WO2018088286A1 - Détecteur de concentration de composant - Google Patents

Détecteur de concentration de composant Download PDF

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Publication number
WO2018088286A1
WO2018088286A1 PCT/JP2017/039480 JP2017039480W WO2018088286A1 WO 2018088286 A1 WO2018088286 A1 WO 2018088286A1 JP 2017039480 W JP2017039480 W JP 2017039480W WO 2018088286 A1 WO2018088286 A1 WO 2018088286A1
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WO
WIPO (PCT)
Prior art keywords
light
liquid
unit
component concentration
cell
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Application number
PCT/JP2017/039480
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English (en)
Japanese (ja)
Inventor
主 丹羽
千草 井中
敏司 大西
Original Assignee
東レエンジニアリング株式会社
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Publication of WO2018088286A1 publication Critical patent/WO2018088286A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity

Definitions

  • the present invention relates to a component concentration detector used when light is irradiated onto a liquid and the concentration of the component in the liquid is measured from the degree of light absorption.
  • ⁇ Patients with renal failure are treated with hemodialysis using a hemodialyzer that artificially replaces kidney function.
  • a dialyzer which is a blood purification apparatus is provided in a blood circulation path, and a dialysate circuit for supplying dialysate to the dialyzer is provided.
  • the blood collected from the patient undergoes extracorporeal circulation that is returned to the body via the dialyzer, and the blood is dialyzed by the dialysate supplied to the dialyzer through the semipermeable membrane of the dialyzer during the extracorporeal circulation. It is designed to remove waste and excess water inside.
  • the hemodialyzer is provided with a component concentration detector so that the concentrations of urea, uric acid, etc., which are waste products contained in the dialysate, can be measured. That is, by measuring the concentration change of this waste product, it is possible to grasp the patient's state during dialysis.
  • This component concentration detector is formed so that a change in concentration can be measured by detecting the absorbance of the drainage from the dialyzer. That is, it has a liquid cell part that circulates drainage (also simply referred to as liquid), an irradiation part that irradiates light to the liquid cell part, and a light receiving part that receives light from the irradiation part that has passed through the liquid cell part. The light concentration after the light absorption of the liquid passing through the liquid cell part is detected by the light receiving part.
  • the component concentration detector 100 is provided with a liquid cell portion 101 so as to block a through portion in a frame 105 having a through hole 104, and at one end portion of the through hole 104.
  • the irradiation unit 102 is provided, and the light receiving unit 103 is provided at the other end.
  • the light irradiated from the irradiation unit 102 passes through the liquid cell unit 101 through the through hole 104 and is received by the light receiving unit 103.
  • the liquid cell part 101 is formed such that two corrosion-resistant disc members 106 have a gap 107 (liquid cell part 101), and drainage (liquid) flows through the gap 107.
  • the disk member 106 is formed in a planar shape perpendicular to the irradiation direction so as not to obstruct the progression of light from the irradiation unit 102 as much as possible.
  • the gap 107 formed by the disk member 106 is formed so narrow that the received light intensity at the light receiving portion 103 does not become unnecessarily small as a result of the liquid flowing through the gap 107 absorbing light (for example, Patent Document 1).
  • the component concentration detector 100 may not be able to detect the component concentration with high accuracy. That is, since the gap 107 (liquid cell portion 101) through which the liquid flows is formed narrow, liquid stagnation and cavitation are likely to occur in the flow path, which may affect the liquid component concentration detection accuracy. is there.
  • the component concentration detector 100 since it is necessary to assemble the two disk members 106 in a state where the minute gap 107 is formed, the number of parts is increased and the structure is complicated, so the component concentration detector 100 itself. There was a problem that the cost of the would become high.
  • the present invention has been made in view of the above problems, and an object of the present invention is to provide a component concentration detector that can maintain the component concentration detection accuracy of a liquid and can reduce the cost of the device. Yes.
  • a component concentration detector of the present invention is a component concentration detector that irradiates a liquid with light and detects the component concentration in the liquid from the degree of light absorption, and irradiates the light.
  • a light receiving portion that receives light emitted from the irradiation portion, a liquid cell portion that is disposed between the irradiation portion and the light receiving portion, and in which a liquid flows, and light emitted from the irradiation portion is the liquid
  • a condensing part that condenses the light that has passed through the liquid in the cell part.
  • the light collecting unit that collects the light that has passed through the liquid cell unit since the light collecting unit that collects the light that has passed through the liquid cell unit is provided, the light input to the light receiving unit is concentrated, and the light receiving intensity required for the light receiving unit is increased. Can be maintained. That is, if the liquid cell unit increases the flow rate of the liquid by increasing the flow path of the liquid cell unit in order to prevent liquid stagnation or cavitation, the light accompanying the increase in the size of the flow path and the increase in the flow rate. Absorption increases. As a result, if the irradiated light is received by the light receiving unit as it is, the light receiving intensity of the light received by the light receiving unit will be weak and the liquid component concentration detection accuracy may not be maintained high.
  • the light receiving intensity of the light received by the light receiving unit can be amplified.
  • the light emitted from the irradiation unit is irradiated with a predetermined spread, and the liquid cell portion formed in a plane perpendicular to the irradiation direction receives the light as it travels while spreading. There is a risk that the amount of light will be lost as much as it falls off the part.
  • the light receiving intensity in the light receiving portion can be amplified.
  • the light receiving part can be formed small, and can be received even if there is a slight misalignment in the arrangement of the light receiving part, The configuration of the light receiving unit can be facilitated, and a design such as arrangement can be given a margin.
  • the flow path can be enlarged and the flow rate can be increased, and the structure of the liquid cell part can be made easy, the cost of the entire component concentration detector can be reduced.
  • liquid cell part by using a cylindrical tube for the liquid cell part, the liquid cell part and the light condensing part can be integrated.
  • the lens effect is caused by the curved surface of the cylindrical tube, the light that has passed through the liquid in the liquid cell portion can be collected and input to the light receiving portion. Therefore, it is not necessary to provide a separate member such as a lens between the liquid cell portion and the light receiving portion, and furthermore, a cylindrical tube made of glass or the like can be used for the liquid cell portion, thereby reducing the cost of the device itself. Can do.
  • the cylindrical tube may be made of quartz.
  • the light irradiated from the irradiation unit is UV light
  • the irradiation unit, the light receiving unit, the liquid cell unit, and a housing unit in which the condensing unit is accommodated The liquid cell unit is fixed to a cell frame unit, and the cell frame
  • the body part is detachably formed on the housing part, and in a state where the cell frame body part is attached to the housing part, the liquid cell part receives light emitted from the irradiation part. It may be configured to be positioned at a position where the liquid passes.
  • the liquid cell part can be positioned simply by attaching the cell frame part to the housing part, the replacement work of the liquid cell part becomes easy and the maintainability can be improved.
  • the liquid cell part is provided with a joint part connected to the pipe, and when the liquid cell part is inserted into the joint part, the liquid cell part is interposed between the joint part and the liquid cell part.
  • the liquid cell portion may be pressed and fixed when the sealing member receives pressure from the joint portion.
  • the liquid cell part is fixed simply by being inserted into the joint part. That is, when a general-purpose cylindrical member such as a glass tube or a quartz tube is used for the liquid cell portion, the cylindrical member can be fixed without performing special processing for attachment.
  • a general-purpose cylindrical member such as a glass tube or a quartz tube
  • the cost can be reduced as compared with the case of using an LED lamp.
  • the light receiving part may be further arranged on the opposite side of the cell frame part of the housing part.
  • the light receiving unit is further arranged on the opposite side of the cell frame body, that is, on the irradiation unit side, so that the light receiving unit can be used for monitoring the light amount of the irradiation unit.
  • the component concentration detection accuracy of the liquid can be maintained, and the cost of the device can be reduced.
  • FIG. 1 is a route diagram showing a hemodialysis apparatus to which a component concentration detector of the present invention is applied. It is a figure which shows the said component density
  • FIG. 4 is a sectional view taken along line AA in FIG. 3. It is a figure which shows a coupling part. It is a figure which shows the path
  • FIG. 1 is a route diagram showing a hemodialysis apparatus using a component concentration detector according to an embodiment of the present invention.
  • a hemodialysis apparatus 1 includes a blood circulation path section 2 that circulates patient's blood extracorporeally, a dialyzer 3 that is provided in the middle of the blood circulation path section 2, and purifies blood. It has a component concentration detector 4 that detects the concentration, and a dialysate path section 5 that circulates while supplying the dialysate to the dialyzer 3.
  • the blood circulation path part 2 is formed of a flexible tube, and has an outward path part 21 for circulating the blood collected from the patient and a return path part 22 for returning the purified blood to the patient.
  • the forward path path portion 21 and the return path path section 22 connect the patient and the dialyzer 3, and blood collected from the patient passes through the dialyzer 3 through the forward path path portion 21 by driving a pump (not shown).
  • the blood purified by the dialyzer 3 returns to the patient through the return path section 22.
  • the dialyzer 3 purifies the supplied blood and gradually waters, and has an inlet port 31 and an outlet port 32. That is, when the forward path portion 21 is connected to the inlet port 31 and the backward route portion 22 is connected to the outlet port 32, the patient's blood is supplied to the dialyzer 3 through the inlet port 31 and purified by the dialyzer 3. Blood is returned to the patient through outlet port 32.
  • a plurality of hollow fibers are accommodated in a container body 33, and blood passes through the hollow fibers.
  • the hollow fiber has a small through hole, and when blood passes through the hollow fiber, waste and excess water are permeated into the dialysate filled in the container body 33 through the through hole so that the blood is purified. It has become.
  • the dialysate path section 5 is formed of a flexible tube, and is formed by a supply line 51 for supplying dialysate and a drain line 52 for discharging dialysate after dialysis. That is, the dialyzer 3 has a supply port 34 to which the dialysate is supplied and a drain port 35 for discharging the dialysate.
  • the supply line 51 is connected to the supply port 34, and the drain line 52. And the drainage port 35 are connected. Accordingly, the dialysate is supplied from the dialysate supply source (not shown) to the dialyzer 3 through the supply line 51, dialyzed in the container body 33 of the dialyzer 3, and then used through the drainage line 52.
  • the dialysate is discharged as drainage (liquid of the present invention).
  • the component concentration detector 4 is provided in the drainage line 52.
  • the component concentration detector 4 is for detecting the component concentration of the liquid flowing through the drainage line 52 in real time.
  • This component concentration detector 4 irradiates the liquid flowing through the drainage line 52 with light, and detects the component concentration in the liquid from the light absorption degree of the light.
  • the component concentration detector 4 of this embodiment is connected to a monitoring device 6, and the monitoring device 6 monitors the detection result detected by the component concentration detector 4 and adjusts various settings of the component concentration detector 4. It has become so.
  • the component concentration detector 4 has a cell unit portion 7, a lamp unit portion 8, and a drainage monitor portion 9 in a housing portion 43 having an inlet portion 41 and an outlet portion 42.
  • FIG. 2A is a diagram showing an appearance of the component concentration detector 4
  • FIG. 2B is a diagram showing a state in which the cover part of the housing part 43 is removed.
  • the housing part 43 is a box-shaped case member.
  • the cell unit part 7 is accommodated in the central part thereof, and the lamp unit part 8 and the drainage monitor part 9 are accommodated so as to sandwich the cell unit part 7. ing. That is, the liquid flowing through the cell unit 7 is irradiated with UV light from the lamp unit 8, and the UV light that has passed through the liquid is received by the drainage monitor unit 9 so that the component concentration in the liquid is detected. It has become.
  • the cell unit portion 7 circulates the liquid in the drainage line 52 and includes an inlet portion 41 and an outlet portion 42 connected to the drainage line 52. That is, the inlet 41 is connected to the upstream side of the drainage line 52 and the outlet 42 is connected to the downstream side of the drainage line 52, so that the liquid discharged from the dialyzer 3 passes through the inlet 41. 7 and flows from the outlet 42 to the drainage line 52 again.
  • the cell unit section 7 includes a liquid cell section 71 through which a liquid flows and a cell frame body section 72 that supports the liquid cell section 71.
  • the cell frame 72 has a main body 72a that extends linearly, and support portions 72b that extend from both ends of the main body 72a in directions orthogonal to each other. It has a so-called U-shaped cross section.
  • Both support portions 72b are portions that support the liquid cell portion 71, and support both end portions of the liquid cell portion 71 extending in one direction. That is, the support portion 72b can support the liquid cell portion 71 at a position away from the main body portion 72a by a predetermined distance.
  • the liquid cell portion 71 When the cell unit portion 7 is accommodated in the housing portion 43, the liquid cell portion 71 is It is disposed between the lamp unit unit 8 and the drainage monitor unit 9 and is supported so that the liquid cell unit 71 is included in the irradiation region of the UV light from the lamp unit unit 8.
  • the cell unit portion 7 is detachably formed with respect to the housing portion 43.
  • the cell frame 72 can be attached to and detached from the housing 43. That is, the cell frame 72 can be fastened with the screw 73.
  • the cell frame 72 is removed as shown in FIG.
  • the cell frame portion 72 is arranged between the lamp unit portion 8 and the drainage monitor portion 9 and fastened with a screw 73 to be fixed to the housing portion 43.
  • the notch 44 is formed in the housing 43, and when the cell frame is disposed, the end of the main body 72 a of the cell frame has a minute gap in the notch 44. It comes to fit in.
  • the cell frame body portion 72 is positioned and fixed with respect to the housing portion 43 by fastening the screw while pressing against the notch portion 44 side. That is, in the state where the cell frame body part 72 is positioned in the housing part 43, as described above, the liquid cell part 71 is held in a state included in the irradiation region of the UV light from the lamp unit part 8, and the liquid cell part The axial direction of 71 and the axial direction of the lamp unit 8 (cold cathode tube UV lamp 81a) are fixed in parallel. Thereby, even when the cell frame body part 72 is removed, it is possible to easily return to the arrangement state of the liquid cell part 71 before the attachment / detachment by simply attaching the cell frame body part 72 to the housing part 43. .
  • the lamp unit unit 8 irradiates the liquid cell unit 71 with light.
  • the lamp unit portion 8 is provided at a position adjacent to the cell unit portion 7.
  • the lamp unit 8 is provided with an irradiation unit 81, and in this embodiment, a cold cathode tube UV lamp 81a is provided.
  • the cold-cathode tube UV lamp 81a is supported by a lamp support 82, and the cold-cathode tube UV lamp 81a extends in the direction (axis).
  • Direction is fixed along the direction (axial direction) in which the liquid cell portion 71 extends.
  • the cold-cathode tube UV lamp 81 a is fixed by the lamp support 82 at both ends thereof, and is supported so as to cover the portion that irradiates light with the curved portion 83.
  • An opening 84 is formed in the portion of the lamp support portion 72b facing the liquid cell portion 71 so that light from the cold cathode tube UV lamp 81a (irradiation portion 81) is irradiated from the opening 84. It has become. That is, the cold-cathode tube UV lamp 81a is irradiated with light over the entire surface of the cylindrical tube, but the light irradiated from the portion not facing the opening 84 is reflected by the curved portion 83 and the opening. By irradiating from 84, the light irradiated from the cold-cathode tube UV lamp 81a is efficiently irradiated to the liquid cell unit 71.
  • a drainage monitor unit 9 is provided at a position facing the lamp unit unit 8 across the liquid cell unit 71.
  • the drainage monitor unit 9 receives light emitted from the cold cathode tube UV lamp 81a and passed through the liquid cell unit 71.
  • the drainage monitor unit 9 is provided with a light receiving unit 91, and the light receiving unit 91 is provided with a photodiode.
  • the light receiving unit 91 is disposed on an extension of the irradiation direction of the cold cathode tube UV lamp 81a.
  • the center of the cold cathode tube UV lamp 81a, the center of the liquid cell unit 71, a photodiode (light receiving unit). 91) are arranged at positions where the centers thereof are aligned.
  • the light-receiving surface of the light-receiving part 91 is formed so as to face along the irradiation range in the longitudinal direction of the cold cathode tube UV lamp 81a. Thereby, the light received from the cold cathode tube UV lamp 81a and passed through the liquid cell part 71 can be received by the light receiving part 91 without waste.
  • the lamp unit 8 described above is also provided with a light receiving part (referred to as a second light receiving part 85).
  • the second light receiving unit 85 monitors the light output state of the cold cathode tube UV lamp 81 a of the lamp unit 8.
  • a second opening 86 is formed on the opposite side of the lamp support 72 b from the opening 84, and the second light receiving unit 85 is provided so as to face the second opening 86. It has been. As a result, the light from the cold-cathode tube UV lamp 81 a that is the irradiation unit 81 is directly received by the second light receiving unit 85.
  • the second light receiving part is attached to the housing part 43 side, and the electrical wiring connected to the second light receiving part does not hinder operability when the cell frame part 72 is removed. It is like that.
  • the light quantity value received by the second light receiving unit 85 is used as a reference value for the cold cathode tube UV lamp 81a. That is, the light emitted from the cold-cathode tube UV lamp 81a passes through the liquid that passes through the liquid cell unit 71 and is received by the light receiving unit 91, so that the component concentration is detected from the amount of light absorbed in the liquid.
  • the amount of light absorbed by the liquid is accurately determined based on the amount of light received by the second light receiving unit 85. Can be calculated well.
  • the lifetime of the cold cathode tube UV lamp 81a can also be monitored by providing a threshold value for the light quantity value obtained from the second light receiving unit 85.
  • a cylindrical tube is used for the liquid cell portion 71 through which the liquid flows.
  • the liquid cell portion 71 has a shape extending in one direction, and both end portions are supported by the support portions 72 b of the cell frame body portion 72. That is, the cylindrical tube is supported in a state in which the extending direction of the cylindrical tube coincides with the extending direction of the cold cathode tube UV lamp 81a, and the light irradiation direction (the direction irradiated from the irradiation unit 81 to the light receiving unit 91).
  • the cylindrical tube is supported in a state orthogonal to the axial direction of the cylindrical tube. That is, the cylindrical tube is supported in a state where the outer peripheral surface of the cylindrical tube faces the light source of the irradiation unit 81.
  • This cylindrical tube is made of quartz. That is, if a resin tube or the like is used for the liquid cell portion 71, the UV light of the cold cathode tube UV lamp 81a is absorbed by the resin tube, so the amount of light received by the light receiving portion 91 is an error corresponding to the amount absorbed by the resin tube. However, by using quartz, the UV light of the cold cathode tube UV lamp 81a used in the irradiation unit 81 is suppressed as much as possible from being absorbed by the liquid cell unit 71, and the liquid flowing in the cylindrical tube is reduced. The amount of light absorbed can be detected with high accuracy.
  • a light collecting unit 10 that collects light that has passed through the liquid is provided between the liquid flowing through the liquid cell unit 71 and the light receiving unit 91.
  • the liquid cell unit 71 and the light collecting unit 10 are provided integrally. That is, in this embodiment, since the cylindrical tube is provided in the liquid cell unit 71, the outer peripheral surface of the cylindrical tube serves as a lens (condensing unit 10), and collects light that has passed through the liquid to receive light.
  • the part 91 can be irradiated. Specifically, as shown in FIG.
  • the light irradiated from the irradiation unit 81 is refracted by the curved outer peripheral surface 71 a forming the cylindrical tube, and passes through the liquid in the cylindrical tube of the liquid cell unit 71. Thereafter, the light is condensed and travels closer to the center of the irradiated light than immediately after passing through the liquid.
  • the light receiving unit 91 amplifies the received light intensity as compared with the case where there is no light collecting effect, so that the wavelength band absorbed by the liquid clearly appears, and the liquid component concentration detection accuracy can be improved.
  • FIG. 6 shows the light of the case where the condensing part 10 is not used (when a parallel plate (liquid cell part formed in a plane perpendicular to the irradiation direction) is used instead of the cylindrical tube). It shows the course. In this case, since the light travels with the spread of the light emitted from the irradiation unit 81, the light receiving unit 91 cannot receive the light and loses the amount of light, which may reduce the liquid component concentration detection accuracy.
  • the liquid cell part 71 is connected to the inlet part 41 and the outlet part 42.
  • the inlet portion 41 and the outlet portion 42 have the same structure. Specifically, as shown in FIG. 5, the inlet portion 41 seals the joint portion 45 that covers the cylindrical tube (liquid cell portion 71) protruding from the housing portion 43, and the gap between the joint portion 45 and the cylindrical tube.
  • the seal member 46 is formed.
  • the joint portion 45 has a pipe connection portion 45 a connected to the upstream drain line 52 and a joint opening portion 45 b connected to the liquid cell portion 71, and the flange portion 45 c is connected to the housing portion 43. It is fixed by being fastened with a screw 45d.
  • the joint opening 45b is formed in a tapered shape that becomes narrower toward the pipe connecting portion 45a.
  • the seal member 46 is pressed and fixed. That is, in the liquid cell portion 71 (cylindrical tube) protruding from the housing portion 43, the first collar 47, the seal member 46 (O-ring), and the second collar 48 are disposed in this order from the housing portion 43 side.
  • the joint opening 45b is fitted and fixed. That is, when the joint portion 45 is screwed to the housing portion 43, the joint portion 45 is further fastened with the screw 45d after the taper portion of the joint opening 45b comes into contact with the seal member 46. Is pressed.
  • the seal member 46 pressed by the tapered portion expands and comes into close contact with the cylindrical tube and the tapered portion to form a cylinder.
  • the tube and the joint portion 45 are sealed. That is, the liquid that has entered the pipe connection part 45a from the drain line 52 flows into the cylindrical pipe without leaking from the joint opening 45b, and flows out from the outlet part 42 to the drain line 52 again.
  • the joint portion 45 With such a configuration of the joint portion 45, it can be used as the liquid cell portion 71 without any processing into a cylindrical tube, and has a cheaper configuration than the conventional liquid cell portion 71 having a complicated configuration. can do.
  • the light collecting unit 10 that condenses the light that has passed through the liquid cell unit 71 is provided.
  • the light receiving intensity required for the part 91 can be maintained. That is, in a member in which the surface of the irradiated liquid cell part 71 is formed as a flat surface as in the prior art, the irradiated light is received by the light receiving part 91 as it is, and therefore the amount of light absorption in the liquid cell part 71 increases.
  • the light receiving intensity of the light received by the light receiving unit 91 becomes weak and the liquid component concentration detection accuracy may not be maintained.
  • the light receiving unit By passing the light that has passed through the liquid cell unit 71 to the light collecting unit 10, the light receiving unit The received light intensity of the light received at 91 can be amplified. Therefore, even when the flow rate of the liquid cell unit 71 is increased, the wavelength band absorbed by the liquid becomes clear, the liquid component concentration detection accuracy can be maintained, and a cylindrical tube or the like is used for the liquid cell unit 71. Thereby, the structure of the liquid cell part 71 can be simplified and the cost of equipment itself can be reduced.
  • the said embodiment demonstrated the example in which the condensing part 10 was integrated with the liquid cell part 71, between the liquid cell part 71 and the drainage monitor part 9, light is made into a fixed area
  • a member capable of condensing light may be arranged as the light collecting unit 10. Even in this case, the light that has passed through the liquid cell unit 71 is condensed in a certain region and received by the light receiving unit 91, so that the light receiving intensity at the light receiving unit 91 is increased, thereby improving the liquid component concentration detection accuracy. it can.
  • a quartz cylindrical tube is used for the liquid cell portion 71, but the cylindrical tube may be formed of other members. That is, in the above-described embodiment, since the UV light is irradiated, quartz is used as an example, which absorbs very little UV light. It is preferable in that the absorption of light by a member other than the liquid flowing through the liquid cell portion 71 is suppressed, and the density detection accuracy can be improved.
  • the liquid cell part 71 formed by the parallel plate orthogonal to the light from the irradiation part 81 ( It may be a liquid cell portion formed in a plane perpendicular to the irradiation direction.
  • the liquid cell unit 71 is provided on the cell frame body 72 and the cell frame body 72 is detachable.
  • the liquid cell unit 71 is directly integrated with the housing unit 43. It may be fixed.

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Abstract

La présente invention concerne un détecteur de concentration de composant, qui est capable de conserver la précision de détection de concentration de composant d'un liquide, et de réduire le coût d'un appareil. Plus spécifiquement, ce détecteur de concentration de composant, qui détecte une concentration de composant dans un liquide sur la base d'une absorbance de lumière obtenue par exposition du liquide à la lumière, comprend : une unité de rayonnement qui émet de la lumière ; une unité de réception de lumière qui reçoit la lumière émise par l'unité de rayonnement ; une unité de cellule à liquide, qui est agencée entre l'unité de rayonnement et l'unité de réception de lumière, et dans laquelle circule le liquide ; et une unité de collecte de lumière qui collecte la lumière qui a traversé le liquide dans l'unité de cellule à liquide, ladite lumière ayant été émise à partir de l'unité de rayonnement.
PCT/JP2017/039480 2016-11-14 2017-11-01 Détecteur de concentration de composant WO2018088286A1 (fr)

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JP2016-221436 2016-11-14
JP2016221436A JP2018080925A (ja) 2016-11-14 2016-11-14 成分濃度検出器

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WO2018088286A1 true WO2018088286A1 (fr) 2018-05-17

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JP6992699B2 (ja) * 2018-07-31 2022-01-13 株式会社島津製作所 光散乱検出装置

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60176163U (ja) * 1984-05-01 1985-11-21 株式会社島津製作所 シ−スフロ−セル装置
JPS62108855U (fr) * 1985-12-26 1987-07-11
JPH08178831A (ja) * 1994-12-19 1996-07-12 Rion Co Ltd 光散乱式粒子検出装置
JPH08278247A (ja) * 1995-02-07 1996-10-22 Jasco Corp フローセルアッセンブリ
JP2009510475A (ja) * 2005-10-03 2009-03-12 クリアティーヴィ・マイクロテク，インコーポレーテッド 感応式放出光収集及び検出システム
JP2009222412A (ja) * 2008-03-13 2009-10-01 Jms Co Ltd 成分測定用器具及び成分測定用器具を備えた血液透析装置
JP2013122397A (ja) * 2011-12-09 2013-06-20 Jasco Corp 高耐圧蛍光フローセル、フローセルアッセンブリ、蛍光検出器および超臨界流体クロマトグラフ
JP2014521421A (ja) * 2011-07-25 2014-08-28 ネステク ソシエテ アノニム 赤外線反射エアインラインセンサシステム
JP2016099311A (ja) * 2014-11-26 2016-05-30 横河電機株式会社 試料測定装置
JP2016151526A (ja) * 2015-02-18 2016-08-22 アズビル株式会社 フローセル及びフローセルの製造方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60176163U (ja) * 1984-05-01 1985-11-21 株式会社島津製作所 シ−スフロ−セル装置
JPS62108855U (fr) * 1985-12-26 1987-07-11
JPH08178831A (ja) * 1994-12-19 1996-07-12 Rion Co Ltd 光散乱式粒子検出装置
JPH08278247A (ja) * 1995-02-07 1996-10-22 Jasco Corp フローセルアッセンブリ
JP2009510475A (ja) * 2005-10-03 2009-03-12 クリアティーヴィ・マイクロテク，インコーポレーテッド 感応式放出光収集及び検出システム
JP2009222412A (ja) * 2008-03-13 2009-10-01 Jms Co Ltd 成分測定用器具及び成分測定用器具を備えた血液透析装置
JP2014521421A (ja) * 2011-07-25 2014-08-28 ネステク ソシエテ アノニム 赤外線反射エアインラインセンサシステム
JP2013122397A (ja) * 2011-12-09 2013-06-20 Jasco Corp 高耐圧蛍光フローセル、フローセルアッセンブリ、蛍光検出器および超臨界流体クロマトグラフ
JP2016099311A (ja) * 2014-11-26 2016-05-30 横河電機株式会社 試料測定装置
JP2016151526A (ja) * 2015-02-18 2016-08-22 アズビル株式会社 フローセル及びフローセルの製造方法

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