WO2018090848A1 - 一种健脾通络解毒的中药颗粒剂 - Google Patents

一种健脾通络解毒的中药颗粒剂 Download PDF

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WO2018090848A1
WO2018090848A1 PCT/CN2017/109618 CN2017109618W WO2018090848A1 WO 2018090848 A1 WO2018090848 A1 WO 2018090848A1 CN 2017109618 W CN2017109618 W CN 2017109618W WO 2018090848 A1 WO2018090848 A1 WO 2018090848A1
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granule
chinese medicine
traditional chinese
medicine granule
ethanol
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PCT/CN2017/109618
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English (en)
French (fr)
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谢海青
杨安平
冯志刚
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佛山科学技术学院
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
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    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Definitions

  • the invention relates to the field of medicine, in particular to a traditional Chinese medicine granule for relieving spleen and collaterals and detoxifying.
  • Herpes zoster is an acute infectious skin disease caused by varicella-zoster virus. Some patients become infected with a virus without symptoms. Because the virus is neurotropic, it can be lurking in the neurons of the posterior root ganglia of the spinal cord for a long time after infection. When the resistance is low or tired, infected, or caught, the virus can grow and reproduce and move along the nerve fibers to the skin. Causes intense inflammation of the affected nerves and skin. The rash is generally characterized by unilateral and neurite distribution, with clustered herpes and pain. It is often difficult for patients to endure the side effects of Western medicine in treatment. Moreover, in the course of diagnosis and treatment, some people with this disease are also diagnosed with other diseases, such as malignant tumors or diabetes, which makes the treatment of this disease more difficult.
  • Acne also known as pressure ulcer, pressure sore
  • pressure ulcer pressure sore
  • Skin acne is a common problem in rehabilitation and nursing, mostly for patients who are bedridden for a long time. Due to the heavy pressure and friction of the body, the skin of the superficial skin is damaged, and the sores are not cured. Chronic sore disease. According to relevant literature reports, about 60,000 people die each year from combined pressure ulcers.
  • the existing methods for treating acne mainly include: (1) Disinfection and dressing method: disinfecting and cleaning the patient's sore surface, uniformly covering the wound surface with ointment after cleaning, and wrapping with a sterile dressing to promote rapid proliferation of the wound, thereby accelerating wound healing. .
  • Infrared radiation treatment of hemorrhoids through the infrared irradiation of the sore face for 20 minutes, 3 to 4 times a day, can promote the rapid scarring of the sore surface.
  • Acne refers to chronic ulcers that occur in the lower part of the lower leg: also known as trousers poison, skirt sore, equivalent to Western medicine chronic leg ulcers.
  • the disease is often secondary to diseases such as venous varicose veins and erysipelas. Its clinical features are mostly in the anterior and inferior aspect of the lower third of the lower leg.
  • the affected part Before the ulcer occurs, the affected part has long-term skin ecchymosis and roughness. After the ulceration, the sore mouth is unhealed or Has closed, each easy to relapse due to local damage.
  • Hemorrhoids are often caused by long-term or heavy load, overworked, consuming blood, and the gas is sag, resulting in poor blood flow in the lower limbs, or formation of qi qi and blood stagnant in the skin, skin dystrophy, and complex damage ( Mosquito bites, wet sores, bruises, etc.), the evil of damp heat is taken by people, it is caused by sores, the skin is festering, and it is not cured for a long time.
  • the existing methods for treating acne mainly include: (1) the traditional method of opening a knife, commonly known as “crusting and peeling", which is complicated and time-consuming to treat diseased blood vessels, has many incisions, severe trauma, pain, long hospital stay, slow recovery, postoperative There are scars, unsightly, and many complications; (2) minimally invasive surgical methods: the main representative methods such as microwave endovascular treatment, by closing the lesion of the large (small) saphenous vein, varicose veins, traffic veins, to achieve Improve the venous return of the lower extremities, relieve the bleeding of the lower extremities, and treat the disease.
  • the traditional Chinese medicine for internal and external use with heat-clearing dampness and phlegm-reinforcing muscle can promote the healing of skin ulcers and obtain the effect of curing the disease.
  • the technical problem to be solved by the invention is to provide a traditional Chinese medicine granule for relieving spleen, collaterals and detoxification, which has simple drug composition, simple treatment method and quick effect, and can effectively treat herpes zoster and its post-herpetic neuralgia, hemorrhoids and phlegm simultaneously. Sores greatly reduce the suffering of patients.
  • the present invention provides a traditional Chinese medicine granule for relieving spleen, collaterals and detoxification, and the formula of the traditional Chinese medicine granule is:
  • Astragalus 20-40g Codonopsis 10-25g, Atractylodes 10-20g, raw licorice 1-10g, dry Pinellia 5-15g, dried tangerine peel 5-15g, Amomum villosum 5-15g, fragrant attached 7-18g, Nocturnal vine 20 -40g, ⁇ 1-3, Dilong 10-20g, Clematis 10-20g, Xuanhu 5-15g, Salvia 20-40g, Bupleurum 5-15g, Radix Isatidis 20-40g, Coix seed 20-40g, Qinglan 5-15g;
  • the traditional Chinese medicine granules are prepared by the following methods: weighing each raw material according to the formula, pulverizing and mixing uniformly; adding water to immerse the medicinal material, heating and boiling, separating the decoction liquid, filtering, evaporating the water boiling liquid, adding after cooling 1-2 times the amount of ethanol, place the precipitate, take the supernatant, the precipitate is washed with ethanol, the washing liquid and the filtrate are combined, the ethanol is recovered under reduced pressure, filtered, and the filtrate is evaporated to a thick paste at a low temperature to obtain an extract; After mixing the extract and the auxiliary material, the wetting agent is added to make the soft material; the soft material is made into a granule type by a pellet machine, and the package is sealed.
  • the formulation of the traditional Chinese medicine granule is:
  • Astragalus 25-35g Codonopsis 15-20g, Atractylodes 12-18g, raw licorice 3-8g, dry Pinellia 7-12g, dried tangerine peel 8-12g, Amomum 8-12g, fragrant attached 10-15g, night vine 25 -35g, ⁇ 2-3, Dilong 12-18g, Clematis 12-18g, Xuanhu 7-12g, Salvia 25-35g, Bupleurum 8-12g, Radix Isatidis 25-35g, Coix seed 25-35g, Qinglan 8-12g.
  • the formulation of the traditional Chinese medicine granule is:
  • Astragalus 30g Codonopsis pilosula 18g, Atractylodes 15g, raw licorice 6g, dry Pinellia 10g, dried tangerine peel 10g, Amomum villosum 10g, fragrant fragrant 12g, Nocturnal vine 30g, ⁇ 2, Dilong 15g, Clematis 15g, Xuanhu 10g, 30g of Salvia miltiorrhiza, 10g of Bupleurum, 30g of Radix Isatidis, 30g of Coix seed, 10g of barley.
  • the water boiling liquid is evaporated to a concentration specific gravity of 1:1.05.
  • the adjuvant is starch, dextrin and/or sucrose.
  • the temperature of the low temperature evaporation is 60 to 70 °C.
  • the wetting agent is 75-85% ethanol.
  • the step of forming the soft material into a granule form by using a granule machine comprises:
  • the soft material is made into a wet granule by a granule machine, and the moisture content of the wet granule is 7-10%;
  • the wet granules are dried into a granule form by a dryer, and the drying temperature of the dryer is 70-80 °C.
  • the main pathogenesis of herpes zoster is the virtual standard, which is spleen deficiency and blood stasis.
  • the invention has the functions of Codonopsis pilosula, Atractylodes chinensis, raw licorice, dried tangerine peel, dried pinellia sinensis, and scutellaria sinensis, and aims to strengthen the spleen and replenish qi, and stomach, nourish the heart and calm the nerves; cockroaches, earthworms, clematis, sinensis, danshen, firewood Hu, Ban GmbH Huoxue Tongluo detoxification and pain relief.
  • the invention has the functions of tonifying the spleen and activating blood circulation, clearing the collaterals and detoxifying, and putting the righting in the first place. Otherwise, it is the most detrimental to heat and detoxification, and it is most likely to damage the yang and suffer from abdominal pain, vomiting, dizziness, fatigue and limb discomfort, resulting in more pain for the patient. And can not adhere to treatment.
  • the invention consists only of the above-mentioned medicines, has simple composition, rich drug source and low price; the treatment method is simple, only need internal administration, and the burden on the patient is reduced. Moreover, the patient only needs to take 1 dose of the soup every day. After taking it for about 3 days, the pain is obviously relieved, and it takes about 7 days to heal, and the effect is quick.
  • the present invention is not only effective for patients with herpes zoster, but also, if the patient with herpes zoster has other diseases such as malignant tumor or diabetes, the present invention can also be effectively treated, and the side effects are small, and the pain of the patient is obviously alleviated. .
  • the present invention not only has curative effect on patients with herpes zoster, but also can effectively treat hemorrhoids and hemorrhoids.
  • hemorrhoids and hemorrhoids When treating hemorrhoids and hemorrhoids, he also takes 1 dose of soup every day, taking about 2-3 days, and his condition is obviously improved. It can be cured in about 5-7 days, with quick results and small side effects, which can significantly alleviate the suffering of patients.
  • the invention provides a traditional Chinese medicine granule for relieving spleen and collaterals and detoxifying, and the formula of the traditional Chinese medicine granule is:
  • Astragalus 20-40g Codonopsis 10-25g, Atractylodes 10-20g, raw licorice 1-10g, dry Pinellia 5-15g, dried tangerine peel 5-15g, Amomum villosum 5-15g, fragrant attached 7-18g, Nocturnal vine 20 -40g, ⁇ 1-3, Dilong 10-20g, Clematis 10-20g, Xuanhu 5-15g, Salvia 20-40g, Bupleurum 5-15g, Radix Isatidis 20-40g, Coix seed 20-40g, Qinglan 5-15g.
  • the traditional Chinese medicine granules are prepared by the following methods: weighing each raw material according to the formula, pulverizing and mixing uniformly; adding water to immerse the medicinal material, heating and boiling, separating the decoction liquid, filtering, evaporating the water boiling liquid, adding after cooling 1-2 times the amount of ethanol, place the precipitate, take the supernatant, the precipitate is washed with ethanol, the washing liquid and the filtrate are combined, the ethanol is recovered under reduced pressure, filtered, and the filtrate is evaporated to a thick paste at a low temperature to obtain an extract; After mixing the extract and the auxiliary material, the wetting agent is added to make the soft material; the soft material is made into a granule type by a pellet machine, and the package is sealed.
  • the formulation of the traditional Chinese medicine granules is preferably:
  • Astragalus 25-35g Codonopsis 15-20g, Atractylodes 12-18g, raw licorice 3-8g, dry Pinellia 7-12g, dried tangerine peel 8-12g, Amomum 8-12g, fragrant attached 10-15g, night vine 25 -35g, ⁇ 2-3, Dilong 12-18g, Clematis 12-18g, Xuanhu 7-12g, Salvia 25-35g, Bupleurum 8-12g, Radix Isatidis 25-35g, Coix seed 25-35g, Qinglan 8-12g.
  • the formula of the traditional Chinese medicine granule is:
  • Astragalus 30g Codonopsis pilosula 18g, Atractylodes 15g, raw licorice 6g, dry Pinellia 10g, dried tangerine peel 10g, Amomum villosum 10g, fragrant fragrant 12g, Nocturnal vine 30g, ⁇ 2, Dilong 15g, Clematis 15g, Xuanhu 10g, 30g of Salvia miltiorrhiza, 10g of Bupleurum, 30g of Radix Isatidis, 30g of Coix seed, 10g of barley.
  • Astragalus also known as Mian
  • Astragalus has enhanced immune function, liver protection, diuresis, anti-aging, anti-stress, antihypertensive and a wide range of antibacterial effects.
  • the facts of evil spirits, qi stagnation and dampness, food stagnation, sputum at the beginning or after the collapse of the hot poison Shangsheng and other evidence, as well as yin deficiency and impotence, must be banned.
  • Dangshen with the effect of supplementing the vital energy, strengthening the spleen and benefiting the lungs, can enhance immunity, dilate blood vessels, reduce blood pressure, improve microcirculation, and enhance hematopoietic function. In addition, it has an effect on the decline of white blood cells caused by chemotherapy and radiotherapy.
  • Atractylodes with spleen and qi, dampness and water, antiperspirant, anti-fetal effect, used for spleen deficiency, bloating, diarrhea, edema, edema, spontaneous sweating, fetal movement.
  • Medical Qiyuan records: "Dehumidification and dryness, and Zhongyiqi, Wenzhong, go to the spleen and stomach, except for stomach heat, strong spleen and stomach, into the diet, and fetus.”
  • Dry Pinellia alias old blind, water jade, geography, three-step jump, Ma Yu fruit, etc., tuber into the medicine, can dampness and phlegm, reduce vomiting, use sputum swelling; attend more cough, nausea and vomiting; External treatment of acute mastitis, acute and chronic suppurative otitis media.
  • Amomum nickname: Yangchun Amomum, Changtai Amomum (Fujian), also known as cardamom, attending spleen and stomach stagnation, food can not be saved, abdominal pain, swelling, vomiting, cold and cold.
  • liver qi stagnation, chest tightness, hypochondriac pain, stomach disease, abdominal pain; and irregular menstruation, dysmenorrhea and other diseases.
  • Night vines have the effect of nourishing the heart, calming the nerves, and collaterals.
  • insomnia more dreams, bloody body pain, skin numbness, rheumatism and pain, rubella itching.
  • Dilong has the effect of promoting vitality, promoting blood circulation and removing blood stasis, preventing and treating cardiovascular and cerebrovascular diseases. Indications of fever, convulsions, convulsions, cough, headache, red eyes, sore throat, urinary joint pain, rheumatism and joint pain, hemiplegia, strong heat and shock, convulsions, lung heat, cough, asthma, phlegm and swelling pain.
  • Clematis, roots and stems are used as medicines, which have the effects of rheumatism, meridians and collaterals.
  • Xuanhu also known as Yuanhu, Yanhusuo, has the effect of promoting blood circulation and relieving pain.
  • Salvia miltiorrhiza has the effect of promoting blood circulation, relieving pain, clearing heart and removing trouble, cooling blood and eliminating phlegm.
  • Bupleurum alias smoked, mountain vegetables, mushroom grass, firewood.
  • Ban GmbH alias: indigo root, blue dragon root, Daqing root, with the effect of clearing away heat and detoxification, cooling blood and pharynx.
  • indigo root blue dragon root
  • Daqing root Red Node
  • Coix seed sweet and slightly cold, is beneficial to water swelling, spleen and dampness, spleen and remove phlegm, clearing heat and purulent discharge, etc., is a commonly used water osmotic drug.
  • Qinglan with heat-clearing and detoxifying, cooling blood and spotting, diarrhea and stunning, etc., used for warm disease, rash, vomiting blood, hemoptysis, sore throat, convulsions, sore, erysipelas, snake bites, etc. .
  • the main pathogenesis of herpes zoster is the virtual standard, which is spleen deficiency and blood stasis.
  • the invention has the functions of Codonopsis pilosula, Atractylodes chinensis, raw licorice, dried tangerine peel, dried pinellia sinensis, and scutellaria sinensis, and aims to strengthen the spleen and replenish qi, and stomach, nourish the heart and calm the nerves; cockroaches, earthworms, clematis, sinensis, danshen, firewood Hu, Ban GmbH Huoxue Tongluo detoxification and pain relief.
  • the invention has the functions of tonifying the spleen and activating blood circulation, clearing the collaterals and detoxifying, and putting the righting in the first place. Otherwise, it is the most detrimental to heat and detoxification, and it is most likely to damage the yang and suffer from abdominal pain, vomiting, dizziness, fatigue and limb discomfort, resulting in more pain for the patient. And can not adhere to treatment.
  • the invention consists only of the above-mentioned medicines, has simple composition, rich drug source and low price; the treatment method is simple, only need internal administration, and the burden on the patient is reduced. Moreover, the patient only needs to take 1 dose of the soup every day. After taking it for about 3 days, the pain is obviously relieved, and it takes about 7 days to heal, and the effect is quick.
  • the present invention is not only effective for patients with herpes zoster, but also, if the patient with herpes zoster has other diseases such as malignant tumor or diabetes, the present invention can also be effectively treated, and the side effects are small, and the pain of the patient is obviously alleviated. .
  • the present invention not only has curative effect on patients with herpes zoster, but also can effectively treat hemorrhoids and hemorrhoids.
  • hemorrhoids and hemorrhoids When treating hemorrhoids and hemorrhoids, he also takes 1 dose of soup every day, taking about 2-3 days, and his condition is obviously improved. It can be cured in about 5-7 days, with quick results and small side effects, which can significantly alleviate the suffering of patients.
  • the water decoction liquid is evaporated to a concentration specific gravity of 1:1.05, which is beneficial to maintaining the efficacy and ensuring the therapeutic effect.
  • the adjuvant is starch, dextrin and/or sucrose, but is not limited thereto. It should be noted that the auxiliary material may also be selected according to the prior art, and the scope of implementation thereof is not limited to the embodiment of the present invention.
  • the low temperature evaporation temperature is 60-70 ° C, and the wetting agent is 75-85% ethanol, which is beneficial to improving the utilization rate of the traditional Chinese medicine, maintaining the drug effect, and being easy to absorb.
  • the step of forming the soft material into a granule form by using a granule machine comprises:
  • the soft material is made into a wet granule by a granule machine, and the moisture content of the wet granule is 7-10%;
  • the wet granules are dried into a granule form by a dryer, and the drying temperature of the dryer is 70-80 °C.
  • the utilization rate of the traditional Chinese medicine material can be improved, the dosage of the product is accurate, the absorption is convenient, and the effect is fast.
  • the present invention is further produced by specific embodiments below.
  • the filtrate is evaporated to a thick paste at low temperature, the temperature of low temperature evaporation is 60 ° C, the specific gravity of the thick paste is generally 1.30-1.40, which is obtained by heat measurement (80-90 ° C), and the extract is mixed;
  • the wetting agent is made into a soft material; the soft material is made into a wet granule by a granule machine, and the moisture content of the wet granule is 7%; the wet granule is dried into a granule type by a dryer, and the drying temperature of the dryer is 70 ° C, and the package is sealed. .
  • the temperature at low temperature is 65 ° C.
  • the specific gravity of the thick paste is generally measured by heat (80-90 ° C). ) is 1.30-1.40, the extract is obtained; after the extract is mixed with the auxiliary material, the wetting agent is added to make the soft material; the soft material is made into the wet granule by the granule machine, and the moisture content of the wet granule is 8%; It is dried into a granule form by a dryer, and the drying temperature of the dryer is 72 ° C, and the package is sealed.
  • the temperature at low temperature is 60 ° C.
  • the specific gravity of the thick paste is generally measured by heat (80-90 ° C). ) is 1.30-1.40, the extract is obtained; after the extract is mixed with the auxiliary material, the wetting agent is added to make the soft material; the soft material is made into the wet granule by the granule machine, and the moisture content of the wet granule is 9%; Drying into a granule form by a dryer, the drying temperature of the dryer is 75 ° C, sealed package.
  • the temperature at low temperature is 70 ° C.
  • the specific gravity of the thick paste is generally measured by heat (80-90 ° C). ) is 1.30-1.40, the extract is obtained; after the extract is mixed with the auxiliary material, the wetting agent is added to make the soft material; the soft material is made into the wet granule by the granule machine, and the moisture content of the wet granule is 10%; It is dried into a granule form by a dryer, and the drying temperature of the dryer is 80 ° C, and the package is sealed.
  • Patient A Female, 45 years old, with severe tingling in the left lower back. The next day, the patient developed clusters of soy-sized herpes and blisters, and was diagnosed with herpes zoster. After 10 days of treatment with acyclovir, vitamin B12, tramadol, etc., the patient still has pain, the left waist is still severely painful, unable to sleep normally, and urgently requires pain relief. It is necessary to be supported by others to walk barely (walking freely before the onset) With fatigue, self-sweating, nausea, anorexia, no stool on the 5th.
  • Patient B Female, 39 years old, with severe tingling around the neck and mouth. The next day, the patient developed clusters of soy-sized herpes and blisters, diagnosed with herpes zoster. After 10 days of treatment with acyclovir, vitamin B12, tramadol, etc., the patient is still suffering from pain, severe pain around the neck and mouth, unable to sleep normally, urgently requiring pain relief, and need to be supported by others to barely walk (before onset) Walking freely, with Shenpi fatigue, spontaneous sweating, nausea, anorexia, no stool on the 3rd. Physical examination: normal heart and lung, rash around the neck and mouth, bandages have been broken, the tongue is light, the tongue is fat, pale and greasy, and the pulse is weak. B-ultrasound showed no abnormalities in the kidneys, ureters, and bladder. Patient B also has breast tumors and hemorrhoids.
  • Patient C Male, 41 years old, with severe tingling around the waist and abdomen. The next day, the patient developed clusters of soybean-sized herpes and blisters, which were diagnosed as herpes zoster. After 10 days of treatment with acyclovir, vitamin B12, tramadol, etc., the patient still has pain Unbearable, the waist and abdomen are still severely painful, unable to sleep normally, urgently require pain relief, need to be supported by others to barely walk (free walking before the onset), accompanied by fatigue, spontaneous sweating, nausea, anorexia, no stool on the 7th.
  • Patient D Male, 56 years old, with severe tingling around the right waist. The next day, the patient developed clusters of soybean-sized herpes and blisters, which were diagnosed as herpes zoster. After 10 days of treatment with acyclovir, vitamin B12, tramadol, etc., the patient is still suffering from pain, the right waist is still severely painful, unable to sleep normally, and urgently requires pain relief. It is necessary to be supported by others to barely walk (walking freely before the onset) With fatigue, self-sweating, nausea, anorexia, no bowel movements on the 4th.
  • the present invention not only has curative effect on patients with herpes zoster, but also has less toxic and side effects, and significantly reduces the suffering of the patient. Moreover, if the patient with herpes zoster also suffers from other diseases, such as malignant tumors or diabetes, the present invention can also be effectively treated, and the side effects are small, which significantly reduces the suffering of the patient. In addition, the invention can also effectively treat hemorrhoids and hemorrhoids, has quick effect, can be cured after taking about 5-7 days, has quick effect, and has little toxic and side effects, and obviously reduces the suffering of the patient.

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Abstract

本发明公开了一种健脾通络解毒的中药颗粒剂，配方为：黄芪20-40g、党参10-25g、白术10-20g、生甘草1-10g、旱半夏5-15g、陈皮5-15g、砂仁5-15g、制香附7-18g、夜交藤20-40g、蜈蚣1-3条、地龙10-20g、威灵仙10-20g、玄胡5-15g、丹参20-40g、柴胡5-15g、板蓝根20-40g、薏仁20-40g、青黛5-15g；所述中药颗粒剂由下述方法制得：按配方称取各原料，制成颗粒剂型。本发明药物组成简单，治疗方法简单，见效快，可以同时有效治疗带状疱疹及其后遗神经痛、褥疮和臁疮，大大减轻病人痛苦。

Description

一种健脾通络解毒的中药颗粒剂 技术领域
本发明涉及医药领域，特别涉及一种健脾通络解毒的中药颗粒剂。
背景技术
带状疱疹是由水痘-带状疱疹病毒引起的急性感染性皮肤病。部分患者被感染后成为带病毒者而不发生症状。由于病毒具有亲神经性，感染后可长期潜伏于脊髓神经后根神经节的神经元内，当抵抗力低下或劳累、感染、感冒时，病毒可再次生长繁殖，并沿神经纤维移至皮肤，使受侵犯的神经和皮肤产生强烈的炎症。皮疹一般有单侧性和按神经节段分布的特点，有集簇性的疱疹组成，并伴有疼痛。病人在治疗上常常难以忍受西医的副反应。而且，患此病的人在诊治过程中，同时有一部分查出患有其他疾病，例如恶性肿瘤或糖尿病，这会让本病的治疗更为困难。
褥疮又称压力性溃疡、压疮，是由于局部组织长期受压，发生持续缺血、缺氧、营养不良而致组织溃烂坏死。皮肤褥疮在康复治疗、护理中是一个普通性的问题，多为长期卧床不起的患者，由于躯体的重压与摩擦而引起的，以局限性浅表皮肤破损，疮口经久不愈为主要表现的慢性疮疡类疾病。据有关文献报道，每年约有6万人死于压疮合并征。现有治疗褥疮的方法主要包括：(1)消毒包扎法：对患者的疮面进行消毒清洁，清洁后使用软膏均匀覆盖创面，用消毒敷料包扎，促进患者伤口快速的增生，从而加速创面的愈合。(2)高压氧治疗褥疮：用塑料袋罩住创面，向袋内送入纯氧，在这种环境下能够促进疮面愈合的效果。(3)红外线照射治疗褥疮：通过红外线照射疮面二十分钟，每天3到4次，能够促进疮面快速结疤。(4)传统中医药治疗：褥疮清湿敷治疗褥疮，每天湿敷3到4次，每次三十分钟。通过收湿敛疮、活血化瘀、调经通络、去腐生肌，快速、安全、全面的治疗褥疮。
臁疮是指发生在小腿下部的慢性溃疡：又称裤口毒、裙边疮，相当于西医的小腿慢性溃疡。本病多继发于恶脉(下肢静脉曲张)和丹毒等病。其临床特点是多发于小腿中下1/3交界处前内外侧，溃疡发生前患部长期皮肤瘀斑、粗糙，溃烂后疮口经久不愈或虽 已经收口，每易因局部损伤而复发。臁疮多因久立或负重远行，过度劳累，耗伤气血，中气下陷，以致下肢气血运行不畅，或形成恶脉气血瘀滞于肌肤，肌肤失养，复因损伤(蚊虫叮咬，湿疮，碰伤等)，湿热之邪乘虚而人，发为疮疡，肌肤溃烂，经久不愈。现有治疗臁疮的方法主要包括：(1)传统的开刀方法，俗称“抽筋剥皮”，处理病变血管复杂费时，开刀切口多、创伤重，痛苦大，患者住院时间长，恢复慢，术后有疤痕，不美观，并发症多；(2)微创手术方法：主要代表方法如微波血管腔内治疗术，通过闭合病变的大(小)隐静脉、曲张的属支静脉、交通静脉，达到改善下肢静脉回流、解除下肢瘀血、治疗此病的目的；同时术后配合清热利湿、祛腐生肌的中药内服、外用，能较快促进皮肤溃疡愈合，获得疾病治愈的效果。
发明内容
本发明所要解决的技术问题在于，提供一种健脾通络解毒的中药颗粒剂，药物组成简单，治疗方法简单，见效快，可以同时有效治疗带状疱疹及其后遗神经痛、褥疮和臁疮，大大减轻病人痛苦。
为达到上述技术效果，本发明提供了一种健脾通络解毒的中药颗粒剂，所述中药颗粒剂的配方为：
黄芪20-40g、党参10-25g、白术10-20g、生甘草1-10g、旱半夏5-15g、陈皮5-15g、砂仁5-15g、制香附7-18g、夜交藤20-40g、蜈蚣1-3条、地龙10-20g、威灵仙10-20g、玄胡5-15g、丹参20-40g、柴胡5-15g、板蓝根20-40g、薏仁20-40g、青黛5-15g；
所述中药颗粒剂由下述方法制得：按配方称取各原料，粉碎并混合均匀；加水浸没药材后加热煎煮，分离煎出液，滤过后，将水煎煮液蒸发，冷后加入1-2倍量乙醇，放置沉淀，取其上清液，沉淀物再用乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成颗粒剂型，密封包装。
作为上述方案的改进，所述中药颗粒剂的配方为：
黄芪25-35g、党参15-20g、白术12-18g、生甘草3-8g、旱半夏7-12g、陈皮8-12g、砂仁8-12g、制香附10-15g、夜交藤25-35g、蜈蚣2-3条、地龙12-18g、威灵仙12-18g、玄胡7-12g、丹参25-35g、柴胡8-12g、板蓝根25-35g、薏仁25-35g、青黛8-12g。
作为上述方案的改进，所述中药颗粒剂的配方为：
黄芪30g、党参18g、白术15g、生甘草6g、旱半夏10g、陈皮10g、砂仁10g、制香附12g、夜交藤30g、蜈蚣2条、地龙15g、威灵仙15g、玄胡10g、丹参30g、柴胡10g、板蓝根30g、薏仁30g、青黛10g。
作为上述方案的改进，所述的水煎煮液蒸发至浓度比重为1：1.05。
作为上述方案的改进，所述辅料为淀粉、糊精和/或蔗糖。
作为上述方案的改进，所述低温蒸发的温度为60-70℃。
作为上述方案的改进，所述润湿剂为75-85％乙醇。
作为上述方案的改进，将软材用颗粒机制成颗粒剂型的步骤包括：
将软材用颗粒机制成湿粒，湿粒的含水量为7-10％；
将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为70-80℃。
实施本发明具有如下有益效果：
带状疱疹的主要病机为本虚标实，虚实错杂，具体表现为脾虚血淤毒结。本发明党参、白术、生甘草、陈皮、旱半夏加黄芪、夜交藤，旨在健脾益气、和胃、养心安神；蜈蚣、地龙、威灵仙、玄胡、丹参、柴胡、板蓝根活血通络解毒止疼。本发明起健脾活血通络解毒的作用，把扶正放在首位，否则，一味清热解毒，最易损伤中阳而出现腹胀痛、呕吐、神疲懒言，四肢乏力等不适，导致患者更加痛苦而无法坚持治疗。本发明仅由上述药物组成，构成简单，药物来源丰富，价格低廉；治疗方法简单，只需要内服即可，减轻患者负担。而且，患者只需要每天服用1剂汤药，服用3天左右就明显减轻疼痛，服用7天左右即可痊愈，见效快。此外，本发明不单对带状疱疹患者有疗效，而且，若带状疱疹患者同时还患有其他疾病，如恶性肿瘤或糖尿病时，本发明也可以有效治疗，且毒副作用小，明显减轻患者痛苦。
进一步，本发明不单对带状疱疹患者有疗效，同时还可以有效治疗褥疮和臁疮，治疗褥疮和臁疮时，同样也是每天服用1剂汤药，服用2-3天左右，病情明显好转，服用5-7天左右即可痊愈，见效快，且毒副作用小，明显减轻患者痛苦。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明作进一步地详细描述。
本发明提供了一种健脾通络解毒的中药颗粒剂，所述中药颗粒剂的配方为：
黄芪20-40g、党参10-25g、白术10-20g、生甘草1-10g、旱半夏5-15g、陈皮5-15g、砂仁5-15g、制香附7-18g、夜交藤20-40g、蜈蚣1-3条、地龙10-20g、威灵仙10-20g、玄胡5-15g、丹参20-40g、柴胡5-15g、板蓝根20-40g、薏仁20-40g、青黛5-15g。
所述中药颗粒剂由下述方法制得：按配方称取各原料，粉碎并混合均匀；加水浸没药材后加热煎煮，分离煎出液，滤过后，将水煎煮液蒸发，冷后加入1-2倍量乙醇，放置沉淀，取其上清液，沉淀物再用乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成颗粒剂型，密封包装。
所述中药颗粒剂的配方优选为：
黄芪25-35g、党参15-20g、白术12-18g、生甘草3-8g、旱半夏7-12g、陈皮8-12g、砂仁8-12g、制香附10-15g、夜交藤25-35g、蜈蚣2-3条、地龙12-18g、威灵仙12-18g、玄胡7-12g、丹参25-35g、柴胡8-12g、板蓝根25-35g、薏仁25-35g、青黛8-12g。
更佳的，所述中药颗粒剂的配方为：
黄芪30g、党参18g、白术15g、生甘草6g、旱半夏10g、陈皮10g、砂仁10g、制香附12g、夜交藤30g、蜈蚣2条、地龙15g、威灵仙15g、玄胡10g、丹参30g、柴胡10g、板蓝根30g、薏仁30g、青黛10g。
其中，黄芪，又名绵芪，其有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。但表实邪盛，气滞湿阻，食积停滞，痈疽初起或溃后热毒尚盛等实证，以及阴虚阳亢者，均须禁服。
党参，具有补中益气，健脾益肺之功效，可以增强免疫力、扩张血管、降压、改善微循环、增强造血功能。此外对化疗放疗引起的白细胞下降有提升作用。
白术，具有健脾益气，燥湿利水，止汗，安胎的功效，用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。《医学启源》记载：“除湿益燥，和中益气，温中，去脾胃中湿，除胃热，强脾胃，进饮食，安胎。”
生甘草，别名美草、密甘(蜜甘)、密草、国老、粉草、甜草、甜根子、棒草，药用部位是根及根茎，有补中益气、清热解毒、祛痰止咳、缓急止痛、调和药性的作用。
旱半夏，别名老鸹眼、水玉、地文、三步跳、麻玉果等，块茎入药，能燥湿化痰，降逆止呕，生用消疖肿；主治咳嗽痰多、恶心呕吐；外用治急性乳腺炎、急慢性化脓性中耳炎。
陈皮，理气健脾，燥湿化痰，用于脘腹胀满，食少吐泻，咳嗽痰多。
砂仁，别称：阳春砂仁，长泰砂仁(福建)，又名小豆蔻，主治脾胃气滞，宿食不消，腹痛痞胀，噎膈呕吐，寒泻冷痢。
制香附，味辛、微苦、甘，性平，具有疏肝理气，调经止痛之效。主治肝气郁滞，胸闷胁痛，胃病，腹痛；以及月经不调，痛经等病症。
夜交藤，具有养心安神，祛风，通络之功效。用于失眠，多梦，血虚身痛，肌肤麻木，风湿痹痛，风疹瘙痒。
蜈蚣，具有祛风，定惊，攻毒，散结之效。治中风，惊痫，破伤风，百日咳，瘰疬，结核，癥积瘤块，疮疡肿毒，风癣，白秃，痔漏，烫伤。
地龙，具有通经活络、活血化瘀、预防治疗心脑血管疾病作用。主治热病惊狂、小儿惊风、咳喘、头痛目赤、咽喉肿痛、小便不通、风湿关节疼痛，半身不遂，壮热惊痫，动风抽搐，肺热痰咳气喘，热痹节肿赤痛。
威灵仙，根及茎入药，具有祛风湿、通经络、消骨梗之功效。
玄胡，又名元胡，延胡索，具有活血散瘀，行气止痛之效。
丹参，具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
柴胡，别名地熏、山菜、菇草、柴草。有和解表里，疏肝升阳之功效。用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱垂、月经不调。
板蓝根，别名：靛青根、蓝靛根、大青根，具有清热解毒，凉血利咽之功效。常用于温疫时毒，发热咽痛，温毒发斑，痄腮，烂喉丹痧，大头瘟疫，丹毒，痈肿。
薏仁，性味甘淡微寒，有利水消肿、健脾去湿、舒筋除痹、清热排脓等功效，为常用的利水渗湿药。
青黛，具清热解毒、凉血消斑，泻火定惊等作用，用于温病热盛，斑疹，吐血、咯血，咽痛口疮，小儿惊痫，疮肿，丹毒，蛇虫咬伤等。
带状疱疹的主要病机为本虚标实，虚实错杂，具体表现为脾虚血淤毒结。本发明党参、白术、生甘草、陈皮、旱半夏加黄芪、夜交藤，旨在健脾益气、和胃、养心安神；蜈蚣、地龙、威灵仙、玄胡、丹参、柴胡、板蓝根活血通络解毒止疼。本发明起健脾活血通络解毒的作用，把扶正放在首位，否则，一味清热解毒，最易损伤中阳而出现腹胀痛、呕吐、神疲懒言，四肢乏力等不适，导致患者更加痛苦而无法坚持治疗。
本发明仅由上述药物组成，构成简单，药物来源丰富，价格低廉；治疗方法简单，只需要内服即可，减轻患者负担。而且，患者只需要每天服用1剂汤药，服用3天左右就明显减轻疼痛，服用7天左右即可痊愈，见效快。此外，本发明不单对带状疱疹患者有疗效，而且，若带状疱疹患者同时还患有其他疾病，如恶性肿瘤或糖尿病时，本发明也可以有效治疗，且毒副作用小，明显减轻患者痛苦。
进一步，本发明不单对带状疱疹患者有疗效，同时还可以有效治疗褥疮和臁疮，治疗褥疮和臁疮时，同样也是每天服用1剂汤药，服用2-3天左右，病情明显好转，服用5-7天左右即可痊愈，见效快，且毒副作用小，明显减轻患者痛苦。
关于上述制备方法，所述水煎煮液蒸发至浓度比重为1：1.05，有利于保持药效，保证治疗效果。
所述辅料为淀粉、糊精和/或蔗糖，但不限于此。需要说明的是，所述辅料还可以参照现有技术选择，其实施范围并不局限于本发明所举实施例。
所述低温蒸发的温度为60-70℃，所述润湿剂为75-85％乙醇，有利于提高中药的利用率，保持药效，易于吸收。
其中，将软材用颗粒机制成颗粒剂型的步骤包括：
将软材用颗粒机制成湿粒，湿粒的含水量为7-10％；
将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为70-80℃。
采用本发明的中药颗粒剂的制备方法，可以提高中药材的利用率，使产品剂量准确，便于吸收，起效快。
下面以具体实施例进一步产生本发明
实施例1
(一)配方：黄芪30g、党参18g、白术15g、生甘草6g、旱半夏10g、陈皮10g、砂仁10g、制香附12g、夜交藤30g、蜈蚣2条、地龙15g、威灵仙15g、玄胡10g、丹参30g、柴胡10g、板蓝根30g、薏仁30g、青黛10g。
(二)制备方法：
按配方称取除砂仁外的各原料，粉碎并混合均匀；加水浸没药材，浸泡20-40min，加热煎煮10-20min，再将砂仁5-15g纳入，煎沸5～10min，分离煎出液，滤过后，将水煎煮液蒸发，所述水煎煮液蒸发至浓度比重为1：1.05，冷后加入1倍量乙醇，放置沉淀，取其上清液，沉淀物再用50％-60％乙醇洗净，洗液与滤液合并，减压回收乙醇后， 过滤，滤液低温蒸发至稠膏状，低温蒸发的温度为60℃，稠膏的比重一般热测(80-90℃)为1.30-1.40，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成湿粒，湿粒的含水量为7％；将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为70℃，密封包装。
实施例2
(一)配方：黄芪30g、党参20g、白术18g、生甘草8g、旱半夏12g、陈皮10g、砂仁10g、制香附12g、夜交藤30g、蜈蚣2条、地龙15g、威灵仙15g、玄胡10g、丹参30g、柴胡10g、板蓝根30g、薏仁35g、青黛12g。
(二)制备方法：
按配方称取除砂仁外的各原料，粉碎并混合均匀；加水浸没药材，浸泡20-40min，加热煎煮10-20min，再将砂仁5-15g纳入，煎沸5～10min，分离煎出液，滤过后，将水煎煮液蒸发，所述水煎煮液蒸发至浓度比重为1：1.05，冷后加入2倍量乙醇，放置沉淀，取其上清液，沉淀物再用50％-60％乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，低温蒸发的温度为65℃，稠膏的比重一般热测(80-90℃)为1.30-1.40，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成湿粒，湿粒的含水量为8％；将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为72℃，密封包装。
实施例3
(一)配方：黄芪20g、党参10g、白术10g、生甘草1g、旱半夏5g、陈皮5g、砂仁5g、制香附7g、夜交藤20g、蜈蚣1条、地龙10g、威灵仙10g、玄胡5g、丹参20g、柴胡5g、板蓝根20g、薏仁20g、青黛5g。
(二)制备方法：
按配方称取除砂仁外的各原料，粉碎并混合均匀；加水浸没药材，浸泡20-40min，加热煎煮10-20min，再将砂仁5-15g纳入，煎沸5～10min，分离煎出液，滤过后，将水煎煮液蒸发，所述水煎煮液蒸发至浓度比重为1：1.05，冷后加入1倍量乙醇，放置沉淀，取其上清液，沉淀物再用50％-60％乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，低温蒸发的温度为60℃，稠膏的比重一般热测(80-90℃)为1.30-1.40，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成湿粒，湿粒的含水量为9％；将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为 75℃，密封包装。
实施例4
(一)配方：黄芪40g、党参25g、白术20g、生甘草10g、旱半夏15g、陈皮15g、砂仁15g、制香附18g、夜交藤40g、蜈蚣3条、地龙20g、威灵仙20g、玄胡15g、丹参40g、柴胡15g、板蓝根40g、薏仁40g、青黛15g。
(二)制备方法：
按配方称取除砂仁外的各原料，粉碎并混合均匀；加水浸没药材，浸泡20-40min，加热煎煮10-20min，再将砂仁5-15g纳入，煎沸5～10min，分离煎出液，滤过后，将水煎煮液蒸发，所述水煎煮液蒸发至浓度比重为1：1.05，冷后加入2倍量乙醇，放置沉淀，取其上清液，沉淀物再用50％-60％乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，低温蒸发的温度为70℃，稠膏的比重一般热测(80-90℃)为1.30-1.40，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成湿粒，湿粒的含水量为10％；将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为80℃，密封包装。
以实施例1-4对病人进行治疗，具体如下：
病人A：女，45岁，左腰部剧烈刺痛，次日患者出现成簇的黄豆大小的丘疱疹和水疱，确诊为带状疱疹。经阿昔洛韦、维生素B12，曲马多等治疗10天，患者仍疼痛难忍，左腰部仍剧烈疼痛，无法正常睡眠，迫切要求止痛，需由他人搀扶才能勉强步行(发病前行走自如)，伴神疲乏力，自汗，恶心，纳差，5日无大便。查体：心肺正常，左腰部皮疹呈带状分布，水疱部分已破，舌质淡，舌体胖，苍白腻，脉沉无力。B超显示：双肾、输尿管、膀胱未见异常。病人A同时还患有褥疮、臁疮。
病人B：女，39岁，颈部和嘴巴周围剧烈刺痛，次日患者出现成簇的黄豆大小的丘疱疹和水疱，确诊为带状疱疹。经阿昔洛韦、维生素B12，曲马多等治疗10天，患者仍疼痛难忍，颈部和嘴巴周围仍剧烈疼痛，无法正常睡眠，迫切要求止痛，需由他人搀扶才能勉强步行(发病前行走自如)，伴神疲乏力，自汗，恶心，纳差，3日无大便。查体：心肺正常，颈部和嘴巴周围皮疹呈带状分布，水疱部分已破，舌质淡，舌体胖，苍白腻，脉沉无力。B超显示：双肾、输尿管、膀胱未见异常。病人B同时还患有乳腺肿瘤、臁疮。
病人C：男，41岁，腰腹部周围剧烈刺痛，次日患者出现成簇的黄豆大小的丘疱疹和水疱，确诊为带状疱疹。经阿昔洛韦、维生素B12，曲马多等治疗10天，患者仍疼痛 难忍，腰腹部仍剧烈疼痛，无法正常睡眠，迫切要求止痛，需由他人搀扶才能勉强步行(发病前行走自如)，伴神疲乏力，自汗，恶心，纳差，7日无大便。查体：心肺正常，腰腹部皮疹呈带状分布，水疱部分已破，舌质淡，舌体胖，苍白腻，脉沉无力。B超显示：双肾、输尿管、膀胱未见异常。病人C同时还患有褥疮。
病人D：男，56岁，右腰部周围剧烈刺痛，次日患者出现成簇的黄豆大小的丘疱疹和水疱，确诊为带状疱疹。经阿昔洛韦、维生素B12，曲马多等治疗10天，患者仍疼痛难忍，右腰部仍剧烈疼痛，无法正常睡眠，迫切要求止痛，需由他人搀扶才能勉强步行(发病前行走自如)，伴神疲乏力，自汗，恶心，纳差，4日无大便。查体：心肺正常，右腰部皮疹呈带状分布，水疱部分已破，舌质淡，舌体胖，苍白腻，脉沉无力。B超显示：双肾、输尿管、膀胱未见异常。病人D同时还患有糖尿病。
将实施例1-4的药物分别给病人A、B、C、D予以治疗，结果如下：
Figure PCTCN2017109618-appb-000001
Figure PCTCN2017109618-appb-000002
由上可知，本发明不单对带状疱疹患者有疗效，毒副作用小，明显减轻患者痛苦。而且，若带状疱疹患者同时还患有其他疾病，如恶性肿瘤或糖尿病时，本发明也可以有效治疗，且毒副作用小，明显减轻患者痛苦。此外，本发明还可以有效治疗褥疮和臁疮，见效快，服用5-7天左右即可痊愈，见效快，且毒副作用小，明显减轻患者痛苦。最后 所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。

Claims (8)

  1. 一种健脾通络解毒的中药颗粒剂，其特征在于，所述中药颗粒剂的配方为：
    黄芪20-40g、党参10-25g、白术10-20g、生甘草1-10g、旱半夏5-15g、陈皮5-15g、砂仁5-15g、制香附7-18g、夜交藤20-40g、蜈蚣1-3条、地龙10-20g、威灵仙10-20g、玄胡5-15g、丹参20-40g、柴胡5-15g、板蓝根20-40g、薏仁20-40g、青黛5-15g；
    所述中药颗粒剂由下述方法制得：按配方称取各原料，粉碎并混合均匀；加水浸没药材后加热煎煮，分离煎出液，滤过后，将水煎煮液蒸发，冷后加入1-2倍量乙醇，放置沉淀，取其上清液，沉淀物再用乙醇洗净，洗液与滤液合并，减压回收乙醇后，过滤，滤液低温蒸发至稠膏状，得到浸膏；将浸膏与辅料混匀后，加润湿剂制成软材；将软材用颗粒机制成颗粒剂型，密封包装。
  2. 如权利要求1所述的中药颗粒剂，其特征在于，所述中药颗粒剂的配方为：
    黄芪25-35g、党参15-20g、白术12-18g、生甘草3-8g、旱半夏7-12g、陈皮8-12g、砂仁8-12g、制香附10-15g、夜交藤25-35g、蜈蚣2-3条、地龙12-18g、威灵仙12-18g、玄胡7-12g、丹参25-35g、柴胡8-12g、板蓝根25-35g、薏仁25-35g、青黛8-12g。
  3. 如权利要求2所述的中药颗粒剂，其特征在于，所述中药颗粒剂的配方为：
    黄芪30g、党参18g、白术15g、生甘草6g、旱半夏10g、陈皮10g、砂仁10g、制香附12g、夜交藤30g、蜈蚣2条、地龙15g、威灵仙15g、玄胡10g、丹参30g、柴胡10g、板蓝根30g、薏仁30g、青黛10g。
  4. 如权利要求1所述的中药颗粒剂，其特征在于，所述的水煎煮液蒸发至浓度比重为1：1.05。
  5. 如权利要求1所述的中药颗粒剂，其特征在于，所述辅料为淀粉、糊精和/或蔗糖。
  6. 如权利要求1所述的中药颗粒剂，其特征在于，所述低温蒸发的温度为60-70℃。
  7. 如权利要求1所述的中药颗粒剂，其特征在于，所述润湿剂为75-85％乙醇。
  8. 如权利要求1所述的中药颗粒剂，其特征在于，将软材用颗粒机制成颗粒剂型的步骤包括：
    将软材用颗粒机制成湿粒，湿粒的含水量为7-10％；
    将湿粒通过干燥机干燥成颗粒剂型，干燥机的烘干温度为70-80℃。
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