Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/01—Non-adhesive bandages or dressings
  • A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
  • A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/00051—Accessories for dressings
  • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
  • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/01—Non-adhesive bandages or dressings
  • A61F13/01034—Non-adhesive bandages or dressings characterised by a property
  • A61F13/01038—Flexibility, stretchability or elasticity
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/01—Non-adhesive bandages or dressings
  • A61F13/01034—Non-adhesive bandages or dressings characterised by a property
  • A61F13/01046—Air-vapor permeability
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/425—Porous materials, e.g. foams or sponges
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/44—Medicaments
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
  • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
  • B01D69/10—Supported membranes; Membrane supports
  • B01D69/107—Organic support material
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
  • B01D69/12—Composite membranes; Ultra-thin membranes
  • B01D69/125—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
  • B01D71/06—Organic material
  • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
  • B01D71/80—Block polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F2013/00089—Wound bandages
  • A61F2013/00217—Wound bandages not adhering to the wound
  • A61F2013/00221—Wound bandages not adhering to the wound biodegradable, non-irritating
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F2013/00089—Wound bandages
  • A61F2013/00246—Wound bandages in a special way pervious to air or vapours
  • A61F2013/00255—Wound bandages in a special way pervious to air or vapours with pores
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
  • A61F13/84—Accessories, not otherwise provided for, for absorbent pads
  • A61F2013/8473—Accessories, not otherwise provided for, for absorbent pads for diagnostic purposes
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2313/00—Details relating to membrane modules or apparatus
  • B01D2313/66—Biodegradability of parts of the module
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2313/00—Details relating to membrane modules or apparatus
  • B01D2313/68—Biocompatibility of parts of the module
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2323/00—Details relating to membrane preparation
  • B01D2323/15—Use of additives
  • B01D2323/18—Pore-control agents or pore formers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/02—Details relating to pores or porosity of the membranes
  • B01D2325/021—Pore shapes
  • B01D2325/0212—Symmetric or isoporous membranes
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/02—Details relating to pores or porosity of the membranes
  • B01D2325/0283—Pore size
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/02—Details relating to pores or porosity of the membranes
  • B01D2325/0283—Pore size
  • B01D2325/02832—1-10 nm
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/02—Details relating to pores or porosity of the membranes
  • B01D2325/0283—Pore size
  • B01D2325/02833—Pore size more than 10 and up to 100 nm
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/20—Specific permeability or cut-off range
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D2325/00—Details relating to properties of membranes
  • B01D2325/48—Antimicrobial properties

Definitions

• gauze Another approach to treating severe wounds is the use of multiple layers of gauze and medical tape.
• the gauze promotes breathability, but they quickly get saturated with fluids over time and are not resistant to pathogens on the nanoscale. So, healthcare providers must regularly change gauze dressings as well (typically every 8 hours).
• FIG. 1 illustrates the multilayer composite bandage of the invention
• FIG. 2 is scanning electron microscope (SEM) image of a nanoporous block copolymer membrane showing highly uniform pore size distribution of the invention.
• FIG. 3 is illustrates a further embodiment of the present invention including two distinct membranes with tunable pore size.
• Embodiments relate to articles that include at least one isoporous, self-assembled nanoporous membrane and a support, where the membrane and/or support is biocompatible.
• the tailored articles include external bandages, artificial skin grafts, internal bandages for hernias, and cell scaffolding.
• the article 1 (composite or bandage) includes a membrane 2, tuned pores 3, and support 4.
• FIG. 3 shows the addition of a second membrane 5, with tuned pores 6 different in size than pores 3.
• FIG. 2 is an SEM image of the surface of the membrane 2 surface.
• the present inventions provide bandages and kits including isoporous, self-assembled nanoporous membrane having tuned pore sizes ranging from 1 to 60, 100, 200 nm and at least one layer of a flexible, resilient, and/or elastic support layer, which can also be biocompatible.
• At least one of the support and membrane layers can include an agent that minimizes/reduces sticking to the wound, and can be provided by coating, spraying, or directly incorporating the agent with at least one of the isoporous membrane and support layers.
• isoporous means having a substantially narrow pore diameter distribution.
• the membranes of the present invention can be biocompatible for contact with skin/wound or internal use, can be formed from polymeric components that render them
• biodegradable for temporary use can include antibacterial/microbial agents for sterilizing a wound, can include non-stick agents for release from wound site, can include stiction agents or coating for adhesion to external or internal tissue, can include agents and provide a pore size suitable for enhancing cell growth, and can include drug eluting small molecule(s) and/or biologic(s).
• the additional functionality of the membrane of the present invention can include biocompatibility, antibacterial/microbial activity, wound release, drug elution, cell growth enhancement and can be provided by thin film coatings (e.g., dip coating, spray coating, vapor deposition), surface modification (e.g., covalent modification, grafting both to and from, electrostatic attraction (e.g. layer-by-layer, small molecule electrostatic adhesion), varying the membrane polymer chemistry, gas cluster ion beam surface modification, and pore size tunability.
• thin film coatings e.g., dip coating, spray coating, vapor deposition
• surface modification e.g., covalent modification, grafting both to and from
• electrostatic attraction e.g. layer-by-layer, small molecule electrostatic adhesion
• varying the membrane polymer chemistry gas cluster ion beam surface modification, and pore size tunability.
• each membrane layer can each have a pore size ranging from 1 to 60 nm, or discrete layers can have a specific pore or different pore size ranges (e.g., 1-30 nm, 10-40 nm, 20-50 nm, 20-40 nm, 20-60 nm). Layers of different size pore ranges/sizes can be combined for additional functionality.
• a composite bandage system can have a fabric with multiple layers, each layer providing specific properties.
• the fabric must contain a tailored nanoporous, polymeric membrane (providing breathability ranging from greater than about 960 g/m 2 to less than 3200 g/m 2 , regulation of moisture, and pathogen resistance), and a porous backing material that provides mechanical/structural properties, e.g., a support.
• the bandage system can be provided as a continuous roll, scored or unscored.
• the bandage fabric support can be longitudinally elastic and tearable in warp or weft direction. Alternatively the bandage system can be provided in discrete sizes of any dimension, e.g., 2 x 2", 2 x 4", 4 x 4", 6 x 8".
• the bandage system of the present invention can also be provided as a kit where pathogen specific bandages can be provided as an assortment of pre-assembled bandages, for specific classes of pathogens, specific pathogen species, and specific pharmaceutical treating agents that can also be tailored for a patient or type of wound.
• the kit includes different pathogen specific bandages, such as, at least one first bandage where isoporous, self-assembled nanoporous membrane having a pore size of from 1 to 60 nm, at least one second bandage with an isoporous, self- assembled nanoporous membrane with a pore size of from 1 to 100 nm, and additional bandages with an isoporous, self-assembled nanoporous membrane having other pore sizes, including at least a pore size of from 1 to 200 nm.
• the bandages of the kit can provide at least one of
• the bandage whether designed for a broad spectrum of pathogens, or tailored to a specific pathogen would be selected and applied to a wound such that either the tuned nanoporous membrane or support layer would face/contact the wound, in which case the materials used for the facing layer should be biocompatible, non-leaching, and able to come in direct contact with the open wound, shown in Figure 1.
• a bio-compatible non-sticking agent such as a silicone resin, could be combined with either the membrane or support to allow either side of the bandage system to contact a wound.
• the nanoporous, polymeric membrane layers should be highly permeable to air, but impervious to pathogens.
• Pathogens can include bacteria, viruses, protozoa, or algae, generally 0.01 to 0.1 ⁇ in size for most viruses and 0.1 to 20 ⁇ in size for bacteria.
• Bacteria are spherical (cocci), rod (bacilli) or spiral (spirochetes) in shape, and are also classified as being gram-positive, e.g., Staphylococcus aureus, non-haemolytic streptococci, Beta-haemolytic streptococcus; gram- negative, e.g., Escherichia coli, Pseudomonas aeruginosa, Klebsiella species, Proteus species.
• Other pathogens includes anerobes, e.g., Bacteroides and Clostridium; and fungi, e.g., Candida albicans and Aspergillus.
• Air permeability and pathogen impermeability is achieved through the use of self- assembled block copolymers that form isoporous membranes with pore sizes ranging from 1 to 60 nm, shown in the SEM of Figure 2.
• the high density of pores gives the membrane higher permeability while the isoporosity acts as a size selection barrier for various pathogens of interest.
• the pore sizes can also be uniformly tuned to control moisture transmission above the wound site.
• the membrane is a multi-block copolymer having at least one hydrogen-bonding block and a hydrophobic block. Suitable hydrogen bonding blocks include, but are not limited to,
• Suitable hydrophobic blocks can include, but are not limited to polystyrenes, e.g., polystyrene and poly (alkyl substituted styrene), such as, poly (alpha-methyl styrene); polyethylenes, polypropylenes, polyvinyl chlorides, and polytetrafluoroethylenes including expanded PTFE.
• the porous backing material simply acts as a mechanical substrate for the nanoporous, polymeric membrane. It should have pore sizes that are much larger than the polymeric membrane so as not to create a bottleneck for permeability, and it should convey mechanical stability and flexibility to the composite bandage.
• Suitable materials could include a knitted, woven or nonwoven material, such as gauze, cellulose-based fabrics, cotton, rayon, polyesters, polyethylenes, and open structure polyurethane film, all of which are sufficiently breathable to allow air to easily flow to and access the site of a wound.
• Typical bandage sizes could match existing standard sizes (e.g. 4 x 4" or 6 x 8") or could be envisioned as a wrap with some self-adhesive material.
• Alternatives include various material compositions for the various layers, thicknesses of the various layers, as well as variations in the pore size range and degree of isoporosity in the membrane layer. Additional layers can also be added to the stack to provide additional functionality (e.g. biocompatibility, medicinal properties, etc.)
• Parameters that provide the necessary protection are the use of a nanoporous, polymeric membrane as a bandage material for wound care.
• the pore size can range from a few nm and up, which will be important to define control of moisture, transmission rates and rejection of various pathogens.
• the solvent 1,4-dioxane alone or combined with tetrahydrofuran (THF), methanol, ethanol, toluene, chloroform, dimethylformamide, acetone, and dimethyl sulfoxide, is used as the solvent in preparing an isoporous graded film of multi-block copolymers, and results in thin selective film layer (i.e., a surface layer) having on the order of more than 10 14 nearly monodisperse mesopores/m 2 above a graded microporous layer.
• THF tetrahydrofuran
• Hybridization of the isoporous films via homopolymer or small molecule blending enables tuning of pore size, and can result in pure water flux, solute rejection characteristics, and water vapor transport rates (WVTRs).
• Tuning pore size is accomplished by the incorporation of small molecules, including but not limited to pentadecyl phenol, dodecyl phenol, 2-4'- (hydroxybenzeneazo) benzoic acid (HABA).
• 1,8-naphthalene-dimethanol 3-hydroxy-2-naphthoic acid, and 6-hydroxy-2-naphthoic acid
• inorganic and organic acids including but not limited to hydrofluoric acid, hydrochloric acid, nitric acid, formic acid, acetic acid, propionic acid, lower alkyl di-carboxylic acids
• bases including but not limited to pyridine, ammonia, ammonium hydroxide, sodium hydroxide, potassium hydroxide, amines, polyamines (triethylamine, triethanolamine), amides (acetamide, formamide); including, but not limited to glycerol and other polyols, quinones, hydroquinones, catechols, carbohydrate
• small polymers including but not limited to poly acrylic acid, polyvinylpyridine, polyethylene oxide, naturally-derived polymers (cellulose, chitosan, complex carbohydrates)
• Another application of the invention is as part of a sensor, e.g. chemical or biochemical detection and/or quantification. For example, activation of a particular response on the material: resistance, capacitance, color, upon interaction of a target species to the material.
• a sensor e.g. chemical or biochemical detection and/or quantification. For example, activation of a particular response on the material: resistance, capacitance, color, upon interaction of a target species to the material.
• the interaction of the target species with the material invokes a detectable change or response of the material (e.g. change in spectrophotometric profile of membrane), allowing the detection and/or quantification of the target species.
• the target species may be but is not limited to a molecule, biomolecule (e.g. protein), biological structure (e.g. specific cell type), pathogen, chemical structure (e.g. nanoparticle), moiety on a molecule, moiety on a biomolecule, moiety on a biological structure, or moiety on a chemical structure.
• the material is used in a process detecting an analyte of interest contacting a medium containing at least one analyte of interest with the material.
• the materials/films of the present invention include integration into textiles, or a sensor device.
• At least one of the membrane or support is coated or impregnated with at least one topical antibiotic.
• at least one topical antibiotic for example, neomycin, polymixin B, mupirocin, bacitracin, erythromycin, or sulfacetamide sodium.
• at least one of the membrane or support is coated or impregnated with at least one clotting agent.
• At least one of the membrane or support is coated or impregnated with at least one agent to promote healing.
• agents for example, vitamins, proteins, amino acids, enzymes, or drugs. More specifically, some examples include: aloe vera gel or extract, vitamin A, vitamin Bl, vitamin B3, glycine, choline salicylate, or collagen.
• At least one of the membrane or support is coated or impregnated with at least one time released drug.
• compounds for enabling time release or controlled release include: hydroxypropyl methylcellulose, poly(vinyl alcohol), poly(acrylic acid), or waxes.
• At least one of the membrane or support is coated or impregnated with at least one responsively released drug.
• a drug is released upon exposure to a particular protein or pathogen.
• At least one of the membrane or support is coated or impregnated with at least one antiseptic.
• at least one antiseptic for example, benzalkonium chloride, chlorhexidine, alexidine, povidone-iodine, benzethonium chloride, chloroxylenol, alcohols, or triclosan.
• At least one of the membrane or support is coated or impregnated with at least one anesthetic.
• anesthetic for example, benzocaine, lidocaine, tetracaine, pramoxine, phenol, menthol, prilocaine, or dyclonine.
• the invention includes an adhesive for affixing the bandage to the body.
• the adhesive is a pressure sensitive adhesive.
• at least one pressure sensitive adhesive polymer or block copolymers comprising, for example: poly(acrylates), poly(methacrylates), rubbers, poly(isoprene), poly(butadiene), poly(acrylates), poly(acrylic acid), poly(vinyl acetate), etc.
• the invention is used as a bandage for a burn.
• the invention is used as an oral bandage.
• the invention is used as a bandage for internal body use.
• the bandage is bioabsorbable after a certain period of time.
• the materials comprise bioabsorbable polymers or copolymers comprising polymers or polymer blocks such as: poly(lactic acid)s, poly(glycolic acid), polyesters, poly(caprolactone), poly(orthoester), poly(hydroxybutyrate valerate), poly(dioxanone), or poly(trimethylene carbonate).
• the bandage has a two-dimensional or three-dimensional geometric arrangement suitable for particular use or body part. For example, a contoured bandage to more appropriately fit a joint.
• At least one of the membrane or support is coated or impregnated with at least one inactive ingredient for storing, diluting, or delivering a coating or impregnation.
• at least one inactive ingredient for storing, diluting, or delivering a coating or impregnation.
• inactive ingredient for example, pure water, glycerol, petroleum jelly, or lanolin.
• At least one of the membrane or support is coated or impregnated with at least one antioxidant for stability and shelf life.
• at least one antioxidant for stability and shelf life.
• ascorbic acid for example, ascorbic acid, tocopherols, carotenoids, carotenes, or butylated hydroxytoluene.
• a portion of the bandage has an inlet, valve, or septum such that a substance can be introduced or extracted to or from the bandage or wound without necessitating removing the bandage.
• a drug can be injected from a syringe either with or without a needle without removing the bandage.
• a sample of bodily fluid can be extracted with a syringe, with or without a needle, from the bandage or wound without removing the bandage.
• the bandage is directly inserted into a wound as a packing.
• the bandage incorporates an indicator.
• Said indicator may indicate: a bandage needs changing, lack of moisture, excess moisture, presence of a pathogen, expenditure of drug or topical agent, wound coagulation, etc.
• the bandage is packaged with a hydrating agent or humectant to retain moisture on the membrane. For example, pure water, glycerol, or aloe vera gel.
• the bandage is packaged dry.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Engineering & Computer Science (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Chemical & Material Sciences (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Vascular Medicine (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Medicinal Chemistry (AREA)
• Epidemiology (AREA)
• Hematology (AREA)
• Materials Engineering (AREA)
• Biophysics (AREA)
• Physics & Mathematics (AREA)
• Dispersion Chemistry (AREA)
• Pathology (AREA)
• Medical Informatics (AREA)
• Molecular Biology (AREA)
• Surgery (AREA)
• Materials For Medical Uses (AREA)
• Finger-Pressure Massage (AREA)

Priority Applications (7)

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Publications (1)

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• 2017
  • 2017-11-21 CA CA3045012A patent/CA3045012A1/en active Pending
  • 2017-11-21 US US16/463,256 patent/US20190307610A1/en not_active Abandoned
  • 2017-11-21 EP EP17874473.6A patent/EP3544558B1/en active Active
  • 2017-11-21 MX MX2019006156A patent/MX2019006156A/es unknown
  • 2017-11-21 JP JP2019548866A patent/JP2020500678A/ja active Pending
  • 2017-11-21 KR KR1020197018623A patent/KR20190119574A/ko not_active Ceased
  • 2017-11-21 WO PCT/US2017/062681 patent/WO2018098108A1/en not_active Ceased
  • 2017-11-21 CN CN201780073476.XA patent/CN110475530A/zh active Pending

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