WO2017203784A1 - Résonateur d'irm rehaussée par l'effet overhauser, et procédé de mesure d'irm rehaussée par l'effet overhauser - Google Patents

Résonateur d'irm rehaussée par l'effet overhauser, et procédé de mesure d'irm rehaussée par l'effet overhauser Download PDF

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Publication number
WO2017203784A1
WO2017203784A1 PCT/JP2017/008188 JP2017008188W WO2017203784A1 WO 2017203784 A1 WO2017203784 A1 WO 2017203784A1 JP 2017008188 W JP2017008188 W JP 2017008188W WO 2017203784 A1 WO2017203784 A1 WO 2017203784A1
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WIPO (PCT)
Prior art keywords
loop
sample
resonator
gap
power receiving
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PCT/JP2017/008188
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English (en)
Japanese (ja)
Inventor
和洋 市川
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国立大学法人九州大学
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Publication of WO2017203784A1 publication Critical patent/WO2017203784A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/12—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using double resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals

Definitions

  • the present invention relates to an overhauser effect MRI used for obtaining an image such as a functional image or a morphological image of a sample using electron spin resonance (ESR) and nuclear magnetic resonance (NMR).
  • ESR electron spin resonance
  • NMR nuclear magnetic resonance
  • the present invention relates to a resonator for use and an overhauser effect MRI measurement method using the same.
  • OMRI Overhauser effect MRI
  • the applicant has developed a measuring apparatus capable of performing OMRI measurement, for example, as described in Patent Documents 1 to 3.
  • ESR and NMR are excited using a cylindrical RF coil (resonator).
  • a local magnetic field is required for radical excitation, when such a cylindrical RF coil is used, the efficiency decreases due to the generation of an electric field, and the sample in the RF coil is heated. There is.
  • JP 2006-204551 A Japanese Patent No. 5252444 Japanese Patent No. 5574386
  • FIG. 9 is a plan view of a conventional loop gap resonator
  • FIG. 10 is an explanatory diagram showing a state where power is fed to the loop gap resonator of FIG.
  • FIGS. 9 and 10 when the sample S is set in the loop portion 101 of the loop gap resonator 100 and an electromagnetic wave is fed from the feeding antenna 103, the electric field concentrates in the gap portion 102, and the loop portion 101 A uniform magnetic field is generated.
  • the output of the electromagnetic wave to be fed is about 10 mW in the ESR application, it is several W to several tens W in the OMRI application, so nonspecific heat absorption to the sample at the time of electromagnetic wave feeding is inevitable. There is a problem that the sample is heated.
  • an object of the present invention is to provide an OMRI resonator that suppresses nonspecific heat absorption to a sample during electromagnetic wave feeding and an OMRI measurement method using the resonator.
  • the resonator for OMRI is a loop gap portion composed of an NMR coil in which a sample is arranged inside, a loop portion in which the sample is set, and a gap portion that interrupts the loop portion, and at least the loop portion.
  • a loop gap portion disposed in the NMR coil and a power receiving portion to which electromagnetic waves are fed by the feeding antenna, and is connected to the gap portion so as not to overlap the loop portion on which the sample is set.
  • the OMRI measurement method of the present invention is a loop gap portion comprising an NMR coil in which a sample is disposed inside, a loop portion in which the sample is set, and a gap portion that interrupts the loop portion, and at least the loop
  • the part is a loop gap part arranged in the NMR coil and a power receiving part to which electromagnetic waves are fed by the feeding antenna, and is connected to the gap part so as not to overlap the loop part where the sample is set.
  • MRI resonator having a loop gap resonator having a power receiving unit for receiving an electromagnetic wave fed by an antenna so as not to be directly radiated to a sample set in the loop unit
  • an electron scan is applied to the sample.
  • emissions resonance or after that caused the electron spin resonance in the sample, sample to cause a nuclear magnetic resonance by NMR coil electron spin - and measuring the nuclear spin interactions phenomenon.
  • the power receiving unit is connected to the gap so as not to overlap the loop unit in which the sample is set, an electromagnetic wave of several W to several tens W is fed to the power receiving unit by the feeding antenna.
  • this electromagnetic wave is not directly emitted to the sample set in the loop portion, nonspecific heat absorption into the sample is suppressed, and the sample can be prevented from being heated.
  • the resonance frequency can be adjusted by the number of loops of one or both of the loop unit and the power receiving unit.
  • the loop gap resonator may be configured such that the power receiving unit is disposed in the NMR coil, but it is desirable that the power receiving unit is disposed outside the NMR coil. In the case where the power receiving unit is arranged outside the NMR coil, it is possible to minimize the influence on the sample in the NMR coil when an electromagnetic wave of several W to several tens W is fed to the power receiving unit by the power feeding antenna. .
  • a loop gap part composed of an NMR coil in which the sample is arranged inside, a loop part in which the sample is set, and a gap part that interrupts the loop part, and at least the loop part is arranged in the NMR coil.
  • a loop gap portion provided and a power receiving portion to which an electromagnetic wave is fed by a feeding antenna.
  • an electromagnetic wave fed by the feeding antenna is According to the OMRI resonator having a loop gap resonator having a power receiving portion that receives power so as not to be directly radiated to a sample set in the loop portion and causes electromagnetic resonance in the loop gap portion. Since non-specific heat absorption into the sample is suppressed and the sample can be prevented from being heated, the sample can be prevented from being damaged by heat. Spin - it is possible to measure the nuclear spin interactions phenomenon.
  • the resonance frequency can be adjusted by the number of loops of one or both of the loop unit and the power receiving unit. This makes it possible to easily manufacture a loop gap resonator corresponding to a target resonance frequency.
  • FIG. 1 is a schematic configuration diagram of an OMRI resonator according to a first embodiment of the present invention
  • FIG. 2 is a plan view of the loop gap resonator of FIG. 1
  • FIG. 3 is a feed antenna with respect to the loop gap resonator of FIG. It is explanatory drawing which shows a mode that electric power feeding is performed.
  • the OMRI resonator 1A includes an NMR coil 2 in which a sample S is disposed, and a loop gap resonator 3A disposed in the NMR coil 2.
  • the loop gap resonator 3A receives the electromagnetic wave fed by the loop gap portion 4 including the loop portion 4A in which the sample S is set and the gap portion 4B that interrupts the loop portion 4A and the feed antenna 6,
  • the loop gap portion 4 includes a power receiving portion 5 that causes electromagnetic field resonance.
  • the loop gap part 4 and the power receiving part 5 of the loop gap resonator 3A are arranged side by side along the central axis 2X of the cylindrical NMR coil 2. That is, the central axis 4X of the loop of the loop part 4A of the loop gap part 4 and the central axis 5X of the power receiving part 5 are arranged so as to be orthogonal to the central axis 2X of the NMR coil 2.
  • the power receiving unit 5 is connected to the gap 4B so as not to overlap the loop 4A.
  • the NMR coil 2 is not limited to a cylindrical shape.
  • the sample S arranged inside the NMR coil 2 was placed on the loop portion 4A of the loop gap resonator 3A.
  • the electromagnetic wave E1 of several W to several tens of W is fed to the power receiving unit 5 by the power feeding antenna 6, the electric field concentrates on the gap 4 and a uniform magnetic field E2 is generated in the loop 4A.
  • the NMR coil 2 causes the sample S to have a nucleus. Magnetic resonance is caused to measure the electron spin-nuclear spin interaction phenomenon.
  • the power receiving unit 5 is connected to the gap unit 4B so as not to overlap the loop unit 4A in which the sample S is set. Even if an electromagnetic wave of several watts to several tens of watts is fed by 6, this electromagnetic wave is not directly radiated to the sample S set in the loop portion 4 A, and nonspecific heat absorption into the sample S is suppressed, S can be prevented from being heated. Therefore, the electron spin-nucleus spin interaction phenomenon can be measured without damaging the sample S with heat.
  • FIG. 4 is a schematic configuration diagram of an OMRI resonator according to the second embodiment of the present invention.
  • the same components as those in the above-described OMRI resonator 1A are denoted by the same reference numerals, and detailed description thereof is omitted.
  • the loop portion 7A of the loop gap portion 7 of the loop gap resonator 3B disposed in the NMR coil 2 is looped a plurality of times. It has become.
  • the number of loops of the loop portion 7A is set according to the set resonance frequency.
  • the loop gap section 7 and the power receiving section 5 are arranged side by side along the central axis 2X of the NMR coil 2, and the central axis 7X of the loop of the loop section 7A and the central axis 5X of the power receiving section 5 are aligned with the central axis 2X of the NMR coil 2. It arrange
  • the power receiving unit 5 is connected to the gap unit 4 so as not to overlap the loop unit 7A.
  • the power receiving unit 5 with the loop portion 7A of the loop gap resonator 3B placed on the sample S arranged inside the NMR coil 2 is used. Electromagnetic waves of several tens to several tens of watts are fed to the power supply antenna 6 to cause electromagnetic resonance in the loop gap 7, thereby causing electron spin resonance in the sample S or electrons in the sample S. After spin resonance is generated, nuclear magnetic resonance is caused in the sample S by the NMR coil 2 to measure the electron spin-nucleus spin interaction phenomenon.
  • the power receiving unit 5 may be configured to loop a plurality of times. That is, it is possible to adopt a configuration in which either one or both of the loop portion 7A and the power receiving unit 5 are looped a plurality of times in accordance with the resonance frequency to be adjusted.
  • the OMRI resonator 1B in the present embodiment it is possible to amplify the magnetic field strength of the loop portion 7A by configuring one or both of the loop portion 7A and the power receiving portion 5 a plurality of times. Without changing the endothermic amount of the sample S, it is possible to cause electromagnetic field resonance efficiently.
  • FIG. 5 is a schematic configuration diagram of an OMRI resonator according to a third embodiment of the present invention.
  • the same components as those in the above-described OMRI resonator 1A are denoted by the same reference numerals, and detailed description thereof is omitted.
  • the loop portion 4A of the loop gap resonator 3A of the OMRI resonator 1A is disposed in the NMR coil 2 to receive power.
  • the portion 5 is arranged outside the NMR coil 2.
  • the central axis 4X of the loop of the loop part 4A of the loop gap part 4 is arranged in parallel with the central axis 2X of the NMR coil 2.
  • the gap portion 4B may be disposed either inside or outside the NMR coil 2.
  • the NMR coil 2 is placed in the loop portion 4 ⁇ / b> A disposed inside the NMR coil 2 while the sample S disposed inside the NMR coil 2 is placed. Electromagnetic resonance of several tens to several tens of watts is fed to the power receiving unit 5 disposed outside the power receiving antenna 5 and causes electromagnetic resonance in the loop gap 4, thereby causing electron spin resonance in the sample S. At the same time or after causing electron spin resonance in the sample S, the NMR coil 2 causes nuclear magnetic resonance in the sample S to measure the electron spin-nucleus spin interaction phenomenon.
  • the power receiving unit 5 is connected to the gap unit 4B so as not to overlap the loop unit 4A in which the sample S is set, similarly to the OMRI resonators 1A and 1B described above. Therefore, even if an electromagnetic wave of several W to several tens of W is fed to the power receiving unit 5 by the feeding antenna 6, the electromagnetic wave is not directly radiated to the sample S set in the loop unit 4A.
  • the power receiving unit 5 since the power receiving unit 5 is disposed outside the NMR coil 2, the influence on the sample S in the NMR coil 2 is minimized when an electromagnetic wave of several W to several tens W is fed to the power receiving unit 5 by the power feeding antenna 6. In addition, it is possible to protect the sample from heat.
  • the sample S can be measured not on the loop part 4A but on the loop part 4A.
  • the loop portion 5 of the loop gap resonator 3 ⁇ / b> A disposed in the NMR coil 2 may be disposed outside the NMR coil 2.
  • FIG. 6 is a schematic configuration diagram of an OMRI resonator according to a fourth embodiment of the present invention.
  • the same components as those in the above-described OMRI resonator 1B are denoted by the same reference numerals, and detailed description thereof is omitted.
  • the loop portion 7A of the loop gap resonator 3B of the OMRI resonator 1B is disposed in the NMR coil 2 to receive power.
  • the portion 5 is arranged outside the NMR coil 2.
  • the central axis 7X of the loop of the loop portion 7A is arranged in parallel with the central axis 2X of the NMR coil.
  • the gap portion 4B may be disposed either inside or outside the NMR coil 2.
  • the sample S arranged inside the NMR coil 2 is placed in the loop of the loop part 7A arranged in the NMR coil 2, Electromagnetic spin resonance is applied to the sample S by feeding electromagnetic waves of several tens to several tens of watts to the power receiving unit 5 disposed outside the NMR coil 2 by the power feeding antenna 6 and causing electromagnetic resonance in the loop gap unit 7.
  • the NMR coil 2 causes nuclear magnetic resonance in the sample S to measure the electron spin-nucleus spin interaction phenomenon.
  • the power receiving unit 5 has the gap portion 4B so as not to overlap the loop portion 7A in which the sample S is set, similarly to the OMRI resonators 1A, 1B, and 1C described above. Therefore, even when an electromagnetic wave of several W to several tens of W is fed to the power receiving unit 5 by the feeding antenna 6, the electromagnetic wave is not directly radiated to the sample S set in the loop unit 7A. However, since the power receiving unit 5 is disposed outside the NMR coil 2, an influence on the sample S in the NMR coil 2 when an electromagnetic wave of several W to several tens W is fed to the power receiving unit 5 by the power feeding antenna 6. And the sample can be protected from heat.
  • the sample S can be measured not on the loop portion 7A but on the loop portion 7A.
  • the loop portion 7 ⁇ / b> A of the loop gap resonator 3 ⁇ / b> B disposed in the NMR coil 2 may be disposed outside the NMR coil 2.
  • FIG. 7 shows an example in which a plurality of loop portions 4A and 7A of the loop gap portions 4 and 7 are connected in series.
  • FIG. 8 shows an example in which a plurality of loop portions 4A and 7A of the loop gap portions 4 and 7 are connected in parallel.
  • the OMRI resonator and the OMRI measurement method of the present invention are a resonator and a measurement method for obtaining an image such as a functional image or a morphological image of a sample using electron spin resonance (ESR) and nuclear magnetic resonance (NMR). It is useful, and is particularly suitable as an OMRI resonator that suppresses nonspecific heat absorption to a sample during electromagnetic wave feeding and an OMRI measurement method using the resonator.
  • ESR electron spin resonance
  • NMR nuclear magnetic resonance

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Abstract

La présente invention concerne un résonateur d'IRM rehaussée par l'effet Overhauser dont l'absorption de chaleur non spécifique par un échantillon pendant l'alimentation en ondes électromagnétiques est supprimée, et un procédé de mesure d'IRM rehaussée par l'effet Overhauser utilisant ce résonateur. Le résonateur d'IRM rehaussée par l'effet Overhauser 1A comporte : une bobine d'IRM 2 à l'intérieur de laquelle est placé un échantillon S ; et un résonateur à espace-boucle 3A ayant une partie espace-boucle 4 conçue à partir d'une partie boucle 4A dans laquelle l'échantillon S est placé et une partie espace 4B interrompant la partie boucle 4A, la partie boucle 4A de la partie espace-boucle 4 étant disposée dans la bobine d'IRM 2, et une partie réception d'énergie 5 recevant des ondes électromagnétiques fournies par une antenne d'alimentation 6, la partie réception d'énergie 5 étant reliée à la partie espace 4B de façon à ne pas se superposer à la partie boucle 4A dans laquelle l'échantillon S est placé, l'énergie étant reçue de telle sorte que les ondes électromagnétiques fournies par l'antenne d'alimentation 6 ne soient pas directement envoyées vers l'échantillon S placé dans la partie boucle 4A, et la partie réception d'énergie 5 provoquant la résonance de champ électromagnétique dans la partie espace-boucle 4.
PCT/JP2017/008188 2016-05-26 2017-03-01 Résonateur d'irm rehaussée par l'effet overhauser, et procédé de mesure d'irm rehaussée par l'effet overhauser WO2017203784A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6446637A (en) * 1987-08-14 1989-02-21 Jeol Ltd Flat spiral spring type resonator
JPH07270510A (ja) * 1994-03-31 1995-10-20 Yamagata Pref Gov Ｅｓｒ，ｎｍｒ共用プローブ
JPH10328161A (ja) * 1997-03-26 1998-12-15 Nycomed Imaging As 磁気共鳴検査方法及びその方法に用いるｍｒイメージング剤
JP2008002933A (ja) * 2006-06-22 2008-01-10 Jeol Ltd ループギャップ共振器
JP2008545148A (ja) * 2005-07-05 2008-12-11 コミサリア ア レネルジィ アトミーク 改善された充填率及びｒｆ磁場振幅を用いる高分解能ｎｍｒ分光及び／又はイメージング装置及び方法。

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6446637A (en) * 1987-08-14 1989-02-21 Jeol Ltd Flat spiral spring type resonator
JPH07270510A (ja) * 1994-03-31 1995-10-20 Yamagata Pref Gov Ｅｓｒ，ｎｍｒ共用プローブ
JPH10328161A (ja) * 1997-03-26 1998-12-15 Nycomed Imaging As 磁気共鳴検査方法及びその方法に用いるｍｒイメージング剤
JP2008545148A (ja) * 2005-07-05 2008-12-11 コミサリア ア レネルジィ アトミーク 改善された充填率及びｒｆ磁場振幅を用いる高分解能ｎｍｒ分光及び／又はイメージング装置及び方法。
JP2008002933A (ja) * 2006-06-22 2008-01-10 Jeol Ltd ループギャップ共振器

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