WO2018066948A3 - 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법 - Google Patents

다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법 Download PDF

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Publication number
WO2018066948A3
WO2018066948A3 PCT/KR2017/011027 KR2017011027W WO2018066948A3 WO 2018066948 A3 WO2018066948 A3 WO 2018066948A3 KR 2017011027 W KR2017011027 W KR 2017011027W WO 2018066948 A3 WO2018066948 A3 WO 2018066948A3
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WO
WIPO (PCT)
Prior art keywords
recombinant antigen
antigen protein
recombinant
expression vector
mouth disease
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PCT/KR2017/011027
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English (en)
French (fr)
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WO2018066948A2 (ko
WO2018066948A9 (ko
Inventor
최윤재
강상기
조종수
이호빈
Original Assignee
서울대학교산학협력단
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Priority claimed from KR1020170127219A external-priority patent/KR101991577B1/ko
Publication of WO2018066948A2 publication Critical patent/WO2018066948A2/ko
Publication of WO2018066948A3 publication Critical patent/WO2018066948A3/ko
Publication of WO2018066948A9 publication Critical patent/WO2018066948A9/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 구제역 아단위 백신 개발을 위하여 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 생산 방법에 관한 것으로, 본 발명에 따른 재조합 발현벡터는 미생물 배양을 통하여 재조합 항원 단백질을 저렴하고 안전하게 대량 생산할 수 있으며, 손쉽게 정제가 가능한 장점이 있으며, 상기 재조합 발현벡터에서 생산된 재조합 항원 단백질은 멀티-에피토프로 구성되어 다양한 구제역 변이체에 대한 면역반응을 향상시킬 수 있음이 확인됨에 따라, 상기 재조합 발현벡터는 효과적인 구제역 아단위 백신으로 사용될 수 있는 재조합 항원 단백질을 제공하기 위한 도구로 유용하게 사용될 수 있다.
PCT/KR2017/011027 2016-10-05 2017-09-29 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법 WO2018066948A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160128433 2016-10-05
KR10-2016-0128433 2016-10-05
KR1020170127219A KR101991577B1 (ko) 2016-10-05 2017-09-29 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법
KR10-2017-0127219 2017-09-29

Publications (3)

Publication Number Publication Date
WO2018066948A2 WO2018066948A2 (ko) 2018-04-12
WO2018066948A3 true WO2018066948A3 (ko) 2018-10-04
WO2018066948A9 WO2018066948A9 (ko) 2018-11-01

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PCT/KR2017/011027 WO2018066948A2 (ko) 2016-10-05 2017-09-29 다수의 에피토프로 구성된 재조합 항원 단백질 및 이의 제조방법

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WO (1) WO2018066948A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111208302B (zh) * 2020-01-14 2021-04-13 中国农业科学院兰州兽医研究所 利用多表位串联蛋白检测猪口蹄疫o型抗体的化学发光检测试剂盒
CN115340609B (zh) * 2021-05-12 2023-06-13 中国农业科学院兰州兽医研究所 一种口蹄疫病毒多抗原表位融合蛋白、蛋白笼纳米颗粒及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066954A1 (en) * 1998-06-20 1999-12-29 United Biomedical Inc. Synthetic peptide vaccines for foot-and-mouth disease
KR20150084993A (ko) * 2012-11-16 2015-07-22 유나이티드 바이오메디칼 인크. 구제역 (fmd)에 대한 합성 펩티드-기재 응급 백신

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066954A1 (en) * 1998-06-20 1999-12-29 United Biomedical Inc. Synthetic peptide vaccines for foot-and-mouth disease
KR20150084993A (ko) * 2012-11-16 2015-07-22 유나이티드 바이오메디칼 인크. 구제역 (fmd)에 대한 합성 펩티드-기재 응급 백신

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLANCO, E. ET AL.: "Full Protection of Swine against Foot-and-mouth Disease by a Bivalent B- cell Epitope Dendrimer Peptide", ANTIVIRAL RESEARCH, vol. 129, 5 March 2016 (2016-03-05), pages 74 - 80, XP029487174 *
CUBILLOS, C. ET AL.: "Enhanced Mucosal Immunoglobulin A Response and Solid Protection against Foot-and-mouth Disease Virus Challenge Induced by a Novel Dendrimeric Peptide", JOURNAL OF VIROLOGY, vol. 82, no. 14, July 2008 (2008-07-01), pages 7223 - 7230, XP002677353 *
KIM, S.-H. ET AL.: "Targeted Delivery of VP1 Antigen of Foot-and-mouth Disease Virus to M Cells Enhances the Antigen-specific Systemic and Mucosal Immune Response", IMMUNE NETWORK, vol. 13, no. 4, August 2013 (2013-08-01), pages 157 - 162, XP055558012 *
LEE, H.-B. ET AL.: "Artificially Designed Recombinant Protein Composed of Multiple Epitopes of Foot-and-mouth Disease Virus as a Vaccine Candidate", MICROBIAL CELL FACTORIES, vol. 16, 22 February 2017 (2017-02-22), pages 1 - 10, XP055558018 *

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Publication number Publication date
WO2018066948A2 (ko) 2018-04-12
WO2018066948A9 (ko) 2018-11-01

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