CN105837734A - Organosilicone modified acrylic polyester potash, preparation method and application to cancer prevention and treatment - Google Patents
Organosilicone modified acrylic polyester potash, preparation method and application to cancer prevention and treatment Download PDFInfo
- Publication number
- CN105837734A CN105837734A CN201610301731.9A CN201610301731A CN105837734A CN 105837734 A CN105837734 A CN 105837734A CN 201610301731 A CN201610301731 A CN 201610301731A CN 105837734 A CN105837734 A CN 105837734A
- Authority
- CN
- China
- Prior art keywords
- organosilicon
- modified acrylic
- salt
- potassium
- deionized water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 title claims abstract description 42
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229920000728 polyester Polymers 0.000 title claims abstract description 30
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 19
- 201000011510 cancer Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000011282 treatment Methods 0.000 title claims description 4
- 229940072033 potash Drugs 0.000 title abstract 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 title abstract 6
- 235000015320 potassium carbonate Nutrition 0.000 title abstract 6
- 230000002265 prevention Effects 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000008367 deionised water Substances 0.000 claims abstract description 23
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 22
- 230000036541 health Effects 0.000 claims abstract description 13
- 150000002148 esters Chemical class 0.000 claims abstract description 12
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims description 42
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 12
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 11
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 5
- 235000019394 potassium persulphate Nutrition 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- KMNWCNNLFBCDJR-UHFFFAOYSA-N [Si].[K] Chemical compound [Si].[K] KMNWCNNLFBCDJR-UHFFFAOYSA-N 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- 229910001385 heavy metal Inorganic materials 0.000 abstract description 11
- 231100000614 poison Toxicity 0.000 abstract description 3
- 239000002574 poison Substances 0.000 abstract description 2
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 41
- 239000000126 substance Substances 0.000 description 21
- 108090000623 proteins and genes Proteins 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 210000004211 gastric acid Anatomy 0.000 description 13
- 201000010099 disease Diseases 0.000 description 10
- 229910001868 water Inorganic materials 0.000 description 8
- 238000005336 cracking Methods 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 7
- 229910052710 silicon Inorganic materials 0.000 description 7
- 239000010703 silicon Substances 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 230000029142 excretion Effects 0.000 description 6
- 231100000957 no side effect Toxicity 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000002699 waste material Substances 0.000 description 6
- 229910002567 K2S2O8 Inorganic materials 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- -1 electricity Substances 0.000 description 5
- 230000005611 electricity Effects 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 206010017758 gastric cancer Diseases 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 210000000476 body water Anatomy 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000004223 radioprotective effect Effects 0.000 description 3
- 201000011549 stomach cancer Diseases 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000599 controlled substance Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- YADSGOSSYOOKMP-UHFFFAOYSA-N lead dioxide Inorganic materials O=[Pb]=O YADSGOSSYOOKMP-UHFFFAOYSA-N 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 239000002912 waste gas Substances 0.000 description 2
- VAPQAGMSICPBKJ-UHFFFAOYSA-N 2-nitroacridine Chemical class C1=CC=CC2=CC3=CC([N+](=O)[O-])=CC=C3N=C21 VAPQAGMSICPBKJ-UHFFFAOYSA-N 0.000 description 1
- 108091005508 Acid proteases Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 150000005693 branched-chain amino acids Chemical class 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000013015 e-cracking Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000005658 nuclear physics Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- ZUBIJGNKOJGGCI-UHFFFAOYSA-M potassium;prop-2-enoate Chemical group [K+].[O-]C(=O)C=C ZUBIJGNKOJGGCI-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/04—Acids; Metal salts or ammonium salts thereof
- C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides organosilicone modified acrylic polyester potash. The organosilicone modified acrylic polyester potash is prepared from acrylic or esters thereof, acrylic silicone, potassium persulfate, isopropanol, potassium hydroxide and deionized water according to the mass ratio of (15.0-20.0): (0.7-2.0): (0.3-1.0): (6.0-10.0): (8.0-15.0): (52.0-70.0). The invention further provides a preparation method of the organosilicone modified acrylic polyester potash. The invention further provides application of the organosilicone modified acrylic polyester potash to preparation medicine or healthcare products for treating or preventing cancer. The organosilicone modified acrylic polyester potash can control heavy metal poison so that cancer can be prevented and treated rapidly, and a health care function is achieved.
Description
Technical field
The invention belongs to biomedicine field, relate to a kind of health product, specifically a kind of organosilicon-modified acrylic
Polyester potassium salt and preparation method and cancer preventing and treating purposes.
Background technology:
(1), a kind of raw son (life base) of new base S
S is a kind of base flexibly.
S is formed by (especially H nucleon) accumulation in photon radiation atomic nucleus, it is provided that then energy for promoting disorder of internal organs proton promotes
Returning decrement photon after atomic reaction the most again, therefore it is a kind of life type base given birth to and can take leave.
Photon the most easily enters H nucleon (H atom core one piece of electronics of only one layer electron cloud), therefore the most easily generates S in H atom core
Son.
Photon the most easily enters C, O, N nucleon (the most only two layers electron cloud of atomic nucleus, electronics is also few), so easily promoting core, also
S can be generated and promote core further.
It is as follows that human survival mainly affects atom:
Nature biotechnology originates from: pure H2O、CO2State, photon radiation H particle generates raw son → actuate H proton → actuate H electricity
Son → H2The micro-electric cracking → of O and CO2In conjunction with → form nature and come into being organic carbon hydrate → the most progressively generate plant → dynamic
Thing, the mankind.
Here it is nature biotechnology generates origin, light radioprotective is the primary physical chemistry source element of natural biology, and S is special
Base to be generated！
Human life's gene element: metabolism.In human body, Organic substance just loses raw son because lasting, and loses motility, empty
Between with type organic then because light core is rich in raw son, so human body to eat this allied substances the most replaceable, regulate and control motility.
Here it is the existence that C, H, O, N can be formed with chemical machine life entity will be, S is exactly life base among these
Son.Spy to illustrate: photon (quality is 0) itself not charged but can attached micro-electric charge, therefore photon enter atomic nucleus accumulation can
Form raw son to accumulate micro-electric charge and promote core effect to rise, but S what does the total come to that micro-energy need inquire into checking after the mankind.
(2), synthetic chemistry (a set of discussion life gene new theory)
This theory proposes the principles such as comprehensive organic chemistry, inorganic chemistry, biochemistry, nuclear physics chemistry, with final comprehensive
It is basic that basic base of life gene material molecule (atomic nucleus, proton, electronics, neutron, raw son, photon) can explore life gene
Ji Li, to reach the controlled the most fruit of science.
One, synthetic chemistry (human body generates gene and inquires into) Ji Li:
The sub-effect of light core effect → life → atom Edward effect → atom combination → organic chemical reactions → formation molecule
Gene.
Two, control health to manage: water, electricity, gas synthetic chemistry physical equilibrium.
Three, human medicine innovation direction: primarily have no side effect for base or reduce side effect, secondly harm is just improving for specific aim
Effect.
Four, heightened awareness at present because of day by a large amount of energy consumptions make cause environmental pollution serious harm, the mankind should strengthen unite
Unite day again by causing common attention to take precautions against by reinforcement is common also day.Really rescue the mankind: prevent front, cure the disease rear！
(3), the primary multiple gene gastric acid heavy metallic salt of the current cancer of the mankind
Stomach is digestion, and normal person must eat many animals and plants every day and prolong life, and human body is multiple in a large number for every day just
At miscellaneous chemical reaction head and maximum.So should be understood that its positive interaction is very big, often side effect is the most maximum.The current cancer of the mankind
Disease i.e. illustrates this reason so that gastric cancer rate is the highest.
Stomach is at acid number relatively big (PH ≈ 1～2) and oxygen-enriched state cracking food, its normal chemical cracking Main Ingredients and Appearance
Should be:
Aminoacid (mostly is α, β type), draws for human body Major Nutrient or excretion；
Organic acid, carbohydrate, salt, water, need to absorb or excretion for human body；
Carbon dioxide (O is combined with lytic activity carbon), toxin expelling effect, must let out.
After stomach dirty itself and digestion reaction, its primary chemical function thing is i.e. carboxyl (-COOH) undoubtedly, carboxyl easily with
Become salt after metal reaction, be specially described as follows:
1 and potassium, sodium form negative monovalent salt.Little, thin, alive, flexible to human body water, electricity, gas water conservancy diversion, easy Metabolism Excretion；
2 and calcium, ferrum form negative divalent salts, in, carefully, the most alive, provide appropriateness toughness for skeleton etc. and red blood be provided
Ball, again can metabolism, providence 10000 years arranges life；
3 and heavy metal form high negative valency salt (>=2), big, thick, solid, be difficult to Metabolism Excretion.Undeniable, needed by human is taken the photograph
Enter micro heavy with the device matter such as tough and tensile tooth, bone, muscle and other strong raw functions, but more it should be appreciated that heavy metallic salt curable is real
The highest, and also hide necessarily radiate can, so once its sequela of ultramicron must be great fatal.
Cancer is human body uncontrollable foreign body object protein.Generally believe that gastric cancer forming factors is mainly eaten organic at present
Amine, nitrite, aromatic compound, mycete etc. make cause.It is carcinogenic that such poisonous substance can make the cause dirty exception of stomach really, but from its chemistry angle
For degree, its reaction result not absolutely plays destruction, and can not with the side effect of gastric acid heavy metallic salt relatively.
Acid becomes salt chemistry direction result fixing clear with metal, and gastric acid becomes salt to be multi-ring racemosus salt and big nuclear energy with heavy metal
Salt, it can destroy rapidly gastric acid digestive function, and be difficult to metabolism, once ultramicron or time one grow disease because of, with much money
Belonging to pathogenic into stomach is certainly.Current human ecological environment is just because of the huge waste gas waste residue that also causes of the daily power consumption of the mankind, everyday
Number beyond count, disastrous effect maximum among these is i.e. to have every day immesurable heavy metal to spread ground, for animals and plants and water source
Absorb and finally enter human body in a large number.
It can be extrapolated that just impact of heavy metals (multi-ring racemosus salt and big nuclear energy salt) be cause Human Gastric carcinoma main because of
Element, and, the dirty foreign body object protein gene formed of stomach also can shift other internal organs cancers of human body and move change the most also
Such gene can be formed.Can draw a conclusion: heavy metal pollution is that the most or else the current mankind injure the factor of maximum
Control, with the passing of time must ruin the mankind！
Synthetic chemistry discussion is used to infer gastric acid heavy metallic salt genetic traits.
Control health to be managed and to be to ensure that human body water, electricity, gas synthetic chemistry physical equilibrium, then destroy this kind of balance
It is exactly to injure human body.The chemical substance that obviously as long as human body contact is the most active or the most inflexible, people will be caused in life.This is existing
The most repeatedly mankind's tragedy confirms.Cross reviver: bacterial infection, activity organic amine, cyanide salt etc., it can destroy rapidly reaction people
Body catalysis biological enzyme, causes body metabolism the most out of control so that getting killed；Cross the dead: be heavy metal activity thing, uncontrollable generation
Thank, the most also must get killed.
Gastric acid salt chemical constitution:
May infer that: what inflexible type was hurted sb.'s feelings most is i.e. Pb salt, As salt, chemical combination gene not only fixed pattern is the highest is difficult to generation for such
Thank and multi-ring racemosus is more likely formed unmanageable multiple badization reaction result.
Discuss and infer heavy metallic salt destruction gene and metastatic gene:
If 1 certain side chain is formed by combination and gastric acid protease～COO chain, then its result is equal to antibacterial
Property destroy, and be difficult to transfer, gastric cancer can be formed quickly；
2, such side chain is many based on aminoacid, can stagnant gastric or transfer absorbed, be transferred to intestinal, liver, gallbladder, kidney are i.e. formed
Destroy gene at this, roll up cancer；
3, the flowing activity that branched-chain amino acid molecular weight is little is high, easily proceeds to blood vessels and pulmonary, forms cancer at this；
4, such amino acid salts can be clearly organic amine salt the most, therefore once enter blood vessels and can increase a few class leukocyte
And be difficult to displacement, form leukemia, here it is the event of the mankind's rapid enhancing rate of leukemia of nearly stage；
5, for structure, arsenic salt seems higher than lead salt damage degree, but actually this is not so, it is known that: human metabolism must
There is raw sub-release, promote core in conventionally photon is not easily accessible the heavy metal core of multilayer electronic cloud, but once accumulation rush core will
Form radioprotective.C, H, O Organic substance is easily inhaled raw son and is the most easily discharged raw son, internal vexed long-pending time length easy entrance lead core, is formed
Fatal radioprotective！
Current environment is heavy due to many lead contaminations day energy consumption day, therefore in the comprehensive judgement of Chemical Physics: lead is to endanger people at present
The primary dirt that class is healthy.The mankind must control especially.
Summary theoretical invention is discussed: medicine is the necessary of human survival, and current society is rapid due to progress,
Create many edible-type medicines in the world, make many contributions for curing the sickness to save the patient, undeniable；But numerous medicines are eaten the mankind
The hazardness side effect caused after with the most day by day increases, it should be noted that control！
Could discuss: medicine is eaten its basic factor of curing the disease and controlled the Chemical Physics balance that human body is peculiar exactly, to recover
Human body is former should steady statue.But often due to its structure of chemicals or performance are not deeply conscious of controlled, then its hazardness is the most just
It is difficult to controlled.So how controllability carries out chemical pharmacy, has sketched.
It is considered herein that how the few sequela of science controlled medicine edible safety and actual effect disease cure function should be in following three
Aspect is discussed.
1, eating medicine entrance needed by human and first possess the function of normal excretion, this point must be paid attention to especially.People
The body cause of disease often complex, medicine is to side effect difficulty control, but as long as energy normal excretion, it is possible to effectively control to avoid it any
Side effect.
2, chemicals agent structure should avoid other side effect based on the non-cracking type of stability to reduce.
3, chemicals branched structure can introduce special type treatment equilibrium composition according to different pathogeny, to reach purpose of curing the disease.
The most easily drain owing to main chain is harmless, even if so having and not surveying exception, it is possible to avoid or reduce side effect sequela.
Discuss it is concluded that controlled drug should i.e. have just pays with avoiding side effect the most as far as possible in conjunction with above-mentioned 3.
Summary of the invention:
For above-mentioned technical problem of the prior art, the invention provides a kind of organosilicon-modified acrylic polyester potassium salt
And preparation method and cancer preventing and treating purposes, described this organosilicon-modified acrylic polyester potassium salt and preparation method and anti-cancer are controlled
The side effect that cancer purposes to solve the medicine of anti-curing cancers of the prior art or health product is big, and the technology of poor effect is asked
Topic.
The invention provides a kind of organosilicon-modified acrylic polyester potassium salt, by acrylic acid or its esters, propylene organosilicon,
Potassium peroxydisulfate, isopropanol, potassium hydroxide and deionized water are prepared from, described acrylic acid or its esters, propylene organosilicon, mistake
The mass ratio of potassium sulfate, isopropanol, potassium hydroxide and deionized water be 15.0～20.0:0.7～2.0:0.3～1.0:6.0～
10.0:8.0～15.0:52.0～70.0.
Present invention also offers the preparation method of above-mentioned a kind of organosilicon-modified acrylic polyester potassium salt,
Comprise the steps:
1) acrylic acid or its esters, propylene organosilicon, potassium peroxydisulfate, isopropanol, hydroxide are weighed according to mass percent
Potassium and deionized water；
2) first deionized water and isopropanol are added a reactor heating, is preheated to 65～75 DEG C, adds 5～15%
K2S2O8, it is again heated to 78～85 DEG C, starts to drip acrylic acid or its esters, propylene organosilicon and 70～the K of 80%2S2O8, go through
Time 1～2 hour, dropwise reaction terminate add residue K2S2O8, 85～90 DEG C be incubated 1～2 hour, be subsequently cooled to 65～
75 DEG C, add KOH and regulate pH value 7.0～8.0, then wave gas 1～2 hours in 65～75 DEG C of open natures, be further continued for being cooled to
30～50 DEG C, filter and i.e. obtain organosilicon-modified acrylic polyester potassium salt (being called for short silicon the third salt).
Present invention also offers above-mentioned organosilicon-modified acrylic polyester potassium salt in preparation treatment or prophylaxis of cancer
Application in medicine or health product.
Present invention also offers above-mentioned organosilicon-modified acrylic polyester potassium salt as the application in food additive.
Present invention also offers a kind of medicine or health product, by above-mentioned organosilicon-modified acrylic polyester potassium salt, different
Propanol and deionized water composition, wherein, the mass percent of described organosilicon-modified acrylic polyester potassium salt silicon the third salt is
5.0%, described isopropanol 1.0～2.0%, described deionized water 93.0～94.0%.
Present invention also offers a kind of medicine or health product, by above-mentioned organosilicon-modified acrylic polyester potassium salt with go
Ionized water forms, and wherein, the mass percent of described organosilicon-modified acrylic polyester potassium salt silicon the third salt is 5.0%, described
Deionized water 95.0%.
Mankind's original new drug must be visited in conjunction with synthetic chemistry and grind disease chemistry cause, and the pharmacy of being thus directed towards property is controlled, and
Reduce and even stop its any side effect.
The principle of preventing and treating of the present invention is:
1, agent structure: polypropylene chains, stable performance is difficult to crack mutation, its non-hazardous, can pass through different components
Regulate its soft or hard, adhere to the functions such as flatness.I.e. enter human body be difficult to cracking absorb, but itself because of have organic compound and
Long-chain factor can adsorb waste gas, the waste residues such as the most internal food of multiple debirs, the benzene of medicine cracking, organic carbon, main
Effect is physics adhesive effect and inorganic matter waste residue waste discharge effect；
2～COOK, acrylic acid potassium salt side chain, stable performance is difficult to cracking, enters human body and easily drain, and has sterilization and takes drugs
And adsorb multiple chemical group waste discharge effect, main effect is caused by Van der Waals effect, and Regular Human's Sal can be effective
Toxin expelling sterilizes and invigorates blood circulation guide functions, but draws therefore once release souls from purgatory can cause that Chemical Physics balance is out of control to be led because its cleavable enters body
Cause side effect, but this structure will not be adsorbed for human body, therefore have no side effect, and also there is lively atmosphere diversion function of invigorating blood circulation；Potassium acrylate
Salt, is set by specific acid number, and to determine degree of hydrolysis and effectively to drain fast slowness, this structure is negative monovalent salt, reaches health and wants
Ask.And, also there is sterilization drug abuse and absorb waste discharge function；
3, X: active organosilicon Si (OH)3、Si(OCH3)3, this product drug effect is originally.Active organosilicon side chain, activity is organic
Silicon can be with direct reaction free metal ion, it is also possible to adsorption reaction metal oxide, it is possible to displacement reaction absorption gastric acid
Metalloid salt, is the peculiar physical chemistry effect of its active organosilicon.
Active organosilicon combines salt:
One, close with leaded:
～Si (OH)3+PbO2→～Si (OH)3·PbO2
Two, with arsenic chemical combination:
～Si (OH)3+HAsO2→～Si (OH3)·HAsO2
Three, with gastric acid salt binding and chemical replacement:
(becoming above-mentioned generic reaction effect with gastric acid class As salt, Cd salt, Cr salt etc.)
Therefore can determine that this side chain component can be avoided controlling gastric acid heavy metallic salt and form gene, can adsorb or replace again
Gastric acid heavy metallic salt is drained, here it is the controlled place to be managed of the science of cancer preventing and treating of the present invention.The mankind have known active organosilicon
Being needed by human existence material (mostly deriving from wheat bean food), it can effectively control mineral substance.And eat having of mineral substance
Effect function, is i.e. to control the aggregate balancings such as human body water, electricity, gas.
4, the by-product that silicon the third salt building-up process can produce:
A, double-strand unreacted monomer: trace, wave gas evaporation because opening, reject side effect；
B, potassium hydroxide KOH: trace, pH, in 7.0～7.5, has no side effect；
c、K2SO8: trace K2S2O8Cracking is caused is originally salt, and human body edible salts medicine (laxative) etc. also has no side effect.
5, compages are clear and definite: FT-2016 positive interaction is clear and definite, and base has no side effect.
The present invention compares with prior art, and its technological progress is significant.Known: heavy metal is to the mankind
Very harmful！Its main base reason i.e. forms gastric acid heavy metallic salt in gastric and makes the cause primary multiple gene of current human cancer.Faced by
How current reality, control Heavy Metal Pollution, should be the mankind and creates the specific direction that medicine controls.The present invention's is organic-silicon-modified
Acrylic polyester potassium salt can control heavy metal poison, thus can rapid anti-curing cancers, and there is the effect of health care.
Detailed description of the invention:
Embodiment 1
FT-2016: a kind of active organosilicon modified propylene acid polyester potassium salt (is called for short silicon the third salt), by acrylic acid or its ester
Class, propylene organosilicon, potassium peroxydisulfate (reagent, medicine level), isopropanol (reagent, medicine level), potassium hydroxide (reagent, medicine level) and go from
Sub-water is prepared from.Described acrylic acid or its esters, propylene organosilicon, potassium peroxydisulfate, isopropanol, potassium hydroxide, deionization
The mass ratio of water is 15.0～20.0:0.7～2.0:0.3～1.0:6.0～10.0:8.0～15.0:52.0～70.0.
Synthetic method: first deionized water and isopropanol are added a reactor heating, is preheated to 65～75 DEG C, adds 5
～15%K2S2O8, it is again heated to 78～85 DEG C, starts to drip acrylic acid or its esters, propylene organosilicon and 70～80%
K2S2O8, lasting 1～2 hour, dropwise reaction terminates to add the K of residue2S2O8, it is incubated 1～2 hour at 85～90 DEG C, the coldest
But to 65～75 DEG C, add KOH and regulate pH value 7.0～8.0, then wave gas 1～2 hours in 65～75 DEG C of open natures, followed by
Continue and be cooled to 30～50 DEG C, filter and i.e. obtain FT-2016.
Embodiment 2
FT-2016A: weigh FT-2016, isopropanol and deionized water by mass percentage, mass percent is: silicon the third salt
5.0%, isopropanol 1.0～2.0%, deionized water 93.0～94.0%.In a reaction vessel, first add FT-2016, then
Add isopropanol, be warming up to 35～45 DEG C, add deionized water, stir 30～60min, cold filtration and get final product.
Embodiment 3
FT-2016B: weigh FT-2016 and deionized water by mass percentage, mass percent is: silicon the third salt 5.0%,
Deionized water 95.0%.In FT-2016 first combines in a heater, 85～90 DEG C of bakings form powdery silicon the third salt in 1～2 hour,
Take converts and deionized water and get final product.
Embodiment 4 tries out effect
How FT-2016 (FT-2016A, FT-2016B) lasts (Shanghai, Guangdong, Hong Kong, Taiwan, Japan in of nearly half a year
Deng) many people trial effect.(once drink 5ml/3～7 days)
1, stomach has different disease person: excrete rapidly atrous stool (multi-metal class), and i.e. sense of setting a date is overall happy, with the passing of time gets over
Come the most healthy, significantly treat and prevent effect；
2, lasting constipation person (young, old man): recovering rapidly normally, (this effect is the heaviest: overcome the many diseases of causal prophylaxis special
For adolescence)；
3, Parkinson's disease person (old man): recover the shapes such as diet is drained, sleep is ventilated, tibia is happy；
5, pipe cerebral infarction disease person: effects such as recovering rapidly to sleep, drain, ventilate, be movable, slightly for a long time (1～February) i.e. lose weight, drop
Low hypertension, original symptom such as higher fatty acid；
6, other multiclass disease person and routine healthcare person: reach the most rapidly the happy effects of human body such as food is let out, lively atmosphere, dormancy are dynamic.
The clear and definite base of above-mentioned trier positive interaction so far has no side effect, it is seen that card present invention contemplates that theory and effect.
Claims (6)
1. an organosilicon-modified acrylic polyester potassium salt, it is characterised in that: by acrylic acid or its esters, propylene organosilicon, mistake
Potassium sulfate, isopropanol, potassium hydroxide and deionized water are prepared from, described acrylic acid or its esters, propylene organosilicon, over cure
Acid potassium, isopropanol, the mass ratio of potassium hydroxide and deionized water be 15.0～20.0:0.7～2.0:0.3～1.0:6.0～
10.0:8.0～15.0:52.0～70.0.
2. the preparation method of a kind of organosilicon-modified acrylic polyester potassium salt described in claim 1, it is characterised in that include as
Lower step:
1) according to mass percent weigh acrylic acid or its esters, propylene organosilicon, potassium peroxydisulfate, isopropanol, potassium hydroxide and
Deionized water；
2) first deionized water and isopropanol are added a reactor heating, is preheated to 65～75 DEG C, adds 5～the K of 15%2S2O8,
It is again heated to 78～85 DEG C, starts to drip acrylic acid or its esters, propylene organosilicon and 70～the K of 80%2S2O8, last 1～2
Hour, dropwise reaction terminates to add the K of residue2S2O8, it is incubated 1～2 hour at 85～90 DEG C, is subsequently cooled to 65～75 DEG C, adds
Enter KOH and regulate pH value 7.0～8.0, then wave gas 1～2 hours in 65～75 DEG C of open natures, be further continued for being cooled to 30～50
DEG C, filter and i.e. obtain organosilicon-modified acrylic polyester potassium salt.
3. a kind of organosilicon-modified acrylic polyester potassium salt described in claim 1 is at preparation treatment or the medicine of prophylaxis of cancer
Or the application in health product.
4. a kind of organosilicon-modified acrylic polyester potassium salt described in claim 1 is as the application in food additive.
5. a medicine or health product, it is characterised in that: by the organosilicon-modified acrylic polyester potassium described in claim 1
Salt, isopropanol and deionized water composition, wherein, the mass percent of described organosilicon-modified acrylic polyester potassium salt silicon the third salt
It is 5.0%, described isopropanol 1.0～2.0%, described deionized water 93.0～94.0%.
6. a medicine or health product, it is characterised in that: by the organosilicon-modified acrylic polyester potassium salt described in claim 1
Forming with deionized water, wherein, the mass percent of described organosilicon-modified acrylic polyester potassium salt silicon the third salt is 5.0%,
Described deionized water 95.0%.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610301731.9A CN105837734A (en) | 2016-05-09 | 2016-05-09 | Organosilicone modified acrylic polyester potash, preparation method and application to cancer prevention and treatment |
| PCT/CN2016/087162 WO2017193458A1 (en) | 2016-05-09 | 2016-06-24 | Organosilicone modified acrylic polyester potassium salt and preparation method and use in prevention and treatment of cancer |
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| CN201610301731.9A CN105837734A (en) | 2016-05-09 | 2016-05-09 | Organosilicone modified acrylic polyester potash, preparation method and application to cancer prevention and treatment |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1795001A (en) * | 2003-05-22 | 2006-06-28 | 沃尔夫·鲍尔 | Medicament for internal application, in particular against cancerous diseases |
| CN102977253A (en) * | 2012-11-06 | 2013-03-20 | 中科院广州化学有限公司 | Silicone modified acrylate hybrid emulsion and preparation method and application thereof |
| CN104115924A (en) * | 2014-07-21 | 2014-10-29 | 上海惠昌化工厂 | Fruit wax for maintaining freshness of fruits and preparation method of fruit wax |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6358557B1 (en) * | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
| CN1204192C (en) * | 2002-12-19 | 2005-06-01 | 杨慕杰 | Organic sillicon modified acrylic ester/inorganic nano composite emulsion and its preparation |
| CN100554299C (en) * | 2007-04-27 | 2009-10-28 | 兰州交通大学 | Compounded latex of silicone resin and acrylic polymer and preparation method thereof |
| CN100567347C (en) * | 2007-06-22 | 2009-12-09 | 中国科学院广州化学研究所 | A kind of siloxanes reunion acryhic material and synthetic technology thereof of containing |
| CN102643385B (en) * | 2012-05-10 | 2014-05-21 | 西北师范大学 | Organic silicon-acrylic ester copolymer emulsion and preparation and application thereof |
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2016
- 2016-05-09 CN CN201610301731.9A patent/CN105837734A/en active Pending
- 2016-06-24 WO PCT/CN2016/087162 patent/WO2017193458A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1795001A (en) * | 2003-05-22 | 2006-06-28 | 沃尔夫·鲍尔 | Medicament for internal application, in particular against cancerous diseases |
| CN102977253A (en) * | 2012-11-06 | 2013-03-20 | 中科院广州化学有限公司 | Silicone modified acrylate hybrid emulsion and preparation method and application thereof |
| CN104115924A (en) * | 2014-07-21 | 2014-10-29 | 上海惠昌化工厂 | Fruit wax for maintaining freshness of fruits and preparation method of fruit wax |
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Application publication date: 20160810 |