KR20200002578A - Injection device - Google Patents

Abstract

The injection device 1 which inject | pours the content to the said subject by the syringe provided with the injection needle which consists of a piston, the syringe into which the said piston is inserted, the needle base connected to the said syringe, and the needle tube put into the subject, An abutting head (10) having an opening through which a needle tube passes, a movable holder (30) holding a syringe and a needle, a support mechanism (20) fixed to the abutting head; And a content injection control mechanism 50 for pushing the piston into the syringe barrel. The movable holder moves along the support mechanism to move the syringe and the needle against the abutting head. The syringe is removable for the injection device.

Description

Injection device

The present invention relates to an injection device, and more particularly, to a device suitable for injection, supply or administration of various substances into a tissue, including cells.

In cell therapy or the like, it is sometimes desirable to inject a predetermined substance such as cells into the treatment site in the skin precisely in a predetermined amount and at a predetermined depth.

In addition, when a small amount of cells or the like is injected into a single layer or a single region, it is necessary to divide a predetermined amount into a plurality of circuits and to inject dispersedly in a plurality of different directions.

In addition, when the predetermined amount of contents are divided into a plurality of circuits and dispersedly injected in a plurality of different directions, it is preferable that the influence on the subject is divided equally. It is sometimes desirable to.

In order to solve such a problem, Patent Document 1 has been proposed in which an injection needle housing for fixing an injection needle is installed in the injection device, the injection needle is fixed therein, and the syringe can be detachably attached to the fixed injection needle. have. In such an injection device, an injection operation is performed at a predetermined speed by an internal drive system and a retraction system.

Japanese Patent Publication No. 2015-505487

However, in the technique of Patent Literature 1, since the needles are fixed inside, when a plurality of patients or subjects are injected using such a device, the risk of pain due to infections such as infectious diseases, infectious diseases, wear of the needles, etc. Since it is high, it is necessary to make injection device itself disposable.

In addition, in a structure in which the injection device of interest and the injection needle for a syringe cannot be detached from each other, the device may be handled as a higher medical device, and there is a fear that the report, return, etc. of the device become strict.

In addition, when a substance having a highly viscous gel-like structure is used as the content to be injected by injection, the syringe may be detached from the fixed injection needle due to high pressure during use.

Accordingly, an object of the present invention is to provide an injection apparatus capable of preventing the injection needle from escaping from the syringe at the time of use, and detaching the syringe.

According to one aspect of the present invention, the contents are injected into the subject by a syringe comprising a piston, a syringe into which the piston is fitted, a needle support connected to the syringe and a needle tube inserted into the subject. An injection apparatus for contacting the test object includes a contact head having an opening through which the needle tube passes, a movable holder holding the syringe barrel and the injection needle, and a support mechanism fixed to the contact head. And a content injection control mechanism for pushing the piston into the syringe, wherein the movable holder moves along the support mechanism to move the syringe and the injection needle relative to the abutting head, and the syringe Is removable to the said injection apparatus, It is characterized by the above-mentioned.

According to one aspect of the present invention, the injection device can prevent detachment of the injection needle from the syringe at the time of use, and can detach the syringe.

1A and 1B are explanatory diagrams of the injection apparatus of the first embodiment of the present invention.
2A and 2B are schematic diagrams of a syringe applied to the injection device of the present invention.
3A and 3B are explanatory views of the movable holder in the scanning device of FIGS. 1A and 1B.
4A to 4D are explanatory views of the movable holder and the support mechanism in the scanning device of FIGS. 1A and 1B.
5A and 5B are explanatory views of the movable mechanism and the rod-shaped member on the lower surface of the movable holder shown in Figs. 4A to 4D.
It is explanatory drawing of the ratchet mechanism in a press part in the injection apparatus of FIG. 1A and 1B.
7A to 7C are explanatory diagrams of abutting heads in the scanning device of FIGS. 1A and 1B.
8 is an explanatory view of the operation of the injection device according to the first embodiment of the present invention.
9 is an explanatory diagram of a scanning operation flow according to the first embodiment.
10A and 10B show an injection device according to a second embodiment of the present invention.
11A and 11B are enlarged views of the needle control mechanism of the injection apparatus of FIGS. 10A and 10B.
12 is a perspective perspective view of the injection device of FIGS. 10A and 10B.
It is explanatory drawing of the operation of the injection apparatus which concerns on 1st Embodiment of this invention.
It is explanatory drawing of the scanning operation flow which concerns on 2nd Embodiment.
15A to 15C are explanatory diagrams in the case of marking a subject under the use of an injection template.
16A to 16G are explanatory diagrams for assembling a syringe.
17A and 17B are diagrams in the case where the injection device is equipped with a syringe and the injection device is brought into contact with the subject, respectively.

1A and 1B are explanatory diagrams of the injection apparatus of the first embodiment of the present invention. 1A is a perspective view, and FIG. 1B is a side view.

[Full description]

The injection device 1 is an injection device which is equipped with a syringe for injecting contents containing a substance such as a cell suspension into a subject (human, animal, individual organ, skin, etc.). The injection device 1 functions as an injection syringe holder (injector holder) for injecting an appropriate amount of contents into a subject using a syringe.

The injection apparatus is provided with the contact head 10, the support mechanism 20, the movable holder 30, and the content injection control mechanism 50.

The abutting head 10 can abut the object under test, and an opening is formed. The abutting head 10 is located at the tip of the injection device 1. When the needle insertion / needle extraction operation is performed on the subject, the needle tube 83 described later passes through the opening 11 (see FIG. 4B).

The support mechanism 20 is fixed to the contact head 10 at a predetermined angle. The scanning angle with respect to a subject is set by the engagement angle of the support mechanism 20 and the contact head 10. FIG. The contact head 10 and the support mechanism 20 may be integrally manufactured, or may be separately manufactured and then fixed by welding or the like.

The support mechanism 20 is a holder receiving part which defines the stop position of the movable holder 30 movement, receives the movable holder 30, and makes it stop.

The movable holder 30 holds the syringe 84 and the injection needle 81 (see FIG. 2A) and is movable along the support mechanism 20 with respect to the abutting head 10. The movable holder 30 moves with respect to the abutting head 10, so that the subject can contact the abutting head 10 with the syringe 84 and the injection needle 81 held by the movable holder 30. Move it. By this relative movement, it moves with respect to a test subject in the forward direction which is a direction which puts the needle tube 83 of the syringe 80, and a retraction direction which is a pulling direction.

The contents injection control mechanism 50 pushes the piston 88 toward the syringe barrel 84. The contents injection control mechanism includes a pressing portion 40, a guide rod 51, an interlocking rod 52, a connecting rod 53, and elastic members 54 and 55 (see FIGS. 5A and 5B).

Here, in the injection apparatus 1 of this invention, a syringe and an injection needle are removable as a syringe. 2A and 2B are explanatory views of the syringe, FIG. 2A shows a post-assembly syringe, and FIG. 2B shows an exploded view of the syringe.

As shown to FIG. 2A and FIG. 2B, the syringe 80 is comprised from the injection needle 81, the syringe barrel 84, and the piston 88. As shown in FIG. Syringe 84 (cylinder) holds the contents and piston 88 is fitted. In detail, the scanning cylinder 84 is provided with the outer cylinder part 85 which accommodates a content, the flange 86 provided in the rear end of the outer cylinder part 85, and the cylinder front end 87. As shown in FIG.

Here, in the injection device of the present invention, a syringe having a volume of 1 mL is suitable as necessary when used. This 1 mL syringe allows 10 100 μL injections and 6 166 μL injections. Syringes with 2, 5, or 10 mL may also be used. Depending on the specific use of the injection device, the syringe may have a larger or smaller volume.

The injection needle 81 is connected to the syringe barrel 84. In detail, the injection needle 81 is provided with the needle base 82 fitted in the outer cylinder tip 87 of the injection cylinder 84, and the needle tube 83 put into a subject. When setting the syringe 80, the cylinder tip 87 of the syringe barrel 84 is inserted into the needle support 82 of the injection needle 81 to engage. It is also possible to use a syringe having a structure that locks the needle holder 82 of the injection needle 81 and the cylinder tip 87 of the injection barrel 84 so that they are not easily separated.

Here, if the diameter of the needle tube of the injection needle applied to the injection apparatus of this invention exists in the range of 18-34G and 20-30G, it is suitable suitably. More preferably, it is 26G, 27G, or 30G.

The piston 88 (plunger) moves in the outer cylinder portion 85 of the syringe 87 by pressurizing the head (rear portion, 88h), whereby the contents are released from the syringe. A gasket 89, which is a thin rubber packing (sealing element), is adhered to the tip of the piston 88 to prevent liquid leakage, to prevent foreign matter from being mixed.

Here, in the present invention, since the syringe barrel 84 and the injection needle 81 shown in FIG. 2A are integrated and can be attached and detached together, the contents contained in the syringe barrel 84 are placed inside the injection apparatus 1. The injection device 1 can be reused without being attached or with as few attachments as possible. Here, the syringe barrel 84 and the injection needle 81 should just be integrated by connection at the time of attaching and detaching at least to the injection apparatus 1, and when it is mounted in the injection apparatus 1, When outside, the syringe barrel 84 and the injection needle 81 may each be in a separate state.

[Movable holder (syringe holder)]

3A and 3B show enlarged cross-sectional views of the upper surface of the movable holder 300. 3A is a perspective view, and FIG. 3B is a cross-sectional top view taken along the line A-A 'in FIG. 3A.

The movable holder 30 includes a syringe holder composed of a front holder 310 and a rear holder 320 positioned at an upper portion thereof, and two through holes 331, 332 through which the rod-shaped members 51, 52, and 53 pass. 5) is provided with the movable support part 330. In addition, coil springs 54 and 55 serving as the first elastic members are provided inside the moving support part 330.

The 310,320 in the upper part of the movable holder () has a flange fitting part 31, the outer cylinder part clamping part 32, the needle base stopper 33, and the circumferential surface holding part 34. As shown in FIG.

The flange fitting portion 31 is fitted to the flange 86 of the syringe barrel 84. As shown in FIG. 3B, the flange fitting portion 31 has a wing-like outer frame shape when viewed from the top, and is engaged by fitting the flange 86 into the outer frame shape. By this engagement, the position of the flange 86 is determined and it restricts the movement of the flange 86 to the movable holder 30 in the separation direction (retraction direction, arrow B direction of FIG. 1B).

The outer cylinder clamping portion 32 sandwiches and holds the position of the outer cylinder portion 85 of the scanning cylinder 84 on both sides. The outer cylinder part clamping part 32 is a linear protrusion shape standing up to a lip shape so that it may follow both sides of the cylindrical outer cylinder part 85 side surface. By this structure, the outer cylinder portion clamping portion 32 restricts the lateral displacement of the outer cylinder portion 85, that is, the lateral shift in the movable holder 30. Even if the movable holder 30 moves, the holding state can be stably maintained.

The needle base stopper 33 regulates the movement of the needle base 82 of the injection needle 81. In the example of the syringe shown to FIG. 2A and FIG. 2B, the tip of the needle base 82 is predetermined surface shape, and the needle base stopper 33 shown to FIG. 3A and FIG. 3B has a needle base as the inner diameter is reduced in diameter. The end face of (82) can be abutted.

In Fig. 3A, the needle support stopper 33 extends vertically in the direction of stopping with respect to the movement direction of the syringe 80, and passes through the needle tube 83, but is at the tip of the needle support 82 (in the movement direction). Vertical surface), which is in contact with the needle support stopper 33, restricts the movement of the syringe 80 with respect to the movable holder 30. On the other hand, the needle support stopper 33 may not be perpendicular to the direction in which it stops with respect to the moving direction of the syringe 80, for example, the needle support 82 may be stopped by gradually reducing the shape of the circumference. In addition, when the vertical surface of the tip of the needle base 82 does not exist, and the diameter of the needle base 82 gradually increases toward the portion where the shape of the needle base 82 is connected to the syringe barrel 84, the needle base stopper ( 33 may abut the side of needle rest 82 to restrict movement of syringe 80 relative to movable holder 30.

With this configuration, the direction in which the needle base 82 approaches the opening 11 in the movable holder 30 toward the opening 11 when the syringe 80 is mounted with the injection device 1 and in the middle of the injection operation (forward direction) , Arrow A direction in FIG. 1B).

The peripheral surface holding portion (needle base peripheral surface holding portion 34) holds the peripheral surface of the needle base 82 of the injection needle 81 in the peripheral surface shape. On the other hand, the circumferential surface holding portion 34 may also hold the tip of the outer cylinder portion 82 of the scanning cylinder 81 in the circumferential surface shape. The peripheral surface holding part 34 shown to FIG. 3A and FIG. 3B has the cylindrical shape which covers the whole peripheral surface along the peripheral surface direction of the tip of the needle base 84 and the outer cylinder part 85. As shown in FIG. On the other hand, the circumferential surface holding portion 34 may not cover the entire circumference, for example, may be a shape that follows the semicircular shape to the shape of the tip of the needle base 82 and the outer cylinder portion 85. By this circumferential surface holding part 34, the lateral displacement of the needle base 82 and the outer cylinder part with respect to the movable holder 30 is regulated. By this structure, when the movable holder 30 moves, it can prevent the shift (deviation) to move to the horizontal direction (short direction) of a holding state.

As described above, in the movable holder 30, the flange fitting portion 31 is regulated to move in the separation direction of the syringe barrel 84 (retraction direction indicated by arrow B in Fig. 1B), and the needle support stopper 33 ) Is controlled to move in the proximal direction of the injection needle 81 (the forward direction indicated by the arrow A in Fig. 1B), so that the combined state of the injection cylinder 84 and the injection needle 81 is maintained in the movement direction.

Thus, even if the syringe 84 and the injection needle 81 move together with the movable holder 30, the injection needle 81 will be detached from the syringe 84 to prevent the contents from leaking into the injection device 1. Can be.

On the other hand, the outer cylinder portion clamping portion 32 of the movable holder 30 may not stand in the entire section along the outer cylinder portion 85 of the syringe 80. As shown to FIG. 3A, a part of protrusion of the outer cylinder part clamping part 32 is cut | disconnected. By providing the flat part 35, it becomes easy to fit the syringe 80 into the movable holder 30, and the operability at the time of attaching and detaching the syringe 80 is improved.

[Support mechanism]

The support mechanism 20 is demonstrated using FIGS. 4A-4D and FIG. 1B. 4A shows a perspective view of the abutting head 10 and the support mechanism 20, and FIG. 4B shows a perspective view seen from another direction. 4C shows an arrow view from the injection direction of the abutting head 10 and the support mechanism 20. The abutting head 10 and the support mechanism 20 function as a stationary fixing member (main body) with respect to the movable holder 30 which is movable.

The support mechanism 20 is fixed with respect to the abutting head 10. The contact angle of the needle tube 83 of the syringe 80 with respect to the subject under test is set by the connection angle between the contact head 10 and the support mechanism 20.

Preferably the angle between the support mechanism 20 and the contact head 10 which sets a scanning angle may be 10-90 degrees, More preferably, it is in the range of 15-25 degrees.

The support mechanism 20 has a top cover 24 and a side wall 23, and a cylindrical holder guide path (insertion through hole, 21) for guiding the movement of the movable holder 30 inside the support mechanism 20. ) Is formed. Here, the opening part 230 which is an inlet of the insertion hole of the holder guide path 21 into which the movable holder 30 is inserted is formed in the side wall 23 located in the rear end of the support mechanism 20.

Located below the holder guide path 21 which allows the movable holder 30 to move along the support mechanism 20 functions as a movement guide rail 22 which guides the movement of the movable holder 30.

Below the support mechanism 20, the incision part (opening part 25) extended in the horizontal direction (injection direction) is formed. By opening the lower part, the tip of the needle tube 83 is prevented from contacting the inside of the injection device 1 when the syringe 80 is attached or detached.

In this embodiment, as the movement guide rail 22, the holder guide path 21, which is a cylindrical insertion through hole for inserting the tip (at least the portion holding the injection needle 81) of the movable holder 30, Portions other than the lower surface of the inner circumferential surface have a shape along the shape of the tip of the movable holder 30 (circumferential surface holding portion 34).

As shown to FIG. 4A and FIG. 4C, in the support mechanism 20, the upper side and both sides of the holder guide path 21 are covered by semi-circle shape. In detail, the support mechanism 20 is a part holding the injection needle 81 and the injection needle 81 of the movable holder 30 at least from above and a side (needle support stopper 33, the peripheral surface holding part ( 34) is provided with an upper cover 24 covering the circumferential surface direction. Therefore, in this embodiment, the support mechanism 20 is a housing shape in which the lower part is opened and the holder guide path 21 which is a cylindrical insertion hole extended in the movement direction for guiding the movable holder 30 is formed. It is.

In the present embodiment, the side wall 23 of the support mechanism 20 stops moving (moving forward) in the direction in which the movable holder 30 approaches the contact head 10. That is, the end point of the slide movement is defined. The tip of the guide rod 51 and the tip of the connecting rod 53 are fixed (connected) to the side wall 23 of the support mechanism 20. In detail, the side wall 23 is provided with the side wall fixing part 23G which fixes the guide rod 51, and the side wall fixing part 23J which fixes the connecting rod 53 (FIGS. 5A and 5B). Reference). As shown in FIGS. 5A and 5B, the side wall fixing portions 23G and 23J may include a guide rod 51, a fastening member for fastening the connecting rod 53, an adhesive member for bonding, and the like.

On the other hand, the cylindrical housing which forms a holder guide path | route may be opened upward (the top cover 24 may not be provided). For example, in the present embodiment, the support mechanism 20 moves and guides at least a part of the movable holder 30 (the part holding the needle base) to the contact head 10. It is sufficient that there is a movement guide rail 22 and a side wall 23 serving as a stopper defining the movement end.

However, as shown in FIG. 4A and FIG. 4C, by providing the top cover 24 in this embodiment, it becomes possible to guide the front end of the movable holder 30 in the circumferential surface, and it is effective to stabilize a movement more. . And / or the safety and hygiene aspects of the operator can be considered.

[Contents injection control mechanism]

FIG. 5A is an exploded view showing the contents injection control mechanism 50 of the present invention, and FIG. 5B is a sectional view showing the moving support portion 330 on the lower surface of the contents injection control mechanism 50 and the movable holder 30. 5B is corresponded to sectional drawing of the B-B 'surface of FIG. 1A.

The injection apparatus 1 of embodiment of this invention is a content injection control mechanism 50, Comprising: The press part 40, the guide rod 51, the interlocking rod 52, the connecting rod 53, and the coil spring (1st) Elastic members 54 and 55 are provided.

The pressurizing portion 40 pressurizes the piston 88 into the syringe barrel 84 in which the movable holder 30 is held.

The guide rod 51, the interlocking rod 52, and the connecting rod 53 are rod-shaped members that control the relative movement of the movable holder 30. The guide rod 51 is coupled to the movable holder 30 and the pressing portion 40 so as to be relatively movable.

Interlocking rod 52 is fastened to the movable holder 30, it is coupled to the pressing portion 40 to be movable. The connecting rod 53 extends on the same straight line as the interlocking rod 52, and an end portion (rear end) is able to contact / separate opposite the end portion (front end) of the interlocking rod 52. In addition, the tip of the connecting rod 53 is located inside the movable holder 30.

5B, the 1st elastic members (coil spring: 54, 55) are provided in the inside of the movable holder 30. As shown in FIG.

The lower part of the movable holder 30 shown in FIG. 5B shows the movable support part 330 provided in the lower part of the part which holds the syringe barrel 84. As shown in FIG.

The first support hole 331 through which the guide rod 51 is slidably inserted, and the connecting rod 53 are slidably inserted into the movable support part 330, and the interlocking rod 52 is provided at the rear end of the same straight line. ) Is formed with a second through hole 332.

The guide rod 51 and the connecting rod 53 are movable with respect to the through holes 331 and 332 of the movable holder 30, respectively.

In addition, the interlocking rod 52 is fixed by the adhesive member 38 at the predetermined position of the through hole 332 of the movable holder 30.

When the movable holder 30 moves in the proximal direction toward the abutting head 10, the coil spring provided inside the movable holder 30 from the guide rod 51 and the connecting rod 53 with respect to the first elastic member is formed. 1 An elastic force is applied to the elastic members 54 and 55.

The pressing portion 40 is coupled to the guide rod 51 and the interlocking rod 52. The press part 40 is a piston press part which abuts the head part (rear end part 88h) of the piston 88, and pushes the piston 88 by relative movement. By the restoring force of the coil springs 54 and 55 provided in the movable holder 30, the distance between the movable holder 30 and the contact head 10 and the distance between the movable holder 30 and the pressing part 40 change. do. Details of the distance change will be described later with reference to FIGS. 8 and 9.

Here, when the distance to which the movable holder 30 is moved is constant, the compressive force applied to the coil springs 54 and 55 becomes constant. Therefore, when a predetermined amount of contents is divided into a plurality of circuits and the injection amount of each is the same, the moving amount of the movable holder 30 becomes constant, so that the compressive force and the subsequent restoring force of the coil springs 54 and 55 become constant. The injection operation can be performed at the injection speed.

On the inner wall of the through holes 331 and 332 for passing the rod-shaped members 51, 52 and 53 provided in the lower part of the movable holder 30, the projections 36 and 37 (that is, the through holes 331 and 332 have small diameters). Part) is provided as a spring holding member.

The guide rod 51 and the connecting rod 53 are provided with the small diameter part and the large diameter part, respectively. The small diameter portions 51S and 53S are positioned near the center of the movable holder 30 in the extending direction of the guide rod 51 and the connecting rod 53, and the large diameter portions 51F and 53F are supported by the movable holder 30. It is located in the mechanism 20 side (front end side).

The coil springs 54 and 55 are fitted outside the small diameter portions 51S and 53S of the guide rods 51 and 53. The guide rod 51 in which the coil spring 54 is fitted outside is fitted in the through hole 331. The connecting rod 53 in which the coil spring 55 is fitted to the outside and the interlocking rod 52 fixed thereto are fitted in the through hole 332.

The tip of the coil spring (first elastic member) is held on side surfaces (step portions) that are reduced from the large diameter portions 51F and 53F of the guide rod 51 and the connecting rod 53 to the small diameter portions 51S and 53S, The rear end is held on the projection side surfaces 36S, 37S of the projections 36, 37, which are spring holding members.

On the other hand, the guide rod 51 and the connecting rod 53 have a structure which can be divided so that the coil springs 54 and 55 can be fitted to the outer side of the small diameter part 51S, 53S.

Inside the movable holder 30, the end of the connecting rod 53 has a large diameter, and the large diameter end 53T of the end can be detached from another part, for example, by fitting a screw groove and a screw groove, etc. do. The position where the step between the large diameter end portion 53T of the connecting rod 53 end and the small diameter portion 53S comes into contact with the pressing portion 40 side surface of the protrusion 37 is supported by the movable holder 30. The distance of the mechanism 20 becomes the furthest distance.

In the guide rod 51, the pressing section 40 is preferably designed to be larger than the small diameter section 51S near the diameter of the through hole 331 (if the middle section 51M is provided). When the compressive force is applied to the coil springs 54 and 55 to move the needle tube 83, and when the spring is restored, the middle diameter portion 51M is provided with the through hole 332 even if the engagement method of the ratchet mechanism coupling described later is changed. This is because the support mechanism 20 can be relatively moved relative to the guide rod 51 more smoothly because it is moved along the

Here, the distance D2, which will be described later, D _m , from which the movable holder 30 falls from the support mechanism 20, is equal to the distance D1 of the linkage rod 52 and the connecting rod 53 before the needle is started. Corresponds. The scanning depth of the injection needle is set by this distance.

Here, the scanning pipe 83 scanning depth of the injection needle 81 is preferable in the range of 0.5-5.5 mm, and it is more preferable in the range of 2.0-3.5 mm.

[Pressing unit]

6 is an explanatory view of the ratchet mechanism in the pressing portion 40. In detail, the exploded view of the pressing section 40 is shown.

In the guide rod 51 and the interlocking rod 52, engaging racks 51r and 52r having inclinations are formed on the circumferential surface of the portion that can be opposed to the pressing portion 40.

The press part 40 is provided with the stopper (plate spring 41) which engages with the engaging rack of the guide rod 51 and the interlocking rod 52. As shown in FIG. On the other hand, in addition to the stopper, the pressing section 40 is provided with a leaf spring supporting rod 42 to which the stopper 41 is fixed, and a case portion 44 covering the stopper 41. The leaf spring support rod 42 is freely moved to the support plate 45 fixed to the pressing portion 40. In addition, a button 42h is provided on the opposite side to which the stopper 41 is fixed, and a compression coil spring 43 is fitted between the button 42h and the support plate from the outside.

Here, the coupling structure of the stopper 41 in the press part 40 and the engaging racks 51r and 52r of the guide rod 51 and the interlocking rod 52 is a ratchet mechanism. That is, the pressing portion 40 is relatively movable in the direction close to the movable holder 30 with respect to the guide rod 51 and the interlocking rod 52, and relatively spaced in the direction away from the movable holder 30 ( Moving in the retraction direction) is locked.

When releasing the position lock of the pressurization part 40, such as when mounting and detaching the syringe 80, press the button 42h against the coil spring 43, so that the stopper 41 and the engaging rack ( 51r, 52r) are released. In detail, it mentions later using FIG. 8 and FIG.

[Contact head]

7A-7C are enlarged views of the abutting head 10. As shown to FIG. 7A-7C, the contact head 10 has the upper surface 13, the side surface 14, and the lower surface 12. As shown in FIG. The upper surface 13 and the lower surface 12 of the contact head 10 are circular, horseshoe-shaped, and polygonal.

7A to 7C, the opening 11 penetrates the upper surface 13 and the lower surface 12 of the abutting head 10. In addition, the needle 11 may pass through the opening 11. In other words, the opening 11 of the abutting head 10 is in contact with the lower surface 12 of the abutting head 10 along the direction in which the needle tube 83 passes in accordance with the movement of the movable holder 30. It penetrates into the bifurcation direction of the head 10 in the up-down direction.

Referring to the side cross-sectional view of FIG. 7A, in the lower surface 12 of the abutting head 10, the surface 12c around the opening 11 is different from the other lower surface (for example, the lower surface projection 12e). It is configured to be located at. When the lower surface 12 is configured in this manner, when the contents are injected into the object, the lower surface 12 partially contacts the object, and the periphery of the opening 11 is in non-contact with the object.

For example, in the case of non-contacting, in the embodiment shown in FIG. 7C, a lower surface protrusion 12e that protrudes continuously in the surface direction of the lower surface is formed in a circumferential portion that is an edge of the lower surface of the circular contact head 10. It is. The top of the columnar lower surface protrusion 12e abuts on the subject to surround the opening 11. On the other hand, the lower surface projection 12e is not limited to a continuous shape, but may be an intermittent shape, such as a bridge shape.

By configuring the lower surface 12 of the abutting head 10 in this manner, a predetermined space is formed between the periphery of the opening 11 and the object under test. Therefore, when liquid such as leakage liquid, blood, or the like leaks from the subject during the injection operation, the liquid spreads and adheres to the lower surface 12 by contacting the lower surface around the opening 11 of the contact head 10. Suppress it.

Moreover, before the operation | movement which puts a needle, and after the operation | movement which takes out a needle, it is comprised so that the front-end | tip of the needle pipe 83 may be located above the part which abuts on the to-be-tested object of the contact head 10 lower surface 12. FIG.

Specifically, the needle tube 83 of the syringe applied to the injection device of the present invention is above the portion where the tip of the needle tube 83 is in contact with the subject under the contact head 10 at the stage before the needle is inserted. In order to be located at, the length of the needle tube 83 is selected and used.

For example, the injection dose can be different at each separate injection site at separate injection depths. The range of injection lengths is defined by the length of the injection path during the retraction of the needle. Therefore, it is foreseen that the total length of the injection will be determined by the length of the injection needle. It is preferable that the total scanning length of an injection needle is 2.0-50 mm, and it is more preferable if it exists in the range of 5.0-40 mm.

In this way, before the needle insertion operation and after the needle extraction operation, the tip of the needle tube 83 of the injection needle 81 does not contact the subject, so that the needle tube is placed on the subject when the injection device falls from the subject. It is possible to prevent the movement in the unexpected direction while the 83 is plugged in. Therefore, the stability of the injection device is improved.

In addition, in operation, the side surface of the lower surface 12 of the abutting head 10 is increased so as to improve contact stability with the subject during operation and increase the space where the opening 11 and the subject become non-contact. The flange part 16 which protrudes from 14 may be provided.

Referring to FIG. 7B, the opening 11 has an elongated hole shape which is elongated and extended toward the support mechanism 20 from a position corresponding to the injection point on the upper surface.

Thus, by forming the shape of the opening part 11 seen from above into an elongate hole shape as mentioned above, the time which can be visually recognized by the scanning operation operator with respect to the needle tube is made clear while the injection direction is performed at the time of performing a scanning operation. As the injection direction becomes clear, the injection operation can be performed at a more accurate position with respect to the target injection point. In addition, when the needle tube 83 can be visually recognized for a long time, it can be found before the transition to the scanning operation when the needle tube 83 has an abnormality such as bending or cutting. Thus, the abnormal scanning operation can be prevented in advance for the subject.

In addition, as the opening 11 in the lower surface 12 of the abutting head 10, the support mechanism 20 is moved from a portion that penetrates in the vertical direction in the passage direction of the needle tube 83 according to the movement of the injection needle. The incision shape which reaches the edge part of the lower surface 12 of the abutting head 10 is formed. Moreover, in the lower part of the support mechanism 20, between two moving guide rails 22 is opened, and the cut shape is formed. By opening the support mechanism 20 and the contact head 10 downward in this manner, the needle tube 83 can be prevented from contacting at a portion when the syringe 80 is attached or detached.

In addition, in this embodiment, it is preferable that the upper surface 13 of the abutting head 10 is a shape such as a trigger shape or a semicircle shape concave inward so as to form an magnifying glass. When the upper surface is composed of a magnifying glass, it becomes easy to visualize the injection site. For example, even when it is difficult to see directly due to the influence of a light source or the like, it is possible to scan while viewing the opening 11 and the needle tube 83 passing through the opening 11 by using a magnifying glass.

In order to make the effect of the said magnifier favorable, the position corresponding to the injection point in the opening part 11 in an upper surface should just be the center of a lower surface (upper surface). In addition, even if the opening 11 is a long hole, the marking 17 may be provided near the center so that the injection point is easily changed.

In addition, the side face 14 of the abutting head 10 is provided with a linear cut to serve as the positioning groove 15. This linear incision is used to visually mark the marking recorded on the subject in the injection preparation step described later. Since the positioning groove 15, which is a cutout for visualizing the marking formed on the side surface 14, has a linear shape, it becomes easy to match the position of the marking head 10 with the marking shown in the implementation method described later. Moreover, there exists an advantage that surface processing becomes easy that a cut part is linear shape.

[Scanning action]

8 is an explanatory diagram of the operation of the injection device 1 according to the first embodiment. 9 is an explanatory diagram of a scanning operation flow according to the first embodiment. Hereinafter, the scanning operation in 1st Embodiment is demonstrated using FIG. 8 and FIG.

In the present embodiment, the contents injection control mechanism 50 controls to inject the contents into the subject, and at the same time, the needle tube 83 is pulled back from the desired depth to the surface of the subject. The flow will be described below.

START: The syringe filled with the injection liquid is set in the injection device. At this time, it sets to the starting position so that the piston 88 and the press part 40 may contact (refer to the implementation method mentioned later).

As a premise, the contact head 10 of the injection device 1 is brought into contact with the subject S at the start. Before the needle insertion operation, each component of the injection device 1 is assumed to be in the state of Fig. 8A. On the other hand, by the shape of the lower surface of the contact head 10 shown in FIG. 7A, the tip of the needle tube 83 is positioned above the portion of the contact head 10 that is in contact with the subject in the lower surface of the contact head 10 at the stage before the needle is inserted. Therefore, the tip of the needle tube 83 does not contact the subject.

S1: The operator manually moves the movable holder 30 toward the abutting head 10 (needle action). At this time, the movable holder 30 moves in the proximity direction (the direction indicated by the arrow) to the abutting head 10, whereby the needle tube 83 of the injection needle 81 is placed close to the subject and put into the subject. Advance (ingress) inside the subject. Here, the coil springs (first elastic members 54 and 55) provided in the movable holder 30 are compressed.

In detail, the pressing part 40 together with the interlocking rod 52 fastened to the movable holder 30 maintains the predetermined distance D _p from the movable holder 30, and is close to the abutting head 10. The distance D _m is shortened (it becomes 0) by moving in the direction of (Fig. 8 (a)-Fig. 8 (b)). Here, since the interlocking rod 52 fastened to the movable holder 30 moves with the movable holder 30, the end part of the press part 40 and the interlocking rod 52 also move together.

In addition, since the pressing part 40 moves with respect to the guide rod 51 which does not move, the fitting part of the guide rod 51 and the pressing part 40 slides in a relatively forward direction (movable holder 30 side). do.

By the relative movement of the pressing section 40, the distance between the movable holder 30 and the pressing section 40 does not change in the operation of inserting the needle. Therefore, by increasing the distance between the movable holder 30 and the pressurizing portion 40, bubbles generated by the depressurization of retreating only the piston 88 are prevented from being mixed. In addition, by shortening the distance between the movable holder 30 and the pressurizing portion 40, the injection operation is prevented from being performed in parallel with the operation in which only the piston 88 is advanced and the needle is inserted.

In S2, when the operator moves in the direction away from the contact head 10 by releasing from the movable holder 30, the needle tube is retracted from the inside of the subject, and the needle is pulled out of the subject and spaced apart from the subject. .

Specifically, when the force in the forward direction applied to the movable holder 30 is released, the movable holder 30 is supported by the restoring force of the coil spring (first elastic member) 54 provided in the movable holder 30. It moves in the direction falling from 20.

Here, the press part 40 is locked by the ratchet mechanism (FIG. 6) which moves to the direction (retraction direction) relatively spaced apart with respect to the rod-shaped members 51 and 52. As shown in FIG. That is, when the movable holder 30 moves in the direction away from the contact head 10, the pressing portion 40 is stopped together with the unfastened guide rod 51, and thus the pressing portion 40 which does not move. ), The interlocking rod 52 fastened to the movable holder 30 moves. That is, in the press part 40, the fitting part slides toward the movable holder 30 side (forward direction) with respect to the interlocking rod 52. As shown in FIG.

By this operation, the distance D _m becomes long and the distance D _p becomes short, so that the needle and liquid injection are performed together (Figs. 8 (b) to 8 (c)). When the movable holder 30 moves in relation to the guide rod 51 at the time of the retracting operation of the movable holder 30, the distance between the movable holder 30 and the pressing portion 40 is shortened. When the distance between the pressurizing portion 40 and the movable holder 30 is shortened (D _p ⇒ D _p ′), the piston 88 is pushed against the syringe 84, so that the volume of the syringe 84 is reduced. This narrows and the liquid inside is injected into a subject. Therefore, an appropriate amount of injection operation can be appropriately performed.

END: The injection device 1 is removed from the subject. At this time, the tip of the needle tube 83 is separated from the subject under the shape of the lower surface of the abutting head 10 shown in FIG. 7A.

With the above configuration and flow, the injection cylinder 84 and the injection needle 81 are properly held in the movable holder 30 when the injection operation is performed. In particular, the flange fitting portion 31 and the needle support stopper 33 restrict the movement of the syringe barrel 84 and the injection needle 81 in the contents injection direction.

Thus, in the case of using a highly viscous gel-like structure as the content to be injected by injection, even if high pressure is applied to the syringe at the time of use, the connection state between the needle and the syringe is not eliminated. Thus, the scanning device 1 can realize a precise scanning operation.

Second Embodiment

Next, 2nd Embodiment is described. The injection device of the second embodiment is preferably applied when the injection operation is performed on a very shallow place of the subject.

In the injection device of the second embodiment, the needle retreat movement (needle pull operation) is performed in two stages after the needle insertion operation. Specifically, in conjunction with an injection operation (content injection operation) by the operation of pressing the piston into the syringe barrel, a needle needle operation is performed in which the needle retreats to a predetermined distance, and thereafter, the needle is moved from the predetermined distance without performing the injection operation. The needle is retracted until it is removed from the surface of the specimen.

10A and 10B are explanatory views of the injection device 2 according to the second embodiment of the present invention, where FIG. 10A is a perspective view and FIG. 10B is a side view. 11A and 11B show an enlarged view of the foot control mechanism of the injection apparatus of FIGS. 10A and 10B. 12 shows a perspective perspective view of the injection device of FIGS. 10A and 10B.

As shown to FIG. 10A-FIG. 12, the injection apparatus 2 of this embodiment is provided with the needle control mechanism 60. As shown in FIG. In the present embodiment, the contents injection control mechanism 50 controls the first stage needle tube retracting operation of retracting the needle tube from the desired depth to a predetermined position while injecting the contents into the subject. The needle control mechanism 60 controls the second stage needle tube retraction operation of retreating the needle tube from a predetermined position to at least the surface of the subject without injecting the contents into the subject.

11A and 11B, the foot control mechanism 60 includes a control plate 61, two positioning pins 62 and 63, two coil springs (second elastic members: 64 and 65), and lock pins. (66,67).

The control plate 61 covers an upper surface portion 24-1 of at least a portion of the support mechanism 20-1 and an upper surface plate 61T covering the rear end side wall 23-1 separated from the contact head 10. ) And back plate 61S.

The two positioning pins 62 and 63 have a large diameter head and are fitted to the side plate 61S of the control plate 61.

The coil springs 64 and 65, which are the second elastic members, are provided on the outer circumference of the positioning pin (fitted from the outside) and held by the side plate 61S of the control plate 61 and the support mechanism 20-1. have.

Two lock pins (elastic pins: 66, 67) are provided on the upper surface of the support mechanism 20-1, and one end thereof is a side surface (guide surface of the circumferential surface holding portion 34-1 of the movable holder 30-1). It is held in). The lock pins 66 and 67 extend in a direction substantially perpendicular to the direction of movement of the syringe 80 (shorter direction of the syringe barrel).

In addition, in this embodiment, the engaging protrusion 39 is formed in the upper surface of the circumferential surface holding part 34-1 of the movable holder 30-1. The distal end of the engaging projection 39 is tapered toward the end, and the lock pins 66 and 67 are slidably in contact with the vertical surfaces (holder side guide surfaces: 39L and 39M) of the distal end. .

The support mechanism 20-1 has an upper surface portion 24-1 and a side wall 23-1, and a guide path for guiding the movement of the movable holder 30-1 is formed therein. As in the first embodiment, the side wall 23-1 of the support mechanism 20-1 is opened so that a part of the movable holder 30-1 is inserted (opening portion 230).

Here, the shape of the support mechanism 20-1 is different from the first embodiment, and the upper surface plate 61T of the control plate 61 is attached to the upper surface portion 24-1 of the support mechanism 20-1. A notch 26 having a concave shape for fitting is formed. The lock pins 66 and 67 are slidably in contact with the moving direction vertical surfaces (support side guide surfaces: 27L and 27M) of the notch portion 26.

In addition, the concave portion, that is, the notched space, with respect to the vertical surfaces 27L and 27M becomes large. Grooves 28L and 28M are formed, respectively.

The lock pins 66 and 67 are elastic elastic pins, which slide along the holder side guide surfaces 39L and 39M of the movable holder 30-1 and along the grooves 61TL and 61TM formed in the top plate 61T. It is movable.

In performing the scanning operation, in the state of FIG. 13A described later, the holder side guide surfaces 39L and 39M are not yet in contact with the lock pins 66 and 67. When the movable holder 30-1 is moved in this state, the lock pins 66 and 67 start to contact the tips of the holder side guide surfaces 39L and 39M, and then move along the holder side guide surfaces 39L and 39M. (Fig. 11A and Fig. 11B, left direction)

And just before it becomes the state of FIG. 13 (b), by the shape of the engagement protrusion 39 which is the convex part of the movable holder 30, the lock pins 66 and 67 are pushed outwards, and the groove part ( 28L, 28M) (Figs. 11A to 11B). After being coupled to the grooves 28L and 28M, the control plate 61 and the movable holder 30-1 are further moved, so that the upper plate 61T of the control plate 61 with respect to the lock pins 66 and 67 is moved. Grooves 61TL and 61TM are moved (Fig. 13 (b) ⇒ (c)).

When the operator releases, first, the movable holder 30-1 moves with the lock pins 66 and 67 engaged with the grooves 28L and 28M (Fig. 13 (c) ⇒ Fig. 13 ( d)). When the predetermined position is reached, the outward direction provided to the lock pins 66 and 67 by the shape of the holder side guide surfaces 39L and 39M of the engaging projection 39 that is the convex portion of the movable holder 30-1. Since the pushing force of is lost, the engagement of the lock pins 66 and 67 and the grooves 28L and 28M is released (FIG. 11B).

Then, the restoring force of the coil springs 64 and 65 as the second elastic member acts, so that the control plate 61 and the movable holder 30-1 move together (Figs. 11B to 11A and 13D). (E)) The retraction operation is completed. At this time, the lock pins 66 and 67 which are released from engagement slide along the vertical surfaces (support side guide surfaces 27L and 27M).

In addition, unlike this 1st Embodiment, in this embodiment, the side wall fixing part 23G for fixing the guide rod 51 and the connecting rod 53 to the side wall 23-1 of the support mechanism 20-1. 23J) is not installed. Instead, the positioning pins 62, 63 in which the second elastic members 64, 65 are fitted to the outside are movably inserted. The pin insertion holes 23P and 23Q are opened.

The side plate 61S of the control plate 61 is opened so that a part of the movable holder 30-1 may be inserted. In this embodiment, the tip of the guide rod 51-1 and the tip of the connecting rod 53-2 are fixed to the side plate 61S of the control plate 61. In the side plate 61S, the side fixing part 61SG which fixes the guide rod 51, and the side fixing part 61SJ which fixes the interlocking rod 52 are formed (refer FIG. 12).

In addition, the positioning pins 62 and 63 in which the second elastic members 64 and 65 are fitted to the outside are inserted in the side plate 61S of the control plate 61 so as to be movable. The side plate pin insertion holes 61SP and 61SQ are opened.

By the operation of inserting the needle, the side plate 61S of the control plate 61 contacts the side wall 23-1 of the support mechanism 20-1. In the first stage needle tube retracting operation, the movable holder 30-1 is retracted with the side plate 61S of the control plate 61 in contact with the side wall 23-1 of the support mechanism 20-1. do. In the second stage needle tube retraction operation, the side plate 61S of the control plate 61 moves away from the side wall 23-1 of the support mechanism 20-1, and the movable holder 30-1 retreats.

[Scanning action]

13 is an operation explanatory diagram of a scanning operation according to the second embodiment. 15A to 15C are explanatory diagrams of a scanning operation flow according to the second embodiment. Hereinafter, the scanning operation in 2nd Embodiment is demonstrated using FIG. 13 and FIG.

START: As a premise, after the injection point and the marking are marked using the injection template (100, see Figs. 16A to 16G) on the subject, the syringe 80 (see Figs. 3A and 3B) is injected into the injection device. (2), the contact head 10-1 of the injection device 2 is brought into contact with the subject.

<Needle tube forward movement>

In S11 of FIG. 14, the operator manually moves the movable holder 30-1 to the abutting head 10 (needle action). When the movable holder 30-1 moves a predetermined distance in the proximal direction to the contact head 10-1, the guide rods 51-1 and the connecting rods 53-2 with respect to the first elastic members 54 and 55 are moved. The compressive force is applied to the first elastic members 54 and 55 from, and the positioning pins 62 and 63 move with the movable holder 30-1 in the proximal direction to the contact head 10-1. That is, in FIG. 13, since the distance D _M becomes short (0 becomes zero) without changing the distance D _P and the distance D _L , a compressive force is applied to the first elastic members 54 and 55 (FIG. 13A) ⇒ (b)).

When the predetermined position is reached, the lock pins 66 and 67 are engaged with the groove portions 28L and 28M of the support mechanism 20.

Thereafter, the positioning pins 62 and 63 and the control plate 61 are in the direction of the abutting head 10-1 in a state where the lock pins 66 and 67 are fitted to the groove portions of the support mechanism 20-1. Move in the forward direction. That is, while the distance D _M does not change from 0 and the distance D _P does not change, the distance D _L becomes short (0 becomes), and the compressive force is not applied to the second elastic members 64 and 65 (Fig. 13 ( b) ⇒ (c)).

Needle needle retraction

In S12 of FIG. 14, the operator has released his hand from the movable holder 30-1. When the movable holder 30-1 is not applied with the force in the proximal direction to the contact head 10-1, the positioning pin 62 by the restoring force of the first elastic members 54 and 55 as the first step. And the positions of the lock pins 66 and 67 do not change, and the movable holder 30-1 moves away from the support mechanism 20-1 and moves in the direction close to the pressing section 40, thereby moving the contents. While injecting into the subject, the needle tube 83 is retracted from a desired depth to a predetermined position. That is, the distance D _M becomes longer and the distance D _P becomes shorter (D _P ') without changing the distance D _L , thereby retreating the predetermined distance and injecting operation (Fig. 13 (c) ⇒ (d)).

As the second step retraction operation of S13 in FIG. 14, the lock pins 66 and 67 are disengaged (released from the fitted state), and the positions of the positioning pins 62 and 63 and the control plate 61 are moved. By the restoring force of the second elastic members 64 and 65, the pressing portion 40 fitted to the movable holder 30-1, the guide rod 51, the connecting rod 53 and the interlocking rod 52 that are in contact with each other is provided. Move. That is, the distance D _M is not changed, the distance D _P until `is to be balchim to, without the injection operation is not involved, the needle tube 83 by non-holding, the distance D _L is longer change from the subject at a predetermined position Retreat (Fig. 13 (d) ⇒ (e)).

By the above-described configuration and flow, in the injection device 2 of the present invention, the injection cylinder 84 and the injection needle 81 are appropriately held in the movable holder 30-1 when the injection operation is performed. In particular, the flange fitting portion 31 and the needle support stopper 33 restrict the displacement in the moving direction of the syringe barrel 84 and the injection needle 81 when the contents are injected.

Therefore, in the case where a highly viscous gel-like structure is used as the content injected by injection, even if high pressure is applied to the syringe at the time of use, the connection state between the injection needle 81 and the syringe 84 Is not solved. Thus, the scanning device 2 can realize a precise scanning operation.

In addition, in this embodiment, since retreat in two steps, a needle is pulled out after an injection operation is complete | finished. Therefore, when a small amount of valuable content such as a cell is injected into a very shallow part of the subject, an injection operation can be realized without the injected contents flowing out from the surface of the subject.

[Application method]

In order to confirm the injection site, the injection direction, etc., the center hole of the injection template 100 was aligned to the center of the injection site before injection (Fig. 15B), and marked with a sterilized oil pen according to six longitudinal holes. (Figure 15 c). In the case where it is desired to repeatedly inject the same portion over a period of time, the injection portion is marked with a dye for art make or the like. When inject | pouring into the part with hairs, such as a scalp, the hair around the injection site is shaved off beforehand. Before injection, the area around the injection site is disinfected, dried and anesthetized.

The syringe 80 is taken out of the package and filled with the injection solution in the syringe barrel 85. In order to set the syringe 80 to the injection device 1, the rear end button 42 of the pressing portion 40 is pushed to the last end opposite to the contact head 10 (FIG. 16A).

While being careful not to contact the needle (the tip of the needle tube) with the injection needle 81 and the piston 88 to which the test agent was inserted, the main body 10, 20 of the injection device 1, etc. It mounts to the movable holder 30 of the injection apparatus 1. Specifically, as shown in Fig. 16B, the syringe 80 is inserted obliquely from the tip of the needle, and the flange (wing) 86 of the syringe barrel 84 is raised and pushed up horizontally (Figs. 16C and 16D). . Then, the flange 86 is rotated to engage the flange fitting portion 31 (FIG. 16E). Thereafter, the pressing portion 40 of the injection device 1 is slowly moved until it comes into contact with the head 88h of the piston 88 to be ready (Fig. 16F, Fig. 16G).

Using the injection device 1 (FIG. 17A) equipped with the syringe 80, the marking marked by the positioning groove of the abutting head 10 and the sterilized oil pen is aligned. In this state, the contact head 10 is reliably put on the scalp (FIG. 17B. START in FIG. 9).

In this state, the movable holder 30 is manually pushed toward the abutting head 10 to insert the needle tube 83 of the injection needle 81 that moves with the movable holder 30 into the scalp (in S1 of FIG. 9). Equivalent). At this time, it confirms that the needle pipe 83 is put in the scalp by visually confirming the opening 11 of the long hole shape of the center part of the contact head 10 from upper direction.

The preparation is then injected into the scalp by slowly releasing the movable holder 30 of the injection device 1 (corresponding to S2 in FIG. 9). After the injection operation is completed, the injection device 1 is removed from the scalp (corresponding to END in FIG. 9).

When a plurality of injections are made in different directions with respect to the same injection site, the injection operation is repeated by fitting the oil pen marking on the skin and the groove 15 provided around the contact head 10 in different directions. By repeating this at 6 places with injection markings, 1.0 mL of test formulation is injected when 1 mL of syringes is used.

After use, the injection device removes and discards the syringe barrel 84 and the injection needle 81, which is cleaned and cleaned, packaged in a separate sterilization pack, and sterilized. Sterilization can be any such as autoclave, EO gas, gamma ray sterilization.

Here, with the above-described configuration, since the syringe barrel 84 and the injection needle 81 remain connected in the injection apparatuses 1 and 2 during the scanning operation period, the contents of the injection apparatuses 1 and 2 are maintained. It can be seen that it rarely leaks into the inside. Therefore, it is sufficient to perform the cleaning or sterilization process mainly on the lower surface 12 of the abutting head 10, and the contamination inside the injection device in which the syringe is assembled is compared with the conventional injection device in which the syringe can be attached or detached. Little consideration is needed.

The contents (material) used for the injection device according to the embodiment of the present invention described above may be selected from the group consisting of cell suspensions, gel materials, therapeutic materials, cosmetic materials, and diagnostic materials. For example, the contents (materials) used in the injection device may be selected from the group consisting of cell suspensions, gelled materials, therapeutic materials, cosmetic materials, and diagnostic materials.

Cosmetic materials to be injected may include, but are not limited to, fat cells such as fillers, hyaluronic acid, Botox (Btx) toxins in the treatment of wrinkles, and the like. Therapeutic agents may include, but are not limited to, antibiotics, anesthetics, analgesics, vaccines, antibodies.

In addition, the injection device of the present invention may be used to inject into a subject a cell in suspension or a cell in a liquid medium as the content contained in a syringe.

In addition, cell suspensions may be mixed with developmental factors as the contents contained within the syringe. Alternatively, the cell suspension may comprise a gelled structure. Such gelled structures preferably exhibit a mixture of extracellular matrix proteins that mimic separate tissue extracellular environments, more preferably gelled structures such as hyaluronic acid.

In addition, an injection device according to an embodiment of the present invention may be used to inject a substance into a subject's separate tissue. In particular, an injection device can be used when injecting cells into the skin as a cell suspension for treating hair loss, alopecia such as alopecia areata, or other symptoms related to hair loss, hair loss and hair loss.

In addition, the injection device of the present invention is preferably used for injecting a liquid such as a medicament, cytokine, and developmental factors into a subject. Thus, the application of liquid to the subject is preferably performed in connection with the treatment of hair loss, alopecia such as alopecia areata, or hair loss, and other symptoms related to hair loss.

Alternatively, an injection device according to an embodiment of the present invention may be used to inject a substance into a subject's muscles or to inject a substance into a subject's tendon.

In addition, the subject to which the injection device according to the embodiment of the present invention is applied is not limited to a human (subject) and may be an animal such as a fish or a rat. Alternatively, the subject may be a tissue such as skin or an organ extracted from the subject, the animal to be tested, or the like.

As mentioned above, although preferred embodiment of this invention was described in detail, this invention is not limited to the specific embodiment mentioned above, A various deformation | transformation and a change are possible within the scope of the present invention described in a claim.

This international application claims priority based on Japanese Patent Application No. 2016-084281, filed April 20, 2016, the entire contents of which are hereby incorporated by reference.

1,2 injection device
10,10-1 butt head
11 opening
12
12c bottom center
14 side
15 Marking Positioning Groove
16 Flange
20,20-1 support mechanism
21 Holder guide path (insertion hole)
22 Operation guide rail
23 Side wall of the support mechanism
230 opening
Top cover of the support mechanism
25 Lower opening of the support mechanism
30,30-1 movable holder
31 flange fitting
32 Ministry of Foreign Affairs
33 needle stand stopper
34 Circumferential surface holding part
35 flat parts
36,37 protrusion (spring holding member)
36S, 37S turning side
38 Adhesive member
310 front holder
320 rear holder
330 movable support
331 first through hole
40 pressurization part (injection control mechanism)
41 stopper (plate spring)
42 leaf spring support rod
42h button
43 Press Spring
44 covers
51,51-1 guide rod
51r combined rack
52 interlocking rods
52r combined rack
53,53-1 connecting rod
Large diameter end of 53T connecting rod
54,55 coil spring (first elastic member)
80 syringes
81 injection needle
82 needle stand
83 needle tube
84 syringes (syringe)
85 External cylinder
86 flange
87 barrel tip
88 piston (plunger)
88h piston head
89 gasket
60 control mechanism
61 control plate
Side plate of 61S control plate
61SG, 61SJ Side Plate Mount
61SP, 61SQ Side Panel Pin Insertion Holes
Top plate of 61T control plate
62,63 positioning pin
64,65 coil spring (second elastic member)
66,67 lock pin
23P, 23Q Pin Insertion Holes
Upper part of 24-1 support mechanism
26 notch
27L, 27M Vertical Surface (Support Side Guide Surface)
28L, 28M Groove
39 Coupling protrusion
39L, 39M vertical surface (holder side guide surface)
100 Injection Template

Claims (23)

An injection device for injecting contents into a subject by a syringe having a piston, a syringe into which the piston is fitted, a needle holder connected to the syringe and a needle needle inserted into the subject,
An abutting head which is in contact with the subject and has an opening through which the needle tube passes;
A movable holder holding said syringe and said injection needle,
A support mechanism fixed to the abutting head;
A content injection control mechanism for pushing the piston into the syringe;
The movable holder moves along the support mechanism to move the syringe barrel and the injection needle relative to the abutting head,
And the syringe is detachable to the injection device. The method of claim 1,
The contents injection control mechanism includes a pressing portion for pushing the piston into the syringe,
By moving the movable holder in the advancing direction proximate to the contact head, the needle tube is inserted into the subject to enter the inside of the subject,
By moving the movable holder in the retracting direction away from the abutting head, the movable holder is moved back toward the pressurizing portion while the needle holder is retracted with respect to the subject, and the piston is pushed into the syringe to move the contents. An injection device, which is injected into a subject. The method of claim 2,
The injection cylinder includes an outer cylinder portion for accommodating the contents, and a flange provided at a rear end of the outer cylinder portion,
The movable holder includes a flange fitting portion to be held by fitting to the flange,
And the flange fitting portion restricts the flange from moving in the retracting direction with respect to the movable holder. The method of claim 3,
The movable holder includes an outer cylinder portion clamping portion for holding and holding the outer cylinder portion by projections standing up along both sides of the outer cylinder portion.
And the outer cylinder portion clamping portion regulates lateral displacement of the outer cylinder portion with respect to the movable holder. The method of claim 2,
The movable holder includes a needle support stopper for stopping and holding the movement of the injection needle by a projection abutting against the tip end of the needle support,
And said needle bearing stopper regulates said forward direction movement of said needle bearing relative to said movable holder. The method of claim 2,
The movable holder includes a circumferential surface holding portion for holding the needle base in a circumferential surface shape,
And the circumferential surface holding portion regulates the lateral displacement of the needle base relative to the movable holder. The method of claim 2,
The contents injection control mechanism,
A guide rod movably coupled to the movable holder and the pressing unit;
An interlocking rod coupled to the movable holder and movably coupled to the pressing unit;
An injection apparatus, comprising: a connecting rod extending on the same straight line as the interlocking rod, and having a rear end facing and distal to the front end of the interlocking rod, wherein the rear end is positioned inside the movable holder. The method of claim 7, wherein
The linkage rod and the guide rod includes a coupling rack having an inclination on the circumferential surface of the portion facing the pressing portion,
The pressing unit includes a stopper engaged with the coupling rack of the interlocking rod and the guide rod,
The pressurizing portion is capable of relative movement with respect to the interlocking rod and the guide rod in a direction of pushing the piston into the syringe barrel in proximity to the movable holder, and the ratchet mechanism of which movement is locked in a direction away from the movable holder. An injection device comprising: The method of claim 7, wherein
The first elastic member is provided in the movable holder,
The movable holder has a first through hole through which the guide rod is slidably inserted into a lower portion of the holding portion of the syringe, and the connecting rod is slidably inserted into a distal end thereof, and the interlocking rod is fastened to a rear end of the same straight line. And a moving support formed with a second through hole formed therein,
When the movable holder moves in the forward direction close to the abutting head, a compressive force is applied to the first elastic member from the guide rod and the connecting rod with respect to the first elastic member, so that the first elastic member And the movable holder is moved in a direction away from the support mechanism by a restoring force. The method of claim 9,
Inner walls of the first through hole and the second through hole are provided with a spring holding member protruding from the inner wall,
The guide rod and the connecting rod are each provided with a small diameter portion and a large diameter portion,
The small diameter portion is located near the center of the movable holder in the extending direction of the guide rod and the connecting rod, the large diameter portion is located at the tip side of the movable holder,
An injection device characterized in that the front end of the first elastic member is held on the side of the guide rod and the connecting rod reduced in diameter from the large diameter portion to the small diameter portion, and the rear end of the first elastic member is held in the spring holding member . The method of claim 10,
The rear end side wall of the support mechanism is opened so that a part of the movable holder is inserted and the tip of the guide rod and the tip of the connecting rod are fixed.
When the movable holder moves in a forward direction proximate to the abutting head, the sidewall of the support mechanism abuts on a part of the movable holder such that the movable holder moves in the forward direction toward the abutting head. To stop,
When the movable holder moves in the retraction direction away from the abutting head by the restoring force of the first elastic member, the contents are injected into the subject and the needle tube is retracted from the desired depth to the surface of the subject to be tacked. Injection device characterized in that the. The method of claim 11,
The support mechanism has a cover covering at least in the circumferential direction the holding portion of the injection needle and the movable holder at least in the circumferential direction from above and to the side, so that the movable holder is inserted into the support mechanism. Injection device. The method of claim 2,
The injection device further comprises a needle control mechanism,
The contents injection control mechanism is a first stage needle for injecting the contents into the test object by pushing the piston into the syringe in close proximity to the pressing portion while the needle tube is retracted to a desired position with respect to the test object. Control tube retraction,
And the needle control mechanism controls a second stage needle tube retracting operation of retreating the needle tube from a predetermined position to at least the surface of the subject without injecting the contents into the subject. . The method of claim 13,
The needle control mechanism,
A control plate having an upper surface plate covering an upper surface of at least a portion of the support mechanism, and a side plate covering a rear end side wall away from the abutting head,
Two positioning pins having a large diameter head and inserted into the side plate of the control plate;
A second elastic member fitted to an outer side of the positioning pin and installed in contact with the side plate of the control plate and the support mechanism;
It is provided on the upper surface of the support mechanism, one end is held on the side of a portion of the peripheral surface holding portion of the movable holder, and includes two elastic pins installed to extend in a substantially vertical direction with respect to the syringe,
The support mechanism has a top surface and a side surface and is formed with a guide path for guiding the movement of the movable holder,
On the upper surface of the support mechanism, two groove portions to which the elastic pin is fitted are formed,
An injection device, wherein an insertion hole is formed in the side surface of the support mechanism, the insertion hole being an inlet of the guide path into which the positioning pin with the second elastic member fitted to the outside is inserted. The method of claim 14,
The contents injection control mechanism,
A guide rod movably coupled to the movable holder and the pressing unit;
An interlocking rod coupled to the movable holder and movably coupled to the pressing unit;
Extends on the same straight line as the interlocking rod, the rear end of the interlocking rod is opposite to the front end of the interlocking rod, and the rear end includes a connecting rod positioned inside the movable holder,
The rear end side wall of the support mechanism is opened to insert a portion of the movable folder,
The side plate of the control plate is opened so that a part of the movable holder is inserted, the tip of the guide rod and the tip of the connecting rod is fixed,
When the movable folder moves in a forward direction close to the abutting head, after the side plate of the control plate is in contact with a part of the movable holder, the side plate of the control plate is in contact with the side surface of the support mechanism, Stop the movable holder from moving in the forward direction toward the abutting head,
In the first step of the needle tube retracting operation, the movable holder moves in the retracting direction while the movable holder approaches the pressing part while the side plate of the control plate is in contact with the side surface of the support mechanism.
In the second needle tube retracting operation, the side plate of the control plate moves away from the side surface of the support mechanism, and the movable holder moves in the retracting direction while the movable holder maintains a predetermined distance from the pressing portion. An injection device, characterized in that. The method of claim 15,
In the foot control mechanism,
The first elastic member is provided in the movable holder,
When the movable holder moves a predetermined distance in a direction toward the contact head, a compressive force is applied to the first elastic member installed inside the movable holder from the guide rod and the connecting rod with respect to the first elastic member. After being
After the elastic pin moves together with the movable holder in a direction toward the contact head to reach a predetermined position, the elastic pin is coupled to the groove part.
And the positioning pin and the control plate move in the direction of the abutting head while the elastic pin is fitted to the groove portion of the support mechanism, and a compressive force is applied to the second elastic member. . The method of claim 16,
When no force in the direction in which the movable holder is approached toward the abutting head is applied,
As a first step, by the restoring force of the first elastic member, the position of the positioning pin and the elastic pin does not change, and the movable holder moves in a direction close to the pressing part as a direction away from the support mechanism. Retracting the needle tube from the desired depth to a predetermined position while injecting the contents into the subject,
As a second step, the elastic pin is separated to move the position of the positioning pin and the control plate, thereby moving the pressing portion fitted to the movable holder and the guide rod by the restoring force of the second elastic member, And the needle tube is retracted from a desired depth to a predetermined position. The method of claim 1,
The lower surface of the abutting head is configured such that the surface around the opening is positioned inward with respect to the other lower surface,
And when the contents are injected into the subject, the lower surface partially contacts the subject and the periphery of the opening is in contact with the subject. The method of claim 18,
Projections protruding in the direction of the surface of the lower surface continuously or intermittently at an edge portion of the lower surface of the abutting head,
An upper surface of the projection is in contact with the subject so as to surround the periphery of the opening. The method of claim 18,
An injection apparatus, characterized in that the tip of the needle tube is located above the portion of the contact head that is in contact with the subject under the contact head before the needle insertion operation is started and after the needle extraction operation is finished. The method of claim 1,
The opening portion of the abutting head penetrates in the direction of the needle tube passing along the movement of the movable holder with respect to a lower surface of the abutting head, and in a bifurcation direction in the vertical direction of the abutting head,
The said opening part in the upper surface of the said contact head is an elongate hole shape open | released elongately extended toward the said support mechanism from the position corresponding to an injection point. The method of claim 1,
The supporting device is provided with an injection guide rail having a circumferential surface for slidably supporting at least a part of the movable holder. The method of claim 22,
The lower part of the moving guide rail of the support mechanism is opened so that the needle tube does not come into contact when the syringe is attached or detached,
On the lower surface of the contact head, from the portion penetrating in the vertical direction in the direction through which the needle tube passes along the movement of the movable holder as the opening portion, the edge portion of the lower surface of the contact head toward the support mechanism. An injection device characterized in that an incision shape leading to it is formed.

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