CN116983137A - Accurate injection device of retina - Google Patents
Accurate injection device of retina Download PDFInfo
- Publication number
- CN116983137A CN116983137A CN202310941695.2A CN202310941695A CN116983137A CN 116983137 A CN116983137 A CN 116983137A CN 202310941695 A CN202310941695 A CN 202310941695A CN 116983137 A CN116983137 A CN 116983137A
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- China
- Prior art keywords
- injection
- inner container
- outer carrier
- head
- injection device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002347 injection Methods 0.000 title claims abstract description 110
- 239000007924 injection Substances 0.000 title claims abstract description 110
- 210000001525 retina Anatomy 0.000 title abstract description 18
- 230000000149 penetrating effect Effects 0.000 claims abstract description 36
- 230000002207 retinal effect Effects 0.000 claims description 15
- 210000003128 head Anatomy 0.000 abstract description 47
- 210000004127 vitreous body Anatomy 0.000 abstract description 6
- 210000005252 bulbus oculi Anatomy 0.000 abstract description 5
- 238000010992 reflux Methods 0.000 abstract description 4
- 208000014674 injury Diseases 0.000 abstract description 2
- 230000008733 trauma Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000007135 Retinal Neovascularization Diseases 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 239000003855 balanced salt solution Substances 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 238000004401 flow injection analysis Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000004256 retinal image Effects 0.000 description 1
- 230000004250 retinal swelling Effects 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a retina accurate injection device, which comprises: the injection device comprises an outer carrier, a penetrating body, an inner container, an injection head and an injection driving part, wherein the penetrating body is arranged at one end of the outer carrier, the inner container is in sliding connection with the outer carrier, the injection head is arranged at one end of the inner container, the injection head is movably arranged at the inner side of the penetrating body, the injection head can stretch out or retract into the penetrating body to be arranged, the injection driving part is arranged at the other end of the inner container, and the injection driving part is used for controlling the output of injection in the inner container. Through the application of the invention, the retina injection device for directly puncturing the vitreous body without cutting the vitreous body is provided, and the injector head is protected through the cooperation of the puncture body and the external carrier, so that the injector head can be directly released at an injection point of the retina to work, the injection dosage is easy to control, the injection dosage is ensured to be effective, the occurrence of reflux problem is avoided, the trauma to eyeballs of a patient is reduced, and the operation difficulty is lower.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a retina accurate injection device.
Background
Subretinal injection is an emerging accurate injection treatment method, and the injection part generally relates to retina and blood vessels thereof, and is commonly used for gene therapy, cell therapy, tissue type plasminogen activator injection retinal blood vessel obstruction, anti-VEGF therapy of retinal neovascularization and the like of retinal degenerative diseases.
In the prior art, subretinal injection generally requires very delicate procedures to avoid damage to the retina and blood vessels and the risk of drug reflux. At present, a two-step method is more common in clinic for subretinal injection, namely, a method of injecting medicines by prefabricating balanced salt solution blisters after performing three-incision vitrectomy on the pars plana.
However, this method of cutting before injection often has a large intraocular damage to the patient and a high difficulty in repeated administration. And the two-step subretinal injection is difficult to control the injection dosage, the treatment requirement is difficult to be met due to the fact that the medicine is injected too little, and the medicine reflux is caused due to the fact that the medicine is injected too much, and even the risk of rupture of retina or macula is increased. The two-step subretinal injection is complex and tedious in operation, long in operation time and relatively high in operation risk, so that the technical requirements on operation operators are high.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a retina precision injection device, comprising: the injection device comprises an outer carrier, a penetrating body, an inner container, an injection head and an injection driving part, wherein the penetrating body is arranged at one end of the outer carrier, the inner container is in sliding connection with the outer carrier, the injection head is arranged at one end of the inner container, the injection head is movably arranged at the inner side of the penetrating body, the injection head is movably stretched out or contracted into the penetrating body, the injection driving part is arranged at the other end of the inner container, and the injection driving part is used for controlling the output of injection in the inner container.
In another preferred embodiment, further comprising: the limiting assembly is arranged on the outer carrier and used for limiting the sliding of the inner container.
In another preferred embodiment, the spacing assembly comprises: the first part is arranged at one end of the outer carrier, and the second part is arranged at the other end of the outer carrier.
In another preferred embodiment, further comprising: the first clamping piece and the second clamping piece are sequentially arranged on the outer wall of the inner container along the length direction of the inner container, the first clamping piece is movably propped against the first part, and the second clamping piece is movably propped against the second part.
In another preferred embodiment, further comprising: the positioning assembly is arranged on the outer carrier and used for locking or releasing the first clamping piece.
In another preferred embodiment, the positioning assembly comprises: the first clamping head is arranged on the outer carrier, a limiting distance is reserved between the first clamping head and the first part, a clamping groove is formed in the first clamping piece, and one end of the first clamping head is matched with the clamping groove.
In another preferred embodiment, the positioning assembly further comprises: the second clamping head is arranged on the outer carrier, the second clamping head is arranged close to the penetrating body relative to the first clamping head, and one end of the second clamping head is matched with the clamping groove.
In another preferred embodiment, the outer carrier is arranged in a cylindrical configuration and the inner container is arranged inside the outer carrier.
In a further preferred embodiment, the penetrating body and the injection head are each arranged in a needle-shaped configuration.
In another preferred embodiment, further comprising: and an elastic body for applying an elastic force to the inner container toward the vicinity of the penetrating body.
By adopting the technical scheme, the invention has the positive effects compared with the prior art that: through the application of the invention, the retina injection device for directly puncturing the vitreous body without cutting the vitreous body is provided, and the injector head is protected through the cooperation of the puncture body and the external carrier, so that the injector head can be directly released at an injection point of the retina to work, the injection dosage is easy to control, the injection dosage is ensured to be effective, the occurrence of reflux problem is avoided, the trauma to eyeballs of a patient is reduced, and the operation difficulty is lower.
Drawings
FIG. 1 is a schematic view showing the retraction of an injector head of a retinal precision injection device according to the present invention;
fig. 2 is a schematic view showing the extension of an injection head of a retinal precise injection device according to the present invention.
In the accompanying drawings:
1. an outer carrier; 2. a penetrating body; 3. an inner container; 4. an injection head; 5. an injection driving part; 6. a limit component; 7. a first portion; 8. a second portion; 9. a first clamping piece; 10. a second clamping piece; 11. a positioning assembly; 12. a first chuck; 13. and a second chuck.
Detailed Description
The invention is further described below with reference to the drawings and specific examples, which are not intended to be limiting.
As shown in fig. 1 and 2, there is shown a retinal precision injection device of a preferred embodiment, comprising: the injection device comprises an outer carrier 1, a penetrating body 2, an inner container 3, an injection head 4 and an injection driving part 5, wherein the penetrating body 2 is arranged at one end of the outer carrier 1, the inner container 3 is in sliding connection with the outer carrier 1, the injection head 4 is arranged at one end of the inner container 3, the injection head 4 is movably arranged at the inner side of the penetrating body 2, the injection head 4 is movably extended or retracted into the penetrating body 2, the injection driving part 5 is arranged at the other end of the inner container 3, and the injection driving part 5 is used for controlling output of injection liquid in the inner container 3. Further, when the injection head 4 is in the retracted state, the operator can hold the hand or insert the penetrating body 2 into the vitreous body of the patient by the auxiliary robot, then drive the inner container 3 to move in a direction approaching the eyeball so that the injection head 4 protrudes out of the penetrating body 2, and then drive the injection liquid to be injected into the eyeball by the injection driving part 5. In the specific use process: first, anesthetizing the eyeball or the whole body of a patient; then, the injection head 4 can be first extended out of the penetrating body 2 to extract the drug injection based on the injection driving part 5 or the drug is directly injected from the rear end direction of the inner container 3 through the injection driving part 5, and the injection head 4 is retracted into the penetrating body 2 after the preparation of the injection is completed; the operator can insert the penetrating body 2 into the vitreous body of the patient based on the cannula left at the scleral incision created by the minimally invasive vitrectomy or directly, and then acquire clear posterior segment retinal images and locate the injection point by optical coherence tomography through the surgical microscope; after the penetration direction is aligned, the inner container 3 is driven in a sliding way, so that the injection head 4 contacts with the surface of the retina in a moving direction inclined by 45 degrees, the injection head 4 slightly pierces the retina, the tip of the injection head 4 is in low reflection, the retina is in small concave shape when being pressed by the tip of the injection head 4, and the surgical microscope confirms that the tip is positioned in the subretinal space; then, the injection driving part 5 is controlled to enable the medicine injection to be injected under the retina, the image of the operation microscope can enable the medicine to enter the subretinal cavity, the height of the retinal swelling is gradually increased, and the swelling range is gradually enlarged; the height of the fovea retinal bulge and the thickness of the retina are monitored in real time, and after the medicine dosage is set, the whole injection device is withdrawn from the original path; if the concave profile is reversed or overstretched in the process, the injection is stopped immediately, and the original path is withdrawn.
Further, as a preferred embodiment, the relative movement between the inner container 3 and the outer carrier 1 may be driven manually or assisted by other means.
Further, as a preferred embodiment, the method further comprises: the limiting component 6, limiting component 6 sets up on outer carrier 1, and limiting component 6 is used for restricting the slip of inner container 3. Further, the limiting assembly 6 serves to limit the sliding space of the inner container 3, especially at the front and rear ends in the direction of movement of the injection head 4.
Further, as a preferred embodiment, the limiting assembly 6 includes: a first part 7 and a second part 8, the first part 7 being arranged at one end of the outer carrier 1 and the second part 8 being arranged at the other end of the outer carrier 1. Further, the inner container 3 is placed in a forward movement too much by the arrangement of the first portion 7 and the arrangement of the second portion 8 prevents the inner container 3 from being pulled out of the outer carrier 1.
Further, as a preferred embodiment, the method further comprises: the first clamping piece 9 and the second clamping piece 10 are sequentially arranged on the outer wall of the inner container 3 along the length direction of the inner container 3, the first clamping piece 9 is movably propped against the first part 7, and the second clamping piece 10 is movably propped against the second part 8.
Further, as a preferred embodiment, the first clamping member 9 and the second clamping member 10 are each arranged in a flat annular structure.
Further, as a preferred embodiment, the radially inner contour of the outer carrier 1 is arranged in a circle.
Further, as a preferred embodiment, the radially outer contours of the first and second clips 9, 10 match the radially inner contour of the outer carrier 1 to provide guidance for sliding of the inner container 3.
Further, as a preferred embodiment, the first portion 7 and the second portion 8 are provided in a sleeve structure, the first portion 7 and the second portion 8 being fixedly provided on the side of the outer carrier 1 close to the inner container 3.
Further, as a preferred embodiment, the method further comprises: the positioning component 11, the positioning component 11 is arranged on the outer carrier 1, and the positioning component 11 is used for locking or releasing the first clamping piece 9.
Further, as a preferred embodiment, the positioning assembly 11 includes: the first clamping head 12, the first clamping head 12 is arranged on the outer carrier 1, a limiting distance is arranged between the first clamping head 12 and the first part 7, a clamping groove is formed in the first clamping piece 9, and one end of the first clamping head 12 is matched with the clamping groove.
Further, as a preferred embodiment, the positioning assembly 11 further comprises: the second clamping head 13, the second clamping head 13 sets up on outer carrier 1, and second clamping head 13 is close to penetrating body 2 relative to first clamping head 12 and sets up, and the one end and the draw-in groove phase-match of second clamping head 13.
Further, as a preferred embodiment, the first chuck 12 and the second chuck 13 are movably disposed on the outer carrier 1, and the other end of the first chuck 12 and the other end of the second chuck 13 are disposed outside the outer carrier 1. Further, the operator can form a lock and release of the inner container 3 by operating the respective cartridge on the outside of the outer carrier 1 to enable the cartridge to be inserted into or removed from the card slot.
Further, as a preferred embodiment, the outer carrier 1 is provided with limiting holes for movement of the first chuck 12 and the second chuck 13.
Further, as a preferred embodiment, the first chuck 12 and the second chuck 13 are spaced apart by 5mm.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the embodiments and the protection scope of the present invention.
The present invention has the following embodiments based on the above description:
in a further embodiment of the invention, the outer carrier 1 is arranged in a cylindrical configuration and the inner container 3 is arranged inside the outer carrier 1.
In a further embodiment of the invention, the other end of the inner container 3 protrudes from the other end of the outer carrier 1.
Further, as a preferred embodiment, the outer side of the other end of the inner container 3 extends radially outwardly to form a first urging portion, and the outer side of the other end of the outer carrier 1 extends radially outwardly to form a second urging portion. Further, the operator can hold the outer carrier 1 by means of a similar hand-held conventional needle syringe and drive the movement of the inner container 3 accordingly, as well as the movement of the injection drive 5.
In a further embodiment of the invention, both the penetrating body 2 and the injection head 4 are arranged in a needle-shaped configuration.
In a further embodiment of the invention, the inner diameter of the penetrating body 2 is greater than or equal to the outer diameter of the injection head 4.
In a further embodiment of the present invention, further comprising: further comprises: and an elastic body for applying an elastic force to the inner container 3 toward the vicinity of the penetrating body 2.
In a further embodiment of the invention, one end of the elastomer is against or connected to the inner wall of the outer carrier 1 or to the end face of the second part 8 adjacent to the first part 7, and the other end of the elastomer is against or connected to the outer wall of the inner container 3 or to the end face of the first clip member 9 or to the end face of the second clip member 10. Further, the elastomer is used to provide a tendency for the inner container 3 to move towards the penetrating body 2; specifically, in the initial retracted state of the injector head 4, the first chuck 12 locks the inner container 3, and the elastic body is in a compressed state, and when the first chuck 12 is moved outwards to disengage from the chuck groove, the elastic body rapidly expands and drives the inner container 3 to rapidly move, so that the injector head 4 performs an ejecting action relative to the penetrating body 2 to rapidly penetrate the retina injection point of the patient.
In a further embodiment of the invention the elastic body is preferably a spring, which is sleeved outside the inner container 3.
In a further embodiment of the invention, the injection driving part 5 is a piston rod or a micro-flow injection device.
In a further embodiment of the present invention, when the injection driving part 5 is a piston push rod, one end of the piston push rod extends into the inner container 3 to drive the inner container 3 to inject and suck the corresponding injection liquid along with the push and pull of the piston push rod.
In a further embodiment of the invention, when the injection driving part 5 is a micro-flow syringe, the output end of the micro-flow syringe is directly extended into the inner container 3 through a pipeline, preferably close to the injection head 4 and forms a seal with the inner wall of the inner container 3.
In a further embodiment of the invention, both the outer carrier 1 and the inner container 3 are made of polypropylene material.
In a further embodiment of the invention, the outer carrier 1 and the inner container 3 are both arranged in a transparent manner, and when the injection driving part 5 is a piston push rod, graduation marks are arranged on the inner container 3. Further, the operator can directly observe the scale value on the inner container 3 through the outer carrier 1.
In a further embodiment of the invention, the minimum tick mark is 0.01ml.
In a further embodiment of the invention the volume of the inner container 3 is 1ml.
In a further embodiment of the invention, the length of the injection head 4 is about 50mm.
In a further embodiment of the invention, the length of the penetrating body 2 is about 40mm.
In a further embodiment of the invention, the tip of the injection head 4 exceeds the tip of the penetrating body 2 by about 5mm when the injection head 4 is in the extended state.
In a further embodiment of the invention, the penetrating body 2 and the injection head 4 are both made of stainless steel material.
The foregoing description is only illustrative of the preferred embodiments of the present invention and is not to be construed as limiting the scope of the invention, and it will be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and illustrations of the present invention, and are intended to be included within the scope of the present invention.
Claims (10)
1. A retinal precision injection device, comprising: the injection device comprises an outer carrier, a penetrating body, an inner container, an injection head and an injection driving part, wherein the penetrating body is arranged at one end of the outer carrier, the inner container is in sliding connection with the outer carrier, the injection head is arranged at one end of the inner container, the injection head is movably arranged at the inner side of the penetrating body, the injection head is movably stretched out or contracted into the penetrating body, the injection driving part is arranged at the other end of the inner container, and the injection driving part is used for controlling the output of injection in the inner container.
2. The retinal precision injection device of claim 1, further comprising: the limiting assembly is arranged on the outer carrier and used for limiting the sliding of the inner container.
3. The retinal precision injection device of claim 2, wherein the stop assembly comprises: the first part is arranged at one end of the outer carrier, and the second part is arranged at the other end of the outer carrier.
4. The retinal precision injection device of claim 3, further comprising: the first clamping piece and the second clamping piece are sequentially arranged on the outer wall of the inner container along the length direction of the inner container, the first clamping piece is movably propped against the first part, and the second clamping piece is movably propped against the second part.
5. The retinal precision injection device of claim 4, further comprising: the positioning assembly is arranged on the outer carrier and used for locking or releasing the first clamping piece.
6. The retinal precision injection device of claim 5, wherein the positioning assembly comprises: the first clamping head is arranged on the outer carrier, a limiting distance is reserved between the first clamping head and the first part, a clamping groove is formed in the first clamping piece, and one end of the first clamping head is matched with the clamping groove.
7. The retinal precision injection device of claim 6, wherein the positioning assembly further comprises: the second clamping head is arranged on the outer carrier, the second clamping head is arranged close to the penetrating body relative to the first clamping head, and one end of the second clamping head is matched with the clamping groove.
8. The retinal precision injection device according to claim 1, wherein the outer carrier is provided in a cylindrical structure, and the inner container is provided inside the outer carrier.
9. The retinal precision injection device according to claim 9, wherein the other end of the inner container is provided protruding from the other end of the outer carrier.
10. The retinal precision injection device according to claim 5 or 6, further comprising: and an elastic body for applying an elastic force to the inner container toward the vicinity of the penetrating body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310941695.2A CN116983137A (en) | 2023-07-28 | 2023-07-28 | Accurate injection device of retina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310941695.2A CN116983137A (en) | 2023-07-28 | 2023-07-28 | Accurate injection device of retina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116983137A true CN116983137A (en) | 2023-11-03 |
Family
ID=88531498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310941695.2A Pending CN116983137A (en) | 2023-07-28 | 2023-07-28 | Accurate injection device of retina |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116983137A (en) |
-
2023
- 2023-07-28 CN CN202310941695.2A patent/CN116983137A/en active Pending
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