WO2018055150A1 - Dispositif de génération d'un champ magnétique - Google Patents

Dispositif de génération d'un champ magnétique Download PDF

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Publication number
WO2018055150A1
WO2018055150A1 PCT/EP2017/074179 EP2017074179W WO2018055150A1 WO 2018055150 A1 WO2018055150 A1 WO 2018055150A1 EP 2017074179 W EP2017074179 W EP 2017074179W WO 2018055150 A1 WO2018055150 A1 WO 2018055150A1
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WO
WIPO (PCT)
Prior art keywords
coils
coil
magnetic field
same
electromotive source
Prior art date
Application number
PCT/EP2017/074179
Other languages
English (en)
Inventor
Nicolás CASSINELLI
Original Assignee
Nanoscale Biomagnetics S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoscale Biomagnetics S.L. filed Critical Nanoscale Biomagnetics S.L.
Publication of WO2018055150A1 publication Critical patent/WO2018055150A1/fr

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/02—Induction heating
    • H05B6/36—Coil arrangements
    • H05B6/44—Coil arrangements having more than one coil or coil segment
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/02—Induction heating
    • H05B6/36—Coil arrangements

Definitions

  • the present invention is a device for generating a magnetic field particularly suitable for use in methods of heating by means of magnetic field coupling (HMC) in general, and magnetic hyperthermia coupling in particular.
  • HMC magnetic field coupling
  • the invention is characterized by the combination of at least four coils and an electromotive source such that a region on which an oscillating magnetic field is generated is established such that, outside the device, the magnetic field is minimal without requiring magnetic field shielding elements.
  • Magnetic hyperthermia is a therapeutic technique that uses heat generated by magnetic nanomaterials when being exposed to an alternating magnetic field (AMF) to reduce the size of certain tumors, improve their response to radiotherapy, and even completely eliminate the tumor.
  • AMF alternating magnetic field
  • Alternating magnetic fields usually operate at frequencies less than 1 MHz and intensities in the order of 10 4 Amperes/meter (hundreds of Oersted) . Focusing this type of electromagnetic radiation on the region under study is of interest mainly due to factors that include energy efficiency, safety in use and compatibility with regulations in force.
  • Solenoid inductor is the simplest and most widely used field radiator. By means of this geometry, the highest energy density available is located in the cylindrical space surrounded by turns. Given that the magnetic flux lines are closed, the scattered flux in the rest of the space decreases with distance and is particularly intense in the axial direction.
  • the present invention solves the problem with a particular combination of coils without requiring shields.
  • the present invention relates to a device for generating a magnetic field configured such that it does not require a shield for shielding the generated magnetic flux.
  • Said device comprises :
  • a first set of two coils, a first coil and a second coil essentially the same, coaxial and spaced from one another by a pre-established distance d ;
  • a second set of two coils, a third coil and a fourth coil essentially the same, coaxial and spaced from one another by a second pre-established distance d 2 , with d 2 > d 1 ,
  • At least one alternating electromotive source for the excitation of the four coils where each coil is powered at the same frequency and phase.
  • the first set of coils formed by the first coil and the second coil is intended for generating the magnetic field which will have great contribution in the region of interest.
  • This region of interest is located at the intermediate point between both coils and according to the axial position. In this region, the magnetic field is very uniform, as if it were formed by a single very large solenoid, and allows accessing the region of interest from directions perpendicular to the axial direction. The samples that are subjected to the alternating magnetic field will be located in this region of interest.
  • the second set of coils is constructed with a larger distance between the coils such that the first set of coils is housed in the separation existing between both.
  • This second set of coils has the function of attenuating the resulting magnetic flux in the region outside the device by establishing a magnetic field having similar magnitude and direction virtually opposite the direction generated by the first set at each point of the space outside the device. To demonstrate this function, the four coils furthermore demonstrate that:
  • the first set of coils and the second set of coils are coaxial ;
  • the first set of two coils is located between the third coil and the fourth coil of the second set;
  • the geometric midpoint of the first set coincides with the geometric midpoint of the second set;
  • the at least one electromotive source as well as the first coil and the second coil of the first set are adapted for generating a magnetic field with the same direction ;
  • the at least one electromotive source as well as the third coil and the fourth coil of the second set are adapted for generating a magnetic field with the same direction but with direction opposite the direction of the coils of the first group .
  • the direction defined by the geometric axis of the coil is identified as axial direction.
  • the coils can have a flat, square or rectangular configuration, although the preferred configuration is that of a solenoid having a circular section.
  • the direction of the magnetic flux created by the coil depends on the orientation of the turns of the coil and on the polarization of the electromotive source. In other words, if the winding direction is changed, going around the coil 180°, the direction of the magnetic field also changes. If the winding direction is maintained but the polarization of the electromotive source is changed, the magnetic field also changes direction. Finally, if the winding direction is changed, going around the coil 180°, and the polarization of the electromotive source is changed then the direction of the magnetic field generated does not change.
  • the electromotive source is an alternating electromotive source, so all the coils must be powered at the same frequency and phase.
  • a coil powered by an alternating electromotive source generates an also alternating magnetic field, when it is established that a coil generates a magnetic field in a specific direction and another coil in an opposite direction, it shall be interpreted that said condition applies when both coils are observed at the same time instant.
  • a simple way to power the two frequency- and phase- synchronized coils is to establish a serial electrical connection of both coils by connecting a terminal of one coil with another terminal of the other coil and, to power the free terminals of both coils by means of the electromotive source.
  • Figure 1 shows a schematic depiction of an example of the invention in which an electromotive source is used for the excitation of the coils.
  • Figure 2 shows a schematic depiction of another embodiment of the invention in which two electromotive sources are used separately powering the pairs of coils of the first group and second group.
  • FIG. 3 shows a schematic depiction of another embodiment of the invention in which two electromotive sources are used separately powering the pairs of adjacent coils.
  • the present invention relates to a device for generating a magnetic field without requiring magnetic shielding.
  • FIG. 1 shows a schematic depiction of a first embodiment.
  • a first set is formed by two coils, a first coil (CI) and a second coil (C2) .
  • both coils (CI, C2 ) are the same because they have the same number of turns and the same configuration, and are spaced from one another by a pre-established distance identified as d .
  • the two coils (CI, C2 ) are coaxial and define a space between them which allows establishing a working region in which the magnetic field is highly uniform.
  • This first set of two coils (CI, C2 ) is located centered between a second set of two same, coaxial coils, a third coil (C3) a fourth coil (C4), sufficiently spaced from one another so as to allow housing the first set of coils (CI, C2) .
  • the distance between the two coils of the second group (C3, C4) is the pre-established distance identified as d 2 where d 2 > d is demonstrated.
  • the four coils (CI, C2 , C3, C4) are powered by an alternating electromotive source (E) which, in an operative mode, powers them with the same frequency and phase.
  • Figure 1 schematically shows a single line electrically communicating the electromotive source (E) and each coil (CI, C2 , C3, C4) graphically representing several alternative ways of supplying power :
  • the line represents the two conductors which originate from the electromotive source (E) and directly power the two terminals of the coil or
  • the coils can be connected to one another in series in twos and both pairs of coils can be powered in parallel.
  • the coils of the second group (C3, C4) are adapted, along with the electromotive source (E) powering them, for generating a magnetic field oriented in the direction opposite the magnetic field generated by the coils of the first group (CI, C2) .
  • the magnetic field generated by the coils of the first group therefore serves, in the central part thereof, for establishing the field in the working region; and the field that comes out containing the flux lines are counteracted by the flux created by the coils (C3, C4) of the second group, preventing the need to shield the entire device.
  • Each of the coils can be powered, for example, by an independent alternating electromotive source (E) , provided that all the electromotive sources are frequency- and phase- synchronized.
  • E independent alternating electromotive source
  • first electromotive source (E) powering the coils (CI, C2 ) of the first group of coils
  • second electromotive source (E) powering the coils (C3, C4) of the second group of coils. Therefore, the first electromotive source (E) is intended for generating the magnetic field which extends through the working region and the second electromotive source (E) is intended for generating the magnetic field which serves for shielding the device and efficiently attenuating the resulting magnetic field in an area away from the device.
  • FIG 3 shows a preferred embodiment which also uses two separate alternating electromotive sources, a first electromotive source (E) powering the first coil (CI) and the third (C3) coil and a second electromotive source (E) powering the second coil (C2) and the fourth (C4) coil.
  • Each electromotive source (E) therefore powers a pair of adjacent coils, which generates on one hand the field for the working region and also the coil externally shielding the magnetic field.
  • This configuration is preferred because it has been observed surprisingly in experiments that the overall consumption resulting from the sum of the consumptions of the first electromotive source (E) and of the second electromotive source (E) are considerably lower.
  • the three embodiments show a support (S) intended for keeping an object (0) in place in the working region, so that said object is subjected to the uniform alternating magnetic field in the operative mode.
  • This support (S) is configured such that the object (0) is located centered between the first coil (CI) and the second coil (C2), according to the axial axis of symmetry of the coils (CI, C2) .
  • connection is carried out between the adjacent coils of the first and second group of coils, for example, either between the first coil (CI) and the third coil (C3), or between the second coil (C2) and the fourth coil (C4), the connection must be in series but with the polarization of one of them being reverse so that magnetic fields with opposite directions are generated with the same electromotive source (E) .
  • the diameter D of all the coils is the same, the support is located according to the axial direction in a position located in an interval 0.5 ⁇ d /D ⁇ 1.5 and additionally the supporting means (S) are adapted so that the physical object (0) to be subjected to the magnetic field is located according to the axial direction in a position centered in the geometric center of the first set of coils.
  • This position centered according to the axial direction is interpreted as the position being able to be at any point of the transverse plane (P) transverse to the axial direction provided that the transverse plane (P) is centered in the geometric center of the first set of coils.
  • a preferred example is when the centered position coincides with the axis of the coils (CI, C2); i.e., in the intersection of the transverse plane (P) and the axis of the coils (CI, C2) .
  • the coils (CI, C2 , C3, C4) are configured in the form of a solenoid having a length I .
  • the length of the solenoid I satisfies the condition I ⁇ A/2 .
  • one or more coils (CI, C2 , C3, C4) is formed from conductive tube to allow the passage of a coolant which allows discharging the heat generated in the coil.

Landscapes

  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Shielding Devices Or Components To Electric Or Magnetic Fields (AREA)

Abstract

La présente invention est caractérisée par la combinaison d'au moins quatre bobines et d'une source électromotrice de telle sorte qu'une région sur laquelle un champ magnétique oscillant est généré est établie de manière que, à l'extérieur du dispositif, le champ magnétique est minimal sans nécessiter d'éléments de protection contre le champ magnétique.
PCT/EP2017/074179 2016-09-26 2017-09-25 Dispositif de génération d'un champ magnétique WO2018055150A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16382446.9 2016-09-26
EP16382446 2016-09-26

Publications (1)

Publication Number Publication Date
WO2018055150A1 true WO2018055150A1 (fr) 2018-03-29

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010125510A1 (fr) 2009-04-30 2010-11-04 Koninklijke Philips Electronics N.V. Agencement et procédé pour influencer et/ou détecter des particules magnétiques et pour une imagerie par résonance magnétique
WO2014088423A1 (fr) * 2012-12-04 2014-06-12 Sinvent As Appareil et procédé pour chauffage par induction de matériaux magnétiques
US20160060725A1 (en) * 2013-08-27 2016-03-03 Metalsa S.A. De C.V. Induction Heat-Treating Apparatus and Process
WO2016039644A2 (fr) * 2014-09-11 2016-03-17 Auckland Uniservices Limited Structures de couplage de flux magnétique à annulation de flux contrôlée
WO2016102669A1 (fr) * 2014-12-23 2016-06-30 Bond B.V. Tête d'impression par dépôt

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010125510A1 (fr) 2009-04-30 2010-11-04 Koninklijke Philips Electronics N.V. Agencement et procédé pour influencer et/ou détecter des particules magnétiques et pour une imagerie par résonance magnétique
WO2014088423A1 (fr) * 2012-12-04 2014-06-12 Sinvent As Appareil et procédé pour chauffage par induction de matériaux magnétiques
US20160060725A1 (en) * 2013-08-27 2016-03-03 Metalsa S.A. De C.V. Induction Heat-Treating Apparatus and Process
WO2016039644A2 (fr) * 2014-09-11 2016-03-17 Auckland Uniservices Limited Structures de couplage de flux magnétique à annulation de flux contrôlée
WO2016102669A1 (fr) * 2014-12-23 2016-06-30 Bond B.V. Tête d'impression par dépôt

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