WO2017176039A1 - Système et procédé de diagnostic de lésions pigmentées - Google Patents

Système et procédé de diagnostic de lésions pigmentées Download PDF

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Publication number
WO2017176039A1
WO2017176039A1 PCT/KR2017/003703 KR2017003703W WO2017176039A1 WO 2017176039 A1 WO2017176039 A1 WO 2017176039A1 KR 2017003703 W KR2017003703 W KR 2017003703W WO 2017176039 A1 WO2017176039 A1 WO 2017176039A1
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Prior art keywords
laser
target
pigmented
lesion
irradiated
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PCT/KR2017/003703
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English (en)
Korean (ko)
Inventor
변성현
민완기
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스페클립스 주식회사
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Priority claimed from KR1020160115675A external-priority patent/KR20170114229A/ko
Application filed by 스페클립스 주식회사 filed Critical 스페클립스 주식회사
Priority to US15/540,366 priority Critical patent/US20180085004A1/en
Publication of WO2017176039A1 publication Critical patent/WO2017176039A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings

Definitions

  • the present invention relates to a diagnostic system and method for pigmented lesions.
  • the present invention is supported by the following national research and development projects.
  • Pigmented lesions can be classified into benign lesions and malignant lesions as one of skin diseases.
  • Benign lesions can be, for example, freckles or nevus of Ota, and malignant lesions can be such as skin cancer.
  • benign lesions are mainly removed by laser using a skin toning device or skin peeling device, and the wavelength of the laser used varies depending on the position (depth from the skin) of the benign lesions.
  • a system and method for diagnosing pigmented lesions that can determine the depth and / or thickness of the pigmented lesion.
  • the laser type of the wavelength to remove the benign lesion to the user, and to tell the user the progress and the critical degree of the malignant lesion
  • the acoustic sensing unit for detecting a photoacoustic wave generated when the first laser is irradiated to the target having a pigmented lesion;
  • a disease diagnosis unit determining a type of the pigmented lesion on the basis of the generated light generated when the second laser is irradiated onto the target;
  • a pigmented lesion diagnosis unit configured to calculate at least one of a depth and a thickness of the pigmented lesion based on the time at which the photoacoustic wave is detected and the laser irradiation time information on the first laser irradiated to the target. It is to provide, a diagnostic system for pigmented lesions is provided.
  • the step of irradiating the first laser to the target having a pigmented lesion Detecting a photoacoustic wave generated from a target to which the first laser is irradiated; Calculating the depth and / or thickness of the pigmented lesion based on laser irradiation time information and the acoustic detection time at which the photoacoustic wave is detected; Determining a type of pigmented lesion by analyzing a spectrum of generated light generated when the second laser is irradiated onto the target; And determining the type of the laser lesion corresponding to the depth of the pigmented lesion when the pigmented lesion is determined to be a benign lesion as a result of determining the type of the pigmented lesion.
  • a laser type with a wavelength capable of removing benign lesions based on the depth and / or thickness of the pigmented lesion may be recommended to the user.
  • the type of laser that is present is recommended and, if diagnosed as malignant lesions, the progress of malignant lesions can be indicated.
  • FIG. 1 is a view for explaining a diagnosis system of pigmented lesions according to an embodiment of the present invention.
  • FIG. 2 is a view for explaining a method for calculating the depth of the pigmented lesion in the diagnosis system of the pigmented lesion according to an embodiment of the present invention.
  • FIG. 4 is a view for explaining a diagnosis system for pigmented lesions according to another embodiment of the present invention.
  • FIG. 5 is a view for explaining a diagnosis system of the pigmented lesion according to another embodiment of the present invention.
  • FIG. 6 is a view for explaining a diagnosis system for pigmented lesions according to another embodiment of the present invention.
  • FIG. 7 is a view for explaining a method for diagnosing pigmented lesions according to an embodiment of the present invention.
  • component A and / or component B' is used to mean 'at least one of component A and component B'.
  • indirect coupling means that at least one third component is placed and coupled between the component A and the component B.
  • ... unit As used herein, the terms “... unit”, “... unit”, “module” and the like refer to a unit that processes at least one function or operation, which may be implemented by hardware or software or a combination of hardware and software. .
  • the term 'transmission', 'communication', 'transmission', 'receive', 'providing', or 'delivering' of a signal, data, or information means one component ('component' In addition to the direct transmission of signals, data, or information from a ') to another component (' component b '), it also passes to at least one other component (' component c ') to component b. Included.
  • component a outputs from component b, even if there is no explicit representation that one component ('component a') and another component ('component b') are 'operationally related' to each other. Receive the signal, data, or information directly or through at least one other component to perform its own (component a) operation, or the component b directly outputs the signal, data, or information outputted from the component a. Alternatively, it is to be understood that component a and component b are 'operationally related' if they are receiving through another at least one component and performing their own (component b) operation.
  • the 'laser generating device' means a device for generating a cosmetic or medical laser
  • the 'beauty or medical laser handpiece' has a shape that can be held by the user hand
  • the laser generated by the laser generating device Means a device configured to receive the inflow and outflow to the target.
  • the term 'laser' means a pulsed laser or continuous light laser.
  • the frequency band of the 'laser' may have any frequency band, for example, may have a UV (ultra violet) band, a visible light band, or an IR-infrared band.
  • 'generating light' is meant to include all light generated when a laser is irradiated to a target (eg, body tissue).
  • 'generated light' may mean, for example, plasma light, reflected light, scattered light, and / or fluorescent light.
  • the term 'wavelength' means a specific value or a specific range of values (ie, a wavelength band).
  • the term 'first laser' means a laser irradiated onto a target to obtain a photoacoustic wave or photoacoustic wave couple used to calculate the depth and / or thickness of a pigmented lesion.
  • the term 'second laser' means a laser irradiated to a target to obtain generated light for determining the type of pigmented lesion.
  • the term 'third laser' means a laser that is irradiated to a target to obtain an image of a pigmented lesion.
  • 'laser' when it is not necessary to distinguish between 'first laser', 'second laser', and 'third laser', the term 'laser' may be referred to without any distinction.
  • the first laser and the second laser may be the same, or the first laser and the second laser may be lasers irradiated onto the target at different times.
  • the first laser and the third laser may be the same, or the first laser and the third laser may be lasers irradiated onto the target at different times.
  • the second laser and the third laser may be the same, or the second laser and the third laser may be lasers irradiated onto the target at different times.
  • the first laser and the second laser may be the same, or the first laser and the second laser may be lasers irradiated onto the target at different times.
  • the first laser, the second laser, and the third laser are the same, or the first laser, the second laser, and the third laser are each targeted at different times. It may be a laser irradiated to.
  • FIG. 1 is a view for explaining a diagnosis system of pigmented lesions according to an embodiment of the present invention.
  • a diagnosis system for pigmented lesions may include a laser generating device 1, a light collecting unit 2, and a cosmetic or medical laser handpiece (hereinafter referred to as a handpiece) ( 3) and a diagnosis apparatus (hereinafter, 'diagnosis apparatus') 10 for pigmented lesions.
  • the diagnostic apparatus 10 includes a spectroscope 4, an acoustic sensor 5, a diagnostic 7, a pigmented lesion DB storage 11, a laser type DB storage 12, a reference spectrum DB storage for disease diagnosis ( 13) and a spectral data comparison unit 14.
  • the diagnosis unit 7 includes a pigmented lesion diagnosis unit 7a and a disease diagnosis unit 7b.
  • acoustic sensing result is used to mean “a sound sensing time” or “data capable of calculating the sound sensing time”.
  • the first laser for acquiring the photoacoustic wave and the second laser for acquiring the generated light are the same laser. Therefore, in the present embodiment described with reference to FIG. 1, the first laser and the second laser will be referred to as 'lasers' without being distinguished.
  • the sound detector 5 may detect sound generated when the laser is irradiated to a target (for example, skin) to check the depth and / or thickness of the pigmented lesion.
  • the acoustic detector 5 may include a transducer for converting sound into an electrical signal and an amplifier for amplifying the electrical signal converted by the transducer for sound sensing. .
  • the pigmented lesion present in the target absorbs the laser and generates sound.
  • a photoacoustic Sound generated by the photoacoustic phenomenon is referred to herein as a 'photoacoustic wave'.
  • the pigmented lesion diagnosis unit 7a determines the depth of the pigmented lesion based on the time when the photoacoustic wave is detected by the sound sensor 5 ('sound detection time') and the laser irradiation time information. Can be calculated
  • the laser generation time may be a control unit (not shown) for controlling the laser generation operation of the laser generation device 1 or the laser generation device 1.
  • the time when the laser hits the surface of the target may be obtained by an apparatus (eg, a photodiode) that detects the laser near the surface of the target, and the time when the generated light is detected Can be obtained by (2). At least one or more of the obtained times is provided to the pigmented lesion diagnosis unit 7a.
  • the acoustic detector 5 detects a photoacoustic wave generated from the target when the laser is irradiated to the target, and the acoustic detection result is provided to the pigmented lesion diagnosis unit 7a.
  • the acoustic detector 5 detects one or more photoacoustic waves, and the pigmented lesion diagnosis unit 7a calculates the depth and / or thickness of the pigmented lesion using the acoustic detection time and the laser irradiation time information.
  • the pigmented lesion diagnosis unit 7a is provided with the acoustic sensing result from the acoustic sensing unit 5 and calculates the depth and / or thickness of the pigmented lesion using the acoustic sensing result and the laser irradiation visual information.
  • the sound detector 5 may detect at least two photoacoustic waves.
  • a first photoacoustic wave when a first laser is irradiated to a target, the first sensed in time is called a first photoacoustic wave, and the next sensed is called a second photoacoustic wave.
  • the first photoacoustic wave and the second photoacoustic wave satisfy the following conditions, it will be referred to as a 'photoacoustic wave couple'.
  • the first photoacoustic wave and the second photoacoustic wave are sequentially sensed, and the time when the first photoacoustic wave is detected and the time when the second photoacoustic wave is detected are mutually different.
  • the first photoacoustic wave is generated when the first laser is absorbed by the upper surface of the pigmented lesion (surface close to the surface of the target), and the second photoacoustic wave is caused by the lower surface of the pigmented lesion (far from the surface of the target). Is generated when the laser is absorbed by the laser beam).
  • a first photoacoustic wave is generated when the laser is absorbed to the upper surface hs of the pigmented lesion, and the lower surface of the pigmented lesion (Ls).
  • Ls the lower surface of the pigmented lesion
  • a second photoacoustic wave is generated when the laser is absorbed. Since these photoacoustic waves are in a photoacoustic wave couple relationship, the thickness d of the pigmented lesion can be calculated.
  • the laser beam is spaced a predetermined distance S as shown in FIG. 3 rather than being irradiated to the center of the pigmented lesion.
  • a laser is irradiated around the pigmented lesion.
  • the pigmented lesion diagnosis unit 7a may calculate the thickness of the pigmented lesion from the detection result of the photoacoustic wave couple.
  • the pigmented lesion diagnosis unit 7a selects one or more laser types capable of treating the pigmented lesion with reference to the laser type DB.
  • the term 'laser type' is data defining a laser, which data defines the laser by at least one of wavelength, power, pulse width, and product name.
  • the pigmented lesion diagnosis unit 7a selects at least one laser type corresponding to the depth and / or thickness of the pigmented lesion from the laser type DB.
  • the pigmented lesion diagnosis unit 7a may select at least one laser type in consideration of the depth of the pigmented lesion, or at least one laser type in consideration of both the depth and thickness of the pigmented lesion. .
  • the pigmented lesion diagnosis unit 7a may also determine the development state of the pigmented lesion with reference to the pigmented lesion DB when the pigmented lesion is a malignant lesion.
  • the malignant lesion may be, for example, skin cancer
  • the pigmented lesion DB is data defining a progression state according to the depth and / or thickness of the malignant lesion.
  • the wavelength of the laser that treats pigmented lesions depends on the location of the pigmented lesion, for example, Q-switched Ruby lasers (694 nm) and Q-switched Alexandrite lasers (755nm) can treat pigmented lesions on the upper epidermis.
  • Q-switched Nd: YAG laser (532 nm) can treat pigmented lesions present in the epidermis
  • Q-switched Nd: YAG laser (1064 nm) can treat pigmented lesions present in the dermis.
  • the pigmented lesion diagnosis unit 7a may determine the progress state according to the depth and / or thickness of the pigmented lesion by referring to the pigmented lesion DB as described above. For example, the pigmented lesion diagnosis unit 7a may determine the advanced state according to the thickness of the pigmented lesion, or may determine the advanced state in consideration of both the depth and the thickness of the pigmented lesion.
  • Data defining progression status may be, for example, the stage of development (first stage, second stage, third stage, fourth stage) of cancer.
  • the pigmented lesion DB and the laser type DB described above are included in the diagnostic apparatus 10 as shown in FIG. 1 or separately in an external storage device (not shown) accessible by the pigmented lesion diagnosis unit 7a by wire or wirelessly. It may be stored.
  • the pigmented lesion diagnosis unit 7a can access and refer to the pigmented lesion DB and the laser type DB stored in the external storage device.
  • an operation result of the pigmented lesion diagnosis unit 7a may be displayed through a display unit such as a monitor.
  • a display unit such as a monitor.
  • the laser type selected by the pigmented lesion diagnosis unit 7a or the progress state of the pigmented lesion may be displayed on the display unit (not shown).
  • the pigmented lesion diagnosis unit 7a performs the operation of selecting the laser type when the pigmented lesion is a benign lesion and the operation of determining the progress state when the pigmented lesion is a malignant lesion.
  • the disease diagnosis unit 7b may determine the type of pigmented lesion.
  • the disease diagnosis unit 7b may be configured to determine whether the pigmented lesion is a malignant lesion by analyzing a spectrum of generated light generated from the pigmented lesion when the laser is irradiated to the pigmented lesion.
  • the photoacoustic wave is detected by the acoustic sensor 5 and provided to the pigmented lesion diagnosis unit 7a.
  • the light collecting unit 2 collects such generated light and provides it to the spectrometer 4.
  • the spectrometer 4 measures the spectrum of generated light.
  • the spectral data comparison unit 14 compares the spectrum of generated light measured by the spectroscope with the reference spectrum DB for disease diagnosis.
  • the disease diagnosis unit 7b determines whether the pigmented lesion is a malignant lesion or a benign lesion based on the comparison result of the spectral data comparison unit 14. The determination result of the disease diagnosis unit 7b is provided to the pigmented lesion diagnosis unit 7a.
  • the disease diagnosis unit 7b may determine that the pigmented lesion is a malignant lesion when the spectrum of the generated light and the reference spectrum DB for disease diagnosis are the same or nearly similar.
  • Korean Patent Publication No. 10-1640202 (July 11, 2016) discloses a technique for determining whether a disease is obtained using a spectral spectrum of generated light. Please refer to the contents disclosed in Korea Patent Publication No. 10-1640202 (July 11, 2016). On the other hand, the contents disclosed in Korea Patent Publication No. 10-1640202 (July 11, 2016) is incorporated as part of the present specification.
  • the first laser and the second laser are irradiated to the target at different times. That is, when the first laser generated by the laser generating device 1 is irradiated to the target, the sound sensor 5 detects the photoacoustic wave. When the second laser generated visually later than the first laser by the laser generating device 1 is irradiated to the target, the light collecting unit 2 collects generated light generated from the target.
  • the second laser is irradiated to the target visually faster than the first laser. That is, when the second laser generated by the laser generating device 1 is irradiated to the target, the light collecting unit 2 collects the generated light generated from the target. On the other hand, when the first laser generated by the laser generation device 1 visually later than the second laser is irradiated to the target, the sound sensor 5 detects the photoacoustic wave.
  • the light collecting unit 2 is not included in the diagnosis apparatus 10 for pigmented lesions, which is illustrative, and the light collecting unit 2 is used for diagnosing the pigmented lesion 10. It is also possible to be configured to include). In addition, any of the components included in the diagnosis apparatus 10 of the pigmented lesion, for example, the acoustic sensing unit 5 may be configured so that the diagnosis apparatus 10 of the pigmented lesion is not included.
  • FIG. 2 is a view for explaining a method for calculating the depth of the pigmented lesion in the diagnosis system of the pigmented lesion according to an embodiment of the present invention.
  • the depth (i.e. position) of a pigmented lesion is determined from the surface of the pigmented lesion (e.g., the surface (top, bottom, or side) of the pigmented lesion or the interior of the pigmented lesion.
  • the distance h to an arbitrary position) see FIG. 2 (a)).
  • the depth (h) of the pigmented lesion is shown as a distance to the center of the pigmented lesion, but this is exemplary.
  • the pigmented lesion diagnosis unit 7a can calculate the depth of the pigmented lesion by, for example, the following ⁇ Formula 1>.
  • the acoustic detection time is a time when the photoacoustic wave generated from the pigmented lesion is detected.
  • a photoacoustic wave having a peak relatively higher than the surroundings may be generated from the pigmented lesion, as shown in (b) of FIG.
  • dye lesion diagnosis part 7a can calculate the thickness of a pigment
  • the first photoacoustic wave and the second photoacoustic wave are photoacoustic wave couples.
  • all or part of the components included in the diagnosis device 10 of the pigmented lesion may be configured to be coupled to the handpiece 3.
  • the acoustic sensing unit 5 and / or the light collecting unit 2 is coupled to a handpiece detachable device (not shown in FIG. 1), and such handpiece detachable device is detachable from the handpiece 3. Possibly combined.
  • the acoustic sensing unit 5 and / or the light collecting unit 2 may be embedded in the handpiece 3.
  • FIG. 4 is a view for explaining a diagnosis system for pigmented lesions according to another embodiment of the present invention.
  • a diagnosis system for a pigmented lesion may include a laser generating device 1, a light collecting unit 2, a cosmetic or medical laser handpiece 3, and a diagnosis device for a pigmented lesion ( 10).
  • the diagnostic apparatus 10 includes a spectroscope 4, an acoustic sensor 5, a diagnostic 7, a pigmented lesion DB storage 11, a laser type DB storage 12, a reference spectrum DB storage for disease diagnosis ( 13), the spectral data comparison unit 14, and the light sensing unit 19.
  • the diagnosis unit 7 includes a pigmented lesion diagnosis unit 7a and a disease diagnosis unit 7b.
  • This embodiment described with reference to FIG. 4 differs from the embodiment described with reference to FIG. 1 in that the laser sensing visual information is obtained by the light sensing unit 19 and provided to the pigmented lesion diagnosis unit 7a.
  • the embodiment of FIG. 4 will be described based on differences from the embodiment of FIG. 1.
  • the first laser for acquiring the photoacoustic wave and the second laser for acquiring the generated light are the same laser. Accordingly, in the present embodiment described with reference to FIG. 4, the first laser and the second laser will be referred to as 'lasers' without being distinguished.
  • the acoustic sensing unit 5 may detect the photoacoustic wave generated when the laser is irradiated to the target with the pigmented lesion.
  • the light detector 19 may detect the generated light generated from the target after the laser is irradiated to the laser or the target that generated the photoacoustic wave detected by the acoustic detector 5.
  • the light sensing unit 19 may be implemented by a device such as a photodiode, for example.
  • the light detector 19 detects a laser moving through the inside of the handpiece 3, detects a laser output from the handpiece 3 and moves to a target, or detects a generated light generated from the target. It can be configured to.
  • the light sensing unit 19 may be formed inside the handpiece 3 or the handpiece 3. Can be coupled to the outside.
  • the light sensing unit 19 When the light sensing unit 19 is configured to detect a laser moving through the interior of the handpiece 3, at least a part of the laser moving inside the handpiece 3 branches to the light sensing unit 19 side.
  • An optical element (not shown in FIG. 4) may be located inside the handpiece 3.
  • the light detector 19 When the light detector 19 is configured to detect a laser output from the handpiece 3 and move to the target, or to detect the generated light generated from the target, the light detector 19 is configured to It may be located adjacent to a part (part in contact with the target) or in a handpiece detachable device (not shown in FIG. 4) which is removably coupled to the handpiece 3.
  • the pigmented lesion diagnosis unit 7a may calculate the depth and / or thickness of the pigmented lesion based on the time when the photoacoustic wave is detected by the acoustic detector 5 and the laser detection result by the light detector 19. Can be.
  • the 'laser detection result' includes 'laser irradiation time information'.
  • the pigmented lesion diagnosis unit 7a may select the laser type and / or the advanced state based on the depth and / or the thickness of the pigmented lesion.
  • the first laser and the second laser are irradiated to the target at different times. That is, when the first laser generated by the laser generating device 1 is irradiated to the target, the sound sensor 5 detects the photoacoustic wave.
  • the second laser generated visually later than the first laser by the laser generating device 1 is irradiated to the target, the light collecting unit 2 collects generated light generated from the target.
  • the second laser is irradiated to the target visually faster than the first laser. That is, when the second laser generated by the laser generating device 1 is irradiated to the target, the light collecting unit 2 collects the generated light generated from the target.
  • the sound sensor 5 detects the photoacoustic wave.
  • the light sensing unit 19 is configured to sense the generated light or the first laser generated from the target by the first laser.
  • FIG. 5 is a view for explaining a diagnosis system of the pigmented lesion according to another embodiment of the present invention.
  • a diagnosis system for pigmented lesions may include a laser generator 1, a light collecting unit 2, a cosmetic or medical laser handpiece 3, and a diagnosis apparatus for pigmented lesions 10. ), And an image collecting unit 16.
  • the diagnostic apparatus 10 includes a spectroscope 4, an acoustic sensor 5, a diagnostic 7, a pigmented lesion DB storage 11, a laser type DB storage 12, a reference spectrum DB storage for disease diagnosis ( 13), the spectrum data comparison unit 14, a disease diagnosis reference image DB storage unit 17, an image comparison unit 18, and a light detector 19.
  • the diagnosis unit 7 includes a pigmented lesion diagnosis unit 7a and a disease diagnosis unit 7b.
  • the first laser for acquiring the photoacoustic wave, the second laser for acquiring the generated light and the third laser for acquiring the image of the pigmented lesion are the same laser. . Therefore, in the present exemplary embodiment described with reference to FIG. 5, the first laser, the second laser, and the third laser will be referred to as 'lasers' without being distinguished.
  • the embodiment described with reference to FIG. 5 is different from the embodiment described with reference to FIG. 1 in that the disease diagnosis unit 7b determines the disease in consideration of both the spectrum of generated light and the image of the pigmented lesion.
  • the embodiment of FIG. 5 will be described based on differences from the embodiment of FIG. 1.
  • the acoustic sensing unit 5 may detect a photoacoustic wave generated when the laser is irradiated to a target for checking the depth and / or thickness of the pigmented lesion.
  • the pigmented lesion diagnosis unit 7a calculates the depth and / or thickness of the pigmented lesion based on the time at which the photoacoustic wave is detected by the sound sensing unit 5 and the laser irradiation time information, and the laser type and / or progression. The state can be determined.
  • the image collector 16 may collect an image of the target when the laser is irradiated to the target or may collect an image of the target when the laser is not irradiated to the target.
  • the image comparison unit 18 compares the image collected by the image collection unit 16 with the reference image DB for disease diagnosis.
  • the spectral data comparison unit 14 compares the spectrum of generated light measured by the spectroscope 4 with the reference spectrum DB for disease diagnosis.
  • the comparison result of the image comparison unit 18 and the comparison result of the spectral data comparison unit 14 are provided to the disease diagnosis unit 7b, and the disease diagnosis unit 7b refers to the image comparison result and the spectral data comparison result. Determine the type of pigmented lesion by reflecting.
  • the disease diagnosis unit 7b determines the type of the pigmented lesion by reflecting at least one of the comparison result of the spectral data comparison unit 14 and the comparison result of the image comparison unit 18.
  • the disease diagnosis unit 7b may include i) the same or extremely similar to the spectrum data of the generated light in the reference spectrum data DB for disease diagnosis, or ii) the image of the pigmented lesion in the reference image DB for disease diagnosis. If there is the same or very similar to, it is determined that the pigmented lesion is a malignant lesion.
  • the disease diagnosis unit 4b includes i) the same or extremely similar to the spectrum data of the generated light in the reference spectrum data DB for disease diagnosis, and ii) the image of the pigmented lesion in the reference image DB for disease diagnosis. If there is the same or very similar to, it is determined that the pigmented lesion is a malignant lesion.
  • Korean Patent Publication No. 10-1640202 discloses a technique for determining whether or not a malignant lesion by analyzing the spectrum of the light generated from the pigmented lesion and / or the image of the pigmented lesion. All of the technical contents described in Korean Patent Publication No. 10-1640202 (July 11, 2016) are incorporated as part of the present specification.
  • the laser is irradiated twice at different times to the target.
  • the laser irradiated to the target is the first laser
  • the laser irradiated later is the second laser and at the same time the third laser.
  • the laser irradiated to the target is the first laser and the third laser at the same time, and the laser irradiated later is the second laser.
  • the laser irradiated to the target is the second laser
  • the laser irradiated later is the first laser and at the same time the third laser.
  • the laser irradiated to the target first is the second laser and at the same time the third laser, and the laser irradiated later is the first laser.
  • the laser is irradiated three times at different times to the target.
  • the laser irradiated to the target is the first laser
  • the laser irradiated next is the second laser
  • the laser irradiated last is the third laser.
  • the laser irradiated to the target first is the second laser
  • the laser irradiated next is the second laser
  • the laser irradiated last is the second laser
  • the laser irradiated to the target first is the third laser
  • the laser irradiated next is the first laser
  • the laser irradiated last is the second laser.
  • FIG. 6 is a view for explaining a diagnosis system for pigmented lesions according to another embodiment of the present invention.
  • a diagnosis system for pigmented lesions includes a laser generator 1, a light collecting unit 2, a cosmetic or medical laser handpiece 3, and a diagnosis apparatus for pigmented lesions 10. ), And an image comparator 18.
  • the diagnostic apparatus 10 includes a spectroscope 4, an acoustic sensor 5, a diagnostic 7, a pigmented lesion DB storage 11, a laser type DB storage 12, a reference spectrum DB storage for disease diagnosis ( 13), the spectrum data comparison unit 14, the image collecting unit 16, the disease diagnosis reference image DB storage unit 17, and the light detecting unit 19.
  • the diagnosis unit 7 includes a pigmented lesion diagnosis unit 7a and a disease diagnosis unit 7b.
  • the first laser for acquiring the photoacoustic wave, the second laser for acquiring the generated light and the third laser for acquiring the image of the pigmented lesion are the same laser. . Therefore, in the present embodiment described with reference to FIG. 6, the first laser, the second laser, and the third laser will be referred to as 'lasers' without being distinguished.
  • the laser irradiation time information is acquired by the light sensing unit 19 and provided to the pigmented lesion diagnosis unit 7a, and the spectrum of the generated light and the pigmented lesion by the disease diagnosis unit 7b.
  • the embodiment described with reference to Figure 1 determines the type of the disease in consideration of all of the images.
  • FIG. 6 will be described based on differences from the embodiment of FIG. 1.
  • the acoustic sensing unit 5 may detect a photoacoustic wave generated when the laser is irradiated to a target for checking the depth and / or thickness of the pigmented lesion.
  • the pigmented lesion diagnosis unit 7a calculates the depth and / or thickness of the pigmented lesion based on the time at which the photoacoustic wave is detected by the sound sensing unit 5 and the laser irradiation time information, and the laser type and / or progression. The state can be determined.
  • the comparison result of the image comparison unit 18 and the comparison result of the spectral data comparison unit 14 are provided to the disease diagnosis unit 7b, and the disease diagnosis unit 7b reflects the image comparison result and the spectral data comparison result. Determine the type of pigmented lesion.
  • the disease diagnosis unit 7b determines the type of the pigmented lesion by reflecting at least one of the comparison result of the spectral data comparison unit 14 and the comparison result of the image comparison unit 18.
  • the pigmented lesion diagnosis unit 7a may calculate the depth and / or thickness of the pigmented lesion based on the time when the photoacoustic wave is detected by the acoustic detector 5 and the laser detection result by the light detector 19. Can be.
  • the light sensing unit 19 please refer to the description of the embodiment described with reference to FIG.
  • the laser is irradiated twice at different times to the target.
  • the laser irradiated to the target is the first laser
  • the laser irradiated later is the second laser and at the same time the third laser.
  • the laser irradiated to the target is the first laser and the third laser at the same time, and the laser irradiated later is the second laser.
  • the laser irradiated to the target is the second laser
  • the laser irradiated later is the first laser and at the same time the third laser.
  • the laser irradiated to the target first is the second laser and at the same time the third laser, and the laser irradiated later is the first laser.
  • the laser is irradiated three times at different times to the target.
  • the laser irradiated to the target is the first laser
  • the laser irradiated next is the second laser
  • the laser irradiated last is the third laser.
  • the laser irradiated to the target first is the second laser
  • the laser irradiated next is the second laser
  • the laser irradiated last is the second laser
  • the laser irradiated to the target first is the third laser
  • the laser irradiated next is the first laser
  • the laser irradiated last is the second laser.
  • the light detecting unit 19 detects the first laser irradiated to the target or the generated light generated when the first laser is irradiated to the target.
  • FIG. 7 is a view for explaining a method for diagnosing pigmented lesions according to an embodiment of the present invention.
  • a step (S101) of irradiating a laser ('first laser') with a target having a pigmented lesion, the target to which the first laser is irradiated Detecting the photoacoustic wave generated from the step S103 and calculating depth and / or thickness of the pigmented lesion based on the laser irradiation time information and the acoustic detection time at which the photoacoustic wave is detected (S105).
  • Determining the type of pigmented lesion by analyzing the spectrum of the generated light generated when the laser ('second laser') is irradiated to the target (S107), if it is determined that the malignant lesion in step S107 (S109: YES) malignant lesion Determining the progress state (stage) of (S111), if it is determined that the benign lesion in step S107 (S109: NO) selecting the type of laser (S113), and displaying the results of S111 and S113 to the user Contains (S115) do.
  • the method for determining the pigmented lesion described with reference to FIG. 6 may be performed by the embodiments of the diagnosis apparatus for the pigmented lesion described with reference to FIGS. 1, 2, 3, 4, 5, and / or 6. Can be implemented.
  • the pigmented lesion diagnosis unit 9a may calculate the depth of the pigmented lesion using ⁇ Equation 1>, and calculate the depth of the pigmented lesion using ⁇ Equation 2>.
  • the detecting of the photoacoustic wave (S103) may be performed by the sound sensor 5.
  • the step (S103) of detecting the sound may be performed by the sound sensing unit 5 coupled to the handpiece 3 receiving the laser and flowing out to the target.
  • step S107 is configured to determine the type of pigmented lesion by analyzing the spectrum of the generated light (for example, the embodiment of FIGS. 1 and 4), or the pigmented lesion by analyzing the spectrum of the generated light and the image of the pigmented lesion. It may be configured to determine the type of (for example, the embodiment of Figures 5 and 6)
  • the present embodiment may further include a light sensing step of detecting a laser emitted to the target.
  • the detection result of the light sensing step is used when performing the step S105.
  • the light sensing step may be performed by the light detecting unit 19 for detecting a laser irradiated to the target.
  • the embodiment may further include controlling the wavelength, power, and / or pulse length of the laser generating device that generates the laser irradiated onto the target.
  • the controlling may be performed by a controller (not shown) that controls the laser generating device to generate a laser having a wavelength, power, and / or pulse width corresponding to the depth and / or thickness of the pigmented lesion. have.
  • the first laser and the second laser are the same lasers or those irradiated to the target at different times.

Abstract

La présente invention concerne un système de diagnostic de lésions pigmentées, comprenant : une unité de détection acoustique destinée à la détection d'ondes photoacoustiques générées lorsqu'un premier faisceau laser est rayonné sur une cible contenant une lésion pigmentée ; une unité de diagnostic de maladie destinée à la détermination du type de lésion pigmentée sur la base de la lumière générée lorsqu'un second faisceau laser est rayonné sur la cible ; et une unité de diagnostic de lésion pigmentée destinée au calcul d'au moins l'une de la profondeur et de l'épaisseur de la lésion pigmentée, sur la base de l'information sur le temps lorsque les ondes photoacoustiques ont été détectées et de l'information sur le temps d'exposition au rayonnement du premier faisceau laser rayonné sur la cible.
PCT/KR2017/003703 2016-04-04 2017-04-04 Système et procédé de diagnostic de lésions pigmentées WO2017176039A1 (fr)

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US15/540,366 US20180085004A1 (en) 2016-04-04 2017-04-04 System and method for diagnosing pigmented lesion

Applications Claiming Priority (8)

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KR10-2016-0041316 2016-04-04
KR20160041316 2016-04-04
KR20160041993 2016-04-06
KR10-2016-0041993 2016-04-06
KR10-2016-0115675 2016-09-08
KR1020160115675A KR20170114229A (ko) 2016-04-04 2016-09-08 질병 진단과 피부 나이 측정이 가능한 시스템과 이에 사용되는 핸드피스
KR10-2017-0012935 2017-01-26
KR20170012935 2017-01-26

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080154257A1 (en) * 2006-12-22 2008-06-26 Shiva Sharareh Real-time optoacoustic monitoring with electophysiologic catheters
KR20090059667A (ko) * 2007-12-07 2009-06-11 (주) 디바이스이엔지 영상인식 자동 레이저치료기 및 그 제어방법
KR20090097904A (ko) * 2007-01-05 2009-09-16 마이스킨 인크 피부 이미징을 위한 시스템, 디바이스 및 방법
KR20120066286A (ko) * 2010-12-14 2012-06-22 한국전자통신연구원 광선치료 장치 및 방법
JP2013500464A (ja) * 2009-07-24 2013-01-07 ガルデルマ・リサーチ・アンド・デヴェロップメント 皮膚黒色腫の赤外イメージング

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080154257A1 (en) * 2006-12-22 2008-06-26 Shiva Sharareh Real-time optoacoustic monitoring with electophysiologic catheters
KR20090097904A (ko) * 2007-01-05 2009-09-16 마이스킨 인크 피부 이미징을 위한 시스템, 디바이스 및 방법
KR20090059667A (ko) * 2007-12-07 2009-06-11 (주) 디바이스이엔지 영상인식 자동 레이저치료기 및 그 제어방법
JP2013500464A (ja) * 2009-07-24 2013-01-07 ガルデルマ・リサーチ・アンド・デヴェロップメント 皮膚黒色腫の赤外イメージング
KR20120066286A (ko) * 2010-12-14 2012-06-22 한국전자통신연구원 광선치료 장치 및 방법

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