Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
  • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
  • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
  • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
  • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
  • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
  • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K49/00—Preparations for testing in vivo
  • A61K49/04—X-ray contrast preparations
  • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
  • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
  • A61K49/0461—Dispersions, colloids, emulsions or suspensions
  • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P35/00—Antineoplastic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B6/48—Diagnostic techniques
  • A61B6/481—Diagnostic techniques involving the use of contrast agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N5/00—Radiation therapy
  • A61N5/06—Radiation therapy using light
  • A61N5/0613—Apparatus adapted for a specific treatment
  • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Definitions

• the present invention discloses cancer binding radio-opaque peptides that are targeted for disintegration by radiant energy and related methods.
• Embodiments of the present invention provide cancer binding radio- opaque peptides that are targeted for disintegration by radiant energy and related methods.
• Surgical removal of a tumorous lesion is risky, because of the risk of dislodging cancerous cells when cutting at or near the tumor, which unfortunately transports them throughout the body via the bloodstream.
• Dislodged cancer cells most often collect within the lymph nodes where the cancer continues to spread throughout the body.
• One major function of chemotherapy is to manage the spread of cancer that is caused by dislodged cells after surgery. What are needed are devices and methods that do not require the surgical cutting of the tumor in order to remove it.
• Contemporary surgical methods intentionally remove large areas of healthy biological tissue when removing cancerous lesions. What are needed are devices and methods that specifically target cancer cells while leaving healthy cells and tissue more or less intact.
• the present invention provides a means to radiographically identify and mark cancer cells for destruction, while leaving healthy biological tissue un-marked.
• the present invention marks cancerous cells so they become more susceptible to disintegration by the absorption of radiant energy than un-marked healthy cells and tissue.
• the amount of absorbed energy is by design sufficient to destroy the marked cell; the cell becomes in effect burned and exhibits the by-products of combustion.
• the present invention provides a means to locate and identify/define the tumorous lesion in order to guide the radiant energy source to the treatment site.
• the present invention provides a means to radiographically locate and identify the tumorous
• the present invention utilizes Radio-opaque peptides as biological active compounds that are known to have the ability to collect in tumorous lesions.
• the present invention utilizes peptides, polypeptides, polymers,
• biopolymers and proteins as biological active compounds that are known to have the ability to collect in tumorous lesions.
• the biological active compounds comprising:
• peptides, polypeptides, polymers, biopolymers and proteins are generically referred to as "Peptides".
• An embodiment of the present invention prefers a group of peptides, polypeptides, polymers, biopolymers and proteins that bind to fibrinogen and fibrin.
• An embodiment of the present invention is designed to flood an organism with Radio-opaque peptides wherein the peptides collect within the cancer cells that in effect mark them for disintegration. Once marked, the cancerous lesion is radiated with radiant energy wherein the bound peptide readily absorbs the incoming radiation and transforms the energy into heat. The cancerous lesion is radiated with sufficient energy such that the peptide-marked cell becomes burned and exhibits the byproducts of combustion.
• An embodiment of the present invention selects a source of
• a preferred embodiment of the present invention selects a radiant energy source that is least likely to be absorbed by healthy biological tissue and at the same time maximizes absorption to the peptide targeting molecule; wherein healthy unmarked cells are less likely to be destroyed by the incoming radiation because they are significantly less absorbent to the radiant energy source; wherein the radiant energy becomes dissipated throughout a deep column of healthy tissue comprising a much larger dissipation area.
• a peptide can be introduced into a patient's bloodstream wherein the peptide collects within the cancerous lesion and not within healthy cells.
• the peptide-marked tumor is then subject to a radiant energy source whose
• the cancerous lesion is radiated with sufficient energy such that a portion or all of
• peptide-marked tumor becomes burned and exhibits the by-products of combustion.
• the body is then allowed to heal wherein the natural physiological processes of the body remove the destroyed cells. If only a portion of the tumor is radiated, then
• multiple treatments can be implemented as the tumor is systematically destroyed a portion at a time after a healing interval.
• a radio-opaque phospholipid is created by adding a radio-opaque moiety onto a peptide.
• the present invention utilizes heavy elements as a source of radio- opaque substances such as: iodine, bromine, calcium, barium, strontium, bismuth, tungsten, zirconium, iron, copper, nickel, zinc, silver, tin, gallium, antimony,
• radio-opaque substances can be used in their elemental form, as a salt, bound in chelated form, or as an organometallic compound. Any radio-opaque moiety that can be attached to a peptide that does not inhibit the resultant compound's ability to collect and bind to cancer cells is within the scope of this patent.
• peptides of the present invention can utilize peptides that are naturally chromatic and/or those peptides that are made chromatic by the addition of a chromatic moiety.
• a preferred embodiment of the present invention comprises a radio-opaque peptide that is chromatic as well.
• An embodiment of the present invention has structure:
• P is a peptide, polypeptide, polymer, biopolymer or protein.
• L is a linkage moiety or polymer such as those listed but not limited to those disclosed under "Crosslinkers" in patent 8,513,380.
• R is a radio-opaque moiety that comprises a radio-opaque heavy element, a radio-opaque organometallic compound, a radio- opaque salt, and/or a radio-opaque metal bound by chelation.
• M is 0 or l.N is a
• Another embodiment of the present invention has structure:
• P is a peptide, polypeptide, polymer, biopolymer or protein.
• L is a linkage moiety or polymer such as those listed but not limited to those disclosed under "Crosslinkers" in United States Patent No. 8,513,380.
• R is a radio-opaque moiety that comprises a radio-opaque heavy element, a radio-opaque organometallic compound, a radio-opaque salt, and/or a radio-opaque
• M is a number from 0 to 10,000.
• N is a number from 1 to 10,000.
• Radio-opaque peptide can be delivered to the organism by way of injection with the appropriate peptide being dissolved in physiological saline or other solution, it can also be delivered orally in tablet or capsule form when blended with the appropriate binding agents, or by any other pharmaceutically accepted method.
• the radiant energy source of the present invention comprises both
• radiant energy sources include but are not limited to: incoherent light sources such as filament lamps, halogen lamps, fluorescent lamps, plasma lamps and any other incoherent source of light.
• Coherent sources of light include but are not limited to lasers such as gas lasers, chemical lasers, excimer lasers, solid-state lasers, diode lasers, photonic crystal lasers, dye lasers, fiber lasers, free electron lasers and any other coherent source of light.
• the present invention comprises a method that matches the source of radiant energy to the absorption characteristics of a particular radio-opaque peptide compound.
• a radio-opaque peptide compound is selected based upon its
• An embodiment of the present invention utilizes the absorption lambda max of a peptide as the matching emission wavelength required by the radiant energy source.
• the treatment regime would introduce a radio-opaque peptide into the patient's blood stream allowing sufficient time for the peptide to target and bind to the cancerous cells within the tumor.
• the tumor could then be located and defined by radiography. Based upon analysis of the x-rays, a treatment strategy is planned and
• the radiant energy can be delivered to the treatment area by direct

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• Health & Medical Sciences (AREA)
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• Immunology (AREA)
• Epidemiology (AREA)
• Medical Informatics (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Physics & Mathematics (AREA)
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• Proteomics, Peptides & Aminoacids (AREA)
• Urology & Nephrology (AREA)
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• 2017
  • 2017-10-25 JP JP2019522653A patent/JP2019534285A/ja active Pending
  • 2017-10-25 US US16/345,066 patent/US20190274645A1/en not_active Abandoned
  • 2017-10-25 CN CN201780071482.1A patent/CN109963875A/zh active Pending
  • 2017-10-25 WO PCT/US2017/058269 patent/WO2018081256A1/en not_active Ceased

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