WO2017182887A2 - Injection device - Google Patents

Abstract

An injection device 1 for injecting contents into a subject by means of a syringe, which is provided with a plunger, a barrel into which the plunger is inserted, and a needle comprising a needle hub that connects to the barrel and a shaft that is inserted into a subject, is provided with: a contact head 10 that can make contact with the subject, and has an opening formed therein through which the needle passes; a movable holder 30 that holds the barrel and the needle; a support mechanism 20 that is fixed to the contact head; and a content injection control mechanism 50 that pushes the plunger inside the barrel. The barrel and the needle are made to move with respect to the contact head as a result of the movable holder moving along the support mechanism. The syringe can be attached to and detached from the injection device.

Description

Injection device

The present invention relates to an injection device, and more specifically to a device suitable for injecting, supplying, or administering various substances including cells into a tissue.

In cell therapy or the like, it may be desirable to inject a predetermined substance such as a cell into a treatment site in the skin precisely and in a desired amount at a predetermined depth.

Furthermore, when a small amount of a substance such as a cell is injected into a single layer or a single region, a predetermined amount may be divided into multiple times and distributed in a plurality of different directions. Necessary.

In addition, when the predetermined amount of content is divided into a plurality of times and injected in a distributed manner from a plurality of different directions, it is desirable that the influence on the subject is equally divided. It may be desired to be injected at the same predetermined rate each time.

In order to solve such a problem, an injection needle housing for fixing the injection needle is provided in the injection device, the injection needle is fixed inside, and the syringe barrel is detachably attached to the fixed injection needle. Patent Document 1 is proposed. In this injection apparatus, an injection operation is performed at a predetermined speed by an internal drive system and a retraction system.

JP-T-2015-505487

However, in the technique of Patent Document 1, since the injection needle is fixed inside, when injection is performed on a plurality of patients or subjects using this device, infection such as infectious diseases, infectious diseases, and the injection needle Since the risk of puncture pain due to wear or the like is high, it is necessary to make the injection device itself disposable.

Furthermore, in the structure in which the target injection device and the injection needle for the syringe are integrated without being attached or detached, the device may be handled as a more advanced medical device, and the notification and conveyance of the device become strict. There was a fear.

In addition, when a substance having a gel-like structure with high viscosity is used as a content to be injected by injection, a high pressure is applied during use, and the syringe barrel may come off with respect to the fixed injection needle.

Therefore, in view of the above circumstances, the present invention aims to provide an injection device that prevents the injection needle from falling off from the syringe barrel during use and can be attached to and detached from the syringe.

According to one aspect of the present invention, there is provided a syringe including a pusher, a syringe barrel into which the pusher is inserted, and a needle base connected to the syringe barrel and a needle tube punctured into a subject. An injection device for injecting contents into the subject is capable of contacting the subject and has a contact head formed with an opening through which the needle tube passes; a movable holding the syringe barrel and the injection needle A holder; a support mechanism fixed to the abutment head; and a content injection control mechanism for pushing the pusher into the syringe barrel, and the movable holder moves along the support mechanism. Thus, the syringe barrel and the injection needle are moved relative to the contact head, and the syringe is detachable from the injection device.

According to one aspect of the present invention, the injection device can prevent the syringe needle from falling off from the syringe barrel and remove the syringe during use.

Explanatory drawing of the injection apparatus of 1st Embodiment of this invention. The block diagram of the syringe applied to the injection apparatus of this invention. Explanatory drawing of the movable holder in the injection device of FIG. Explanatory drawing of the movable holder and support mechanism in the injection device of FIG. Explanatory drawing of the moving mechanism and rod-shaped member in the lower surface of the movable holder shown in FIG. Explanatory drawing of the ratchet mechanism in the press part in the injection device of FIG. Explanatory drawing of the contact head in the injection apparatus of FIG. Operation | movement explanatory drawing of the injection apparatus which concerns on 1st Embodiment of this invention. Explanatory drawing of the injection operation | movement flow which concerns on 1st Embodiment. The injection apparatus of 2nd Embodiment of this invention. FIG. 11 is an enlarged view of a needle extraction control mechanism of the injection device of FIG. 10. FIG. 11 is a perspective view of the injection device of FIG. 10. Operation | movement explanatory drawing of the injection apparatus which concerns on 1st Embodiment of this invention. Explanatory drawing of the injection operation | movement flow which concerns on 2nd Embodiment. Explanatory drawing in the case of marking a subject using a template for injection. Explanatory drawing of the attachment procedure of a syringe. The figure which made the injection apparatus contact | abut to the injection device with which the injection device was mounted | worn, and a test object.

FIG. 1 is an explanatory diagram of the injection device according to the first embodiment of the present application. (A) is a sketch and (b) is a side view.

[Overall description]
The injection device 1 is an injection device to which a syringe that injects a content containing a substance such as a cell suspension into a subject (human, animal, individual organ, skin, etc.) is attached. The injection device 1 functions as an injection syringe holder (injector holder) for injecting an appropriate amount of contents into a subject using a syringe.

The injection device includes a contact head 10, a support mechanism 20, a movable holder 30, and a content injection control mechanism 50.

The contact head 10 can contact the subject and has an opening. The contact head 10 is located at the tip of the injection device 1. When a later-described needle tube 83 performs a puncture operation / needle extraction operation on a subject, the tube passes through the opening 11 (see FIG. 4B).

The support mechanism 20 is fixed to the contact head 10 at a predetermined angle. The injection angle with respect to the subject is set by the coupling angle between the support mechanism 20 and the contact head 10. The abutting head 10 and the support mechanism 20 may be integrally manufactured, or may be fixed separately by welding or the like after manufacturing.

The support mechanism 20 is a holder receiving part that defines the stop position of the movement of the movable holder 30 and receives the movable holder 30.

The movable holder 30 holds the syringe barrel 84 and the injection needle 81 (see FIG. 2A) and is movable along the support mechanism 20 with respect to the contact head 10. By moving the movable holder 30 relative to the contact head 10, the syringe cylinder 84 and the injection needle 81 held by the movable holder 30 are moved with respect to the subject in contact with the contact head 10. By this relative movement, the needle tube 83 of the syringe 80 moves relative to the subject in a forward direction that is a puncturing direction and a backward direction that is a direction in which the needle is removed.

The content injection control mechanism 50 pushes the pusher 88 into the syringe barrel 84. The content injection control mechanism includes a pressing portion 40, a guide rod 51, an interlocking rod 52, a connecting rod 53, and elastic members 54 and 55 (see FIG. 5).

Here, in the injection device 1 of the present invention, the syringe barrel and the injection needle are detachable as a syringe. FIG. 2 is an explanatory view of the syringe, wherein (a) shows the assembled syringe, and (b) shows an exploded view of the syringe.

As shown in FIG. 2, the syringe 80 includes an injection needle 81, an injection cylinder 84, and a pusher 88. A syringe cylinder (cylinder) 84 accommodates the contents, and a pusher 88 is inserted. Specifically, the syringe cylinder 84 includes an outer cylinder portion 85 that stores the contents, a flange 86 provided at the rear end of the outer cylinder portion 85, and a cylinder tip 87.

Here, it is preferable that a syringe having a volume of 1 mL is used in the injection device of the present invention. Such a 1 mL syringe allows for 10 100 μL injections and 6 166 μL injections. Syringes with 2, 5, or 10 mL can also be used. Depending on the specific mode of use of the injection device, the syringe may have a larger or smaller volume.

The injection needle 81 is connected to the syringe barrel 84. Specifically, the injection needle 81 includes a needle base 82 that is externally fitted to the tube tip 87 of the injection tube 84 and a needle tube 83 that is punctured into the subject. When setting the syringe 80, the tube tip 87 of the syringe tube 84 is inserted into the needle base 82 of the injection needle 81 and engaged. You may use the syringe which has a structure which locks so that the needle base 82 of the injection needle 81 and the cylinder tip 87 of the injection cylinder 84 may not remove easily.

Here, the diameter of the needle tube of the injection needle applied to the injection device of the present invention is preferably in the range of 18 to 34G, 20 to 30G. More preferably, it is 26G, 27G, or 30G.

The pusher 88 (plunger) is moved in the outer cylinder part 85 of the injection cylinder 84 by pressing the head (rear part) 88h, whereby the contents are released from the syringe. A gasket 89 which is a thin rubber packing (sealing element) for preventing liquid leakage and foreign matter mixing is bonded to the tip of the pusher 88.

Here, in the present invention, since the syringe cylinder 84 and the injection needle 81 as shown in FIG. 2A can be integrated and detached together, the contents contained in the syringe cylinder 84 are The injection device 1 can be reused without adhering to the inside or with as little adhesion as possible. Here, the injection tube 84 and the injection needle 81 need only be integrated by connection at least when being attached to and detached from the injection device 1 and mounted in the injection device 1. When outside, the syringe tube 84 and the injection needle 81 may be in separate states.

[Movable holder (syringe holder)]
FIG. 3 shows an enlarged cross-sectional view of the upper surface of the movable holder 30. (A) is a perspective view, (b) is a cross-sectional top view cut along AA ′ in (a).

The movable holder 30 is formed with a syringe holder made up of a front holder 310 and a rear holder 320, and two through holes (331, 332, see FIG. 5) through which the rod-shaped members 51, 52, 53 pass. The moving support part 330 is provided. In addition, coil springs 54 and 55 which are first elastic members are provided inside the movement support portion 330.

The upper part 310 and 320 of the movable holder includes a flange fitting part 31, an outer cylinder part holding part 32, a needle base stopper 33, and a peripheral surface holding part 34.

The flange fitting part 31 is fitted with the flange 86 of the syringe barrel 84. As shown in FIG. 3B, the flange fitting portion 31 has a wing-shaped outer frame shape in a top view, and is engaged by fitting the flange 86 into the outer frame shape. By this engagement, the flange 86 is positioned, and the flange 86 is restricted from moving in the separating direction (retracting direction, arrow B direction in FIG. 1B) with respect to the movable holder 30.

The outer cylinder part clamping part 32 holds the position of the outer cylinder part 85 of the injection cylinder 84 from both sides. The outer cylinder part clamping part 32 is a linear protrusion shape that stands up in a rib shape so as to extend along both sides of the side surface of the cylindrical outer cylinder part 85. With this structure, the outer cylinder part clamping part 32 regulates the lateral displacement of the outer cylinder part 85, that is, the lateral displacement in the movable holder 30. Even if the movable holder 30 moves, the holding state can be stably maintained.

The needle base stopper 33 restricts the movement of the needle base 82 of the injection needle 81. In the example of the syringe shown in FIG. 2, the tip of the needle base 82 has a predetermined surface shape, and the needle base stopper 33 shown in FIG. 3 is reduced in inner diameter (provided with a step). The tip end surface of the needle base 82 can be contacted.

In FIG. 3A, the needle base stopper 33 extends perpendicularly to the direction of stopping the moving direction of the syringe 80 and passes through the needle tube 83, but the tip of the needle base 82 (the surface perpendicular to the moving direction). ) Is in contact with the needle base stopper 33 to restrict the movement of the syringe 80 relative to the movable holder 30. The needle base stopper 33 does not have to be perpendicular to the direction in which the syringe 80 is moved. For example, the needle base 82 may be stopped by gradually reducing the shape of the circumference. Alternatively, when there is no vertical surface at the tip of the needle base 82 and the shape of the needle base 82 gradually increases in diameter toward the portion where the needle base 82 is connected, the needle base stopper 33 However, the movement of the syringe 80 relative to the movable holder 30 may be regulated by contacting the side surface of the needle base 82.

With this configuration, when the syringe 80 is attached to the injection device 1 and during the injection operation, the needle base 82 is in the direction close to the opening 11 side in the movable holder 30 (forward direction, FIG. 1B). ) In the direction of arrow A).

The peripheral surface holding portion (needle base peripheral surface holding portion) 34 holds the peripheral surface of the needle base 82 of the injection needle 81 in a peripheral shape. In addition, the peripheral surface holding part 34 may hold | maintain the front-end | tip of the outer cylinder part 85 of the injection cylinder 84 in the shape of a peripheral surface further. The circumferential surface holding portion 34 shown in FIG. 3 has a cylindrical shape that covers the entire circumferential surface along the circumferential surface direction of the tips of the needle base 82 and the outer cylindrical portion 85. The peripheral surface holding part 34 does not have to cover the entire periphery, and may be, for example, a shape that follows the shape of the tip of the needle base 82 and the outer cylinder part 85 along a semicircular shape. The circumferential surface holding portion 34 regulates lateral displacement of the needle base 82 and the outer cylinder portion with respect to the movable holder 30. With this configuration, when the movable holder 30 moves, movement (displacement) in the lateral direction (short direction) of the holding state can be prevented.

As described above, in the movable holder 30, the flange fitting portion 31 restricts the movement of the syringe cylinder 84 in the separating direction (the backward direction of the arrow B in FIG. 1B), and the needle base stopper 33 is used for the injection. By restricting the movement of the needle 81 in the proximity direction (the forward direction of arrow A in FIG. 1B), the coupling state of the syringe barrel 84 and the injection needle 81 is maintained in the movement direction.

Therefore, even when the syringe barrel 84 and the syringe needle 81 move together with the movable holder 30, it is possible to prevent the syringe needle 81 from coming off the syringe barrel 84 and leaking the contents into the syringe 1.

In addition, the outer cylinder part clamping part 32 of the movable holder 30 does not need to stand in all the parts along the outer cylinder part 85 of the syringe 80. As shown in FIG. 3A, by providing the flat surface portion 35 in which a part of the protrusion of the outer tube portion clamping portion 32 is interrupted, it is easy to fit the syringe 80 into the movable holder 30. The operability when attaching / detaching 80 is improved.

[Support mechanism]
The support mechanism 20 is demonstrated using FIG.4 and FIG.1 (b). 4A shows a perspective view of the contact head 10 and the support mechanism 20, and FIG. 4B shows a perspective view seen from another direction. (C) shows the arrow view seen from the injection | pouring direction of the contact head 10 and the support mechanism 20. FIG. The contact head 10 and the support mechanism 20 function as a fixed member (main body) that is immovable with respect to the movable holder 30 that is movable.

The support mechanism 20 is fixed to the contact head 10. The contact angle of the needle tube 83 of the syringe 80 with respect to the subject is set by the connection angle between the contact head 10 and the support mechanism 20.

The angle between the support mechanism 20 and the contact head 10 that defines the injection angle may be preferably 10 degrees to 90 degrees, but if it is within a range of 15 degrees to 25 degrees, Furthermore, it is more preferable.

The support mechanism 20 includes an upper surface cover 24 and a side wall 23, and a cylindrical holder guide path (insertion through hole) 21 that guides the movement of the movable holder 30 is formed inside the support mechanism 20. Here, an opening 23 </ b> O which is an entrance of an insertion hole of the holder guide path 21 into which the movable holder 30 is inserted is formed in the side wall 23 positioned at the rear end of the support mechanism 20.

The lower part of the holder guide path 21 that allows the movable holder 30 to move along the support mechanism 20 functions as a movement guide rail 22 that guides the movement of the movable holder 30.

(Below the support mechanism 20 is provided with a cut (opening) 25 extending in the lateral direction (injection direction)). Opening the lower portion prevents the tip of the needle tube 83 from coming into contact with the inside of the injection device 1 when the syringe 80 is attached or detached.

In the present embodiment, the movement guide rail 22 is a cylindrical insertion through-hole for inserting the tip of the movable holder 30 (at least the portion holding the injection needle 81), other than the lower surface of the inner peripheral surface of the holder guide path 21. This part has a shape along the shape of the tip of the movable holder 30 (peripheral surface holding part 34).

As shown in FIGS. 4A and 4C, in the support mechanism 20, the upper side and both sides of the holder guide path 21 are covered in a semicircular shape (kamaboko shape). Specifically, the support mechanism 20 is an upper surface cover that covers at least a portion (the needle base stopper 33 and the peripheral surface holding portion 34) that holds the injection needle 81 and the injection needle 81 of the movable holder 30 in the upper surface and the lateral direction. 24. Therefore, in the present embodiment, the support mechanism 20 has a housing shape in which a lower portion is opened and a holder guide path 21 which is a cylindrical insertion hole extending in the moving direction to guide the movable holder 30 is provided. Yes.

In this embodiment, the side wall 23 of the support mechanism 20 stops the movement (forward movement) of the movable holder 30 in the proximity direction to the contact head 10. That is, the end point of the slide movement is defined. Further, the front end of the guide bar 51 and the front end of the connecting bar 53 are fixed (connected) to the side wall 23 of the support mechanism 20. Specifically, the side wall 23 is provided with a side wall fixing portion 23G for fixing the guide rod 51 and a side wall fixing portion 23J for fixing the connecting rod 53 (see FIG. 5). As shown in FIG. 5, the side wall fixing portions 23G and 23J may include a fastening member for fastening the guide rod 51 and the connecting rod 53, an adhesive member for bonding, and the like.

Note that the cylindrical housing forming the holder guide path may be open at the top (the upper surface cover 24 may not be provided). For example, in the present embodiment, the support mechanism 20 defines, at a minimum, a movement guide rail 22 that moves and guides a part of the movable holder 30 (a part that holds the needle part) to the contact head 10 and an end point of the movement. It is sufficient if there is a side wall 23 that serves as a stopper.

However, as shown in FIGS. 4A and 4C, in the present embodiment, by providing the upper surface cover 24, it is possible to guide the tip of the movable holder 30 on the peripheral surface, so that the movement is further performed. Has the effect of stabilizing. In addition, / or safety and hygiene aspects of the operator can be taken into account.

[Content injection control mechanism]
5A is an exploded view showing the content injection control mechanism 50 of the present invention, and FIG. 5B shows the content injection control mechanism 50 and the moving support portion 330 on the lower surface of the movable holder 30. FIG. It is sectional drawing. Note that FIG. 5B corresponds to a cross-sectional view of the BB ′ plane in FIG.

The injection device 1 according to the embodiment of the present invention includes, as the content injection control mechanism 50, a pressing portion 40, a guide bar 51, an interlocking bar 52, a connecting bar 53, a coil spring (first elastic member) 54, 55.

The pressing unit 40 presses the pusher 88 against the inside of the syringe barrel 84 held by the movable holder 30.

The guide rod 51, the interlocking rod 52, and the connecting rod 53 are rod-shaped members that control the relative movement of the movable holder 30. The guide rod 51 is engaged with the movable holder 30 and the pressing portion 40 so as to be relatively movable.

The interlocking rod 52 is fastened to the movable holder 30 and is movably engaged with the pressing portion 40. The connecting rod 53 extends in the same straight line as the interlocking rod 52, and the end portion (rear end) faces the end portion (front end) of the interlocking rod 52 and can be contacted / separated. Further, the tip of the connecting rod 53 is located inside the movable holder 30.

Further, as shown in FIG. 5 (b), the first elastic members (coil springs) 54 and 55 are provided inside the movable holder 30.

The lower part of the movable holder 30 shown in FIG. 5B shows a moving support part 330 provided at the lower part of the part for holding the syringe barrel 84.

In the movement support portion 330, a first through hole 331 through which the guide rod 51 is slidably inserted, and a connecting rod 53 is slidably inserted at the tip, and the interlocking rod 52 is fastened to the rear end on the same straight line. The second through hole 332 is formed.

The guide rod 51 and the connecting rod 53 are movable with respect to the through holes 331 and 332 of the movable holder 30 respectively.

The interlocking rod 52 is fixed to the through hole 332 of the movable holder 30 at a predetermined position by the adhesive member 38.

When the movable holder 30 moves in the proximity direction to the contact head 10, a coil spring (first elastic member) provided in the movable holder 30 from the guide rod 51 and the connecting rod 53 with respect to the first elastic member. Compressive force is applied to the members 54, 55.

The pressing part 40 is engaged with the guide bar 51 and the interlocking bar 52. The pressing portion 40 is a pusher pushing portion that abuts against the head (rear end portion) 88h of the pusher 88 and pushes the pusher 88 by relative movement. The distance between the movable holder 30 and the contact head 10 and the distance between the movable holder 30 and the pressing portion 40 are changed by the restoring force of the coil springs 54 and 55 provided on the movable holder 30. Details of the change in the distance will be described later with reference to FIGS.

Here, when the moving distance of the movable holder 30 is constant, the compressive force applied to the coil springs 54 and 55 is constant. Therefore, when a predetermined amount of content is divided into a plurality of times and the injection amount is equal each time, the moving amount of the movable holder 30 becomes constant, so that the compression force and the subsequent restoring force of the coil springs 54 and 55 are obtained. Is constant, so that the injection operation can be performed at the same injection speed each time.

On the inner walls of the through holes 331 and 332 through which the rod-shaped members 51, 52, and 53 are provided, the protrusions 36 and 37 (that is, the portions having small diameters in the through holes 331 and 332) are provided. As a spring holding member, it is provided.

The guide rod 51 and the connecting rod 53 are each provided with a small diameter portion and a large diameter portion. The small diameter portions 51S and 53S are located near the center of the movable holder 30 in the extending direction of the guide rod 51 and the connecting rod 53, and the large diameter portions 51F and 53F are on the support mechanism 20 side (tip side) of the movable holder 30. Located in.

The coil springs 54 and 55 are fitted on the small diameter portions 51S and 53S of the guide rods 51 and 53, respectively. The guide bar 51 on which the coil spring 54 is fitted is fitted in the through hole 331. The connecting rod 53 to which the coil spring 55 is fitted and the fixed interlocking rod 52 are fitted in the through hole 332.

The leading end of the coil spring (first elastic member) is held by the side surface (stepped portion) of the guide rod 51 and the connecting rod 53 that is reduced in diameter from the large diameter portions 51F and 53F to the small diameter portions 51S and 53S, and the rear end is the spring. The protrusions 36 and 37, which are holding members, are held on the protrusion side surfaces 36S and 37S.

The guide bar 51 and the connecting bar 53 are configured to be split so that the coil springs 54 and 55 can be fitted onto the small diameter portions 51S and 53S.

Inside the movable holder 30, the end of the connecting rod 53 has a large diameter, and the large-diameter end 53T at the end can be separated from other parts. For example, a screw groove and a screw groove can be formed. Fastened by fitting. Here, the position where the step between the large-diameter end 53T and the small-diameter portion 53S at the end of the connecting rod 53 comes into contact with the surface of the protrusion 37 on the pressing portion 40 side and is caught is the distance between the movable holder 30 and the support mechanism 20. , The farthest position.

Further, in the guide rod 51, it is preferable that the pressing portion 40 side is designed to be close to the diameter of the through hole 331 and larger than the small diameter portion 51S (provided with a medium diameter portion 51M). When compressive force is applied to the coil springs 54 and 55 so as to move the needle tube 83 and when the spring is restored, even if the engagement of the ratchet mechanism to be described later is changed, the medium diameter portion 51M remains in the through hole. This is because the support mechanism 20 can be moved relative to the guide bar 51 more smoothly because it moves along 332.

Here, the movable holder 30 is a distance away from the support mechanism 20 D2 (distance _{D m} to be described later) is before the start of the puncture, the distance D1 between the interlocking rod 52 and connecting rod 53, the corresponding. This distance sets the injection depth of the injection needle.

Here, the injection depth of the needle tube 83 of the injection needle 81 is preferably in the range of 0.5 to 5.5 mm, and more preferably in the range of 2.0 mm to 3.5 mm.

[Pressing part]
FIG. 6 is an explanatory diagram of the ratchet mechanism in the pressing portion 40. Specifically, an exploded view of the pressing portion 40 is shown.

In the guide bar 51 and the interlocking bar 52, engaging racks 51r and 52r having inclinations are formed on the peripheral surface of the part that can face the pressing portion 40.

The pressing portion 40 includes pawls (plate springs) 41 that mesh with the engagement racks of the guide bar 51 and the interlocking bar 52. In addition to the pawl, the pressing portion 40 is provided with a leaf spring support bar 42 to which the pawl 41 is fixed and a case portion 44 that covers the pawl 41. The leaf spring support rod 42 is movably attached to a support plate 45 fixed to the pressing portion 40. Further, a button 42h is provided on the opposite side to which the pawl 41 is fixed, and a compression coil spring 43 is externally fitted between the button 42h and the support plate.

Here, the engagement configuration between the pawl 41 in the pressing portion 40 and the engagement racks 51r and 52r of the guide rod 51 and the interlocking rod 52 is a ratchet mechanism. In other words, the pressing portion 40 can move relative to the guide rod 51 and the interlocking rod 52 in a direction approaching the movable holder 30, and move in a direction away from the movable holder 30 in a relatively separating direction (retracting direction). The movement is locked.

When the locking of the position of the pressing portion 40 is released, such as when the syringe 80 is attached or detached, the button 42h is pressed against the coil spring 43, so that the engagement between the pawl 41 and the engagement racks 51r and 52r is achieved. The match is released. Details will be described later with reference to FIGS.

[Contact head]
FIG. 7 is an enlarged view of the contact head 10. As shown in FIG. 7, the contact head 10 has an upper surface 13, a side surface 14, and a lower surface 12. The shape of the upper surface 13 and the lower surface 12 of the contact head 10 is circular, horseshoe-shaped, or polygonal.

7A to 7C, the opening 11 penetrates the upper surface 13 and the lower surface 12 of the contact head 10. Moreover, the needle | hook can pass through the opening part 11. FIG. That is, the opening 11 of the contact head 10 penetrates the lower surface 12 of the contact head 10 in a bifurcated direction in which the needle tube 83 passes and the vertical direction of the contact head 10 as the movable holder 30 moves. Yes.

With reference to the side cross-sectional view of FIG. 7A, the lower surface 12 of the contact head 10 is positioned such that the surface 12 c around the opening 11 is located inside the other lower surface (for example, the lower surface protrusion 12 e). It is configured. If the lower surface 12 is configured in this way, when the contents are injected into the subject, the lower surface 12 partially contacts the subject, and the periphery of the opening 11 is not in contact with the subject.

For example, as a case of non-contact, in the embodiment shown in FIG. 7C, the lower surface protrusion that continuously protrudes in the surface direction of the lower surface on the circumferential portion that is the edge of the lower surface of the circular contact head 10 12e is formed. The top part of the circumferential lower surface protrusion 12e abuts on the subject so as to surround the periphery of the opening 11. The lower surface protrusion 12e is not limited to a continuous shape, and may be an intermittent shape such as a leg shape.

By configuring the lower surface 12 of the contact head 10 in this way, a predetermined space is provided between the periphery of the opening 11 and the subject. Accordingly, when a liquid such as leaked liquid or blood flows out from the subject during the injection operation, the liquid comes into contact with the lower surface of the contact head 10 around the opening 11, so that the liquid spreads on the lower surface 12. To prevent adhesion.

Furthermore, the needle tube 83 is configured such that the tip of the needle tube 83 is positioned above the portion of the lower surface 12 of the contact head 10 that contacts the subject before the puncture operation and after the needle extraction operation.

Specifically, the needle tube 83 of the syringe applied to the injection device of the present invention is such that the tip of the needle tube 83 is positioned above the portion of the lower surface of the contact head 10 that contacts the subject before the puncture. In addition, the length of the needle tube 83 is selected and used.

For example, the injection volume may be different at each separate injection site at a separate injection depth. The injection length range defines the length of the injection path during the retracting operation of the injection needle. Therefore, it is foreseen that the total injection length is determined by the length of the injection needle. The total injection length of the injection needle is preferably 2.0 mm to 50 mm, and more preferably 5.0 mm to 40 mm.

Thus, before the puncture operation and after the needle extraction operation, the tip of the needle tube 83 of the injection needle 81 does not contact the subject, so that the subject is stuck with the needle tube 83 when the injection device is separated from the subject. Therefore, it can be prevented from moving in an unexpected direction. Therefore, the safety of the injection device is improved.

Furthermore, in the operation, while improving the stability of the contact with the subject during the operation, in the contact head 10 on the lower surface 12, the space where the opening 11 and the subject are not in contact is increased. A collar portion 16 protruding from the side surface 14 may be provided.

Referring to FIG. 7 (b), the opening 11 has an elongated hole shape that is elongated from the position corresponding to the injection point toward the support mechanism 20 on the upper surface.

As described above, the shape of the opening 11 seen from above is formed in the shape of a long hole as described above, so that when performing the injection operation, the injection direction is clarified and the operator's needle tube for the injection operation is visually recognized. Longer possible time. By clarifying the injection direction, the injection operation can be performed at a more accurate position with respect to the target injection point. Further, since the visible time of the needle tube becomes longer, it can be discovered before the injection operation is started when there is an abnormality such as bending or cutting in the needle tube 83. Therefore, it is possible to prevent an abnormal injection operation on the subject in advance.

Further, on the lower surface 12 of the contact head 10, the lower surface 12 of the contact head 10 from the portion penetrating in the vertical direction as the opening 11 in the passing direction of the needle tube 83 accompanying the movement of the injection needle toward the support mechanism 20. A notch shape is provided to reach the edge. Further, in the lower part of the support mechanism 20, a space between the two movement guide rails 22 is opened and a cut shape is provided. As described above, since the lower portions of the support mechanism 20 and the contact head 10 are opened, the needle tube 83 can be prevented from coming into contact with any portion when the syringe 80 is detached.

Further, in the present embodiment, the upper surface 13 of the contact head 10 is preferably a mortar shape or a semicircular shape recessed inward so as to constitute a magnifying glass. If the upper surface is configured with a magnifying glass, the injection site can be easily visualized. For example, even when it is difficult to view directly due to the influence of a light source or the like, it is possible to inject while visually checking the opening 11 and the needle tube 83 passing through the opening 11 by using a magnifying glass. .

In order to improve the effect of the magnifier, the position corresponding to the injection point in the opening 11 on the upper surface is preferably the center of the lower surface (upper surface). Further, even if the opening 11 is a long hole, a mark 17 may be provided near the center so that the injection point can be easily changed.

Further, a linear notch serving as a positioning groove 15 is formed on the side surface 14 of the contact head 10. This linear incision is used for visually recognizing the mark on the subject at the stage of injection preparation described later. Since the positioning groove 15 formed on the side surface 14 as a notch for visually recognizing the mark is linear, it is easy to align the mark and the contact head 10 in the execution procedure described later. Further, when the cut is linear, there is an advantage that the surface processing becomes easy.

[Injection operation]
FIG. 8 is an operation explanatory diagram of the injection device 1 according to the first embodiment. FIG. 9 is an explanatory diagram of an injection operation flow according to the first embodiment. The injection operation in the first embodiment will be described with reference to FIGS. 8 and 9 below.

In this embodiment, the content injection control mechanism 50 controls the needle tube 83 to withdraw the needle tube 83 from a desired depth to the subject surface at the same time that the content is injected into the subject. The following flow will be described.

START: A syringe filled with an infusion is set in an injection device. At this time, it sets to a starting position so that the pusher 88 and the press part 40 may contact. (See the implementation procedure below)
As a premise, the contact head 10 of the injection device 1 is brought into contact with the subject S at the start. Before the puncturing operation, each component of the injection device 1 is assumed to be in the state shown in FIG. Note that due to the shape of the lower surface of the contact head 10 shown in FIG. 7A, the tip of the needle tube 83 is positioned above the portion of the lower surface of the contact head 10 that contacts the subject before the puncture. Therefore, the tip of the needle tube 83 does not contact the subject.

S1: The operator manually brings the movable holder 30 close to the contact head 10 (puncture operation). At this time, the movable holder 30 moves in the proximity direction to the contact head 10 (the direction indicated by the arrow), so that the needle tube 83 of the injection needle 81 comes close to the subject and punctures the subject. Move forward into (enter). Here, the coil springs (first elastic members) 54 and 55 provided in the movable holder 30 are compressed.

Specifically, with interlocking rod 52 fastened to the movable holder 30, the pressing portion 40, while keeping the movable holder 30 a predetermined distance D _p, and moved in the direction approaching to the contact head 10, the distance D _m is short (Becomes zero) (FIG. 8 (a) → FIG. 8 (b)). Here, since the interlocking rod 52 fastened with the movable holder 30 moves together with the movable holder 30, the pressing portion 40 and the end of the interlocking rod 52 also move together.

Also, since the pressing portion 40 moves relative to the guide rod 51 that does not move, the fitting portion between the guide rod 51 and the pressing portion 40 slides relatively in the forward direction (movable holder 30 side).

The relative movement of the pressing portion 40 does not change the distance between the movable holder 30 and the pressing portion 40 in the puncturing operation. Therefore, it is possible to prevent air bubbles generated due to decompression of only the pusher 88 moving backward due to an increase in the distance between the movable holder 30 and the pressing portion 40. Further, since the distance between the movable holder 30 and the pressing portion 40 is shortened, it is possible to prevent only the pusher 88 from moving forward and performing the injection operation in parallel with the puncturing operation.

In S <b> 2, when the operator removes his / her hand from the movable holder 30 and moves in the direction away from the contact head 10, the needle tube retracts from the inside of the subject, removes the needle from the subject, and moves away from the subject. .

Specifically, when the forward force applied to the movable holder 30 is released, the movable holder 30 is supported by the restoring force of the coil spring (first elastic member) 54 provided on the movable holder 30. Move away from 20

Here, the pressing portion 40 is locked by a ratchet mechanism (FIG. 6) relative to the rod- like members 51 and 52 in the movement in the separating direction (retracting direction). That is, when the movable holder 30 moves away from the contact head 10, the pressing portion 40 is stopped together with the unfastened guide rod 51 that does not move, so that the movable holder 30 is not moved against the pressing portion 40 that does not move. The interlocking rod 52 fastened to the position moves. That is, the pressing portion 40 slides toward the movable holder 30 (forward direction) with respect to the interlocking rod 52.

The operation by the distance D _m becomes long, the distance D _p that is shorter, performing the needle removal and liquid injection together (FIG. 8 (b) ⇒ (c) ). As the movable holder 30 moves backward, the movable holder 30 moves relative to the guide rod 51, so that the distance between the movable holder 30 and the pressing portion 40 is shortened. When the distance between the pressing part 40 and the movable holder 30 is shortened (D _p ⇒D _p ′), the pusher 88 is pushed into the syringe cylinder 84, and the volume of the syringe cylinder 84 becomes small, and the inside Liquid is injected into the subject. Therefore, an appropriate amount of injection operation can be appropriately performed.

END: The injection device 1 is separated from the subject. At this time, the tip of the needle tube 83 is separated from the subject due to the shape of the lower surface of the contact head 10 in FIG.

With the above configuration and flow, the injection device 1 of the present invention appropriately holds the syringe cylinder 84 and the injection needle 81 in the movable holder 30 when the injection operation is performed. In particular, the flange fitting portion 31 and the needle base stopper 33 restrict the movement of the syringe cylinder 84 and the injection needle 81 in the content injection direction.

Therefore, even when a highly viscous gel-like substance is used as the contents to be injected by injection, even if a high pressure is applied to the syringe barrel during use, the connection state between the syringe needle and the syringe barrel is not canceled. Therefore, a precise injection operation can be realized by the injection device 1.

Second Embodiment
Next, a second embodiment will be described. The injection device of the second embodiment is preferably applied when an injection operation is performed on a very shallow place of the subject.

In the injection device according to the second embodiment, after the puncturing operation, the needle moves backward (withdrawing needle) in two stages. Specifically, in conjunction with the injection operation (contents injection operation) by the pressing operation of the pusher onto the syringe barrel, the needle is retracted to a predetermined distance (needle removal operation), and then the injection operation is not performed. In addition, an operation is performed in which the needle retracts from the predetermined distance until the needle is removed from the surface of the subject.

FIG. 10 is an explanatory view of an injection device 2 according to the second embodiment of the present invention, in which (a) is a perspective view and (b) is a side view. FIG. 11 shows an enlarged view of the needle extraction control mechanism of the injection apparatus of FIG. FIG. 12 shows a perspective view of the injection device of FIG.

As shown in FIG. 10 to FIG. 12, the injection device 2 of this embodiment includes a needle removal control mechanism 60. In the present embodiment, the content injection control mechanism 50 controls the first-stage needle tube retraction operation in which the content is injected into the subject and the needle tube is retracted from a desired depth to a predetermined position. The needle removal control mechanism 60 controls the second-stage needle tube retraction operation in which the needle tube is retracted from a predetermined position to at least the surface of the subject and the needle is removed without injecting the contents into the subject.

Referring to FIG. 11, the needle removal control mechanism 60 includes a control plate 61, two position adjustment pins 62, 63, two coil springs (second elastic members) 64, 65, a lock pin 66, 67.

The control plate 61 includes an upper surface plate 61T and a side surface plate 61S that cover at least a part of the upper surface portion 24-1 of the support mechanism 20-1 and the side wall 23-1 on the rear end side away from the contact head 10. Prepare.

The two position adjustment pins (dowels) 62 and 63 have large-diameter heads and are fitted in the side plates 61S of the control plate 61.

The coil springs 64 and 65, which are second elastic members, are provided (externally fitted) on the outer periphery of the position adjustment pin, and are held by the side plate 61S of the control plate 61 and the support mechanism 20-1.

The two lock pins (elastic pins) 66 and 67 are provided on the upper surface of the support mechanism 20-1, and one end is held by the side surface (guide surface) of the circumferential surface holding portion 34-1 of the movable holder 30-1. . The lock pins 66 and 67 are provided to extend in a direction substantially perpendicular to the moving direction of the syringe 80 (short direction of the syringe barrel).

Further, in the present embodiment, the engagement protrusion 39 is provided on the upper surface of the peripheral surface holding portion 34-1 of the movable holder 30-1. The tip of the engaging protrusion 39 has a tapered shape, and the lock pins 66 and 67 are slidably in contact with the vertical surfaces (holder side guide surfaces) 39L and 39M of the protrusion tip.

The support mechanism 20-1 includes an upper surface portion 24-1 and a side wall 23-1, and a guide path for guiding the movement of the movable holder 30-1 is formed therein. As in the first embodiment, the side wall 23-1 of the support mechanism 20-1 is opened so that a part of the movable holder 30-1 is inserted (opening 23O).

Here, the shape of the support mechanism 20-1 is different from that of the first embodiment, and is a recessed shape for fitting the upper surface plate 61T of the control plate 61 into the upper surface portion 24-1 of the support mechanism 20-1. A notch 26 is provided. Lock pins 66 and 67 are slidably in contact with vertical surfaces (support side guide surfaces) 27L and 27M in the moving direction of the notch 26.

Further, recessed portions with respect to the vertical surfaces 27L and 27M, that is, grooves 28L and 28M are formed, respectively, in which the space of the notch is increased.

The lock pins 66 and 67 are elastic pins that can be extended and contracted, and slide along the holder side guide surfaces 39L and 39M of the movable holder 30-1 and along the grooves 61TL and 61TM cut in the upper surface plate 61T. Is possible.

When performing the injection operation, the holder-side guide surfaces 39L and 39M are not yet in contact with the lock pins 66 and 67 in the state shown in FIG. When the movable holder 30-1 is moved in this state, the lock pins 66 and 67 start to contact the tips of the holder side guide surfaces 39L and 39M, and then move along the holder side guide surfaces 39L and 39M (see FIG. 11, left direction).

Immediately before the state shown in FIG. 13B, the lock pins 66 and 67 are pushed outward by the shape of the engaging protrusion 39 which is the convex portion of the movable holder 30, and engage with the grooves 28L and 28M. (FIG. 11 (a) → FIG. 11 (b)). After engaging with the grooves 28L and 28M, the control plate 61 and the movable holder 30-1 further move, and the grooves 61TL and 61TM of the upper surface plate 61T of the control plate 61 move relative to the lock pins 66 and 67. (FIG. 13 (b) → FIG. 13 (c)).

When the operator releases the hand, first, the movable holder 30-1 moves with the lock pins 66 and 67 engaged with the grooves 28L and 28M (FIG. 13 (c) → FIG. 13 (d)). . When the predetermined position is reached, the outward pushing force applied to the lock pins 66 and 67 due to the shape of the holder-side guide surfaces 39L and 39M of the engaging projection 39, which is the convex portion of the movable holder 30-1, is applied. As a result, the lock pins 66 and 67 and the grooves 28L and 28M are disengaged (FIG. 11B).

Then, the restoring force of the coil springs 64 and 65, which are the second elastic members, acts, and the control plate 61 and the movable holder 30-1 move together (FIG. 11 (b) → FIG. 11 (a), FIG. 13 (d) ⇒13 (e)), the reverse operation is completed. At this time, the lock pins 66 and 67 that have been disengaged slide along the vertical surfaces (support side guide surfaces) 27L and 27M.

Further, unlike the first embodiment, the present embodiment is not provided with side wall fixing portions 23G and 23J for fixing the guide rod 51 and the connecting rod 53 to the side wall 23-1 of the support mechanism 20-1. . Instead, the pin insertion holes 23P and 23Q into which the position adjusting pins 62 and 63 into which the second elastic members 64 and 65 are fitted to the outside are movably inserted are opened.

The side plate 61S of the control plate 61 is opened so that a part of the movable holder 30-1 is inserted. In the present embodiment, the distal end of the guide rod 51-1 and the distal end of the connecting rod 53-2 are fixed to the side plate 61S of the control plate 61. The side plate 61S is provided with a side fixing portion 61SG that fixes the guide rod 51 and a side fixing portion 61SJ that fixes the interlocking rod 52 (see FIG. 12).

The side plate 61S of the control plate 61 has side plate pin insertion holes 61SP and 61SQ into which the position adjusting pins 62 and 63 into which the second elastic members 64 and 65 are fitted are movably inserted. It is open.

By the puncturing operation, the side plate 61S of the control plate 61 comes into contact with the side wall 23-1 of the support mechanism 20-1. In the first stage of the needle tube retraction operation, the movable holder 30-1 is retracted while the side plate 61S of the control plate 61 is in contact with the side wall 23-1 of the support mechanism 20-1. In the second-stage needle tube retraction operation, the side plate 61S of the control plate 61 moves away from the side wall 23-1 of the support mechanism 20-1, and the movable holder 30-1 retracts.

[Injection operation]
FIG. 13 is an operation explanatory diagram of an injection operation according to the second embodiment. FIG. 15 is an explanatory diagram of an injection operation flow according to the second embodiment. The injection operation in the second embodiment will be described below with reference to FIGS. 13 and 14.

START: As a premise, the injection point and the mark are marked on the subject using the injection template 100 (see FIG. 16), and then the syringe 80 (see FIG. 3) is set in the injection device 2. The contact head 10-1 of the injection device 2 is brought into contact with the subject.

<Needle tube forward movement>
In S11 of FIG. 14, the operator manually brings the movable holder 30-1 closer to the contact head 10 (puncture operation). When the movable holder 30-1 moves a predetermined distance in the proximity direction to the contact head 10-1, the first elastic members 54, 55 are moved from the guide bar 51-1 and the connecting bar 53-2 to the first. A compressive force is applied to the elastic members 54 and 55, and the position adjusting pins 62 and 63 move in the proximity direction to the contact head 10-1 together with the movable holder 30-1. That is, in FIG. 13, the distance _{D P} and the distance _{D L} is not leave distance _{D M} is shortened Henra (zero), the compressive force is applied to the first elastic member 54, 55 (FIG. 13 (a) (B)).

When the predetermined position is reached, the lock pins 66 and 67 engage with the grooves 28L and 28M of the support mechanism 20.

Thereafter, the position adjustment pins 62 and 63 and the control plate 61 move in the direction of the abutting head 10-1 (forward movement direction) in a state where the lock pins 66 and 67 are fitted in the grooves of the support mechanism 20-1. In other words, the distance D _L is shortened (becomes zero) while the distance D _M remains zero and the distance D _P remains unchanged, and a compressive force is applied to the second elastic members 64 and 65 (FIG. 13). (B) ⇒ (c)).

<Needle tube retraction>
As S12 in FIG. 14, the operator releases his hand from the movable holder 30-1. When the movable holder 30-1 no longer applies a force in the proximity direction to the contact head 10-1, as a first step, the position adjusting pins 62, 63 and the lock are restored by the restoring force of the first elastic members 54, 55. The positions of the pins 66 and 67 are not changed, and the movable holder 30-1 moves in the direction away from the support mechanism 20-1 and in the direction closer to the pressing unit 40, thereby injecting the contents into the subject. The needle tube 83 is retracted from a desired depth to a predetermined position. In other words, while the distance DI is not changed, the distance _{D M} is increased, the distance _{D P} becomes shorter _{(D P} ') that is, the retraction of a predetermined distance, the injection operation is carried out (FIG. 13 (c) ⇒ ( d)).

As the second-stage backward movement operation of S13 in FIG. 14, the lock pins 66 and 67 are released (released from the fitted state), and the positions of the position adjustment pins 62 and 63 and the control plate 61 are moved. Due to the restoring force of the elastic members 64 and 65, the pressing portion 40 fitted to the movable holder 30-1, the guide bar 51, the connecting bar 53 and the interlocking bar 52 that are in contact with each other moves. That is, the distance D _M is not changed, the distance D _P ′ is not changed, and the distance D _L is increased, so that the needle tube 83 is retracted from a predetermined position until the needle is removed from the subject without an injection operation. (FIG. 13 (d) ⇒ (e)).

With the above configuration and flow, when the injection operation of the injection device 2 of the present invention is performed, the syringe barrel 84 and the injection needle 81 are appropriately held in the movable holder 30-1. In particular, the flange fitting portion 31 and the needle base stopper 33 restrict displacement of the syringe barrel 84 and the injection needle 81 in the moving direction when the contents are injected.

Therefore, even when a highly viscous gel-like substance is used as the contents to be injected by injection, even if a high pressure is applied to the syringe cylinder during use, the connection state between the injection needle 81 and the syringe cylinder 84 is eliminated. Not. Therefore, a precise injection operation can be realized by the injection device 2.

Furthermore, in this embodiment, the needle moves backward in two stages, so that the needle is removed after the injection operation is completed. Therefore, when a very small amount of valuable contents such as cells are injected into a very shallow place of the subject, the injection operation can be performed without overflowing the injected content from the surface of the subject.

[Apply procedure]
In order to determine the injection site and injection direction, the center hole of the injection template 100 is aligned with the center of the injection site before injection (FIG. 15 (b)), and aligned with the six vertically long holes with a sterilized oil pen A mark is made (FIG. 15C). If you want to inject repeatedly over the same site, mark the site with an art make dye. When injecting into hairy parts such as the scalp, the area around the injection site is clipped in advance. Before injection, the area around the injection site is disinfected and dried, and then anesthetized.

The syringe 80 is taken out of the package, and the injection solution is filled into the syringe cylinder 85. In order to set the syringe 80 to the injection device 1, the button 42h at the rear end of the pressing portion 40 is pushed and slid to the rearmost end opposite to the contact head 10 (FIG. 16A).

Injecting device 1 while taking care not to bring the needle tip (the tip of the needle tube) into contact with the main body 10, 20 of the injection device 1, etc. The movable holder 30 is attached. Specifically, as shown in FIG. 16B, the syringe 80 is inserted obliquely from the needle tip, and the flange (wing) 86 of the syringe barrel 84 is raised and pushed horizontally (FIGS. 16C and 16D). Then, the flange 86 is rotated to engage with the flange fitting portion 31 (FIG. 16 (e)). Thereafter, the pressing portion 40 of the injection device 1 is slowly moved until it comes into contact with the head 88h of the pusher 88 to complete the preparation. (FIG. 16 (f), FIG. 16 (g)).

Using the injection device 1 (FIG. 17 (a)) to which the syringe 80 is attached, the positioning groove of the contact head 10 and the mark attached with a sterilized oil pen are aligned. In this state, the contact head 10 is firmly pressed against the scalp (FIG. 17B, START in FIG. 8).

In this state, the movable holder 30 is manually pushed into the contact head 10 side, and the needle tube 83 of the injection needle 81 that moves together with the movable holder 30 is punctured into the scalp (corresponding to S1 in FIG. 8). At this time, it is confirmed from above that the needle tube 83 is punctured into the scalp by visually recognizing the elongated hole-like opening 11 at the center of the contact head 10.

Then, the preparation is injected into the scalp by slowly releasing the hand from the movable holder 30 of the injection device 1 (corresponding to S2 in FIG. 8). Then, after the injection operation is completed, the injection device 1 is separated from the scalp (corresponding to END in FIG. 8).

When injecting a plurality of times in different directions from the same injection site, the oil pen on the skin and the groove 15 provided around the contact head 10 are aligned in different directions and the above injection operation is repeated. By repeating this at 6 locations with the injection marks, a total of 1.0 mL of the test preparation is injected when a 1 mL syringe is used.

After use, the injection device 84 is removed from the syringe 84 and the needle 81, discarded, cleaned and maintained, and packed in a separate sterilization bag for sterilization. Sterilization can be any of autoclave, EO gas, gamma ray sterilization, and the like.

Here, with the above-described configuration, since the syringe 84 and the injection needle 81 are kept connected in the injection devices 1 and 2 during the period of performing the injection operation, the contents are mostly inside the injection devices 1 and 2. It is thought that it will not leak. Accordingly, it is sufficient for the cleaning and sterilization process to be performed with a focus on the lower surface 12 of the contact head 10, and the injection device to which the syringe is attached as compared with the conventional injection device in which the syringe barrel is expected to be attached and detached. There is little need to consider the contamination inside.

The content (substance) used in the injection device according to the above-described embodiment of the present invention is selected from the group consisting of a cell suspension, a gel material, a therapeutic substance, a cosmetic substance, and a diagnostic substance. sell. For example, the content (substance) used in the injection device can be selected from the group consisting of cell suspensions, gel-like materials, therapeutic substances, cosmetic substances, and diagnostic substances.

The cosmetic substance to be injected may include, but is not limited to, fat cells such as filler, hyaluronic acid, or botulinum toxin (Botox, Btx) in acupuncture. The therapeutic agent may include, but is not limited to, antibiotics, anesthetics, analgesics, vaccines, antibodies.

Furthermore, the injection device of the present invention may be used for injecting cells in a suspension or cells in a liquid medium into a subject as contents contained in a syringe.

Furthermore, a cell suspension may be mixed with a growth factor as the contents contained in the syringe. Alternatively, the cell suspension may contain a gel structure. Such a gel-like structure preferably represents a mixture of extracellular matrix proteins that mimic the extracellular environment of separate tissues, more preferably a gel-like structure such as hyaluronic acid.

Furthermore, the injection device according to the embodiment of the present invention may be used to inject a substance into a separate tissue of a subject. In particular, the injection device is used to inject cells into the skin as a cell suspension in the treatment of hair loss, alopecia such as alopecia areata, or other conditions associated with hair loss or too little hair Can be.

Also, the injection device of the present invention is preferably used for injecting a liquid such as a drug, cytokine, or growth factor into a subject. This application of the liquid to the subject is preferably done in connection with the treatment of hair loss, alopecia such as alopecia areata, or other conditions associated with hair loss or too little hair.

Alternatively, the injection device according to the embodiment of the present invention may be used for injecting a substance into the subject's muscle or injecting a substance into the subject's tendon.

Furthermore, the subject to which the injection device according to the embodiment of the present invention is applied is not limited to a human (subject), and may be an animal such as a fish or a mouse. Alternatively, the subject may be a tissue such as a skin or an organ taken out from the subject or the test subject animal.

The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific embodiments described above, and various modifications are possible within the scope of the gist of the present invention described in the claims. It can be modified and changed.

This international application claims priority based on Japanese Patent Application No. 2006-084281 filed on April 20, 2016, the entire contents of which are incorporated herein by reference.

DESCRIPTION OF SYMBOLS 1, 2, Injection device 10, 10-1 Contact head 11 Opening part 12 Lower surface 12c Lower surface center part 14 Side surface 15 Marking groove | channel 16 Collar part 20, 20-1 Support mechanism 21 Holder guide path | route (insertion hole)
22 Movement guide rail 23 Side wall 23O of support mechanism Opening 24 Upper surface cover 25 of support mechanism Lower surface notch opening 30 and 30-1 of support mechanism Movable holder 31 Flange fitting part 32 Outer cylinder part clamping part 33 Needle base stopper 34 circumference Surface holding portion 35 Flat portion 36, 37 Projection (spring holding member)
36S, 37S Projection side surface 38 Adhesive member 310 Front holder 320 Rear holder 330 Movement support portion 331 First through hole 40 Pressing portion (injection control mechanism)
41 Pawl (leaf spring)
42 Leaf spring support bar 42h Button 43 Pressing part spring 44 Cover 51, 51-1 Guide bar 51r Engagement rack 52 Interlocking bar 52r Engagement rack 53, 53-1 Connection rod 53T Large diameter end 54, 55 coil of connection rod Spring (first elastic member)
80 Syringe 81 Injection needle 82 Needle base 83 Needle tube 84 Syringe (syringe)
85 Outer tube portion 86 Flange 87 Tube tip 88 Pusher (plunger)
88h Pusher head 89 Gasket 60 Control mechanism 61 Control plate 61S Control plate side plate 61SG, 61SJ Side plate fixing part 61SP, 61SQ Side plate pin insertion hole 61T Control plate top plate 62, 63 Movement adjustment pins 64, 65 Coil Spring (second elastic member)
66, 67 Lock pin 23P, 23Q Pin insertion hole 24-1 Upper surface portion 26 of support mechanism Notch portion 27L, 27M Vertical surface (support side guide surface)
28L, 28M Groove 39 Engaging projection 39L, 39M Vertical surface (holder-side guide surface)
100 template for injection

Claims (23)

1. The subject is injected with contents by a syringe having a pusher, a syringe barrel into which the pusher is inserted, and a needle base connected to the syringe barrel and a needle tube punctured into the subject. An injection device,
   An abutting head capable of abutting against a subject and having an opening through which the needle tube passes;
   A movable holder for holding the syringe barrel and the injection needle;
   A support mechanism fixed to the contact head;
   A content injection control mechanism for pushing the pusher into the syringe barrel, and
   By moving the movable holder along the support mechanism, the syringe barrel and the injection needle are moved with respect to the contact head,
   The injection device is detachable from the injection device.
2. The content injection control mechanism includes a pressing portion that pushes the pusher into the syringe barrel,
   By moving the movable holder in the forward direction approaching the contact head, the needle tube is punctured into the subject and entered into the subject,
   By moving the movable holder in the retracting direction away from the contact head, the movable holder approaches the pressing portion while retracting the needle tube with respect to the subject, and the pusher is moved into the syringe barrel. The injection device according to claim 1, wherein the content is injected into the subject by pushing in the.
3. The syringe barrel includes an outer cylinder portion that contains the contents, and a flange provided at a rear end of the outer cylinder portion,
   The movable holder includes a flange fitting portion that is held by fitting with the flange, and the flange fitting portion regulates movement of the flange in the backward direction with respect to the movable holder. The injection device according to claim 2.
4. The movable holder includes an outer cylindrical portion clamping portion that sandwiches and holds the outer cylindrical portion by protrusions that stand along both sides of the side portion of the outer cylindrical portion, and the outer cylindrical portion clamping portion includes the movable holder. The injection device according to claim 3, wherein a lateral displacement of the outer cylinder portion with respect to the inner side is restricted.
5. The movable holder is provided with a needle base stopper that stops and holds the movement of the injection needle by a protrusion that contacts the vicinity of the tip end of the needle base, and the needle base stopper is located on the needle base with respect to the movable holder. The injection device according to claim 2, wherein movement in a forward direction is restricted.
6. The movable holder includes a peripheral surface holding portion that holds the needle base in a circumferential shape, and the peripheral surface holding portion regulates a lateral displacement of the needle base with respect to the movable holder. The injection device according to claim 2.
7. The content injection control mechanism is:
   A guide bar movably engaged with the movable holder and the pressing portion;
   An interlocking rod fastened to the movable holder and movably engaged with the pressing portion;
   A connecting rod that extends in the same straight line as the interlocking rod, has a rear end facing the tip of the interlocking rod, can be contacted / separated, and the rear end is located inside the movable holder. The injection device according to claim 2.
8. The interlocking rod and the guide rod have an engaging rack having an inclination on a peripheral surface of a portion that can face the pressing portion,
   The pressing portion includes a pawl that meshes with an engagement rack of the interlocking rod and the guide rod,
   The pressing portion approaches the movable holder and is movable relative to the interlocking rod and the guide rod in a direction to push the pusher into the syringe barrel, and away from the movable holder. The injection device according to claim 7, comprising a ratchet mechanism whose movement is locked.
9. A first elastic member is provided on the movable holder;
   The movable holder has a first through hole through which the guide rod is slidably inserted at a lower portion of a portion holding the syringe barrel, and a slidable insertion at the tip of the connecting rod, and a rear end on the same straight line. A moving support portion formed with a second through hole to which the interlocking rod is fastened,
   When the movable holder moves in the forward direction approaching the contact head, a compressive force is applied to the first elastic member from the guide rod and the connecting rod to the first elastic member,
   The injection apparatus according to claim 7, wherein the movable holder is moved in a direction away from the support mechanism by a restoring force of the first elastic member.
10. A spring holding member protruding from the inner wall is provided on the inner walls of the first through hole and the second through hole,
    The guide rod and the connecting rod are each provided with a small diameter portion and a large diameter portion, and the small diameter portion is located near the center of the movable holder in the extending direction of the guide rod and the connecting rod. Is located on the tip side of the movable holder,
    The front end of the first elastic member is held on a side surface of the guide rod and the connecting rod that is reduced in diameter from a large diameter portion to a small diameter portion, and a rear end is held on the spring holding member. Item 10. The injection device according to Item 9.
11. The side wall on the rear end side of the support mechanism is opened so that a part of the movable holder is inserted, and the tip of the guide rod and the tip of the connecting rod are fixed,
    When the movable holder moves in the forward direction approaching the contact head, the side wall of the support mechanism comes into contact with a part of the movable holder, so that the movable holder moves in the forward direction toward the contact head. Stop moving,
    When the movable holder moves in a retracting direction away from the contact head by the restoring force of the first elastic member, the contents are injected into the subject and the needle tube is moved from the desired depth to the subject surface. The injection device according to claim 10, wherein the needle is retracted until the needle is removed.
12. The support mechanism includes a cover that covers at least the injection needle and a portion of the movable holder that holds the injection needle in the upper and side directions in a circumferential direction, and the movable holder is inserted into the support mechanism. The injection device according to claim 11.
13. The injection device further includes a needle removal control mechanism,
    The contents injection control mechanism moves the needle tube toward the desired position with respect to the subject while the movable holder approaches the pressing portion and pushes the pusher into the syringe barrel. Control the first stage of needle tube retraction, which injects objects into the subject,
    The needle removal control mechanism controls a second-stage needle tube retraction operation in which the needle tube is retracted from a predetermined position to at least the surface of the subject and the needle is withdrawn without injecting the contents into the subject. The injection device according to claim 2.
14. The needle removal control mechanism is
    A control plate comprising an upper surface plate covering at least a part of the upper surface of the support mechanism and a side plate covering a side wall on the rear end side separated from the contact head;
    Two position adjustment pins, each having a large-diameter head and inserted into the side plate of the control plate;
    A second elastic member that is fitted on the outside of the position adjustment pin and is provided in contact with the side plate of the control plate and the support mechanism;
    Two elastic pins provided on the upper surface of the support mechanism, one end of which is held on a part of a side surface of the peripheral surface holding portion of the movable holder, and provided so as to extend in a substantially vertical direction. Has
    The support mechanism includes an upper surface and a side surface, and a guide path for guiding the movement of the movable holder is formed.
    Two grooves are formed on the upper surface of the support mechanism to which the elastic pins are fitted,
    14. An insertion hole serving as an entrance of the guide path into which the position adjustment pin with the second elastic member fitted outside is inserted is formed in the side surface of the support mechanism. The injection device described in 1.
15. The content injection control mechanism is:
    A guide bar movably engaged with the movable holder and the pressing portion;
    An interlocking rod fastened to the movable holder and movably engaged with the pressing portion;
    Extending in the same straight line as the interlocking rod, the rear end is opposed to the tip of the interlocking rod and can be contacted and separated, and the rear end is provided with a connecting rod located inside the movable holder,
    The side wall on the rear end side of the support mechanism is opened so that a part of the movable holder is inserted,
    The side plate of the control plate is opened so that a part of the movable holder is inserted, and the tip of the guide rod and the tip of the connecting rod are fixed,
    When the movable holder moves in the forward direction approaching the contact head, the side plate of the control plate comes into contact with a part of the movable holder, and then the side plate of the control plate By making contact with the side surface, the movement of the movable holder to the contact head in the forward direction is stopped,
    In the first-stage needle tube retraction operation, the movable holder moves in the retraction direction while the movable holder approaches the pressing portion in a state where the side plate of the control plate is in contact with the side surface of the support mechanism. In the second-stage needle tube retraction operation, the side plate of the control plate moves away from the side surface of the support mechanism, and the movable holder moves backward while the movable holder maintains a predetermined distance from the pressing portion. The injection device according to claim 14, wherein the injection device moves in a direction.
16. In the needle removal control mechanism,
    A first elastic member is provided on the movable holder;
    When the movable holder moves a predetermined distance in the proximity direction to the contact head, the first elastic member is provided with the first elastic member provided in the movable holder from the guide rod and the connecting rod. After compressive force is applied to the elastic member,
    When the elastic pin moves in the proximity direction to the contact head together with the movable holder and reaches a predetermined position, the elastic pin is engaged with the groove,
    In a state where the elastic pin is fitted in the groove of the support mechanism, the position adjusting pin and the control plate move toward the contact head, and a compressive force is applied to the second elastic member. The injection device according to claim 15.
17. When the movable holder is no longer applied with a force in the proximity direction to the contact head,
    As a first step, the position of the position adjusting pin and the elastic pin does not change due to the restoring force of the first elastic member, and the movable holder is away from the support mechanism and close to the pressing portion. And injecting the contents into the subject, retracting the needle tube from a desired depth to a predetermined position,
    As a second step, the elastic pin is disengaged, and the position adjusting pin and the control plate are moved so that the movable holder and the guide rod are fitted by the restoring force of the second elastic member. The injection device according to claim 16, wherein the needle tube is retracted from a desired depth to a predetermined position by the movement of the pressing portion.
18. The lower surface of the contact head is configured such that the surface around the opening is positioned inside the other lower surface, and when the content is injected into the subject, the lower surface is in contact with the subject. The injection device according to claim 1, wherein the injection device is in partial contact, and the periphery of the opening is not in contact with the subject.
19. A protrusion protruding in the surface direction of the lower surface is formed continuously or intermittently on the edge of the lower surface of the contact head, and the upper surface of the protrusion is surrounded by the cover so as to surround the opening. The injection device according to claim 18, wherein the injection device is in contact with a specimen.
20. The tip of the needle tube is positioned above a portion of the lower surface of the contact head that comes into contact with the subject before the start of the puncture operation and after the end of the needle extraction operation. Injection device.
21. The opening of the contact head penetrates the lower surface of the contact head in a bifurcated direction in the direction in which the needle tube passes and the vertical direction of the contact head as the movable holder moves.
    The injection device according to claim 1, wherein the opening on the upper surface of the contact head has an elongated hole shape that is elongated from the position corresponding to the injection point toward the support mechanism.
22. The injection device according to claim 1, wherein the support mechanism is provided with a movement guide rail having a circumferential shape that slidably supports at least a part of the movable holder.
23. The lower part of the moving guide rail of the support mechanism is opened so that the needle tube does not contact when the syringe is detached.
    On the lower surface of the contact head, as the opening, an edge of the lower surface of the contact head from a portion penetrating in the vertical direction in the direction in which the needle tube passes along with the movement of the movable holder toward the support mechanism The injection device according to claim 22, wherein a cut shape is provided so as to reach.

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