WO2020204224A1 - Appareil de procédure complexe pour favoriser l'administration transdermique - Google Patents

Appareil de procédure complexe pour favoriser l'administration transdermique Download PDF

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Publication number
WO2020204224A1
WO2020204224A1 PCT/KR2019/003859 KR2019003859W WO2020204224A1 WO 2020204224 A1 WO2020204224 A1 WO 2020204224A1 KR 2019003859 W KR2019003859 W KR 2019003859W WO 2020204224 A1 WO2020204224 A1 WO 2020204224A1
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WIPO (PCT)
Prior art keywords
skin
unit
transdermal delivery
plasma
electrode
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PCT/KR2019/003859
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English (en)
Korean (ko)
Inventor
이진우
Original Assignee
주식회사 하이로닉
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Publication of WO2020204224A1 publication Critical patent/WO2020204224A1/fr

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    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/20—Additional enhancing means
    • A45D2200/202—Ionisation
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/20—Additional enhancing means
    • A45D2200/207—Vibration, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0034—Skin treatment

Definitions

  • the present invention relates to a complex surgical apparatus for promoting transdermal delivery, and more specifically, to a complex apparatus for promoting transdermal delivery capable of increasing the penetration rate, flow rate, and absorption rate of drugs into the skin using plasma and ultrasound. will be.
  • the stratum corneum of the skin acts as a barrier not only against external pollutants or harmful substances, but also against skin care or therapeutic drugs, making penetration difficult.
  • Skin care or therapeutic drugs are slightly absorbed in the stratum corneum, but their absorption rate is very slow, so a long treatment time and a high dosage are required.
  • Technologies for facilitating transdermal delivery can be broadly classified into two categories, one to increase the permeability of the skin and the other to improve the flow rate in the skin.
  • a technique of applying an electric shock to the skin is used, and as a method of improving the flow rate, an energy gradient is created in the skin to move the active ingredient under the stratum corneum to increase transdermal flow.
  • the present invention creates a complex treatment device capable of improving the flow rate and absorption rate as well as the skin penetration rate of the drug, keeping the skin clean by sterilizing function, and simultaneously performing various skin beauty functions in combination to maximize the skin beauty effect. It is to provide a complex surgical device for facilitating transdermal delivery.
  • a combined treatment apparatus for promoting transdermal delivery including a plasma generation unit that generates plasma by a high voltage and sprays the skin on the skin, and an ultrasound generation unit that generates ultrasound and transmits ultrasound energy to the skin tissue.
  • the complex surgical apparatus for promoting transdermal delivery may further include a first handpiece capable of being gripped by a practitioner and having a plasma generating unit installed on one side thereof, and a second handpiece capable of being gripped by a practitioner and having an ultrasound generation unit installed on one side.
  • the complex surgical apparatus for promoting transdermal delivery may further include a main body providing power to the plasma generating unit and the ultrasonic generating unit, and a mounting unit installed on the main body to mount the first handpiece and the second handpiece.
  • the composite treatment apparatus for promoting transdermal delivery may further include a display unit formed in the main body to indicate whether the plasma generating unit and the ultrasonic generating unit are operated.
  • the plasma generating unit may include at least one electrode and a patterned dielectric unit disposed between the electrode and the skin.
  • the pattern-type dielectric portion has a shape of any one of a stripe type, a mesh type, a grid type, a comb type, a honeycomb type, and a slit type, and has a ridge of any one shape of a hemispherical shape, a square column shape, a pyramid shape, and a polygonal column shape. I can.
  • the electrode of the plasma generating unit may be formed of any one of a mesh electrode, a grid electrode, a comb electrode, and a slit electrode.
  • the complex surgical apparatus for promoting transdermal delivery may further include an iontophoretic unit having a plurality of electrodes spaced apart on the skin so that a microcurrent flows through the skin by applying at least one of a voltage signal and a current signal to the skin.
  • the complex surgical apparatus for promoting transdermal delivery may further include an electroporation electrode unit that emits pulses forming microchannels in the skin.
  • the complex procedure device for promoting transdermal delivery may further include a drug applicator for applying cosmetics or drugs contained in a container to the skin.
  • the complex treatment apparatus for promoting transdermal delivery may further include an ozone filter for removing residual ozone in the plasma generating unit.
  • the ozone filter is configured to be fitted and fixed inside the plasma generating unit or outside the housing, and a photocatalyst for reducing ozone to oxygen may be coated.
  • the complex treatment apparatus for promoting transdermal delivery may further include a moisture removal unit provided at one side of the plasma generating unit to remove moisture in the plasma space.
  • the complex surgical apparatus for promoting transdermal delivery may further include a protective cap installed on the first handpiece to cover the plasma generating unit.
  • the protective cap includes a plurality of through holes formed in the protective cap so that plasma generated by the plasma generating unit can be transmitted to the skin, and the plurality of through holes may be radially disposed from the center of a surface in contact with the skin.
  • collagen synthesis can be promoted by plasma, thereby providing an effect of improving skin wrinkles and elasticity, maximizing the penetration of active ingredients such as skin moisturizing, and anti-aging effect and skin It can provide a management effect.
  • FIG. 1 is a perspective view showing a complex procedure device for promoting transdermal delivery according to an embodiment of the present invention.
  • Figure 2 is a perspective view of a first handpiece and a second handpiece showing a complex procedure device for promoting transdermal delivery according to an embodiment of the present invention.
  • FIG. 3 is a view showing a complex procedure device for promoting transdermal delivery according to an embodiment of the present invention.
  • Figure 4 is a perspective view showing a complex treatment device for promoting cart-type transdermal delivery according to another embodiment of the present invention.
  • Figure 5 is a perspective view showing a complex procedure device for promoting portable transdermal delivery according to another embodiment of the present invention.
  • FIG. 6 is a cross-sectional view showing a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention.
  • FIG. 7 and 8 are perspective views showing the rear surface of the pattern-type dielectric part of the plasma generating part of the complex treatment apparatus for promoting cart-type transdermal delivery according to another embodiment of the present invention.
  • 9 to 11 are cross-sectional configuration diagrams showing a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention.
  • FIG. 12 is a perspective view showing a complex procedure device for promoting portable transdermal delivery according to another embodiment of the present invention.
  • FIG. 13 is a cross-sectional view showing a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention.
  • FIG. 14 is a block diagram showing a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention.
  • 15 is a view showing a handpiece connector of a complex procedure device for promoting transdermal delivery according to an embodiment of the present invention.
  • 16 is a view showing the experimental results of a complex procedure device for promoting transdermal delivery according to an embodiment of the present invention.
  • skin refers to a tissue covering the body surface of humans and animals, and is the broadest concept including all tissues covering the body surface of the body such as a face, fingers, toes, as well as scalp and hair.
  • skin active ingredient refers to an active ingredient provided for therapeutic or cosmetic purposes to the skin or scalp.
  • the skin active ingredient includes those having a pure charge of either positive or negative charges.
  • the word “skin active ingredient” is used interchangeably with the word “drug”.
  • FIG. 1 is a perspective view of a complex surgical device for promoting transdermal delivery according to an embodiment of the present invention
  • FIG. 2 is a first handpiece 1100 and a second handpiece 1200 of a complex surgical apparatus for promoting transdermal delivery. Is a perspective view of.
  • the complex procedure device for promoting transdermal delivery of the embodiment shown in FIGS. 1 and 2 may be used in a dermatology or skin care shop, and a plasma generating unit 100 and an ultrasonic generator 300 that are easy to carry are installed. Convenience may be provided to a user through a plurality of handpieces.
  • the complex treatment apparatus for promoting transdermal delivery includes a plasma generating unit 100 that generates plasma by high voltage and sprays it on the skin, and an ultrasonic generator 300 that generates ultrasonic waves to deliver ultrasonic energy to skin tissue. Including, it is possible to stimulate the skin using plasma and ultrasound to promote transdermal delivery of drugs.
  • the main body 1000 shown in FIG. 1 forms a space therein, and in the space formed inside the main body 1000, a power supply unit 600 providing power to the plasma generating unit 100 and the ultrasonic generating unit 300 Can accommodate.
  • a handpiece connector 1300 capable of coupling the main body and the first handpiece 1100 and the second handpiece 1200 to be described later may be installed on the rear surface of the main body 1000.
  • the handpiece connector 1300 may be provided with a plurality of insertion grooves into which a plurality of electrode pins formed at the ends of the connection lines coupled to the handpieces 1100 and 1200 can be inserted, and the plurality of insertion grooves may include a plurality of electrodes. It may be arranged to correspond to the pin.
  • the plurality of electrode pins of the first handpiece 1100 and the plurality of electrode pins of the second handpiece 1200 of the present embodiment may be formed in different arrangements. Accordingly, the main body has a different arrangement.
  • a plurality of handpiece connectors 1300 in which insertion grooves are formed may be installed.
  • the insertion groove of one handpiece connector 1300 may be disposed along the edge of a rhombus having the same length on all four sides, and the insertion groove of the other handpiece connector 1300 has a circular edge. Can be arranged accordingly. Therefore, the first handpiece 1100 and the second handpiece 1200 may be connected to match each other to the handpiece connector 1300 constituting the insertion groove having a different arrangement, so that the handpiece connector 1300 that does not match each other It can prevent mis-connected to.
  • the plasma generating unit 100 and the ultrasonic generating unit 300 may be installed on different handpieces, respectively, and more specifically, a plasma generating unit on one side of the first handpiece 1100 ( 100) may be installed and an ultrasonic generator 300 may be installed on one side of the second handpiece 1200. Specific parts of the plasma generating unit 100 and the ultrasonic generating unit 300 of the present embodiment will be described later.
  • the mounting portion 1010 shown in FIG. 1 may be installed on the main body 1000 so that the first handpiece 1100 and the second handpiece 1200 can be mounted, and the first handpiece 1100 and the second A mounting space corresponding to the shape of the handpiece 1200 is formed, and more specifically, the mounting portion 1010 is installed in the body 1000 so that one side faces downward, and one side of the mounting portion 1010 is The 1 handpiece 1100 and the second handpiece 1200 may be supported.
  • one side of the first handpiece 1100 and the second handpiece 1200 in the longitudinal direction and the other side of the first handpiece 1100 and the second handpiece 1200 may be mounted irrespective of the one side of the mounting portion 1010, thereby providing convenience to the user.
  • a protective cap may be installed to cover the plasma generating unit 100 installed on one side of the first handpiece 1100, and transmitted to the plasma generating unit 100 by the protective cap It can prevent impact or contamination.
  • the protective cap 1110 may have a plurality of through holes so that the plasma generated by the plasma generating unit 100 can be transmitted to the skin, and more specifically, the protective cap 1110 The formed through-holes may be disposed radially from the center of the surface in contact with the skin. In addition, the protective cap 1110 may be formed in a thin thickness, for example, 0.4 to 0.8 mm for stable plasma radiation.
  • the display unit is installed on the main body 1000 to display the current operating state of the plasma generation unit 100 and the ultrasonic generation unit 300, and further, the display unit is formed as a touch-operable display unit.
  • the function, intensity, and operation of the plasma generating unit 100 and the ultrasonic generating unit 300 can be easily adjusted according to the type or condition of the skin.
  • Figure 4 is a perspective view of a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention
  • Figure 5 is a perspective view of a portable device for promoting transdermal delivery according to another embodiment of the present invention
  • Figure 6 Fig. 5 is a schematic cross-sectional configuration diagram of a complex surgical apparatus for promoting a portable transdermal delivery according to another embodiment of the present invention
  • FIG. 7 is a plasma generation of a complex apparatus for promoting transdermal delivery according to another embodiment of the present invention It is a perspective view of the back side of a negative pattern-type dielectric part.
  • the complex treatment device of the present invention is implemented as a cart type as shown in FIG. 4 or a portable complex treatment device capable of hand carry by integrating a complex management function that can be held and used by a user as shown in FIG. 5 Can be implemented as
  • the handpiece separately connected to the main body in FIG. 4 generates plasma by a high voltage and sprays it onto the skin, and iontophoresis in a method of flowing a microcurrent to facilitate drug penetration.
  • FIG. 5 a structure including a plasma generating unit 100 and an iontophoretic unit 200 is shown in an exemplary embodiment of a portable complex surgical apparatus in which a main body and a handpiece are integrated.
  • the cart-type complex treatment device shown in FIG. 4 may be approved as a medical device and used in a hospital by an expert (doctor) for the treatment of conditions such as atopy or used in a beauty management room by adjusting specifications. ) Or some of the iontophoresis unit 32 may be replaced, or other complex procedures may be formed in addition to the function.
  • the handpieces 30 and 15 that can be detachably connected to the main body may be used as a single handpiece by mounting a plurality of functions as shown, or may be installed in plural and utilized so that they can be used simultaneously for multiple subjects or target areas. .
  • the handpieces 30 and 15 When a plurality of handpieces 30 and 15 configured differently for each use are configured, they may be connected to the body in advance and selected and used according to the skin condition of the target site or the judgment of the operator.
  • the handpieces 30 and 15 may be configured to be connected in a detachable or permanent attachment type, and may be used in a Bluetooth method by removing the connection part 17.
  • the main body 18 may be additionally configured with a display unit 12 capable of visually showing a procedure guide or data or a skin condition to the user.
  • the user input unit may be integrally coupled to the display unit 12 to be provided in the form of, for example, a touch pad, or may be provided as a separate user interface unit 13.
  • the operator may directly select a desired function, perform data analysis according to a skin type or input condition, or may be recommended conditions for treatment according to a preset matching value.
  • the plasma generating unit 100 and the iontophoretic unit 200 are formed in a housing (or case) 21 that can be held by the consumer directly and used for self-management at home.
  • the portable complex treatment device 20 includes a head in which the plasma generating unit 100 and the iontophoretic unit 200 are formed in a housing or case 21, a rechargeable battery (not shown) supplied with an available voltage from the outside, and supplied from the battery.
  • a high voltage supply module (not shown) that outputs DC power as AC power, buttons 24 for selecting an on/off switch or mode, and optionally a display unit 23 may be included.
  • a soothing portion 22 capable of low-temperature treatment capable of soothing the skin may be formed on the opposite side of the head.
  • FIG. 6 is a cross-sectional view of a complex surgical apparatus for promoting transdermal delivery according to another embodiment of the present invention, and a power supply unit 610 and a control unit inside the apparatus housing 21 including the plasma generating unit 100 and the iontophoretic unit 200 500 and a high voltage generator 620 are installed.
  • the iontophoresis unit 200 applies at least one of a voltage signal and a current signal to the skin to allow microcurrent to flow through the skin to facilitate transdermal delivery of the drug.
  • electrodes 210 and 220 are provided on the skin. It may include spaced apart structures.
  • the plasma generating unit 100 in FIGS. 4 to 6 includes an electrode unit 110 for generating a voltage for generating plasma and a dielectric unit 140 for directly forming a plasma, and the dielectric unit 140 Can be implemented in various types of structures as shown in FIG. 7.
  • a separating member structure for maintaining a gap with the skin may be additionally formed at an appropriate position such as around or in the center of the dielectric part 140 by using a plastic cover with a separate through part.
  • the plasma generation unit 100 of the complex treatment apparatus of the present invention is an atmospheric pressure plasma generation device that generates plasma without separate gas inflow, and has a dielectric barrier discharge (DBD) type to prevent the transition to arc plasma.
  • DBD dielectric barrier discharge
  • dielectric barrier discharge is a method of installing a dielectric barrier on two electrodes or one or more electrodes in a pair and using a dielectric polarization phenomenon, and a reverse potential is formed due to charge accumulation, thereby stopping the discharge.
  • This is a method that prevents the conversion from pulse discharge to arc discharge.
  • Dielectric barrier discharge can obtain relatively uniform plasma, can generate large-area plasma, and do not use other gases such as helium or argon. Therefore, the plasma generating unit 100 includes two or more electrodes 110 to which a high voltage is applied and dielectric units 130 and 140 between the electrodes, and plasma is generated between the electrode and the skin surface by dielectric barrier discharge. Is configured to occur.
  • Atmospheric pressure plasma generated by the plasma generating unit 100 is generated by a strong electric field between the electrode and the insulator, and oxygen, hydrogen, moisture, nitrogen, etc. in the air are ionized and various active species such as ozone, O, O2-, etc. Are produced in large quantities. These various active species have a strong sterilization effect by destroying the cell walls of bacteria without affecting the living tissues, and periodic treatment of plasma on the skin stimulates skin cells to increase collagen in the dermal layer, and vascular endothelial cells Due to the increased secretion of growth factor (VEGF), new blood vessels may provide nutrients to skin cells, thereby providing anti-aging effects.
  • VEGF growth factor
  • One of the two or more electrodes 110 is a power electrode (not shown) connected to the power supply, and the other is a plasma electrode 110 that generates plasma on the skin side.
  • the plasma electrode 110 may be a mesh electrode, a grid electrode, a comb type, a honeycomb type, or a slit type electrode capable of lowering a discharge voltage.
  • the geometric shape of the plasma electrode 110 is variously configured to narrow the distance between electrodes and increase the number of electrode arrays per unit area to form a dense electrode, thereby obtaining a low-power, high-density plasma. The narrower the gap between the electrodes, the higher the density plasma discharge can be obtained even if the applied voltage is low.
  • the electrodes 110 may be formed of a conductive material or may be formed by coating an insulating material with a conductive material.
  • the electrodes may have an arbitrary shape such as a circular or square cross section.
  • a method of coating the dielectric part 130 around the electrode is not particularly limited, but may be coated by, for example, screen printing, spin coating, or dip coating.
  • the dielectric unit 140 may be disposed between the power electrode (not shown) and the plasma electrode 110 or may be formed on one surface of the plasma electrode 110 in contact with the skin side or with a space apart from the electrode unit, Plasma is formed in the space by forming to have a certain distance from the skin of the person to be treated.
  • the dielectric part 140 may be formed by coating the dielectric parts 130 and 140 on the plasma electrode 110 by coating an electrode electrode as well as one surface of the electrode.
  • the dielectric part 140 between the electrode and the skin has a mesh-like pattern or an embossed three-dimensional pattern as shown in FIG. 7. It may be formed as a patterned dielectric part. That is, it may be formed in a stripe shape as shown in FIG. 7(a) or a mesh shape or a grid shape as shown in FIG. 7(b), and may be configured in a comb type, honeycomb type, or slit type.
  • a raised part 141 having a microstructure similar to a plurality of protrusions by a three-dimensional pattern is formed in a set portion such as a peripheral circumference or a central part, thereby forming a separate space maintaining part or a spacer.
  • a plastic cover provided with a separate through-hole for a space maintaining a space between the skin and the dielectric part 140 is formed on the top of the dielectric part 140 to be additionally detachable, thereby creating a space between the skin and the dielectric part 140.
  • Plasma may be formed by providing.
  • the shape of the raised portion 141 of the dielectric portion 140 is a structure such as a hemispherical shape, a square column shape, a pyramid shape, a polygonal column shape, and a cone shape, as shown in FIGS. 7(c)-(f). It may have, but is not necessarily limited to this shape.
  • the protruding height of the raised portion 141 is correlated with the amount of power for plasma formation.
  • the method of manufacturing the patterned dielectric part 140 having such a three-dimensional pattern is not particularly limited.
  • the pattern-type dielectric part 140 may form a desired pattern using a printing technique, and a more precise pattern may be formed using a photolithography technique.
  • the patterned dielectric part 140 may be formed by using a vapor deposition method such as an electron beam vapor deposition method, a resistance heating vapor deposition method, and a high frequency induction heating deposition method, and in addition, a pattern type dielectric part 140 may be formed by any method known in the art.
  • the dielectric part 140 may be formed.
  • the pattern-type dielectric part 140 can radiate a higher density plasma by minimizing the space between the respective dielectric parts 140, and more specifically, the pattern-type dielectric part 140
  • the portion 140 is formed in a shape in which adjacent surfaces of each of the dielectric portions 140 correspond to each other, such as a square, so that the space between the dielectric portions 140 can be minimized (see FIG. 12).
  • the dielectric parts 130 and 140 may be made of a hard material or a flexible material.
  • the hard material may be made of a material such as a polymer film such as quartz, sapphire, glass, ceramic, polytetrafluoroethylene, polyvinylidene fluoride, polycarbonate, and polypropylene.
  • a flexible material a silicone compound, Synthetic rubber, polyurethane, or polyethylene can be used.
  • the dielectric parts 130 and 140 may be manufactured by coating a conductor with an insulating material or plating with an insulating material.
  • the plasma generating unit 100 fills between the parallel plate electrodes with a dielectric having a large relative permittivity ( ⁇ ), and forms a dielectric thin film to reduce the dielectric thickness (d) to calculate the capacitance (C).
  • ⁇ a dielectric having a large relative permittivity
  • d dielectric thickness
  • C capacitance
  • a large output power value (W) can be formed without electrical shock on the skin, so that a desired plasma amount can be obtained while preventing an electric shock from occurring on the skin.
  • W output power value
  • the dielectric thickness d is applied using a material having a high dielectric constant, the d value can be applied small, and the dielectric portion 142 having a small size can be formed as a whole.
  • W power consumption [W]
  • f driving frequency [Hz]
  • K relative dielectric constant
  • A electrode area [m2]
  • d distance between electrodes [m]
  • the electrode 111 is formed in a shape in which protruding portions alternately exist in the xy-axis direction so that there is no electrical shock to one part of the skin when plasma is formed in each of the dielectric portions 142,
  • the portion 142 is formed to secure a space for plasma discharge between the dielectric portions 142 in the xy column direction.
  • the dielectric portion 142 is formed only on the protruding portion of the electrode 111 (see FIG. 8(a)), or formed on the entire surface of the electrode 111 (see FIG. 8(b)), or FIG. 8(c) As such, it may be formed only on the surface of the protrusion and the surface between the protrusions.
  • a separate shielding film may be formed between the dielectric parts 142 to form a plasma discharge.
  • the power supply unit 600 includes a power supply unit 610 corresponding to a commercial power supply or a battery, and a high voltage generation unit 62 that generates a high voltage using DC power from the power supply unit 610.
  • the power supply unit 610 is embedded in the body or at one side of the housing, converts a voltage input from a general commercial power source or battery into a voltage for driving the iontophoresis unit, and the power supply unit 600 converts the voltage After receiving the supplied and outputting a control voltage (pulse), the control voltage is converted into a high voltage and supplied to the power electrode 110 of the plasma generating unit 100.
  • the power supply unit 600 may be configured to convert the input power into a DC high voltage, and then convert the DC high voltage into a pulse high voltage of a predetermined period and output it.
  • an output power of about 0.1W to 3W is preferable.
  • the size of the output power can be adjusted according to the purpose of use, such as sterilization, skin irritation, and skin regeneration.
  • the input is AC 220V, 50 to 60 Hz
  • the output voltage is 0.8 to 7 kV
  • the output voltage frequency range is about 10 kHz to 30 kHz, preferably Design it at about 20kHz.
  • the control unit 500 of the skin treatment apparatus using plasma according to the present invention supplies DC power output from the power supply unit 610 to the high voltage generator 620 and controls it to be converted into high frequency and high voltage AC power.
  • the power supply unit 600 may further include an output control means (not shown) for adjusting high-pressure output.
  • the iontophoresis unit 200 at least one of a voltage signal and a current signal is applied across the electrodes 210 and 220 having a conductive path to generate an iontophoretic force on the charged skin active ingredients. As the force tries to move the active ingredients of the skin towards an electrode with opposite polarity, active transport of the drug in the electric field takes place. Whether the skin active ingredient is positively or negatively charged, the iontophoretic unit 200 may be configured to apply an appropriate polarity and current to drive a specific skin active ingredient into the skin.
  • the iontophoretic unit 200 applies an ionic material having a positive characteristic to the'+' electrode in order to use a repulsive force acting between charges of the same polarity, and an ionic material having a negative characteristic is applied to the'-' electrode. So that the ionic substance easily penetrates the skin.
  • the iontophoresis unit 200 may function to flow a fine current through the head and may be in a form of adjusting the intensity of the fine current flowing through the head to various levels.
  • the first electrode and the second electrode must be spaced apart from each other and contact the user's skin.
  • the second electrode may be mounted on or embedded within the housing.
  • the second electrode may be configured to conduct electricity with the user's skin through the user's hand holding the housing of the portable device.
  • both electrodes are used by the subject to hold the iontophoresis unit 200 by hand. It can be configured to contact the user's skin without work.
  • the second electrode may contact the user's skin in the form of a pad or the like.
  • the electrode 210 of the iontophoresis unit 200 may include an ion exchange membrane composed of a porous film and an ion exchange resin filled in a plurality of holes in the porous film.
  • the iontophoretic unit 200 may include an ion exchange membrane for selecting ions having the same polarity as the ions of the charged drug.
  • the iontophoretic unit 200 is a porous film made of a material such as polyolefin, vinyl chloride resin, or fluorine resin in order to facilitate passage of drug ions having a relatively high molecular weight and effectively suppress the release of counter ions from the skin.
  • a type of ion exchange membrane filled with an ion exchange resin can be used.
  • the electrode 210 of the iontophoresis unit 200 may be an electrode made of any conductive material without particular limitation, but in particular, an inert electrode made of carbon, platinum, etc. may be preferably used, and the elution of metal ions, And a carbon electrode that does not have any concern about its migration to a living body can be used more preferably.
  • the control unit 500 may include a microprocessor in which data related to iontophoretic properties of a specific drug administered through the iontophoretic unit 200 is embedded. The data may include correlations with these conditions and delivery rates when a specific drug is delivered to the body through the skin by the iontophoresis unit 200 under specific current and/or ion flow conditions.
  • the control unit 500 may be configured to adjust the intensity of the current supplied to the user's skin by the iontophoresis unit 200.
  • the intensity of the current does not necessarily need to be automatically adjusted, and may be capable of adjusting the intensity of the current according to the user or the operator's decision or necessity.
  • control unit 500 may be configured to automatically turn on/off the current supplied to the user's skin by the iontophoresis unit 200 at a set time interval.
  • the iontophoretic unit 200 applies a voltage having the same polarity as that of the drug ions while the first electrode and the second electrode are in contact with the skin, so that the drug ions penetrate into the skin.
  • the current supplied to the electrode 210 of the iontophoresis unit 200 may be a direct current or an alternating current in the form of a sine wave or a square wave.
  • the plasma generating unit 100 and the iontophoretic unit 200 may be connected in various ways.
  • the plasma generating unit 100 and the iontophoretic unit 200 may be disposed adjacent to each other in a direction parallel to the skin surface, as shown in FIG. 5.
  • a drug may be applied and iontophoresis may be performed, or plasma treatment and iontophoresis may be simultaneously performed.
  • the plasma generating unit 100 and the iontophoretic unit 200 may be activated simultaneously or sequentially at a time difference under the control of the controller.
  • the plasma generating unit 100 is formed as a cap mounted on the iontophoretic unit 200, and in the case of plasma treatment, the cap-shaped plasma generating unit 100 is used as an iontophoretic unit.
  • the treatment can be performed by putting the treatment on 200, and after the plasma treatment, the cap on which the plasma generating part is formed is removed and the iontophoretic part 200 is activated.
  • the complex procedure device for promoting transdermal delivery of the present invention may further include an ultrasonic generator 300 that transmits ultrasonic energy to skin tissue.
  • the ultrasonic generator 300 is operated by a control signal from the controller 500 to output ultrasonic waves exceeding about 18,000 Hz.
  • the ultrasonic stimulation generated by the ultrasonic generator 300 serves to stimulate the skin, strengthen muscles, increase elasticity, and accelerate the supply of nutrients within the tissue.
  • Providing low-frequency ultrasound coupled to the skin through a cream or gel-type cosmetic composition or a bad agent can increase the transdermal flow of the active ingredients.
  • the increase in kinetic energy by ultrasound causes reversible cleavage of intracellular lipid bilayers in the stratum corneum, allowing larger, more complex or hydrophilic molecules to effectively penetrate the skin.
  • the composite treatment apparatus of the present invention may further include an electroporation electrode part 400 that emits pulses forming microchannels in the skin.
  • the electroporation electrode unit 400 is composed of two electroporation electrodes having different polarities from each other, and these electrodes are connected to the control unit 500 and the power supply unit 610 for controlling a voltage applied to the electroporation electrodes.
  • the electrodes of the electroporation electrode unit 400 are arranged to be in contact with the skin, and when electricity is applied by the power supply unit 610 in a state in contact with the skin, the electroporation pulse is transmitted to the skin cells to increase the permeability of the lipid bilayers. Temporarily increase it.
  • the electroporation electrode unit 400 reversibly forms micropores in the lipid bilayers by generating short bursts of relatively high voltage electric fields, and allows skin active ingredients to enter the skin through these micropores. To be. Both intracellular and intercellular pathways for the delivery of skin active ingredients are formed by electroporation.
  • the complex treatment apparatus for promoting transdermal delivery of the present invention includes a plasma generation unit 100 in the main body, The iontophoresis unit 200, the ultrasonic generator 300, and the control unit 500 that controls the operation between the electroporation electrode unit 400, the power supply unit 600 supplying power to each unit, the user's input And receiving user interface units 12 and 13, and the like.
  • the control unit 500 operates between the plasma generation unit 100, the iontophoresis unit 200, the ultrasonic generator 300, the electroporation electrode unit 400, the power supply unit 500, and the user interface 12, 13 Can be controlled.
  • the control unit 500 may control the plasma generation unit, the ultrasonic generation unit, the iontophoresis unit, and the electroporation electrode unit to operate simultaneously or sequentially. For example, when the electroporation electrode unit or the iontophoresis unit is activated, the operation of the plasma generation unit or the ultrasonic generation unit may be stopped, and when the plasma generation unit or the ultrasonic generation unit is activated, the operation of the electroporation electrode unit or the iontophoresis unit may be stopped.
  • the complex treatment apparatus of the present invention may further include a display unit 12 and a communication unit (not shown) electrically connected to the control unit.
  • the display unit 12 may display the amount, speed, treatment mode, and current intensity of a drug administered under a specific condition included in the control unit 500.
  • the display unit 12 includes any display device known in the art.
  • the control unit 500 may include some of an image processing unit, a communication unit, and a memory unit, but is not limited to this implementation.
  • some or all of the image processing unit, the communication unit, the memory, the user interface unit, and the control unit may be operated by a software module, but is not limited thereto, and some of the above-described components may be operated by hardware.
  • the user interface units 12 and 13 generate input data that the user inputs to control the operation of the complex treatment device for promoting transdermal delivery.
  • the user interface units 12 and 13 may include hardware configurations such as a keypad, a mouse, a touch pad, a trackball, a jog switch, etc., but are not limited thereto, and a voice recognition sensor, a gesture recognition sensor, a fingerprint recognition sensor, an iris recognition sensor, etc. It may further include various configurations of.
  • the complex procedure device for promoting transdermal delivery may display a control panel of the device on the touch screen of the display unit 12.
  • a mode selection unit for inputting which one of a plasma generation unit, an ultrasound generation unit, an iontophoresis unit, and an electroporation electrode to be activated may be formed in the user interface unit of the complex treatment apparatus of the present invention.
  • the complex surgical apparatus for promoting transdermal delivery of the present invention may be implemented in a miniaturized portable type as shown in FIG. 5.
  • the power supply 610 may be a battery
  • the present invention can be used as a miniaturized portable.
  • a head having a plasma generating unit, an ultrasonic generating unit, an iontophoretic unit, and an electroporation electrode unit, a control unit, and a power supply unit may be disposed in the case or housing.
  • the case is made of an insulating material and may be in the shape of a circular or square pillar.
  • the case may be fixed in combination with a ground electrode of a plasma generating unit, an ultrasonic generator, an iontophoretic unit, and an electroporation electrode unit, and the ground electrode 101 may be grounded by a user's hand.
  • the battery can be charged by receiving power from an external power source. Also, the battery may supply a DC voltage to the high voltage generator 620.
  • the complex treatment apparatus of the present invention may further include an interference blocking unit (not shown) for preventing interference caused by electromagnetic waves between the plasma generation unit, the ultrasonic generation unit, the iontophoresis unit, and the electroporation electrode unit.
  • an interference blocking unit for preventing interference caused by electromagnetic waves between the plasma generation unit, the ultrasonic generation unit, the iontophoresis unit, and the electroporation electrode unit.
  • the composite treatment apparatus may further include an ozone filter 150 for removing ozone generated from plasma and excessively formed beyond a required concentration.
  • an ozone filter 150 for removing ozone generated from plasma and excessively formed beyond a required concentration.
  • Ozone has a problem of lowering the feeling of use due to a fishy odor.
  • the ozone filter 150 may be configured to be fitted and fixed inside the head or outside of the housing, and disposed to be exchangeable. Can be.
  • the ozone filter 150 is a filter that adsorbs and removes ozone by passing ozone through porous activated carbons using an adsorbent such as activated carbon or silicon nanowires, or a prefilter or carbon filter that is easy to replace a mesh. It may be a chlorine atom that is decomposed and reduced to oxygen, or a filter coated with a photocatalyst.
  • FIG. 10 is a schematic cross-sectional view of another complex procedure device of the present invention.
  • a dust collector 800 for treating the ozone may further include.
  • the dust collector 800 may be installed in the housing 21 to collect residual amount of ozone, and discharge the collected ozone to a safe place through a duct 801 or the like.
  • the present invention may be provided with a moisture removal unit 900 for absorbing moisture in the atmosphere, respectively, at the front and rear of the plasma generating unit.
  • the moisture removal unit 900 absorbs moisture in the plasma space, thereby preventing erroneous discharge from occurring in the electrode of the plasma generation unit.
  • the moisture removing unit 800 may be implemented with a sponge or a moisture absorbing paper roller, and a moisture removing unit 900 may be installed around the periphery of the plasma generating unit 100 with a sponge to remove moisture.
  • a moisture removing unit 900 may be installed around the periphery of the plasma generating unit 100 with a sponge to remove moisture.
  • it is not limited to this configuration, and may be configured to remove moisture by other known techniques capable of removing moisture.
  • Another aspect of the present invention is a plasma generating unit 100 that generates plasma by high voltage and sprays it on the skin, and is provided at one side of the plasma generating unit 100 to apply cosmetics or drugs contained in a container to the skin. It relates to a complex treatment device for promoting transdermal delivery, characterized in that it comprises a drug applicator 700.
  • the drug applicator is a drug applicator 700 including a ball that is partially exposed and rotatably installed at an end contacting the skin of the container body, or a drug applicator configured to apply a drug to the skin by an actuator or compressed gas It may be 700.
  • the plasma generating unit may include a patterned dielectric unit 140 disposed between the electrode and the skin.
  • the patterned dielectric part 140 may have a stripe type, a mesh type, a grid type, a comb type, a honeycomb type, or a slit type, or have a hemispherical shape, a square column shape, a pyramid shape, and a polygonal column shape.
  • Another embodiment of the present invention is a plasma generating unit 100 that generates plasma by a high voltage in a plasma space between the skin and the dielectric unit 140 and sprays it on the skin, and one side of the plasma generating unit 100 It relates to a complex treatment apparatus for promoting transdermal delivery, characterized in that it includes a moisture removal unit for removing moisture in the plasma space.
  • the plasma generating unit 100 may include a patterned dielectric unit 140 disposed between the electrode and the skin.
  • the patterned dielectric part 140 may have a stripe type, a mesh type, a grid type, a comb type, a honeycomb type, or a slit type, or have a hemispherical shape, a square column shape, a pyramid shape, and a polygonal column shape.
  • FIG. 11 is a schematic cross-sectional configuration diagram of another complex procedure device of the present invention.
  • the complex treatment device of the present invention may further include a drug applicator 700 for applying cosmetics or drugs contained in a container to the skin.
  • a drug applicator 700 may be implemented in various forms.
  • the drug applicator 700 includes a ball 710 that is partially exposed at an end contacting the skin of the container body and is rotatably installed. It may be a roll-on type drug applicator or may be a drug applicator configured to apply the drug to the skin by an actuator or compressed gas.
  • This type of drug applicator 700 may include one or more outlets for evenly applying the cosmetic composition or drug to the skin, and such outlets may be disposed adjacent to the head of the handpiece or portable device.
  • the combined treatment apparatus of the present invention allows the drug to be delivered deeply under the stratum corneum by plasma treatment and electric field while applying the drug, so that the treatment or skin improvement effect can be ensured faster and more reliably.
  • the control unit 500 operates a high-voltage high-frequency AC power supply from the power supply unit 600. Is supplied to the power electrode installed on the upper surface of the dielectric of the plasma generating unit 100. At this time, plasma is generated by the dielectric barrier discharge, and thus plasma having an even distribution is generated in the space between the dielectric and the skin.
  • the generated plasma contains various active species, and they stimulate and sterilize the target area while exercising along the electric field.
  • a mode selection unit for inputting which of the plasma generating unit 100 and the iontophoresis unit 200 is to be activated is formed, so these are selectively selected for the user's skin condition or the judgment of the procedure expert. By activating it, the drug for cosmetic or therapeutic purposes can penetrate deep into the skin.
  • the operating method of the complex surgical apparatus for promoting transdermal delivery of the present invention can be implemented as a computer-readable code on a computer-readable recording medium.
  • the computer-readable recording medium includes all types of recording devices that store data that can be read by a computer system. Examples of computer-readable recording media include ROM and RAM. There are CDROMs, magnetic tapes, floppy disks, optical data storage devices, and the like, and also include those implemented in the form of carrier waves such as transmission through the Internet.
  • the computer-readable recording medium is distributed over a computer system connected through a network, so that code that can be read by the processor can be stored and executed in a distributed manner.
  • FIG. 11 is a schematic cross-sectional view of a complex surgical device for promoting transdermal delivery according to another embodiment of the present invention
  • FIG. 12 is a schematic perspective view of a complex surgical apparatus for promoting transdermal delivery according to another embodiment of the present invention
  • 13 is a schematic cross-sectional configuration diagram of a complex procedure device for promoting transdermal delivery according to another embodiment of the present invention
  • FIG. 14 is a composite procedure device for promoting transdermal delivery according to another embodiment of the present invention Is a schematic block diagram of.
  • a complex treatment device for promoting transdermal delivery includes at least one electrode and a patterned dielectric part having a three-dimensional pattern disposed between the electrode and the skin, and Plasma generating unit 100 that generates plasma and sprays it on the skin, and ions having a plurality of electrodes spaced apart on the skin to allow microcurrent to flow through the skin by applying at least one of a voltage signal and a current signal to the skin It includes an electrophoresis unit 200, an ultrasound generator 300 for delivering ultrasonic energy to skin tissue, and an electroporation electrode unit 400 for emitting pulses that form microchannels in the skin.
  • the patterned dielectric part 140 is formed in a stripe shape as shown in Fig. 7(a) or a mesh type or a grid type as shown in Fig. 7(b), and in addition, a comb type, honeycomb type, or slit type In this way, the pattern-type dielectric part 140 has a microstructure similar to a plurality of protrusions formed by a three-dimensional pattern, and the protrusion 141 between the electrode and the skin. Since a discharge space for plasma discharge is sufficiently secured, there is no need to form a separate space maintaining unit or spacer. As shown in FIGS. 7(c)-(f), for example, the ridge 141 may have a hemispherical shape, a square pillar shape, a pyramid shape, and a polygonal column shape, but must be limited to this shape. It does not become.
  • the electrodes of the plasma generation unit 100, the iontophoresis unit 200, the ultrasonic generation unit 300, and the electroporation electrode unit 400 are disposed on the head in the complex treatment apparatus of the present invention.
  • the shape of the head is not particularly limited, and may have any shape such as a circle, a square, a rectangle, or an oval.
  • the complex treatment apparatus may further include an ozone filter 150 for removing residual ozone, and such an ozone filter is configured to be fitted and fixed to the inside of the plasma generating unit or outside the housing. It may be a filter coated with a chlorine atom or a photocatalyst to reduce to.
  • the complex treatment device of another embodiment of the present invention further includes a drug applicator 700 for applying cosmetics or drugs contained in the container to the skin, and the drug applicator is formed at the side end, as shown in FIG. Alternatively, as shown in FIG. 13, it may be formed between the plasma generation unit, the electroporation electrode unit, the iontophoresis unit, and the ultrasonic generation unit.
  • a drug applicator 700 is a roll-on type drug applicator including a ball that is partially exposed and rotatably installed at an end contacting the skin of the container body, or by a pump, an actuator or compressed gas. It may be a drug applicator configured to apply the drug onto the skin.
  • the plasma generation unit 100, the iontophoresis unit 200, the ultrasound generation unit 300, and the electroporation electrode unit 400 are disposed adjacent in a direction parallel to the skin surface, or alternatively, the iontophoresis unit ,
  • the ultrasonic generator, and the electroporation electrode part are arranged adjacent to each other in a direction parallel to the skin surface, or as shown in FIG. 10, the plasma generating part 100 is an iontophoresis part 200, an ultrasonic generator ( 300) and the electroporation electrode unit 400 may be mounted in a detachable cap manner.
  • the complex treatment apparatus of another embodiment of the present invention further includes an interference blocking unit (not shown) for preventing interference caused by electromagnetic waves between the plasma generating unit, the ultrasonic generating unit, the iontophoresis unit, and the electroporation electrode unit.
  • an interference blocking unit (not shown) for preventing interference caused by electromagnetic waves between the plasma generating unit, the ultrasonic generating unit, the iontophoresis unit, and the electroporation electrode unit.
  • 16 is a graph showing a result of a transdermal absorption test of an active part of the skin using a complex surgical device for promoting transdermal delivery according to an embodiment of the present invention.
  • This test is a test group, and the time after applying'NA solution' containing about 2% of niacinamide, an index component, to human skin irradiated with plasma and ultrasound using the complex procedure device for promoting transdermal delivery of this example. After confirming the transdermal penetration pattern and skin absorption of the index component over time, applying the aforementioned'NA solution' to the human skin that has not radiated plasma and ultrasound as a control, and then determining the transdermal penetration and skin absorption of the indicator component over time. As a test to confirm, the graph of FIG. 16 compares and shows the degree to which the index components of the test group and the control group are absorbed into human skin.
  • This test uses the in vitro skin absorption test method (Guideline for the in vivo skin absorption test, 2010) and test methods such as MHLee (MH Lee et al., 2016) for the skin absorption of the index component. The effect of the sample was confirmed.
  • MHLee MH Lee et al., 2016
  • the diffusion coefficient for the test substance was relatively high in the range of 0.25 to 12 hours of sample administration compared to the skin of the control group, and the skin penetration rate was about 4.66 times higher than that of the control group.

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Abstract

L'invention concerne un appareil de procédure complexe pour favoriser l'administration transdermique. Selon un aspect de la présente invention, un appareil de procédure complexe pour favoriser l'administration transdermique est décrit, comprenant : une première pièce à main dans laquelle est disposée une unité de génération de plasma pour générer un plasma par haute tension afin de pulvériser le plasma sur la peau ; une seconde pièce à main dans laquelle est disposée une unité de génération d'ultrasons pour générer des ondes ultrasonores afin de transmettre une énergie ultrasonore au tissu cutané ; et une partie de maintien qui fournit de l'énergie à l'unité de génération de plasma et à l'unité de génération d'ultrasons et dans laquelle les pièces à main sont maintenues.
PCT/KR2019/003859 2019-04-01 2019-04-02 Appareil de procédure complexe pour favoriser l'administration transdermique WO2020204224A1 (fr)

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