WO2017126805A1 - Scanner à mems utilisant une sonde de type stylo portative photo-acoustique/ultrasonore, et système et procédé d'obtention d'image photo-acoustique utilisant celui-ci - Google Patents

Scanner à mems utilisant une sonde de type stylo portative photo-acoustique/ultrasonore, et système et procédé d'obtention d'image photo-acoustique utilisant celui-ci Download PDF

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Publication number
WO2017126805A1
WO2017126805A1 PCT/KR2016/014336 KR2016014336W WO2017126805A1 WO 2017126805 A1 WO2017126805 A1 WO 2017126805A1 KR 2016014336 W KR2016014336 W KR 2016014336W WO 2017126805 A1 WO2017126805 A1 WO 2017126805A1
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Prior art keywords
photoacoustic
optoacoustic
laser
ultrasonic
type probe
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PCT/KR2016/014336
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English (en)
Korean (ko)
Inventor
김철홍
박경진
김진영
임근배
이창호
Original Assignee
포항공과대학교 산학협력단
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Publication of WO2017126805A1 publication Critical patent/WO2017126805A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings

Definitions

  • the present invention relates to an optoacoustic / ultrasonic handheld pen type probe, and more particularly, to an optoacoustic / ultrasound handheld pen type probe using a MEMS scanner, and a photoacoustic image acquisition system and method using the same.
  • Optoacoustic tomography technology refers to a novel image processing method in which an optical system and an ultrasonic system are combined. That is, when the tissue is irradiated with light, the tissue absorbs light energy, and the tissue absorbed by the light energy undergoes thermal-elastic expansion, and the thermal expansion generates ultrasonic waves. This is called a photoacoustic effect, and the ultrasonic signal generated by thermal expansion is called an optoacoustic signal.
  • a technique of acquiring an image of the inside of the biological tissue by using the photoacoustic signal is called photoacoustic tomography.
  • the photoacoustic tomography apparatus obtains the photoacoustic signal generated through the ultrasonic transducer, and generates the tomographic image information by signal processing the obtained photoacoustic signal.
  • the photoacoustic image obtained in this way has the advantage of non-invasive high-resolution internal biometric image and visual contrast perceived by the eye as it is, and by using it, blood flow velocity and oxygen saturation as well as structural blood vessel information in vivo without special contrast agent are used.
  • Functional information such as can be provided in real time.
  • the photoacoustic tomography-based imaging technology that can provide information inside the living body, it is necessary to use it in the surgical environment.
  • the high resolution is maintained in real time.
  • the ability to acquire an image is essential.
  • Korean Unexamined Patent Publication No. 10-2015-0010909 and Korean Unexamined Patent Publication No. 10-2015-0053630 disclose prior art literature on imaging medical devices using photoacoustic or ultrasonic waves.
  • the present invention has been proposed to solve the above problems of the conventionally proposed methods, but using a MEMS scanner, in order to integrate all the systems into an integrated probe type, the MEMS scanner is also configured in an oblique form, an optical transmission unit, By integrating both the ultrasonic transmitter and the mechanical MEMS scanner into one small tube, the optimum alignment of the structure allows the scanner to be linearly driven, resulting in fast imaging and at the same time the size of the device. To reduce abnormal bleeding and tissue removal, reduce the time required for biopsy, and provide immediate medical judgment to physicians. Photoacoustic / ultrasound using MEMS scanners, which may enable more sophisticated surgery It is an object of the present invention to provide a wave handle pen type probe, and a photoacoustic image acquisition system and method using the same.
  • an optoacoustic / ultrasound handle type pen type probe using a MEMS scanner an optoacoustic / ultrasound handle type pen type probe using a MEMS scanner
  • Ultrasonic transducers capable of transmitting and receiving optoacoustic / ultrasound signals
  • a light transmission unit disposed to be perpendicular to the ultrasonic transducer and transmitting a laser supplied from an external light source;
  • a beam combiner disposed to be in contact with the ultrasonic transducer and the light transmitting part, and passing a laser beam transmitted through the light transmitting part, and reflecting an optoacoustic signal generated from an object toward the ultrasonic transducer;
  • a scanner disposed between the beam combiner and the object to reflect the laser beam passing through the beam combiner in the direction of the object and reflect the photoacoustic signal generated from the object in the direction of the beam combiner. It is characterized by its configuration.
  • the light transmission unit Preferably, the light transmission unit, the light transmission unit, and
  • It may include an objective lens for condensing the parallel light generated through the collimator to the beam coupling unit.
  • the beam coupling portion Preferably, the beam coupling portion,
  • Silicon oil may be applied to the material so that the laser passes and the photoacoustic signal is reflected.
  • the scanner Preferably, the scanner, the scanner, and
  • MEMS Micro Electro Mechanical System
  • a front portion including a reflection mirror reflecting the laser and photoacoustic signals
  • a drive unit for driving the reflective mirror inclined in two axes.
  • a first front member to which the reflective mirror is attached
  • It may include a second front member for receiving the first front member inside.
  • a total of four neodymium (Nd) magnets may be further attached to lower surfaces of both ends of the first front member in the y-axis direction and lower surfaces of both ends of the second front member in the x-axis direction. have.
  • the driving unit Even more preferably, the driving unit,
  • the four Nd magnets may include a total of four electromagnets (Electromagnets) spaced apart from each other to face each other with the four Nd magnets.
  • It may be arranged in a diagonal structure inclined at an angle of 45 degrees.
  • an optoacoustic image acquisition system using an optoacoustic / ultrasonic handle type pen type probe
  • a light source module for supplying any one laser selected from a Q-switch pulse laser, a multi-wavelength conversion die laser, and an OPO laser;
  • An optoacoustic / ultrasound signal acquisition module that receives the laser supplied from the light source module and emits the laser to the object, and detects the photoacoustic signal generated by the object by absorbing the laser;
  • An amplification module for receiving and amplifying the photoacoustic signal detected by the photoacoustic / ultrasound signal acquisition module;
  • a data acquisition module for acquiring image data through image processing using the signal amplified by the amplification module; And a control module connected to the photoacoustic / ultrasound signal acquisition module and the data acquisition module to drive the photoacoustic / ultrasound signal acquisition module.
  • the laser supplied from the light source module may be transmitted to the photoacoustic / ultrasonic signal acquisition module through an optical fiber.
  • the optoacoustic / ultrasonic signal acquisition module Preferably, the optoacoustic / ultrasonic signal acquisition module,
  • It consists of a photoacoustic / ultrasound handheld pen type probe using a MEMS scanner.
  • Ultrasonic transducers capable of transmitting and receiving optoacoustic / ultrasound signals
  • a light transmission unit disposed to be perpendicular to the ultrasonic transducer and transmitting a laser supplied from the light source module;
  • a beam combiner disposed to be in contact with the ultrasonic transducer and the light transmitting part and configured to pass a laser beam transmitted through the light transmitting part and to reflect an optoacoustic signal generated from the object;
  • a scanner disposed between the beam combiner and the object to reflect the laser beam passing through the beam combiner in the direction of the object and reflect the photoacoustic signal generated from the object toward the beam combiner.
  • the scanner More preferably, the scanner,
  • MEMS Micro Electro Mechanical System
  • a front portion including a reflection mirror reflecting the laser and photoacoustic signals
  • a drive unit for driving the reflective mirror inclined in two axes.
  • a first front member to which the reflective mirror is attached
  • a second front member accommodating the first front member inside
  • a total of four neodymium (Nd) magnets may be attached to the lower side surfaces of both ends of the first front member in the y-axis direction and the lower side surfaces of both ends of the second front member in the x-axis direction.
  • the driving unit Even more preferably, the driving unit,
  • the four Nd magnets may include a total of four electromagnets (Electromagnets) spaced apart from each other to face each other with the four Nd magnets.
  • control module Even more preferably, the control module,
  • the electromagnetic force of the electromagnet may be controlled to be connected to the driving unit so that the reflective mirror is inclined in two axes.
  • a light source module supplying a Q-switch pulse laser
  • a photoacoustic / ultrasound acquisition module receiving the laser supplied in the step (1) and emitting it to the object, and detecting the photoacoustic signal generated by the object absorbing the laser;
  • the data acquisition module includes the step of acquiring image data through image processing using the signal amplified in step (3).
  • the photoacoustic / ultrasonic signal acquisition module of the step (2) Preferably, the photoacoustic / ultrasonic signal acquisition module of the step (2),
  • It consists of a photoacoustic / ultrasound handheld pen type probe using a MEMS scanner.
  • Ultrasonic transducers capable of transmitting and receiving optoacoustic / ultrasound signals
  • a light transmission unit disposed to be perpendicular to the ultrasonic transducer and transmitting a laser supplied from the light source module;
  • a beam combiner disposed to be in contact with the ultrasonic transducer and the light transmitting part and configured to pass a laser beam transmitted through the light transmitting part and to reflect an optoacoustic signal generated from the object;
  • a scanner disposed between the beam combiner and the object to reflect the laser beam passing through the beam combiner in the direction of the object and reflect the photoacoustic signal generated from the object toward the beam combiner.
  • the scanner More preferably, the scanner,
  • MEMS Micro Electro Mechanical System
  • a front portion including a reflection mirror reflecting the laser and photoacoustic signals
  • a drive unit for driving the reflective mirror inclined in two axes.
  • a first front member to which the reflective mirror is attached
  • a second front member accommodating the first front member inside
  • a total of four neodymium (Nd) magnets may be attached to the lower side surfaces of both ends of the first front member in the y-axis direction and the lower side surfaces of both ends of the second front member in the x-axis direction.
  • the driving unit Even more preferably, the driving unit,
  • the four Nd magnets may include a total of four electromagnets (Electromagnets) spaced apart from each other to face each other with the four Nd magnets.
  • the MEMS scanner is used to integrate all systems into an integrated probe type.
  • the scanner can also be configured in an oblique form, integrating the light transmitting unit, the ultrasonic transmitting unit and the mechanical MEMS scanner all in one small tube, and at the same time implementing the optimum arrangement of the structure, thereby achieving linear driving of the scanner. This enables faster imaging while reducing the size of the device, enabling real-time diagnosis of abnormal areas of the internal organs and tumor border inspections, reducing unnecessary bleeding and tissue removal, and reducing the time required for biopsy To provide medical staff with immediate medical judgment, This may be drinking.
  • FIG. 1 is a view showing a schematic configuration of an optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • FIG. 2 is a view showing a schematic view of the beam coupling portion of the optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • FIG 3 is a view showing the external structure and internal structure of the scanner of the optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • Figure 4 is a diagram showing a schematic configuration of an optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to another embodiment of the present invention.
  • FIG. 5 is a diagram illustrating a schematic configuration of an optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to another embodiment of the present invention
  • FIG. 6 is a diagram illustrating an optoacoustic image acquisition system using an optoacoustic / ultrasonic handheld pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • FIG. 7 is a diagram illustrating a mechanical diagram of an optoacoustic image acquisition system using an optoacoustic / ultrasonic handheld pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • FIG. 8 is a diagram for describing an optoacoustic image acquired using an optoacoustic image acquisition system using an optoacoustic / ultrasonic handheld pen type probe using a MEMS scanner according to an embodiment of the present invention
  • FIG. 9 is a diagram for describing an optoacoustic image acquired using an optoacoustic image acquisition system using an optoacoustic / ultrasonic handheld pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • FIG. 10 is a flowchart illustrating a method for acquiring an optoacoustic image using an optoacoustic / ultrasound handheld pen type probe using a MEMS scanner according to an embodiment of the present invention.
  • Optoacoustic / Ultrasound acquisition module receives the laser supplied in step S10 and emits to the object, the object to detect the photoacoustic signal generated by absorbing the laser
  • amplifying module receives and amplifies the photoacoustic signal detected in step S20
  • the optoacoustic / ultrasound handle type pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention includes an ultrasonic transducer 110 and a light transmitting unit 130. It may be configured to include a beam coupling unit 150 and a scanner 170.
  • the ultrasonic transducer 110 may exchange photoacoustic / ultrasound signals. That is, the photoacoustic signal, which is an ultrasonic signal generated by thermal expansion, may be detected from the object absorbing the light.
  • the light transmitting unit 130 may be disposed to be perpendicular to the ultrasonic transducer 110 and may transmit a laser supplied from an external light source.
  • the light transmitting unit 130 may include a collimator 131 and an objective lens 133.
  • the collimator 131 may make the laser supplied from the external light source into parallel rays, and the objective lens 133 may focus the parallel rays generated through the collimator 131 on the beam combiner 150.
  • the laser when a laser is transmitted from an external light source, the laser is generated as parallel light through the collimator 131, which may be concentrated on the beam combiner 150 while passing through the objective lens 133. Therefore, the collimator 131, the objective lens 133, and the beam combiner 150 may be horizontally arranged in parallel.
  • the medium for transmitting the laser from the external light source to the light transmission unit 130 may be an optical fiber.
  • the beam coupling unit 150 is disposed to contact the ultrasonic transducer 110 and the light transmitting unit 130, and passes the laser beam transmitted through the light transmitting unit 130, and the photoacoustic signal generated from the object is ultrasonic. It may be reflected in the direction of the transducer 110.
  • the beam coupling unit 150 may be a material to which silicon oil is applied so that the laser passes and the photoacoustic signal is reflected.
  • the beam combiner 150 will be described in detail later with reference to FIG. 2.
  • the scanner 170 is disposed to be positioned between the beam combiner 150 and the object, reflects the laser beam passing through the beam combiner 150 in the direction of the object, and transmits the photoacoustic signal generated from the object to the beam combiner 150. ) Can be reflected in the
  • the optoacoustic / ultrasound handle type pen type probe 100 proposed by the present invention includes a scanner 170, a collimator 131, an objective lens 133, and a beam coupling unit 150. ) And all the optical / ultrasound transmission means including the ultrasonic transducer 110 in one handheld pen type probe 100, which according to the embodiment has a diameter of 17 mm It can be nothing.
  • the beam coupling unit 150 of the optoacoustic / ultrasound handle type pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention has a short length of 11 to 12 mm. It may have a sophisticated structure for fitting the interface of the probe 100 to the acoustic focal length. More specifically, depending on the embodiment, the acoustic focal length may be 11.6 mm.
  • the scanner 170 of the photoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention is a microelectromechanical system (Micro Electro Mechanical). System, MEMS) scanner, and more specifically, may include a front portion 171 and a driver 173.
  • MEMS Micro Electro Mechanical System
  • the front part 171 may include a reflection mirror 171c for reflecting a laser and an optoacoustic signal. That is, the laser beam transmitted through the beam coupling unit 150 and the photoacoustic signal emitted from the object may be reflected by the reflection mirror 171c attached to the front part 171.
  • the front portion 171 may include a first front member 171a to which the reflective mirror 171c is attached and a second front member 171b to accommodate the first front member 171a therein,
  • the first front member 171a may be a rectangular flat plate
  • the second front member 171b may be a groove for accommodating the first front member 171a in the form of a rectangular flat plate. It may be an elliptical flat plate provided.
  • the front part 171 is a total of four attached to the lower side of both ends in the y-axis direction of the first front member 171a and the lower side of both ends in the x-axis direction of the second front member 171b.
  • Four neodymium (Nd) magnets 171d may be further included.
  • the driving unit 173 may be positioned below the front part 171 to drive the reflective mirror 171c to be inclined in two axes. That is, the driving mirror may be provided to allow the reflective mirror 171c attached to the front part 171 to be inclined in two axes in the x-axis direction and the y-axis direction.
  • the driving unit 173 may include a total of four electromagnets 173a positioned on the lower surfaces of the four Nd magnets 171d to be spaced apart from each other to face the four Nd magnets 171d.
  • the first front member 171a may be inclined in the y-axis direction, or the second front member 171b may be inclined in the x-axis direction. The movement can be performed, and thus the direction in which the laser and the optoacoustic signals are reflected can be precisely controlled.
  • the front portion 171 and the driving unit 173 may be arranged in a diagonal structure inclined at an angle of 45 degrees, due to this oblique structural feature the front portion 171 has a long axis and a short axis It may have an elliptical structure.
  • FIG. 4 is a diagram illustrating a schematic configuration of an optoacoustic / ultrasonic handle type pen type probe using a MEMS scanner according to another embodiment of the present invention.
  • the scanner 170, the beam coupling unit 150, and the ultrasonic transducer 110 are disposed below and the handle portion is vertically used, compared to the horizontal type. It can increase the convenience. In addition, it can be easily used in a narrow area by reducing the floor area.
  • FIG. 5 is a diagram illustrating a schematic configuration of an optoacoustic / ultrasound handle type pen type probe 100 using the MEMS scanner 170 according to another embodiment of the present invention.
  • two MEMS scanners 170 may be used, in which the two-axis driving of the reflective mirror 171c of the scanner 170 is performed separately. It can be driven by a scanner. Such individual driving may further improve the linearity of the movement of the scanner 170 and may realize a high signal-to-noise ratio (SNR).
  • SNR signal-to-noise ratio
  • the photoacoustic image acquisition system using the photoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention includes a light source module 10, It may be configured to include an optoacoustic / ultrasonic signal acquisition module 20, the amplification module 30, the data acquisition module 40 and the control module 50.
  • the light source module 10 may supply any one selected from a Q-switch pulse laser, a multi-wavelength conversion die laser, and an OPO laser, and the laser supplied from the light source module 10 may be It may be transmitted to the photoacoustic / ultrasonic signal acquisition module 20 through the optical fiber. In this case, the laser beam delivered to the photoacoustic / ultrasound signal acquisition module 20 may be finally emitted to and absorbed by the object.
  • the light source module 10 supplies a multi-wavelength conversion die laser or an OPO laser instead of a Q-switch pulse laser to obtain functional information such as oxygen saturation and blood flow rate. You may.
  • the photoacoustic / ultrasound signal acquisition module 20 may receive the laser supplied from the light source module 10 and emit the laser to the object, and detect the photoacoustic signal generated by the object absorbing the laser.
  • the photoacoustic / ultrasound signal acquisition module 20 may be configured as a photoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170.
  • the photoacoustic / ultrasound handle type pen type probe 100 using the MEMS scanner 170 includes an ultrasonic transducer 110, a light transmitting unit 130, a beam coupling unit 150, and a scanner 170.
  • the scanner 170 may include a front portion 171 including the reflective mirror 171c and the Nd magnet 171d and a driving unit 173 including the electromagnet 173a.
  • Each specific configuration is as described in detail above with reference to FIGS. 1 to 5, and will be omitted below.
  • the amplification module 30 may receive and amplify the photoacoustic signal detected from the photoacoustic / ultrasound signal acquisition module 20.
  • the amplification module 30 may be configured as a conventional pulser-receiver according to the embodiment.
  • the data acquisition module 40 may obtain image data through image processing using the signal amplified by the amplification module 30. That is, the data acquisition module 40 may finally acquire the internal image of the object.
  • the data acquisition module 40 may generate a synchronization signal for emitting the laser from the light source module 10.
  • the light source module 10 may include the data acquisition module 40.
  • the laser can be supplied in accordance with the synchronization signal generated by.
  • the control module 50 may be connected to the photoacoustic / ultrasound signal acquisition module 20 and the data acquisition module 40 to drive the photoacoustic / ultrasound signal acquisition module 20. More specifically, the control module 50 is connected to the driving unit 173 of the scanner 170 of the photoacoustic / ultrasound handle type pen type probe 100 constituting the photoacoustic / ultrasound signal acquisition module 20.
  • the electromagnetic force of the electromagnet 173a may be controlled such that the reflective mirror 171c is inclined in the biaxial direction.
  • FIG. 7 is a diagram illustrating a mechanical diagram of an optoacoustic image acquisition system using the optoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention.
  • the photoacoustic image acquisition system according to the exemplary embodiment of the present invention uses the photoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170, and the photoacoustic tomography image. Can be obtained in real time.
  • the light source module 10 supplies the laser in accordance with the synchronization signal generated by the data acquisition module 40, and the supplied laser is a handle type that forms the photoacoustic / ultrasound signal acquisition module 20 through the optical fiber. It enters the pen type probe 100.
  • the laser is emitted to the object through the probe 100, the photoacoustic signal generated by the object absorbs the laser is reflected through the scanner 170, at this time, the scanner 170, by the control module 50
  • the drive can be controlled.
  • the photoacoustic signal reflected by the scanner 170 is transmitted to the ultrasonic transducer 110, amplified by the amplification module 30, and transmitted to the data acquisition module 40.
  • the finally delivered photoacoustic signal may be obtained by real-time tomography image after signal processing.
  • FIG. 8 illustrates an optoacoustic image acquired using an optoacoustic image acquisition system using the optoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention.
  • the photoacoustic image range may be adjusted according to an applied voltage.
  • a total of three diagrams sequentially from the left to the right of FIG. 8 show respective image ranges when 2V is applied when 1V is applied when 0.5V is applied, and each obtained image is obtained. It can be seen that the range increases linearly as about 1 ⁇ 1 mm 2, 2 ⁇ 2 mm 2, and 3 ⁇ 3 mm 2.
  • FIG. 9 illustrates an optoacoustic image acquired using an optoacoustic image acquisition system using the optoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention.
  • an optoacoustic / ultrasound handheld pen type probe 100 using the MEMS scanner 170 according to an exemplary embodiment of the present invention may acquire an optoacoustic image at a high speed. .
  • the left diagram of FIG. 9 is an actual photographic image of a mouse, and the right diagram is a result of photographing a range of the image shown on the left as an optoacoustic image.
  • the applied voltage may be x-axis (3V), y-axis (y-axis) 5V, the image range of the x-axis 1.25mm, y-axis 2mm, the energy per unit pulse used is 450nJ / pulse, The frame rate may be 0.125 (f / s), and finally an optoacoustic image may be acquired with only a scan time of 8 seconds.
  • the photoacoustic image acquisition method using the photoacoustic / ultrasonic handheld pen type probe 100 using the MEMS scanner 170 according to an embodiment of the present invention includes a light source module 10.
  • the photoacoustic / ultrasonic acquisition module 20 receives the laser supplied in step S10 and emits to the object, the object absorbs the laser to generate Detecting the photoacoustic signal (S20), the amplifying module 30 receives and amplifies the photoacoustic signal detected in step S20 (S30), and the data acquisition module 40 receives the amplified signal in step S30. It may be implemented, including the step (S40) to obtain the image data through the image processing.

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Abstract

La présente invention concerne un scanner à MEMS utilisant une sonde de type stylo portative photo-acoustique/ultrasonore, et un système et un procédé permettant d'obtenir une image photo-acoustique utilisant celui-ci. La présente invention utilise un scanner à MEMS qui est également conçu sous une forme oblique de façon à intégrer tous les systèmes dans un type de sonde à une pièce unique de sorte qu'une unité de transmission photo, une unité de transmission ultrasonore et un scanner à MEMS mécanique sont tous intégrés dans un petit tube et, parallèlement, un agencement optimal de la structure est mis en œuvre, de sorte à obtenir un entraînement linéaire du scanner. Ainsi, il est possible de mettre en œuvre une fonction d'imagerie rapide et de réduire la taille de l'appareil, permettant ainsi le diagnostic de parties anormales d'organes internes et l'inspection des périphéries des tumeurs en temps réel. Par conséquent, un saignement inutile et les surfaces de prélèvement des tissus peuvent être réduits, le temps nécessaire pour une biopsie peut être raccourci, une décision de traitement médical immédiate peut être prise par le personnel médical, et une chirurgie plus précise peut être réalisée.
PCT/KR2016/014336 2016-01-18 2016-12-07 Scanner à mems utilisant une sonde de type stylo portative photo-acoustique/ultrasonore, et système et procédé d'obtention d'image photo-acoustique utilisant celui-ci WO2017126805A1 (fr)

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KR10-2016-0005913 2016-01-18
KR1020160005913A KR101949404B1 (ko) 2016-01-18 2016-01-18 Mems 스캐너를 이용한 광음향/초음파 손잡이형 펜타입 프로브, 및 이를 이용한 광음향 영상 획득 시스템 및 방법

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KR102235372B1 (ko) 2019-04-04 2021-04-02 재단법인대구경북과학기술원 프로브 및 이를 포함하는 치아 구조 이미징 시스템
KR102301418B1 (ko) 2021-01-07 2021-09-10 부경대학교 산학협력단 고속 스캔 광음향 영상 입력장치 및 그 제어방법
KR102542585B1 (ko) * 2021-05-11 2023-06-12 경북대학교 산학협력단 피부 내 멜라닌 측정용 자유 스캐닝 펜타입 광음향 단층 센싱 시스템
KR20240043557A (ko) 2022-09-27 2024-04-03 국립부경대학교 산학협력단 광음향 영상 및 초음파 영상의 합성 영상 입력장치 및 그 방법

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JP2015062678A (ja) * 2007-10-25 2015-04-09 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 散乱媒体の画像化方法、画像化装置及び画像化システム
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