IN2014MN01770A - - Google Patents

Info

Publication number
IN2014MN01770A
IN2014MN01770A IN1770MUN2014A IN2014MN01770A IN 2014MN01770 A IN2014MN01770 A IN 2014MN01770A IN 1770MUN2014 A IN1770MUN2014 A IN 1770MUN2014A IN 2014MN01770 A IN2014MN01770 A IN 2014MN01770A
Authority
IN
India
Prior art keywords
protected
oligopeptide
optionally
organic solvent
subtilisin
Prior art date
Application number
Inventor
Peter Jan Leonard Mario Quaedflieg
Timo Nuijens
Original Assignee
Enzypep B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzypep B V filed Critical Enzypep B V
Publication of IN2014MN01770A publication Critical patent/IN2014MN01770A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Method for enzymatically synthesising an oligopeptide comprising the coupling of an (optionally N protected) protected oligopeptide ester with an (optionally C protected) protected oligopeptide nucleophile in an organic solvent or an organic solvent mixture having a water content of 0.1 vol% or less by a subtilisin in any possible form.
IN1770MUN2014 2012-02-29 2013-02-28 IN2014MN01770A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12157571.6A EP2634193B1 (en) 2012-02-29 2012-02-29 Side-chain protected oligopeptide fragment condensation using subtilisins in organic solvents
PCT/NL2013/050125 WO2013129926A1 (en) 2012-02-29 2013-02-28 Side-chain protected oligopeptide fragment condensation using subtilisins in organic solvents

Publications (1)

Publication Number Publication Date
IN2014MN01770A true IN2014MN01770A (en) 2015-07-03

Family

ID=47884473

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1770MUN2014 IN2014MN01770A (en) 2012-02-29 2013-02-28

Country Status (9)

Country Link
US (1) US9598714B2 (en)
EP (1) EP2634193B1 (en)
JP (1) JP2015508666A (en)
CN (1) CN104284901A (en)
CA (1) CA2864865A1 (en)
DK (1) DK2634193T3 (en)
ES (1) ES2531054T3 (en)
IN (1) IN2014MN01770A (en)
WO (1) WO2013129926A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2650451T3 (en) * 2010-12-21 2018-01-18 Cj Cheiljedang Corporation Polypeptide variant that has homoserine acetyltransferase activity and microorganism that expresses the same
WO2016056913A1 (en) 2014-10-10 2016-04-14 Enzypep B.V. Peptide fragment condensation and cyclisation using a subtilisin variant with improved synthesis over hydrolysis ratio
US10752931B2 (en) * 2015-07-09 2020-08-25 Enzypep B.V. Designing an enzymatic peptide fragment condensation strategy
WO2020030663A1 (en) * 2018-08-09 2020-02-13 F. Hoffmann-La Roche Ag Cleavable linker for peptide synthesis
WO2023086502A1 (en) * 2021-11-12 2023-05-19 Virginia Tech Intellectual Properties, Inc. Hydrolyzed protein serum replacement compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6509727A (en) * 1965-07-28 1967-01-30
US5316935A (en) 1992-04-06 1994-05-31 California Institute Of Technology Subtilisin variants suitable for hydrolysis and synthesis in organic media
ES2332062T3 (en) * 2005-04-01 2010-01-25 Intezyne Technologies Incorporated POLYMER MICELLS FOR THE SUPPLY OF PHARMACOS.
CN102216324B (en) * 2008-11-19 2014-02-12 帝斯曼知识产权资产管理有限公司 Peptide synthesis using enzymatic activation and coupling

Also Published As

Publication number Publication date
US9598714B2 (en) 2017-03-21
ES2531054T3 (en) 2015-03-10
EP2634193A1 (en) 2013-09-04
WO2013129926A1 (en) 2013-09-06
JP2015508666A (en) 2015-03-23
US20150037840A1 (en) 2015-02-05
CA2864865A1 (en) 2013-09-06
CN104284901A (en) 2015-01-14
EP2634193B1 (en) 2015-01-14
DK2634193T3 (en) 2015-03-02

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