WO2018036288A1 - 一种农药组合物 - Google Patents
一种农药组合物 Download PDFInfo
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- WO2018036288A1 WO2018036288A1 PCT/CN2017/092235 CN2017092235W WO2018036288A1 WO 2018036288 A1 WO2018036288 A1 WO 2018036288A1 CN 2017092235 W CN2017092235 W CN 2017092235W WO 2018036288 A1 WO2018036288 A1 WO 2018036288A1
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- thiabendazole
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Definitions
- the invention is mainly applied to the field of agricultural plant protection, and is a composition of a plant growth regulator and a bactericide, and comprises an active ingredient thidiazuron and a pyridine fungicide.
- Pyraclostrobin is a new type of high-efficiency plant growth regulator. When thidiazepine is absorbed by plants, it can promote the separation of the petioles and stems, thus promoting the shedding of mature leaves. At higher concentrations, it can stimulate the formation of ethylene. Promotes the activity of pectin and cellulase. Under low concentration conditions, it has an cytokines effect and can induce plant callus differentiation and bud emergence.
- the structure is as follows:
- Fluramine (SHIRLAN, IKF-1216) is a new type of substituted aniline and broad-spectrum fungicide developed by Japan Ishihara Industry Co., Ltd. It has special effects on various gray mold caused by Botrytis cinerea. There is no cross-resistance with benzimidazoles, dicarboximides and fungicides currently available on the market. It also has good activity against diseases caused by pathogens such as Alternaria, Phytophthora, Trichoderma, Sclerotinia and Staphylococcus.
- Boridylamine is a new niacinamide fungicide developed by BASF, Germany. It is mainly used to control powdery mildew, gray mold, various rot diseases, brown rot and root rot. It was in the UK in 2004. Registered in Germany and Switzerland [1].
- Boridyl amide is a succinic acid coenzyme Q reductase inhibitor in the mitochondrial respiratory chain, which has strong inhibitory effect on spore germination and has no cross-resistance with other fungicides.
- Boscalid is a novel nicotinamide fungicide with a broad spectrum of bactericidal activity and is active against almost all types of fungal diseases.
- the object of the present invention is to provide a pesticide composition which can adjust crop growth and prevent crop diseases.
- the crop disease can be controlled, the crop growth can be adjusted, and the spread of crop diseases can be quickly controlled.
- Another object of the present invention is to provide a preparation method comprising a combination of two active ingredients A and B agricultural compounds and an application for regulating and promoting crop growth in the agricultural field.
- the object of the invention can be achieved by the following measures:
- the present invention relates to a pesticidal composition, in particular to a synergistic plant growth regulator composition comprising two active components A and B, wherein active component A is thidiazuron, active group
- active component A is thidiazuron, active group
- the fraction B is a pyridine fungicide, and the weight ratio between the two components is 1: (225 to 10) by weight of the active component A and the active component B.
- the active ingredient B is selected from fluazinam or boscalid.
- the weight ratio of the active component A to the active component B is 1: (200 to 5), and the active component A and the active component are further preferred in order to make the effect more apparent.
- the weight ratio of B is 1:200 to 10 or 1:180 to 50.
- the weight ratio of the active component thiabendazole to the active component fluazinam is 1:180 to 10; the weight ratio of the active component thiabendazole to boscalid is 1:180 to 10 .
- the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1:2, 1:3, 1:4, 1:5, 1:6 , 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1 :19, 1:20, 1:21, 1:22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30, 1:32 , 1:33, 1:34, 1:35, 1:36, 1:37, 1:38, 1:39, 1:40, 1:41, 1:42, 1:43, 1:44, 1 :45, 1:46, 1:47, 1:48, 1:49, 1:50, 1:51, 1:52, 1:53, 1:54, 1:55, 1:56, 1:57, 1:58, 159:, 1:60, 1:61, 1:62, 1:63, 1:64 , 1:65, 1:66
- the invention finds through experiments that the composition is used for better control of crop diseases.
- the treatment with the compound can better control the spread of the disease, promote the growth of the crop, and enhance the growth.
- the invention provides the use of a composition comprising component A (thiabendazole) and component B (pyridine bactericide) to regulate the growth of crops in the agricultural field, in particular to control diseases and improve disease resistance in pepper, potato or cabbage. Use for sex, regulating crop growth, increasing yield, and improving quality.
- component A thiabendazole
- component B pyridine bactericide
- composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with existing ones.
- pesticides such as fungicides, insecticides, herbicides, plant growth regulators
- fertilizers etc.
- composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and the pesticide adjuvant.
- the active ingredient in the composition has a mass content of from 5 to 85%, preferably from 5 to 60%.
- composition may specifically comprise an agrochemical auxiliary, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc., during the application process.
- an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
- an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
- Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
- the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
- the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
- the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
- compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
- compositions of the present invention may be prepared in a pesticide acceptable dosage form such as a liquid, suspension, soluble liquid, oil suspension, microcapsule, microemulsion, suspension, and the like. According to the nature of these compositions and the application of the composition For the purpose and environmental conditions, the composition may be applied by spraying, misting, dusting, spreading or pouring.
- Microcapsule dosage forms suitable for the present invention include: microcapsule suspension, microcapsule suspension-suspension, microcapsule suspension-water emulsion, etc., characterized in that the inner wall of the capsule (ie, the capsule core) contains the active ingredients of thidiazuron and pyridine.
- the bactericide is mixed in a certain proportion, that is, the two are mixed into a microcapsule.
- the microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase.
- one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension.
- Agent-water emulsion is a microcapsule suspension.
- composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
- the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
- ketones such as cyclohexanone
- highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
- vegetable or vegetable oils such as soybean oil.
- the above solid carriers are usually natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
- a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
- a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
- Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
- compositions of the present invention are useful in the agricultural sector, particularly in promoting crop growth or controlling crop diseases.
- Plants or crops of the invention include, but are not limited to, pepper, potato or cabbage, and the like.
- the two active ingredients in the composition of the present invention exhibit mutual promotion, the activity of the composition is higher than the expected activity of using a single compound, and the planting agent in the present invention can promote plant growth regulation, and the fungicide component can effectively kill Disease killer.
- the treatment of the crop with the composition can effectively prevent the spread and spread of the pathogen, and can better and better control the crop disease and reduce the impact of the medicine on the crop.
- the other characteristics exhibited by the composition of the present invention are mainly as follows: 1.
- the composition of the present invention has a synergistic additive effect and can promote each other; 2 due to the difference in chemical composition of the two single agents of the composition Large, the mechanism of action is completely different, there is no cross-resistance, the crop is safe, and the disease-preventing effect can be greatly improved; 3 the composition reduces the adverse effects caused by the application of the drug to the crop; 4 the composition can be improved Crop yield, quality improvement, and high economic value.
- the active ingredients thiabendazole and fluazinam, boscalid are mixed with the solvent, emulsifier and flow in proportion, and after fine sanding and high-speed shearing, a semi-finished product is obtained, which is processed into a finished product.
- Example 1 23% thiabendazole-fluridine aqueous emulsion
- Example 2 17% thiabendazole-fluridine aqueous emulsion
- Example 3 20% thiabendazole-fluridine aqueous emulsion
- Example 4 23% thiabendazole-pyridinamide aqueous emulsion
- Example 5 17% thiabendazole-pyridinamide aqueous emulsion
- Example 6 20% thiabendazole-pyridinamide aqueous emulsion
- the active ingredient thiablon is mixed with fluazinam, boscalid, various auxiliaries and fillers in proportion, and is pulverized by an ultrafine pulverizer, then granulated and then dried.
- Example 7 35% thiabendazole-fluridine water dispersible granules
- Example 8 51% thiabendazole-fluridine water dispersible granules
- Example 9 42% thiabendazole-fluridine water dispersible granules
- Example 10 35% thiabendazole-pyridinamide water-dispersible granules
- Example 11 51% thiabendazole-pyridinamide water-dispersible granules
- Example 12 42% thiabendazole-pyridinamide water-dispersible granules
- Example 13 27% thiabendazole-fluridine microemulsion
- Example 14 30% thiabendazole-fluridine microemulsion
- Example 15 8% thidiazuron fluazinam microemulsion
- Example 17 30% thiabendazole-pyridinamide microemulsion
- the active ingredient active group A and the active component B, and the components such as a dispersing agent, a wetting agent, a thickener and water are uniformly mixed according to the formula, and after being sanded and/or sheared at a high speed, a semi-finished product is obtained. After the analysis, the water is mixed and evenly filtered to obtain the finished product.
- Example 19 11% thiazolidine fluazinam suspension
- Example 20 12% thiabendazole-fluridine suspension
- Example 21 11% thiabendazole-pyridinamide suspension
- the thidiazepine and pyridine fungicides were diluted with acetone at a certain concentration, and the crops were sprayed to determine the effects of various concentrations on crop growth in the field, including plant height, disease control rate, anthracnose control rate and yield. Wait for a comprehensive evaluation.
- Plant height increase rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
- Rate of fruit set rate increase (the fruit set rate of treatment - fruit set rate of clear water control) / fruit set rate of clear water control * 100%
- Vitamin C content increase rate (vitamin C content after treatment - vitamin C content of clear water control) / vitamin C content of clear water control * 100%
- Table 1 Summary of thiazolone and pyridine fungicides paired with pepper growth regulation and disease prevention
- thiabendazole and pyridine fungicides have a good synergistic effect.
- the thiabendazole and pyridine fungicides are mixed at different ratios, and the thidiazuron and pyridine fungicides are single.
- the clear water control when the crop is infected by the pathogen, the composition is used to treat the infected crop, which can effectively prevent the pathogen from further infecting the crop, control the spread, eliminate the pathogen, and regulate the intrinsic growth of the crop. It can make the damage caused by pathogen infection from rapid recovery to pre-morbid state, improve crop yield and quality, and has high economic value.
- Dithizone and pyridine fungicides were diluted with acetone at a certain concentration, and the crops were sprayed to determine the effects of various concentrations on crop growth in the field, including plant height, early blight, late blight incidence and yield. Wait for a comprehensive evaluation.
- Plant height increase rate (grass control stem diameter - treated stem diameter) / clear water control stem thick * 100%
- Starch content increase rate (treated starch content - starch content of clear water control) / starch content of clear water control * 100%
- Mu yield increase rate (mu yield after treatment - yield per mu of clear water control) / mu yield of clear water control * 100%
- the product of the present invention is applied in the early stage of potato early blight and late blight, which can effectively reduce the disease index and improve the control effect; can effectively control the plant height; increase the starch content of the cucumber, and increase the yield of the potato and quality.
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Abstract
提供了一种农药组合物，该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B为吡啶类杀菌剂氟啶胺或啶酰菌胺，两组分之间的重量比为活性组分A和活性组分B的重量比为1：(225～10)。用该组合物处理作物时，既可防治作物病害发生，又可调节作物生长，可快速控制作物病害蔓延，提高作物产量，达到抗病增产的目的。
Description
本发明主要应用于农业植保领域，为植物生长调节剂和杀菌剂的组合物，包含活性成分噻苯隆和吡啶类杀菌剂类农药。
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，从而促进成熟叶片脱落，较高的浓度下可刺激乙烯的生成，促进果胶和纤维素酶的活性。低浓度的条件下，具有细胞动素作用，能诱导植物的愈伤组织分化出芽出来。结构式如下：
氟啶胺(SHIRLAN，IKF-1216)是由日本石原产业公司开发的新型取代苯胺类、广谱杀菌剂，对灰葡萄孢引起的多种灰霉病有特效。同苯并咪唑类、二羧酰亚胺类及目前市场上已有的杀菌剂无交互抗性。对交链孢属、疫霉属、单轴霉属、核盘菌属和黑星菌属等病菌引起的病害亦有良好的活性。
结构式为：
啶酰菌胺是由德国巴斯夫公司开发的新型烟酰胺类杀菌剂,主要用于防治白粉病、灰霉病、各种腐烂病、褐腐病和根腐病等,已于2004年在英国、德国和瑞士登记[1]。啶酰菌胺属于线粒体呼吸链中琥珀酸辅酶Q还原酶抑制剂,对孢子的萌发有很强的抑制能力,且与其它杀菌剂无交互抗性。啶酰菌胺是新型烟酰胺类杀菌剂，杀菌谱较广，几乎对所有类型的真菌病害都有活性，对防治白粉病、灰霉病、菌核病和各种腐烂病等非常有效，并且对其他药剂的抗性菌亦有效，主要用于包括油菜、葡萄、果树、蔬菜和大田作
物等病害的防治。与多菌灵、速克灵等无交互抗性。通过叶面渗透在植物中转移，抑制线粒体琥珀酸酯脱氢酶，阻碍三羧酸循环，使氨基酸、糖缺乏、能量减少，干扰细胞的分裂和生长，对病害有神经活性，具有保护和治疗作用。抑制孢子萌发、细菌管延伸、菌丝生长和孢子母细胞形成真菌生长和繁殖的主要阶段，杀菌作用由母体活性物质直接引起，没有相应代谢活性。与多菌灵、速克灵等无交互抗性。结构式为：
发明内容
本发明的目的是提供一种既可以调节作物生长又能防止作物病害的农药组合物，用该组合物处理作物时，即可防治作物病害发生，又可调节作物生长，可快速控制作物病害蔓延，提高作物产量，达到抗病增产的目的。通过试验发现，噻苯隆与吡啶类杀菌剂两者复配后在调节作物生长和防治作物病害，提高单面机产量方面有显著的效果。
本发明的另一个目的是提供包含两种有效成分A和B农用化合物组合的制备方法及在农业领域调节和促进农作物生长的应用。
本发明的目的可以通过以下措施达到：
本发明涉及一种农药组合物，特别是一种具有增效作用的植物生长调节剂组合物，该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B为吡啶类杀菌剂，两组分之间的重量比为活性组分A和活性组分B的重量比为1：(225～10)。活性组分B选自氟啶胺或啶酰菌胺。
在一种优选方案中，活性组分A和活性组分B的重量比为为1:(200～5)，为使作用效果更明显两者重量比可进一步优选活性组分A和活性组分B的重量比为1：200～10或1：180～50。在另一种方案中，活性组分噻苯隆和活性组分氟啶胺的重量比为1：180～10；活性组分噻苯隆和啶酰菌胺的重量比为1：180～10。
一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调整：1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、1：12、1：13、1：14、1：15、1：16、1：17、1：18、1：19、1：20、1：21、1：22、1：23、1：24、1：25、1：26、1：27、1：28、1：29、1：30，1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:40、1:41、1:42、1:43、1:44、1:45、1:46、1:47、1:48、1:49、1:50、1:51、
1:52、1:53、1:54、1:55、1:56、1:57、1:58、159:、1:60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:68、1:69、1:70、1:71、1:72、1:73、1:74、1:75、1:76、1:77、1:78、1:79、1:80、1:81、1:82、1:83、1:84、1:85、1:86、1:87、1:88、1:89、1:90、1:91、1:92、1:93、1:94、1:95、1:96、1:97、1:98、1:99、1:100、1:110、1:120、1:130、1:140、1:150、1:160、1:170、1:180、1:190、1:200、1:210、1:220、1:225,也可以在以上任意两个配比所组成的范围内进行选择这些比例可以理解为重量比，也可以包括摩尔比。
本发明通过试验发现，该组合物是用于可以更好的防治作物病害，当作物受到病菌侵染时，用该化合物处理可更好更快速地控制病害传播，可促进作物的生长作用，增强作物的抗病能力和提升作物的产品的质量品质。
本发明提供了包含组分A(噻苯隆)和组分B(吡啶类杀菌剂)的组合物在农业领域调节农作物生长的用途，特别是在辣椒、马铃薯或白菜方面防治病害、提高抗病性、调节作物生长、增加产量、提高品质等方面的用途。
为充分发挥本发明的作用效果，本发明组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。
本发明的组合物可以由活性成分和农药助剂制成农药上允许的剂型。
在一种优选方案中，该组合物中的活性成分的质量含量为5-85％，优选5-60％。
上述组合物具体可包含农药助剂，例如载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂等中的一种或几种，在施用的过程中可以混合常用的助剂。
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合使用。
本发明的组合物可以制备成农药上可接受的剂型，例如水剂、悬浮剂、可溶性液剂、油悬浮剂、微囊剂型、微乳剂、悬浮剂等。根据这些组合物的性质以及施用组合物所要达
到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。
适合本发明的微囊剂型包括：微囊悬浮剂、微囊悬浮-悬浮剂、微囊悬浮-水乳剂等，其特征在于囊壁内(即囊芯)包含由有效成分噻苯隆和吡啶类杀菌剂按照一定比例的混合物，即将两者混合制成微型胶囊。将微型胶囊以一定的浓度稳定地分散、悬浮在作为连续相的水中形成微囊悬浮剂。或者将其中一种有效成分制备成微囊悬浮剂，将另外一种有效成分制备成乳液，将制备的两种成分在混合，搅拌，摇匀即得微囊悬浮剂-悬浮剂或微囊悬浮剂-水乳剂。
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环已烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环已酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。
上述的固体载体，如用于悬浮剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。
本发明的组合物可应用在农业领域，特别是促进作物生长或防治作物病害方面。本发明中的植物或作物包括但不限于辣椒、马铃薯或白菜等。
本发明的组合物中两种有效成分表现为互相促进作用，该组合物的活性比使用单个化合物的活性预期总和，本发明物中植调剂可促进植物生长调节，杀菌剂组分可以有效地杀
灭病原物。在作物发生病害时，用该组合物处理作物，可有效防治病原物的扩散与传播，可有更好更快地防治作物病害，减轻因用药给作物带来的影响。本发明的组合物的表现出的其它特点主要表现为：1、本发明的组合物混配具有明显的协同相加作用，可相互促进效果；2由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，对作物安全，且可较大提升的防病效果；3本组合物减少因用药给作物生长带来的不良影响；4本组合物可提高作物产量，提升品质，具有较高的经济价值。
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比(折百)。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。
一、剂型制备实施例
(一)水乳剂的加工及实施例
将有效成分噻苯隆和氟啶胺、啶酰菌胺与溶剂、乳化剂、流动相等按照比例混合，精磨砂和高速剪切后，得到半成品，在进行加工成成品。
实施例1：23％噻苯隆·氟啶胺水乳剂
噻苯隆0.1％，氟啶胺22.9％，5％环己酮、6％二甲苯、12％十二烷基苯磺酸钙，水补足至100％。
实施例2：17％噻苯隆·氟啶胺水乳剂
噻苯隆0.2％，氟啶胺16.8％，3％甲醇、6％二甲苯、4％二苄基联苯基聚氧乙烯醚，水补足至100％。
实施例3:20％噻苯隆·氟啶胺水乳剂
噻苯隆0.1％，氟啶胺19.9％，3％环己酮、6％酞酸二辛酸、9％苯乙烯基苯基聚氧乙烯醚，水补足至100％。
实施例4：23％噻苯隆·啶酰菌胺水乳剂
噻苯隆0.1％，啶酰菌胺22.9％，4％环己酮、3％酞酸二辛酸、12％十二烷基苯磺酸钙，水补足至100％。
实施例5：17％噻苯隆·啶酰菌胺水乳剂
噻苯隆0.2％，啶酰菌胺16.8％，4％甲醇、2％二甲苯、8％二苄基联苯基聚氧乙烯醚，水补足至100％。
实施例6:20％噻苯隆·啶酰菌胺水乳剂
噻苯隆0.1％，啶酰菌胺19.9％，5％环己酮、3％二甲苯、12％苯乙烯基苯基聚氧乙烯醚，水补足至100％。
(二)水分散粒剂加工及实施例
将有效成分噻苯隆与氟啶胺、啶酰菌胺与各种助剂及填料等按比例充分混合，经超细粉碎机粉碎后造粒再干燥。
实施例7：35％噻苯隆·氟啶胺水分散粒剂
噻苯隆0.2％，氟啶胺34.8％，木质素磺酸钠3％，聚氧化烯芳基苯醚硫酸钠4％，碳酸钙8％，白碳黑补充至100％。
实施例8：51％噻苯隆·氟啶胺水分散粒剂
噻苯隆0.5％，氟啶胺50.5％，脂肪醇聚氧乙烯醚3％，十二烷基苯磺酸钙2％，碳酸镁3％，高岭土补充至100％。
实施例9:42％噻苯隆·氟啶胺水分散粒剂
噻苯隆0.3％，氟啶胺41.7％，烷基磺基琥珀酸钠4％，碳酸钠3％，淀粉补充至100％。
实施例10：35％噻苯隆·啶酰菌胺水分散粒剂
噻苯隆0.2％，啶酰菌胺34.8％，萘磺酸盐和烷基取代萘磺酸盐与甲醛的缩合物7％，碳酸氢钠5％，磷酸钠6％，粘土补充至100％。
实施例11：51％噻苯隆·啶酰菌胺水分散粒剂
噻苯隆0.5％，啶酰菌胺50.5％，碳酸氢钾5％，十二烷基萘磺酸钠8％，蔗糖补充至100％。
实施例12:42％噻苯隆·啶酰菌胺水分散粒剂
噻苯隆0.3％，啶酰菌胺41.7％，月桂酸钠4％，碳酸钾6％，高岭土补充至100％。
(三)微乳剂将有效成分噻苯隆和氟啶胺、啶酰菌胺与溶剂、乳化剂、流动相等按照比例混合，精磨砂和高速剪切后，得到半成品，在进行加工成成品。
实施例13：27％噻苯隆·氟啶胺微乳剂
噻苯隆0.4％，氟啶胺26.6％，环己酮2％、甲基萘磺酸钠甲醛缩合物4％，十二烷基硫酸钾6％，，水补足至100％。
实施例14：30％噻苯隆·氟啶胺微乳剂
噻苯隆1％，氟啶胺29％，甲醇6％、异丙二醇2％、二苄基联苯基聚氧乙烯醚15％，水补足至100％。
实施例15：8％噻苯隆·氟啶胺微乳剂
噻苯隆0.4％，氟啶胺7.6％，环己酮5％、酞酸二丁酯7％、苯乙烯基苯基聚氧乙烯醚22％，水补足至100％。
实施例16：27％噻苯隆·啶酰菌胺微乳剂
噻苯隆0.4％，啶酰菌胺26.6％，环己酮3％、硅酸铝镁7％，黄原胶6％，水补足至100％。
实施例17：30％噻苯隆·啶酰菌胺微乳剂
噻苯隆1％，啶酰菌胺29％，乙醇醇6％、二甲苯4％、二苄基联苯基聚氧乙烯醚15％，水补足至100％。
实施例18：8％噻苯隆·啶酰菌胺微乳剂
噻苯隆0.4％，啶酰菌胺7.6％，环己酮5％、酞酸二丁酯7％、三丁基苯聚乙二醇醚22％，水补足至100％。
(四)悬浮剂的加工及实施例
将活性成分活性分组A与活性组分B，与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。
实施例19：11％噻苯隆·氟啶胺悬浮剂
噻苯隆1％，氟啶胺10％，黄原胶6％，膨润土4％，硅酸铝镁6％，乙二醇3％，木质素磺酸钠2％,水补足至100％。
实施例20：12％噻苯隆·氟啶胺悬浮剂
噻苯隆2％，氟啶胺10％，丙二醇6％，膨润土4％，甲基萘磺酸钠甲醛缩合物8％，水补足至100％。
实施例21：11％噻苯隆·啶酰菌胺悬浮剂
噻苯隆1％，啶酰菌胺10％，白炭黑5％，丙三醇2％，苯甲酸钾4％，脂肪醇聚氧乙烯醚磷酸酯6％,水补足至100％。
实施例22：12％噻苯隆·啶酰菌胺悬浮剂
噻苯隆2％，啶酰菌胺10％，木质素磺酸钠3％,乙二醇7％，膨润土4％，黄原胶2％，水补足至100％。
二、药效验证试验
1、噻苯隆与吡啶类杀菌剂复配对辣椒生长调节及防病综合测定试验
将噻苯隆与吡啶类杀菌剂用丙酮按照一定浓度稀释，对作物进行喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、疫病防治率、炭疽病防治率及产量情况等进行综合评价。
株高提高率＝(清水对照株高-处理后的株高)/清水对照株高*100％
防病效果提高率＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
坐果率提高率＝(处理的座果率-清水对照的座果率)/清水对照的座果率*100％
维生素C含量提高率＝(处理后的维生素C含量-清水对照的维生素C含量)/清水对照的维生素C含量*100％
表1.噻苯隆与吡啶类杀菌剂复配对辣椒生长调节及防病汇总表
注：施药时期：在辣椒疫病和炭疽病发病初期施药。
通过实验发明人发现，噻苯隆与吡啶类杀菌剂之间具有很好协相互促进作用，噻苯隆与吡啶类杀菌剂混配在不同配比下，相对噻苯隆、吡啶类杀菌剂单剂，以及清水对照，在作物受到病原物侵染时，用该组合物处理受侵染作物，能够有效防治该病原物对作物的进一步侵染，控制传播，消灭病原物，调节作物内在生长，可使作物从病原物侵染造成的伤害从快速恢复到发病前状态，提高作物产量和品质，具有较高的经济价值。
2、噻苯隆与吡啶类杀菌剂混配对马铃薯的田间综合试验
将噻苯隆与吡啶类杀菌剂类用丙酮按照一定浓度稀释，对作物进行喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、早疫病、晚疫病发病率及产量情况等进行综合评价。
株高提高率＝(清水对照茎粗-处理后的茎粗)/清水对照茎粗*100％
防病效果提高率＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
淀粉含量提高率＝(处理的淀粉含量-清水对照的淀粉含量)/清水对照的淀粉含量*100％
亩产量提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表2.噻苯隆与吡啶类杀菌剂类复配对马铃薯的综合测定汇总表
从表2实验数据显示，本发明的产品在马铃薯早疫病、晚疫病发病初期施药，可有效降低病情指数，提高防治效果；可有效控制株高；提高黄瓜的淀粉含量，提升马铃薯的产量及品质。
Claims (10)
- 一种农药组合物，其特征在于该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B选自氟啶胺或啶酰菌胺，活性组分A和活性组分B的重量比为1：225～5。
- 根据权利要求1所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：200～10。
- 根据权利要求2所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：180～50。
- 根据权利要求2所述的组合物，其特征在于活性组分噻苯隆和活性组分氟啶胺的重量比为1：180～10。
- 根据权利要求2所述的组合物，其特征在于活性组分噻苯隆和啶酰菌胺的重量比为1：180～10。
- 根据权利要求1所述的组合物，其特征在于该组合物由活性成分和助剂制成农药上允许的剂型。
- 根据权利要求6所述的组合物，其特征在于该组合物中的活性成分的质量含量为5～85％。
- 根据权利要求6所述的组合物，其特征在于所述剂型为水乳剂、微乳剂、水分散粒剂等农业领域允许剂型。
- 权利要求1～6中任意一项所述的组合物在农业领域的应用。
- 权利要求1～6中任意一项所述的组合物在促进作物生长或防治作物病害方面的应用，所述作物选自辣椒、马铃薯或白菜作物。
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| CN106922683A (zh) * | 2017-03-21 | 2017-07-07 | 江苏辉丰农化股份有限公司 | 含有苯并异噻唑啉酮和噻苯隆的农药组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN106305751A (zh) * | 2016-08-22 | 2017-01-11 | 江苏辉丰农化股份有限公司 | 一种农药组合物 |
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| CA2459698C (en) * | 2001-09-07 | 2010-02-23 | Syngenta Participations Ag | Surfactant systems for agriculturally active compounds |
| CN101292663A (zh) * | 2007-04-28 | 2008-10-29 | 江苏辉丰农化股份有限公司 | 一种含有甲基磺草酮的除草组合物 |
| WO2014079841A1 (en) * | 2012-11-22 | 2014-05-30 | Basf Se | Pesticidal mixtures |
| BR112015014555A2 (pt) * | 2012-12-19 | 2017-07-11 | Dow Agrosciences Llc | composições pesticidas e processos relacionados a isso |
| CN104798798A (zh) * | 2014-01-26 | 2015-07-29 | 沈阳化工研究院有限公司 | 一种二元组合物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008071714A1 (en) * | 2006-12-15 | 2008-06-19 | Rohm And Haas Company | Mixtures comprising 1-methylcyclopropene |
| CN106305751A (zh) * | 2016-08-22 | 2017-01-11 | 江苏辉丰农化股份有限公司 | 一种农药组合物 |
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