WO2017155552A1 - Lentille de contact - Google Patents

Lentille de contact Download PDF

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Publication number
WO2017155552A1
WO2017155552A1 PCT/US2016/022199 US2016022199W WO2017155552A1 WO 2017155552 A1 WO2017155552 A1 WO 2017155552A1 US 2016022199 W US2016022199 W US 2016022199W WO 2017155552 A1 WO2017155552 A1 WO 2017155552A1
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WO
WIPO (PCT)
Prior art keywords
permeability
permeant
film
material film
contact lens
Prior art date
Application number
PCT/US2016/022199
Other languages
English (en)
Inventor
William E. Meyers
Jerome A. Legerton
Jay P. MARSH
Original Assignee
Innovega, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovega, Inc. filed Critical Innovega, Inc.
Priority to EP16893773.8A priority Critical patent/EP3427104A4/fr
Priority to JP2018567561A priority patent/JP6993361B2/ja
Priority to PCT/US2016/022199 priority patent/WO2017155552A1/fr
Priority to CN201680085533.1A priority patent/CN109154724B/zh
Priority to CN202011262244.9A priority patent/CN112255823B/zh
Publication of WO2017155552A1 publication Critical patent/WO2017155552A1/fr
Priority to JP2021199853A priority patent/JP7208345B2/ja

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses

Definitions

  • Field of the invention relates to the general field of optical lenses, and more specifically toward a contact lens constructed to limit the water transmissibility of at least one area of the lens while maintaining at least a minimum oxygen transmissibility.
  • the water transmissibility maximum and oxygen permeability minimum are achieved by a predetermined lens thickness of a single lens material or by the use of two or more material layers.
  • D diffusivity
  • k the solubility
  • the materials of these lenses are generally silicone acrylates or copolymers of silicone acrylates with hydrophiiic monomers thereby creating silicone hydrogels.
  • the former are typically rigid lenses while the latter are soft lenses.
  • These lenses must be offered in thin designs to support corneal health, which can lead to problems with durability, handling and, in the case of hydrogels, dehydration.
  • PDMS polydimethylsiloxane
  • Refractive treatment with the PDMS contact lens for pediatric aphakia is unique due to the need for extreme optical power in the contact lens that requires a thickness profile with a high center thickness. Sticking problems are rarely observed in such applications. Thick lenses are known to promote lens movement due to forceful contact with the lid during blinking.
  • the lenses for pediatric aphakia have regulatory approval for continuous wearing of up to 30 days; hence, there is no need to remove the lenses frequently thereby reducing the likelihood of epithelial detachment.
  • the PDMS contact lens has a high solubility for oxygen and a large diffusivity (rate of internal flux) for oxygen (deriving from the extreme mobility of the silicon atoms in the polymer) and these properties lead to the very high oxygen permeability (Dk).
  • Diffusivity of the permeant is one property.
  • the second property is the solubility of the permeant in the material through which it is permeating. Materials having high values for both of the properties for a particular permeant always have high permeabilities for that permeant. Since PDMS has a very low solubility for water it is often assumed that water might transport through the material at a slow rate. Following this assumption one would conclude shrinkage due to dehydration is not possible and water transport by permeation is minimal. Strategies to minimize water transport were not recognized or reported as a likely approach to solving the "sticking" problem.
  • Holden and Mertz studied the critical oxygen levels to avoid corneal edema and defined them in terms of oxygen transmissibility and equivalent oxygen percentage.
  • the relationship between corneal edema and hydrogel lens oxygen transmissibility was examined for both daily and extended contact lens wear by measuring the corneal swelling response induced by a variety of contact lenses over a 36 hour wearing period.
  • the relationships derived enabled average edema levels that occur with daily and extended wear in a population of normal young adults to be predicted to within ⁇ 1 .0%.
  • the critical lens oxygen transmissibility required to avoid edema for daily and extended contact lens wear were obtained from the derived curves.
  • Holden and Mertz found under daily wear conditions that lenses having an oxygen transmissibility (Dk/t) of at least 24.1 ⁇ 2.7 X 10 '9 (cm 3 0 2 )/(cnT-s ⁇ mniHg) or Barrers/cm, an Equivalent Oxygen Percentage (EOF) of 9.9%, did not induce corneal edema.
  • Dk/t oxygen transmissibility
  • EEF Equivalent Oxygen Percentage
  • the present disclosure addresses the problem through an alternative approach; creating a lens that meets at least the Holden Mertz minimum criteria for oxygen transmissibility while manifesting water transport of no greater than successful commercialized contact lenses.
  • the present invention discloses means for reducing the water transmissibility while maintaining a minimum level of oxygen transmissibility.
  • a first embodiment of the present invention is a lens having a predetermined thickness to reduce the water transmissibility of an ultrahigh permeable lens material to a maximum acceptable level and while maintaining the oxygen transmissibility to a minimum acceptable level.
  • a second embodiment of the present invention is a lens comprising at least two materials where in the coupled materials are configured into a single device to reduce the water transmissibility of the composite lens to a maximum acceptable level while maintaining the oxygen transmissibility to at least a minimum acceptable level.
  • the current disclosure configures the disparate materials in a "sandwich" or layered configuration with the materials in parallel and perpendicular to the axis of the lens, rather than concentric to the axis of the lens as in the above-mentioned composite or hybrid type lens.
  • Prior art also discloses a lens having an anterior rigid layer and a posterior soft layer for the potpose of providing lens comfort when in contact with the eye and while delivering rigid lens optics.
  • a laminate lens does not address the issues of balancing a maximum acceptable water transmissibility while maintaining at least a minimum oxygen transmissibility.
  • Additional art teaches lenses with air cavities, and cavities filled with fluid and gel materials, which do not address the issues of limiting the lens to a maximum water
  • Prior art also discloses the inclusion of components and elements in lenses which do not address the issues of balancing a maximum acceptable water transmissibility while maintaining at least a minimum oxygen transmissibility.
  • the term “including” should be read as meaning “including, without limitation” or the like; the term “example” is used to provide exemplary instances of the item in discussion, not an exhaustive or limiting list thereof; the terms “a” or “an” should be read as meaning “at least one,” “one or more” or the like; and adjectives such as “conventional,” “traditional,” “normal,” “standard,” “known” and terms of similar meaning should not be construed as limiting the item described to a given time period or to an item available as of a given time, but instead should be read to encompass conventional, traditional, normal, or standard technologies that may be available or known now or at any time in the future. Likewise, where this document refers to technologies that would be apparent or known to one of ordinary skill in the art, such
  • a contact lens is made from one or more films, including a composite film.
  • a composite film is a film made up of multiple films, including multiple layers of films.
  • the contact lens is made solely from the composite film, in which case the terms could be used interchangeably.
  • Fig. 1 is a cross-sectional view of a contact lens with a first thickness and a second greater thickness, in accordance with selected embodiments of the current disclosure.
  • Fig. 2 is a cross-sectional view of a contact lens with two layers with varying
  • Fig. 3 is a cross-sectional view of a contact lens with multiple layers with varying permeabilities for oxygen and for water vapor in accordance with selected embodiments of the current disclosure.
  • Fig. 4 is a cross-sectional view of a contact lens with an outer lens material and an inner material layer in accordance with selected embodiments of the current disclosure
  • Fig. 5 is a cross-sectional view of a contact lens with an outer lens material, an inner material layer and an adhesive layer between the layers in accordance with selected
  • Fig. 6 is a cross-sectional view of a contact lens with an outer lens material and inner material layers displaced in regions of the contact lens in accordance with selected embodiments of the current disclosure.
  • Fig. 7 is a chart of variation of composite permeability to oxygen and water as a fraction of those permeabilities originally expressed by a full thickness of only one of the materials prior to inclusion of a second material layer and the change to those original permeabilities by exchanging partial thicknesses of the original material layer by equivalent partial thickness layers of a second material, that second material having different permeabilities for oxygen and water vapor.
  • Fig. 8 is a chart of a first scenario wherein the oxygen permeability ratios (P 01 /P 02 ) are held constant,
  • Fig. 9 is a chart of a second scenario wherein the oxygen permeability ratios (P 01 P 02 ) are held constant.
  • a first embodiment of the present invention comprises a single lens material having an ultrahigh permeability to oxygen and water vapor.
  • a thickness profile for the lens is selected to reduce the water transmi ssibility to at or below a maximum level while keeping the oxygen transmissibility to at or above a minimum level.
  • Fornasiero and coworkers (2005) measured steady state diffusion of water through commercially successful hydrogel and silicone hydrogel lens materials while Rofojo (1980) measured water transport through silicone rubber lens materials. While the metrics for the two studies were reported to be different, a conversion is possible to put the water permeability into a common metric.
  • the lens thickness profiles of two of the commercially successful lenses are known.
  • a resultant water transmissibility is calculated as the water permeability divided by the thickness. It is noteworthy that the water permeability varies with the humidity surrounding the material as it is measured. Further, the permeability may vary as the hydrogel materials dehydrate and become thinner. Even so, a mean value for a range of ambient humidity can be used for the purpose of the present disclosure.
  • Water permeability can be reported as equal to g / ⁇ cm 2 s-1 or equal to cm/ ⁇ and can be converted to cm 3 /p,g ! ⁇ ⁇ ⁇ ( ) and mmHG/Atm which in turn can be converted to Barrers.
  • Such a conversion allows the conventional hydrogel and silicone hydrogel measured values for water permeability to be compared to the reported values for water permeability of silicone rubber materials.
  • the following table presents the values reported for comparison:
  • Historical reports of lens thickness for polymacon include commercialized lenses ranging from center thickness values from 0.04 to 0.18 mm. The majority of lenses have center thickness values between 0.08 and 0.12 mm or an average of 0.10 mm. Lenses made of polymacon have demonstrated sustained use for more than 50 years with no reports of lens adherence. The study of the long term commercial success of polymacon lenses and the absence of reports of lens adherence or "sticking" suggests that the water vapor transmissibility i s sufficiently low to prevent depletion of the post lens tear layer. It is noteworthy that polymacon constitutes a small percentage of new fits because it also has a low oxygen permeability and falls below the Holden Mertz criteria for oxygen delivery for open eye wearing.
  • the disclosure herein provides for the use of a pre-determined lens thickness as one embodiment for reducing the water transmissibility to an approximate level demonstrated by polymacon lenses while maintaining an oxygen transmissibility at or above the Holden Mertz criteria for open eye wearing.
  • the Holden Mertz value set as the minimum oxygen
  • transmissibility (Dk/t) for lenses of the present invention is 24.1 ⁇ 2.7 X 1() "9 (era 3 (>2)/(cm 2 -s ⁇ mmHg).
  • polydim ethyl siioxane has a reported
  • Dk 340 X 10 "u (cm ' /sec) (niL 0 2 )/ (raL X mm Hg). It is possible for other variants of the same material to have higher or lower measured values of Dk.
  • the present invention is directed to minimizing the thickness to achieve a water transmissibility substantially equivalent to polymacon.
  • a harmonic thickness value for polymacon lenses of 0.08 mm is selected to create the limiting maximum water transmissibility for the present invention.
  • the water transmissibility of polymacon at 50% humidity converted to permeability in Barrers is 11 , 110.
  • the harmonic thickness of the lens is 0.008 cm
  • the water transmissibility (B/t) of the lens example is found to be 13,887.5.
  • the reported permeability value of a variant of polydimethylsiloxane is found to be 40,000 Barrers.
  • the contact lens has an average thickness of greater than 0.4 mm.
  • the contact lens has an average thickness of greater than 0.3 mm.
  • the contact lens has an average thickness of greater than 0.2 mm.
  • a particular embodiment of the current disclosure provides for a lens having the predetermined thickness of the lens area over the majority of the corneal surface regardless of the lens power. This differs from the predicate lenses made of polydimethyisiioxane which have only a high thickness at the geometric center of the lens and which rapidly thin due to the convex curvature of the front surfaces being shorter in radius than the concave curvature of the back surfaces of the lenses and for the purpose of producing high plus dioptric powers to correct aphakia.
  • an alternate embodiment of the present invention is a lens comprised of at least two separate layers deployed such that the more biocompatible layers would be the elements in contact with the anterior and posterior tear films. Elements possessing less desirable mechanical properties or oxygen permeabilities would be deployed in thin layers.
  • the relative thickness of the individual layers within the sandwich would be imposed in relation to the oxygen permeability and water permeability of the individual materials.
  • the determining factors for the relative thickness would be their summed permeabilities for oxygen and their summed permeabilities for water vapor, while attempting to keep the maximum oxygen permeability and the minimum water vapor permeability. It is important to note that it is not the arithmetic sum of the permeabilities; rather, their appropriately summed properties with recognition that the summed properties actually represent the resistance to permeation as opposed to the quantity of transmission allowed.
  • the appropriate mathematical expression is:
  • P is the permeability to a specified permeant of the composite and E- the thickness of the i th layer
  • Pi the permeability of the i th layer to the same permeant and E t the total thickness of the composite in mm.
  • the permeabilities must be expressed in the same units preferably derived by similar methods.
  • a new permeability can be derived for the composite for each of the permeants of interest.
  • a contact lens of the present disclosure may require that oxygen delivery is more important to the cornea while oxygen deprivation might be less problematic beyond the corneal borders where some oxygen is supplied by the underlying vasculature. Conversely water loss from the tear pool beneath the lens is equally negatively
  • peripheral area for water loss is by nature larger than the central area of the lens. If the peripheral area possessed a thicker sandwiched layer resistant to water transport despite a concomitant loss of oxygen transport, the overall loss of the tear pool could be substantially impacted while the diminishment of oxygen availability would be mitigated by the lesser need for oxygen and availability of alternate sources under the periphery of the lens.
  • composition and thicknesses for the layers of the sandwich is most conveniently performed using derivatives of the mathematical expression given above.
  • the two materials had differing ratios of the permeability for oxygen and water such that while in one material the ratio water permeability highly favored the transmission of water over oxygen and in the second material the permeability for water was greatly reduced relative to that of oxygen.
  • the objective is to create a composite sandwich of the two materials wherein the transmission of water is substantially reduced relative to the oxygen permeability and that the overall result is a reduced residual level of oxygen transport that remains within the level acceptable for the intended lens wearing schedule, while the water permeability of the composite is reduced from
  • PQ I is the oxygen permeability of the Polydimethylsiloxane
  • Po?. is the oxygen permeability of the Amorphous Teflon
  • P W1 is the water vapor permeability of Polydimethylsiloxane
  • P ⁇ v2 is the water vapor permeability of
  • Amorphous Teflon Given these values a composite can maintain greater than 80 % of the oxygen permeability of pure PDMS while reducing the water permeation rate to little more than 10% of the permeability of pure PDMS.
  • Fig. 7 is a chart of variation of composite permeability to oxygen and water. While the absolute values of the fractions as expressed in the chart at the end points are controlled by the absolute permeability values of the two components, another very important feature of these values is exposed in this chart. This feature is the asymmetry of the two functions. While the oxygen permeability regresses relatively linearly from its high point when none of the second component is present to its low point when only the second component is present, the water permeability function behaves quite differently. The water permeability of the composite compared to the water permeability of the first component drops precipitously at first inclusion of even very thin layers of the second component.
  • the aspects of the permeabilities employed in this composite that are most responsible for this preferred asymmetry in the result is the disparity in the ratios of the water permeability in the first material relative to that of the second (P wl /P w2 ) compared to the oxygen permeability in the first material relative to that of the second (PO J PQ?.). The greater this disparity the greater the asymmetry.
  • Fig. 8 shows a chart of a first scenario wherein the oxygen permeability ratios (P 01 /P 02 ) are held constant, but the ratio of water permeability ratios (P w i/P w2 ) is larger than that in Fig. 7.
  • Fig. 9 shows a chart of a second scenario wherein the oxygen permeability ratios (Poi''Po 2 ) are held constant, but the ratio of water permeability ratios (P wl P w2 ) is less than that of Fig. 7.
  • the medium, or second component or material, within the first material has a water permeability of less than 10,000 Barrers and an oxygen permeability of greater than 200 Barrers.
  • Another embodiment provides for an area of the composite film m easuring greater than fifty square millimeters of the contact lens that has a thickness of the medium providing a water transmissibility below a maximum value, such as 13887.5 Barrers/cm, while providing an oxygen transmissibility above a minimum value, such as 24.1 x 10 "9 (cm x ml 0 2 )/(sec x ml x mmHg).
  • a permeant ratio for a particular permeant is calculated by taking the ratio of permeability for a permeant of a first material (e.g. P 01 ) to the (or over the) permeability for a permeant for a second material (e.g. P 02 ).
  • the contact lens has different ratios of permeability for two permeants.
  • the composition of the two different layered materials can be chosen to make a second permeant ratio larger than the first permeant ratio.
  • the contact lens can have a first permeant ratio for the permeant oxygen that is smaller than a second permeant ratio for the permeant water (or water vapor).
  • compositions of the layered materials are chosen such that first permeant ratio is 5 or smaller and the second permeant ratio is 10 or larger. In another embodiment, the first permeant ratio is 3 or smaller and the second permeant ratio is 20 or larger. In yet another embodiment, the first permeant ratio is 2 or smaller, and the second permeant ratio is 30 or larger.
  • the differences between the permeability of a permeant of the composite contact lens and a layered material relative to that layered material can be expressed as a percent difference.
  • the composition of the medium and layer thicknesses of the medium may be chosen such that the permeability for a first permeant, such as oxygen, of the composite contact lens is no less than twenty percent of the permeability for the first permanent of the primary material, such as cross-linked polydimethylsiloxane.
  • the permeability for the first permeant of the composite film is no less than fifty percent of the permeability for the first permanent of the primary material.
  • the permeability for the first permeant of the composite film is no less than seventy-five percent of the permeability for the first permanent of the primary material. In yet another embodiment the permeability for the first permeant of the composite fi lm is no less than ninety percent of the permeability for the first permanent of the primary material. In yet another embodiment the permeabil ity for the fi rst permeant of the composite film is no less than ninety-fi ve percent of the permeability for the first permanent of the primary material.
  • Another embodiment has a permeability for the second permanent, such as water or water vapor, of the composite film which is no more than ninety-five percent of the permeability for the second permanent of the primary material, such as cross-linked polydimethylsiloxane.
  • the permeability for the second permeant of the composite film is no more than ninety percent of the permeability for the second permanent of the primary material.
  • the permeability for the second permeant of the composite film is no more than seventy-five percent of the permeability for the second permanent of the primary material.
  • the permeability for the second permeant of the composite film is no more than fifty percent of the permeability for the second permanent of the primary material.
  • the permeability for the second permeant of the composite film is no more than twenty-five percent of the permeability for the second permanent of the primary material. In a further embodiment, the permeability for the second permeant of the composite film is no more than ten percent of the permeability for the second permanent of the primary material.
  • Fig. 1 it depicts a contact lens 100 in accordance with selected embodiments of the current disclosure.
  • the contact lens 100 has a first thickness 101
  • the first lens thickness 101 is a primary material film
  • the additional lens thickness 103 is the same primary material film where the primary material film is made at least in part from polymer containing cross-linked poly dimethyl si loxane or an alternate material having a Dk equal to or greater than 200 Barrers.
  • particular embodiments of the current disclosure may have an additional thickness 103 that is not limited to a location at the anterior surface, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 100.
  • the additional thickness may be employed symmetrically or asymmetrically, or a regional placement may be employed.
  • the lens can be customized for the inclusion of a number and variety of thickness profiles to provide the desired oxygen and water transmissibilities of the finished contact lens 100.
  • the first thickness 101 and the additional lens thickness 103 can be one contiguous element, or two distinct layers with encapsulated components each with a surface contacting the other.
  • Fig. 2 depicts a contact lens 200 in accordance with selected embodiments of the current disclosure.
  • the contact lens 200 has a first material film 201 bounded by a first material interface 202, and a second material film 203 bounded by an anterior surface 204, for the purpose of reducing the water transmissibility of the finished lens to the limitations of the present disclosure.
  • the first material film 201 is a primary material film
  • the additional lens thickness 203 is a layered secondary material film, where at least one of the layered primary material film or layered secondary material film are made at least in part from polymer containing cross-linked polydimethylsiloxane or an alternate material having a Dk equal to or greater than 200 Barrers.
  • particular embodiments of the current disclosure may have a secondary material film 203 that is not limited to a location at the anterior surface, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 200.
  • the secondary material film may be employed posterior or anterior to the primary material film.
  • the lens can be customized for the inclusion of a number and variety of thickness profiles of the primary and secondary material films to provide the desired oxygen and water transmissibilities of the finished contact lens 200.
  • the first thickness 201 and the additional lens thickness 203 can be one contiguous element, or two distinct layers with encapsulated components each with a surface contacting the other.
  • Fig. 3 depicts a cross section of a segment of contact lens 300 in accordance with selected embodiments of the current disclosure.
  • the multi-layered contact lens 300 has an anterior layer 301 , a posterior layer 302, a first internal layer 303, a second internal layer 304 and a third internal layer 305.
  • the contact lens 300 demonstrates relevant water transmissibility in the direction of the arrow 306, which is from the environment posterior to the posterior layer 302 and toward the environment anterior to the anterior layer 301.
  • the contact lens 300 demonstrates relevant oxygen transmissibility in the direction of the arrow 307, which is from the environment anterior to the anterior layer 301, and toward the environment posterior to the posterior layer 302.
  • particular embodiments of the current disclosure may have layers that are not limited in number, to regional locations within or at the apparent relative depths in the lens 300, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 300.
  • fewer or additional layers or a deeper or shallower placement of a layer may be employed, or a regional placement may be employed.
  • the lens can be customized for the inclusion of a number and variety of layers and the thickness of the layers can be determined to provide desired oxygen and water transmissibilities.
  • Fig. 4 depicts a cross section of a layered contact lens 400 in accordance with selected embodiments of the current disclosure.
  • the layered contact lens 400 has first material 401 , and a second material layer 402.
  • the second material layer 402 of the contact lens 400 has a variable thickness profile and is placed in a region of the contact lens 400.
  • the first material 401 is a layered primary material film
  • the second material layer 402 is a layered secondary material film.
  • the layered primary material film is made at least in part from polymer containing silicone acryiate.
  • the layered primary material film is made at least in part from polymer containing cross-linked polydimethylsiloxane or an alternate material having a Dk of equal to or greater than 200 Barrers.
  • the layered secondary material film is made from films having water permeability less than 10,000 Barrers, such as amorphous or crystalline fluorocarbon containing films.
  • the layered secondary material film is made from poiyurethane containing films having water permeability less than 10,000 Barrers.
  • the layered secondary material film is made at least from silicone containing films having water permeability at least less than 10,000 Barrers.
  • the second material 402 is thicker at its center and thinner at its peripheral edges.
  • the contact lens 400 includes a posterior layer of the first material 401 which is posterior to the second material layer 402 and which has a uniform thickness. Further, the contact lens 400 includes an anterior layer of the first material 401, which is anterior to the second material 402 and is thinner at its center and is thicker in the mid periphery of the anterior layer.
  • the layers are not limited in number, to their locations at the apparent thicknesses within the contact lens 400, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 400.
  • the lens can be customized for the inclusion of a number and variety of layers and the thickness of the layers can be determined to provide desired oxygen and water transmissibiiities.
  • Fig. 5 depicts a cross section of a layered contact lens 500 in accordance with selected embodiments of the current disclosure.
  • the layered contact lens 500 has first material 501 , a second material layer 502, and an adhesive layer 503.
  • the second material layer contact iens 502 has a variable thickness profile and is placed in a region of the contact lens 500.
  • the second material 502 is thicker at its center and thinner at its peripheral edges.
  • the contact iens 500 includes a posterior layer of the first material 501 which is posterior to the second material layer 502 and which has a uniform thickness.
  • the contact lens 500 includes an anterior layer of the first material 501, which is anterior to the second material 502 and is thinner at its center and is thicker in the mid periphery of the anterior layer.
  • the adhesive layer 503 surrounds the second material layer 502. In an alternative embodiment, the adhesive layer 503 may not surround a second layer and may be applied to only one partial surface of region of a layer,
  • the layers may not limited in number, to their locations at the apparent thicknesses within the contact lens 500, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 500.
  • additional layers or a deeper or shallower placement of the layers may be employed, or a regional placement may be employed.
  • the lens can be customized for the inclusion of a number and variety of layers and the thickness of the layers can be determined to provide desired oxygen and water transmissibilities.
  • Fig. 6 depicts a cross section of a layered contact lens 600 in accordance with selected embodiments of the current disclosure.
  • the layered contact lens 600 has first material 601, a second material layer 602 and a third material 603 peripheral to the second material 602.
  • the second material 602 has a relatively uniform thickness profile and is placed in the central region of the contact lens 600.
  • Layer 602 may alternatively have the same composition as layer 601.
  • the third material 603 has a variable thickness and is placed in the mid-peripheral region of contact lens 600.
  • the second material 602 is relatively uniform in its thickness.
  • the third material 603 is thicker at its center and thinner at its peripheral edges.
  • the contact lens 600 includes a posterior layer of the first material 601, which has a relatively uniform thickness and which is posterior to the second material layer 602 and the third material 603. Further, the contact lens 600 includes an anterior layer of the first material 601, which is thinner at its center, thicker in the mid periphery of the anteri or layer, and anterior to the second material 602 and the third material 603.
  • particular embodiments of the current disclosure provide layers that are not limited in number, to their locations at the apparent thicknesses within the contact lens 600, to a symmetrical configuration, to a uniform thickness profile, or to a centered position relative to the geometric center of the contact lens 600, For example, additional layers or a deeper or shallower placement of the layers may be employed, or a regional placement may be employed. In this manner, the lens can be customized for the inclusion of a number and variety of layers and the thickness of the layers can be determined to provide desired oxygen and water transmissibiiities.
  • the contact lens may be fabricated at least in part by molding, including cast molding and compression molding. Melt pressing and solution casting may also be implemented, at least in part, to fabricate the contact lens. Additionally, the contact lens may be fabricated at least in part by lathing.
  • the different materials making up the material films, composite films, and/or contact lens can have different moduli.
  • Modulus, or more specifically an elastic modulus, of a material is a measure of the material 's resistance to being deformed elastically.
  • the modulus of the primary material films is greater than the modulus of the secondary material films.
  • the modulus of the primary material films is less than the modulus of the secondary material films.
  • the contact lens may also have a minimum transmissibility of a permeant such as carbon dioxide.
  • a permeant such as carbon dioxide
  • the layers of material film and/or thickness of the contact lens are set for a minimum carbon dioxide transmissibility, instead of or in addition to the minimum oxygen transmissibility.
  • a therapeutic agent deliver ⁇ ' device comprises a composite film, where the composite film comprises one or more layered primary material films and one or more layered secondary material films, where the composite film has a thickness, a permeability for a first permeant, and a permeability for a second permeant; where the primary material films and secondary material film each have a thickness, a permeability for a first permeant, and a permeability for a second permeant; where the thickness of the composite comprises the summed thicknesses of the primary material layers and secondary material layers, where the thickness of the primary films and the thickness of the secondary films are such that the difference between the permeability for the first permeant of the composite film and the permeability for the first permeant of the primary material films is less than the difference between the permeability for the second permeant of the composite film and the permeability of the second permeant the primary material films.
  • the second permeant comprises the composite film, where the composite film comprises one or more layered primary material films and one or more

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  • Ophthalmology & Optometry (AREA)
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  • Laminated Bodies (AREA)

Abstract

La présente invention concerne une lentille de contact construite de manière à limiter la transmissibilité de l'eau d'au moins une zone de la lentille, tout en conservant au moins une transmissibilité d'oxygène minimale. Le minimum de transmissibilité de l'eau et le minimum de perméabilité à l'oxygène sont obtenus grâce à une épaisseur de lentille prédéterminée d'un unique matériau de lentille ou par l'utilisation d'au moins deux couches de matériau.
PCT/US2016/022199 2016-03-11 2016-03-11 Lentille de contact WO2017155552A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP16893773.8A EP3427104A4 (fr) 2016-03-11 2016-03-11 Lentille de contact
JP2018567561A JP6993361B2 (ja) 2016-03-11 2016-03-11 コンタクトレンズ
PCT/US2016/022199 WO2017155552A1 (fr) 2016-03-11 2016-03-11 Lentille de contact
CN201680085533.1A CN109154724B (zh) 2016-03-11 2016-03-11 接触镜
CN202011262244.9A CN112255823B (zh) 2016-03-11 2016-03-11 接触镜
JP2021199853A JP7208345B2 (ja) 2016-03-11 2021-12-09 コンタクトレンズ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/022199 WO2017155552A1 (fr) 2016-03-11 2016-03-11 Lentille de contact

Publications (1)

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WO2017155552A1 true WO2017155552A1 (fr) 2017-09-14

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PCT/US2016/022199 WO2017155552A1 (fr) 2016-03-11 2016-03-11 Lentille de contact

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EP (1) EP3427104A4 (fr)
JP (1) JP6993361B2 (fr)
CN (2) CN109154724B (fr)
WO (1) WO2017155552A1 (fr)

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US20060012751A1 (en) * 1999-12-10 2006-01-19 Rosenzweig Howard S Contact lens
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US20140125944A1 (en) 2012-11-02 2014-05-08 Largan Precision Co., Ltd. Hybrid contact lens, method of producing the same, and mold set for producing the same
US20150137397A1 (en) * 2012-06-19 2015-05-21 Menicon Nect Co., Ltd. Multilayer contact lens and production process therefor

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WO2008055085A1 (fr) * 2006-10-30 2008-05-08 Novartis Ag Procédé pour appliquer un revêtement sur une lentille d'hydrogel de silicone
US8480227B2 (en) * 2010-07-30 2013-07-09 Novartis Ag Silicone hydrogel lenses with water-rich surfaces
WO2014123956A1 (fr) * 2013-02-06 2014-08-14 Momentive Performance Materials Inc. Trisiloxane contenant un (méth)acryloxy, polymères contenant un siloxane et dispositifs biomédicaux les contenant
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US4099859A (en) * 1974-12-02 1978-07-11 High Voltage Engineering Corporation Contact lens having a smooth surface layer of a hydrophilic polymer
US5760100A (en) * 1994-09-06 1998-06-02 Ciba Vision Corporation Extended wear ophthalmic lens
US5760100B1 (en) * 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
US20060012751A1 (en) * 1999-12-10 2006-01-19 Rosenzweig Howard S Contact lens
US20030008154A1 (en) * 2001-05-30 2003-01-09 Celeste Aguado Polymeric materials for making contact lenses
US20070291224A1 (en) * 2006-06-15 2007-12-20 Lai Shui T High Visual Acuity Contact Lenses
US20150137397A1 (en) * 2012-06-19 2015-05-21 Menicon Nect Co., Ltd. Multilayer contact lens and production process therefor
US20140125944A1 (en) 2012-11-02 2014-05-08 Largan Precision Co., Ltd. Hybrid contact lens, method of producing the same, and mold set for producing the same

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Title
See also references of EP3427104A4

Also Published As

Publication number Publication date
CN112255823B (zh) 2022-09-27
EP3427104A4 (fr) 2019-11-20
EP3427104A1 (fr) 2019-01-16
CN109154724B (zh) 2020-12-25
JP6993361B2 (ja) 2022-02-03
JP2019515357A (ja) 2019-06-06
CN109154724A (zh) 2019-01-04
CN112255823A (zh) 2021-01-22

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