WO2018124475A3 - Recombinant microorganism having xenogeneic gene introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism - Google Patents

Recombinant microorganism having xenogeneic gene introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism Download PDF

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Publication number
WO2018124475A3
WO2018124475A3 PCT/KR2017/013171 KR2017013171W WO2018124475A3 WO 2018124475 A3 WO2018124475 A3 WO 2018124475A3 KR 2017013171 W KR2017013171 W KR 2017013171W WO 2018124475 A3 WO2018124475 A3 WO 2018124475A3
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WO
WIPO (PCT)
Prior art keywords
carbon dioxide
microorganism
formic acid
useful material
gene introduced
Prior art date
Application number
PCT/KR2017/013171
Other languages
French (fr)
Korean (ko)
Other versions
WO2018124475A2 (en
Inventor
이상엽
방준호
Original Assignee
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020170151642A external-priority patent/KR102000755B1/en
Application filed by 한국과학기술원 filed Critical 한국과학기술원
Priority to US16/472,876 priority Critical patent/US11214816B2/en
Priority to CN201780084543.8A priority patent/CN110234766B/en
Priority to DE112017006592.5T priority patent/DE112017006592T5/en
Priority to IL267579A priority patent/IL267579B1/en
Publication of WO2018124475A2 publication Critical patent/WO2018124475A2/en
Publication of WO2018124475A3 publication Critical patent/WO2018124475A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a recombinant microorganism having a xenogeneic gene introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention provides a novel microorganism having a cyclic metabolic pathway introduced thereto through which C3 or higher carbon organic compounds can be synthesized from formic acid and carbon dioxide, whereby carbon dioxide rich in nature and formic acid that is of low toxicity and suitable for anabolic reaction in view of reaction kinetics and which can be easily and rapidly synthesized from carbon dioxide can be used to effectively synthesize the C3 organic compound pyruvic acid from which various high-value added compound can be synthesized.
PCT/KR2017/013171 2016-12-27 2017-11-20 Recombinant microorganism having xenogeneic gene introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism WO2018124475A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US16/472,876 US11214816B2 (en) 2016-12-27 2017-11-20 Recombinant microorganism having heterologous genes introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism
CN201780084543.8A CN110234766B (en) 2016-12-27 2017-11-20 Recombinant microorganism having foreign gene introduced therein and method for producing useful material from formic acid and carbon dioxide using the same
DE112017006592.5T DE112017006592T5 (en) 2016-12-27 2017-11-20 RECOMBINANT MICROORGANISM WITH INTEGRATED XENOGENIC GENE AND METHOD FOR PRODUCING USEFUL MATERIAL FROM ANTIC ACID AND CARBON DIOXIDE USING THE SAME MICRO-ORGANISM
IL267579A IL267579B1 (en) 2016-12-27 2017-11-20 Recombinant microorganism having heterologous genes introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160180223 2016-12-27
KR10-2016-0180223 2016-12-27
KR10-2017-0151642 2017-11-14
KR1020170151642A KR102000755B1 (en) 2016-12-27 2017-11-14 A recombinant microorganism introduced exotic genes and a method for producing useful product from carbon dioxide and formic acid using the recombinant microorganism

Publications (2)

Publication Number Publication Date
WO2018124475A2 WO2018124475A2 (en) 2018-07-05
WO2018124475A3 true WO2018124475A3 (en) 2018-08-23

Family

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Application Number Title Priority Date Filing Date
PCT/KR2017/013171 WO2018124475A2 (en) 2016-12-27 2017-11-20 Recombinant microorganism having xenogeneic gene introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism

Country Status (1)

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WO (1) WO2018124475A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112920984A (en) * 2021-02-05 2021-06-08 南京工业大学 Construction is based on formic acid and CO2Method and application of growing recombinant strain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100679638B1 (en) * 2005-08-19 2007-02-06 한국과학기술원 Microorganisms transformed with gene encoding formate ddehydrogenase d or e and method for preparing succinic acid using the same
KR20090117739A (en) * 2007-02-09 2009-11-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 Biofuel production by recombinant microorganisms
JP2014155455A (en) * 2013-02-15 2014-08-28 Sekisui Chem Co Ltd RECOMBINANT CELLS AND METHOD FOR PRODUCING CROTONYL-CoA OR CROTYL ALCOHOL
US20150218528A1 (en) * 2012-07-29 2015-08-06 Yeda Research And Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100679638B1 (en) * 2005-08-19 2007-02-06 한국과학기술원 Microorganisms transformed with gene encoding formate ddehydrogenase d or e and method for preparing succinic acid using the same
KR20090117739A (en) * 2007-02-09 2009-11-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 Biofuel production by recombinant microorganisms
US20150218528A1 (en) * 2012-07-29 2015-08-06 Yeda Research And Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
JP2014155455A (en) * 2013-02-15 2014-08-28 Sekisui Chem Co Ltd RECOMBINANT CELLS AND METHOD FOR PRODUCING CROTONYL-CoA OR CROTYL ALCOHOL

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CROWTHER, GREGORY J.: "Formate as the main branch point for methylotrophic metabolism in Methylobacterium extorquens AMI", JOURNAL OF BACTERIOLOGY, vol. 190, no. 14, 2008, pages 5057 - 5062, XP055537039 *

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