WO2017153565A1

WO2017153565A1 - Stabilization of enzymes in cleaning agents containing surfactants

Info

Publication number: WO2017153565A1
Application number: PCT/EP2017/055649
Authority: WO
Inventors: Detlef Buisker; Marianne Schmeling; Johannes Zipfel
Original assignee: Henkel Ag & Co. Kgaa
Priority date: 2016-03-11
Filing date: 2017-03-10
Publication date: 2017-09-14
Also published as: DE102016204063A1

Abstract

The invention relates to the use of a particular surfactant mixture for stabilizing enzymes in a cleaning agent as defined herein, said surfactant mixture comprising at least one betaine and at least one fatty alcohol polyglycol sulfate. The invention further relates to a cleaning agent containing a surfactant mixture as defined herein and at least one enzyme as well as to the corresponding use and methods for using said cleaning agent.

Description

Stabilization of enzymes in surfactant-containing detergents

The present invention relates to the use of a specific surfactant mixture for stabilizing enzymes in a detergent as defined herein. Moreover, the present invention also relates to a detergent containing at least one surfactant mixture as defined herein and at least one enzyme.

The use of enzymes in detergents has been established in the art for decades. They serve to extend the range of services of the funds concerned according to their specific activities. These include in particular hydrolytic enzymes such as proteases, amylases, lipases and cellulases. The first three hydrolyze proteins, starches and fats and thus contribute directly to soil removal. Cellulases are used in particular because of their tissue effect. Another group of detergent and cleaning agent enzymes are oxidative enzymes, in particular oxidases, which, where appropriate, in combination with other components, are preferably used to bleach soiling or to produce the bleaching agents in situ. In addition to these enzymes, which are subjected to constant optimization, further enzymes are constantly being made available for use in detergents and cleaners in order to be able to optimally address particular soiling, such as pectinases, β-glucanases, mannanases or other hemicellulases (glycosidases) Hydrolysis in particular of special vegetable polymers.

The enzymes that are the longest-established and contained in virtually all modern, high-performance detergents are proteases, and in particular serine proteases. They serve the degradation of protein-containing stains on the cleaning material.

In the presence of surfactants proteases are, however, very unstable, whereby the cleaning power of the cleaning agent is reduced overall, especially in aqueous, liquid agents at high surfactant levels.

The object of the present invention was therefore to identify surfactant combinations by means of which enzymes, in particular proteases, in detergents, in particular hand dishwashing detergents, can be stabilized.

This object underlying the present application is now achieved by adding cleaning agents containing at least one protease to stabilize the protease a surfactant mixture comprising at least one betaine and at least one ether sulfate. In a first aspect, therefore, the present invention is directed to the use of a surfactant mixture comprising:

(i) at least one betaine, preferably in an amount of from 0.9 to 15.0% by weight, more preferably from 1.5 to 12.0% by weight, based on the total weight of the composition; and

(ii) at least one ether sulfate, preferably in an amount of from 3.0 to 30.0% by weight, more preferably from 4.0 to 25.0% by weight, based on the total weight of the composition;

for stabilizing enzymes, preferably a protease, in a cleaning agent, preferably dishwashing detergent, more preferably hand dishwashing detergent containing at least one enzyme, preferably at least one protease.

In a further aspect, the present invention is directed to a cleaning agent, preferably dishwashing detergent, more preferably hand dishwashing detergent containing at least one enzyme, preferably a protease, and a surfactant mixture, the surfactant mixture comprising:

(Ii) at least one ether sulfate, preferably in an amount of 3.0 to 30.0 wt .-%, more preferably 4.0 to 25.0 wt .-% based on the total weight of the composition.

In yet another aspect, the present invention is further directed to the use of a detergent as herein described, preferably dishwashing detergent, more preferably hand dishwashing detergent, for cleaning solid surfaces, and to a process for cleaning hard surfaces, characterized in that in at least one process step a detergent as described herein, preferably dishwashing detergent, more preferably hand dishwashing detergent, is used.

"At least one" as used herein includes, but is not limited to, 1, 2, 3, 4, 5, 6 and more.

All percentages given in connection with the compositions described herein, unless explicitly stated otherwise, relate to% by weight, in each case based on the mixture in question.

In the context of the present invention are fatty acids or fatty alcohols or their derivatives - unless otherwise stated - representative of branched or unbranched carboxylic acids or alcohols or their derivatives having preferably 6 to 22 carbon atoms. In particular, the oxo alcohols or their derivatives, which are obtainable, for example, by the RoELEN's oxo synthesis, can also be used correspondingly. Whenever alkaline earth metals are referred to below as counterions for monovalent anions, this means that the alkaline earth metal is present only in half - as sufficient to charge balance - amount of substance as the anion.

According to the invention, a cleaning agent is to be understood as meaning all agents which are suitable for cleaning solid surfaces, for example dishwashing agents, in particular hand dishwashing detergents. Other suitable ingredients will be described in detail below.

These and other aspects, features, and advantages of the invention will become apparent to those skilled in the art from a study of the following detailed description and claims. Any feature of one aspect of the invention may be employed in any other aspect of the invention. Further, it is to be understood that the examples contained herein are intended to describe and illustrate the invention, but not to limit it, and in particular that the invention is not limited to these examples. All percentages are by weight unless otherwise specified, based on the total weight of the composition. Numeric ranges specified in the format "from x to y" include the above values.If multiple preferred numeric ranges are specified in this format, it is understood that all ranges resulting from the combination of the various endpoints, also be recorded.

The cleaning agent according to the invention contains at least one enzyme, preferably a protease. The proteases used are preferably alkaline serine proteases. They act as nonspecific endopeptidases, that is, they hydrolyze any acid amide linkages that are located inside peptides or proteins and thereby cause degradation of proteinaceous soils on the items to be cleaned. Their pH optimum is usually in the clearly alkaline range.

The proteases preferably used according to the invention are preferably a serine protease, in particular a subtilase, more preferably a subtilisin. The subtilisin may be a wild-type enzyme or a subtilisin variant, wherein the wild-type enzyme or the starting enzyme of the variant is preferably selected from one of the following:

the alkaline protease from Bacillus amyloliquefaciens (ΒΡΝ '),

the alkaline protease from Bacillus licheniformis (subtilisin Carlsberg),

the alkaline protease PB92,

Subtilisin 147 and / or 309 (Savinase)

the alkaline protease from Bacillus lentus, preferably from Bacillus lentus (DSM 5483),

the alkaline protease from Bacillus alcalophilus (DSM 1 1233),

the alkaline protease from Bacillus gibsonii (DSM 14391) or an at least 70% identical alkaline protease, the alkaline protease from Bacillus sp. (DSM 14390) or an at least 98.5% identical alkaline protease, and

the alkaline protease from Bacillus sp. (DSM 14392) or an at least 98, 1% identical alkaline protease.

Examples of the proteases used in the agents described herein are subtilisin 309 or functional fragments / variants thereof and variants of the Bacillus lentus alkaline protease or variants thereof. Subtilisin 309 is sold under the trade name Savinase® by Novozymes A / S, Bagsvaerd, Denmark. Of the subtilisin 309 from Bacillus lentus, optimized enzyme variants are available under the trade names Blaze® and Ovozyme® from Novozymes, which represent a preferred embodiment of the invention. From the alkaline protease from Bacillus lentus DSM 5483, for example, derived under the name BLAP® protease variants are derived, preferred are in particular those protease variants that compared to the BLAP wt (wild-type) enzyme, in the count according to BLAP wt have at least one mutation of R99, in particular R99E or R99D, particularly preferably R99E, and optionally additionally at least one or two, preferably all three of the amino acid substitutions S3T, V4I and V199I, particularly preferred are the BLAP variants, as described in SeqlD No 4 or 5 of WO2014 / 177430 are described.

In the cleaning agents described herein, the enzymes to be used may also be formulated together with accompanying substances, for example from the fermentation. In liquid formulations, the enzymes are preferably used as enzyme liquid formulation (s).

The proteases are generally not provided in the form of the pure protein, but rather in the form of stabilized, storable and transportable preparations. Such prefabricated preparations include, for example, the solid preparations obtained by granulation, extrusion or lyophilization or, especially in the case of liquid or gel-form detergents, solutions of the enzymes, advantageously as concentrated as possible, low in water and / or added with stabilizers or further auxiliaries.

Alternatively, the enzymes may be encapsulated for both the solid and liquid dosage forms, for example by spray-drying or extruding the enzyme solution together with a preferably natural polymer or in the form of capsules, for example those in which the enzymes are entrapped as in a solidified gel or in those of the core-shell type, in which an enzyme-containing core is coated with a water, air and / or chemical impermeable protective layer. In deposited layers, further active ingredients, for example stabilizers, emulsifiers, pigments, bleaches or dyes, may additionally be applied. Such capsules are applied by methods known per se, for example by shaking or rolling granulation or in fluid-bed processes. advantageously, are such granules, for example, by applying polymeric film-forming, low-dust and storage stable due to the coating.

Furthermore, it is possible to assemble two or more enzymes together so that a single granule has several enzyme activities.

Detergents according to the invention may contain, in addition to the at least one protease, one or more further enzymes, in particular from the following group: amylases, hemicellulases, cellulases, lipases and oxidoreductases.

The amylase (s) is preferably an α-amylase. The hemicellulase is preferably a β-glucanase, a pectinase, a pullulanase and / or a mannanase. The cellulase is preferably a cellulase mixture or a one-component cellulase, preferably or predominantly an endoglucanase and / or a cellobiohydrolase. The oxidoreductase is preferably an oxidase, in particular a choline oxidase, or a perhydrolase. The enzymes mentioned can all be formulated as described above for the proteases.

In cleaning agents according to the invention, which in one embodiment are in predominantly liquid, pasty or gel form, this is at least one enzyme, preferably the at least one protease, in an amount of 0.01-1.6% by weight, preferably 0.08-1 , 2 wt .-% based on the total weight of the cleaning agent, contained in this.

In various embodiments, the enzyme (s) may be pre-formulated with enzyme stabilizers in an enzyme composition. The enzyme protein usually forms only a fraction of the total weight of the enzyme preparation. Preferably used enzyme preparations contain between 0, 1 and 40 wt .-%, preferably between 0.2 and 30 wt .-%, particularly preferably between 0.4 and 20 wt .-% and in particular between 0.8 and 10 wt. % of the enzyme protein. In such compositions, an enzyme stabilizer may be contained in the enzyme composition in an amount of 0.05-35% by weight, preferably 0.05-10% by weight, based on the total weight. This enzyme composition can then be used in cleaning agents according to the invention in amounts which lead to the above-mentioned final concentrations in the cleaning agent. Suitable enzyme stabilizers are known in the art. Accordingly, in various embodiments, the agent according to the invention may additionally comprise one or more enzyme stabilizers.

The protein concentration can be determined by known methods, for example the BCA method (bicinchoninic acid, 2,2'-biquinolyl-4,4'-dicarboxylic acid) or the biuret method. The determination of the active protein concentration takes place in this regard via a titration of the active Centers using a suitable irreversible inhibitor (for proteases, for example, phenylmethylsulfonyl fluoride (PMSF)) and determining residual activity (see M. Bender et al., J. Am. Chem. Soc., 88, 24 (1966), pp. 5890-5913 ).

The detergents of the invention contain at least one betaine. Suitable betaines are those of the formula (R ⁱⁱⁱ ) (R ^iv ) (R ^v ) N ⁺ CH 2 COO ^" , in which R ^{i is} optionally substituted by hetero atoms or heteroatom groups, such as, for example, O, S, NH, C (O), C (O) ) NH or C (O) 0, interrupted alkyl radical having 8 to 25, preferably 10 to 21, carbon atoms and R ^iv and R ^{v are} identical or different alkyl radicals having 1 to 3 carbon atoms.C10-C18-alkyl-dimethylcarboxymethylbetain and Cn are particularly preferred -Ci7-Alkylamidopropyl-dimethylcarboxymethylbetain.

Furthermore, the detergents of the invention contain at least one anionic surfactant from the group of ether sulfates. Preferred ether sulfates are those of the formula (I)

R -O- (AO) _n -SO ₃ - X ⁺ (I).

In this formula (I) R is a linear or branched, substituted or unsubstituted alkyl radical, preferably a linear, unsubstituted alkyl radical, more preferably a fatty alcohol radical. Preferred radicals R are selected from decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl radicals and mixtures thereof, where the representatives with even number of carbon atoms are preferred. Particularly preferred radicals R are derived from C 12 -C 18 -fatty alcohols, for example coconut fatty alcohol, tallow fatty alcohol, lauryl, myristyl, cetyl or stearyl alcohol or C 10 -C 20 oxo alcohols. X stands for a monovalent cation or the n-th part of an n-valent cation, the alkali metal ions being preferred, and Na ⁺ or K ⁺ being preferred, Na ^{+ being} extremely preferred. Other cations X ⁺ can be selected from NhV,

Mn ²⁺ , and mixtures thereof.

AO represents an ethylene oxide (EO) or propylene oxide (PO) moiety, preferably an ethylene oxide moiety. The index n stands for an integer from 1 to 50, preferably from 1 to 20 and in particular from 2 to 10. Most preferably, n stands for the numbers 2, 3, 4, 5, 6, 7 or 8.

Preference is given to fatty alcohol ether sulfates of the formula 1-1

(1-1) with k = 1 1 to 19, n = 2, 3, 4, 5, 6, 7 or 8. Particularly preferred representatives are Na-Ci2-14 fatty alcohol ether sulfates with 2 EO (k = 1 1-13, n = 2 in formula 1-1).

Although not preferred, the agents of the invention may be used in addition to the above-mentioned additional surfactant. Suitable are, for example, surfactants from the groups of alkylbenzenesulfonates, alkyl sulfates, alkyl ester sulfonates, secondary alkanesulfonates, fatty alcohol alkoxylates, alkyl glycosides, alkoxylated fatty acid alkyl esters, fatty acid alkanolamides, hydroxy mixed ethers, sorbitan fatty acid esters, polyhydroxy fatty acid amides and alkoxylated alcohols. Such surfactants are known in the art.

In various embodiments of the invention, the agent does not contain amine oxide, especially C12-C18 alkyldimethylamine oxide.

In various embodiments, the total amount of surfactants, i. of the surfactant mixture, based on the weight of the composition 4 to 45 wt .-%, preferably 6 to 40 wt .-%, more preferably 10 to 25 wt .-%.

In one embodiment, the cleaning agents according to the present invention are liquid and contain water as the main solvent, i. they are aqueous cleaning agents. The water content of the aqueous composition of the present invention is usually 15 to 95% by weight, preferably 20 to 90% by weight. In various embodiments, the water content is more than 5 wt .-%, preferably more than 15 wt .-% and particularly preferably more than 25% by weight, each based on the total amount of detergent.

In addition, non-aqueous solvents may be added to the detergent. Suitable non-aqueous solvents include mono- or polyhydric alcohols, alkanolamines or glycol ethers, provided that they are miscible with water in the specified concentration range. The solvents are preferably selected from ethanol, n-propanol, i-propanol, butanols, glycol, propanediol, butanediol, methylpropanediol, glycerol, diglycol, propyldiglycol, butyldiglycol, hexyleneglycol, ethylene glycol methyl ether, ethylene glycol ethyl ether,

Ethylene glycol propyl ether, ethylene glycol mono-n-butyl ether, diethylene glycol methyl ether, diethylene glycol ethyl ether, propylene glycol methyl ether, propylene glycol ethyl ether,

Propylene glycol propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, methoxytriglycol, ethoxytriglycol, butoxytriglycol, 1-butoxyethoxy-2-propanol, 3-methyl-3-methoxybutanol, propylene glycol t-butyl ether, di-n-octyl ether and mixtures of these solvents. The one or more non-aqueous solvents is usually contained in an amount of 0.1 to 10% by weight, preferably 1 to 8% by weight, based on the total composition.

In addition to the components mentioned so far, the cleaning agents according to the invention may contain further ingredients which further improve the performance and / or aesthetic properties of the cleaning agent. These include, for example, additives for improving the drainage and drying behavior, for adjusting the viscosity and / or for stabilization, and other cleaning agents and additives customary in detergents, such as UV stabilizers, perfume, pearlescing agents, dyes, corrosion inhibitors, preservatives, bittering agents, organic Salts, disinfectants, structuring polymers, defoamers, encapsulated ingredients (eg encapsulated perfume), pH adjusters and skin feel-improving or nourishing additives.

To further improve the drainage and / or drying behavior, the composition according to the invention may comprise one or more additives from the group of polymers and builders (builder), usually in an amount of 0.001 to 5 wt.%, Preferably 0.01 to 4 Wt .-%, in particular 0, 1 to 3 wt .-%, particularly preferably 0.2 to 2 wt .-%, most preferably 0.5 to 1, 5 wt .-%, for example 1 wt .-%.

For the purposes of the present invention, polymeric thickeners are the polycarboxylates which have a thickening effect as polyelectrolytes, preferably homopolymers and copolymers of acrylic acid, in particular acrylic acid copolymers such as acrylic acid-methacrylic acid copolymers, and the polysaccharides, in particular heteropolysaccharides, and other customary thickening polymers.

Suitable polysaccharides or heteropolysaccharides are the polysaccharide gums, for example gum arabic, agar, alginates, carrageenans and their salts, guar, guar gum, tragacanth, gellan, Ramzan, dextran or xanthan and their derivatives, e.g. propoxylated guar, as well as their mixtures. Other polysaccharide thickeners, such as starches or cellulose derivatives, may be used alternatively, but preferably in addition to a polysaccharide gum, for example starches of various origins and starch derivatives, e.g. Hydroxyethyl starch, starch phosphate esters or starch acetates, or carboxymethyl cellulose or its sodium salt, methyl, ethyl, hydroxyethyl, hydroxypropyl, hydroxypropyl methyl or hydroxyethyl methyl cellulose or cellulose acetate.

Acrylic acid polymers suitable as polymeric thickeners are, for example, high molecular weight homopolymers of acrylic acid crosslinked with a polyalkenyl polyether, in particular an allyl ether of sucrose, pentaerythritol or propylene (INCI Carbomer), which are also referred to as carboxyvinyl polymers. However, particularly suitable polymeric thickeners are the following acrylic acid copolymers: (i) Copolymers of two or more monomers from the group of acrylic acid, methacrylic acid and their simple, preferably with Ci-4-alkanols formed ester (INCI acrylates copolymer), to which the copolymers of methacrylic acid, butyl acrylate and methyl methacrylate (CAS 25035-69-2) or of butyl acrylate and methyl methacrylate (CAS 25852-37-3); (ii) crosslinked high molecular weight acrylic acid copolymers, such as those crosslinked with an allyl ether of sucrose or pentaerythritol copolymers of Cio-30-alkyl acrylates with one or more monomers from the group of acrylic acid, methacrylic acid and their simple, preferably with Ci-4-alkanols formed esters (INCI acrylates / C 10-30 alkyl acrylate crosspolymer).

The content of polymeric thickener is usually not more than 8 wt .-%, preferably between 0, 1 and 7 wt .-%, particularly preferably between 0.5 and 6 wt .-%, in particular between 1 and 5 wt .-% and most preferably between 1, 5 and 4 wt .-%, for example between 2 and 2.5 wt .-%, based on the total weight of the cleaning agent.

To stabilize the composition of the invention, particularly at high surfactant content, one or more dicarboxylic acids and / or salts thereof may be added, in particular a composition of Na salts of adipic, succinic and glutaric acid, for example as available under the trade name Sokalan ^® DSC is. The use is advantageously carried out in amounts of 0.1 to 8 wt .-%, preferably 0.5 to 7 wt .-%, in particular 1, 3 to 6 wt .-% and particularly preferably 2 to 4 wt .-%, based on the total weight of the cleaning agent.

However, if it is possible to dispense with their use, the agent according to the invention is preferably free from dicarboxylic acid (salts).

In addition, one or more further can - especially in hand dishwashing detergents and cleaning agents for hard surfaces - conventional auxiliaries and additives, in particular UV stabilizers, perfumes, pearlescent agents (INCI opacifying agents, for example glycol distearate, for example Cutina ^® AGS from Cognis, respectively. this containing mixtures, for example the Euperlane ^® Fa. Cognis), dyes, corrosion inhibitors, preservatives (eg the technical referred to as Bronopol 2-bromo-2-nitropropane-1, 3-diol (CAS 52-51-7), the for example, as Myacide ^® BT or as Boots Bronopol BT from Boots is commercially available), organic salts, disinfectants, enzymes, pH-adjusting agents and skin feel-improving or skin-care additives (eg dermatologically effective substances, such as vitamin A, vitamin B2, vitamin B12 , Vitamin C, Vitamin E, D-Panthenol, Sericerin, Collagen Partial Hydrolyzate, Various Vegetable Protein Partial Hydrolyzates, Protein Hydrolyzates at-fatty acid condensates, liposomes, cholesterol, vegetable and animal oils such as lecithin, soybean oil, etc., plant extracts such as aloe vera, azulene, witch hazel extracts, algae extracts, etc., allantoin, AHA complexes, Glycerin, urea, quaternized hydroxyethyl cellulose) in amounts of usually not more than 5% by weight, based on the total weight of the cleaning agent.

The pH of the agent according to the invention can be adjusted by means of customary pH regulators, for example acids such as mineral acids or citric acid and / or alkalis such as sodium or potassium hydroxide, wherein - in particular with the desired hand tolerance - a range from 4 to 9, preferably 5 to 8, in particular 5.5 to 7.5, is preferred.

For adjusting and / or stabilizing the pH, the agent according to the invention may contain one or more buffer substances (INCI Buffering Agents), usually in amounts of 0.001 to 5 wt .-%, preferably 0.005 to 3 wt .-%, in particular 0 , 01 to 2 wt .-%, particularly preferably 0.05 to 1 wt .-%, most preferably 0.1 to 0.5 wt .-%, for example, 0.2 wt .-%. Preference is given to buffer substances which are at the same time complexing agents or even chelating agents (INCI chelating agents). Particularly preferred buffer substances are the citric acid or the citrates, in particular the sodium and potassium conduction rates, for example trisodium citrate-2H2O and tripotassium citrate H20.

The composition according to the invention can be used for cleaning hard surfaces, in particular for manual cleaning of dishes.

The preparation of the cleaning agent by means of conventional and known methods and methods.

Finally, the subject matter of the present invention is also a process for the cleaning of hard surfaces, which is characterized in that in at least one process step a composition described herein is used.

Another object of the invention is the use of a hard surface cleaning agent described herein.

Yet another subject of the invention is the use of the surfactant combinations described herein for stabilizing an enzyme, in particular a protease, in a detergent containing at least one enzyme.

All aspects, objects, and embodiments described for means described herein are also applicable to the aforementioned methods and uses. Therefore, reference is made at this point expressly to the disclosure in the appropriate place with the statement that this disclosure also applies to the above described methods and uses. Examples

Example 1: formulation according to the invention

7.5% FAEOS

4.6% betaine

0.1% protease

ad 100% perfume, color, preservative, water

Example 2: Reference recipe

7.5% FAEOS

2.8% betaine

1.8% amine oxide

0.1% protease

ad 100% perfume, color, preservative, water

All data are wt .-% of active substance based on the total weight.

Example 3: Protease Stabilization

AW 4W (50 ° C)

% RA% RA

Example 1 100 21%

Example 2 100 7%

AW: initial value; 4W: 4 weeks; RA: residual activity

It can be seen that the residual activity of the respective enzyme formulation after four weeks by the addition of the surfactant combination of the invention over the reference formulation (with amine oxide) is less reduced.

Claims

claims

1. Use of a surfactant mixture comprising:

2. Detergent, preferably dishwashing detergent, more preferably hand dishwashing detergent, containing at least one enzyme, preferably a protease, and a surfactant mixture, the surfactant mixture comprising:

3. The use according to claim 1 or the cleaning agent according to claim 2, characterized in that the agent contains no amine oxide.

4. The use or the cleaning agent according to one of the preceding claims, characterized in that the at least one enzyme, preferably the at least one protease, in an amount of 0.01 to 1, 6 wt .-%, preferably 0.08 - 1 , 2 wt .-% is contained in the cleaning agent, based on the total weight of the cleaning agent.

5. The use or cleaning agent according to one of the preceding claims, characterized in that the surfactant mixture based on the total weight of the composition in an amount of 4 to 50 wt .-%, preferably 5 to 25 wt .-%, more preferably 8 to 15 wt .-%, most preferably 10 to 12 wt .-% in this is contained.

6. The use or the cleaning agent according to one of the preceding claims, characterized in that the cleaning agent at least one additional ingredient selected from the group consisting of other surfactants, additives for Improvement of the drainage and drying behavior, for adjusting the viscosity and / or for stabilization, UV stabilizers, perfume, pearlescing agents, dyes, corrosion inhibitors, preservatives, bitter substances, organic salts, disinfectants, structuring polymers, defoamers, encapsulated ingredients, pH adjusters and Contains skin feel-improving or nourishing additives.

7. Use of a cleaning agent according to any one of claims 2 to 5 for cleaning solid surfaces, preferably as a dishwashing detergent, more preferably as a hand dishwashing detergent.

8. A method for cleaning hard surfaces, characterized in that in at least one method step, a cleaning agent, preferably dishwashing detergent, more preferably hand dishwashing detergent, according to one of claims 2 to 5 is applied.