WO2018018775A1 - Procédé de surveillance de la profondeur du sommeil et instrument de surveillance de la profondeur du sommeil - Google Patents

Procédé de surveillance de la profondeur du sommeil et instrument de surveillance de la profondeur du sommeil Download PDF

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Publication number
WO2018018775A1
WO2018018775A1 PCT/CN2016/104620 CN2016104620W WO2018018775A1 WO 2018018775 A1 WO2018018775 A1 WO 2018018775A1 CN 2016104620 W CN2016104620 W CN 2016104620W WO 2018018775 A1 WO2018018775 A1 WO 2018018775A1
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WIPO (PCT)
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brain
sleep
region
detecting
depth
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PCT/CN2016/104620
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English (en)
Chinese (zh)
Inventor
李小平
夏茜
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纽沃凯生物科技（深圳）有限公司
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Publication of WO2018018775A1 publication Critical patent/WO2018018775A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4812—Detecting sleep stages or cycles

Definitions

  • the present invention provides methods and apparatus for measuring sleep depth.
  • the EEG can detect the state of the brain in the state of dozing and the state of non-sleeping of the brain, but can not distinguish the pattern of the brain in wake-up and the mode of sleep; electroencephalograph (EEG) and electro-oculogram (EOG) Combined with electromyography (EMG), it can detect the state of sleep in the brain, but no method or instrument can directly measure the depth of sleep.
  • EEG electroencephalograph
  • EOG electro-oculogram
  • the brain has multiple functional excitatory areas. Among them are the excitatory area, the sleep excitatory area, the thalamus and the blue spot nuclear excitatory area.
  • the driving excitement zone of the brain sends a driving electric signal or an action standby electric signal to each muscle of the whole body at any time.
  • the drive electrical signal or standby electrical signal first passes through the thalamus and is then driven through the excitation zone of the locus nucleus to the muscles of the body.
  • the excitement of the sleep excitement zone causes the sleep hormone to be released throughout the brain.
  • the results of sleep hormone release lead to: 1. The communication/contact of the whole brain's excitatory areas is blocked; 2.
  • the frequency of excitation of the blue nucleus excitatory area of the brain is reduced to zero, causing the brain to drive the excitatory area to the whole body muscles.
  • the emitted drive electrical signal or standby electrical signal is blocked in the excitation zone of the blue spot nucleus, weakened or not emitted at all.
  • the coordination of various brain neurotransmitters in the brain will cancel the obstruction of each excitatory area of the original brain. At this time, the brain is in a state of sleep.
  • the excitement of the excitation zone of the blue-spotted nucleus is reduced to a minimum/zero point.
  • the driving electrical signal or the standby electrical signal of the muscle-driven excitatory zone to the muscle cannot be emitted to the muscles of the body.
  • the present invention provides a method and apparatus for measuring the depth of sleep in a brain.
  • the measurement of the depth of sleep of the brain is achieved by detecting the degree to which the excitation region of the locus nucleus is suppressed.
  • a method for detecting the degree of inhibition of the excitation region of the locus nucleus to measure the depth of sleep of the brain is to detect the frequency or intensity of excitation of the excitation region of the locus coeruleus.
  • the detection method includes any method capable of detecting the frequency or intensity of excitation of the excitation region of the locus coeruleus, such as: electroencephalography (EEG, implanted or non-implanted), electromagnetic fluoroscopy, magnetoencephalography (MEG), Functional nuclear magnetic resonance (fMRI), positron emission tomography (PET).
  • another method for detecting the degree of inhibition of the excitation region of the locus nucleus to measure the depth of sleep of the brain is to measure the degree of decrease in the intensity of the electrical signal or the standby electrical signal emitted by the brain-driven excitation region of the driving nerve.
  • another method for detecting the degree of inhibition of the excitation region of the locus nucleus to measure the depth of sleep of the brain is to detect a driving electric signal or a standby electric signal emitted by the brain-driven excitatory region received by any muscle on the body.
  • the intensity of the drop as the depth of sleep decreases.
  • Figure 1 shows the interrelationship of the brain's four excitatory regions (driving excitatory regions, sleep excitatory regions, thalamus, and locus nucleus excitatory regions) in the awake mode associated with the present invention.
  • Figure 2 shows the interrelationship of the brain's four excitatory regions (driving excitatory regions, sleep excitatory regions, thalamus, and locus nucleus excitatory regions) in the transition from awakened mode to sleep mode.
  • Fig. 3 shows the degree of inhibition of the brain by measuring the degree of inhibition of the excitation region of the locus coerule by directly inserting the electrode needle into the excitation region of the locus coeruleus.
  • Fig. 4 shows the degree of sleep of the brain measured by detecting the change in potential on the scalp with the electroencephalograph of the present invention to detect the degree of inhibition of the excitation region of the locus nucleus.
  • Fig. 5 shows the degree of sleep of the brain measured by detecting the change in the excitation frequency of the excitation region of the locus coeruleus with electromagnetic waves to detect the degree of inhibition of the excitation region of the locus coeruleus.
  • Figure 6 shows the use of the electrode needle insertion drive nerve detection of the present invention to measure the sleep of the brain by detecting the change in the driving electrical signal or the standby electrical signal intensity emitted by the brain-driven excitation zone of the driving nerve to detect the suppressed area of the locus nuclear nucleus. depth.
  • Fig. 7 is a view showing the change of potential of the skin near the driving nerve by the electroencephalograph of the present invention to detect the change of the driving electric signal or the standby electric signal intensity emitted by the brain driving excitatory region of the driving nerve to detect the suppression of the excitation region of the locus nucleus The degree to measure the depth of sleep in the brain.
  • Fig. 8 is a view showing the measurement of the sleep depth of the brain by detecting the change in the driving electric signal or the standby electric signal intensity emitted by the brain-driven excitation region of the driving nerve by the electromagnetic wave of the present invention to detect the suppressed degree of the excitation region of the locus nucleus.
  • Figure 9 is a view showing the change of the intensity of the driving electric signal or the standby electric signal emitted by the brain-driven excitatory region received by the muscle by the electrode needle of the present invention to detect the stimuli of the locus nucleus.
  • the degree of inhibition measures the depth of sleep in the brain.
  • Figure 10 is a diagram showing the change of the intensity of a driving electric signal or a standby electric signal emitted by a brain-driven excitatory region received by the electrode on the skin surface of any muscle of the body of the present invention to detect the excitation region of the locus nucleus. The degree of inhibition is measured to measure the depth of sleep of the brain.
  • Figure 11 is a diagram showing changes in the intensity of a driving electric signal or a standby electric signal emitted by a brain-driven excitatory region received by the muscle of the muscle of the skin of the body using two or more electrodes of the present invention to detect blue.
  • the degree of inhibition of the nucleus excitatory region is measured to measure the depth of sleep of the brain.
  • Figure 12 is a graph showing the change in the intensity of a driving electric signal or a standby electric signal emitted by a brain-driven excitatory region received by any one of the muscles of the present invention by electromagnetic waves to detect the degree of suppression of the excitation region of the locus nucleus. The depth of sleep in the brain.
  • Figure 13 is a view showing the change of the intensity of the driving electric signal or the standby electric signal emitted by the brain-driven excitation zone received by any muscle on the limbs of the present invention as shown in Figure 11 to detect the excitation region of the locus coeruleus. The degree of inhibition is measured to measure the depth of sleep of the brain.
  • Figure 14 is a diagram showing changes in the intensity of a driving electric signal or a standby electric signal emitted by a brain-driven excitatory region received by any muscle on the face of the present invention as shown in Figure 11 to detect the excitation region of the locus nucleus. The degree of inhibition is measured to measure the depth of sleep of the brain.
  • Figure 15 is a diagram showing the change of the intensity of an electrical signal or a standby electrical signal emitted by a brain-driven excitatory region received by any of the muscles on the finger or toe of the method of Figure 11 of the present invention to detect the excitation region of the locus nucleus The degree of inhibition is measured to measure the depth of sleep of the brain.
  • the driving excitation zone 2 drives the electric signal or the standby electrical signal 5 first through the thalamus 3, then through the blue plaque excitatory zone 4, and then through the driving nerve 6, and sends it to the body. Any piece of muscle 8 .
  • the sleep excitement zone 7 increases the excitement, releases the sleep hormone through the channel 9, suppresses the excitation of the blue spot nuclear excitatory zone 4, and blocks the driving electric signal or the standby electric power.
  • the signal 5 passes through the lobe nucleus excitation zone 4 until the drive electrical signal or standby electrical signal 5 in the drive nerve 6 diminishes or tends to zero.
  • the depth of sleep of the brain refers to a measure of the degree to which the brain transitions from the awake mode to the deep sleep mode, and the measure of the depth of sleep of the brain is expressed by the percentage reduction of the excitation region of the nucleus nucleus and thereby reducing the excitability, for example,
  • the depth of sleep is divided into 0 to 10 levels.
  • the degree of inhibition of the excitation region of the locus coeruleus is zero (0%).
  • the degree of inhibition is 50% (0%)
  • the degree of inhibition of the locus nuclear nucleus is 100% (100%).
  • Fig. 3 shows a method and system for detecting the extent to which the excitation of the locus nucleus excitatory region 4 in the brain 1 is shifted from the awake mode to the deep sleep mode to measure the depth of sleep.
  • a system for detecting a change in the excitation intensity of the excitation region of the locus nucleus nucleus 4 is mainly composed of the electrode needle 10 and the signal processing system 11 to measure the degree of depression of the excitation region 4 of the locus coeruleus to measure the depth of sleep of the brain 1.
  • the electrode needle 10 is inserted into the locus nucleus excitation zone 4, and the change in the excitation frequency of the locus nucleus excitation zone 4 is directly detected, and then the sleep depth of the brain 1 is directly read by the signal processing system 11.
  • Figure 4 shows another method and system for detecting the extent of excitability in the process of detecting the depth of sleep in the process of brain 1 transitioning from a awake mode to a deep sleep mode.
  • a system for detecting a change in potential on the scalp 14 mainly composed of the electrode 12 and the signal processing system 13 measures the depth of sleep of the brain 1 by detecting the degree of suppression of the excitation region 4 of the nucleus.
  • the electrode 12 is attached to the scalp 14, the potential change on the scalp 14 is detected, and the sleep depth of the brain 1 is directly read by the signal processing system 13.
  • Fig. 5 shows another method and system for detecting the extent to which the excitation of the locus nucleus excitatory region 4 is suppressed in the course of the brain 1 transitioning from the awake state to the sleeping state to measure the depth of sleep.
  • a system mainly composed of an electromagnetic wave signal transmitting and processing system 15, a transmitting antenna 16, and a receiving antenna 17 for oscillating the excitation frequency of the excitation region 4 of the blue-spotted nucleus with electromagnetic waves to detect the degree of suppression of the excitation region 4 of the nucleus To measure the depth of sleep of brain 1.
  • the electromagnetic wave signal transmitting and processing system 15 emits electromagnetic waves through the transmitting antenna 16, then passes through the blue-spotted nuclear excitation region 4 of the brain 1, and finally receives and returns the electromagnetic wave signal transmitting and processing system 15 by the receiving antenna 17, and the electromagnetic wave signal is emitted.
  • the processing system 15 compares the received signal with the emitted signal, and detects the degree of suppression of the locus nucleus excitatory region 4 by detecting the change in the excitation frequency of the locus nucleus excitation region 4 to measure the sleep depth of the brain 1.
  • Fig. 6 shows another method and system for detecting the degree of sleep deprivation in the process of detecting the degree of excitability in which the locus nucleus excitatory region 4 is shifted from the awake state to the sleeping state.
  • a system consisting of the electrode needle 18 and the signal processing system 19 detects the change in the intensity of the driving electrical signal or the standby electrical signal 5 emitted by the brain driving the excitation zone 2 of the driving nerve 6 to detect the excitation region of the blue spot nucleus
  • the degree of inhibition is measured to measure the depth of sleep of the brain.
  • the electrode needle 18 is inserted into the driving nerve 6, and the change in the intensity of the driving electric signal or the standby electric signal 5 emitted from the brain driving excitatory region 2 of the driving nerve 6 is detected, and the brain is directly read by the signal processing system 19. 1 sleep depth.
  • Fig. 7 shows another method and system for detecting the extent to which the excitation of the locus nucleus excitatory region 4 in the brain 1 is shifted from the awake mode to the deep sleep mode to measure the depth of sleep.
  • the potential change of the skin surface 22 in the vicinity of the driving nerve 6 is mainly composed of the electrode 20 and the signal processing system 21 to detect the intensity of the driving electric signal or the standby electric signal 5 emitted by the brain driving excitation region 2 of the driving nerve 6.
  • the varying system measures the depth of sleep of brain 1 by detecting the degree of inhibition of the excitation region 4 of the locus coeruleus.
  • the electrode 20 is attached to the skin surface 22 near the drive nerve 6, and the change in potential on the skin surface 22 near the drive nerve 6 is detected, and the sleep depth of the brain 1 is directly read by the signal processing system 21.
  • Figure 8 is a diagram showing another method and system for detecting the depth of sleep in the process of detecting the depth of excitability of the locus nucleus excitatory region 4 during the transition of the brain 1 from the awake mode to the deep sleep mode.
  • a system mainly composed of an electromagnetic wave signal transmitting and processing system 23, a transmitting antenna 24, and a receiving antenna 25, which detects a change in the intensity of a driving electric signal or a standby electric signal 5 emitted from a brain driving excitatory region 2 of a driving nerve 6 by electromagnetic waves.
  • the depth of sleep of the brain 1 was measured by detecting the degree of inhibition of the excitation region 4 of the locus coeruleus.
  • the electromagnetic wave signal transmitting and processing system 23 transmits electromagnetic waves through the transmitting antenna 24 through the driving nerve 6, and is then received by the receiving antenna 25 and transmitted back to the electromagnetic wave signal transmitting and processing system 23.
  • the electromagnetic wave signal transmitting and processing system 23 compares the received signal with the emitted signal to detect the change in the intensity of the driving electric signal or the standby electric signal 5 emitted by the brain driving excitation zone 2 of the driving nerve 6, thereby detecting the excitation of the blue spot nucleus.
  • the degree of inhibition of zone 4 measures the depth of sleep of brain 1.
  • Fig. 9 shows another method and system for detecting the degree of sleep deprivation in the process of detecting the degree of excitability of the locus nucleus excitatory region 4 in the process of the brain 1 transitioning from the awake mode to the deep sleep mode.
  • a system consisting of the electrode needle 26 and the signal processing system 27 detects the change in the intensity of the driving electric signal or the standby electric signal 5 emitted by the brain driving excitation zone 2 received by any muscle 8 of the body to detect The degree of inhibition of the locus nucleus excitatory region 4 was measured to measure the depth of sleep of the brain 1.
  • the electrode needle 26 is inserted into any muscle 8 of the body, and the change in the intensity of the driving electric signal or the standby electric signal 5 emitted by the brain driving excitatory region 2 received by the muscle 8 is detected, and then passed through the signal processing system 27. To directly read the sleep depth of the brain 1.
  • Fig. 10 is a view showing another method and system for detecting the degree of sleep in the process of detecting the extent to which the excitation of the locus nucleus excitatory region 4 in the brain 1 is shifted from the awake mode to the deep sleep mode.
  • the electrode 28 and the signal processing system 29 are mainly used to detect the potential change of the skin surface 30 on any muscle 8 of the body to detect the driving electric signal or the standby electric signal emitted by the brain driving excitation zone 2 received by the muscle 8.
  • a system of changes in the intensity of 5 to detect the degree of inhibition of the excitation region 4 of the locus coeruleus to measure the depth of sleep of the brain 1.
  • the electrode 28 is attached to the skin surface 30 on any muscle 8 of the body, and the intensity of the potential change on the skin surface 30 on any muscle 8 of the body is detected as the brain drives the excitatory area received by the muscle 8.
  • the change in the intensity of the drive electric signal or the standby electric signal 5 that is emitted is further read by the signal processing system 29 to directly read the sleep depth of the brain 1.
  • Figure 11 shows another method and system for detecting the extent of excitability in the process of detecting the depth of sleep in the process of brain 1 transitioning from the awake mode to the deep sleep mode.
  • a change in the potential difference of the skin surface 30 on any of the muscles 8 of the body is mainly composed of two or more electrodes 31 and a signal processing system 32 to detect the brain-driven excitation zone 2 received by the muscle 8
  • two or more electrodes 31 are attached to the skin surface 30 on any muscle 8 of the body, and the intensity of the change in potential difference on the skin surface 30 on the muscle 8 is detected as the muscle receives the brain 8
  • the change in the intensity of the drive electrical signal or the standby electrical signal 5 emitted by the excitation zone 2 is driven, and the sleep depth of the brain 1 is directly read by the signal processing system 32.
  • Figure 12 is a diagram showing another method and system for detecting the depth of sleep in the process of detecting the depth of excitability of the locus nucleus excitatory region 4 during the transition of the brain 1 from the awake mode to the deep sleep mode.
  • the electromagnetic wave signal transmitting and processing system 33, the transmitting antenna 34 and the receiving antenna 35 are used to detect the driving electric signal or the standby electric signal 5 emitted by the brain driving excitation zone 2 received by any muscle 8 of the body.
  • the electromagnetic wave signal transmitting and processing system 33 transmits electromagnetic waves through the transmitting antenna 34 through any muscle 8 of the body, and is then received by the receiving antenna 35 and transmitted back to the electromagnetic wave signal transmitting and processing system 33.
  • the electromagnetic wave signal transmitting and processing system 33 compares the received signal with the emitted signal to detect a change in the intensity of the driving electric signal or the standby electric signal 5 emitted by the brain driving excitatory region 2 received by the muscle 8 to detect the blue spot.
  • the degree of inhibition of the nuclear excitation zone 4 thus measures the depth of sleep of the brain 1.
  • Figure 13 is a view showing another method and system for detecting the depth of sleep in the process of detecting the depth of sleep in the process of the brain 1 transitioning from the awake mode to the deep sleep mode in the brain 1 from the awake mode to the sleep mode, mainly by the strap 36, in the strap
  • the upper circuit board 37 (which may include: two or more electrodes 39, the signal acquisition circuit 40, the signal storage module 41, the signal transmission module 42, the system control module 43, the battery 44), and the locking mechanism 38 on the belt
  • Figure 14 is a view showing another method and system for detecting the depth of sleep in the process of detecting the depth of sleep in the process of the brain 1 transitioning from the awake mode to the deep sleep mode in the brain 1 from the awake mode to the sleep mode, mainly by patch 45, skin
  • the adhesive layer 61, the circuit board 46 on the patch (which may include: two or more electrodes 47, the signal acquisition circuit 48, the signal storage module 49, the signal transmission module 50, the system control module 51, the battery 52)
  • Figure 15 is a view showing another method and system for detecting the depth of sleep in the process of detecting the depth of sleep in the process of the brain 1 undergoing the transition from the awake state to the deep sleep state of the locus nucleus excitatory region 4, mainly by the finger ring 53, in the ring
  • the upper circuit board 54 (which may include: two or more electrodes 55, signal acquisition circuit 56, signal storage module 57, signal transmission module 58, system control module 59, battery 60) is formed by detecting any muscle on the finger
  • the system in which the brain drives the change in the intensity of the driving electric signal or the standby electric signal 5 emitted from the excitation zone 2 measures the degree of depression of the brain 1 nuclear excitation zone 4 to measure the sleep depth of the brain 1.

Abstract

L'invention concerne un procédé et un instrument permettant de mesurer la profondeur de sommeil du cerveau. La mesure de la profondeur de sommeil du cerveau est réalisée par détection du degré inhibé de la région d'excitation du locus coeruleus dans le processus selon lequel le cerveau est converti d'un état d'éveil à un état de sommeil. Le procédé de mesure consiste à : 1. détecter directement le degré inhibé de la région d'excitation du locus coeruleus ; 2. détecter le degré inhibé de la région d'excitation du locus coeruleus par détection de la réduction de l'intensité d'un signal électrique de commande ou d'un signal électrique de secours envoyé par une région d'excitation du nerf moteur entraînée par le cerveau ; 3. détecter le degré inhibé de la région d'excitation du locus coeruleus par détection de la réduction d'intensité du signal électrique ou du signal électrique de secours envoyé par la région d'excitation entraînée par le cerveau reçue par tout muscle du corps.
PCT/CN2016/104620 2016-07-26 2016-11-04 Procédé de surveillance de la profondeur du sommeil et instrument de surveillance de la profondeur du sommeil WO2018018775A1 (fr)

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CN201610594910.6A CN107647847A (zh) 2016-07-26 2016-07-26 睡眠深度监测方法和睡眠深度监测仪
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PCT/CN2016/104565 WO2017076324A1 (fr) 2015-11-04 2016-11-04 Procédé et système destinés à favoriser l'abstinence mettant en oeuvre un champ électromagnétique de manière à moduler la région du cerveau chargée de l'excitation
PCT/CN2016/104620 WO2018018775A1 (fr) 2016-07-26 2016-11-04 Procédé de surveillance de la profondeur du sommeil et instrument de surveillance de la profondeur du sommeil

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