WO2018036289A1 - 一种农药组合物 - Google Patents
一种农药组合物 Download PDFInfo
- Publication number
- WO2018036289A1 WO2018036289A1 PCT/CN2017/092405 CN2017092405W WO2018036289A1 WO 2018036289 A1 WO2018036289 A1 WO 2018036289A1 CN 2017092405 W CN2017092405 W CN 2017092405W WO 2018036289 A1 WO2018036289 A1 WO 2018036289A1
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- WO
- WIPO (PCT)
- Prior art keywords
- active component
- composition
- tebuconazole
- thiabendazole
- prothioconazole
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
Definitions
- the invention is mainly applied to a pesticide composition in the field of agricultural plant protection, comprising one of the active ingredients thifenone and prothioconazole or tebuconazole.
- Pyraclostrobin is a new type of high-efficiency plant growth regulator. When thidiazepine is absorbed by plants, it can promote the separation of the petioles and stems, thus promoting the shedding of mature leaves. At higher concentrations, it can stimulate the formation of ethylene. Promotes the activity of pectin and cellulase. Under low concentration conditions, it has an cytokines effect and can induce plant callus differentiation and bud emergence.
- the structure is as follows:
- prothioconazole The mechanism of action of prothioconazole is to inhibit the demethylation of the precursors of sterols in the fungus, lanosterol or 24-methylene dihydrogen, at the l4 position, ie demethylation inhibitors (DMIs). . It not only has good systemic activity, excellent protection, treatment and eradication activity, but also has a long-lasting effect. Through a large number of field efficacy tests, the results show that prothioconazole not only has good safety to crops, but also has good anti-disease and curative effect, and it has obvious yield increase. Compared with triazole-based fungicides, prothioconazole has more A broad spectrum of sterilization live.
- Prothioconazole is mainly used to control many diseases such as wheat, barley, rape, peanut, rice and bean crops. It has good control effects on all wheat diseases, such as powdery mildew, sheath blight, blight, leaf spot, rust, sclerotinia, net blotch, and moiré in wheat and barley. It can also control soil-borne diseases such as Sclerotinia sclerotiorum and main foliar diseases such as gray mold, black spot, brown spot, black smut, sclerotinia and rust.
- the structure is as follows:
- Tebuconazole is a high-efficiency, broad-spectrum, systemic triazole bactericidal pesticide with three functions of protection, treatment and eradication. It has a wide spectrum of sterilization and a long-lasting effect. Qingdao Haohao High-tech Expert Group and New Zealand technical experts found that tebuconazole can inhibit the biosynthesis of fungal ergosterol, just like all triazole fungicides.
- Tebuconazole is used as a seed treatment agent and foliar spray in the world, and has a wide spectrum of sterilization, and has high activity and long duration. Tebuconazole is mainly used to control a variety of fungal diseases on crops such as wheat, rice, peanuts, vegetables, bananas, apples, pears and corn sorghum. It is registered and widely used in more than 60 crops in more than 50 countries around the world. . The product is used for controlling Sclerotinia sclerotiorum, not only has good control effect, but also has anti-barching effect, obvious effect of increasing yield, etc.
- tebuconazole is prepared by the steps of aldehyde-ketone condensation, catalytic hydrogenation, epoxidation reaction and addition reaction.
- the structural formula is:
- the object of the present invention is to provide a pesticide composition which can synergistically promote crop growth, prevent crop diseases, rapidly control the spread of crop diseases, increase crop yield, and achieve the purpose of disease resistance and yield increase. It has been found through experiments that after the combination of thiazole and prothioconazole or tebuconazole, it can regulate crop growth, better control crop diseases, improve the ability of crops to resist infection, and achieve the goal of disease resistance and yield increase.
- Another object of the present invention is to provide a preparation method comprising a combination of two active ingredients A and B agricultural compounds and an application for regulating and promoting crop growth in the agricultural field.
- the object of the invention can be achieved by the following measures:
- the present invention relates to a pesticidal composition, in particular to a synergistic plant growth regulator composition comprising two active components A and B, wherein active component A is thidiazuron, active group
- active component A is thidiazuron, active group
- the fraction B is selected from one of prothioconazole or tebuconazole, and the weight ratio between the two components is 1: (250 to 2) by weight of the active component A and the active component B.
- the active component B is a triazole pesticide.
- the weight ratio of the active component A to the active component B is 1: (200 to 5), and the weight ratio may be further preferably 1: (150 to 5) in order to make the effect more apparent. 1: (120: 5) or 1: (200 ⁇ 50). .
- the weight ratio of the active component thiabendazole to the active component prothioconazole is 1:150 to 10; the weight ratio of the active component thiabendazole to the active component tebuconazole is 1:180 to 10.
- the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratio.
- the invention finds through experiments that the composition is used for better control of crop diseases, and when the crop is infected by the pathogen, the compound is used to treat the crop, the disease transmission can be controlled better and faster, and the health effect of the crop can be promoted. To enhance the disease resistance of crops and improve the quality of crop products.
- the present invention provides the use of a composition comprising component A (thiabendazole) and component B (prothioconazole or tebuconazole) for regulating crop growth in the agricultural field, in particular for controlling crops such as wheat, rapeseed and peanuts.
- component A thiabendazole
- component B prothioconazole or tebuconazole
- composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with existing ones.
- pesticides such as fungicides, insecticides, herbicides, plant growth regulators
- fertilizers etc.
- composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and the pesticide adjuvant.
- the active ingredient in the composition has a mass content of from 5 to 85%, preferably from 5 to 60%.
- composition may specifically comprise an agrochemical auxiliary, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc., during the application process.
- an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
- an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
- Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
- the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
- the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
- the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant.
- Body Internal systemic action
- compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
- compositions of the present invention may be prepared in a pesticide acceptable dosage form such as a liquid, suspension, soluble liquid, oil suspension, microcapsule, microemulsion, suspension, and the like.
- a pesticide acceptable dosage form such as a liquid, suspension, soluble liquid, oil suspension, microcapsule, microemulsion, suspension, and the like.
- the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
- Microcapsule dosage forms suitable for the present invention include: microcapsule suspension, microcapsule suspension-suspension, microcapsule suspension-water emulsion, etc., characterized in that the inner wall of the capsule (ie, the capsule core) contains a mixture of active ingredients in a certain ratio. It is about to mix the two into microcapsules.
- the microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase.
- one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension.
- Agent-water emulsion Agent-water emulsion.
- composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
- the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
- ketones such as cyclohexanone
- highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
- vegetable or vegetable oils such as soybean oil.
- the above solid carriers are usually natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
- a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
- a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
- Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
- composition of the present invention can be applied in the agricultural field to regulate crop growth and control crop diseases.
- Plants or crops of the invention include, but are not limited to, wheat, canola or peanuts and the like.
- the two active ingredients in the composition of the present invention exhibit mutual promotion, the activity of the composition is higher than the expected activity of using a single compound, and the planting agent in the present invention can promote plant growth regulation, and the fungicide component can effectively kill Disease killer.
- the composition is used to treat the crop, and the bactericide in the composition can effectively prevent the spread and spread of the pathogen, and can better and better control the crop disease, and the plant growth regulator adjusts the crop in the composition. Growth, increase crop growth activity, and reduce the impact of crops on crops.
- the other characteristics exhibited by the composition of the present invention are mainly as follows: 1.
- the composition of the present invention has a synergistic additive effect and can promote each other; 2 due to the difference in chemical composition of the two single agents of the composition Large, the mechanism of action is completely different, there is no cross-resistance, the crop is safe, and the disease-preventing effect can be greatly improved; 3 the composition reduces the adverse effects caused by the application of the medicine to the crop; Recovery from disease infestation; 4 The composition can improve crop yield, improve quality, and has high economic and social value.
- the active ingredient and the auxiliary agent are mixed according to a certain ratio, and then finely ground to obtain a water-dispersible granule.
- Example 3 75% thiabendazole-propionyl carbazole wettable powder
- Example 4 42% thidiazuron- tebuconazole wettable powder
- Example 5 56% thiabendazole-conazole alcohol wettable powder
- Example 6 75% thiablon ⁇ tebuconazole wettable powder
- Example 7 50% thiabendazole-propanthioxazole suspension
- Example 12 64% thiabendazole-pentazole suspension
- the active ingredients thiabendazole and triacontanol are mixed in proportion to the solvent, emulsifier and flow, and after fine sanding and high-speed shearing, a semi-finished product is obtained, which is processed into a finished product.
- Example 17 22% thiabendazole- tebuconazole aqueous emulsion
- Example 18 12% thiabendazole- tebuconazole aqueous emulsion
- the surfactant is mixed with the oil base and mixed in proportion, and the active ingredient thiabendazole, prothioconazole or tebuconazole is added under shearing and stirring, and ground in a sand mill and ground until a certain range of particles The path is fine.
- Example 21 12% thiablon ⁇ tebuconazole dispersible oil suspension
- Example 22 33% thiabendazole- tebuconazole dispersible oil suspension
- the thidiazepine and tebuconazole and prothioconazole were diluted according to a certain concentration, and the crops were sprayed to measure the effects of various concentrations on crop growth in the field, including plant height, rust control effect, powdery mildew control effect and Comprehensive evaluation of production conditions, etc.
- Plant height increase rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
- Starch content increase rate (treated starch content - starch content of clear water control) / starch content of clear water control * 100%
- 1000-grain weight increase rate (1000-grain weight after treatment - 1000-grain weight of clear water control) / 1000-grain weight of clear water control * 100%
- Table 1 Summary of thiazolone, prothioconazole and tebuconazole in wheat growth regulation and disease prevention
- thidiazepine has a good synergistic effect between one of prothioconazole and tebuconazole, and thiabendazole is mixed with it at different ratios, relative to thidiazuron and propionate.
- the combination of azole and tebuconazole, as well as the clear water control has obvious effects on wheat, mainly in controlling wheat plant height and improving wheat disease resistance; when wheat powdery mildew and rust infest wheat, the composition is used to treat wheat. It can significantly improve the disease prevention effect; quickly restore wheat from infection, increase wheat 1000-grain weight, increase yield; regulate wheat growth quality and increase wheat starch content; spray the composition of the invention, the incidence rate is greatly reduced, and the prevention Disease effect.
- the thidiazepine and one of prothioconazole and tebuconazole were diluted according to a certain concentration, and the crops were sprayed to determine the effects of various concentrations on crop growth in the field, including the control effect on peanut plant height, leaf spot and rust. And comprehensive evaluation of the production situation.
- Plant height increase rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
- Protein content increase rate (treated protein content - protein content of clear water control) / protein content of clear water control * 100%
- the experimental data from Table 2 shows that the product of the present invention is applied in the early stage of peanut leaf spot disease and rust, and can effectively reduce the disease index and improve the control effect when the disease occurs; can effectively promote the growth of peanut, increase the protein content of peanut, and enhance the peanut. Quality, increase production.
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Abstract
提供了一种农药组合物，特别是一种具有增效作用的植物生长调节剂组合物。该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B选自丙硫菌唑或戊唑醇中的一种，两组分之间的重量比为活性组分A和活性组分B的重量比为1：(250～2)。该农药组合物可协同促进作物生长，防治作物病害发生，快速控制作物病害蔓延，提高作物产量，达到抗病增产的目的。
Description
本发明主要应用于农业植保领域的农药组合物，包含活性成分噻苯隆与丙硫菌唑或戊唑醇其中一种。
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，从而促进成熟叶片脱落，较高的浓度下可刺激乙烯的生成，促进果胶和纤维素酶的活性。低浓度的条件下，具有细胞动素作用，能诱导植物的愈伤组织分化出芽出来。结构式如下：
丙硫菌唑的作用机理是抑制真菌中甾醇的前体一一羊毛甾醇或24-亚甲基二氢芈毛醉l4位上的脱甲基化作用，即脱甲基化抑制剂(DMIs)。不仅具有很好的内吸活性，优异的保护、治疗和铲除活性，且持效期长。通过大量的田间药效试验，结果表明丙硫菌唑对作物不仅具有良好的安全性，防病治病效果好，而且增产明显，同三唑类杀茵剂相比，丙硫菌唑具有更广谱的杀菌活住。丙硫菌唑主要用于防治禾谷类作物如小麦、大麦、油菜、花生、水稻和豆类作物等众多病害。儿乎对所有麦类病害都有很好的防治效果，如小麦和大麦的白粉病、纹枯病、枯萎病、叶斑病、锈病、菌核病、网斑病、云纹病等。还能防治油莱和花生的土传病害，如菌核病，以及主要叶面病害，如灰霉病、黑斑病、褐斑病、黑胫病、菌核病和锈病等。结构式如下：
戊唑醇是一种高效、广谱、内吸性三唑类杀菌农药，具有保护、治疗、铲除三大功能，杀菌谱广、持效期长。青岛浩瀚高科专家组与新西兰技术专家研究发现：与所有的三唑类杀菌剂一样,戊唑醇能够抑制真菌的麦角甾醇的生物合成。
戊唑醇在全世界范围内用作种子处理剂和叶面喷雾,杀菌谱广,不仅活性高,而且持效期长。戊唑醇主要用于防治小麦、水稻、花生、蔬菜、香蕉、苹果、梨以及玉米高粱等作物上的多种真菌病害,其在全球50多个国家的60多种作物上取得登记并广泛应用。该品用于防治油菜菌核病，不仅防效好，而且具有抗倒伏，增产作用明显等特点对病菌的作用机制为抑制其细胞膜上麦角甾醇的去甲基化，使得病菌无法形成细胞膜，从而杀死病菌。有关戊唑醇的合成研究很多,其中多以对氯甲醛为起始原料,经过醛酮缩合、催化加氢、环氧化反应、加成反应等步骤制备戊唑醇。结构式为：
发明内容
本发明的目的是提供一种农药组合物，可协同促进作物生长，防治作物病害发生，快速控制作物病害蔓延，提高作物产量，达到抗病增产的目的。通过试验发现，噻苯隆与丙硫菌唑或戊唑醇复配后，可调节作物生长，更好地防治作物病害，提高作物抗病原物侵染能力，达到抗病增产的目的。
本发明的另一个目的是提供包含两种有效成分A和B农用化合物组合的制备方法及在农业领域调节和促进农作物生长的应用。
本发明的目的可以通过以下措施达到：
本发明涉及一种农药组合物，特别是一种具有增效作用的植物生长调节剂组合物，该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B选自丙硫菌唑或戊唑醇中的一种，两组分之间的重量比为活性组分A和活性组分B的重量比为1：(250～2)。活性组分B为三唑类农药。
在一种优选方案中，活性组分A和活性组分B的重量比为为1：(200～5)，为使作用效果更明显两者重量比可进一步优选1：(150～5)、1：(120:5)或1：(200～50)。。进一步，活性组分噻苯隆和活性组分丙硫菌唑的重量比为1：150～10；活性组分噻苯隆和活性组分戊唑醇的重量比为1：180～10。
一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调
整：1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、1：12、1：13、1：14、1：15、1：16、1：17、1：18、1：19、1：20、1：21、1：22、1：23、1：24、1：25、1：26、1：27、1：28、1：29、1：30，1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:40、1:41、1:42、1:43、1:44、1:45、1:46、1:47、1:48、1:49、1:50、1:51、1:52、1:53、1:54、1:55、1:56、1:57、1:58、159:、1:60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:68、1:69、1:70、1:71、1:72、1:73、1:74、1:75、1:76、1:77、1:78、1:79、1:80、1:81、1:82、1:83、1:84、1:85、1:86、1:87、1:88、1:89、1:90、1:91、1:92、1:93、1:94、1:95、1:96、1:97、1:98、1:99、1:100、1:110、1:120、1:130、1:140、1:150、1:160、1:170、1:180、1:190、1:200、1:210、1:220、1:230、1:240、1:250,也可以在以上任意两个配比所组成的范围内进行选择这些比例可以理解为重量比，也可以包括摩尔比。
本发明通过试验发现，该组合物是用于可以更好的防治作物病害，当作物受到病菌侵染时，使用该化合物处理作物，可更好更快速地控制病害传播，可促进作物的健康作用，增强作物的抗病能力和提升作物的产品的质量品质。
本发明提供了包含组分A(噻苯隆)和组分B(丙硫菌唑或戊唑醇)的组合物在农业领域调节农作物生长的用途，特别是在防治小麦、油菜及花生等作物病害方面、提高抗病性、调节作物生长、增加产量、提高品质等方面的用途。
为充分发挥本发明的作用效果，本发明组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。
本发明的组合物可以由活性成分和农药助剂制成农药上允许的剂型。
在一种优选方案中，该组合物中的活性成分的质量含量为5-85％，优选5-60％。
上述组合物具体可包含农药助剂，例如载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂等中的一种或几种，在施用的过程中可以混合常用的助剂。
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体
内(内吸作用)。
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合使用。
本发明的组合物可以制备成农药上可接受的剂型，例如水剂、悬浮剂、可溶性液剂、油悬浮剂、微囊剂型、微乳剂、悬浮剂等。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。
适合本发明的微囊剂型包括：微囊悬浮剂、微囊悬浮-悬浮剂、微囊悬浮-水乳剂等，其特征在于囊壁内(即囊芯)包含由有效成分按照一定比例的混合物，即将两者混合制成微型胶囊。将微型胶囊以一定的浓度稳定地分散、悬浮在作为连续相的水中形成微囊悬浮剂。或者将其中一种有效成分制备成微囊悬浮剂，将另外一种有效成分制备成乳液，将制备的两种成分在混合，搅拌，摇匀即得微囊悬浮剂-悬浮剂或微囊悬浮剂-水乳剂。
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环已烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环已酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。
上述的固体载体，如用于悬浮剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。
本发明的组合物可应用在农业领域调节作物生长及防治作物病害方面。
本发明中的植物或作物包括但不限于小麦、油菜或花生等。
本发明的组合物中两种有效成分表现为互相促进作用，该组合物的活性比使用单个化合物的活性预期总和，本发明物中植调剂可促进植物生长调节，杀菌剂组分可以有效地杀灭病原物。在作物发生病害时，用该组合物处理作物，组合物中的杀菌剂可有效防治病原物的扩散与传播，可有更好更快地防治作物病害，组合物中的植物生长调节剂调节作物生长，提高作物生长活性，减轻因用药给作物带来的影响。本发明的组合物的表现出的其它特点主要表现为：1、本发明的组合物混配具有明显的协同相加作用，可相互促进效果；2由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，对作物安全，且可较大提升的防病效果；3本组合物减少因用药给作物生长带来的不良影响；，可使作物快速从病害侵染中恢复；4本组合物可提高作物产量，提升品质，具有较高的经济价值和社会价值。
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比(折百)。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。
一、剂型制备实施例
(一)可湿性粉剂的加工及实施例
将有效成分和助剂按照一定比例进行混合，再进行细磨后即可制成水分散粒剂。
实施例1：42％噻苯隆·丙硫菌唑可湿性粉剂
噻苯隆0.2％，丙硫菌唑41.8％，十二烷基苯磺酸钠3％，木质素磺酸钙4％，膨润土35％，凹凸棒土补足至100％。
实施例2：56％噻苯隆·丙硫菌唑可湿性粉剂
噻苯隆0.4％，丙硫菌唑55.6％，拉开粉2％，膨润土1.5％，烷基聚氧乙基醚磺酸盐1％，白炭黑3％，硅藻土补足至100％。
实施例3:75％噻苯隆·丙硫菌唑可湿性粉剂
噻苯隆1％，丙硫菌唑74％，木质素磺酸钠5％，白炭黑5％，聚氧乙烯辛基苯基醚4％,硅藻土补足至100％。
实施例4：42％噻苯隆·戊唑醇可湿性粉剂
噻苯隆0.2％，戊唑醇41.8％，白炭黑5％，十二烷基苯磺酸钠6％，木质素磺酸钠5％，凹凸棒土补足至100％。
实施例5：56％噻苯隆·戊唑醇可湿性粉剂
噻苯隆0.4％，戊唑醇55.6％，十二烷基苯磺酸钠4％，拉开粉4％，膨润土7％，凹凸棒土补足至
100％。
实施例6:75％噻苯隆·戊唑醇可湿性粉剂
噻苯隆1％，戊唑醇74％，烷基聚氧乙基醚磺酸盐3％,拉开粉6％,膨润土4％，白炭黑4％，硅藻土补足至100％。
(二)悬浮剂加工及实施例
将有效成分噻苯隆和丙硫菌唑、戊唑醇与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。
实施例7：50％噻苯隆·丙硫菌唑悬浮剂
噻苯隆0.2％，丙硫菌唑49.8％，脂肪醇聚氧乙烯醚3％，苯乙基酚聚氧乙烯醚3％，乙二醇3％，异辛醇2％，海藻酸钠1％，阿拉伯胶0.2％。
实施例8：36％噻苯隆·丙硫菌唑悬浮剂
噻苯隆0.3％，丙硫菌唑35.7％，木质素磺酸钙5％，异丙二醇4％，聚萘甲醛磺酸钠盐4％，异辛醇4％，苯甲酸钠0.8％。
实施例9:64％噻苯隆·丙硫菌唑悬浮剂
噻苯隆0.4％，丙硫菌唑63.6％，烷基酚甲醛树脂聚氧乙烯醚3％，木质素磺酸钠4％，乙二醇3％，聚二甲基硅氧烷0.5％，黄原胶2％，苯甲酸钠0.7％，水补足至100％。
实施例10：50％噻苯隆·戊唑醇悬浮剂
噻苯隆0.2％，戊唑醇49.8％，乙基酚聚氧乙烯醚2％，改性木质素磺酸钙4％，丙二醇3％，异辛醇4％，苯甲酸钠0.1％。
实施例11：36％噻苯隆·戊唑醇悬浮剂
噻苯隆0.3％，戊唑醇35.7％，脂肪醇聚氧乙烯醚2％，聚萘甲醛磺酸钠盐4％，乙二醇4％，异辛醇1％，海藻酸钠1％，乳酸2％，水补足至100％。
实施例12:64％噻苯隆·戊唑悬浮剂
噻苯隆0.4％，戊唑醇63.6％，聚二甲基硅氧烷0.4％，木质素磺酸钙6％，烷烷基酚甲醛树
脂聚氧乙烯醚4％，乙二醇4％，黄原胶0.2％，苯甲酸钠0.2％，水补足至100％。
(三)水乳剂加工及实施例
将有效成分噻苯隆和三十烷醇与溶剂、乳化剂、流动相等按照比例混合，精磨砂和高速剪切后，得到半成品，在进行加工成成品。
实施例13：38％噻苯隆·丙硫菌唑水乳剂
噻苯隆0.4％，丙硫菌唑37.6％，6％甲醇、3％甲苯、11％二苄基联苯基聚氧乙烯醚，水补足至100％。
实施例14：22％噻苯隆·丙硫菌唑水乳剂
噻苯隆1％，丙硫菌唑21％，4％环己酮、3％二甲苯、12％十二烷基苯磺酸钙，水补足至100％。
实施例15：12％噻苯隆·丙硫菌唑水乳剂
噻苯隆0.2％，丙硫菌唑11.8％，5％甲醇、3％二甲苯、8％二苄基联苯基聚氧乙烯醚，水补足至100％。
实施例16：38％噻苯隆·戊唑醇水乳剂
噻苯隆0.4％，戊唑醇37.6％，4％环己酮、2％二甲苯、十二烷基苯磺酸钙20％，水补足至100％。
实施例17：22％噻苯隆·戊唑醇水乳剂
噻苯隆1％，戊唑醇21％，5％环己酮、5％二甲苯、苯乙烯基苯基聚氧乙烯醚22％，水补足至100％。
实施例18：12％噻苯隆·戊唑醇水乳剂
噻苯隆0.2％，戊唑醇11.8％，、乙氧基化聚氧丙烯8％、烷基芳基聚乙二醇醚10％,，水补足至100％。
(四)可分散油悬浮剂的加工及实施例
将表面活性剂与油基混合等按比例充分混合，在搞度剪切搅拌下加入活性成分噻苯隆、丙硫菌唑或戊唑醇,在砂磨机中研磨，研磨直到一定范围的粒径即可。
实施例19:9％噻苯隆·丙硫菌唑可分散油悬浮剂
噻苯隆3％，丙硫菌唑6％，黄原胶2％，木质素磺酸钠9％,矿物油补足至100％。
实施例20:22％噻苯隆·丙硫菌唑可分散油悬浮剂
噻苯隆2％，丙硫菌唑20％，烷基聚氧乙基醚磺酸盐5％,N-邻苯二甲酸二甲酯4％,大豆油补足至100％。
实施例21:12％噻苯隆·戊唑醇可分散油悬浮剂
噻苯隆4％，戊唑醇8％，芳基烷基磺酸钠3％，黄原胶2％，聚氧乙烯辛基苯基醚5％,矿物油补足至100％。
实施例22:33％噻苯隆·戊唑醇可分散油悬浮剂
噻苯隆3％，丙硫菌唑30％，十二烷基硫酸钾3％，,脂肪酸和硫酸化脂肪醇乙二醇醚5％，大豆油补足至100％。
二、药效验证试验
1、噻苯隆与戊唑醇、丙硫菌唑复配对小麦生长调节及防病综合测定试验
将噻苯隆与戊唑醇、丙硫菌唑按照一定浓度稀释，对作物进行喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、锈病防效、白粉病防效及产量情况等进行综合评价。
株高提高率＝(清水对照株高-处理后的株高)/清水对照株高*100％
防病效果提高率＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
淀粉含量提高率＝(处理的淀粉含量-清水对照的淀粉含量)/清水对照的淀粉含量*100％
千粒重提高率＝(处理后的千粒重-清水对照的千粒重)/清水对照的千粒重*100％
表1.噻苯隆与丙硫菌唑、戊唑醇其中之一复配对小麦生长调节及防病汇总表
注：施药时期：在小麦白粉病和锈病侵染初期施药。
通过实验发明人发现，噻苯隆与丙硫菌唑、戊唑醇其中之一之间具有很好协同提升作用，噻苯隆与与其混配在不同配比下，相对噻苯隆与丙硫菌唑、戊唑醇单剂，以及清水对照，对小麦的作用明显，主要表现在：控制小麦株高，提高小麦抗病能力；当白粉病和锈病侵染小麦时，用该组合物处理小麦，可显著提升防病效果；快速使小麦从侵染中恢复，增加小麦千粒重，提高产量；调节小麦生长品质，提高小麦淀粉含量；喷施该发明组合物后，发病率大幅度降低，提升防病效果。
2、噻苯隆与噻苯隆与丙硫菌唑、戊唑醇其中之一复配对花生的田间综合测定试验
将噻苯隆与丙硫菌唑、戊唑醇其中之一按照一定浓度稀释，对作物进行喷雾，在田间测定各个浓度对作物生长的影响，包括对花生株高、叶斑病、锈病防治效果及产量情况等进行综合评价。
株高提高率＝(清水对照株高-处理后的株高)/清水对照株高*100％
防病效果提高率＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
蛋白质含量提高率＝(处理的蛋白质含量-清水对照的蛋白质含量)/清水对照的蛋白质含量*100％
亩产提高率＝(处理后的亩产-清水对照的亩产)/清水对照的亩产*100％
表2.噻苯隆与丙硫菌唑、戊唑醇其中之一对花生生长调节及防病测定汇总表
从表2实验数据显示，本发明的产品在花生叶斑病及锈病发病初期施药，在病害发生时，可有效降低病情指数，提高防治效果；可有效促进花生生长提高花生蛋白质含量，提升花生品质，增加产量。
Claims (10)
- 一种农药组合物，其特征在于该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B选自丙硫菌唑或戊唑醇，活性组分A和活性组分B的重量比为1：250～2。
- 根据权利要求1所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：200～5。
- 根据权利要求1所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：200～50。
- 根据权利要求2所述的组合物，其特征在于活性组分噻苯隆和活性组分丙硫菌唑的重量比为1：150～10。
- 根据权利要求4所述的组合物，其特征在于活性组分噻苯隆和活性组分戊唑醇的重量比为1：180～10。
- 根据权利要求1、2、3或4所述的组合物，其特征在于该组合物由活性成分和助剂制成农药上允许的剂型。
- 根据权利要求6所述的组合物，其特征在于该组合物中的活性成分的质量含量为5～85％。
- 根据权利要求6所述的组合物，其特征在于所述剂型为可湿性粉剂、水分散粒剂、悬浮剂等农业领域允许剂型。
- 根据权利要求1、2、3、4或5任意一项所述的组合物在农业领域调节作物生长及防治作物病害的应用。
- 根据权利要求9所述的用途，其特征在于所述作物选自小麦、油菜或花生。
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| CN201610705617.2A CN106332893A (zh) | 2016-08-22 | 2016-08-22 | 一种农药组合物 |
| CN201610705617.2 | 2016-08-22 |
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| CN116158440A (zh) * | 2023-02-11 | 2023-05-26 | 河南农业大学 | 一种提高小麦千粒重的组合物 |
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| CN106332893A (zh) * | 2016-08-22 | 2017-01-18 | 江苏辉丰农化股份有限公司 | 一种农药组合物 |
| CN106922683A (zh) * | 2017-03-21 | 2017-07-07 | 江苏辉丰农化股份有限公司 | 含有苯并异噻唑啉酮和噻苯隆的农药组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN106332893A (zh) * | 2016-08-22 | 2017-01-18 | 江苏辉丰农化股份有限公司 | 一种农药组合物 |
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| CN102180871B (zh) * | 2011-03-24 | 2014-04-23 | 南开大学 | 4-甲基-1,2,3-噻二唑脲类衍生物及其制备方法和用途 |
| CN104936450A (zh) * | 2012-12-20 | 2015-09-23 | 巴斯夫欧洲公司 | 包含三唑化合物的组合物 |
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| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN106332893A (zh) * | 2016-08-22 | 2017-01-18 | 江苏辉丰农化股份有限公司 | 一种农药组合物 |
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| CN116158440A (zh) * | 2023-02-11 | 2023-05-26 | 河南农业大学 | 一种提高小麦千粒重的组合物 |
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