WO2018080281A1 - Appareil et procédé de modification de la peau au moyen d'un laser et d'un plasma - Google Patents

Appareil et procédé de modification de la peau au moyen d'un laser et d'un plasma Download PDF

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Publication number
WO2018080281A1
WO2018080281A1 PCT/KR2017/012172 KR2017012172W WO2018080281A1 WO 2018080281 A1 WO2018080281 A1 WO 2018080281A1 KR 2017012172 W KR2017012172 W KR 2017012172W WO 2018080281 A1 WO2018080281 A1 WO 2018080281A1
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Prior art keywords
plasma
laser
skin
light
hair growth
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PCT/KR2017/012172
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English (en)
Korean (ko)
Inventor
윤상원
김정현
김석형
최은욱
이원종
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㈜프로스테믹스
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Priority claimed from KR1020170143710A external-priority patent/KR102002825B1/ko
Priority claimed from KR1020170143711A external-priority patent/KR20180048397A/ko
Publication of WO2018080281A1 publication Critical patent/WO2018080281A1/fr

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    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/46—Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

Definitions

  • the present invention relates to a skin reforming apparatus and a method for reforming using a laser and plasma, and more particularly, to a skin reforming apparatus and a method for reforming using a laser and plasma to stimulate the skin and scalp to promote regeneration.
  • Human skin tissue is composed of the epidermis and the subcutaneous tissue below it, the epidermal layer having a stratum corneum acts as a biological barrier to the environment, the melanin cells that determine the skin color is present in the base layer.
  • the lower subcutaneous tissue maintains the structure of the skin by the extracellular collagen acts as a support.
  • Collagen is synthesized by fibroblasts and is a protein in which three polypeptides form a spiral structure.
  • the body When injured, the body activates a complex remedy, of which fibroblasts are present under the skin and are activated to temporarily enter the extra cellular matrix (ECM) to cover the wound as soon as possible. Secrete. As fibroblasts slowly move around the matrix, attracting fibers to recombine the matrix, making the matrix more rigid, and because of the growth factors contained in the matrix that were initially soft, the fibroblasts expressed contractile proteins by the growth factors, At some point, the fibroblasts stop moving and turn into strong contractile cells, such as popeye, that settle in the matrix and attract the edges of the wound, resulting in scarring or uneven surface of the skin.
  • ECM extra cellular matrix
  • the collagen fibrous tissue is heated by a predetermined energy source, degeneration of the physical properties of the protein matrix occurs at a specific temperature, molecular binding of the matrix is broken, and the condition of the skin becomes even, and also activates the collagen layer. The elasticity of the skin can be restored.
  • the solid with the lowest energy state among the materials receives energy and is transferred to a liquid or gas.
  • a plasma including electrons, ions, neutral atoms, and molecules may be generated by ionization and recombination of electrons and ions.
  • Plasma is called ionized conductive gas species because the positive and negative charges are mixed in the plasma to maintain Brown's motion close to free particles and to remain electrically neutral.
  • Plasma classification criteria include plasma density, electron temperature, degree of thermal equilibrium (LTE or non-LTE) between species, generation mode, and application field.
  • Plasma for research and manufacturing processes is usually either LTE or non-LTE, and the former is commonly referred to as thermal plasma and the latter as low temperature plasma.
  • Atmospheric pressure plasma in low temperature plasma is mainly used in the field of surface modification and coating, environmental purification.
  • research has been expanded to include bioapplications and biomedical applications.
  • many atmospheric pressure plasma apparatuses have been studied (Korean Patent No. 1407672 and Korean Patent No. 1292268).
  • the present invention relates to a device for modifying skin and scalp using a laser and a plasma, and to a method for modifying the plasma and the plasma according to the present invention, since hair growth from the scalp promotes hair growth and significantly increases the proliferation of dermal papilla cells. It is expected to be used greatly.
  • Patent Document 0001 Republic of Korea Patent Publication No. 10-1407672 (2006.07.04.)
  • the present invention was created to improve the problems of the skin and scalp reforming method using a conventional laser and plasma as described above, the skin and scalp reforming apparatus using a laser and plasma to induce regeneration of the skin by laser and plasma And to provide a method.
  • the hair growth promoting apparatus includes a laser generator configured to irradiate a laser beam by a power applied from a power supply device, and a power supply from the power supply device to generate a potential difference, thereby generating a plasma. Characterized in that it comprises a plasma generating portion formed to generate.
  • the skin modification method using the device is characterized in that it comprises a laser irradiation step of irradiating the laser to the skin, and a plasma treatment step of treating the plasma to the skin.
  • control unit may further include a controller connected to the power supply device and configured to control power applied to the laser generator and the plasma generator.
  • the laser generating unit and the plasma generating unit may be provided independently of each other to operate individually.
  • the laser generating unit and the plasma generating unit may further include a handpiece body coupled.
  • the laser generation unit may be connected to one end of the handpiece body, and may generate a laser having a wavelength of 500 nm or more and 700 nm or less using LD or LED as a light source.
  • the plasma generator may be disposed to be spaced apart from the laser generator, and may generate a plasma by a potential difference, and a pinhole may be formed to pass the laser generated by the laser generator.
  • the plasma generating unit may include a plasma electrode for generating a dielectric barrier plasma, and an electrode holder formed to receive the plasma electrode.
  • the plasma generating unit may further include a spacer which protrudes to contact the skin to generate a predetermined space between the skin and the plasma electrode.
  • the plasma electrode may include a metal electrode generating a potential difference using an applied voltage, and a dielectric layer formed to stabilize the plasma by surrounding the metal electrode.
  • the plasma electrode may have the metal electrode and the dielectric layer formed in a lattice form so that the pinhole is formed.
  • the bridge may be extended to correspond to the laser focusing distance of the laser generation unit.
  • the controller may alternately operate the laser generator and the plasma generator.
  • the controller may operate the laser generator and the plasma generator at the same time.
  • the power supply device may output a current in the form of a sine wave (sine wave).
  • pulse streamer discharges silent discharges, partial discharges, creepage discharges and corona discharges.
  • the laser irradiation step it is also possible to irradiate the skin with a peelable laser.
  • the laser irradiation step it is also possible to irradiate the laser to the skin by a low power laser therapy method.
  • the skin modification method may also be performed after the laser irradiation step.
  • the skin modification method may be to perform the laser irradiation step after the plasma treatment step.
  • the laser irradiation step and the plasma generating step may be performed according to a predetermined pattern.
  • the laser may be irradiated with a wavelength of 1500 nm or more and 11000 nm or less.
  • the laser may be irradiated with a wavelength of 500 nm or more and 700 nm or less.
  • the device of the present invention is a cosmetic use for skin modification, and may further be used to improve skin wrinkles or to promote transdermal absorption of compositions such as cosmetics.
  • "Beauty” in the present invention is intended to beautify the appearance of a healthy subject, and is clearly distinguished from the concept of "treatment” performed in a subject having a disease.
  • the laser generating unit is formed so that the laser is irradiated by the power applied from the power supply; And a plasma generator configured to receive power from the power supply, and generate a potential difference to generate plasma, wherein the hair growth promoting device is connected to the power supply and is connected to the laser generator and the plasma. And a control unit provided to control the power applied to the generating unit.
  • the hair growth promoting apparatus further comprises: the laser generating unit and the plasma generating unit are provided independently of each other to operate individually. It provides a hair growth promoting device, and provides a hair growth promoting device further comprises; a handpiece body coupled to the laser generator and the plasma generator.
  • the laser generating unit is connected to one end of the handpiece body, the LD or LED as a light source, the hair growth promoting device, characterized in that for generating a laser having a wavelength of 500nm or more, 700nm or less to provide.
  • the plasma generating unit is arranged to be spaced apart from the laser generating unit, generating a plasma by the potential difference, the hair growth promoting device characterized in that the pinhole is formed to pass the laser generated in the laser generating unit And a bridge extending from the laser generating portion side end of the handpiece body to be connected to the plasma generating portion to prevent damage to the skin.
  • the plasma generating unit includes: a plasma electrode for generating a dielectric barrier plasma; And an electrode holder formed to receive the plasma electrode, wherein the plasma generating unit is formed to protrude to generate a predetermined space between the skin and the plasma electrode in contact with the skin. It provides a hair growth promoting apparatus further comprising a spacer.
  • the plasma electrode a metal electrode for generating a potential difference using an applied voltage; And a dielectric layer formed to surround the metal electrode to stabilize the plasma, wherein the plasma electrode comprises: the metal electrode and the dielectric layer formed in a lattice form such that the pinhole is formed. It provides a hair growth promoting device, characterized in that.
  • the bridge is provided in accordance with the laser focusing distance of the laser generating unit, characterized in that the hair growth promoting device, characterized in that the control unit alternately to operate the laser generating unit and the plasma generating unit.
  • a hair growth promoting apparatus is provided, wherein the controller provides the hair growth promoting apparatus, wherein the laser generating unit and the plasma generating unit are operated at the same time, and the power supply device is in the form of a sine wave (sine wave).
  • a hair growth promoting device characterized by outputting a current.
  • a skin modification method comprising the step of co-processing the plasma and light on the skin, wherein the co-treatment of the plasma and light, the plasma pre-treatment and post-treatment, or the light It provides a skin modification method of pretreatment and post-treatment of plasma, simultaneous treatment of plasma and light, or alternately repeating treatment of plasma and laser, wherein the skin modification is performed on the skin of the plasma-treated area and of the light-treated area.
  • a method of skin modification characterized in that the skin is superimposed.
  • the plasma is a skin modification method is a low-temperature plasma
  • the low temperature plasma is a skin modification method is a plasma by pulse streamer discharge, silent discharge, partial discharge, creeping discharge, or corona discharge.
  • the light is a skin modification method
  • the laser is a skin modification method, which is a skin-derived laser
  • the laser is a skin modification method, which is a laser of low power laser therapy
  • the light is a skin characterized in that the wavelength of 605nm to 650nm. Provide a method of reforming.
  • the skin is a skin modification method that is the scalp, and the skin modification provides a skin modification method of inhibiting hair loss, promoting hair growth, or strengthening the hair root.
  • the plasma is a skin modification method for treating 5 to 40 J / cm 2 to the skin
  • the plasma is a skin modification method to treat 10 to 20 J / cm 2 to the skin
  • the light Is a skin modification method for treating the skin at 2 to 16 J / cm 2
  • the light provides a skin modification method for treating the skin at 2 to 8 J / cm 2 .
  • the laser and the scalp are stimulated, and the plasma is penetrated into the irritated skin and the scalp to increase the regeneration effect. It is effective in promoting hair growth.
  • FIG. 1 is a flowchart illustrating a method for reforming skin and scalp using laser and plasma according to an embodiment of the present invention
  • FIG. 2 is a block diagram of an apparatus for performing skin and scalp modification using laser and plasma according to an embodiment of the present invention
  • FIG. 3 is a perspective view of a device for performing the method of skin and scalp modification using a laser and plasma according to an embodiment of the present invention
  • FIG. 4 is an enlarged perspective view of a plasma generator and a laser generator in FIG. 3;
  • FIG. 5 is a front view of the plasma generator in FIG. 3;
  • FIG. 6 is a cross-sectional view showing a cross section of a portion indicated by A-A in FIG. 5;
  • FIG. 7 is a result showing the scalp stimulation effect using a laser and a plasma according to an embodiment of the present invention.
  • plasma of various energies was combined with red wavelength light in human hair follicle dermal papilla cells.
  • the energy range of the plasma is preferably 5 to 40 J / cm 2 , more preferably 10 to 20 J / cm 2 .
  • the energy range of the plasma is preferably 5 to 20 J / cm 2 and the light of the red wavelength is 2 to 16 J / cm 2
  • the energy of the plasma is 10 to More preferably, the light of 20 J / cm 2 and the red wavelength is 2 to 16 J / cm 2
  • the energy range of the plasma is 10 to 20 J / cm 2 and the light of the red wavelength is 2 to 8 J / cm 2 .
  • reference numeral 100 denotes a handpiece body
  • 200 denotes a laser generator
  • 300 denotes a plasma generator
  • 310 denotes an electrode holder
  • 330 denotes a plasma electrode
  • 331 denotes a metal electrode
  • 333 denotes a dielectric layer
  • 335 denotes a pinhole
  • 350 denotes a spacer
  • 400 denotes a bridge
  • 500 denotes a power supply
  • 600 denotes a control unit.
  • a method for modifying skin and scalp using a laser and a plasma includes a laser irradiation step (S10) and a plasma processing step (S20).
  • the laser irradiation step (S10) and the plasma processing step (S20) is not only performed independently of each other, but also after the laser irradiation step (S10) to perform the plasma processing step (S20) or the plasma processing step (S20) After the laser irradiation step (S10) may be performed, the laser irradiation step (S10) and the plasma processing step (S20) may be performed simultaneously or alternately with each other, and performed according to a predetermined pattern. It is also possible.
  • the laser irradiation step (S10) is irradiated with a laser on the skin (scalp).
  • the laser irradiated to the skin (scalp) includes a peelable laser.
  • Dermabrasive lasers have the effect of irritating the skin's epidermis (CO 2 laser and Erbium Yag laser) or dermis (fractional laser) to regenerate the skin.
  • the laser irradiation step (S10) it is also possible to use a laser used for Low Level Laser Treatment (LLLT). That is, by irradiating a laser having a wavelength of 500nm or more and 700nm or less, there is an effect of expanding the blood vessels and improving blood circulation to restore the skin.
  • LLLT Low Level Laser Treatment
  • a laser (energy source) having a wavelength of 500 nm or more and 700 nm or less and using a laser diode (LD) or a light emitting diode (LED) as a light source may be used.
  • Hair repeats three stages of growth, rest, and degeneration, called hair cycles.
  • the laser having the above wavelength (wavelength of 500 nm or more and 700 nm or less) stimulates metabolism by stimulating hair follicles of the resting and degeneration phases. Since the above wavelength (wavelength above 500nm and below 700nm) is specifically absorbed by blood vessels and hair follicles compared to other wavelengths, the above effect can be expected.
  • the plasma is treated on the skin (scalp).
  • the plasma irradiated to the skin (scalp) includes a low temperature plasma.
  • Discharges forming low temperature plasma include pulse streamer discharge, silent discharge, partial discharge, creepage discharge and corona discharge.
  • the pulse streamer discharge is applied to a pulsed high voltage with a rise time of several tens of milliseconds and a duration of about 1 milliseconds or less, and a streamer discharge occurs to form a plasma.
  • the application of alternating current high voltage causes pulsed discharge, and the spray discharge is the installation of metal mesh electrodes on both sides of the filling of the ceramic ferret with a particle diameter of several mm and the application of alternating current high voltage. It happens in the middle.
  • the dielectric barrier plasma belonging to the silent discharge it is possible to generate a controlled plasma while passing through the dielectric layer, thereby preventing damage to a target material including a living tissue.
  • the skin (scalp) region irradiated with the laser in the laser irradiation step S10 and the skin (scalp) region where the plasma is treated in the plasma processing step S20 are overlapped.
  • the hair growth promoting apparatus using the laser and the plasma according to the present embodiment includes a laser generator 200, a plasma generator 300, a power supply device 500, and a controller 600.
  • power is applied from the power supply device 500 to the controller 600, and the power applied to the controller 600 is controlled by the controller 600 and the plasma generator 200 and the plasma. It is electrically connected to the generator 300 to be applied.
  • the laser generating unit 200 is a peeling of various wavelengths (1500nm or more, 11000nm or less), including a CO 2 laser (wavelength 10600nm), Erbium Yag laser (Erbium YAG: wavelength 2940nm) and fractional laser (wavelength 1550nm). Sex lasers can be applied.
  • the laser generator 200 may be provided to generate a low power laser having a wavelength of 500nm or more, 700nm or less.
  • the laser generator 200 may be provided with a laser diode (LD) or a light emitting diode (LED) having a wavelength of 500 nm or more and 700 nm or less.
  • LD laser diode
  • LED light emitting diode
  • the skin reforming apparatus using the laser and the plasma of the present embodiment includes the handpiece body 100, the laser generator 200, the plasma generator 300, the bridge 400, the power supply device 500, and the controller 600. Include.
  • the plasma generator 300 is coupled to one end of the handpiece body 100, and the bridge 400 is formed to extend from the plasma generator 300 side end of the handpiece body 100.
  • the bridge 400 is coupled to the plasma generator 300.
  • the handpiece body 100 forms an outer shape of the present invention, has a cylindrical shape formed along the axial direction, and accommodates the power supply device 500 and the controller 600 therein.
  • the laser generator 200 is coupled to one end of the handpiece body 100 and includes a microarray lens (not shown).
  • the plasma generator 300 includes an electrode holder 310, a plasma electrode 330, and a spacer 350.
  • the plasma electrode 330 is seated inside the electrode holder 310, and the spacer 350 protrudes outward from the electrode holder 310.
  • the plasma generating unit 300 applies a dielectric barrier plasma, but is not limited thereto.
  • the plasma generator 300 includes a low temperature plasma using a streamer discharge, a dielectric barrier discharge, a creepage discharge, a corona discharge, or the like.
  • the electrode holder 310 is connected to one end of the bridge 400, is formed in a disk shape as a whole, it is formed in the shape of a hole so that the plasma electrode 330 can be seated inside.
  • the plasma electrode 330 includes a metal electrode 331, a dielectric layer 333, and a pinhole 335. On the other hand, the plasma electrode 330 is coupled to the electrode holder 310 to be detachable.
  • the metal electrode 331 is electrically connected to the power supply device 500 and the controller 600, and the surface of the metal electrode 331 is bonded to the dielectric layer 333 and covered.
  • the metal electrode 331 is formed in a lattice form.
  • the dielectric layer 333 is stacked on the metal electrode 331 with a uniform thickness. Accordingly, the metal electrode 331 is formed in the form of a lattice, and the pinhole 335 is formed between the dielectric layers 333 in the form of a lattice.
  • the dielectric layer 333 uses a ceramic material.
  • the dielectric layer 333 is not limited thereto, and alumina (Al 2 O 3 ), zirconia (ZrO 2 ), or the like may be used as the dielectric material.
  • the spacer 350 protrudes outward from the electrode holder 310 and is formed along the circumferential direction, and a plurality of spacers 350 are formed at predetermined intervals.
  • the spacer 350 is formed to be in contact with the user's skin.
  • four spacers 350 are formed at intervals of 90 degrees, but are not limited thereto.
  • the bridge 400 extends from an end portion of the laser generating unit side of the handpiece body 100 to be connected to the plasma generating unit 300.
  • two bridges 400 are formed, but are not limited thereto.
  • the bridge 400 is formed corresponding to the focal length of the laser generator 200.
  • FIGS. 4 and 5 the operation and effect of the apparatus for implementing the skin and scalp modification method using the laser and the plasma according to the present embodiment will be described.
  • a user grabs the handpiece body 100 and contacts the skin. Let's do it.
  • the spacer 350 is in contact with the skin to form a space between the plasma generating unit 300 and the skin.
  • the laser generator 200 may skin a laser having a wavelength of 500 nm or more and 700 nm or less in a laser diode (LD) or a light emitting diode (LED). Investigate (scalp).
  • LD laser diode
  • LED light emitting diode
  • the skin reforming apparatus using the laser and the plasma of the present invention when operated, power is applied to the metal electrode 331 of the plasma generating unit 300 through the power supply device 500 and the control unit 600. do.
  • the dielectric barrier plasma is generated, the power source uses a low frequency of 30 or more and 99 kHz or less for the dielectric barrier plasma processing, the power consumption of the plasma processing is 1 or more and 15 W or less, and the ground current of the plasma processing. Is not less than 0.1 and less than 9.9 mA, but is not limited thereto.
  • the power supply device 500 may supply an output current of a sin (sine) waveform (sine wave).
  • the output current waveform is obtained as a sin waveform
  • the efficiency compared to the input voltage can be further increased compared to a general square wave (square wave).
  • a square wave a surge phenomenon occurs, and when a plasma is generated, a large current flows rapidly for a short time, but the sin wave output has the advantage of enabling stable plasma.
  • plasma is generated by the potential difference between the plasma electrode 330 and the skin.
  • the energy generated by the potential difference in the metal electrode 331 is stabilized while passing through the dielectric layer 333 to prevent high energy from being concentrated at the localized portion. Therefore, the plasma is generated while passing through the dielectric layer 333 (dielectric barrier plasma) to prevent damage to the target material, including biological tissues.
  • the dielectric layer 333 is not formed only on one side thereof but is formed to surround the metal electrode 331, the plasma generation unit as well as the skin and the plasma generation unit 300 are separated from each other. Plasma is generated even when the skin side of 300 is in contact with the skin.
  • the metal electrode 331 and the dielectric layer 333 are formed in a lattice form to form the pinhole 335, and the laser generating unit 200 and the plasma generating unit are formed by the bridge 400. 300 was placed coaxially. That is, the skin region for irradiating a laser from the laser generator 200 and the skin region for generating plasma from the plasma generator 300 overlap each other.
  • the laser irradiated from the laser generator 200 may pass through the pinhole 335 to irradiate the skin.
  • the length of the bridge 400 may be formed to correspond to a laser focusing distance, thereby providing an optimal condition to prevent plasma damage while penetrating the plasma.
  • the plasma electrode 330 is detachably coupled, and designed to adjust the intensity of the plasma and the irradiation amount of the laser according to the type of skin.
  • control unit 600 not only operates the laser generator 200 and the plasma generator 300 at the same time, but also operates the laser generator 200 and then the plasma generator 300. ) May be operated, and conversely, the plasma generator 300 may be operated first.
  • the laser generating unit 200 and the plasma generating unit 300 may be alternately operated.
  • the laser generating unit 200 and the plasma generating unit 300 may be operated in accordance with a predetermined pattern.
  • VEGF vascular endothelial growth factor
  • the plasma treatment showed a doubling of VEGF expression compared to the case of no treatment.
  • the treatment of light only showed a slight difference in VEGF expression regardless of the wavelength of light. .
  • the wavelength of the light is blue (440 nm to 490 nm), green (485 nm to 555 nm), or yellow (570 nm to 610 nm).
  • the plasma and the red wavelength (605nm ⁇ 650nm) is treated together, it can be seen that the expression of VEGF significantly increased compared to all other cases.
  • plasma of various energies was combined with red wavelength light in human hair follicle dermal papilla cells.
  • Table 2 shows the results of% conversion of the MTT measurement results in each sample on the basis of the negative control group (plasma and light untreated), and the results of% conversion on the basis of untreated light in the same plasma energy group are shown in Table 3 below. Described.
  • the energy range of the plasma is preferably 5 to 40 J / cm 2 , more preferably 10 to 20 J / cm 2 .
  • the energy range of the plasma is preferably 5 to 20 J / cm 2 and the light of the red wavelength is 2 to 16 J / cm 2
  • the energy of the plasma is 10 to More preferably, the light of 20 J / cm 2 and the red wavelength is 2 to 16 J / cm 2
  • the energy range of the plasma is 10 to 20 J / cm 2 and the light of the red wavelength is 2 to 8 J / cm 2 .
  • the present invention relates to a device for modifying skin and scalp using a laser and a plasma, and to a method for modifying the plasma and the plasma according to the present invention, since hair growth from the scalp promotes hair growth and significantly increases the proliferation of dermal papilla cells. It is expected to be used greatly.

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Abstract

La présente invention concerne un procédé de modification de la peau au moyen d'un laser et d'un plasma et un appareil associé, l'appareil comprenant : un générateur laser configuré pour émettre un laser avec une puissance appliquée depuis un dispositif d'alimentation électrique ; et un générateur de plasma configuré pour recevoir une puissance provenant du dispositif d'alimentation électrique, pour générer une différence de potentiel, et générer ainsi un plasma. Dans l'appareil, le laser stimule la peau et le cuir chevelu tandis que le plasma pénètre dans la peau et le cuir chevelu stimulés, de façon à augmenter l'effet de régénération de la peau.
PCT/KR2017/012172 2016-10-31 2017-10-31 Appareil et procédé de modification de la peau au moyen d'un laser et d'un plasma WO2018080281A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR10-2016-0143693 2016-10-31
KR20160143694 2016-10-31
KR10-2016-0143694 2016-10-31
KR20160143693 2016-10-31
KR10-2017-0143710 2017-10-31
KR10-2017-0143711 2017-10-31
KR1020170143710A KR102002825B1 (ko) 2016-10-31 2017-10-31 발모 촉진장치
KR1020170143711A KR20180048397A (ko) 2016-10-31 2017-10-31 레이저와 플라즈마를 이용한 피부 및 두피 개질방법

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110787374A (zh) * 2018-08-01 2020-02-14 清华大学深圳研究生院 一种基于等离子体的促进毛发再生的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060127281A (ko) * 2005-06-07 2006-12-12 이송자 두발성장을 돕는 두피조직 활성화 캡
US20080228178A1 (en) * 2005-05-12 2008-09-18 Koninklijke Philips Electronics N.V. Hair-Growth Control Device and Hair-Growth Control Method
KR20150100457A (ko) * 2014-02-25 2015-09-02 한국전자통신연구원 광 및 플라즈마를 복합적으로 생성하는 방법 및 장치
KR101568380B1 (ko) * 2015-04-13 2015-11-12 주식회사 서린메디케어 플라즈마를 이용한 피부 치료 장치
KR101620840B1 (ko) * 2007-11-23 2016-05-13 (주)프로스테믹스 고출력 프락셔날 레이저 및 고압의 온도를 높인 식염수 분사방식을 이용한 발모 촉진 방법 및 장치
KR20160072759A (ko) * 2014-12-15 2016-06-23 (주)와이에스 저온 플라즈마를 이용한 휴대용 피부 미용기

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080228178A1 (en) * 2005-05-12 2008-09-18 Koninklijke Philips Electronics N.V. Hair-Growth Control Device and Hair-Growth Control Method
KR20060127281A (ko) * 2005-06-07 2006-12-12 이송자 두발성장을 돕는 두피조직 활성화 캡
KR101620840B1 (ko) * 2007-11-23 2016-05-13 (주)프로스테믹스 고출력 프락셔날 레이저 및 고압의 온도를 높인 식염수 분사방식을 이용한 발모 촉진 방법 및 장치
KR20150100457A (ko) * 2014-02-25 2015-09-02 한국전자통신연구원 광 및 플라즈마를 복합적으로 생성하는 방법 및 장치
KR20160072759A (ko) * 2014-12-15 2016-06-23 (주)와이에스 저온 플라즈마를 이용한 휴대용 피부 미용기
KR101568380B1 (ko) * 2015-04-13 2015-11-12 주식회사 서린메디케어 플라즈마를 이용한 피부 치료 장치

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110787374A (zh) * 2018-08-01 2020-02-14 清华大学深圳研究生院 一种基于等离子体的促进毛发再生的方法

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