WO2018039842A1 - Imidacloprid preparation process - Google Patents

Imidacloprid preparation process Download PDF

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Publication number
WO2018039842A1
WO2018039842A1 PCT/CN2016/097090 CN2016097090W WO2018039842A1 WO 2018039842 A1 WO2018039842 A1 WO 2018039842A1 CN 2016097090 W CN2016097090 W CN 2016097090W WO 2018039842 A1 WO2018039842 A1 WO 2018039842A1
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Prior art keywords
hour
finished product
same
glyphosate
stirring
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PCT/CN2016/097090
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French (fr)
Chinese (zh)
Inventor
沈建美
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沈建美
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Priority to PCT/CN2016/097090 priority Critical patent/WO2018039842A1/en
Publication of WO2018039842A1 publication Critical patent/WO2018039842A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals

Definitions

  • the invention relates to the field of preparation of pesticides, in particular to a preparation process of imidacloprid.
  • Imidacloprid is a systemic herbicide that has excellent control effect on weeds, especially perennial weeds, but its efficacy is slow, especially in the winter and spring low seasons. It takes 15-20 days for weeds to begin. Death is not good for controlling weeds quickly and effectively, and it is not convenient for farmers to flexibly control the time of application.
  • Paraquat is a contact-type quick-acting herbicide. The herbicide speed is very fast. The weeds are killed in 2-4 days after the general medicine, but there is no conductivity in the weeds, which often causes the grass to be incomplete. Especially for perennial weeds.
  • the technical problem to be solved by the present invention is to provide a process for preparing imidacloprid.
  • the technical scheme of the present invention is: a preparation process of imidacloprid, and the innovation is as follows: the preparation steps are as follows:
  • the invention discloses a preparation process of imidacloprid, and the preparation steps thereof are as follows:
  • glyphosate and paraquat into a paste-like herbicide ensures the efficacy of the drug, and because it is a creamy agent, it is inconvenient to swallow, and it can also prevent impulsive use and reduce the probability of poisoning death.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Provided is an imidacloprid preparation process, comprising the following preparation steps: heating: firstly adding water into a reaction kettle, starting agitation at a low speed, and controlling the temperature to be 70ºC-80ºC; dosing: sequentially adding an alkyl glycoside, a polyisocyanate curing agent, a sodium carboxymethyl cellulose disintegrating agent and a specially modified polyether, and stirring same for half an hour; adding active ingredients: adding a paraquat mother liquor and glyphosate, followed by sequentially adding safety-assistant components such as an emetic, a warning color, an odorant and a bitterant, then adding water, and continuously maintaining the temperature and stirring for an hour at a low speed to obtain the finished product; and sub-packaging: packaging the finished product by loading 200 kg of same into every wide-mouthed galvanized iron bucket or loading 50 kg of same into each plastic paper tube. The herbicide in a paste-like state prepared by mixing glyphosate with paraquat guarantees the efficacy of same, and meanwhile can prevent impulsive administration because of the inconvenience of swallowing a paste-like medicament, thereby decreasing the possibility of death caused by poisoning.

Description

一种吡虫啉制备工艺 Preparation process of imidacloprid 一种吡虫啉制备工艺Preparation process of imidacloprid
技术领域Technical field
本发明涉及一种农药制备领域，特别涉及一种吡虫啉的制备工艺。The invention relates to the field of preparation of pesticides, in particular to a preparation process of imidacloprid.
背景技术Background technique
吡虫啉是一种内吸传导型灭生性除草剂，对杂草特别是多年生杂草有优良的防效，但其药效缓慢，特别是冬春低温季节使用，要15-20天杂草才开始死亡，不利快速有效地控制杂草，也不便于农民灵活掌握施药时间。而百草枯是一种触杀型速效灭生性除草剂，杀草速度非常快，一般药后2-4天杂草即被杀死，但在杂草体内无传导性，往往造成杀草不彻底，特别是对多年生杂草效果差。目前已有两种除草剂的混合除草剂配方，但是百草枯制剂从口中进入体内超过一定量后，会对胃肠道、肝、肾、心、肺的损害作用均可危及生命，两者的混合除草剂的毒性很大，冲动性口服，极易造成死亡。Imidacloprid is a systemic herbicide that has excellent control effect on weeds, especially perennial weeds, but its efficacy is slow, especially in the winter and spring low seasons. It takes 15-20 days for weeds to begin. Death is not good for controlling weeds quickly and effectively, and it is not convenient for farmers to flexibly control the time of application. Paraquat is a contact-type quick-acting herbicide. The herbicide speed is very fast. The weeds are killed in 2-4 days after the general medicine, but there is no conductivity in the weeds, which often causes the grass to be incomplete. Especially for perennial weeds. At present, there are two herbicide mixed herbicide formulations, but after the paraquat preparation enters the body more than a certain amount from the mouth, the damage to the gastrointestinal tract, liver, kidney, heart and lung can be life-threatening. Mixed herbicides are very toxic, impulsive orally, and can easily cause death.
发明内容Summary of the invention
本发明要解决的技术问题是提供一种吡虫啉制备工艺。The technical problem to be solved by the present invention is to provide a process for preparing imidacloprid.
为解决上述技术问题，本实用新型的技术方案为：一种吡虫啉制备工艺，其创新点在于：其制备步骤如下：In order to solve the above technical problems, the technical scheme of the present invention is: a preparation process of imidacloprid, and the innovation is as follows: the preparation steps are as follows:
（1）加热：先向反应釜中加入水，开动搅拌，低速，控制温度在70℃-80℃；(1) heating: first add water to the reaction kettle, start stirring, low speed, control temperature is 70 ° C -80 ° C;
（2）配料：依次加入烷基糖苷、多异氰酸酯固化剂、羧甲基纤维素钠崩解剂、特种改性聚醚，搅拌半小时；(2) Ingredients: sequentially add alkyl glycoside, polyisocyanate curing agent, sodium carboxymethyl cellulose disintegrant, special modified polyether, and stir for half an hour;
（3）加入有效成分：加入百草枯母液以及草甘膦，其中两者的有效成分比值为100:4，加完后依次加入催吐剂、警戒色、臭味剂和苦味剂安全辅助成份，然后加水，持续保温低速搅拌一小时后可得成品；(3) Adding active ingredients: adding paraquat mother liquor and glyphosate, wherein the effective ingredient ratio of the two is 100:4, and after adding, add emetic, warning color, odor and bittering agent safety auxiliary ingredients, and then add water. , continuous insulation and low-speed stirring for one hour to obtain the finished product;
（4）分装：成品用每只大口镀锌铁桶装载200kg或每只塑袋纸筒装载50kg包装。(4) Packing: The finished product is loaded with 200kg per large-mouth galvanized iron drum or 50kg per plastic bag paper drum.
本发明的优点在于：The advantages of the invention are:
（1）将草甘膦和百草枯混合制成膏体状的除草剂，在保证了药效的同时，因为是膏状药剂，吞食不方便，也可以防止冲动型服用，降低中毒死亡的概率。(1) Mixing glyphosate and paraquat into a paste-like herbicide, while ensuring the efficacy of the drug, because it is a paste-like agent, it is inconvenient to swallow, and it can also prevent impulsive use and reduce the probability of death from poisoning. .
（2）两者的其中百草枯的比例掌握很重要，比例过低，不能起到有效加快杀草速度的目的；比例过高，易造成杂草受药部分迅速枯死，从而影响杂草对草甘膦的吸收和传导，造成杀草不彻底；经试验百草枯和草甘膦有效成分的比值7:1为最优配比。(2) The proportion of paraquat in both is very important. The proportion is too low to effectively speed up the speed of killing grass. If the ratio is too high, it will easily cause the weeds to quickly die, thus affecting the weeds. The absorption and conduction of glyphosate resulted in incomplete grass killing; the ratio of the active ingredients of paraquat and glyphosate was 7:1 as the optimal ratio.
具体实施方式detailed description
本发明公开了一种吡虫啉制备工艺，其制备步骤如下：The invention discloses a preparation process of imidacloprid, and the preparation steps thereof are as follows:
（1）加热：先向反应釜中加入水，开动搅拌，低速，控制温度在70℃；(1) heating: first add water to the reaction kettle, start stirring, low speed, control temperature is 70 ° C;
（2）配料：依次加入烷基糖苷6%、多异氰酸酯固化剂、羧甲基纤维素钠崩解剂13%、特种改性聚醚（3%，搅拌半小时；(2) Ingredients: 6% alkyl glycoside, polyisocyanate curing agent, 13% sodium carboxymethyl cellulose disintegrant, and special modified polyether (3%, stirred for half an hour;
（3）加入有效成分：加入百草枯母液以及草甘膦，其中两者的有效成分比值为100:4，加完后依次加入催吐剂、警戒色、臭味剂和苦味剂安全辅助成份，然后加水，持续保温低速搅拌一小时后可得成品；(3) Adding active ingredients: adding paraquat mother liquor and glyphosate, wherein the effective ingredient ratio of the two is 100:4, and after adding, add emetic, warning color, odor and bittering agent safety auxiliary ingredients, and then add water. , continuous insulation and low-speed stirring for one hour to obtain the finished product;
（4）分装：成品用每只大口镀锌铁桶装载200kg或每只塑袋纸筒装载50kg包装。(4) Packing: The finished product is loaded with 200kg per large-mouth galvanized iron drum or 50kg per plastic bag paper drum.
将草甘膦和百草枯混合制成膏体状的除草剂，在保证了药效的同时，因为是膏状药剂，吞食不方便，也可以防止冲动型服用，降低中毒死亡的概率。The combination of glyphosate and paraquat into a paste-like herbicide ensures the efficacy of the drug, and because it is a creamy agent, it is inconvenient to swallow, and it can also prevent impulsive use and reduce the probability of poisoning death.
以上显示和描述了本发明的基本原理和主要特征。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。The basic principles and main features of the present invention have been shown and described above. It should be understood by those skilled in the art that the present invention is not limited by the foregoing embodiments, and that the present invention is only described in the foregoing description and the description of the present invention, without departing from the spirit and scope of the invention. Various changes and modifications are intended to be included within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and their equivalents.

Claims (1)

  1. 一种吡虫啉制备工艺，其特征在于：其制备步骤如下：A preparation process of imidacloprid, characterized in that the preparation steps are as follows:
    （1）加热：先向反应釜中加入水，开动搅拌，低速，控制温度在70℃-80℃；(1) heating: first add water to the reaction kettle, start stirring, low speed, control temperature is 70 ° C -80 ° C;
    （2）配料：依次加入烷基糖苷、多异氰酸酯固化剂、羧甲基纤维素钠崩解剂、特种改性聚醚，搅拌半小时；(2) Ingredients: sequentially add alkyl glycoside, polyisocyanate curing agent, sodium carboxymethyl cellulose disintegrant, special modified polyether, and stir for half an hour;
    （3）加入有效成分：加入百草枯母液以及草甘膦，其中两者的有效成分比值为100:4，加完后依次加入催吐剂、警戒色、臭味剂和苦味剂安全辅助成份，然后加水，持续保温低速搅拌一小时后可得成品；(3) Adding active ingredients: adding paraquat mother liquor and glyphosate, wherein the effective ingredient ratio of the two is 100:4, and after adding, add emetic, warning color, odor and bittering agent safety auxiliary ingredients, and then add water. , continuous insulation and low-speed stirring for one hour to obtain the finished product;
    （4）分装：成品用每只大口镀锌铁桶装载200kg或每只塑袋纸筒装载50kg包装。(4) Packing: The finished product is loaded with 200kg per large-mouth galvanized iron drum or 50kg per plastic bag paper drum.
PCT/CN2016/097090 2016-08-29 2016-08-29 Imidacloprid preparation process WO2018039842A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/097090 WO2018039842A1 (en) 2016-08-29 2016-08-29 Imidacloprid preparation process

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1232614A (en) * 1999-01-14 1999-10-27 龚庆维 Composition containing glyphosate and paraguat
CN102657153A (en) * 2011-12-30 2012-09-12 广西田园生化股份有限公司 Paraquat paste agent and preparation method thereof
CN103202297A (en) * 2012-12-18 2013-07-17 江苏凯元科技有限公司 Processing method of high-efficient paraquat paste

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1232614A (en) * 1999-01-14 1999-10-27 龚庆维 Composition containing glyphosate and paraguat
CN102657153A (en) * 2011-12-30 2012-09-12 广西田园生化股份有限公司 Paraquat paste agent and preparation method thereof
CN103202297A (en) * 2012-12-18 2013-07-17 江苏凯元科技有限公司 Processing method of high-efficient paraquat paste

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