacquer is a deciduous arboreous tree of China, which is a deciduous arborescent of the Lacaceae family, is 7 ~ 10m high, and is an idol of the leaf composed of 7 ~ 11 small leaves. The fruit ripens to yellow in October with the nucleus. Figure 2 is a view showing an example of the lacquer tree used in the tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention. As shown in FIG. 2, the bark and young leaves of the lacquer tree are used for medicinal or edible use. Specifically, the extract extracted from the bark of the lacquer tree is called lacquer and the extracted lacquer is used for medicinal purposes. I'm doing it.
한의학에서는 이러한 옻의 효능으로, 혈액순환 촉진, 구충, 복통, 위산과다, 진해, 폐결핵, 통경, 변비, 당뇨, 학질, 소염, 관절염, 방부, 건위, 항암 등에 효과가 있다고 알려져 있다. 또한 민간의학에서는 옻이 폐에서는 결핵균을 없애며, 간에서의 어혈, 심장에서의 청혈제 역할을 할 수 있으며, 그 외에도 신경통, 관절염, 피부병 등에도 효능이 있다고 확인되었다. 이러한 효능을 갖는 옻나무로부터 추출된 추출물의 성분으로는 대표적으로 우루시올과 플라보노이드 계통 및 페놀 화합물 계통 등이 밝혀져 있다.In oriental medicine, the effect of lacquer is known to be effective in promoting blood circulation, hookworm, abdominal pain, excessive stomach acid, cough, pulmonary tuberculosis, pain, constipation, diabetes, malaria, anti-inflammatory, arthritis, antiseptic, dry stomach, and anti-cancer. In folk medicine, lacquer removes tuberculosis bacteria from the lungs, acts as a blood donor in the liver and a blue blood agent in the heart, and is also effective in neuralgia, arthritis and skin diseases. Representative components of the extract extracted from the lacquer tree having such efficacy are known as urushiol and flavonoid strain and phenolic compound strain.
구체적으로는, 옻나무 추출물의 성분인 우루시올은 2~4PPM 농도에서 암세포를 죽이는 효과가 탁월한 것으로 실험결과를 통해 입증된 바 있으며, 옻나무의 목질부에 풍부한 성분인 각종 플라보노이드는, 신생혈관억제 효과로 암세포를 죽이는 작용을 하며, 혈관이나 모세혈관을 보호하고, 과산화 지질을 억제하며 알레르기나 피부질환을 억제하기도 한다. 또한, 플라보노이드는 간을 보호하는 작용을 하는 것으로 검증되었으며, 옻나무의 플라보노이드를 500㎎/㎖의 농도로 쥐에 2㎖ 투여한 결과, 40% 알콜을 투여한 쥐의 혈중 알콜 농도가 0.162%에서 0.014%로 감소된 것으로부터, 플라보노이드에 의한 간 보호의 효과를 확인할 수가 있다. 한편, 이러한 플라보노이드와는 달리, 우루시올은 암세포에 대한 강력한 세포독성 물질로서 작용하지만, 이와 동시에 강력한 알레르기 유발물질이기도 하므로, 우루시올 성분의 섭취량을 고려하여 사용하여야만 한다. 즉, 옻나무는 다양한 효능이 있음에도, 우루시올이라는 독성 성분이 있기 때문에 섭취량이 많지 않았으며, 기존의 식용을 위한 옻나무 추출물을 추출하는 기술로는 다양한 방법이 있으며, 대표적으로는 열수추출법, 효소추출법, 발효추출법 등의 방법이 알려져 있다.Specifically, urushiol, a component of the lacquer extract, has been proven to have excellent effects of killing cancer cells at a concentration of 2 to 4 PPM. Various flavonoids, which are abundant in the wood part of the lacquer tree, are used to suppress cancer cells by the neovascularization effect. It works by killing, protecting blood vessels and capillaries, inhibiting lipid peroxide, and inhibiting allergies and skin diseases. In addition, flavonoids have been shown to protect the liver, and 2 ml of lacquer flavonoids were administered to rats at a concentration of 500 mg / ml, resulting in a blood alcohol concentration of 0.162% to 0.014 in rats treated with 40% alcohol. From the decrease in%, the effect of liver protection by flavonoids can be confirmed. On the other hand, unlike these flavonoids, urushiol acts as a potent cytotoxic substance for cancer cells, but at the same time it is also a potent allergen, and therefore must be used in consideration of the intake of the urushiol component. In other words, the lacquer tree has a variety of effects, but because there is a toxic component called urushiol, the intake was not large.There are various techniques for extracting the lacquer extract for conventional edible, and typically, hot water extraction, enzyme extraction, and fermentation. Methods such as extraction methods are known.
본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품은, 결핵 예방용 건강식품으로서, 옻나무 추출물을 유효성분으로 포함하는 것을 그 구성상의 특징으로 한다.Tuberculosis prevention health foods containing the lacquer extract according to an embodiment of the present invention, as a health food for tuberculosis prevention, characterized in that the composition containing the sumac extract as an active ingredient.
본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품에 있어서, 옻나무 추출물을 추출하기 위하여, 옻나무를 물로 깨끗이 세척, 건조시키고 건조된 옻나무를 추출용기에 투입하며, 투입된 옻나무의 총 중량대비 2~40배 중량의 용매를 사용하여 추출물을 추출할 수 있다. 이러한 추출은 승온 후 실행될 수도 있고, 일정시간 가온 후 실행될 수도 있다. 보다 구체적으로는, 추출을 위하여 가열하는 온도는 60~70℃로 가열할 수 있으며, 실시예에 따라서는 64 ℃에서 가열하는 것이 바람직하다.In the tuberculosis preventive health food containing the lacquer extract according to an embodiment of the present invention, in order to extract the lacquer extract, the lacquer is thoroughly washed with water, dried and the dried lacquer is put into the extraction container, and the total of the lacquer Extract can be extracted using a solvent of 2 to 40 times the weight by weight. Such extraction may be performed after the temperature rises, or may be performed after a certain period of time. More specifically, the temperature to be heated for extraction can be heated to 60 ~ 70 ℃, depending on the embodiment it is preferable to heat at 64 ℃.
본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품에 있어서, 옻나무 추출을 위한 추출에 사용되는 용매는, 물, 특히 정제수를 용매로 사용하여 추출할 수 있으며, 에탄올, 메탄올 및 다른 용매의 사용도 가능하고, 추출 용매의 비율에 있어서, 물의 비율을 낮추고 용매의 비율을 높이는 방법을 이용함으로써, 수율은 줄어들지만 약효는 증가시키는 결과를 얻을 수 있다.In the tuberculosis preventive health food containing the lacquer extract according to an embodiment of the present invention, the solvent used for extracting the lacquer extract may be extracted using water, in particular, purified water as a solvent, ethanol, methanol and Other solvents can also be used, and by using a method of lowering the water ratio and increasing the solvent ratio in the ratio of the extraction solvent, the yield can be reduced but the effect of the drug can be increased.
본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 옻나무 추출물은, 티백에 포장되거나 음료에 포함된 상태일 수 있다. 추출물을 티백에 포장함으로써, 추출물의 이용성을 높일 수 있는데, 티백은 통상 사용되고 있는 부직포 등을 이용할 수 있고, 티백의 크기는 제한되지 않으며, 필요에 따라 5~100g씩 용량을 달리하여 포장할 수도 있다. 물론, 옻나무 추출물을 포함하는 형태는 티백, 음료에 한정되는 것이 아니며, 다른 실시예에 따라서는, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 및 멸균 주사용액의 형태로 제형화될 수도 있다.The lacquer extract of tuberculosis preventive health food containing the lacquer extract according to an embodiment of the present invention may be packaged in a tea bag or included in a beverage. By packaging the extract in a tea bag, the usability of the extract can be increased, but the tea bag can be used a nonwoven fabric or the like that is commonly used, and the size of the tea bag is not limited, and may be packaged in different capacities of 5 to 100 g as necessary. . Of course, the form containing the sumac extract is not limited to tea bags and beverages, and according to another embodiment, oral formulations such as granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, and sterilization It may be formulated in the form of an injection solution.
본 발명의 옻나무 추출물을 포함한 건강식품은, 지시된 비율을 필수 성분으로서 함유하는 것 외에는, 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로 함유할 수도 있다. 이 외에 본 발명의 건강식품은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제, 펙트산 및 그의 염, ph조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 본 발명은 천연 과일 주스 및 과일 주스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있고, 다양한 성분은 독립적으로 사용하거나 조합하여 사용될 수도 있다.The health food including the lacquer extract of the present invention is not particularly limited to other ingredients except for containing the indicated ratios as essential ingredients, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. have. In addition, the health food of the present invention is a variety of nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, such as flavoring agents, coloring and neutralizing agents, pectic acid and salts thereof, ph regulators, stabilizers, preservatives, Glycerol, alcohols, carbonation agents used in carbonated drinks, and the like. In addition, the present invention may contain a flesh for preparing natural fruit juices and fruit juice beverages and vegetable beverages, and various components may be used independently or in combination.
이하에서는, 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법을 설명하도록 한다.Hereinafter, to explain the manufacturing method of the tuberculosis preventive health food containing the sumac extract according to an embodiment of the present invention.
도 3은 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법의 흐름을 도시한 도면이다. 도 3에 도시된 바와 같이, 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법은, 옻나무를 준비하는 단계(S10), 및 단계 S10에서 준비된 옻나무를 총 중량대비 2~40배 중량의 용매를 사용하여 옻나무의 추출물을 추출하는 단계(S20)를 포함하되, 옻나무 추출물은 60~70℃로 가열하여 추출하는 것을 그 구성상의 특징으로 한다. 실시예에 따라서는, 단계 S20에서 추출된 옻나무 추출물은 티백에 포장되거나 음료에 포함된 형태로 제공될 수 있다.Figure 3 is a view showing the flow of a method for producing a tuberculosis prevention health food containing a sumac extract according to an embodiment of the present invention. As shown in Figure 3, the method for producing a tuberculosis prevention health food containing the lacquer extract according to an embodiment of the present invention, preparing the lacquer (S10), and the sumac prepared in step S10 compared to the total weight Extracting the extract of the lacquer using the solvent of 2 to 40 times the weight (S20), the extract of the lacquer is characterized by its configuration that is extracted by heating to 60 ~ 70 ℃. According to an embodiment, the sumac extract extracted in step S20 may be provided in a form packed in a tea bag or included in a beverage.
한편, 상기와 같은 제조방법에 의해 제조된 본 발명의 일실시예에 따른 옻나무 추출물을 함유하는 결핵 예방용 건강식품은 적정한 1회 용량씩 개별 포장되거나 용기에 일괄 포장될 수 있다.On the other hand, tuberculosis preventive health foods containing the lacquer extract according to an embodiment of the present invention prepared by the manufacturing method as described above may be individually packaged in a single dose or packaged in a container.
본 발명은 이하의 실시예에 의하여 더욱 상세히 설명되나, 본 발명이 이하의 실시예에 의해 어떤 식으로든 제한되는 것은 아니다.The present invention is described in more detail by the following examples, but the present invention is not limited in any way by the following examples.
[실시예 1]Example 1
본 발명에서 제안하는 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조 Preparation of tuberculosis preventive health food containing lacquer extract proposed in the present invention
준비된 옻나무를 물로 깨끗이 세척한 후 건조시키고, 건조된 옻나무를 추출용기에 투입한다. 투입된 옻나무의 총 중량대비 2~40배 중량의 용매를 사용하여 추출물을 추출할 수 있으며, 추출에 사용되는 용매로는 물, 특히 정제수를 사용한다. 용매의 온도가 60~70℃로 가온된 후 일정시간 동안 추출을 실행하며, 보다 구체적으로는, 용매의 온도가 64℃가 되었을 때, 추출물을 획득하며, 이렇게 획득된 추출물을 티백에 포장하거나 음료에 포함시킴으로써 제조할 수 있다.The prepared lacquer is thoroughly washed with water and dried, and the dried lacquer is put into the extraction container. The extract can be extracted using a solvent of 2 to 40 times the total weight of the sumac put, and water, in particular purified water is used as the solvent used for extraction. Extraction is performed for a predetermined time after the temperature of the solvent is warmed to 60-70 ° C., more specifically, when the temperature of the solvent reaches 64 ° C., the extract is obtained, and the extract thus obtained is packaged in a tea bag or a beverage. It can manufacture by including in the.
이하에서는, 본 발명의 효과를 실험예를 통하여 더욱 상세하게 설명하지만, 본 발명의 권리범위가 하기 실험예에 의해 한정되는 것은 아니다.Hereinafter, the effects of the present invention will be described in more detail through experimental examples, but the scope of the present invention is not limited by the following experimental examples.
실험예 1. 결핵 예방 및 개선 효과 실험Experimental Example 1. Tuberculosis prevention and improvement effect experiment
본 발명에서 제안하고 있는 옻나무 추출물을 함유하는 결핵 예방용 건강식품에 의한 결핵 예방 및 개선 효과를 확인하기 위하여 하기와 같이 인체 실험을 진행하였다.In order to confirm the tuberculosis prevention and improvement effect by the tuberculosis prevention health food containing the lacquer extract proposed in the present invention, the human experiment was carried out as follows.
1. 실험대상 및 기간1. Subject and Period
본 실험은 결핵 초기 증상이 있는 30세~50세의 남자, 여자 각각 10명의 총 20명을 실험대상으로 하였고, 실험기간은 3개월로 하였다.In this experiment, a total of 20 men and 10 women aged 30 to 50 with early symptoms of tuberculosis were included in the study. The duration of the experiment was 3 months.
2. 실험방법2. Experimental method
총 20명의 피시험자들에게 실시예 1에서 제조된 건강식품을, 1일 2회 아침, 저녁으로 복용하게 하였다. 복용 12주일 후, 피시험자들의 결핵 예방 및 개선 정도를 설문을 통해 파악하여 결핵 예방 및 개선 효과를 파악하였다.A total of 20 test subjects were given the health food prepared in Example 1 twice a day in the morning and evening. After 12 weeks of administration, the degree of tuberculosis prevention and improvement of the subjects was checked through a questionnaire to determine the effect of tuberculosis prevention and improvement.
3. 결과3. Results
본 발명에서 제안하는 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 복용 후의 결핵 예방 및 개선 효과 평가 결과를 표 1에 나타내었다.Table 1 shows the results of the TB prevention and improvement effect after taking the tuberculosis preventive health food containing the lacquer extract proposed in the present invention.
표 1
구분 결핵 예방 및 개선 효과
(명) (%)
1개월 후 매우 개선 1 5.0
개선 4 20.0
보통 12 60.0
악화 2 10.0
매우 악화 1 5.0
2개월 후 매우 개선 3 15.0
개선 7 35.0
보통 9 45.0
악화 1 5.0
매우 악화 - -
3개월 후 매우 개선 5 25.0
개선 8 40.0
보통 7 35.0
악화 - -
매우 악화 - -
Table 1
division Tuberculosis prevention and improvement
(persons) (%)
1 month later Very improved One 5.0
Improving 4 20.0
usually 12 60.0
worse 2 10.0
Very worse One 5.0
2 months later Very improved 3 15.0
Improving 7 35.0
usually 9 45.0
worse One 5.0
Very worse - -
3 months later Very improved 5 25.0
Improving 8 40.0
usually 7 35.0
worse - -
Very worse - -
표 1에 나타난 바와 같이, 본 발명의 실시예 1에 따라 제조된 건강식품을 복용한 피시험자들은 복용 1개월 후에는 25%, 2개월 후에는 50%, 3개월 후에는 65%가 개선 효과가 있었다고 답하였는바, 본 발명에서 제안하는 옻나무 추출물을 함유하는 결핵 예방용 건강식품은, 결핵 증상을 예방하고 개선시키는데 효과적임을 확인할 수 있었다.As shown in Table 1, the test subjects taking the health food prepared according to Example 1 of the present invention had an improvement effect of 25% after one month, 50% after two months, and 65% after three months. It was found that the health food for preventing tuberculosis containing the lacquer extract proposed by the present invention was effective in preventing and improving tuberculosis symptoms.
실험예 2.Experimental Example 2. 독성 실험Toxicity Test
중앙실험동물(ICR 마우스)을 이용하여 독성 실험을 하였으며, 각 군당 10마리로 하여 본 발명의 옻나무 추출물을 5g/㎏/10㎖의 용량으로 경구 투여한 후, 동물의 폐사 여부, 임상증상, 및 체중변화를 관찰하여 혈액학적 검사를 하였다. 반복 투여 실험으로서, 2g/㎏/10㎖의 용량으로 10회 반복 경구 투여하였으며, 그 결과 모든 동물에서 폐사되거나 혈액검사, 체중변화 등에서도 특이한 변화 및 독성변화는 관찰되지 않았다. 이와 같은 독성 실험을 통하여, 옻나무 추출물은 5000g/kg까지 독성변화가 나타나지 않았으며, 경구 투여 최소 치사량은 5000g/㎏ 이상인 안전한 물질로 판단되었다.Toxicity experiments were carried out using a central laboratory animal (ICR mouse), and 10 rats of each group were orally administered with the lacquer extract of the present invention at a dose of 5 g / kg / 10ml, and there were no animal deaths, clinical symptoms, and Hematological examination was performed by monitoring the weight change. As a repeated administration experiment, 10 oral doses were repeatedly administered at a dose of 2 g / kg / 10 ml, and as a result, no specific changes or toxicity changes were observed in all animals, even in blood tests and weight changes. Through the toxicity test, the sumac extract did not show toxicity change up to 5000g / kg, and the minimum lethal dose for oral administration was determined to be more than 5000g / kg.
상기와 같이 실험한 결과 옻나무 추출물은 급성독성 실험과 반복 투여 실험에서 치사 개체가 발생하지 않았으며, 부작용이 육안으로 관찰되지 않았는바, 옻나무 추출물의 경구 투여에 의한 독성은 발현되지 않는 것으로 나타났다.As a result of the experiment, the lacquer extract did not cause lethal individuals in the acute toxicity test and the repeated administration test, and no side effects were observed by the naked eye, and thus the toxicity was not expressed by oral administration of the lacquer extract.
이상 설명한 본 발명은 본 발명이 속한 기술분야에서 통상의 지식을 가진 자에 의하여 다양한 변형이나 응용이 가능하며, 본 발명에 따른 기술적 사상의 범위는 아래의 특허청구범위에 의하여 정해져야 할 것이다.The present invention described above may be variously modified or applied by those skilled in the art, and the scope of the technical idea according to the present invention should be defined by the following claims.

Claims (6)

  1. 결핵 예방용 건강식품으로서,As a health food for the prevention of tuberculosis,
    옻나무 추출물을 유효성분으로 포함하는 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품.Tuberculosis prevention health foods containing the sumac extract, comprising the sumac extract as an active ingredient.
  2. 제1항에 있어서, 상기 옻나무 추출물은,According to claim 1, The sumac extract,
    60~70℃로 가열하여 추출하는 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품.Tuberculosis prevention health food containing sumac extract, characterized in that the extract by heating to 60 ~ 70 ℃.
  3. 제1항에 있어서, 상기 옻나무 추출물은,According to claim 1, The sumac extract,
    상기 옻나무의 총 중량대비 2~40배 중량의 용매를 사용하여 추출하는 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품.Tuberculosis prevention health foods containing the sumac extract, characterized in that the extract using a solvent of 2 to 40 times the weight of the sum of the sumac.
  4. 제1항에 있어서, 상기 옻나무 추출물은,According to claim 1, The sumac extract,
    티백에 포장되거나 음료에 포함된 상태인 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품.Tuberculosis preventive health foods containing the sumac extract, characterized in that the packaged in a tea bag or contained in a beverage.
  5. 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법으로서,As a method for producing a tuberculosis preventive health food containing the sumac extract,
    (1) 옻나무를 준비하는 단계; 및(1) preparing a sumac tree; And
    (2) 상기 단계 (1)에서 준비된 옻나무로부터, 총 중량대비 2~40배 중량의 용매를 사용하여 옻나무의 추출물을 추출하는 단계를 포함하되, 상기 옻나무 추출물은 60~70℃로 가열하여 추출하는 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법.(2) from the lacquer prepared in step (1), comprising extracting the extract of the lacquer using a solvent of 2 to 40 times the total weight by weight, the lacquer extract is extracted by heating to 60 ~ 70 ℃ A method for producing a tuberculosis preventive health food containing the sumac extract.
  6. 제5항에 있어서, 상기 옻나무 추출물은,The method of claim 5, wherein the sumac extract,
    티백에 포장되거나 음료에 포함된 상태인 것을 특징으로 하는, 옻나무 추출물을 함유하는 결핵 예방용 건강식품의 제조방법.Method for producing a tuberculosis preventive health food containing a sumac extract, characterized in that the state is packaged in a tea bag or contained in a beverage.
PCT/KR2017/012631 2017-01-22 2017-11-08 Health food containing sumac extract for tuberculosis prevention and manufacturing method therefor WO2018135733A1 (en)

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Citations (5)

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Publication number Priority date Publication date Assignee Title
KR20010008353A (en) * 2000-11-25 2001-02-05 박인복 Beverage containing lacquer tree extracts
US20040076646A1 (en) * 2001-07-18 2004-04-22 Caplan Michael J. Haptenizing cancer cell components
JP2006503036A (en) * 2002-09-12 2006-01-26 ウィルフレッド−ラミックス インク Compositions for treating AIDS and related symptoms
KR20110107783A (en) * 2011-09-14 2011-10-04 한국과학기술연구원 Compositions for prevention and improvement of cancer containing the extracts of rhus trichocarpa as an active ingredient
KR20160082568A (en) * 2014-12-30 2016-07-08 김옥순 Composition comprising Rhus verniciflua for extraction and extraction mthod of the Composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010008353A (en) * 2000-11-25 2001-02-05 박인복 Beverage containing lacquer tree extracts
US20040076646A1 (en) * 2001-07-18 2004-04-22 Caplan Michael J. Haptenizing cancer cell components
JP2006503036A (en) * 2002-09-12 2006-01-26 ウィルフレッド−ラミックス インク Compositions for treating AIDS and related symptoms
KR20110107783A (en) * 2011-09-14 2011-10-04 한국과학기술연구원 Compositions for prevention and improvement of cancer containing the extracts of rhus trichocarpa as an active ingredient
KR20160082568A (en) * 2014-12-30 2016-07-08 김옥순 Composition comprising Rhus verniciflua for extraction and extraction mthod of the Composition

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