WO2018080396A3 - Compounds and methods to target a molecule to a specific cellular location - Google Patents

Compounds and methods to target a molecule to a specific cellular location Download PDF

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Publication number
WO2018080396A3
WO2018080396A3 PCT/SG2017/050533 SG2017050533W WO2018080396A3 WO 2018080396 A3 WO2018080396 A3 WO 2018080396A3 SG 2017050533 W SG2017050533 W SG 2017050533W WO 2018080396 A3 WO2018080396 A3 WO 2018080396A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecule
compounds
target
methods
specific cellular
Prior art date
Application number
PCT/SG2017/050533
Other languages
French (fr)
Other versions
WO2018080396A2 (en
Inventor
Shenquan Pan
Xiaoyang Li
Original Assignee
National University Of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Of Singapore filed Critical National University Of Singapore
Priority to CN201780065902.5A priority Critical patent/CN110036021B/en
Publication of WO2018080396A2 publication Critical patent/WO2018080396A2/en
Publication of WO2018080396A3 publication Critical patent/WO2018080396A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to a peptide comprising or consisting of (i) the amino acid sequence of SEQ ID NO:1 or (ii) an amino acid sequence having at least 80% sequence identity to the amino acid sequence of SEQ ID NO:1 over its entire length. The present invention also relates to a conjugate, a host cell, a bio-imaging system, a method to visualize internalization, a method to internalize a drug into a cell and the conjugate of the invention for use as a medicament or the use of the conjugate of the invention as a research agent.
PCT/SG2017/050533 2016-10-24 2017-10-24 Compounds and methods to target a molecule to a specific cellular location WO2018080396A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201780065902.5A CN110036021B (en) 2016-10-24 2017-10-24 Compounds and methods for targeting molecules to specific cellular locations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201608928QA SG10201608928QA (en) 2016-10-24 2016-10-24 Compounds and methods to target a molecule to a specific cellular location
SG10201608928Q 2016-10-24

Publications (2)

Publication Number Publication Date
WO2018080396A2 WO2018080396A2 (en) 2018-05-03
WO2018080396A3 true WO2018080396A3 (en) 2018-09-27

Family

ID=62025316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2017/050533 WO2018080396A2 (en) 2016-10-24 2017-10-24 Compounds and methods to target a molecule to a specific cellular location

Country Status (3)

Country Link
CN (1) CN110036021B (en)
SG (1) SG10201608928QA (en)
WO (1) WO2018080396A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060037099A1 (en) * 2002-11-20 2006-02-16 Stefan Werner Method of controlling gene expression in plants or plant cells
US20090271896A1 (en) * 2006-08-07 2009-10-29 Ajith Anand Method for agrobacterium-mediated transformation of plants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060037099A1 (en) * 2002-11-20 2006-02-16 Stefan Werner Method of controlling gene expression in plants or plant cells
US20090271896A1 (en) * 2006-08-07 2009-10-29 Ajith Anand Method for agrobacterium-mediated transformation of plants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE Protein [O] 26 May 2015 (2015-05-26), XP055547849, retrieved from NCBI Database accession no. WP_012478091.1 *
LI, XIAOYANG ET AL.: "Agrobacterium delivers VirE2 protein into host cells via clathrin-mediated endocytosis", SCIENCE ADVANCES, vol. 3, no. 3, 22 March 2017 (2017-03-22), pages e1601528, XP055547852 *
LI, XIAOYANG ET AL.: "Direct visualization of Agrobacterium-delivered VirE2 in recipient cells", THE PLANT JOURNAL, vol. 77, no. 3, 16 January 2014 (2014-01-16), pages 487 - 495, XP055509100 *
SAKALIS, PHILIPPE A. ET AL.: "Visualization of VirE2 protein translocation by the Agrobacterium type IV secretion system into host cells", MICROBIOLOGYOPEN, vol. 3, no. 1, February 2014 (2014-02-01), pages 104 - 117, XP055547846 *

Also Published As

Publication number Publication date
CN110036021A (en) 2019-07-19
SG10201608928QA (en) 2018-05-30
CN110036021B (en) 2023-04-11
WO2018080396A2 (en) 2018-05-03

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