WO2018020141A1

WO2018020141A1 - Device for adsorbing odours

Info

Publication number: WO2018020141A1
Application number: PCT/FR2017/052068
Authority: WO
Inventors: Aurélie THULEAU; Isabelle FROMANTIN; Vincent Semetey; José DUGAY; Jean-François LE MEUR
Original assignee: Institut Curie; Ecole Superieure De Physique Et De Chimie Industrielle (Espci); Ecole Nationale Superieure De Chimie De Paris (Enscp); Centre National De La Recherche Scientifique; Cemag Consulting
Priority date: 2016-07-26
Filing date: 2017-07-25
Publication date: 2018-02-01
Also published as: FR3054448B1; PT3490623T; PL3490623T3; ES2930126T3; BR112019001559A2; DK3490623T3; CA3031327C; US11439724B2; HUE060447T2; KR20190045177A; US10772985B2; FR3054448A1; CA3031327A1; EP3490623A1; JP2019528101A; AU2017303694B2; US20190269813A1; AU2017303694A1; EP3490623B1; US20200376155A1

Abstract

The invention concerns a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.

Description

Device for the adsorption of odors

Introduction

The invention relates to a device for reducing odors, and in particular body odors, comprising at least one adsorbent spice. The invention more particularly relates to a device for medical or paramedical use for the adsorption of body odor, such as those emanating from necrosis, pus, defecation, urine, exudates, blood, blood sweat, etc. The invention also relates to the use of such a device in the form of a dressing, diaper, hygienic protection, absorbent pad or pantiliner to adsorb and mask odors. The invention also relates to the use of an adsorbent spice as an adsorbent in a device for adsorbing odors.

Many odors are likely to emanate permanently from a human or animal body. Among these odors, some can be perceived in negative ways by the individual from whom they emanate and / or his entourage. The unpleasant, even repulsive sensation associated with such odors can have a dramatic sociological impact on an individual's life. This is particularly the case of bad odors emanating from chronic wounds, the pregnance of which causes considerable discomfort for the patients as for their entourage. To a lesser extent, people suffering from urinary and / or faecal incontinence, or who have had an intestinal or digestive stoma may also experience discomfort related to the emanation of unpleasant odors.

Various devices have been developed, mainly based on activated charcoal, to allow the adsorption of odors and to improve the quality of life of individuals confronted with such problems of uncontrollable emanation of odors and whose cause can not necessarily be treated quickly. In particular, a dressing is known which is intended to be applied to a malodorous wound, composed of activated carbon covered with a nonwoven nylon envelope (Actisorb®). Activated carbon, although known for its adsorbent properties, does not always give satisfaction in the case of very marked odors, such as odors emanating from necrotic, infected or tumor wounds.

Faced with the inability of current devices to satisfactorily control the emanation of foul odors, especially in certain clinical situations, there is a real need for an alternative solution (and not an antibiotic) to improve the comfort of patients. people likely to emit such odors and their surroundings. Summary of the invention

By working on this problem, the inventors have surprisingly discovered that certain spices have particularly interesting adsorbent capacities which make it possible to very satisfactorily reduce bad smells and especially odors emanating from foul smelling wounds. In contrast, unlike activated carbon, spices not only adsorb a large portion of odorous emanations, but also cover or hide those that may not be fully adsorbed. The inventors have thus developed a device incorporating at least one spice, in the form of a powder, adsorbing odors and allowing, when in contact with or near the source of unpleasant odors, to reduce or even eliminate discomfort. user and his entourage vis-à-vis these smells. This is particularly the case with spices such as cinnamon, turmeric or clove which, in the form of powder, have adsorbent and masking properties particularly suited to remove or greatly reduce the nauseating body odor and discomfort associated with their emanations. The invention therefore relates to a device for adsorbing odors comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and a particulate adsorbent charge comprising at least one spice.

The invention also relates to the use of a spice, preferably cinnamon, as an adsorbent in a device for the adsorption of odors, including body odors. The spice is advantageously in powder form.

The subject of the invention is also the use of an adsorbent layer comprising a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one odorous spice, for the adsorption of odors, and in particular of body odor.

Description of figures

FIG. 1: Comparison of the adsorbent properties of activated charcoal (Actisorb®), a cinnamon powder, a turmeric powder and a clove powder, which can be used in the device according to the invention , on three characteristic VOCs of smelly necrosis, dimethyldisulphide - DMDS (A), phenol - Ph (B) and indole - In (C), the Control representing the VOC considered (100% abundance); Figure 2: Comparison of the VOCs emitted by (A) Actisorb® activated carbon, (B) two cinnamon powders of different provenances FV (Ceylon cinnamon) and FI, (C) a powder of turmeric and (D) a powder of clove, which can be used in the device according to the invention. The chromatographic profiles were obtained by an analysis method coupling a solid-phase microextraction (SPME) in headspace mode (HS) managed by a PLC (sample changer arm), to a gas chromatography (GC) with single quadrupole mass spectrometry (MS) detection;

Figure 3: Blind sensory tests for assessing the intensity of odor on a panel of users associated with smelly VOCs: (A) Control; (B) activated charcoal (Actisorb®); (C) cinnamon powder (Ceylon Cinnamon); (D) Turmeric powder (Curcuma longa); (E) TO clove powder, 24 hours and 48 hours after application to Maroille cheese;

Figure 4: Blind sensory testing of odor qualification associated with smelly VOCs on a panel of users: (A) Control; (B) activated charcoal (Actisorb®); (C) cinnamon powder (Ceylon Cinnamon); (D) Turmeric powder (Curcuma longa); (E) TO clove powder, 24 hours and 48 hours after application to Maroille cheese;

Figure 5: Blind sensory tests of association of odor associated with smelly VOCs on a panel of users: (A) Control; (B) activated charcoal (Actisorb®); (C) cinnamon powder (Ceylon Cinnamon); (D) Turmeric powder (Curcuma longa); (E) clove powder at T0, T24 hours and T48 hours after application to Maroille cheese.

Figure 6: Blind sensory tests to evaluate the intensity of the odor on a panel of users associated with foul smelling VOCs at T0, T24 hours and T48 hours after application on Maroille cheese of activated carbon (Actisorb ®), or different cinnamon powders (FV, FC, FI and W).

detailed description

The invention is mainly based on the discovery that spices can advantageously replace activated carbon, nowadays very widely used as adsorbent, in a device for the adsorption of odors, in order to adsorb and mask odors and especially body odor. More particularly, the invention proposes using at least one spice in the form of a powder, and preferentially cinnamon, the nail of clove and / or turmeric, as an adsorbent for reducing odors, in particular by incorporating the spice powder (s) in a device intended to be placed in contact with or near a source of foul odors. According to the invention, the spice is integrated and maintained in the device in powder form. In the context of the invention, a "spice" refers to an odoriferous substance of vegetable origin.

The principle of adsorption is a surface phenomenon by which atoms or molecules of gas or liquid are fixed on a solid, adsorbent surface. In the context of the invention, the term "adsorbent" means the ability to set volatile organic compounds (VOCs), so that these VOCs do not propagate or only slightly in the air. The odors associated with the emanation of these VOCs are then reduced or even eliminated. More particularly, an "adsorbent spice" is a spice which, in the form of a powder, is capable of adsorbing at least 20%, 30%, 40%, preferably at least 50%, more preferably at least 60% by weight. at least one VOC from dimethyldisulphide (DMDS), phenol (Ph) and indole (In). In the context of the invention, the percentage, or rate of adsorption of a spice is measured by depositing said spice in a tube containing the VOCs and with reference to a control tube also containing the 3 VOCs but containing no spice, according to the formula: adsorption rate = [(peak area COV control tube) - (peak area COV tube with spice)] / (peak area COV control tube) According to the invention, the chromatographic profiles are obtained by a chromatographic method coupling solid phase micro-extraction (SPME) in headspace mode (HS) to gas chromatography (GC) associated with mass spectrometry (MS) detection (HS-SPME-GC-MS coupling) (Preti et al., Journal of Chromatography B 2009, vol 877, pp 2011-2018, Rey et al., International Journal of Greenhouse Gas Control 2013, vol 19, no 11, pp. 576-583).

By "particulate filler" or "powder" is meant a solid material in the form of macroscopic particles. According to the invention, the particulate filler comprises or consists of a spice, in powder form, the particle size of which is advantageously less than

"Granulometry" refers to the particle size distribution of the particulate filler, and more particularly the spice, considered. The granulometry can be measured by dry sieving, wet sieving, sedimentometry, laser diffraction, microscopy, etc. The average particle size corresponds to the average particle diameter calculated from a volume distribution. More precisely, the arithmetic mean diameter (da) was calculated for a sample divided into n classes of representative diameters d according to the formula:

i = class of particles, Ni = number or percentage of particles in class

In one embodiment, the particulate filler consists of a spice powder whose average particle size is less than ΙΟΟΟμιη, 900μιη, 800μιη, 700μιη, 600μιη, 500μιη, 400μιη, 300μιη, 200μιη, 150μιη, ΙΟΟμιη, 90μιη, 80μιη , 70 μιη, 60 μιη, 50 μιη, 40 μιη. In particular, the particle load can be between ΙΟμιη and ΙΟΟΟμιη, 700 and 900μιη, 800 and 900μιη, 40 and 400 μιη, between 50 and 380 μιη, between 40 and 100 μιη, between 50 and 60 μιη. For example, the particulate filler has an average particle size of 52 μιη, +/- 10%. In one embodiment, the average particle size of the particulate filler is not less than 70μιη, 80μιη, 90 μιη, ΙΟΟμιη, 150μιη. In one example, the particulate filler has a particle size of between 60 and ΙΟΟμιη. In another example, the particulate filler has an average particle size of 90μιη, +/- 10%. In another embodiment, the average particle size of the particulate filler is not less than 700μιη, 750μιη, 800μιη, 850μιη, 900μιη. In one example, the particulate filler has a particle size of between 800 and 900 μm, preferably between 800 and 850 μm. In another example, the particulate filler has an average particle size of 850μιη, +/- 10%.

According to the invention, the particle size given corresponds to the particle size obtained with the Beckman Coulter LS 13320 particle size analyzer (Beckman Coulter, USA) using air as a solvent.

The inventors have demonstrated that spices, and more particularly spices in powder form, have the capacity to adsorb a large number of potentially malodorous VOCs in order to reduce the nauseating impression associated with their presence. Interestingly, these spices can also mask VOCs by the presence of their own VOCs, whose smell may take precedence over others.

Preferably, the particulate filler of the adsorbent layer of the device according to the invention comprises cinnamon powder, clove powder and / or turmeric, more preferably cinnamon. In a particular embodiment, the particulate filler of the adsorbent layer of the device according to the invention comprises cinnamon powder or turmeric powder having a particle size of between 40 and 100 μιη, 60 and ΙΟΟμιη, or 80 and 90μιη , +/- 10%. Advantageously, the particulate filler of the adsorbent layer of the device according to the invention comprises cinnamon powder having a particle size of between 50 and 60 μιη. In particular, the particulate filler of the cinnamon powder has an average particle size of 52 μπι, +/- 10%.

In a particular embodiment, the particulate filler of the adsorbent layer of the device according to the invention comprises clove powder having a particle size of between 10 and ΙΟΟΟμιη. In a particular embodiment, the clove powder has a particle size of between 800 and 900 μm, preferably between 800 and 850 μm, +/- 10%.

In one embodiment, the device comprises between 0.1 and 10 g of spices per 100 cm ² of material permeable to VOCs, preferably between 0.3 and 5 g, more preferably between 0.5 and 2 g, and between 0.5 and 0.5 g. and 1.5g, between 0.5 and 1g. For example, the device comprises between 0.5 and 1.5 g of cinnamon per 100 cm ² of material permeable to VOCs, and in particular about 0.9 g of cinnamon per 100 cm ² of material permeable to VOCs. In one embodiment, the device comprises between 0.1 and 2 g, preferably between 0.3 and 1.5 g, more preferably between 0.5 and 1 g of spices per 100 cm ² of material permeable to VOCs. In one embodiment, the device comprises between 1 and 4 g, preferably between 2 and 3 g, more preferably 2 g of spices, and in particular cinnamon, per 100 cm ² of material permeable to VOCs.

The VOC permeable material of the adsorbent layer may be any woven or nonwoven fabric. For example, the VOC permeable material of the adsorbent layer is nylon (poly (hexamethylene adipamide)), cotton, flax, viscose, polyethylene, polypropylene and / or polyester. Advantageously, the particulate filler is imbricated in and / or between the fibers of the woven or non-woven fabric.

In a particular embodiment, the material permeable to VOCs of the adsorbent layer is a textile having geometric shapes, such as a grid, cells, a matelasse, obtained in particular by stitching, welding, gluing, etc. textile or the fact of the weft of said textile. Advantageously, the shapes are distributed evenly over the entire surface of the textile and form compartments in the volume of which the particulate filler is retained independently of the site of use or gravity. In a particular embodiment, the textile is a honeycombed textile (such as a honeycomb textile). In another embodiment, the textile is a grid fabric. Thus, whatever the position of the adsorbent layer relative to the user, the particulate filler is maintained in the compartments and remains homogeneously distributed over the entire surface of the textile. More particularly, the use of such a compartmentalized textile makes it possible to prevent powder clusters from forming in a heterogeneous manner, in particular in the corners or in a part of the device during handling and / or in use. , especially because of gravity. The device according to the invention is particularly suitable for the adsorption of body odors, and in particular in the context of medical and paramedical uses, for adsorbing odors that may emanate from body fluids, such as exudates, urine, defecation, etc. The device according to the invention is particularly suitable for the adsorption of odors emanating from chronic wounds, and in particular tumor wounds from which emanate a very large number of malodorous VOCs, such as organosulfur compounds (such as DMDS dimethyl disulphide, DMTS dimethyltrisulfide), phenols and indoles. According to the invention, the device comprises an absorbent layer, intended to absorb the liquid or moisture may be present in the environment from which emanate odors. Thus, only the VOCs pass entirely or partially this first layer and will be able to be captured by the second adsorbent layer, the adsorbent properties are not disturbed by the presence of liquid. Any non-occlusive absorbent material may be used for this first layer. In one embodiment, the absorbent layer comprises at least one permeable or semi-permeable material, preferably chosen from alginates, viscose, carboxymethylcellulose (CMC), hydrophilic cotton or cellulose, hydrogels such as sodium polyacrylate, polyvinyl pyrrolidine, collagen, hyaluronic acid, chitosan, alginate, gelatin, and sponges or foam such as polyurethane foam or composites of these materials.

The device according to the invention may for example be a dressing, a layer, a hygienic protection, a compress or a panty liner. The absorbent layer is then intended to be in contact with the body fluid source to at least partially absorb the moisture. The device according to the invention may also be a dressing of the "secondary dressing" type intended to be affixed to a dressing itself in direct contact with the source of body fluid. In such an embodiment, the device according to the invention does not come into direct contact with the source of body fluid.

In one embodiment, the device further comprises a protective layer, preferably semi-permeable or impervious to moisture, arranged in such a way that it is sandwiched between the absorbent layer and the adsorbent layer. The protective layer makes it possible in particular to prevent the exudates back to the adsorbent layer, and conversely that the spices diffuse towards the absorbent layer, and that the adsorbent layer is contaminated by external liquids. Such a protective layer may in particular be a woven or non-woven fabric, a film or a microporous membrane. In a particular embodiment, the protective layer is composed of a material preferentially chosen from polyethylene, polypropylene, polyurethane, polyester, polyamide, polydimethylsiloxane, fluoropolymers and / or composites of these materials.

The invention relates to a dressing comprising a particulate filler based on cinnamon. The dressing comprises a first absorbent layer intended for example to be applied to a chronic wound, such as a tumor wound, and a second adsorbent layer consisting of a woven or non-woven fabric comprising cinnamon powder, preferably of particle size. between 80 and 90μιη, +/- 10%. Preferably, such a device comprises between 0.5 and 2 g, preferably between 1 and 1.5 g, of cinnamon per 100 cm ² of material permeable to VOCs.

The invention also relates to a dressing comprising a first absorbent layer intended for example to be applied to a chronic wound, such as a tumor wound, and a second adsorbent layer consisting of a woven or non-woven fabric comprising powder cinnamon, of particle size between 50 and 60 μιη, in particular equal to 52 μιη +/- 10%, said device comprising between 1 and 4g, and in particular about 2 g of cinnamon per 100 cm ² of material permeable to VOCs.

The invention also relates to a dressing comprising a particulate filler based clove. The dressing comprises a first absorbent layer intended, for example, to be applied to a chronic wound, such as a tumor wound, and a second adsorbent layer consisting of a woven or non-woven fabric comprising clove powder, of granulometry preferably between 10 and ΙΟΟΟμιη, and especially between 800 and 900 μιη, more preferably between 800 and 850μιη +/- 10%, for example about 820μιη. Preferably, such a device comprises between 0.5 and 2 g, or between 1 and 4 g, preferably between 1 and 1.5 g, or between 2 and 3 g of clove per 100 cm ² of material permeable to VOCs.

In a particular embodiment, the adsorbent layer comprises between 0.5 and 5 g, preferably between 1 and 4 g, more preferably 2 g of spices per 100 cm ² of material permeable to VOCs. The subject of the invention is also a dressing comprising a particulate filler based on turmeric, and in particular based on Curcuma longa. The dressing comprises a first absorbent layer intended, for example, to be applied to a chronic wound, such as a tumor wound, and a second adsorbent layer consisting of a woven or non-woven fabric comprising turmeric powder, preferably of particle size. between 50 and 150 μιη, preferably between 80 and ΙΟΟμιη, more preferably equal to 90μιη +/- 10%. Preferably, such a device comprises between 0.5 and 2 g, preferably between 1 and 1.5 g, of turmeric per 100 cm ² of VOC permeable material.

The subject of the invention is also a dressing comprising a particulate filler based on turmeric as described above, in which the particle size of the turmeric powder is between 50 and 150 μιη, preferably between 80 and ΙΟΟμιη, more preferably equal to at 90μιη +/- 10%, said device comprising between 1 and 4g, and in particular about 2 g of turmeric per 100 cm ² of material permeable to VOCs.

The inventors have indeed demonstrated that cinnamon, clove and turmeric are particularly effective in the case of tumor wounds, known as particularly smelly. More specifically, these spices, in powder form, have adsorbent properties comparable to those of activated charcoal (Actisorb®) on at least three VOCs characteristic of tumor wounds, namely DMDS, phenol and indole (FIGS. 1B, 1C). In addition, these spices have olfactory properties, including VOCs, which can hide VOCs that could persist and be a source of odorous odors. Such VOCs are absent in active charcoal-based devices (FIGS. 2A, 2B, 2C, 2D) making these spices more effective in solving problems related to bad odors.

According to the invention, the spice powder used is preferably capable of adsorbing at least 20%, 30%, 40%, preferably at least 50%, more preferably at least 60% of at least one of the three VOCs among the DMDS. , phenol and indole, and at least 20%, 30%, preferably at least 40% of the other two VOCs.

Alternatively, the spice powder is capable of adsorbing at least 20%, 30%, 40%, preferably at least 50% of the three VOCs, DMDS, phenol and indole. In one embodiment, the spice powder used is cinnamon powder capable of adsorbing at least 20%, 30%, 40%, preferably at least 50% of at least one of the three VOCs among the DMDS, the phenol and indole, and at least 20%, 30%, preferably at least 40% of the other two VOCs. In another embodiment, the spice powder used is cinnamon powder capable of adsorbing at least 65% of at least one of the three VOCs among DMDS, phenol and indole, and at least 75% of the other two VOCs.

In another embodiment, the spice powder used is cinnamon powder capable of adsorbing at least 20%, 30%, 40%, preferably at least 50% of the three VOCs: DMDS, phenol and indole .

In one embodiment, the particulate filler in the device according to the invention comprises or consists of Ceylon cinnamon (Cinnamomum verum or Cinnamomum zeylanicum), of the Lauraceae family. Such cinnamon is commercially available. It is also possible to use cinnamon from China {Cinnamomum aromaticum), cinnamon from Vietnam or Saigon (also called Cochinchine) (Cinnamomum loureiwi), cinnamon from Indonesia (Cinnamomum burmanniï) or cinnamon. from India (Cinnamomum tamala).

In a particular embodiment, the particulate filler in the device according to the invention comprises or consists of cinnamon powder releasing at least VOC (E) - cinnamaldehyde. In another particular embodiment, the cinnamon powder used as a particulate filler releases at least the VOC (E) -Cinnamaldehyde and at least one VOC among cc-copaene, γ-muurolene, cc-muurolene, cc-selinene, δ- cadinene, sativene, cc-bergamotene, D-germacrene, preferentially at least one VOC among cc-copaene, γ-muurolene, cc-muurolene and δ-cadinene. In a preferred embodiment, the cinnamon powder used as a particulate filler releases at least the VOCs (E) -cinnamaldehyde and γ-muurolene, cc-muurolene. In another preferred embodiment, the cinnamon powder used as particulate filler releases at least the (E) -cinnamaldehyde and cc-copaene VOCs. The presence of these VOCs can easily be verified by chromatography, in particular by gas chromatography. In a particular embodiment, the cinnamon powder used has a chromatographic profile similar to or identical to one of the profiles of FIG. 2B.

In a particular embodiment, the cinnamon powder used releases at least the VOCs (E) -cinnamaldehyde and cc-copaene, with a peak area obtained according to the method described in Example 1 greater than 100 × 10 ⁶ for (E). -cinnamaldehyde and / or greater than 30xl0 ⁶ for the cc-copaene, preferably a peak area greater than 200x10 ⁶ for (E) -cinnamaldehyde and / or a peak area greater than 60x10 ⁶ for Γ cc-copaene, even more preferably a peak area greater than 350x10 ⁶ for (E) -cinnamaldehyde and / or a peak area greater than 90x10 ⁶ for Γ cc-copaene. In a comparable manner, the subject of the invention is also a dressing comprising a particulate filler based on turmeric, and in particular Curcuma longa, from the family Zingiberaceae. Turmeric is a spice already used in the medical field, and especially in topical applications, for its anti-inflammatory action. The inventors have shown that powdered turmeric is also capable of adsorbing odors when it is used in a device comprising an absorbent layer intended to be in contact with the source from which malodours emanate and an adsorbent layer of which the particulate filler, which is not in direct contact with the source of unpleasant odors, includes turmeric powder.

In one embodiment, turmeric is turmeric longa. Such turmeric is commercially available. In a particular embodiment, the particulate filler in the device according to the invention comprises or consists of turmeric powder releasing at least the curcumene VOC or the VOC tumourone. Preferably, the turmeric powder used releases at least the curcumene and tumeric VOCs. The presence of these VOCs can easily be verified by chromatography, in particular by gas chromatography. In a particular embodiment, the turmeric powder used has a graphic chromato profile similar or identical to the profile of FIG. 2C.

In a comparable manner, the invention also relates to a dressing comprising a particulate clove based filler. In a particular embodiment, the particulate filler in the device according to the invention comprises or consists of clove powder releasing at least the VOC eugenol. The presence of this VOC can easily be verified by chromatography, in particular by gas chromatography. In a particular embodiment, the clove powder used has a chromatographic profile similar or identical to the profile of FIG. 2D.

The invention also relates to the use of cinnamon, turmeric or clove, as described above, more particularly in powder form, as an adsorbent in a device for the adsorption of odors, and especially body odor. Similarly, the invention relates to the use of an adsorbent layer comprising a material permeable to volatile organic compounds (VOCs) and a particulate adsorbent feed comprising at least cinnamon, turmeric or clove, as described herein. above, for the adsorption of odors, and in particular of body odors. Such uses are particularly interesting in the medical and paramedical field, particularly in a medical device such as a dressing. Similarly, the spice powder according to the invention can be used in surgical masks or anti-odor masks. Such masks can be directly designed from an adsorbent layer according to the invention, incorporating a spice powder such as cinnamon, turmeric or clove.

Examples

Example 1: Comparison of the adsorbent properties of activated charcoal (Actisorb®), cinnamon, turmeric and clove (powder).

In order to evaluate the adsorbent properties of cinnamon (Ceylon cinnamon - FV), turmeric (turmeric longa) and clove, the adsorption profiles on three VOCs characteristic of smelly necrosis, namely dimethyldisulphide (DMDS - C2H6S2), phenol (Ph - C _O H _O O) and indole (in - C8H7N) were studied in comparison with the profile of adsorption of activated carbon which is conventionally used to mask the odor from such necrosis.

In parallel, the adsorbent properties of three cinnamons from different sources (FV), (FC) and (FI) were compared by studying the adsorption profiles on these same three VOCs, in comparison with the activated carbon adsorption profile.

Material & Method

The composition of the test solution T3C, with the three VOCs characteristic of smelly necrosis, is as follows: pure water containing dimmethyl disulphide at 50 mg / l (DMDS), phenol at 125 mg / l (Ph) and indole at 500 mg / L (In). The pure compounds for the preparation of the solution come from Sigma-Aldrich (Saint-Quentin Fallavier, France).

The sample vials (round glass, internal diameter 22mm and height 75mm, hermetically closed with a screw cap with silicone seal) are prepared in the following way: in the bottom of the bottle a cellulose matrix (square 14mmxl4mm, 100mg) on which is deposited a volume of 20μί of the solution T3C (ie DMDS, 2 ^ g Ph and l (g In) which then soaks the cellulose matrix, then covered with a film of Aquacel® in polyurethane (1.8cm diameter, 40mg) and finally placing a square of cellulose (16mmx16mm, 130mg) containing between its frames 30mg of activated carbon (Actisorb®) or 30mg of cinnamon powder average particle size 75μιη, (1 (FV) / 2 (FC) / 3 (FI)) or 30mg of powdered turmeric of average particle size 90μιη (Curcuma longa) or 30mg of clove powder of average particle size 820μιη (Fyzygium aromaticum, or clove tree). witness, the reference, is also prepared in the same way but containing neither active arbon or spice.

The analysis method used couples a solid phase microextraction (SPME) in headspace mode (HS) managed by an automaton (sample changer arm), to a chromato-graphy in the gas phase (GC) with detection by single quadrupole mass spectrometry (MS). The SPME fiber used is a carboxenopolydimethylsiloxane (CAR-PDMS) fiber, length 10 mm and thickness 75 μm, from Supelco (Sigma-Aldrich, Saint-Quentin Fallavier, France).

The chromatograph and the mass spectrometer are models GC 7890A and 5975C XL MSD respectively from Agilent Technologies (Les Ulis, France). The automated sample changer coupled to the chromatograph is a Gerstel autosampler MPS (RIC, Saint-Priest, France).

Operating conditions: the flask is incubated for 6 min at 40 ° C. and the extraction in the head space of the flask is carried out for 30 min at 40 ° C. The desorption is done in the GC injector at 280 ° C in splitless mode for 10 min. The separation is carried out on a DB5-MS column containing a film of polydimethylsiloxane (methyl 95% -phenyl 5%), of dimension 30m × 0.25 mm with a film thickness of Ιμιη. The carrier gas is helium with a flow rate at the column outlet constant at 1.0 ml / min. The temperature program of the column is 40 ° C with holding 2 min, then at 7 ° C / min to 300 ° C and holding 1 min (analysis time 40.14 min). With regard to the spectrometric detection, the temperatures are: for the transfer line 280 ° C, the source 230 ° C and the quad 150 ° C. The ionization is done in electronic impact (El) under 70eV. Two detection modes implemented, the SCAN mode (progressive scan) between the m / z 25 to 300 and the SIM (Selected Ion Monitoring) mode for m / z 94 (targeted DMDS and Ph) and 117 (targeted In) . The compounds are identified by comparing experimental mass spectra (taken under the peak of chromatographic elution) with those of the National Institute of Standards and Technology Library (NIST, version 2.0f, rev.2010).

The elution peaks of the compounds on the chromatogram are characterized by: their retention time given in minute and taken at the maximum of the peak, as well as by their area (area under the peak envelope) given in arbitrary area units ( represents a number of strokes).

Results

As shown in Figure 1 and summarized in Table 1 below, the VOC adsorption rate by activated carbon (Actisorb®) is greater than 92%. Cinnamon has an adsorption rate of between 80 and 92% depending on the VOCs, confirming the adsorbent properties of the bad smells of this spice. Similarly the rates for adsorption are between 67 and 90% for clove and between 41 and 62% for turmeric.

In Tables 1 and 2, peak areas are given in area units. The control tube represents the reference in terms of quantities emitted in VOCs considered in the tube. The adsorption rate is calculated according to: adsorption rate = [(peak area COV control tube) - (peak area VOC tube with spice)] / (peak area COV control tube).

Table 1: Adsorption rate of dimethyldisulphide (DMDS), phenol (Ph) and indole (In) per 30 mg of activated charcoal (Actisorb®) or cinnamon (Ceylon cinnamon - FV) or turmeric or clove (in powder).

Witness: 3COVs; Actisorb®: 3COVs + 30mg activated carbon; cinnamon: 3COVs + 30mg cinnamon powder; Turmeric: 3COVs + 30mg turmeric powder; clove: 3COVs + 30mg clove powder

Table 2: Adsorption rate of dimethyldisulphide (DMDS), phenol (Ph) and indole (In) with 30 mg of activated carbon (Actisorb®) or different cinnamon powder (FV, FC and FI).

Time VOC Actisorb Control Cinnamon Cinnamon Cinnamon (fragment Area (x10 ⁶ ) Ceylon FC FI retention m / z for AU (x10 ⁶ ) (FV) Area VOC detection SIM)% Area (xlO ⁶ ) (xlO ⁶ )

(min) adsorbed (xlO ⁶ )%

adsorbed adsorbed adsorbed

10.00 DMDS 19.92 0.10 5.99 6.26 3.97

(m / z - 94) 99% 70% 80%

16.10 Ph 12.34 0.09 2.89 3.32

Example 2: Study of the VOCs present in cinnamon, turmeric and clove

As has been demonstrated above, the spice powders have a slightly lower adsorbent capacity than Actisorb® active charcoal vis-à-vis dimethyldisulphide, phenol and indole. However, on a panel of users, it is the devices according to the invention, comprising a particulate filler based on cinnamon, which have a higher satisfaction rate (see Example 3 below). In fact, fragrant spices have VOCs that can at least partially mask other VOCs, especially VOCs that may emanate from foul smelling wounds. The combination, according to the invention, of the adsorbent and odorous properties of the spice powders used makes it possible to potentiate the effects of the device and to give complete satisfaction to eliminate bad odors.

To determine which VOCs are present in cinnamon, turmeric and clove (powdered), which may mask odors, an analysis of VOCs of cinnamon (Ceylon cinnamon), turmeric (turmeric longa) clove (Fyzygium awmaticum, or clove) and activated charcoal (Actisorb®) were made. For this purpose, vials were prepared each directly comprising 30 mg of cinnamon (FV and FI), 30 mg of turmeric, 30 mg of clove powder or 30 mg of Actisorb®. Then the flasks were characterized with the same analytical method as that presented in Example 1 (rigorously identical operating conditions).

Results

As can be seen in Figure 2, and summarized in Table 3 below, the activated carbon does not release any VOC (Figure 2A). In contrast, cinnamon (Figure 2B), such as turmeric (Figure 2C) and clove (Figure 2D) release many VOCs. The masking aspect of fragrant spices, which allows spices not only to adsorb bad odors but also to cover them, can thus be explained by the presence of VOCs, totally absent from Actisorb®, some of which are likely to play strongly on sensory perception. This is the case for example (E) -cinnamaldehyde for cinnamon, curcumene and tumérone for turmeric or eugenol for clove. Table 3: Comparative Analysis of VOCs in Cinnamon (Ceylon Cinnamon - FV), Turmeric (Curcuma Longa), Clove and Activated Carbon (Actisorb®)

Time Name Formula Peak area if present

gross retention (CAS number) (in Area Unit xlO ⁶ )

(min) (Mass Actisorb® Cinnamon Turmeric Nail Molar - FV of g / mol) Clove

17.65 p-Cymene C10H14 no. 41 no

(99-87-6) (134)

17.78 D-Limonene CioHio No. 49 67 no

(5989-27-5) (136)

17,98 Eucalyptol CioHigO no. 30 no

(470-82-6) (154)

20,93 Camphor CIOHIÔO No. 37 61 no

(76-22-2) (152)

21.78 Methyl salicylate C ₈ H ₈ 0 ₃ No 128

(or Analgit) (152)

(119-36-8)

23.66 (E) -Cinnamaldehyde C ₉ H ₈ 0 no. 1660 no.

(14371-10-9) (132)

25.40 Eugenol C10H12O2 No. No 9059

(97-53-0) (164)

25,76 a-Copaene C15H24 No. 3384 No. 323

(3856-25-5) (204)

26,14 (E) -Isoeugenol C10H12O2 no. No. 98

(5932-68-3) (164)

26,29 (+) - Sativene C15H24 no 44 no no

(3650-28-0) (204)

26,60 a-Bergamotene C15H24 no 87 no no

(17699-05-7) (204)

26.83 Caryophyllene C15H24 No. 120 No. 4370

(87-44-5) (204)

26.85 D-germacrene C15H24 no 46 no no

(23986-74-5) (204)

27.40 a-Humulene C15H24 No. 205 No. 833

(or a- (204)

caryophyllene)

(6753-98-6)

27.43 CC-Curcumene C15H22 No. 862 No.

(644-30-4) (202)

27,57 γ-Muurolene C15H24 No. 437 No. 108

(30021-74-0) (204)

27,63 CC-Zingiberene C15H24 No. 162 no

(495-60-3) (204)

27,86 Aceteugenol Ci ₂ Hi ₄ 0 ₃ No. No 149

(93-28-7) (206) 27,89 -Himachalene C15H24 No. 124 No. (3853-83-6) (204)

27.96 α-Muurolene C15H24 No. 544 no.

(31983-22-9) (204)

28,05 β-selinene C15H24 # 41 no.

(17066-67-0) (204)

28.12 α-selinene C15H24 no 74 no no

(473-13-2) (204)

28,24 β-C15H24 no. 277 no

Sesquiphellandrene (204)

(20307-83-9)

28,28 δ-Cadinene C15H24 No. 908 No. 179

(483-76-1) (204)

28.45 (-) - Calamene C15H22 No. 646 No.

(483-77-2) (202)

28.62 Isolongifolene, C15H20 no 167 no no

4,5,9,10-dehydro (200)

(156747-45-4)

28.86 a-Calacorene C15H20 no 132 no no

(21391-99-1) (200)

29,64 Tumerone C15H22O No 82 no

(180315-67-7) (218)

30.38 Cubenol Ci ₅ H ₂₆ 0 no 45 no no

(21284-22-0) (222)

30.63a-Cadinol Ci ₅ H ₂₆ 0 no 48 no no

(481-34-5) (222)

30,70 β-Tumerone C15H22O No. 841 No.

(82508-14-3) (218)

30,78 AR- Tumerone C15H20O No. 167 No.

(532-65-0) (216)

31.13 Cadalene C15H18 no 37 no no

(483-78-3) (198)

31,37 CC-Tumerone C15H22O No. 225 no

(82508-15-4) (218)

no = not observed

Cinnamons of different origins (FV, FC, FI, W) were also analyzed to identify characteristic VOCs. Table 4: Comparative analysis of VOCs present in different cinnamon

nd = not detected

It is thus observed that these different cinnamons have a peak area for the (E) -namnamaldehyde greater than 350 × 10 ⁶ and / or a peak area for α-Copaene greater than 5 × 100 × 10 ⁶ .

Example 3: Sensory Perception

The adsorbent and masking properties of cinnamon (Ceylon Cinnamon - FV) and activated charcoal were evaluated and compared by blind testing on a panel of users on odors emitted by Maroille cheese. In parallel, the adsorbent and masking properties of different cinnamon (FV, FC, FI and W) were compared, also by blind tests on this panel of users on odors emitted by Maroille cheese.

Indeed, according to the analysis of JP Dumont (JP Dumont et al., Milk / January-February 1974 / No. 531-532, "Study of Neutral Volatile Compounds in Soft and Washed Crust Cheeses"). ), the smell of Maroille is very similar to that of tumor wounds. Table 3 below summarizes the main VOCs released by tumor wounds and by Maroille. The VOCs released by the tumor wounds were obtained by gas chromatographic analysis (analysis method identical to that of Example 1) three necrosis samples (necroses taken from malodorous tumor wounds).

Table 5: Main VOCs Common to Maroille and Tumor Wounds

Material & Method

The survey was conducted at the Institut Curie. The 16 participants in the survey are caregivers, doctors and researchers from the Curie Institute.

The main objective was to determine the best conditions or conditions to reduce the perception of smelly odors with cinnamon powder.

The evaluation of the hedonic nature of the samples was on a scale of 1 (very unpleasant) to 5 (very pleasant), the 3 being neutral. Perceived odors were also qualified by adjectives: "heavy / strong / sticky / aromatic / disgusting / disturbing / pleasant / sweet", and associated with adjectives such as "cadaveric / putrid / urinary / excremental / plant / pestilential" (multiple response possible).

Samples

The samples each included 6g of Maroille for 1g spice or Actisorb®. The Control, or witness, consisted of Maroille's 6g, alone.

These samples were placed in glass jars wrapped in foil for at least 20-30 minutes prior to testing, so that the specimens' odors disperse into the jar air and allow for effective sensory evaluation. Course of the study :

Participants were warned about the unpleasantness of the samples to avoid a surprise or hold effect, and thus maintain a constant inhalation.

The tests were done blind. Participants did not know the content of the samples. Samples were presented to each participant.

A "nose rinse" was systematically performed between two evaluations. The nose rinse was done by sniffing a jar containing water or his own skin (wrist or elbow).

The perception survey was conducted in kinetics to evaluate the effectiveness of compounds on smelly VOCs. The kinetic times were T0, T24 and T48 (in hours). The statistical analysis was carried out with the help of Prof. C. Dacremont, Center for Taste and Food Sciences, CNRS - INRA - University of Burgundy - AgroSup Dijon.

Results

The majority of participants considered odors from control samples (Maroille alone) and Actisorb® (Maroille + Actisorb®) samples to be unpleasant (2) to very unpleasant (1). Specifically, participants rate the control sample as 68% very unpleasant and the Actisorb® sample as unpleasant at 53% (Figures 3A and 3B).

Conversely, the majority of the participants considered the odors emanating from the samples containing the spices as neutral (3), pleasant (4) or very pleasant (5). In particular, 40% of participants associated the Cinnamon sample as pleasant, and 18% for turmeric. (Figures 3C, 3D and 3E).

The odors emanating from the samples containing the spices were mainly qualified as aromatic and pleasant. Conversely, odors emanating from control samples such as samples containing Actisorb® or control have been described as disgusting, disturbing and strong (Figure 4). Similarly, if a large number of participants associated odor from samples containing a spice to a "vegetable" or "greedy" odor, the qualifiers used for the odors emanating from the control sample and the sample containing the Actisorb ® are mainly "rotten" and "pestilential" (Figure 5). The sensory tests carried out with the different cinnamons all gave satisfaction (Figure 6). The majority of participants considered the smells from the samples containing cinnamon as neutral (3), pleasant (4) or very pleasant (5).

These sensory tests confirm that the spices used have a high adsorbent capacity and masking VOCs and especially VOCs perceived as unpleasant by users. Conversely, activated carbon is not able to adsorb and mask satisfactorily these same VOCs, which continue to be perceived as unpleasant and / or inconvenient by users.

Claims

An odor adsorption device comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice.

2. Device for adsorption of odors according to claim 1, wherein at least one spice is selected from cinnamon, turmeric and clove, preferably cinnamon.

3. Device for adsorption of odors according to claim 1 or 2, said device being able to adsorb body odors.

4. Device for adsorption of odors according to one of the preceding claims, wherein the particulate filler has a mean particle size less than ΙΟΟΟμιη, 900μιη, 800μπι, 700μπι, 600μπι, 500μπι, 400μπι, 300μηι, 200μπι, 150μπι, ΙΟΟμπι, 90μπι , 80 μπι, 70 μιη, 60 μιη, 50 μιη, 40 μιη. 5. Device for adsorption of odors according to one of the preceding claims, comprising between 00,

5 and 5 g, preferably between 1 and 4 g, more preferably 2 g of spices per 100 cm ² of material permeable to VOCs.

Odor adsorption device according to one of the preceding claims, wherein the VOC permeable material is a woven or non-woven fabric.

The odor adsorption device according to one of the preceding claims, wherein the VOC permeable material is nylon, cotton, flax, viscose, polyethylene, polypropylene or polyester.

An odor adsorption device according to any of the preceding claims, wherein the VOC permeable material has geometric shapes, and in particular a grid or cells, in which the particulate adsorbent filler is capable of being contained. .

An odor adsorption device according to any one of the preceding claims, wherein the absorbent layer comprises at least one permeable or semi-permeable material. permeable, preferentially chosen from alginates, carboxymethylcellulose (CMC), hydrophilic cotton and absorbent polymers, such as polyurethane foam.

An odor adsorption device according to any one of the preceding claims, further comprising a protective layer, preferably semi-permeable or impermeable to moisture, sandwiched between the absorbent layer and the adsorbent layer.

An odor adsorption device according to any one of the preceding claims comprising two absorbent layers and wherein the adsorbent layer is sandwiched between the two absorbent layers.

12. Device for the adsorption of odors according to one of claims 1-11, in the form of a dressing.

13. Device for the adsorption of odors according to one of claims 1-11, in the form of a layer, of hygienic protection, absorbent pad or pantiliner.