WO2018016819A1 - Rf energy transmitter and rf energy transmission method - Google Patents

Rf energy transmitter and rf energy transmission method Download PDF

Info

Publication number
WO2018016819A1
WO2018016819A1 PCT/KR2017/007646 KR2017007646W WO2018016819A1 WO 2018016819 A1 WO2018016819 A1 WO 2018016819A1 KR 2017007646 W KR2017007646 W KR 2017007646W WO 2018016819 A1 WO2018016819 A1 WO 2018016819A1
Authority
WO
WIPO (PCT)
Prior art keywords
temperature
energy
temperature rise
section
rise section
Prior art date
Application number
PCT/KR2017/007646
Other languages
French (fr)
Korean (ko)
Inventor
고광천
Original Assignee
주식회사 루트로닉
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 루트로닉 filed Critical 주식회사 루트로닉
Publication of WO2018016819A1 publication Critical patent/WO2018016819A1/en

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/06Electrodes for high-frequency therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/08Arrangements or circuits for monitoring, protecting, controlling or indicating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/00458Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
    • A61B2018/00464Subcutaneous fat, e.g. liposuction, lipolysis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00589Coagulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00696Controlled or regulated parameters
    • A61B2018/00714Temperature

Definitions

  • the present invention relates to an RF energy delivery device and an RF energy delivery method, and more particularly, to an RF energy delivery device and an RF energy delivery method for delivering heat by heating RF energy and treating cells.
  • Subcutaneous fat is formed by the accumulation of fat cells distributed in the subcutaneous layer, and subcutaneous fat has a much larger volume than normal cells when mature, and contains 95% of fat. These adipocytes contain less water than other cells and can be heated to higher temperatures than other cells when RF energy is delivered.
  • the present invention is to solve the problem that takes a long time when heating the cell by transmitting the conventional RF energy, to provide an RF energy delivery device and RF energy delivery method for preventing skin damage caused during excessive RF transmission. have.
  • RF generator configured to generate RF energy
  • an applicator including an electrode configured to deliver RF energy to an object located in the body, and a plurality of temperature rise sections when RF energy is delivered to the object to reach a treatment temperature
  • An RF energy transmission device including a control unit for differently controlling the magnitude of the RF energy transmitted for each temperature rise section is provided.
  • the plurality of temperature rise sections include a first temperature rise section for rapidly increasing the temperature of the object to a reference temperature adjacent to the treatment temperature and a second temperature rise section for increasing the temperature of the object from the reference temperature to the treatment temperature.
  • a first temperature rise section for rapidly increasing the temperature of the object to a reference temperature adjacent to the treatment temperature
  • a second temperature rise section for increasing the temperature of the object from the reference temperature to the treatment temperature.
  • first RF energy delivered during the first temperature rise section may be greater than the second RF energy delivered during the second temperature rise section to rapidly increase the temperature of the object.
  • the plurality of temperature rising sections may further include a temperature holding section in which the subject maintains the treatment temperature for a predetermined time after the second temperature rising section, and the first and second temperature rising sections are transferred to the temperature holding section.
  • Third RF energy smaller than the second RF energy may be delivered.
  • first temperature rise section may last longer than the second temperature rise section so that the subject can quickly reach the treatment temperature.
  • the duration of the second temperature rise section may be 50% to 100% of the first temperature rise section, and the duration of the temperature maintenance section may be 50% to 200% of the first temperature rise section.
  • the applicator further includes a temperature sensor configured to measure the surface temperature of the skin and a cooling unit configured to cool the surface of the skin, and the control unit drives the cooling unit when the surface temperature becomes higher than the required cooling temperature. Can be controlled.
  • the cooling required temperature may be 48 °C to 50 °C to prevent damage to the skin in the temperature rise section.
  • the cooling unit may be configured to be air cooled to prevent the surface temperature from being rapidly cooled.
  • the controller may be driven for a time within 5 minutes in one drive so that the temperature of the target object does not fall when the cooling unit is driven.
  • the controller may control the size of the first RF energy to be 3 to 5 times the size of the third RF energy so that the subject can quickly reach the reference temperature in the first temperature rise section.
  • the first RF energy may be 300W to 500W
  • the second RF energy may be 100W to 300W
  • the third RF energy may be 50W to 150W.
  • the first temperature rise section may last 5 minutes to 15 minutes
  • the second temperature rise section may last 5 minutes to 10 minutes
  • the temperature maintenance section may last 5 minutes to 15 minutes.
  • the subject includes adipose cells
  • the treatment temperature is a temperature at which the fat cells are denatured
  • a temperature at which the fat cells are denatured may be 44 ° C. to 46 ° C.
  • the reference temperature may be 40 °C to 44 °C.
  • the controller may control the first RF energy and the second RF energy so that the object can be heated to the largest temperature rise rate during the first temperature rise period.
  • the reference temperature may be lower than the treatment temperature.
  • a cooling step of cooling the skin may be performed when the surface temperature of the skin adjacent to the object corresponds to the required cooling temperature.
  • the duration of the second temperature rise section may be 50% to 100% of the first temperature rise section, and the duration of the temperature maintenance section may be 80% to 200% of the first temperature rise section.
  • the RF energy delivery device and the RF energy delivery method according to the present invention can be heated to a treatment temperature quickly, so that the overall time required can be shortened, and excessive energy can be prevented, thereby increasing stability.
  • FIG. 1 is a perspective view of an adipocyte treatment apparatus according to the present invention.
  • FIG. 2 is a conceptual diagram of a fat cell treatment apparatus.
  • 3 is a state diagram used in the treatment of fat cells.
  • 5 is a graph of RF output.
  • Figure 7 is a flow chart of the RF energy delivery method for adipocyte treatment.
  • RF energy can be applied to various devices for carrying out treatment by delivering RF energy to the treatment site.
  • 'treatment' refers to treatment by changing the lesion site including degeneration and removal of tissues such as COAGULATION and ABULATION of cells for tissue regeneration.
  • FIGS. 1 to 6 With respect to the adipocyte treatment apparatus of an embodiment of the present invention.
  • Body portion 100 is provided with a user interface for configuration and control for generating RF energy, is configured to generate RF energy in connection with an external power source. It also includes components that perform overall control of the device, including control of size and time of RF energy.
  • the applicator 300 is disposed adjacent to the body and is configured to deliver RF energy into the body.
  • the applicator 300 may include an applicator body 310, an antenna 320, a temperature sensor 330, a cooling unit 340, and a guide unit 350.
  • the link 200 is configured to mechanically connect the body part 100 and the applicator 300 to fix the applicator 300.
  • the link 200 may be configured to include a plurality of joints so that the applicator 300 may be disposed at various positions.
  • FIG. 2 is a conceptual diagram of a fat cell treatment apparatus.
  • the body portion 100 is configured to include a power supply 110, an RF circuit, a user interface (not shown), a data storage unit 170 and the control unit 140, the applicator 300 is It is configured to include an antenna 320, a temperature sensor 330, a cooling fan (not shown) and the guide unit 350.
  • the power supply unit 110 is connected to an external power source and is connected to other electrical components including the RF circuit, the interface unit 160, and the controller 140.
  • the RF circuit is configured to modulate the energy delivered from the power supply 110 into RF and deliver it to the applicator 300.
  • the RF circuit may include an RF generator 120, a balloon circuit 130, and primary and secondary transformers (not shown). Although not shown, the RF circuit may include ancillary components for performing modulation, balance, matching, and the like.
  • the RF generator 120 is configured to modulate the delivered energy into Radio Frequancy (RF).
  • the RF generator 430 according to the present embodiment is configured to generate RF energy having a frequency of 27.12 MHz.
  • the RF generator 430 corresponds to a frequency of an ISM band such as 13.553 to 13.567 MHz, 26.975 to 27.283 MHz, and 40.66 to 40.70 MHz.
  • the balun circuit 130 may modulate an unbalanced impedance into a balanced impedance when transmitting RF energy.
  • the primary and secondary transformers perform impedance matching. On the other hand, since the configuration of such an electrical component is generally used configuration, detailed description of the detailed configuration will be omitted.
  • the interface unit 160 is configured to notify a user of an operation input, a current state, and the like.
  • the interface unit 160 may include an image output unit (not shown) and an audio output unit (not shown).
  • the image output unit and the audio output unit may be provided on an outer surface of the body unit 100.
  • the data storage unit 170 may store various information necessary for operating the device, and may store information about protocols and algorithms for controlling RF energy in response to a current state of the patient's body impedance.
  • the controller 140 is configured to perform control of components including input, output, and RF circuits.
  • the controller 140 may be connected to each electrical component to perform signal processing, and control may be performed according to an algorithm stored in the data storage unit 170.
  • the temperature sensor 330 and the cooling fan provided in the applicator 300 is configured to adjust the output of the cooling fan according to the sensing value. Meanwhile, the RF energy control of the controller 140 will be described in detail later.
  • the applicator 300 is configured to be disposed adjacent to the patient as described above to apply RF energy to the human body.
  • the applicator 300 includes an applicator body 310, an antenna 320, a temperature sensor 330, a cooling fan (not shown), and a guide unit 350.
  • the applicator body 310 may be configured in a size corresponding to the average width of the abdomen to apply RF energy to a large area of the patient's body.
  • the applicator body 310 may be provided with an antenna 320, a temperature sensor 330, and a cooling unit 340 therein.
  • the applicator body 310 may be disposed at an appropriate distance from the skin (S) so that the RF energy can be efficiently transmitted to the subcutaneous fat layer during operation.
  • the cooling unit 340 may be configured to include a tube to receive the air from the body portion 100, the cooling wind provides a cold strong wind to the skin through a plurality of holes formed in the applicator body 310 can do.
  • the configuration of the cooling unit described above is just an example, and may be configured as a fan (not shown) provided in the applicator body 310.
  • the guide unit 350 is configured not to be separated from the portion where the applicator body 310 is disposed when the device is operated, and is connected to the applicator body 310 to guide the applicator 300 according to the body curvature of the patient. It can be configured to be rotatable.
  • 3 is a state diagram used in the treatment of fat cells.
  • treatment proceeds in a manner that delivers RF energy to the patient's subject Vt with two antennas 320 spaced apart at the treatment location.
  • Treatment is aimed at reducing the subcutaneous fat of the subject (Vt).
  • the control unit 140 transmits the RF energy to the treatment position through the antenna 230
  • the plurality of components are controlled to increase the temperature of the subcutaneous fat to the treatment temperature and to be maintained for a predetermined time.
  • the treatment temperature can be 45 degrees to 50 degrees Celsius.
  • a pair of electrodes has been described as an example, one pair of inductive electrodes and a plurality of capacitive electrodes may be configured to deliver RF energy.
  • FIG. 4 is a graph of a temperature (Tfat) of the target object (Vt) during RF energy transfer
  • FIG. 5 is a graph of RF energy
  • FIG. 6 is a diagram showing a state of use during cooling.
  • the temperature of each part of the body tissue including subcutaneous fat is increased during RF energy delivery. Specifically, the temperature Tfat of the target object Vt and the surface temperature Tskin of the skin S adjacent thereto are shown with time.
  • the transfer of RF energy may be divided into an energy transfer step into a first temperature rise section P1, a second temperature rise section P2, and a temperature maintenance section P3 according to the magnitude of energy delivered by the controller 140.
  • the cooling step (Pc) may be performed by dividing.
  • the first temperature rise section P1 is a step of delivering the largest first RF energy to rapidly reach the target temperature T1 in which the fat cells are distributed, to the reference temperature T1.
  • the fat layer is less heat transfer by the blood or surface than the skin or muscle, so absorbed energy is not easily released. Therefore, the larger the transmitted RF energy, the faster the temperature Tfat of the target object Vt rises. Therefore, the first temperature rise rate is shown in the first temperature rise section (P1) by transferring the RF energy with the largest power, the object temperature (Vt) is the fastest temperature of the entire section.
  • the rate of temperature rise of fat layer, skin (S) and muscle is different when delivering RF energy within a certain size.
  • the temperature of the fat layer is less heat than other tissues, but in the case of muscles, it has a cooling effect by blood, and the skin (S) has a lower temperature than fat volume due to heat loss cooling by air on the surface.
  • the temperature reversal occurs when the surface temperature is higher than the fat layer.
  • the first RF energy RF1 large enough to cause such a temperature reversal may be transferred to heat the object Vt.
  • the surface temperature (Tskin) of the skin (S) can be raised rapidly, even if the natural cooling by the air on the surface is constantly rising the temperature.
  • the cooling step (Pc) may be performed to prevent this. This will be described later.
  • the first RF energy RF1 transmitted from the first temperature rise section P1 may be transmitted at a power of 300 W to 500 W, and in this case, to prevent the temperature Tfat of the object Vt from excessively rising. In order to be carried out within 5 to 15 minutes.
  • the first temperature increase section P1 is terminated when the temperature Tfat of the target object Vt corresponds to the reference temperature T1 and is of a different size so as to enter the second temperature rise section P2 which is the next step. RF energy can be delivered.
  • the second temperature rise section P2 corresponds to a step for stabilizing the heat distribution of the target object Vt.
  • the second temperature rise section P2 Transmits the second RF energy RF2 smaller than the first RF energy RF1 so that the region where the temperature deviation occurs has a uniform temperature distribution as a whole by heat exchange with the surroundings.
  • the size of the second RF energy RF2 is determined as a size at which the temperature may rise at a second temperature rise rate at which the temperature Tfat of the target object Vt is smaller than the first temperature rise rate.
  • the second temperature rise section P2 is the second RF energy (RF2) is delivered at a power of 100W to 300W, the duration may be made of about 5 to 10 minutes.
  • the energy is transferred to the skin (S) during the second RF energy (RF2) transfer, so that the temperature can rise, even in this case, if the surface temperature (Tskin) of the skin rises to the required cooling temperature (T3) cooling step
  • the controller functions to perform (Pc).
  • the temperature of the skin S is excessively increased during the execution of the first temperature rise section P1 or the second temperature rise section P2, thereby destroying cells. Cool the skin (S) surface to prevent. On the other hand, the skin (S) cells degeneration near 50 degrees, the cells are destroyed, so even if the temperature rises should be maintained at a temperature of 50 degrees or less. Therefore, if the surface temperature (Tskin) of the skin (S) corresponds to 48 degrees by performing a margin, the cooling step (Pc) is performed.
  • the cooling step Pc uses a cooling unit (not shown) provided in the applicator 300 so as to quickly respond to the temperature of the skin S, and the control unit maintains the measured surface temperature Tskin of 48 degrees.
  • the output of the cooling unit can be controlled in response to the temperature.
  • such a cooling unit may be applied to the air-cooled or water-cooled, in the case of the air-cooled may be composed of a fan RPM control.
  • the end of the cooling step Pc may be configured to end when the surface temperature Tskin falls below 48 degrees or when the cooling time elapses for 5 minutes. This is to prevent the temperature Tfat of the object Vt from being lowered due to excessive heat loss from the skin S surface.
  • Temperature maintenance section (P3) corresponds to the step of maintaining the thermal equilibrium and to be able to treat the fat cells of the subject (Vt).
  • the surface temperature Tskin of the skin S does not exceed 50 ° C.
  • the temperature Tfat of the target object Vt can be maintained at the fat cell treatment temperature T2.
  • the temperature maintenance section P3 may be maintained for 10 minutes while maintaining the adipocyte treatment temperature T2 so that the adipocytes distributed in the subject Vt can be treated evenly.
  • adipocyte treatment temperature T2
  • T2 adipocyte treatment temperature
  • the temperature Tfat was close to 43 degrees from the experimental results.
  • 43 ° C. may be set as a reference temperature T1 for terminating the first temperature rise section Pc and entering the second temperature rise section Pc.
  • the cooling step Pc may be performed, and when maintained for 5 minutes, the temperature Tfat of the target object Vt is the fat cell treatment temperature. Reaching (T3) was found from the experimental results.
  • the object Vt rises above the adipocyte treatment temperature T2.
  • the fat cell treatment temperature (T2) On the contrary, if the third RF energy RF3 is too small, it is lowered below the fat cell treatment temperature T1, so that proper treatment is not performed.
  • the third RF energy RF3 was continuously transmitted at a power of 100 W for 10 minutes, the temperature Tfat of the target object Vt was maintained at 45 ° C., and the surface temperature Tskin of the skin S was at the surface. It could be obtained from the experimental results that the natural cooling falls below 45 ° C.
  • the power and transmission time of each of the aforementioned RF energy RF1, RF2, and RF3 are merely examples and may be set with appropriate margins in consideration of individual deviations.
  • each RF energy and the execution time of each step described above are examples, and may be set differently according to the treatment area and according to the patient.
  • the first RF energy RF1 may be configured to be delivered to three times or more than the third RF energy RF3 for rapid heating.
  • the durations of the first temperature rise section P1, the second temperature rise section P2, and the temperature maintenance section P3 may be determined and continued at predetermined ratios.
  • the duration of the second temperature rise section P2 is 50% to 100% of the first temperature rise section P1, and the duration of the temperature maintenance section P3.
  • the duration may be 50% to 200% of the first temperature rise section P1. Therefore, the first temperature rise section P1 may last longer than the second temperature rise section P2 to rapidly increase the temperature of the object Vt.
  • the duration may be determined according to the above-described duration ratio.
  • Figure 7 is a flow chart of the RF energy delivery method for adipocyte treatment.
  • RF energy delivery method for the treatment of fat cells may be configured to include a measuring step and a cooling step (S400).
  • the first RF energy delivery step S100 is a step of delivering the largest first RF energy of each step so as to quickly increase the temperature Tfat of the target object Vt in which the fat cells are distributed.
  • the first RF energy transfer step S100 may increase the object Vt to the reference temperature T1 by continuing for a predetermined temperature or a predetermined time.
  • the reference temperature T1 may be set to a temperature slightly lower than 45 ° C., which is the fat cell treatment temperature T2, and may be set to 40 ° C. to 44 ° C. This is to prevent the destruction of other tissues when the temperature of the skin surface is excessively raised or maintained at a high temperature.
  • the reference temperature (T1) is the target temperature (Vt) according to the surface temperature (Tskin), the running time, the size of the RF output, etc. previously obtained by the test. It can be estimated from a lookup table containing temperature (Tfat) data.
  • the surface temperature (Tskin) measurement step may continuously measure the temperature of the surface of the skin (S) while RF energy is transmitted, independently of the estimation of the temperature (Tfat) of the target object (Vt). Meanwhile, in the first RF energy transfer step S100 having a high temperature increase rate, the measurement may be made more frequently than in the other steps S200 and S300.
  • the second RF energy transfer step S200 is a second smaller than the first RF energy transfer step S100 so as to heat the object Vt at a lower temperature rise rate than when the first RF energy transfer step S100 is performed.
  • Delivers RF output The second RF energy transfer step S200 may be performed for a predetermined time by transmitting an RF output of 200 W, and a partial non-uniform temperature distribution may be uniformly distributed within the object Vt in the first RF energy transfer step S200.
  • the target object Vt is gradually heated so as to be heated.
  • the RF energy absorbed from the skin (S) layer is smaller than the amount of heat loss in the skin (S), the surface temperature (Tskin) is lowered and gradually reaches the stabilization stage.
  • the surface temperature Tskin measurement step is also performed in the second RF energy transfer step S200. If the surface temperature Tskin of the skin S reaches 42 degrees, the next step is performed.
  • the cooling step S400 is performed to cool the skin S surface to prevent damage to the skin S when the surface temperature Tskin of the skin S becomes higher than the required cooling temperature T3.
  • the skin (S) is performed to maintain the lower 48 degrees because the destruction of the cell occurs from about 50 degrees.
  • the temperature difference between the fat layer and the skin (S) is at least 3 degrees, so that even if the skin (S) is cooled, the fat layer is prevented from dropping below 45 degrees, the fat cell treatment temperature (T2).
  • the cooling step S400 may be configured to be performed only up to 5 minutes. And the cooling step (S400) stops cooling when the cooling required temperature (T3) or less.
  • the cooling step S400 may be configured by air cooling to finely adjust the surface temperature Tskin.
  • the third RF energy transfer step S300 may maintain the temperature by transferring RF energy corresponding to heat absorption and heat loss of the target object Vt so that the temperature Tfat of the target object Vt is kept constant.
  • the RF output of 100W is transmitted, the skin temperature (S) surface temperature (Tskin) can be maintained at about 42 degrees, the target object (Vt) can be maintained at 45 °C, and lasts about 10 minutes to be widely distributed within the subject (Vt) Many fat cells can be treated.
  • the fat cell surface temperature (T2) has been described with an example of 45 °C, this is only one example can exhibit an approximate effect even in the range of 44 °C to 46 °C.
  • the RF energy delivery device for adipocyte therapy and the RF energy delivery method for adipocyte therapy described above are composed of two or more stages of temperature rise so that the temperature can be increased at different temperatures. May be raised, and cooling is performed to prevent damage to the skin (S). Therefore, there is an effect that can shorten the overall time while maintaining the therapeutic effect of fat cells.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Electromagnetism (AREA)
  • Plasma & Fusion (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

The present invention relates to an RF energy transmitter and an RF energy transmission method, the RF energy transmitter comprising: an RF generator for generating RF energy; an applicator for transmitting the RF energy to an object volume in the body; and a control unit for variously controlling the size of the RF energy transmitted to respective temperature increasing section such that the plurality of temperature increasing sections can be distinguished and reach a therapeutic temperature when the RF energy is transmitted to the object volume. The RF transmitter and the RF energy transmission method, according to the present invention, enable reduction in the total time spent while maintaining treatment effects on adipocytes.

Description

RF에너지 전달장치 및 RF에너지 전달방법RF energy transfer device and RF energy transfer method
본 발명은 RF에너지 전달장치 및 RF에너지 전달방법에 관한 것이며, 보다 상세하게는 RF에너지를 전달하여 가열하고 세포를 치료하는 RF에너지 전달장치 및 RF에너지 전달방법에 관한 것이다.The present invention relates to an RF energy delivery device and an RF energy delivery method, and more particularly, to an RF energy delivery device and an RF energy delivery method for delivering heat by heating RF energy and treating cells.
최근 당뇨병, 고혈압 및 혈관 장애와 같은 성인병이 현대사회의 심각한 사회문제로 대두되고 있다. 이러한 성인병의 원인 중 하나는 비만으로 알려져있으며, 비만개선을 위하여 운동 및 칼로리 섭취의 억제를 통하여 체내 대사를 통해 지방을 소비하는 방법 등이 일반적으로 알려진 방법이다.Recently, adult diseases such as diabetes, hypertension and vascular disorders have emerged as serious social problems in modern society. One of the causes of the adult disease is known as obesity, and the method of consuming fat through the metabolism of the body through the suppression of exercise and calorie intake to improve obesity is generally known.
피하지방은 피부하층에 분포하는 지방세포가 축적되어 형성되며, 피하지방은 성숙시 일반세포에 비하여 매우 큰 부피를 갖게 되며, 이중 95% 정도의 지방을 포함하게 된다. 이러한 지방세포는 다른 세포에 비하여 적은 수분을 포함하고 있어 RF에너지를 전달한 경우 다른 세포에 비하여 더 높은 온도로 가열될 수 있다.Subcutaneous fat is formed by the accumulation of fat cells distributed in the subcutaneous layer, and subcutaneous fat has a much larger volume than normal cells when mature, and contains 95% of fat. These adipocytes contain less water than other cells and can be heated to higher temperatures than other cells when RF energy is delivered.
한편, 전술한 RF에너지를 전달하여 지방세포를 치료하는 기존의 방법은 지방세포를 가열하는데 많은 시간이 소요되어 비효율적인 문제점이 있었다.On the other hand, the conventional method of treating the fat cells by delivering the above-mentioned RF energy takes a lot of time to heat the fat cells there was an inefficient problem.
본 발명은 종래의 RF에너지를 전달하여 세포를 가열할 때 많은 시간이 소요되는 문제점을 해결하며, 과도한 RF전달시 발생하는 피부손상을 방지하기 위한 RF에너지 전달장치 및 RF에너지 전달방법을 제공하는 것에 있다.The present invention is to solve the problem that takes a long time when heating the cell by transmitting the conventional RF energy, to provide an RF energy delivery device and RF energy delivery method for preventing skin damage caused during excessive RF transmission. have.
RF에너지를 발생시키도록 구성된 RF제너레이터, 체내에 위치하는 대상체적에 RF에너지를 전달할 수 있도록 구성된 전극을 포함하는 어플리케이터, 및 대상체적에 RF에너지 전달 시 복수의 온도상승구간으로 구분되어 치료온도에 도달할 수 있도록 각 온도상승구간별로 전달되는 RF에너지의 크기를 상이하게 제어하는 제어부를 포함하는 RF에너지 전달장치가 제공된다.RF generator configured to generate RF energy, an applicator including an electrode configured to deliver RF energy to an object located in the body, and a plurality of temperature rise sections when RF energy is delivered to the object to reach a treatment temperature An RF energy transmission device including a control unit for differently controlling the magnitude of the RF energy transmitted for each temperature rise section is provided.
이때, 복수의 온도상승구간은 대상체적의 온도를 치료온도에 인접한 기준온도까지 신속하게 상승시키는 제1 온도상승구간 및 대상체적의 온도를 기준온도로부터 치료온도까지 상승시키는 제2 온도상승구간을 포함하여 구성될 수 있다.In this case, the plurality of temperature rise sections include a first temperature rise section for rapidly increasing the temperature of the object to a reference temperature adjacent to the treatment temperature and a second temperature rise section for increasing the temperature of the object from the reference temperature to the treatment temperature. Can be configured.
또한 제1 온도상승구간 동안 전달되는 제1 RF에너지는 대상체적의 온도를 신속하게 상승시킬 수 있도록 제2 온도상승구간동안 전달되는 제2 RF에너지보다 클 수 있다.In addition, the first RF energy delivered during the first temperature rise section may be greater than the second RF energy delivered during the second temperature rise section to rapidly increase the temperature of the object.
그리고 복수의 온도상승구간은, 제2 온도상승구간 이후 대상체적이 치료온도로 소정시간 유지되는 온도유지구간을 더 포함하며, 온도유지구간에는 제1 및 제2 온도상승구간에 전달되는 제1 및 제2 RF에너지보다 작은 제3 RF에너지를 전달될 수 있다.The plurality of temperature rising sections may further include a temperature holding section in which the subject maintains the treatment temperature for a predetermined time after the second temperature rising section, and the first and second temperature rising sections are transferred to the temperature holding section. Third RF energy smaller than the second RF energy may be delivered.
나아가 대상체적이 신속하게 치료온도에 도달할 수 있도록 제1 온도상승구간이 제2 온도상승구간보다 오래 지속될 수 있다.Furthermore, the first temperature rise section may last longer than the second temperature rise section so that the subject can quickly reach the treatment temperature.
그리고, 제2 온도상승구간의 지속시간은 제1 온도상승구간의 50% 내지 100%이며, 온도유지구간의 지속시간은 제1 온도상승구간의 50% 내지 200%일 수 있다.The duration of the second temperature rise section may be 50% to 100% of the first temperature rise section, and the duration of the temperature maintenance section may be 50% to 200% of the first temperature rise section.
한편, 어플리케이터는, 피부의 표면온도를 측정할 수 있도록 구성되는 온도센서 및 피부의 표면을 냉각할 수 있도록 구성되는 냉각부를 더 포함하며, 제어부는 표면온도가 냉각필요온도 이상이 되는 경우 냉각부를 구동시키도록 제어할 수 있다.On the other hand, the applicator further includes a temperature sensor configured to measure the surface temperature of the skin and a cooling unit configured to cool the surface of the skin, and the control unit drives the cooling unit when the surface temperature becomes higher than the required cooling temperature. Can be controlled.
이때, 냉각필요온도는 온도상승구간에서 피부의 손상을 방지할 수 있도록 48℃ 내지 50℃ 일 수 있다.At this time, the cooling required temperature may be 48 ℃ to 50 ℃ to prevent damage to the skin in the temperature rise section.
그리고 냉각부는, 표면온도가 급격하게 냉각되는 것을 방지할 수 있도록 공랭식으로 구성될 수 있다.The cooling unit may be configured to be air cooled to prevent the surface temperature from being rapidly cooled.
또한, 제어부는 냉각부의 구동시 대상체적의 온도가 하강하지 않도록 1회 구동시 5분 이내의 시간동안 구동킬 수 있다.In addition, the controller may be driven for a time within 5 minutes in one drive so that the temperature of the target object does not fall when the cooling unit is driven.
한편, 제어부는 제1 RF에너지의 크기는 제1 온도상승구간에서 대상체적이 기준온도에 신속하게 도달할 수 있도록 제3 RF에너지 크기의 3배 내지 5배가 되도록 제어할 수 있다.Meanwhile, the controller may control the size of the first RF energy to be 3 to 5 times the size of the third RF energy so that the subject can quickly reach the reference temperature in the first temperature rise section.
이때, 제1 RF에너지는 300W 내지 500W, 제2 RF에너지는 100W 내지 300W, 제3 RF에너지는 50W 내지 150W일 수 있다.In this case, the first RF energy may be 300W to 500W, the second RF energy may be 100W to 300W, and the third RF energy may be 50W to 150W.
그리고, 제1 온도상승구간은 5분 내지 15분, 제2 온도상승구간은 5분 내지 10분, 온도유지구간은 5분 내지 15분 지속될 수 있다.The first temperature rise section may last 5 minutes to 15 minutes, the second temperature rise section may last 5 minutes to 10 minutes, and the temperature maintenance section may last 5 minutes to 15 minutes.
여기서 대상체적은 지방세포를 포함하며, 치료온도는 지방세포가 변성되는 온도이며, 지방세포가 변성되는 온도는 44℃ 내지 46℃일 수 있다.Herein, the subject includes adipose cells, the treatment temperature is a temperature at which the fat cells are denatured, and a temperature at which the fat cells are denatured may be 44 ° C. to 46 ° C.
그리고 기준온도는 40℃ 내지 44℃일 수 있다.And the reference temperature may be 40 ℃ to 44 ℃.
한편, 제어부는 제1 온도상승구간동안 대상체적이 가장 큰 온도상승률로 가열될 수 있도록 제1 RF에너지 및 제2 RF에너지를 제어할 수 있다.On the other hand, the controller may control the first RF energy and the second RF energy so that the object can be heated to the largest temperature rise rate during the first temperature rise period.
추가로 대상체적을 제1 온도상승구간 동안 제1 RF출력을 전달하여 가열하는 제1 RF에너지 전달단계, 제1 온도상승구간보다 낮은 온도상승률로 온도상승이 이루어질 수 있도록 제2 온도상승구간 동안 제1 RF출력보다 작은 제2 RF출력을 전달하는 제2 RF에너지 전달단계, 대상체적이 치료되는 온도인 치료온도로 유지될 수 있도록 제2 RF출력보다 작은 제3 RF출력을 전달하는 제3 RF에너지 전달단계를 포함하여 구성될 수 있다. In addition, the first RF energy transfer step of heating the object by transmitting the first RF output during the first temperature rise section, during the second temperature rise section so that the temperature rise can be achieved at a temperature rise rate lower than the first temperature rise section. A second RF energy transfer step of delivering a second RF output smaller than the first RF output, and a third RF energy delivering a third RF output smaller than the second RF output so that the object can be maintained at a treatment temperature at which the object is treated It may be configured to include a delivery step.
여기서 대상체적이 치료온도에 인접한 기준온도에 도달하는 경우, 제1 RF에너지 전달단계는 종료되고 제2 RF에너지 전달단계가 수행되며, 대상체적이 치료온도에 도달하는 경우 제2 RF에너지 전달단계는 종료되고 제3 RF에너지 전달단계가 수행되며, 기준온도는 치료온도보다 낮을 수 있다.Here, when the subject reaches the reference temperature adjacent to the treatment temperature, the first RF energy transfer step is terminated and the second RF energy transfer step is performed, and when the subject reaches the treatment temperature, the second RF energy transfer step is performed. Terminating and the third RF energy transfer step is performed, the reference temperature may be lower than the treatment temperature.
이때, 제1 RF에너지 전달단계 및 제2 RF전달단계 수행 중, 대상체적에 인접하는 피부의 표면온도가 냉각필요온도에 해당하는 경우 피부를 냉각하는 냉각단계가 수행될 수 있다.At this time, during the first RF energy transfer step and the second RF transfer step, a cooling step of cooling the skin may be performed when the surface temperature of the skin adjacent to the object corresponds to the required cooling temperature.
그리고 제2 온도상승구간의 지속시간은 제1 온도상승구간의 50% 내지 100%이며, 온도유지구간의 지속시간은 제1 온도상승구간의 80% 내지 200%일 수 있다.The duration of the second temperature rise section may be 50% to 100% of the first temperature rise section, and the duration of the temperature maintenance section may be 80% to 200% of the first temperature rise section.
본 발명에 따른 RF에너지 전달장치 및 RF에너지 전달방법은 신속하게 치료온도로 가열할 수 있으므로 전체소요시간을 단축할 수 있으며, 과도한 에너지인가를 방지할 수 있어 안정성을 높일 수 있는 효과가 있다.The RF energy delivery device and the RF energy delivery method according to the present invention can be heated to a treatment temperature quickly, so that the overall time required can be shortened, and excessive energy can be prevented, thereby increasing stability.
도 1은 본 발명에 따른 지방세포 치료장치의 사시도이다.1 is a perspective view of an adipocyte treatment apparatus according to the present invention.
도 2는 지방세포 치료장치의 개념도이다.2 is a conceptual diagram of a fat cell treatment apparatus.
도 3는 지방세포 치료장치의 사용상태도이다.3 is a state diagram used in the treatment of fat cells.
도 4는 RF출력 전달 시 대상체적의 온도그래프이다.4 is a temperature graph of an object during RF output transmission.
도 5는 RF출력의 그래프이다.5 is a graph of RF output.
도 6은 냉각시의 사용상태도이다.6 is a state diagram used during cooling.
도 7은 지방세포 치료를 위한 RF에너지 전달방법의 순서도이다. Figure 7 is a flow chart of the RF energy delivery method for adipocyte treatment.
본 실시예는 RF 에너지를 전달하여 체내 지방을 줄이는 장치를 중심으로 설명하나, 이는 일 예이며 본 발명이 이에 한정되는 것은 아니다. 이 이외에도, RF 에너지를 치료 부위에 전달하여 치료를 진행하는 다양한 장치에 적용될 수 있음을 밝혀둔다. 또한 여기서 ‘치료’라 함은 조직의 재생을 위해 세포의 COAGULATION, ABULATION 등 조직의 변성 및 제거를 포함한 병변부위를 변화시켜 치료함을 말한다.This embodiment will be described with reference to a device for reducing body fat by delivering RF energy, but this is an example and the present invention is not limited thereto. In addition, it is noted that the RF energy can be applied to various devices for carrying out treatment by delivering RF energy to the treatment site. In addition, the term 'treatment' refers to treatment by changing the lesion site including degeneration and removal of tissues such as COAGULATION and ABULATION of cells for tissue regeneration.
이하에서는 본 발명의 일 실시예인 지방세포 치료장치에 대하여 도 1 내지 도 6을 참조하여 설명하도록 한다.Hereinafter will be described with reference to FIGS. 1 to 6 with respect to the adipocyte treatment apparatus of an embodiment of the present invention.
도 1은 본 발명에 따른 지방세포 치료장치의 사시도이다. 도시된 바와 같이, 본 발명에 따른 지방세포 치료장치는 어플리케이터(300), 링크(200), 몸체부(100)를 포함하여 구성된다. 1 is a perspective view of an adipocyte treatment apparatus according to the present invention. As shown, the adipocyte treatment apparatus according to the present invention comprises an applicator 300, a link 200, the body portion 100.
몸체부(100)는 RF에너지를 발생시키기 위한 구성 및 제어를 위한 사용자 인터페이스가 구비되며, 외부의 전원과 연결되어 RF에너지를 발생시키도록 구성된다. 또한 RF에너지의 크기 및 시간 등의 제어를 포함하여 장치의 전체적인 제어를 수행하는 구성요소를 포함한다. Body portion 100 is provided with a user interface for configuration and control for generating RF energy, is configured to generate RF energy in connection with an external power source. It also includes components that perform overall control of the device, including control of size and time of RF energy.
어플리케이터(300)는 신체에 인접하여 배치되고 체내로 RF에너지를 전달하도록 구성된다. 어플리케이터(300)는 어플리케이터 바디(310), 안테나(320), 온도센서(330), 냉각부(340) 및 가이드부(350)를 포함하여 구성될 수 있다.The applicator 300 is disposed adjacent to the body and is configured to deliver RF energy into the body. The applicator 300 may include an applicator body 310, an antenna 320, a temperature sensor 330, a cooling unit 340, and a guide unit 350.
링크(200)는 몸체부(100)와 어플리케이터(300)를 기구적으로 연결하여 어플리케이터(300)를 고정할 수 있도록 구성된다. 링크(200)는 어플리케이터(300)가 다양한 위치에 배치될 수 있도록 복수의 관절을 포함하여 구성될 수 있다. The link 200 is configured to mechanically connect the body part 100 and the applicator 300 to fix the applicator 300. The link 200 may be configured to include a plurality of joints so that the applicator 300 may be disposed at various positions.
이하에서는 각 구성요소를 도 2 및 도 3을 참조하여 상세히 설명하도록 한다.Hereinafter, each component will be described in detail with reference to FIGS. 2 and 3.
도 2는 지방세포 치료장치의 개념도이다.2 is a conceptual diagram of a fat cell treatment apparatus.
도시된 바와 같이, 몸체부(100)는 전원 공급부(110), RF회로, 사용자 인터페이스부(미도시), 데이터 저장부(170) 및 제어부(140)를 포함하여 구성되며, 어플리케이터(300)는 안테나(320), 온도센서(330), 냉각팬(미도시) 및 가이드부(350)를 포함하여 구성된다.As shown, the body portion 100 is configured to include a power supply 110, an RF circuit, a user interface (not shown), a data storage unit 170 and the control unit 140, the applicator 300 is It is configured to include an antenna 320, a temperature sensor 330, a cooling fan (not shown) and the guide unit 350.
전원 공급부(110)는 외부전원과 연결되며, RF회로, 인터페이스부(160) 및 제어부(140)를 포함한 다른 전기적 구성요소와 연결된다. The power supply unit 110 is connected to an external power source and is connected to other electrical components including the RF circuit, the interface unit 160, and the controller 140.
RF회로는 전원 공급부(110)로부터 전달된 에너지를 RF로 변조하여 어플리케이터(300)에 전달하도록 구성된다. RF회로는 RF 제너레이터(120), 발룬 회로(130), 1차 및 2차 트랜스포머(미도시)를 포함하여 구성될 수 있다. 한편, 도시되지는 않았으나, RF회로는 변조, 밸런스, 매칭 등을 수행하기 위한 부수적인 구성요소를 포함하여 구성될 수 있다.The RF circuit is configured to modulate the energy delivered from the power supply 110 into RF and deliver it to the applicator 300. The RF circuit may include an RF generator 120, a balloon circuit 130, and primary and secondary transformers (not shown). Although not shown, the RF circuit may include ancillary components for performing modulation, balance, matching, and the like.
RF 제너레이터(120)는 전달된 에너지를 RF(Radio Frequancy)로 변조하도록 구성된다. 본 실시예에 따른 RF 제너레이터(430)는 27.12MHz의 주파수를 갖는 RF 에너지를 발생시키도록 구성되며, 이 이외에도 13.553~13.567MHz, 26.975~27.283MHz, 40.66~40.70MHz 등과 같이 ISM 대역의 주파수에 해당하는 RF 에너지를 발생시키도록 구성될 수 있다. 발룬회로(130)는 RF에너지 전달시 언발란스드(unbalanced) 임피던스를 발란스드(balanced) 임피던스로 변조할 수 있게 된다. 1차 및 2차 트랜스포머는 임피던스 매칭을 수행한다. 한편 이와같은 전기적 구성요소의 구성은 일반적으로 널리 쓰이는 구성이므로 세부적인 구성에 대하여는 상세한 설명을 생략하도록 한다.The RF generator 120 is configured to modulate the delivered energy into Radio Frequancy (RF). The RF generator 430 according to the present embodiment is configured to generate RF energy having a frequency of 27.12 MHz. In addition, the RF generator 430 corresponds to a frequency of an ISM band such as 13.553 to 13.567 MHz, 26.975 to 27.283 MHz, and 40.66 to 40.70 MHz. Can be configured to generate RF energy. The balun circuit 130 may modulate an unbalanced impedance into a balanced impedance when transmitting RF energy. The primary and secondary transformers perform impedance matching. On the other hand, since the configuration of such an electrical component is generally used configuration, detailed description of the detailed configuration will be omitted.
인터페이스부(160)는 사용자로부터 조작입력 및 현 상태 등을 알릴 수 있도록 구성된다. 인터페이스부(160)는 영상 출력부(미도시) 및 오디오 출력부(미도시)를 포함하여 구성될 수 있다. 영상 출력부 및 오디오 출력부는 몸체부(100)의 외면에 구비될 수 있다.The interface unit 160 is configured to notify a user of an operation input, a current state, and the like. The interface unit 160 may include an image output unit (not shown) and an audio output unit (not shown). The image output unit and the audio output unit may be provided on an outer surface of the body unit 100.
데이터 저장부(170)는 장치의 운용시 필요한 다양한 정보가 저장될 수 있으며, 프로토콜에 대한 정보 및 현재 환자의 체내 임피던스 등의 상태에 대응하여 RF에너지를 제어하는 알고리즘 등이 저장될 수 있다.The data storage unit 170 may store various information necessary for operating the device, and may store information about protocols and algorithms for controlling RF energy in response to a current state of the patient's body impedance.
제어부(140)는 입력, 출력, RF회로를 포함한 구성요소의 제어를 수행할 수 있도록 구성된다. 제어부(140)는 각각의 전기적 구성요소와 연결되어 신호처리를 수행할 수 있고, 데이터 저장부(170)에 저장된 알고리즘에 따라 제어가 수행될 수 있다. 또한 어플리케이터(300)에 구비된 온도센서(330) 및 냉각팬과 연결되어 센싱값에 따라 냉각팬의 출력을 조절할 수 있도록 구성된다. 한편 이와같은 제어부(140)의 RF에너지 제어에 관하여는 차후 상세히 설명하도록 한다.The controller 140 is configured to perform control of components including input, output, and RF circuits. The controller 140 may be connected to each electrical component to perform signal processing, and control may be performed according to an algorithm stored in the data storage unit 170. In addition, the temperature sensor 330 and the cooling fan provided in the applicator 300 is configured to adjust the output of the cooling fan according to the sensing value. Meanwhile, the RF energy control of the controller 140 will be described in detail later.
어플리케이터(300)는 전술한 바와 같이 환자에 인접하여 배치되어 RF에너지를 인체에 적용시킬 수 있도록 구성된다. 어플리케이터(300)는 어플리케이터 바디(310), 안테나(320), 온도센서(330), 냉각팬(미도시), 가이드부(350)를 포함하여 구성된다.The applicator 300 is configured to be disposed adjacent to the patient as described above to apply RF energy to the human body. The applicator 300 includes an applicator body 310, an antenna 320, a temperature sensor 330, a cooling fan (not shown), and a guide unit 350.
어플리케이터 바디(310)는 환자의 신체중 대면적에 RF에너지를 적용시킬 수 있도록 복부의 평균 폭에 대응되는 크기로 구성될 수 있다. 어플리케이터 바디(310)는 내측에 안테나(320) 및 온도센서(330) 및 냉각부(340)가 구비될 수 있다. 어플리케이터 바디(310)는 운용시 RF에너지가 피하지방층에 효율적으로 전달될 수 있도록 피부(S)와 적절한 이격거리를 두어 배치될 수 있다. 이때, 냉각부(340)는 몸체부(100)로부터 공기를 전달받을 수 있도록 튜브를 포함하여 구성될 수 있으며, 냉각풍은 어플리케이터 바디(310)에 형성된 다수의 홀을 통하여 피부에 냉강풍을 제공할 수 있다. 다만, 전술한 냉각부의 구성은 일 예일뿐, 어플리케이터 바디(310)에 구비된 팬(미도시)으로 구성될 수 있다.The applicator body 310 may be configured in a size corresponding to the average width of the abdomen to apply RF energy to a large area of the patient's body. The applicator body 310 may be provided with an antenna 320, a temperature sensor 330, and a cooling unit 340 therein. The applicator body 310 may be disposed at an appropriate distance from the skin (S) so that the RF energy can be efficiently transmitted to the subcutaneous fat layer during operation. At this time, the cooling unit 340 may be configured to include a tube to receive the air from the body portion 100, the cooling wind provides a cold strong wind to the skin through a plurality of holes formed in the applicator body 310 can do. However, the configuration of the cooling unit described above is just an example, and may be configured as a fan (not shown) provided in the applicator body 310.
가이드부(350)는 장치의 운용시 어플리케이터 바디(310)가 배치된 부분에서 이탈하지 않도록 구성되며, 환자의 신체 굴곡에 따라 어플리케이터(300)를 가이드할 수 있도록 어플리케이터 바디(310)와 연결되며, 회동가능하도록 구성될 수 있다.The guide unit 350 is configured not to be separated from the portion where the applicator body 310 is disposed when the device is operated, and is connected to the applicator body 310 to guide the applicator 300 according to the body curvature of the patient. It can be configured to be rotatable.
도 3는 지방세포 치료장치의 사용상태도이다.3 is a state diagram used in the treatment of fat cells.
도시된 바와 같이, 두 개의 안테나(320)가 치료 위치에 이격 배치된 상태에서 RF 에너지를 환자의 대상체적(Vt)에 전달하는 방식으로 치료가 진행된다. 치료는 대상체적(Vt)의 피하 지방을 줄이기 위한 목적으로 이루어진다. 피하 지방(빗금친 영역)을 섭씨 45도 이상의 온도로 소정 시간 동안 유지시켜 지방 세포를 사멸시킬 수 있게 된다.. 따라서, 제어부(140)는 안테나(230)를 통해 RF 에너지를 치료 위치에 전달하여 피하 지방의 온도를 치료온도로 상승시키며 소정시간 유지될 수 있도록 복수의 구성요소를 제어한다. 치료온도는 섭씨 45도 내지 50도가 될 수 있다. 한편, 한 쌍의 전극을 예를 들어 설명하였으나, 하나의 유도성 전극, 복수의 용량성 전극으로 구성되어 RF에너지를 전달하도록 구성될 수 있다.As shown, treatment proceeds in a manner that delivers RF energy to the patient's subject Vt with two antennas 320 spaced apart at the treatment location. Treatment is aimed at reducing the subcutaneous fat of the subject (Vt). By maintaining the subcutaneous fat (hatched area) at a temperature of 45 degrees Celsius or more for a predetermined time it is possible to kill fat cells. Therefore, the control unit 140 transmits the RF energy to the treatment position through the antenna 230 The plurality of components are controlled to increase the temperature of the subcutaneous fat to the treatment temperature and to be maintained for a predetermined time. The treatment temperature can be 45 degrees to 50 degrees Celsius. Meanwhile, although a pair of electrodes has been described as an example, one pair of inductive electrodes and a plurality of capacitive electrodes may be configured to deliver RF energy.
도 4는 RF에너지 전달시 대상체적(Vt)의 온도(Tfat)그래프이며, 도 5는 RF에너지의 그래프이고, 도 6은 냉각시의 사용상태도이다.4 is a graph of a temperature (Tfat) of the target object (Vt) during RF energy transfer, FIG. 5 is a graph of RF energy, and FIG. 6 is a diagram showing a state of use during cooling.
도 4에 도시된 바와 같이 RF에너지 전달시 피하지방을 포함한 신체 조직의 각 부분의 온도가 상승된다. , 구체적으로 시간에 따른 대상체적(Vt)의 온도(Tfat)와 그에 인접한 피부(S)의 표면온도(Tskin) 그래프가 나타나 있다.As shown in FIG. 4, the temperature of each part of the body tissue including subcutaneous fat is increased during RF energy delivery. Specifically, the temperature Tfat of the target object Vt and the surface temperature Tskin of the skin S adjacent thereto are shown with time.
RF에너지의 전달은 제어부(140)가 전달하는 에너지의 크기에 따라 에너지 전달단계를 제1 온도상승구간(P1), 제2 온도상승구간(P2), 온도유지구간(P3)으로 구분될 수 있으며, 또한 냉각단계(Pc)로 구분되어 수행될 수 있다.The transfer of RF energy may be divided into an energy transfer step into a first temperature rise section P1, a second temperature rise section P2, and a temperature maintenance section P3 according to the magnitude of energy delivered by the controller 140. In addition, the cooling step (Pc) may be performed by dividing.
제1 온도상승구간(P1)은 지방세포가 분포되어 있는 대상체적(Vt)을 신속하게 기준온도(T1)에 도달할 수 있도록 가장 큰 제1 RF에너지를 전달하는 단계이다. 일반적으로 지방층은 피부나 근육에 비하여 혈액이나 표면에 의한 열전달이 잘 이루어지지 않으므로 흡수한 에너지가 쉽게 발산되지 않는다. 따라서 전달되는 RF에너지가 클수록 대상체적(Vt)의 온도(Tfat)는 빠르게 상승하게 된다. 따라서 제1 온도상승구간(P1)에는 가장 큰 파워로 RF에너지를 전달하여 대상체적(Vt)이 전체 구간 중 가장 온도가 빠르게 상승하는 제1 온도상승률이 나타나게 된다.The first temperature rise section P1 is a step of delivering the largest first RF energy to rapidly reach the target temperature T1 in which the fat cells are distributed, to the reference temperature T1. In general, the fat layer is less heat transfer by the blood or surface than the skin or muscle, so absorbed energy is not easily released. Therefore, the larger the transmitted RF energy, the faster the temperature Tfat of the target object Vt rises. Therefore, the first temperature rise rate is shown in the first temperature rise section (P1) by transferring the RF energy with the largest power, the object temperature (Vt) is the fastest temperature of the entire section.
온도상승률과 관련하여, 일정한 크기 내의 RF에너지를 전달하는 경우 지방층, 피부(S) 및 근육의 온도상승률은 서로 다르게 나타난다. 지방층의 온도는 손실되는 열량이 다른조직에 비해 적으나, 근육의 경우 혈액에 의한 냉각효과가 있으며, 또한 피부(S)는 표면에서 공기에 의해 냉각되는 열손실이 있어 지방체적보다 온도가 더 낮을 수 있다.(Tskin') Regarding the rate of temperature rise, the rate of temperature rise of fat layer, skin (S) and muscle is different when delivering RF energy within a certain size. The temperature of the fat layer is less heat than other tissues, but in the case of muscles, it has a cooling effect by blood, and the skin (S) has a lower temperature than fat volume due to heat loss cooling by air on the surface. (Tskin ')
그러나 일정 출력 이상의 RF에너지가 전달되면 피부(S)층에서 흡수되는 열은 표면에서의 열손실보다 크게 되고 이 경우 표면온도(Tskin)가 지방층보다 온도가 높아지는 온도역전이 일어난다. 제1 온도상승구간(P1)에서는 이와같은 온도역전이 일어날 수 있을 정도의 큰 제1 RF에너지(RF1)를 전달하여 대상체적(Vt)을 가열하게 된다. 이때 피부(S)의 표면온도(Tskin)의 급격한 상승이 이루어 질 수 있으며, 표면에서 공기에 의한 자연적인 냉각이 이루어지더라도 지속적으로 온도가 상승하게 된다. 한편, 피부(S)의 표면온도(Tskin)은 피부세포가 변성될 만큼 고온까지 상승할 수 있게 되므로 이를 방지하기 위하여 냉각단계(Pc)가 수행될 수 있다. 이에 대하여는 차후 설명하기로 한다. However, when RF energy is delivered above a certain output, the heat absorbed from the skin layer is greater than the heat loss at the surface. In this case, the temperature reversal occurs when the surface temperature is higher than the fat layer. In the first temperature rise section P1, the first RF energy RF1 large enough to cause such a temperature reversal may be transferred to heat the object Vt. At this time, the surface temperature (Tskin) of the skin (S) can be raised rapidly, even if the natural cooling by the air on the surface is constantly rising the temperature. On the other hand, since the surface temperature (Tskin) of the skin (S) can rise to a high temperature so that the skin cells are denatured, the cooling step (Pc) may be performed to prevent this. This will be described later.
제1 온도상승구간(P1)에서 전달되는 제1 RF에너지(RF1)는 300W 내지 500W의 파워로 전달 될 수 있으며, 이 경우 대상체적(Vt)의 온도(Tfat)가 과도하게 상승하는 것을 방지하기 위하여 5분 내지 15분 이내로 수행될 수 있다. 제1 온도상승구간(P1)은 대상체적(Vt)의 온도(Tfat)가 기준온도(T1)에 해당하는 경우 종료되고 다음 단계인 제2 온도상승구간(P2)에 진입할 수 있도록 다른 크기의 RF에너지가 전달될 수 있다. The first RF energy RF1 transmitted from the first temperature rise section P1 may be transmitted at a power of 300 W to 500 W, and in this case, to prevent the temperature Tfat of the object Vt from excessively rising. In order to be carried out within 5 to 15 minutes. The first temperature increase section P1 is terminated when the temperature Tfat of the target object Vt corresponds to the reference temperature T1 and is of a different size so as to enter the second temperature rise section P2 which is the next step. RF energy can be delivered.
제2 온도상승구간(P2)은 대상체적(Vt)의 열분포를 안정화시키기 위한 단계에 해당한다. 제1 온도상승구간(P1)에서 대상체적(Vt) 내의 조직이 급격하게 온도가 증가된 경우 미시적인 관점에서 볼 때 부분적으로 온도편차가 발생되는 영역이 나타나게 된다.. 제2 온도상승구간(P2)에서는 온도편차가 발생하는 영역이 주변과의 열교환으로 전체적으로 균일한 온도분포를 가질 수 있도록 제1 RF에너지(RF1)보다 작은 제2 RF에너지(RF2)를 전달하게 된다. 이때 제2 RF에너지(RF2)의 크기는 대상체적(Vt)의 온도(Tfat)가 제1 온도상승률보다 작은 제2 온도상승률로 온도가 상승할 수 있는 크기로 결정된다.The second temperature rise section P2 corresponds to a step for stabilizing the heat distribution of the target object Vt. In the case where the tissue in the object area Vt is rapidly increased in temperature in the first temperature rise section P1, a region in which a temperature deviation occurs partially appears from the microscopic view. The second temperature rise section P2 ) Transmits the second RF energy RF2 smaller than the first RF energy RF1 so that the region where the temperature deviation occurs has a uniform temperature distribution as a whole by heat exchange with the surroundings. In this case, the size of the second RF energy RF2 is determined as a size at which the temperature may rise at a second temperature rise rate at which the temperature Tfat of the target object Vt is smaller than the first temperature rise rate.
제2 RF에너지(RF2)의 크기가 200W인 경우 5분 이내로 균일한 온도분포를 갖게 되며 지방세포치료온도(T2)까지 상승됨을 실험을 통하여 얻을 수 있었다. 따라서 제2 온도상승구간(P2)은 제2 RF에너지(RF2)가 100W 내지 300W의 파워로 전달되며, 지속시간은 5분 내지 10분 정도로 이루어질 수 있다. 한편, 제2 RF에너지(RF2) 전달 중에도 피부(S)에 에너지가 전달되어 온도가 상승할 수 있으므로, 이 경우에도 피부의 표면온도(Tskin)가 냉각필요온도(T3)로 상승하는 경우 냉각단계(Pc)가 수행될 수 있도록 제어부가 기능한다.When the size of the second RF energy (RF2) is 200W it can be obtained through the experiment to have a uniform temperature distribution within 5 minutes and to rise to the fat cell treatment temperature (T2). Therefore, the second temperature rise section P2 is the second RF energy (RF2) is delivered at a power of 100W to 300W, the duration may be made of about 5 to 10 minutes. On the other hand, the energy is transferred to the skin (S) during the second RF energy (RF2) transfer, so that the temperature can rise, even in this case, if the surface temperature (Tskin) of the skin rises to the required cooling temperature (T3) cooling step The controller functions to perform (Pc).
이하에서는 냉각단계(Pc)에 대하여 상세히 설명하도록 한다.Hereinafter, the cooling step Pc will be described in detail.
도 6에 도시된 바와 같이, 냉각단계(Pc)는 제1 온도상승구간(P1) 또는 제2 온도상승구간(P2)의 수행 중 피부(S)의 온도가 과도하게 상승하여 세포가 파괴되는 것을 방지하도록 피부(S) 표면을 냉각한다. 한편 피부(S)세포는 50도 근처에서 변성이 일어나 세포가 파괴되므로 온도가 상승하더라도 50도 이하의 온도로 유지되어야 한다. 따라서 마진을 두어 피부(S)의 표면온도(Tskin)가 48도에 해당하는 경우 냉각단계(Pc)를 수행한다. 냉각단계(Pc)는 피부(S) 온도에 따라 신속하게 대응할 수 있도록 어플리케이터(300)에 구비된 냉각부(미도시)를 이용하게 되며, 제어부는 측정되는 표면온도(Tskin)가 48도를 유지할 수 있도록 온도에 대응하여 냉각부의 출력을 제어할 수 있다. 한편, 이러한 냉각부는 공랭식 또는 수랭식으로 적용될 수 있으며, 공랭식의 경우 RPM이 조절되는 팬으로 구성될 수 있다.As shown in FIG. 6, in the cooling step Pc, the temperature of the skin S is excessively increased during the execution of the first temperature rise section P1 or the second temperature rise section P2, thereby destroying cells. Cool the skin (S) surface to prevent. On the other hand, the skin (S) cells degeneration near 50 degrees, the cells are destroyed, so even if the temperature rises should be maintained at a temperature of 50 degrees or less. Therefore, if the surface temperature (Tskin) of the skin (S) corresponds to 48 degrees by performing a margin, the cooling step (Pc) is performed. The cooling step Pc uses a cooling unit (not shown) provided in the applicator 300 so as to quickly respond to the temperature of the skin S, and the control unit maintains the measured surface temperature Tskin of 48 degrees. The output of the cooling unit can be controlled in response to the temperature. On the other hand, such a cooling unit may be applied to the air-cooled or water-cooled, in the case of the air-cooled may be composed of a fan RPM control.
냉각단계(Pc)의 종료는 표면온도(Tskin)가 48도 이하로 내려가는 경우 또는 냉각시간이 5분 경과시 종료되도록 구성될 수 있다. 피부(S)표면으로부터 지나친 열손실로 대상체적(Vt)의 온도(Tfat)가 낮아지는 것을 방지하기 위함이다.The end of the cooling step Pc may be configured to end when the surface temperature Tskin falls below 48 degrees or when the cooling time elapses for 5 minutes. This is to prevent the temperature Tfat of the object Vt from being lowered due to excessive heat loss from the skin S surface.
온도유지구간(P3)은 열평형상태를 유지하며 대상체적(Vt)의 지방세포를 치료시킬 수 있도록 유지하는 단계에 해당한다. 이 경우 피부(S)의 표면온도(Tskin)는 50℃를 넘지 않고 대상체적(Vt)의 온도(Tfat)는 지방세포치료온도(T2)로 유지될 수 있는 크기의 제3 RF에너지(RF3)가 전달될 수 있다. 온도유지구간(P3)는 대상체적(Vt)에 분포하는 지방세포가 고르게 치료될 수 있도록 지방세포치료온도(T2)로 유지하면서 10분간 지속될 수 있다Temperature maintenance section (P3) corresponds to the step of maintaining the thermal equilibrium and to be able to treat the fat cells of the subject (Vt). In this case, the surface temperature Tskin of the skin S does not exceed 50 ° C., and the temperature Tfat of the target object Vt can be maintained at the fat cell treatment temperature T2. Can be delivered. The temperature maintenance section P3 may be maintained for 10 minutes while maintaining the adipocyte treatment temperature T2 so that the adipocytes distributed in the subject Vt can be treated evenly.
한편, 지방세포치료온도(T2)는 일반적으로 45도에서 10분 이상 유지하면 치료할 수 있는 것으로 알려져 있다. 한편 RF에너지의 전달 중 지방층의 온도를 직접 측정하는 방법은 부적절하므로 실험데이터를 통하여 RF에너지의 크기 및 전달시간이 결정될 수 있다. On the other hand, adipocyte treatment temperature (T2) is generally known to be curable if kept at 45 degrees for 10 minutes or more. On the other hand, the method of directly measuring the temperature of the fat layer during the delivery of RF energy is inappropriate, so the size and delivery time of the RF energy can be determined through experimental data.
일 예로, 제1 온도상승구간(P1)에서 제1 RF에너지를 300W의 파워로 전달된 경우 냉각단계(Pc)가 동시에 피부표면온도(Tskin)를 48℃이하로 유지되면 대상체적(Vt)의 온도(Tfat)는 43도에 인접하는 것을 실험결과로부터 얻을 수 있었다. 이때 43℃는 제1 온도상승구간(Pc)을 종료하고 제2 온도상승구간(Pc)에 진입하기 위한 기준온도(T1)로 설정될 수 있다.For example, when the first RF energy is delivered at a power of 300W in the first temperature rise section P1, when the cooling step Pc simultaneously maintains the skin surface temperature Tskin below 48 ° C, The temperature Tfat was close to 43 degrees from the experimental results. In this case, 43 ° C. may be set as a reference temperature T1 for terminating the first temperature rise section Pc and entering the second temperature rise section Pc.
제2 온도상승구간에서 제2 RF에너지가 200W의 파워로 전달되는 경우에도 냉각단계(Pc)가 수행될 수 있으며, 5분간 유지한 경우 대상체적(Vt)의 온도(Tfat)는 지방세포치료온도(T3)에 도달하는 것을 실험결과로부터 알 수 있었다.Even if the second RF energy is delivered at a power of 200 W in the second temperature rise section, the cooling step Pc may be performed, and when maintained for 5 minutes, the temperature Tfat of the target object Vt is the fat cell treatment temperature. Reaching (T3) was found from the experimental results.
온도유지구간(P3)에서 제3 RF에너지(RF3)가 너무 크면 대상체적(Vt)이 지방세포치료온도(T2) 이상으로 상승한다. 한편 과도한 과열은 조직의 필요이상의 손상을 초래할 수 있으므로 지방세포치료온도(T2)를 넘지 않도록 유지하는 것이 바람직하다. 이와 반대로 제3 RF에너지(RF3)가 너무 작으면 지방세포치료온도(T1)이하로 낮아져 적절한 치료가 이루어지지 않는다. 이때, 제3 RF에너지(RF3)를 100W의 파워로 10분간 지속적으로 전달한 경우 대상체적(Vt)의 온도(Tfat)는 45℃를 유지하였으며, 피부(S)의 표면온도(Tskin)는 표면에서 자연냉각에 의해 45℃도 이하로 떨어짐을 실험결과로부터 얻을 수 있었다.If the third RF energy RF3 is too large in the temperature maintenance section P3, the object Vt rises above the adipocyte treatment temperature T2. On the other hand, excessive overheating may cause damage to tissues more than necessary, so it is desirable to maintain the fat cell treatment temperature (T2). On the contrary, if the third RF energy RF3 is too small, it is lowered below the fat cell treatment temperature T1, so that proper treatment is not performed. At this time, when the third RF energy RF3 was continuously transmitted at a power of 100 W for 10 minutes, the temperature Tfat of the target object Vt was maintained at 45 ° C., and the surface temperature Tskin of the skin S was at the surface. It could be obtained from the experimental results that the natural cooling falls below 45 ° C.
앞서 전술한 각 RF에너지(RF1, RF2, RF3)의 파워의및 전달시간은 일예일 뿐 개인별 편차 등을 고려하여 적절한 마진을 두고 설정될 수 있다.The power and transmission time of each of the aforementioned RF energy RF1, RF2, and RF3 are merely examples and may be set with appropriate margins in consideration of individual deviations.
다만, 이상에서 설명한 각 RF에너지의 크기 및 각 단계의 수행시간은 일 예이며, 환자에 따라, 치료부위에 따라 각각 다르게 설정될 수 있다. 그리고 제1 RF에너지(RF1)는 신속한 가열을 위하여 제3 RF에너지(RF3)보다 3배 이상의 크기로 전달되도록 구성될 수 있다. However, the magnitude of each RF energy and the execution time of each step described above are examples, and may be set differently according to the treatment area and according to the patient. In addition, the first RF energy RF1 may be configured to be delivered to three times or more than the third RF energy RF3 for rapid heating.
또한 제1 온도상승구간(P1), 제2 온도상승구간(P2) 및 온도유지구간(P3)의 지속시간은 상호간 소정비율로 결정되어 지속될 수 있다. 제1 온도상승구간(P1)과 비교하여 볼 때, 제2 온도상승구간(P2)의 지속시간은 제1 온도상승구간(P1)의 50% 내지 100%가 되며, 온도유지구간(P3)의 지속시간은 제1 온도상승구간(P1)의 50% 내지 200% 가 될 수 있다. 따라서 제1 온도상승구간(P1)은 제2 온도상승구간(P2)보다 더 오래 지속되어 대상체적(Vt)의 온도를 신속하게 상승시킬 수 있게 된다. 한편 전체 치료 시간이 25분 이하로 설정된 경우 전술한 지속시간 비율에 따라 지속시간이 결정될 수 있다.In addition, the durations of the first temperature rise section P1, the second temperature rise section P2, and the temperature maintenance section P3 may be determined and continued at predetermined ratios. Compared with the first temperature rise section P1, the duration of the second temperature rise section P2 is 50% to 100% of the first temperature rise section P1, and the duration of the temperature maintenance section P3. The duration may be 50% to 200% of the first temperature rise section P1. Therefore, the first temperature rise section P1 may last longer than the second temperature rise section P2 to rapidly increase the temperature of the object Vt. On the other hand, if the total treatment time is set to 25 minutes or less, the duration may be determined according to the above-described duration ratio.
이하에서는 본 발명에 따른 다른 실시예인 지방세포 치료를 위한 RF에너지 전달방법에 대하여 설명하기로 한다.Hereinafter will be described an RF energy delivery method for adipocyte treatment according to another embodiment of the present invention.
도 7은 지방세포 치료를 위한 RF에너지 전달방법의 순서도이다. Figure 7 is a flow chart of the RF energy delivery method for adipocyte treatment.
도시된 바와 같이, 지방세포 치료를 위한 RF에너지 전달방법은 제1 RF에너지 전달단계(S100), 제2 RF에너지 전달단계(S200) 및 제3 RF에너지 전달단계(S300), 표면온도(Tskin)측정단계 및 냉각단계(S400)를 포함하여 구성될 수 있다. As shown, RF energy delivery method for the treatment of fat cells, the first RF energy delivery step (S100), the second RF energy delivery step (S200) and the third RF energy delivery step (S300), surface temperature (Tskin) It may be configured to include a measuring step and a cooling step (S400).
제1 RF에너지 전달단계(S100)는 지방세포가 분포하는 대상체적(Vt)의 온도(Tfat)를 신속하게 상승시킬 수 있도록 각 단계 중 가장 큰 제1 RF에너지를 전달하는 단계이다. 제1 RF에너지 전달단계(S100)는 소정온도 또는 소정시간동안 지속하여 대상체적(Vt)을 기준온도(T1)까지 상승시킬 수 있다. 기준온도(T1)는 지방세포치료온도(T2)인 45℃보다 다소 낮은 온도로 설정될 수 있으며, 40℃ 내지 44℃로 설정될 수 있다. 피부표면의 온도가 과도하게 상승하거나 고온으로 유지되는 경우 다른 조직들이 파괴되는 것을 방지하기 위함이다.The first RF energy delivery step S100 is a step of delivering the largest first RF energy of each step so as to quickly increase the temperature Tfat of the target object Vt in which the fat cells are distributed. The first RF energy transfer step S100 may increase the object Vt to the reference temperature T1 by continuing for a predetermined temperature or a predetermined time. The reference temperature T1 may be set to a temperature slightly lower than 45 ° C., which is the fat cell treatment temperature T2, and may be set to 40 ° C. to 44 ° C. This is to prevent the destruction of other tissues when the temperature of the skin surface is excessively raised or maintained at a high temperature.
RF에너지를 전달하는 중에는 지방층의 온도를 측정하는 것이 바람직하지 않으므로, 기준온도(T1)는 기존에 시험으로 획득된 표면온도(Tskin), 진행시간, RF출력의 크기 등에 따른 대상체적(Vt)의 온도(Tfat) 데이터를 포함한 룩업테이블에서 추정할 수 있게 된다.Since it is not preferable to measure the temperature of the fat layer during the transfer of RF energy, the reference temperature (T1) is the target temperature (Vt) according to the surface temperature (Tskin), the running time, the size of the RF output, etc. previously obtained by the test. It can be estimated from a lookup table containing temperature (Tfat) data.
표면온도(Tskin)측정단계는 대상체적(Vt)의 온도(Tfat)의 추정과 별개로 RF에너지가 전달되는 동안 지속적으로 피부(S)표면의 온도를 측정할 수 있다. 한편 온도상승률이 높은 제1 RF에너지 전달단계(S100)에서는 다른 단계(S200, S300)에서보다 더 빈번하게 측정이 이루어질 수 있다.The surface temperature (Tskin) measurement step may continuously measure the temperature of the surface of the skin (S) while RF energy is transmitted, independently of the estimation of the temperature (Tfat) of the target object (Vt). Meanwhile, in the first RF energy transfer step S100 having a high temperature increase rate, the measurement may be made more frequently than in the other steps S200 and S300.
제2 RF에너지 전달단계(S200)는 대상체적(Vt)을 제1 RF에너지 전달단계(S100)의 수행시보다 낮은 온도상승률로 가열할 수 있도록 제1 RF에너지 전달단계(S100)보다 작은 제2 RF출력을 전달한다. 제2 RF에너지 전달단계(S200)는 200W의 RF출력을 전달하여 소정시간 진행되며, 제1 RF에너지 전달단계(S200)에서 대상체적(Vt) 내에 부분적으로 불균일한 온도분포가 균일하게 분포될 수 있도록 대상체적(Vt)을 서서히 가열하게 된다. 이때 피부(S)층에서 흡수되는 RF에너지는 피부(S)에서의 열손실량보다 작아 표면온도(Tskin)가 낮아지면서 서서히 안정화 단계에 이르게 된다. 제2 RF에너지 전달단계(S200)에서도 표면온도(Tskin)측정단계가 수행되며, 이때 피부(S)의 표면온도(Tskin)가 42도에 이르는 경우 다음 단계를 수행한다.The second RF energy transfer step S200 is a second smaller than the first RF energy transfer step S100 so as to heat the object Vt at a lower temperature rise rate than when the first RF energy transfer step S100 is performed. Delivers RF output The second RF energy transfer step S200 may be performed for a predetermined time by transmitting an RF output of 200 W, and a partial non-uniform temperature distribution may be uniformly distributed within the object Vt in the first RF energy transfer step S200. The target object Vt is gradually heated so as to be heated. At this time, the RF energy absorbed from the skin (S) layer is smaller than the amount of heat loss in the skin (S), the surface temperature (Tskin) is lowered and gradually reaches the stabilization stage. The surface temperature Tskin measurement step is also performed in the second RF energy transfer step S200. If the surface temperature Tskin of the skin S reaches 42 degrees, the next step is performed.
냉각단계(S400)는 피부(S)의 표면온도(Tskin)가 냉각필요온도(T3) 이상이 되는 경우 피부(S) 표면을 냉각하여 피부(S)손상을 방지할 수 있도록 수행된다. 피부(S)는 약 50도부터 세포의 파괴가 일어나므로, 이보다 낮은 48도를 유지할 수 있도록 수행된다. 실험결과 지방층과 피부(S)의 온도 차이는 최소 3도 이상이므로, 피부(S)를 냉각하더라도 지방층을 지방세포치료온도(T2)인 45도 이하로 낮아지는 것을 방지하기 위함이다. 또한 이를 위하여 냉각단계(S400)는 최대 5분까지만 수행되도록 구성될 수 있다. 그리고 냉각단계(S400)는 냉각필요온도(T3) 이하가 되는 경우 냉각을 중단한다. The cooling step S400 is performed to cool the skin S surface to prevent damage to the skin S when the surface temperature Tskin of the skin S becomes higher than the required cooling temperature T3. The skin (S) is performed to maintain the lower 48 degrees because the destruction of the cell occurs from about 50 degrees. As a result of the experiment, the temperature difference between the fat layer and the skin (S) is at least 3 degrees, so that even if the skin (S) is cooled, the fat layer is prevented from dropping below 45 degrees, the fat cell treatment temperature (T2). In addition, for this purpose, the cooling step S400 may be configured to be performed only up to 5 minutes. And the cooling step (S400) stops cooling when the cooling required temperature (T3) or less.
한편 냉각단계(S400)는 표면온도(Tskin)를 미세하게 조절할 수 있도록 공랭식으로 구성될 수 있다.Meanwhile, the cooling step S400 may be configured by air cooling to finely adjust the surface temperature Tskin.
제3 RF에너지 전달단계(S300)는 대상체적(Vt)의 온도(Tfat)가 일정하게 유지될 수 있도록 대상체적(Vt)의 열흡수 및 열손실에 상응하는 RF에너지를 전달하여 온도를 유지할 수 있도록 수행된다. 이때 100W의 RF출력을 전달하며, 피부(S) 표면온도(Tskin)는 대략 42도, 대상체적(Vt)은 45℃를 유지할 수 있으며, 약 10분 지속하여 대상체적(Vt) 내의 광범위하게 분포하는 다수의 지방세포를 치료할 수 있게 된다. 한편 지방세포치표온도(T2)를 45℃를 예를 들어 설명하였으나, 이는 일 예일 뿐 44℃ 내지 46℃의 범위 내인 경우에도 근사한 효과를 발휘할 수 있다.The third RF energy transfer step S300 may maintain the temperature by transferring RF energy corresponding to heat absorption and heat loss of the target object Vt so that the temperature Tfat of the target object Vt is kept constant. To be performed. At this time, the RF output of 100W is transmitted, the skin temperature (S) surface temperature (Tskin) can be maintained at about 42 degrees, the target object (Vt) can be maintained at 45 ℃, and lasts about 10 minutes to be widely distributed within the subject (Vt) Many fat cells can be treated. On the other hand, the fat cell surface temperature (T2) has been described with an example of 45 ℃, this is only one example can exhibit an approximate effect even in the range of 44 ℃ to 46 ℃.
이상에서 설명한 지방세포 치료용 RF에너지 전달장치 및 지방세포 치료를 위한 RF에너지 전달방법은 대상체적(Vt)이 다른 온도상승률로 온도가 증가할 수 있도록 2단계 이상의 온도상승구간으로 구성되어 신속하게 온도를 상승시킬 수 있고, 이때 피부(S)의 손상을 방지하기 위한 냉각이 수행된다. 따라서 지방세포의 치료효과는 유지하면서 전체소요시간을 단축시킬 수 있는 효과가 있다.The RF energy delivery device for adipocyte therapy and the RF energy delivery method for adipocyte therapy described above are composed of two or more stages of temperature rise so that the temperature can be increased at different temperatures. May be raised, and cooling is performed to prevent damage to the skin (S). Therefore, there is an effect that can shorten the overall time while maintaining the therapeutic effect of fat cells.

Claims (20)

  1. RF에너지를 발생시키도록 구성된 RF제너레이터;An RF generator configured to generate RF energy;
    체내에 위치하는 대상체적에 상기 RF에너지를 전달할 수 있도록 구성된 전극을 포함하는 어플리케이터; 및An applicator comprising an electrode configured to deliver the RF energy to an object located within the body; And
    상기 대상체적에 RF에너지 전달 시 복수의 온도상승구간으로 구분되어 치료온도에 도달할 수 있도록 각 온도상승구간별로 전달되는 RF에너지의 크기를 상이하게 제어하는 제어부를 포함하는 RF에너지 전달장치. RF energy delivery device comprising a control unit for controlling the size of the RF energy delivered to each temperature rise section to reach the treatment temperature is divided into a plurality of temperature rise section when the RF energy to the target object.
  2. 제1 항에 있어서,According to claim 1,
    상기 복수의 온도상승구간은 상기 대상체적의 온도를 상기 치료온도에 인접한 기준온도까지 신속하게 상승시키는 제1 온도상승구간; 및The plurality of temperature rise sections may include a first temperature rise section for rapidly increasing the temperature of the object to a reference temperature adjacent to the treatment temperature; And
    상기 대상체적의 온도를 상기 기준온도로부터 상기 치료온도까지 상승시키는 제2 온도상승구간을 포함하여 구성되는 것을 특징으로 하는 RF에너지 전달장치.And a second temperature rise section for raising the temperature of the object from the reference temperature to the treatment temperature.
  3. 제2 항에 있어서,The method of claim 2,
    상기 제1 온도상승구간 동안 전달되는 제1 RF에너지는 상기 대상체적의 온도를 신속하게 상승시킬 수 있도록 제2 온도상승구간 동안 전달되는 제2 RF에너지보다 큰 것을 특징으로 하는 RF에너지 전달장치.The first RF energy delivered during the first temperature rise section is greater than the second RF energy delivered during the second temperature rise section to quickly increase the temperature of the object.
  4. 제3 항에 있어서,The method of claim 3, wherein
    상기 복수의 온도상승구간은,The plurality of temperature rise section,
    상기 제2 온도상승구간 이후 상기 대상체적이 상기 치료온도로 소정시간 유지되는 온도유지구간을 더 포함하며,After the second temperature rise section further comprises a temperature maintenance section in which the subject is maintained at the treatment temperature for a predetermined time,
    상기 온도유지구간에는 상기 제1 및 제2 온도상승구간에 전달되는 상기 제1 및 제2 RF에너지보다 작은 제3 RF에너지를 전달되는 것을 특징으로 하는 RF에너지 전달장치.And a third RF energy which is smaller than the first and second RF energy delivered to the first and second temperature rise sections in the temperature maintenance section.
  5. 제4 항에 있어서,The method of claim 4, wherein
    상기 대상체적이 신속하게 상기 치료온도에 도달할 수 있도록 상기 제1 온도상승구간이 상기 제2 온도상승구간보다 오래 지속되는 것을 특징으로 하는 RF에너지 전달장치.And the first temperature rise section lasts longer than the second temperature rise section so that the subject can quickly reach the treatment temperature.
  6. 제5 항에 있어서,The method of claim 5,
    상기 제2 온도상승구간의 지속시간은 상기 제1 온도상승구간의 50% 내지 100%이며,The duration of the second temperature rise section is 50% to 100% of the first temperature rise section,
    상기 온도유지구간의 지속시간은 상기 제1 온도상승구간의 50% 내지 200%인 것을 특징으로 하는 RF에너지 전달장치.RF energy transmission device, characterized in that the duration of the temperature maintenance section is 50% to 200% of the first temperature rise section.
  7. 제4 항에 있어서,The method of claim 4, wherein
    상기 어플리케이터는,The applicator,
    피부의 표면온도를 측정할 수 있도록 구성되는 온도센서; 및 A temperature sensor configured to measure the surface temperature of the skin; And
    상기 피부의 표면을 냉각할 수 있도록 구성되는 냉각부를 더 포함하며,Further comprising a cooling unit configured to cool the surface of the skin,
    상기 제어부는 상기 표면온도가 냉각필요온도 이상이 되는 경우 상기 냉각부를 구동시키도록 제어하는 것을 특징으로 하는 RF에너지 전달장치.And the control unit controls to drive the cooling unit when the surface temperature becomes higher than the required cooling temperature.
  8. 제7 항에 있어서,The method of claim 7, wherein
    상기 냉각필요온도는 상기 온도상승구간에서 상기 피부의 손상을 방지할 수 있도록 48℃ 내지 50℃ 인 것을 특징으로 하는 RF에너지 전달장치.The cooling required temperature is RF energy delivery device, characterized in that 48 ℃ to 50 ℃ to prevent damage to the skin in the temperature rise section.
  9. 제7 항에 있어서,The method of claim 7, wherein
    상기 냉각부는,The cooling unit,
    상기 표면온도가 급격하게 냉각되는 것을 방지할 수 있도록 공랭식으로 구성되는 것을 특징으로 하는 RF에너지 전달장치.RF energy delivery device, characterized in that configured to be air-cooled to prevent the surface temperature is rapidly cooled.
  10. 제9 항에 있어서,The method of claim 9,
    상기 제어부는,The control unit,
    상기 냉각부의 구동시 상기 대상체적의 온도가 하강하지 않도록 1회 구동시 5분 이내의 시간동안 구동시키는 것을 특징으로 하는 RF에너지 전달장치.RF energy transmission device characterized in that for driving for a time within 5 minutes when driving once so that the temperature of the object is not lowered during the driving of the cooling unit.
  11. 제4 항에 있어서,The method of claim 4, wherein
    상기 제어부는,The control unit,
    상기 제1 RF에너지의 크기는 상기 제1 온도상승구간에서 상기 대상체적이 상기 기준온도에 신속하게 도달할 수 있도록 상기 제3 RF에너지 크기의 3배 내지 5배가 되도록 제어하는 것을 특징으로 하는 RF에너지 전달장치.The magnitude of the first RF energy is controlled to be three to five times the magnitude of the third RF energy so that the subject can quickly reach the reference temperature in the first temperature rise section. Delivery device.
  12. 제4 항에 있어서,The method of claim 4, wherein
    상기 제1 RF에너지는 300W 내지 500W,The first RF energy is 300W to 500W,
    상기 제2 RF에너지는 100W 내지 300W, 및The second RF energy is 100W to 300W, and
    상기 제3 RF에너지는 50W 내지 150W인 것을 특징으로 하는 RF에너지 전달장치.The third RF energy RF energy delivery device, characterized in that 50W to 150W.
  13. 제4 항에 있어서,The method of claim 4, wherein
    상기 제1 온도상승구간은 5분 내지 15분,The first temperature rise section is 5 minutes to 15 minutes,
    상기 제2 온도상승구간은 5분 내지 10분, 및The second temperature rise section is 5 minutes to 10 minutes, and
    상기 온도유지구간은 5분 내지 15분 지속되는 것을 특징으로 하는 RF에너지 전달장치.The temperature maintenance section is an RF energy delivery device, characterized in that lasting 5 to 15 minutes.
  14. 제4 항에 있어서,The method of claim 4, wherein
    상기 대상체적은 지방세포를 포함하며,The subject includes fat cells,
    상기 치료온도는 상기 지방세포가 변성되는 온도이며,The treatment temperature is the temperature at which the fat cells are denatured,
    상기 지방세포가 변성되는 온도는 44℃ 내지 46℃인 것을 특징으로 하는 RF에너지 전달장치.The temperature at which the fat cells are denatured is an RF energy delivery device, characterized in that 44 ℃ to 46 ℃.
  15. 제14 항에 있어서,The method of claim 14,
    상기 기준온도는 40℃ 내지 44℃인 것을 특징으로 하는 RF에너지 전달장치.The reference temperature is an RF energy delivery device, characterized in that 40 ℃ to 44 ℃.
  16. 제4 항에 있어서,The method of claim 4, wherein
    상기 제어부는,The control unit,
    상기 제1 온도상승구간동안 상기 대상체적이 가장 큰 온도상승률로 가열될 수 있도록 상기 제1 RF에너지 및 상기 제2 RF에너지를 제어하는 것을 특징으로 하는 RF에너지 전달장치.And controlling the first RF energy and the second RF energy so that the object can be heated to the largest temperature rise rate during the first temperature rise period.
  17. 대상체적을 제1 온도상승구간 동안 제1 RF출력을 전달하여 가열하는 제1 RF에너지 전달단계;A first RF energy transfer step of heating the object by transmitting a first RF output during the first temperature rise section;
    상기 제1 온도상승구간보다 낮은 온도상승률로 온도상승이 이루어질 수 있도록 제2 온도상승구간 동안 상기 제1 RF출력보다 작은 제2 RF출력을 전달하는 제2 RF에너지 전달단계; A second RF energy transfer step of transferring a second RF output smaller than the first RF output during the second temperature rise section so that the temperature rise can be performed at a temperature rise rate lower than the first temperature rise section;
    상기 대상체적이 치료되는 온도인 치료온도로 유지될 수 있도록 상기 제2 RF출력보다 작은 제3 RF출력을 전달하는 제3 RF에너지 전달단계를 포함하는 RF에너지 전달방법.And a third RF energy delivery step of delivering a third RF output smaller than the second RF output so that the subject can be maintained at a treatment temperature which is the temperature at which the object is being treated.
  18. 제17 항에 있어서,The method of claim 17,
    상기 대상체적이 치료온도에 인접한 기준온도에 도달하는 경우, 상기 제1 RF에너지 전달단계는 종료되고 상기 제2 RF에너지 전달단계가 수행되며, When the subject reaches a reference temperature adjacent to the treatment temperature, the first RF energy delivery step is terminated and the second RF energy delivery step is performed,
    상기 대상체적이 치료온도에 도달하는 경우 상기 제2 RF에너지 전달단계는 종료되고 제3 RF에너지 전달단계가 수행되며,When the subject reaches the treatment temperature, the second RF energy delivery step is terminated and a third RF energy delivery step is performed,
    상기 기준온도는 상기 치료온도보다 낮은 것을 특징으로 하는 RF에너지 전달방법.The reference temperature is RF energy delivery method, characterized in that lower than the treatment temperature.
  19. 제18 항에 있어서,The method of claim 18,
    상기 제1 RF에너지 전달단계 및 상기 제2 RF전달단계 수행 중, During the first RF energy transfer step and the second RF transfer step,
    상기 대상체적에 인접하는 피부의 표면온도가 냉각필요온도에 해당하는 경우 상기 피부를 냉각하는 냉각단계가 수행되는 것을 특징으로 하는 RF에너지 전달방법.And a cooling step of cooling the skin is performed when the surface temperature of the skin adjacent to the object corresponds to the required cooling temperature.
  20. 제17 항에 있어서,The method of claim 17,
    상기 제2 온도상승구간의 지속시간은 상기 제1 온도상승구간의 50% 내지 100%이며,The duration of the second temperature rise section is 50% to 100% of the first temperature rise section,
    상기 온도유지구간의 지속시간은 상기 제1 온도상승구간의 80% 내지 200%인 것을 특징으로 하는 RF에너지 전달방법.The duration of the temperature maintenance section is RF energy transfer method, characterized in that 80% to 200% of the first temperature rise section.
PCT/KR2017/007646 2016-07-22 2017-07-17 Rf energy transmitter and rf energy transmission method WO2018016819A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0093580 2016-07-22
KR1020160093580A KR20180010825A (en) 2016-07-22 2016-07-22 The apparatus for delivering radio-frequency energy and an method for that

Publications (1)

Publication Number Publication Date
WO2018016819A1 true WO2018016819A1 (en) 2018-01-25

Family

ID=60992302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/007646 WO2018016819A1 (en) 2016-07-22 2017-07-17 Rf energy transmitter and rf energy transmission method

Country Status (2)

Country Link
KR (1) KR20180010825A (en)
WO (1) WO2018016819A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD971415S1 (en) 2019-12-30 2022-11-29 Cynosure, Llc Flexible applicator

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652513B2 (en) * 1995-06-07 2003-11-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
KR20110066327A (en) * 2009-12-11 2011-06-17 (주)에너지플러스 Adjustable system for treatment wave and temperature of radio frequency simulator
KR20120090007A (en) * 2009-02-25 2012-08-16 프리마바 메디컬, 아이엔씨. Devices and methods for percutaneous energy delivery
KR101246980B1 (en) * 2005-07-26 2013-03-25 시네론 메디컬 리미티드 Method and apparatus for treatment of skin using rf and ultrasound energies
KR101533403B1 (en) * 2012-11-06 2015-07-03 한국과학기술원 Iontophoresis patch

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652513B2 (en) * 1995-06-07 2003-11-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
KR101246980B1 (en) * 2005-07-26 2013-03-25 시네론 메디컬 리미티드 Method and apparatus for treatment of skin using rf and ultrasound energies
KR20120090007A (en) * 2009-02-25 2012-08-16 프리마바 메디컬, 아이엔씨. Devices and methods for percutaneous energy delivery
KR20110066327A (en) * 2009-12-11 2011-06-17 (주)에너지플러스 Adjustable system for treatment wave and temperature of radio frequency simulator
KR101533403B1 (en) * 2012-11-06 2015-07-03 한국과학기술원 Iontophoresis patch

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD971415S1 (en) 2019-12-30 2022-11-29 Cynosure, Llc Flexible applicator
USD1014763S1 (en) 2019-12-30 2024-02-13 Cynosure, Llc Flexible applicator

Also Published As

Publication number Publication date
KR20180010825A (en) 2018-01-31

Similar Documents

Publication Publication Date Title
JP7142581B2 (en) Non-Invasive Uniform and Non-Uniform RF Systems
US11154349B2 (en) Vaginal remodeling device and methods
US20200352633A1 (en) Non-invasive, uniform and non-uniform rf methods and systems related applications
WO2012138056A1 (en) Apparatus for removing fat having excellent effects in removing fatty tissue, and method for removing fat using same
US20190133673A1 (en) Non-Invasive, Uniform and Non-Uniform RF Methods and Systems Related Applications
WO2018016929A1 (en) Therapeutic rf energy transmitter and method for controlling same
WO2011115451A2 (en) Phototherapeutic apparatus
WO2018016819A1 (en) Rf energy transmitter and rf energy transmission method
WO2023077831A1 (en) Therapeutic instrument control circuit and therapeutic instrument
WO2020138701A1 (en) Smart electronic moxibustion treatment system
KR20190011797A (en) The apparatus for delivering radio-frequency energy and an method for that
WO2023113170A1 (en) High-frequency energy transfer device capable of precise temperature tracking
EP3346937B1 (en) Apparatus with handle assembly for radio frequency therapy
CN101766503A (en) Microwave electrotome two-purpose therapeutic instrument
WO2014129690A1 (en) Device for alleviating pain of temporomandibular joint
WO2019017532A1 (en) Treatment system for acne disease and operation method thereof
JP2003235865A (en) Thermal type treatment implement and treatment system using the same
CN206700382U (en) A kind of medication applicator device
CN105641812B (en) Skin disease Rehabilitation Nursing machine
WO2012161388A1 (en) Handpiece for skin care device having cooling function
CN110507413A (en) A kind of microwave therapy apparatus that ablation effective heating field is controllable
KR20220013699A (en) Apparatus for improving lax vagina syndrome
CN214596831U (en) Red light moxa-moxibustion treatment of gynaecology instrument
CN1035861C (en) Tissue cauterization hot therapeutic apparatus
CN210019689U (en) Special heating device for laparoscopic surgery

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17831292

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17831292

Country of ref document: EP

Kind code of ref document: A1