WO2017156194A1 - Compositions et procédés pour inhiber l'endonucléase de la pa de l'arn polymérase de la grippe - Google Patents
Compositions et procédés pour inhiber l'endonucléase de la pa de l'arn polymérase de la grippe Download PDFInfo
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- WO2017156194A1 WO2017156194A1 PCT/US2017/021457 US2017021457W WO2017156194A1 WO 2017156194 A1 WO2017156194 A1 WO 2017156194A1 US 2017021457 W US2017021457 W US 2017021457W WO 2017156194 A1 WO2017156194 A1 WO 2017156194A1
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- 0 *c1ncc[o]1 Chemical compound *c1ncc[o]1 0.000 description 21
- DWJDAWGXSLELRQ-UHFFFAOYSA-N CCC1=CNC2C=CC=CC12C Chemical compound CCC1=CNC2C=CC=CC12C DWJDAWGXSLELRQ-UHFFFAOYSA-N 0.000 description 1
- QXOAOKTUPHMFTR-UHFFFAOYSA-N CCCc1c[nH]c2ccccc12 Chemical compound CCCc1c[nH]c2ccccc12 QXOAOKTUPHMFTR-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
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- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/717—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a seven- to twelve-membered ring
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- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
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- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
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- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/38—Unsaturated compounds containing keto groups
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- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
L'invention concerne entre autres des inhibiteurs de métalloenzymes, tels que des inhibiteurs de l'endonucléase de la sous-unité PA de l'ARN polymérase ARN-dépendante de la grippe de type A, et des procédés de synthèse et d'utilisation de ceux-ci.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/125,468 US10889556B2 (en) | 2016-03-08 | 2018-09-07 | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662305407P | 2016-03-08 | 2016-03-08 | |
US62/305,407 | 2016-03-08 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US16/125,468 Continuation-In-Part US10889556B2 (en) | 2016-03-08 | 2018-09-07 | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease |
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WO2017156194A1 true WO2017156194A1 (fr) | 2017-09-14 |
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PCT/US2017/021457 WO2017156194A1 (fr) | 2016-03-08 | 2017-03-08 | Compositions et procédés pour inhiber l'endonucléase de la pa de l'arn polymérase de la grippe |
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WO (1) | WO2017156194A1 (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109897007A (zh) * | 2019-02-25 | 2019-06-18 | 天津国际生物医药联合研究院 | 二羟基嘧啶化合物及其应用 |
CN111205252A (zh) * | 2020-02-10 | 2020-05-29 | 杭州科兴生物化工有限公司 | 具有神经氨酸酶抑制作用的sek15类聚酮化合物及其制备方法和应用 |
US10759814B2 (en) | 2016-08-10 | 2020-09-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
WO2020227180A1 (fr) * | 2019-05-03 | 2020-11-12 | Saint Louis University | Inhibiteurs de nucléotidyltransférases à base de tropolone de soufre et d'amide, et leurs utilisations |
US10889556B2 (en) | 2016-03-08 | 2021-01-12 | The Regents Of The University Of California | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease |
EP4045025A4 (fr) * | 2019-10-16 | 2023-11-22 | Kinesid Therapeutics, Inc. | Dérivés de tropolone et leurs tautomères pour la régulation du fer chez les animaux |
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US20050220895A1 (en) * | 2003-12-17 | 2005-10-06 | Bucalo Louis R | Use of gallium to treat inflammatory arthritis |
US20140079666A1 (en) * | 2011-05-05 | 2014-03-20 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
US20150322413A1 (en) * | 2012-11-27 | 2015-11-12 | Saint Louis University | Hbv rnase h purification and enzyme inhibitors |
US9260453B2 (en) * | 2009-03-26 | 2016-02-16 | Shionogi & Co., Ltd. | Method for producing pyrone and pyridone derivatives |
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2017
- 2017-03-08 WO PCT/US2017/021457 patent/WO2017156194A1/fr active Application Filing
Patent Citations (4)
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US20050220895A1 (en) * | 2003-12-17 | 2005-10-06 | Bucalo Louis R | Use of gallium to treat inflammatory arthritis |
US9260453B2 (en) * | 2009-03-26 | 2016-02-16 | Shionogi & Co., Ltd. | Method for producing pyrone and pyridone derivatives |
US20140079666A1 (en) * | 2011-05-05 | 2014-03-20 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
US20150322413A1 (en) * | 2012-11-27 | 2015-11-12 | Saint Louis University | Hbv rnase h purification and enzyme inhibitors |
Non-Patent Citations (2)
Title |
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CORONA ET AL.: "Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6", PLOS ONE, vol. 11, no. 1, 2016, pages 1 - 18, XP055414154 * |
CREDILLE ET AL.: "Fragment-Based Identification of Influenza Endonuclease Inhibitors", J. MED. CHEM., vol. 59, no. 13, 2016, pages 6444 - 6454, XP055414158, Retrieved from the Internet <URL:http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00628> [retrieved on 20170531] * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10889556B2 (en) | 2016-03-08 | 2021-01-12 | The Regents Of The University Of California | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease |
US10759814B2 (en) | 2016-08-10 | 2020-09-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
US11306106B2 (en) | 2016-08-10 | 2022-04-19 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof |
CN109897007A (zh) * | 2019-02-25 | 2019-06-18 | 天津国际生物医药联合研究院 | 二羟基嘧啶化合物及其应用 |
WO2020227180A1 (fr) * | 2019-05-03 | 2020-11-12 | Saint Louis University | Inhibiteurs de nucléotidyltransférases à base de tropolone de soufre et d'amide, et leurs utilisations |
EP4045025A4 (fr) * | 2019-10-16 | 2023-11-22 | Kinesid Therapeutics, Inc. | Dérivés de tropolone et leurs tautomères pour la régulation du fer chez les animaux |
CN111205252A (zh) * | 2020-02-10 | 2020-05-29 | 杭州科兴生物化工有限公司 | 具有神经氨酸酶抑制作用的sek15类聚酮化合物及其制备方法和应用 |
CN111205252B (zh) * | 2020-02-10 | 2021-10-29 | 杭州科兴生物化工有限公司 | 具有神经氨酸酶抑制作用的sek15类聚酮化合物及其制备方法和应用 |
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