WO2017193458A1

WO2017193458A1 - Organosilicone modified acrylic polyester potassium salt and preparation method and use in prevention and treatment of cancer

Info

Publication number: WO2017193458A1
Application number: PCT/CN2016/087162
Authority: WO
Inventors: 樊惠昌; 谭继明
Original assignee: 上海惠昌化工厂
Priority date: 2016-05-09
Filing date: 2016-06-24
Publication date: 2017-11-16
Also published as: CN105837734A

Abstract

Disclosed are an organosilicone modified acrylic polyester potassium salt and a preparation method therefor. The organosilicone modified acrylic polyester potassium salt is prepared from an acrylic acid or esters thereof, acrylic organosilicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water, wherein the mass ratio of the acrylic acid or esters thereof to acrylic organosilicone to potassium persulfate to isopropanol to potassium hydroxide to deionized water is 15.0 - 20.0 : 0.7 - 2.0 : 0.3 - 1.0 : 6.0 - 10.0 : 8.0 - 15.0 : 52.0 - 70.0. The organosilicone modified acrylic polyester potassium salt can be used in the preparation of drugs or health care products for treating or preventing cancers, and can control the heavy metal toxicity, and thus can quickly prevent and treat cancers and has a health care effect.

Description

Silicone modified acrylic polyester potassium salt, preparation method thereof and anticancer and cancer treatment use

Technical field

The invention belongs to the field of biomedicine and relates to a health care product, in particular to a silicone modified acrylic polyester potassium salt, a preparation method thereof and a cancer prevention and cancer treatment application.

Background technique:

(1) A new type of sub-S - child (life base)

S is a flexible base.

S is formed by the accumulation of photons in the nucleus (especially the H nucleus), providing energy to actuate the protons and then promoting the atomic reaction and then returning to the reduced photons, so it is a viable life-type basis.

Photons are most likely to enter the H nucleus (H nucleus has only one electron cloud and one electron), so it is most easy to generate S in the H nucleus.

Photons are also easy to enter C, O, and N nucleuses (there are only two layers of electron clouds in the nucleus, and there are few electrons), so it is easy to promote nuclear, and it can also generate S to further promote nuclear.

The main factors affecting human survival are as follows:

Nature's biological origin: pure H ₂ O, CO ₂ state, photon radiation H particles generate protons → mobilize H protons → actuate H electrons → H ₂ O microelectrolysis → bind with CO ₂ → form natural primary organic carbohydrates → later Gradually produce plants → animals, humans.

This is the origin of the biological origin of nature, photonuclear radiation is the primary source of physical chemistry of natural organisms, S is a special generation of base!

Human life genetic elements: metabolism. The organic matter in the human body loses the child due to the lapse of time, and loses the flexibility. The space-like organic matter is rich in raw seeds due to the photonucleus, so the human body can be replaced by the same kind of substance, and the flexibility is regulated.

This is where C, H, O, and N can form an organic chemical life, where S is the life base.

child. Special note: photons (mass 0) are not charged but can be attached with micro-charges. Therefore, the accumulation of photons into the nucleus can form a cumulative micro-charge of the living beings to promote the nuclear function, but how much micro-energy is accumulated by the S-subjects needs to be verified by humans.

(B), comprehensive chemistry (a set of new theory of life genes)

This theory proposes the principles of organic chemistry, inorganic chemistry, biochemistry, nuclear physics and chemistry to finally explore the fundamental basis of life genes (atoms, protons, electrons, neutrons, children, photons). In order to achieve scientific control and effective results.

First, comprehensive chemistry (exploration of human genes):

Photon nuclear action → childbirth effect → atomic Edwardian effect → atomic binding → organic chemical reaction → formation of molecular genes.

Second, to control human health: water, electricity, gas, comprehensive chemical and physical balance.

Third, the direction of human drug innovation: the first is based on no side effects or reduce side effects, followed by targeted improvement effect.

Fourth, profound understanding of the serious harm caused by environmental pollution caused by a large amount of energy consumption per day. Humanity should strengthen unity and reunification, and cause common concern and strengthen joint prevention. Really save humanity: prevent the disease before, cure the disease!

(3) The most common gene for cancer in humans - the heavy metal salt of gastric acid

The stomach is the digestive system of the human body. Normal people must eat a lot of animals and plants for a long time. It is the first and most important part of the daily complex chemical reaction of the human body. Therefore, it should be understood that it is very effective and often has the most side effects. This is the reason why human cancer has the highest rate of cancer in cancer.

The stomach is lysed in foods with large acid value (pH ≈1~2) and oxygen-rich state. The main components of normal chemical cleavage should be:

Amino acids (mostly alpha, beta), which are absorbed or excreted by the body's main nutrients;

Organic acids, carbohydrates, salt, and water are needed to be absorbed or excreted by the body;

Carbon dioxide (O combined with pyrolytic activated carbon), detoxification, will be vented.

It is undoubted that the main chemical function of the stomach itself and after the digestion reaction is - carboxyl (-COOH), and the carboxyl group is easily reacted with the metal to form a salt, which is specifically described as follows:

1. Form a negative monovalent salt with potassium and sodium. Small, fine, live, flexible to the human body water, electricity, gas, easy to metabolic excretion;

2, with calcium, iron to form a negative divalent salt, medium, fine, still alive, to provide moderate toughness and provide red blood cells for human bones, but also metabolism, God wants to arrange life for thousands of years;

3, with heavy metals to form high negative salt (≥ 2), large, thick, solid, difficult to metabolic excretion. It is undeniable that the human body must ingest a small amount of heavy metals to toughen teeth, bones, tendons and other health functions, but it should be understood that the heavy metal salt is too solid, and it also lurks certain radiant energy, so once it is ultra-micro sequela Must be fatal.

Cancer is an uncontrollable foreign body protein. At present, it is generally believed that the factors of gastric cancer production are mainly caused by the ingestion of organic amines, nitrites, aromatic compounds, molds and the like. This kind of poison does cause abnormal carcinogenesis of the stomach, but from its chemical point of view, the reaction result is not 100% destructive, and it is not comparable to the side effects of heavy metal salts of gastric acid.

The chemical direction of acid and metal salt is fixed. The salt formed by gastric acid and heavy metal is polycyclic multi-branched salt and large nuclear energy salt. It can quickly destroy the gastric acid digestion function and is not easy to metabolize. Once it is ultra-micro or time-long, it is a cause. There is no doubt that heavy metals enter the stomach. At present, the human ecological environment is due to the huge daily energy consumption of human beings, which also leads to waste gas residue. There are not many days and times. The biggest evil result is that there are unpredictable heavy metals scattered on the ground every day. Animals and plants and water sources absorb – and finally enter the human body in large quantities.

It can be inferred that it is the influence of heavy metals (polycyclic multi-branched salt and large nuclear energy salt) that is the main cause of human gastric cancer, and the heterologous protein gene formed by the stomach also transfers other internal organs of the human body - cancer metastasis - - This type of genetic gene will eventually form. It can be concluded that heavy metal pollution is currently the biggest cause of human injury - now no longer controlled, it will destroy humans for a long time!

The use of comprehensive chemistry discussion to infer the characteristics of gastric acid heavy metal salt genes.

The principle of controlling human health is to ensure the comprehensive chemical and physical balance of water, electricity and gas, so destroying this kind of balance means harming the human body. Obviously, if the human body touches a chemical that is too active or too rigid, it will cause death. This has been confirmed many times by human tragedies. Living: bacteria infection, active organic amines, cyanide salts, etc., it can quickly destroy the reaction of human body catalyzed biological enzymes, resulting in rapid loss of control of human metabolism and death; over the dead: that is heavy metal actives, uncontrollable metabolism, long-term must Killed.

Gastric acid chemical structure:

It can be inferred that the most injurious type of dead plate type is Pb salt and As salt. The compound genes are not only fixed and too high to be metabolized, but also multi-ring and multi-branched are more likely to form unsuitable multiple adverse reaction results.

Discuss inferred heavy metal salt destruction genes and transfer genes:

1. If a branch is a ~COO·chain formed by binding to gastric acid protease, the result is equivalent to bacterial destruction, and it is not easy to metastasize, and gastric cancer can be formed relatively quickly;

2, this type of branch is mostly based on amino acids, can be stagnant in the stomach or transfer absorption, transfer to the intestine, liver, gallbladder, kidney to form the destruction gene, accumulate into cancer;

3, the molecular weight of the branched chain amino acid is small, the flow activity is high, and it is easy to transfer into the blood and the lungs, forming a cancer there;

4, this kind of amino acid salt can be clearly identified as organic amine salt, so once it enters the bloodstream, it can increase several types of white blood cells and is not easy to replace, forming leukemia, which is the rapid increase rate of leukemia in human proximal stage;

5. In terms of structure, arsenic salt seems to be more destructive than lead salt, but it is not. It is known that human metabolism must be released by human beings. In general, photons are not easy to enter the heavy metal core of multi-layer electron cloud to promote nuclear, but Once accumulated, the nuclear radiation will form. C, H, O organic matter is easy to suck and give birth to children, and it is easy to enter the lead nucleus when the body is stuffy for a long time, forming deadly nuclear radiation!

At present, due to the daily energy consumption and lead pollution, the environment is comprehensively judged by chemical physics: lead is the primary pollutant that currently harms human health. Humans must be given special control.

Based on the above theoretical inventions: drugs are essential for human survival. At present, due to the rapid development of society, the world has created a lot of edible drugs, which have made many contributions to the treatment of diseases and save people. It is undeniable. However, the harm caused by many drugs after human consumption Sexual side effects are also growing, and attention should be paid to control!

Can it be discussed: The fundamental factor in the treatment of drugs into the disease is to control the unique chemical and physical balance of the human body, in order to restore the body should have a stable state. However, because the structure or performance of chemical drugs is not well controlled, the harm is difficult to control. So how to control the chemical pharmacy, this article has a brief description.

The invention believes that how to scientifically control the safe and sequelae of food safety and the effective therapeutic function should be discussed in the following three aspects.

1. Ingestion of drugs into the human body must first have the function of normal excretion. This point must be given special attention. Human disease Because the treatment is often complicated, the drug is difficult to control the side effects, but as long as it can be excreted normally, it can effectively control to avoid any side effects.

2. The main structure of chemical drugs should be based on stable non-lytic type to reduce other side effects.

3. The chemical drug branch structure can be introduced into special therapeutic balance components according to different causes to achieve therapeutic purposes. Since the main chain is harmless and easy to excrete, even if there is an unpredictable abnormality, side effects sequelae can be avoided or reduced.

Combined with the above three points of discussion, the conclusion is that the controllable drugs should be used immediately and try to avoid side effects.

Summary of the invention:

In view of the above technical problems in the prior art, the present invention provides a silicone-modified acrylic polyester potassium salt, a preparation method thereof, and a cancer prevention and cancer treatment use, the silicone-modified acrylic polyester potassium salt and The preparation method and the anti-cancer and cancer-treating use are to solve the technical problems of the side effects of the drugs or health care products for preventing and treating cancer in the prior art which have large side effects and are not effective.

The invention provides a silicone modified acrylic polyester potassium salt prepared from acrylic acid or its esters, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water. The mass ratio of its ester, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water is 15.0 to 20.0: 0.7 to 2.0: 0.3 to 1.0: 6.0 to 10.0: 8.0 to 15.0: 52.0 to 70.0.

The invention also provides a preparation method of the above-mentioned silicone modified acrylic polyester potassium salt,

Including the following steps:

1) weighing acrylic acid or its esters, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water according to the mass percentage;

2) First add deionized water and isopropyl alcohol to a reactor for heating, preheat to 65-75 ° C, add 5 ~ 15% K ₂ S ₂ O ₈ , then heat to 78 ~ 85 ° C, start adding acrylic acid Or its esters, propylene silicone and 70-80% K ₂ S ₂ O ₈ , lasting 1 to 2 hours, adding the remaining K ₂ S ₂ O ₈ after the dropwise addition reaction, and keeping the temperature 1 to 2 at 85-90 ° C Hours, then cool to 65 ~ 75 ° C, add KOH to adjust the pH value of 7.0 ~ 8.0, then open at 65 ~ 75 ° C for 1 to 2 hours, then continue to cool to 30 ~ 50 ° C, filtered to obtain silicone modified Acrylic polyester potassium salt (referred to as silicon propane salt).

The present invention also provides the use of the above-mentioned silicone-modified acrylic polyester potassium salt in the preparation of a medicament or a health care product for treating or preventing cancer.

The present invention also provides the use of the above-mentioned silicone-modified acrylic polyester potassium salt as a food additive.

The invention also provides a medicine or a health care product, which is composed of the above-mentioned silicone-modified acrylic polyester potassium salt, isopropyl alcohol and deionized water, wherein the silicone-modified acrylic polyester potassium salt silicon propane salt Percentage of mass It is 5.0%, the isopropanol is 1.0 to 2.0%, and the deionized water is 93.0 to 94.0%.

The invention also provides a medicine or a health care product, which is composed of the above-mentioned silicone-modified acrylic polyester potassium salt and deionized water, wherein the mass percentage of the silicone-modified acrylic polyester potassium salt silicon propane salt At 5.0%, the deionized water was 95.0%.

Human innovative drugs must be combined with comprehensive chemistry to explore the chemical causes of the disease, and thus the targeted pharmaceuticals can be controlled, and reduce or even eliminate any side effects.

The prevention and treatment principle of the present invention is:

1. Main structure: Polypropylene chain, stable performance, difficult to crack and change, it is harmless, and its soft and hard properties, adhesion smoothness and other functions can be adjusted through different components. It is not easy to crack and absorb in the human body, but it can absorb a variety of organic wastes due to organic compounds and long-chain factors - such as in vivo food, benzene, organic carbon and other waste gas, waste residue, the main function is physical absorption cooperation. Excretion efficiency of wastes with inorganic wastes;

2, ~COOK, potassium acrylate chain, stable performance is not easy to crack, easy to excrete into the human body, with sterilization and drug absorption and adsorption of a variety of chemical group waste, the main effect is caused by the effect of van der Waals, conventional human salt can be effective Detoxification sterilization and blood circulation, but because it can be lysed into the body, once it exceeds the chemical and physical balance, the side effect is caused by the loss of control. However, this structure will not be absorbed by the human body, so there is no side effect, and it also has the function of promoting blood circulation. The potassium acrylate salt is set by a specific acid value to determine the degree of hydrolysis and the effective rate of excretion. The structure is a negative monovalent salt and meets hygienic requirements. Moreover, it also has the function of sterilizing and absorbing waste absorption;

3, X: active silicone - Si (OH) ₃ , Si (OCH ₃ ) ₃ , the efficacy of this product. Active silicone branch, active silicone can directly react with free metal ions, can also adsorb reactive oxide metal, and can displace the reaction to adsorb gastric acid metal salts, which is the unique physical and chemical effect of its active silicone.

Active silicone binding salt:

First, the same as lead:

Second, the same as arsenic:

Third, with the combination of gastric acid and chemical replacement:

(It has the same reaction effect as the gastric acid As salt, Cd salt, Cr salt, etc.)

Therefore, it can be determined that the branch component can avoid the control of gastric acid heavy metal salt forming gene, and can also adsorb or replace gastric acid heavy metal salt excretion, which is the scientific controllable reason for the anti-cancer and cancer treatment of the present invention. It is now known that active silicones are essential materials for human body (mostly from wheat bean food), which can effectively control minerals. The effective function of ingesting minerals is to control the overall balance of water, electricity and gas.

4. By-products that can be produced by the synthesis of silicon-propane salt:

a, double-stranded unreacted monomer: a small amount, due to the opening of the vapor evaporation, eliminating side effects;

b, potassium hydroxide KOH: trace, pH of 7.0 ~ 7.5, no side effects;

c, K ₂ SO ₈ : The salt is caused by the cleavage of a trace amount of K ₂ S ₂ O ₈ , the human body can be eaten with a salt medicine (a laxative), and there is no side effect.

5, the comprehensive structure is clear: FT-2016 is playing a clear role, no side effects.

The technical progress of the present invention is remarkable compared to the prior art. It has become increasingly clear that heavy metals are extremely harmful to humans! The main reason is that the formation of gastric acid heavy metal salts in the stomach has led to the current multi-gene gene for human cancer. Faced with the current reality, how to control the dangers of heavy metals should be a clear direction for human drug control. The silicone-modified acrylic polyester potassium salt of the present invention can control heavy metal toxicity, thereby rapidly preventing cancer and having a health care function.

detailed description:

Example 1

FT-2016: an active silicone modified acrylic polyester potassium salt (referred to as silicon propane salt), from acrylic acid or its esters, propylene silicone, potassium persulfate (reagent, pharmaceutical grade), isopropanol (reagent, Prepared by drug grade), potassium hydroxide (reagent, drug grade) and deionized water. The mass ratio of the acrylic acid or its ester, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water is 15.0 to 20.0: 0.7 to 2.0: 0.3 to 1.0: 6.0 to 10.0: 8.0. 15.0: 52.0 to 70.0.

Synthesis method: first add deionized water and isopropanol to a reactor for heating, preheat to 65-75 ° C, add 5 ~ 15% K ₂ S ₂ O ₈ , then heat to 78 ~ 85 ° C, start adding acrylic acid Or its esters, propylene silicone and 70-80% K ₂ S ₂ O ₈ , lasting 1 to 2 hours, adding the remaining K ₂ S ₂ O ₈ after the dropwise addition reaction, and keeping the temperature 1 to 2 at 85-90 ° C After an hour, then cool to 65-75 ° C, add KOH to adjust the pH value of 7.0-8.0, then open at 65-75 ° C for 1 to 2 hours, then continue to cool to 30 ~ 50 ° C, and filter to obtain FT-2016.

Example 2

FT-2016A: FT-2016, isopropanol and deionized water were weighed by mass percentage, and the mass percentage was: silicon propyl salt 5.0%, isopropyl alcohol 1.0-2.0%, deionized water 93.0-94.0%. First, add FT-2016 to a reaction vessel, add isopropanol, raise the temperature to 35-45 ° C, add deionized water, stir for 30-60 min, and cool and filter.

Example 3

FT-2016B: Weigh FT-2016 and deionized water by mass percentage, the mass percentage is: silicon propyl salt 5.0%, deionized water 95.0%. Firstly, FT-2016 is baked in a heater at 85-90 ° C for 1 to 2 hours to form a powdery silicon propane salt, which is obtained by adding deionized water.

Example 4 trial efficacy

FT-2016 (FT-2016A, FT-2016B) has been used in many places (Shanghai, Guangdong, Hong Kong, Taiwan, Japan, etc.) for nearly half a year. (drink 5ml / 3 ~ 7 days)

1, the stomach has a heterosexual disease: rapid excretion of dark black stool (multi-metal), the gram is a sense of overall comfort, more and more healthy, significantly treatment and preventive effects;

2, persistent constipation (youth, the elderly): quickly return to normal (this effect is very serious: overcome the cause of prevention of multiple diseases especially for young people);

3, Parkinson's disease (elderly): restore dietary excretion, sleep ventilation, sacral bones and other conditions;

5, tube cerebral infarction: rapid recovery of sleep, excretion, ventilation, activities and other effects, a little longer (January to February) that is to lose weight, reduce high blood pressure, high fat and other original symptoms;

6, other types of patients and routine health care providers: all quickly reach the effects of food, relaxation, vitality, sleep and other human body.

The above-mentioned trial users have been playing a clear role to date without side effects, and it can be seen that the present invention predicts the theory and effect.

Claims

A silicone-modified acrylic polyester potassium salt characterized by being prepared from acrylic acid or its esters, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water, said acrylic acid The mass ratio of its ester, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water is 15.0 to 20.0: 0.7 to 2.0: 0.3 to 1.0: 6.0 to 10.0: 8.0 to 15.0: 52.0 to 70.0.
The method for preparing a silicone-modified acrylic polyester potassium salt according to claim 1, comprising the steps of:

1) weighing acrylic acid or its esters, propylene silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water according to the mass percentage;

2) First add deionized water and isopropyl alcohol to a reactor for heating, preheat to 65-75 ° C, add 5 ~ 15% K 2 S 2 O 8 , then heat to 78 ~ 85 ° C, start adding acrylic acid Or its esters, propylene silicone and 70-80% K 2 S 2 O 8 , lasting 1 to 2 hours, adding the remaining K 2 S 2 O 8 after the dropwise addition reaction, and keeping the temperature 1 to 2 at 85-90 ° C Hours, then cool to 65 ~ 75 ° C, add KOH to adjust the pH value of 7.0 ~ 8.0, then open at 65 ~ 75 ° C for 1 to 2 hours, then continue to cool to 30 ~ 50 ° C, filtered to obtain silicone modified Acrylic polyester potassium salt.
The use of a silicone-modified acrylic polyester potassium salt according to claim 1 for the preparation of a medicament or a health care product for treating or preventing cancer.
Use of a silicone-modified acrylic polyester potassium salt as claimed in claim 1 as a food additive.
A pharmaceutical or health care product comprising: the silicone-modified acrylic polyester potassium salt according to claim 1, isopropanol and deionized water, wherein the silicone-modified acrylic polyester potassium salt The mass percentage of the silicon propane salt is 5.0%, the isopropanol is 1.0 to 2.0%, and the deionized water is 93.0 to 94.0%.
A pharmaceutical or health care product comprising: the silicone-modified acrylic polyester potassium salt according to claim 1 and deionized water, wherein the silicone-modified acrylic polyester potassium salt silicon propane salt The mass percentage was 5.0% and the deionized water was 95.0%.