WO2018072807A1 - Dispositif et procédé de détermination d'implications pathologiques - Google Patents

Dispositif et procédé de détermination d'implications pathologiques Download PDF

Info

Publication number
WO2018072807A1
WO2018072807A1 PCT/EP2016/072949 EP2016072949W WO2018072807A1 WO 2018072807 A1 WO2018072807 A1 WO 2018072807A1 EP 2016072949 W EP2016072949 W EP 2016072949W WO 2018072807 A1 WO2018072807 A1 WO 2018072807A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
endoscope
infrared
segment
reflected
Prior art date
Application number
PCT/EP2016/072949
Other languages
German (de)
English (en)
Inventor
Thomas Engel
Maximilian Fleischer
Alexander Michael Gigler
Remigiusz Pastusiak
Tobias Paust
Elfriede Simon
Evamaria STÜTZ
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Priority to PCT/EP2016/072949 priority Critical patent/WO2018072807A1/fr
Publication of WO2018072807A1 publication Critical patent/WO2018072807A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00193—Optical arrangements adapted for stereoscopic vision
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00194—Optical arrangements adapted for three-dimensional imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0646—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements with illumination filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0669—Endoscope light sources at proximal end of an endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0684—Endoscope light sources using light emitting diodes [LED]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2453—Optical details of the proximal end
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/26—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/208—Filters for use with infrared or ultraviolet radiation, e.g. for separating visible light from infrared and/or ultraviolet radiation

Definitions

  • This invention relates to an apparatus for detecting pathological implications according to the preamble of claim 1 and a method for detecting pathological implications according to the preamble of claim 25.
  • the object underlying the invention is as ⁇ rin to provide a comparison with the prior art improved solution.
  • This object is achieved by the device according to the preamble ⁇ concept of claim 1 by its features, and solved by the method according to the preamble of claim 25 by the features.
  • the inventive apparatus for detecting pathological implications ⁇ shear has a three-dimensional
  • the device is such as knowgebil ⁇ det, preferably that the endoscope for two- and / or three-dimensional imaging is designed.
  • the device of the invention is further developed such that for the endoscope and the spectrometer ei ⁇ ne is arranged at least a first common light source for emitting light to a surface to be examined and operatively connected with them. This can be done
  • the device according to the invention is further developed in such a way that the functional compound is such out ⁇ staltet that a first light channel guides the light of the public ⁇ seed light source from the proximal end of the endoscope to dis ⁇ talen end of the endoscope.
  • the first common light source is designed such that it emits light in the wavelength range of visible and infrared light.
  • the first common light source is designed such that it emits light in the wavelength range of visible light
  • the second common light source is designed such that it emits light in the wavelength range inf ⁇ rarotem light
  • the first and second light source are arranged spatially separated from each other and a semi-transparent and / or wavelength-selective mirror is arranged such that the infrared light passes through the mirror and the visible light from the mirror into the beam path of the infrared light is directed or arranged so that visible light passes through the mirror and the infrared light is directed by the mirror in the beam path of the infrared light.
  • freedom ⁇ degrees are achieved in the arrangement of the light sources, since their output light through the mirror by selecting the dimension and / or spectral distribution of the reflectivity and / or the appropriate angle can be combined properly.
  • the device according to the invention is further developed in such a way that the light channel is designed to guide infrared light components and visible light components. This helps to reduce the size of the endoscope and thus improve its capabilities and handling.
  • the endoscope and the spectrometer are configured and radio ⁇ tional connected, that a second light channel reflected directs portions of the light of the common light source from the distal end of the endoscope to the proximal end of the endoscope.
  • the inventive device can in such a further developed who, ⁇ that endoscope and the spectrometer are configured and operably connected that reflected light components at the proximal end of the endoscope are fed through a filter the spectroscope, wherein the Filter is designed such that it allows infrared light to pass.
  • the device according to the invention is further developed such that the first and / or second light channel is designed such that it is formed of at least one glass fiber reinforced ⁇ ser.
  • the endoscope and the spectrometer are functionally connected to a manipulation device which is designed such that infrared components, in particular near-infrared components, of a light incident on the surface, thus being reflected by a surface to be examined, also protects against adulteration portion of the spectrum of the reflected light is ma ⁇ nipuliert remaining, in particular visible, that the reflected infrared components and the reflected visible portions spaced apart to- be returned so that they, in particular at the output of the
  • the second light channel configured and functionally connected to Endo ⁇ skop and spectrometer that it leads the infrared portion of the spectrum of the reflected light, it is ensured that the evaluation by the spectrometer by distortions by the visible light provides less accurate results.
  • a further advantageous development of the device according to the invention is given when the lens is segmented such that the manipulation device is designed as at least one lens arranged at the distal end of the endoscope, since the properties of a lens can be brought about by suitable grinding in an advantageous manner for the invention , This applies even more to the development of the device according to the invention in such a way that the lens is segmented.
  • advantageous ⁇ exemplary clearly distinct regions with or through the lens gege ⁇ ben.
  • a further advantageous development of the device according to the invention is given when the lens is such segmented, that an at least first lens segment focuses the reflektier ⁇ th proportion of the infrared light beams and a second lens segment focuses the invisible portion of the reflektier ⁇ th light, said segments configured are that preferably a diffuse portion of the reflection of the infrared component is attributed.
  • said segments configured are that preferably a diffuse portion of the reflection of the infrared component is attributed.
  • the lens is segmented such that a first segment and a second segment are arranged such that the first segment is bounded by a kon ⁇ centric with respect to the center of the lens extending first circle and the second segment is defined by a concentric with the center of the lens extending second circle and the first circle, wherein the radius of the second circle is larger than the radius of the f ⁇ th circle, and wherein the first segment configured and operably connected to the endoscope in that it is used to manipulate the visible portions of the reflected light, and the second segment is configured and operatively connected to the endoscope so as to be used to manipulate the infrared portions of the light.
  • a significantly simpler and more cost-effective with respect to the production alternative development is when the device according to the invention is developed such that a first segment and a second segment are arranged such that the first is bounded by a first circle and the second segment of a second circle is limited, wherein the first circle and the second circle are arranged to each other disjunctively and wherein the first segment of such ⁇ designed and functionally connected to the endoscope that it is used to manipulate the visible portions of the reflected light, and the second segment is such out ⁇ staltet and operatively connected to the endoscope, that it verwen- for manipulating the infrared portions of the light it becomes.
  • This development is also characterized by the fact that the proportion of the captured diffusely reflected portion of infrared light is greatest, and thus the IR
  • Spectrometry is the most comprehensive basis for determining the finding available.
  • the erfindungsge ⁇ Permitted device is further formed such that the OBJEK ⁇ tivlinse is segmented such that the first segment is delimited by a concentrically with respect to extending the center of the lens first circle and the second segments concentric with by second are the center point of the f ⁇ th circle and disjoint to the first circle, in particular uniformly distributed, placed, wherein the radius of the second circle is smaller than the radius of the first circle and where ⁇ configured and operably connected with the first segment with the endoscope is that it is used to manipulate the visible portions of the reflected light, and the second segments are configured and operatively connected to the endoscope so as to be used to manipulate the infrared portions of the light.
  • a balanced solution is given such that a mittle ⁇ res measure is captured of diffuse reflected infrared light, which also tet an average degree of signal intensity bending.
  • a second semitransparent mirror is positioned downstream of the endoscope in the emission direction of the light of the first and / or second light source, which is designed and arranged such that emitted light is reflected in the direction of the distal end and reflected light can happen to image the visible area.
  • This can effectively and easily Arte a waste ⁇ the branching of a portion of the reflected light realized.
  • the proximal end of a third semi-transparent and / or spectrally selective mirror in the beam path of the returned reflected oriented light is arranged, which is arranged functionally so connected to the endoscope and the spectrometer, and is that it reflects the reflected portion of the infrared light rays to the infrared spectrometer and lets the visible portion of the reflected light pass through to an imaging device.
  • the device according to the invention advantageously in front of the infrared spectrometer arranged and configured such that the visible portion of the re ⁇ inflected light is removed and arranged in front of the imaging device, a filter and is designed so that the infrared portion of the light is removed.
  • the light source is formed by a Hallogenate short arc lamp, in particular HBO, XBO, in particular fluorescence-converted and / or widened laser light source and / or at least one LED.
  • a wavelength range which is suitable for the invention can be covered completely, in particular flexibly, ver ⁇ likes the development of the device according to the invention in which the LED or an array of LEDs for emitting light of different, in particular adjustable, wavelength is configured.
  • the invention is intended to encompass all forms of segmental limitation that can be considered the effect explained or an effect equivalent to the effects explained and, for example, as imaging channels.
  • Such equivalent and also included further developments would be, for example, the use of different, in particular especially antireflex, coatings.
  • the inventive method for determination of pathological implications is characterized in that an infrared spectrometer is operated in a powered for three-dimensional imaging endoscope, wherein preferably for this purpose the method is further developed such that the En ⁇ doskop to the di- and / or Three-dimensional imaging is operated.
  • FIG. 1 is a prior art in a simplified representation of an endoscope and a schematic representation of the operation of an IR spectrometer
  • FIG. 2 is a representation of the basic structure of two embodiments of the integration according to the invention
  • FIGURE 3 is a simplified representation of detected Antei ⁇ len the remission after irradiation of a surface
  • FIG. 4 shows a schematic illustration of an embodiment according to the invention of the supply of the infrared light to the IR spectrometer
  • FIGURE 5 is a schematic representation of a SEN invention shown embodiment of the parallel implemented illumination of the surgical situs and the mapping of the reflected signals
  • Figure 6 is an illustration of the basic construction of another embodiment of the invention Integra ⁇ tion based on on-chip approach Tip
  • FIGURE 7 is a greatly simplified illustration of a ⁇ exporting approximately example of a segmented lens according to the invention
  • FIG. 8 shows an illustration of the basic construction of a second exemplary embodiment of the device according to the invention
  • FIGURE 1 the prior art is shown and ⁇ hand will be explained in which the object underlying the invention starting situation.
  • FIG. 1 shows an endoscope E, which likewise has its own second illumination (not shown).
  • Sce- rio shown according to the spectrometer (spectroscope) IRS is the light reflected by a light emitted from the first illumination infrared light from a sample SAMPLE Spekt ⁇ rum by the spectrometer IRS measured.
  • the wavelength-dependent attenuation of the light is observed and the data vector obtained for Schmé ⁇ chung (frequency) then usually classified by a statistical ⁇ 's method.
  • PLS partial least squares
  • Deep ANN for example Deep ANN.
  • Previous endoscopes using an illumination channel to white light for imaging to erzeu ⁇ gen, an illumination channel to generate the illumination pattern for 3D imaging via triangulation and a third channel to the optical image, either directly or to pick up medium chip-on tip technology.
  • the classic configuration for IR spectroscopy requires a light delivery of the light in the near (NIR) or mid (MIR) range, and a separate record of the Wegge ⁇ incident light spectrum.
  • FIG. 2 shows an embodiment of a erfindungsge- Gurss coupled endoscope, wherein the channel is now used in addition to the white light illumination ⁇ to apply the IR light. It uses a common fiber
  • GF_NIR_VIS which is permeable to both types of light.
  • a lamp can be used which includes both types of light as shown in the upper part or next to a first light source BL_VIS for visible light via a semitransparent or spectrally selective mirror, a second light source BL_NIR, as in the lower part of the figure represented are coupled into the given through the glass fiber illumination channel BK.
  • the possible reflection angles and effects are outlined in a greatly simplified manner.
  • the imaging lens focuses on an entire image section (large viewing angle / large field of view), the IR radiation is focused on a measuring point (small angle of view / small field of view or measuring field). This is ideally positioned in the co-te of the optical image and may be optionally ⁇ indicated to the user by an optical marking ge.
  • FIGURE 4 is a schematic representation of an embodiment of the inventive he ⁇ supply the infrared light to the IR spectrometer is shown.
  • a filter F_IR may be introduced in the beam path, which leaves only the IR light required field happen.
  • a meaningful structure can be found in FIG. 5.
  • a high-resolution fiber bundle GF is used.
  • the coupling of the mixed light from the light source is preferably effected by BLG In ⁇ terferenzfilter and interference levels, for example, via a semi-transparent and / or che for individual spectral ranges transparent mirror SP.
  • the lens according to the invention is more the aperture stop and no field stop.
  • the fiber could also serve as the entrance aperture of the IRS spectrometer. If one then follows the path here of wanting to have several measuring spots which measure in parallel, then several fiber ends could be arranged instead of the entrance slit on the spectrometer.
  • the same maximum optical aperture as an aperture is selected for the analysis of the infrared, in particular near infrared, portion by means of a field stop from the spectrometer ⁇ and IRS may then be fed.
  • the field stop is designed to be displaceable, in order to enable a scanning of the measuring field of the endoscope for the visible spectral range and also for the infrared portion of the radiation for the spectrally resolved measurement. It is particularly preferable when the shutter is au ⁇ tomatinstrument controlled for scanning is.
  • electromechanical actuating elements or else in the transmission electrically controllable filter elements can be used, as are common in display technology.
  • FIG. 7 shows a greatly simplified representation of an embodiment of an inventive segmented Lin ⁇ se SL.
  • an outer segmentation IR which is preferably to recirculate the diffusely reflected components of the infrared light (IR), as well as an inner segment VIS, wel ⁇ Ches can be applied for the return of the visible components (VIS).
  • the inner VIS segment produces large image angle, the optical image (opt. Abbil ⁇ formation), the outer small image angle the IR image in the spectrometer IRS. Both are then transported again via a fiber bundle GF, with a beam splitter SP. separated and the two sub-beams given if appropriate with appropriate filters F_VIS ... F_IR limited to the respective wavelength range.
  • the invention allows for the fact that in minimally invasive surgical procedures, which are carried out with the help of a medical endoscope, the malinvasiven noninvasive identifi ⁇ cation and differentiation of different tissues, which was otherwise very limited even in three-dimensional optical resolution possible, especially because in mini ⁇ surgery, the field of vision is limited and haptic methods for tissue differentiation are excluded.
  • the invention thus takes into account the fact that the non-invasive determination of healthy and diseased tissues, especially in tumors, therefore of very great importance. With this invention, this is described by the integration of an automated tissue recognition based on IR spectroscopy (which also works for typical glossy reflective surfaces) into an endoscope with 2D or 3D imaging.
  • the invention enriches the state of the art, in which there is no integration of the IR spectroscopy with an endoscope in the claimed form. It adds to the state of the art, on the one hand, advantages of the medical endoscopes currently used in minimally invasive surgery, such as classic stereo endoscopes, stereo polarization endoscopes and above all advantages of three-dimensional endoscopes with depth profile measurements based on triangulation methods with single-channel or stereoscopic endoscopes They are designed with pattern projectors, eg as random DOT or color coded triangulation, which allow a 3D depth measurement via the projected patterns, even on optically rather unstructured smooth surfaces and therefore rather uncooperative for triangulation.
  • pattern projectors eg as random DOT or color coded triangulation
  • Triangulation may occur between the images shown in training channels with different directions as well as between the projector and at least one imaging channel he ⁇ follow.
  • the invention enriches the state of the art by the advantages of IR spectroscopy, which has been investigated (in vivo) only in animal experiments with respect to tumor tissue and non-tumor tissue differentiation, but thanks to the integration according to the invention and the associated advantages such as dimensional reduction or accurate results helps to reduce trauma in tissue differentiation and thus contributes to the acceptance of the technology.
  • the spectrometer integrated according to the invention can provide the functions known from the prior art as well, for example, that the reflected IR spectrum is measured by means of a spectrometer from a sample, for example human tissue, and the wavelength-dependent weakening of the light is taken into account ,
  • the obtained data vector Schcie ⁇ chung (frequency) is classified then usually by means of a sta ⁇ tistical method (often used PLS, PLSDA, Support Vector Machine, ANN, Deep ANN).
  • Embodiments of the invention also consider that one needs a reference for the attenuation - a reference spectrum.
  • the invention is developed particularly suitable, if the manipulation unit also made a setting ⁇ light, in which the spectrometer directly and without the
  • Beam path over the sample can measure the spectrum emitted by the light source or sources and so a spectral reference can be determined.
  • the measured sample spectrum can be related to the reference spectrum, for example by normalization, and thus the relative attenuation can be determined, which can be used as a chemical In ⁇ formation of the sample.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Endoscopes (AREA)

Abstract

L'invention concerne un dispositif et un procédé de détermination d'implications pathologiques, comprenant la mise en oeuvre d'un spectromètre à infrarouge dans un endoscope utilisé pour l'acquisition d'images tridimensionnelles.
PCT/EP2016/072949 2016-09-27 2016-09-27 Dispositif et procédé de détermination d'implications pathologiques WO2018072807A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/072949 WO2018072807A1 (fr) 2016-09-27 2016-09-27 Dispositif et procédé de détermination d'implications pathologiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/072949 WO2018072807A1 (fr) 2016-09-27 2016-09-27 Dispositif et procédé de détermination d'implications pathologiques

Publications (1)

Publication Number Publication Date
WO2018072807A1 true WO2018072807A1 (fr) 2018-04-26

Family

ID=57123970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2016/072949 WO2018072807A1 (fr) 2016-09-27 2016-09-27 Dispositif et procédé de détermination d'implications pathologiques

Country Status (1)

Country Link
WO (1) WO2018072807A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050012843A1 (en) * 2003-05-21 2005-01-20 Koshi Kuwakino Visible and infrared light photographing lens system
US20080306337A1 (en) * 2007-06-11 2008-12-11 Board Of Regents, The University Of Texas System Characterization of a Near-Infrared Laparoscopic Hyperspectral Imaging System for Minimally Invasive Surgery
US20100234684A1 (en) * 2009-03-13 2010-09-16 Blume Jurgen Multifunctional endoscopic device and methods employing said device
US20110295062A1 (en) * 2008-12-11 2011-12-01 Fundacio Clinic Per A La Recerca Biomedica Fcrb Equipment for infrared vision of anatomical structures and signal processing methods thereof
US20130066215A1 (en) * 2006-10-19 2013-03-14 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
WO2013160780A1 (fr) * 2012-04-23 2013-10-31 I.R.Med Ltd. Technique d'imagerie et de spectroscopie infrarouge à ondes courtes pour la classification d'inflammations et la différentiation des tumeurs et des inflammations dans des tissus humains à l'intérieur du corps
WO2016003371A1 (fr) * 2014-07-02 2016-01-07 National University Of Singapore Système de spectroscopie raman, appareil et procédé d'analyse, caractérisation et/ou diagnostic d'un type ou d'une nature d'un échantillon ou d'un tissu tel qu'une croissance anormale

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050012843A1 (en) * 2003-05-21 2005-01-20 Koshi Kuwakino Visible and infrared light photographing lens system
US20130066215A1 (en) * 2006-10-19 2013-03-14 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US20080306337A1 (en) * 2007-06-11 2008-12-11 Board Of Regents, The University Of Texas System Characterization of a Near-Infrared Laparoscopic Hyperspectral Imaging System for Minimally Invasive Surgery
US20110295062A1 (en) * 2008-12-11 2011-12-01 Fundacio Clinic Per A La Recerca Biomedica Fcrb Equipment for infrared vision of anatomical structures and signal processing methods thereof
US20100234684A1 (en) * 2009-03-13 2010-09-16 Blume Jurgen Multifunctional endoscopic device and methods employing said device
WO2013160780A1 (fr) * 2012-04-23 2013-10-31 I.R.Med Ltd. Technique d'imagerie et de spectroscopie infrarouge à ondes courtes pour la classification d'inflammations et la différentiation des tumeurs et des inflammations dans des tissus humains à l'intérieur du corps
WO2016003371A1 (fr) * 2014-07-02 2016-01-07 National University Of Singapore Système de spectroscopie raman, appareil et procédé d'analyse, caractérisation et/ou diagnostic d'un type ou d'une nature d'un échantillon ou d'un tissu tel qu'une croissance anormale

Similar Documents

Publication Publication Date Title
DE10053447B4 (de) Endoskopsystem
DE10038875B4 (de) Endoskopsystem
DE60119930T2 (de) Verfahren und vorrichtung zur hochauflösenden kohärenten optischen abbildung
DE102009001086B4 (de) Handgehaltene dentale Kamera und Verfahren zur optischen 3D-Vermessung
EP2564763B1 (fr) Appareil d'analyse ophtalmologique et procédé
EP2482113B1 (fr) Microscope d'opération doté d'un système OCT
EP1918753B1 (fr) Microscope d'opération doté d'un système OCT
EP1918754B1 (fr) Microscope d'opération doté d'un système OCT
DE102017115105B4 (de) Optisches kohärenztomografie-system und -verfahren mit mehreren aperturen
DE102017000296B4 (de) Messsystem und Verfahren zur kombinierten Erfassung der Oberflächentopographie und hyperspektralen Bildgebung
EP3592210B1 (fr) Sonde optique et procédé pour le fonctionnement de la sonde optique
DE10043162A1 (de) Lichtleitfaserbündel und Endoskopeinrichtung
DE112015002260T5 (de) Endoskopsystem
WO1988003396A1 (fr) Dispositif pour la production d'images d'un objet et notamment pour l'observation des parties arriere de l'oeil
DE102013009493A1 (de) Zahnmedizinische optische Messvorrichtung und zahnmedizinisches optisches Mess-/Diagnosewerkzeug
EP3484338A2 (fr) Dispositif endoscopique et procédé d'examen endoscopique
DE102017122160A1 (de) Endoskop
DE19721902A1 (de) Verfahren und Vorrichtung zur in-vivo-Detektion der Richtung von Langer-Linien in der Haut
DE102017109128B4 (de) Endoskop zur 3D-Vermessung von Objekten sowie zugehöriger Baukasten und Verwendung
EP3741290B1 (fr) Dispositif d'imagerie de lésions cutanées
EP3323340A1 (fr) Sonde endoscopique, système et procédé de tomographie par cohérence optique et d'endoscopie confocale
WO2018072807A1 (fr) Dispositif et procédé de détermination d'implications pathologiques
WO2018059657A1 (fr) Microscope chirurgical doté d'un spectromètre à infrarouge et procédé de détermination des incidences pathologiques faisant appel à celui-ci
DE60304343T2 (de) Vorrichtung für einen in vivo konfokalen optischen tomographieschnitt
EP1969995A1 (fr) Dispositif d'examen oculaire

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16779023

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16779023

Country of ref document: EP

Kind code of ref document: A1