WO2018082630A1

WO2018082630A1 - Adjustable artificial blood vessel with anti-bleeding function

Info

Publication number: WO2018082630A1
Application number: PCT/CN2017/109206
Authority: WO
Inventors: 卞晓明; 郑成福
Original assignee: 大连科万维医疗科技有限公司
Priority date: 2016-11-07
Filing date: 2017-11-03
Publication date: 2018-05-11
Also published as: CN108066044A; CN108066044B

Abstract

Provided is an adjustable artificial blood vessel with an anti-bleeding function, comprising: an inner tube (1) which is elastically stretchable and constitutes a blood flow passage of the artificial blood vessel; and an outer tube (2) which is sheathed coaxially on an outer wall of the inner tube (1) and is connected with the outer wall of the inner tube (1) by circumferential connection points (3) spaced apart along the length of the inner tube (1) to form a non-continuous multi-section double-layer structure. As an improved artificial blood vessel, the inner tube (1) is uniformly and continuously elastic and stretchable, and the outer tube (2) has lower elasticity and forms a multi-section double-layer structure with the inner tube (1), so as to limit the extension, shortening or bending of the inner tube (1) by adopting different incisions on the outer tube (2) accroding to actual needs, and there is no blood leakage at the anastomosis after surgery. Therefore, the artificial blood vessel is suitable for a variety of replacement surgeries.

Description

Adjustable artificial blood vessel with anti-bleeding function

Technical field

The present invention generally relates to the field of artificial blood vessels. More specifically, it relates to an adjustable artificial blood vessel having an anti-bleeding function.

Background technique

In clinical artificial large vessel replacement surgery, after the natural blood vessel and the artificial blood vessel are anastomosed, due to the pressure of blood flow in the blood vessel, there is often a problem of anastomotic needle hole leakage, which is also the main cause of postoperative complications. In particular, intraoperative hemostasis is the biggest problem for cardiologists. At present, several hemostasis methods used by doctors include: hemostasis to stop bleeding, gauze compression anastomosis to stop bleeding, or use a pericardial tissue or an artificial vascular material to suture the anastomosis to compress and stop the anastomosis. The various methods described above may ultimately be effective but time consuming and ineffective. In the above various methods, the effect of using the pericardial or artificial blood vessel patch to wrap the anastomosis to stop bleeding is relatively good, but since the patch is wrapped in the anastomosis, it is free to be fixed, and it is easy to slip off the in situ, resulting in anastomotic exposure. Continue bleeding.

Therefore, there is a need for a more efficient and easy to implement way to avoid the above problems.

Summary of the invention

SUMMARY OF THE INVENTION The present invention is directed to an improved artificial blood vessel that does not have a blood leakage problem after the replacement surgery, and that the artificial blood vessel can be applied to various occasions in which the length or the curvature is adjusted according to the post-transplant condition.

To this end, according to an aspect of the present invention, an adjustable artificial blood vessel having an anti-bleeding function is provided, the artificial blood vessel comprising: an inner tube that is elastically stretchable and constitutes a blood flow passage of the artificial blood vessel And an outer tube coaxially nested on the outer wall of the inner tube and connected to the outer wall of the inner tube by a circumferential direction spaced along the length of the inner tube The points are connected to each other to form a discontinuous multi-stage two-layer structure.

In accordance with the above technical concept, the present invention may further include any one or more of the following preferred forms.

In certain preferred forms, the outer tube comprises a plurality of segmented outer tubes distributed along the length of the inner tube.

In some preferred forms, the outer tube is made of a different elastomeric material than the inner tube.

In certain preferred forms, the outer tube is less elastic than the inner tube.

In certain preferred forms, the outer wall of the inner tube is configured to fold in the length direction.

According to another aspect of the present invention, there is also provided a method of using the above-described adjustable artificial blood vessel having an anti-bleeding function, wherein the method comprises: incision of one or more outer layer tubes to change the artificial The length or curvature of the blood vessel.

In some preferred forms, the wall of the outer tube is annularly cut over the entire circumference, and the inner tube is stretched to extend the length of the artificial blood vessel.

In some preferred forms, the wall of the outer tube is circularly cut at a full circumference, the inner tube is compressed, and the edge of the tube wall of the cut outer tube is tightly connected to each other, thereby shortening the artificial blood vessel length.

In some preferred forms, the tube wall of the outer tube is cut in half or partially, and the inner tube is bent and stretched to adjust the curvature of the artificial blood vessel.

In some preferred forms, the wall of the inner tube is cut all over the circumference, and the outer tube is annularly cut at a position extending beyond the section of the inner tube to the inner layer. After the tube is anastomosed with the natural blood vessel, the wall of the free outer tube can be tightly wrapped around the anastomosis to prevent bleeding.

According to still another aspect of the present invention, there is also provided a method of manufacturing an adjustable artificial blood vessel having an anti-bleeding function, the artificial blood vessel comprising an inner tube and a coaxial inlay which elastically expand and constitute a blood flow passage of the artificial blood vessel An outer tube positioned over an outer wall of the inner tube, wherein the method includes: arranging spaced apart circumferential joints along a length of the inner tube; and placing the outer tube with the The outer walls of the inner tube are connected to each other by the circumferential connection point.

In some preferred forms, the inner tube is made of polyester or polytetrafluoroethylene.

In certain preferred forms, the inner tube comprises a wire or a memory alloy material.

In certain preferred forms, the outer tube is made of a material that is less elastic than the inner tube.

In certain preferred forms, the attachment of the outer tube to the inner tube comprises bonding with an adhesive, stitching with a suture, or physical fusion by high temperature and high pressure.

The invention provides an improved artificial blood vessel, wherein the inner tube has continuous uniform elasticity and elasticity; the outer tube has low elasticity and forms a multi-layer double-layer structure with the inner tube, so that the outer tube can be different according to actual needs. The incision method is used to limit the extension, shortening, or bending of the inner tube and the absence of blood leakage at the postoperative anastomosis. Therefore, the present invention is applicable to a variety of replacement surgical situations.

DRAWINGS

The invention will be better understood by the following description of specific embodiments, which are illustrated by way of example only,

1 is a schematic view of an artificial blood vessel in accordance with a preferred embodiment of the present invention;

Figure 2A is a cross-sectional view taken along line A-A of Figure 1;

Figure 2B is a cross-sectional view taken along line B-B of Figure 1;

Figure 3 is a schematic view showing the application of an artificial blood vessel according to the present invention to a natural blood vessel;

Figure 4 is a schematic view showing a section of the outer layer tube cut around the entire circumference to stretch the inner tube;

Figure 5 is a schematic view showing the edge of the tube wall of the outer tube cut in Figure 4 being sewed to each other to shorten the length of the artificial blood vessel;

Figure 6 is a schematic illustration of a section of the outer tube that is cut or partially cut to bend the inner tube.

detailed description

The implementation and use of the embodiments are discussed in detail below. It should be understood, however, that the specific embodiments of the invention are not to be construed

Referring first to Figures 1, 2A and 2B, an adjustable artificial blood vessel having an anti-bleeding function in accordance with a preferred embodiment of the present invention is illustrated. The artificial blood vessel includes an elastically stretchable inner tube 1 which constitutes a blood flow passage of the artificial blood vessel, and an outer tube 2 coaxially nested on the outer wall of the inner tube 1. According to the invention, spaced apart circumferential joints 3 are arranged along the length of the inner tube 1. In certain embodiments, the circumferential joints 3 are arranged at even intervals to form a discontinuous multi-stage two-layer structure after joining the outer tube to the outer wall of the inner tube, ie, the outer tube and the inner tube Segmented separation. In certain embodiments, the outer layer tube 2 may further comprise a plurality of segmented outer layer tubes distributed along the length of the inner tube 1 and the circumferential connection points 3 are arranged such that the plurality of segmented outer tubes They are separated at a uniform predetermined interval to form a discontinuous multi-stage two-layer structure, as shown in FIG. In such an embodiment, as shown in the AA section shown in Fig. 2A, the artificial blood vessel includes a two-layer structure formed by the inner tube 1 and the outer layer tube 2, and at the BB section shown in Fig. 2B, the artificial blood vessel is only Includes inner tube 1.

According to the present invention, the inner tube 1 can be made of the same material and structure as the existing artificial blood vessel products on the market to serve as blood flow channels. Preferably, the inner tube 1 is made of a medically vascular material having a relatively large elasticity, such as an artificial blood vessel material such as polyester or polytetrafluoroethylene, so that the length of the axially outwardly drawn blood vessel can be extended, and the blood vessel is pushed axially inward. The length can be shortened. The outer layer tube 2 is made of a different elastic material than the inner tube 1, preferably a less flexible medical vascular material. In certain preferred embodiments, the inner tube 1 may also comprise a wire or memory alloy material to allow for a fixed shape. According to the embodiment illustrated in Figure 1, the outer wall of the inner tube can also be configured to fold along the length to aid in the stretching and compression of the inner tube as the length of the blood vessel is adjusted.

In the above manner, the inner tube of the artificial blood vessel according to the present invention is no different from the ordinary artificial blood vessel, and functions as a blood flow channel, and the outer tube can be circularly cut according to actual needs to change the length of the artificial blood vessel. Thus, the unique artificial blood vessel having a two-layer structure can be applied clinically, and at least the following functions can be realized:

1. When the inner tube 1 and the natural blood vessel 5 (end-end) are anastomosed when the artificial blood vessel is transplanted, the

tube wall

2a, 2b of the free outer tube 2 extending beyond the cross-sectional position of the inner tube 1 at the artificial blood vessel port may be For example, the suture is circumferentially sutured and tightened to naturally cover the anastomosis that has been sutured by the suture 4 to prevent blood leakage and oozing of the anastomosis, as shown in FIG. 3;

2. When the inner tube 1 is anastomosed with the natural blood vessel when the artificial blood vessel is transplanted, if the length of the transplanted blood vessel is not ideal (frequently occurring), for example, the grafted artificial blood vessel is too short, the outer tube 2 can be fully circumferential (360°). Cutting (laterally), stretching the inner tube 1, as shown in Figure 4, thereby extending the length of the blood vessel;

3. When the inner tube 1 is anastomosed with the natural blood vessel when the artificial blood vessel is transplanted, if the length of the transplanted blood vessel is too long, the inner tube 1 can be compressed after the inner circumference tube 2 is circularly cut, and the outer tube 2 is The edges of the

cut tube walls

2a, 2b are, for example, stapled by sutures 4, as shown in Figure 5, thereby achieving a shortened blood vessel length;

4. When the inner tube 1 is anastomosed with the natural blood vessel when the artificial blood vessel is transplanted, if the curvature/angle/curvature of the transplanted blood vessel is not ideal, the wall of the outer tube 2 may be cut in half or partially transversely, as shown in the figure. As shown in Fig. 6, at this time, the inner tube 1 can be bent and stretched, thereby adjusting the curvature of the artificial blood vessel.

It should be understood that the connection of the outer layer tube 2 to the inner tube 1 is not limited to sewing with a suture, but may be bonded using an adhesive or by physical fusion at a high temperature and a high pressure.

The invention provides an artificial blood vessel having an outer tube and an inner tube, and forms a multi-stage double-layer structure with the inner tube for the blood flow passage, and the special structure of the outer tube can be covered in the anastomosis A flawless hemostasis effect is achieved on the mouth. In addition, the length of the blood vessel can be lengthened or shortened by circularly cutting or tightening the one or more outer layer tubes throughout the circumference. The curvature of the blood vessel can also be adjusted by half-circle or partial incision of the outer tube. Thus, the artificial blood vessel of the present invention can be applied to various applications.

The basic principles, the main features and the technical features of the present invention have been disclosed and described above, and it is understood that those skilled in the art can make the above-mentioned technical features and embodiments without departing from the spirit and scope of the present invention. Various changes and modifications are intended to fall within the scope of the invention. The description of the above embodiments is illustrative and not restrictive, and the scope of the invention is defined by the claims.

Claims

An adjustable artificial blood vessel having an anti-bleeding function, characterized in that the artificial blood vessel comprises:

An inner tube that is elastically stretchable and constitutes a blood flow passage of the artificial blood vessel;

An outer layer tube coaxially nested on an outer wall of the inner tube and intersecting with an outer wall of the inner tube through a circumferential connection point spaced along a length of the inner tube Connected to form a discontinuous multi-stage two-layer structure.
The artificial blood vessel according to claim 1, wherein said outer layer tube comprises a plurality of segmented outer layer tubes distributed along a length direction of said inner tube.
The artificial blood vessel according to claim 1 or 2, wherein the outer layer tube is made of a different elastic material than the inner layer tube.
The artificial blood vessel according to claim 3, wherein the outer tube is less elastic than the inner tube.
The artificial blood vessel according to claim 1 or 2, wherein the outer wall of the inner tube is provided to be pleated in the longitudinal direction.
A method of using an adjustable artificial blood vessel having an anti-bleeding function according to any of the preceding claims, characterized in that the method comprises: incision of one or more outer layers of the tube to change the artificial The length or curvature of the blood vessel.
The method according to claim 6, wherein the wall of the inner tube is cut all the way, and the outer tube is circularly cut at a position extending beyond a section of the inner tube. When the inner tube is in agreement with the natural blood vessel, the wall of the free outer tube can be tightly wrapped around the anastomosis to prevent bleeding.
The method according to claim 6, wherein the wall of the outer tube is annularly cut around the entire circumference, and the inner tube is stretched to extend the length of the artificial blood vessel.
The method according to claim 6, wherein the wall of the outer tube is annularly cut at a full circumference, the inner tube is compressed and the edge of the tube wall of the cut outer tube is tightened to each other Connect to shorten the length of the artificial blood vessel.
The method of claim 6 wherein the wall of the outer tube is Half-circle or partial incision, bending the inner tube to adjust the curvature of the artificial blood vessel.
A method for manufacturing an adjustable artificial blood vessel having an anti-bleeding function, the artificial blood vessel comprising an inner tube elastically extending and constituting a blood flow passage of the artificial blood vessel and coaxially nested on an outer wall of the inner tube Outer tube, characterized in that the method comprises:

Arranging spaced apart circumferential joints along the length of the inner tube;

The outer tube and the outer wall of the inner tube are connected to each other by the circumferential connection point.
The method of manufacturing a two-layer structure artificial blood vessel according to claim 11, wherein the inner tube is made of polyester or polytetrafluoroethylene.
The method of manufacturing a two-layer structure artificial blood vessel according to claim 11 or 12, wherein the inner tube comprises a wire or a memory alloy material.
The method of manufacturing a two-layer structure artificial blood vessel according to claim 11, wherein the outer layer tube is made of a material having elasticity lower than that of the inner tube.
The method of manufacturing a two-layer structure artificial blood vessel according to claim 11, wherein the connection of the outer layer tube to the inner layer tube comprises bonding with an adhesive, suturing with a suture or by high temperature and high pressure physics. Fusion.