WO2017150634A1 - 歯科材料 - Google Patents
歯科材料 Download PDFInfo
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- WO2017150634A1 WO2017150634A1 PCT/JP2017/008181 JP2017008181W WO2017150634A1 WO 2017150634 A1 WO2017150634 A1 WO 2017150634A1 JP 2017008181 W JP2017008181 W JP 2017008181W WO 2017150634 A1 WO2017150634 A1 WO 2017150634A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/08—Artificial teeth; Making same
- A61C13/087—Artificial resin teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/10—Fastening of artificial teeth to denture palates or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/50—Implements for filling root canals; Methods or instruments for medication of tooth nerve channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/898—Polysaccharides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/70—Tooth crowns; Making thereof
- A61C5/77—Methods or devices for making crowns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
Definitions
- the present invention relates to a dental material used in dentistry.
- the oral environment is partly due to breathing even when it is wet by saliva, due to changes in pH caused by ingestion of acidic or alkaline foods, changes in temperature due to ingestion of hot or cold foods , Dry occlusion, large occlusal force and impact force associated with mastication, wear due to occlusion and mastication and wear due to brushing, etc. It is a special environment where it becomes liquid and is subject to electrochemical changes. Because of these specialities, dental materials used in the oral cavity have excellent biocompatibility, mechanical strength suitable for the living body (for example, resistance to bite force in the oral cavity), and durability. It is required to be a thing.
- a metal material such as titanium is used because of durability, biocompatibility, and high compressive strength.
- a metal material such as titanium generally has a mechanical strength that is too high, and may cause adverse effects on the human body, such as a crown of a counter tooth and a crack of a tooth root.
- cellulose which is the main component of plant cell walls, has abundant resources and is excellent in terms of durability, strength, and the like, and therefore, its application in various fields is being studied.
- a resin composition having high mechanical strength and excellent impact strength and excellent moldability is obtained. It has been proposed to obtain a molded body particularly useful as an automobile member (see Patent Document 1).
- a dry film having high strength can be formed by a resin composition containing cellulose fibers and a resin emulsion satisfying a predetermined condition, and using this film forming action, an adhesive, It has been proposed to be applied as a paint, wax, or a raw material for producing them (see Patent Document 2).
- the present invention has been made in view of the circumstances as described above, has biocompatibility, has mechanical strength suitable for a living body such as resistance to occlusal force in the oral cavity, and The object is to provide a durable dental material.
- the present inventor has achieved biocompatibility and occlusal force in the oral cavity by applying nanofibers (particularly cellulose nanofibers), which have not been attempted in the field of dental materials, to dental materials. It was unexpectedly found that a dental material having mechanical strength suitable for a living body, such as resistance, and durability is provided.
- Patent Documents 1 and 2 are primarily materials that are intended for industrial use and use nanofibers as a resin reinforcing material. Specifically, a material having the strength required for industrial use is too hard as a dental material and does not have properties suitable for the special environment in the oral cavity. However, there is a problem that the dental material itself is broken or detached due to the action of the occlusal force due to occlusion or mastication. In addition to the dental material itself, not only the teeth and tissues to which the dental material is applied, but also the tissues adjacent to the dental material, symptoms such as cracks and inflammation occur due to compatibility with the dental material and differences in physical properties. There was a problem that there was concern about doing.
- thermoplastic resins and thermosetting resins In industrial applications, it is acceptable to use various thermoplastic resins and thermosetting resins. However, for example, phenol resins that are generally used at high frequency are concerned about carcinogenicity. It was impossible to use it as a raw material for dental materials used in the oral cavity.
- nanofibers especially cellulose nanofibers
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resin.
- the nanofiber is a cellulose nanofiber or a cellulose nanofiber composite.
- the nanofiber further includes one or more of chitosan nanofiber and chitin nanofiber.
- the dental material includes an antimicrobial substance.
- the dental material is an implant material, a prosthetic material, a denture material, a filler, a denture base material, a molding restoration material, or an impression material.
- the dental material is an implant material, a prosthetic material, or a denture material, and has a compressive strength within a range of 300 MPa to 400 MPa.
- the dental material is a filler and has a compressive strength in the range of 150 MPa to 250 MPa.
- the dental material is a denture base material and has a compressive strength within a range of 60 MPa to 100 MPa.
- the dental material is a molding restoration material or an impression material, and has a compressive strength within a range of 30 MPa to 50 MPa.
- the present invention provides the following.
- (Item 1) Dental material containing nanofiber and biocompatible resin.
- (Item 2) Item 2.
- (Item 3) Item 3.
- (Item 4) The dental material according to any one of items 1 to 3, wherein the dental material contains an antibacterial substance.
- (Item 5) The dental material according to any one of items 1 to 4, wherein the dental material is an implant material, a prosthetic material, a denture material, a filler, a denture base material, a molding restoration material, or an impression material.
- the dental material according to Item 5 wherein the dental material is a molding restoration material or an impression material, and has a compressive strength within a range of 30 MPa to 50 MPa.
- the compressive strength is JIS T6123, JIS T6501, JIS T6502, JIS T6503, JIS T6505, JIS T6506, JIS T6508, JIST6509, JIS T6512, JIS T6513, JIS T6514, JIS T6515, JIS T6517, JIS T6518, JIS T6519, JIST6520, JIS T6521, JIS T6522, JIS T6523, JIS T6524, JIS T6525-1, JIS T6525-2, JIS T6527, JIST6601, JIS T6604, JIS T6605, JIS T6608, JIS T6609-1, JIS T6609-2, JIS T6610 Item 10.
- Dental material A material comprising nanofibers and a resin, (1) A material further comprising a coating agent and (2) a substance selected from the group consisting of an additive selected from the group consisting of lead, tungsten, boron, graphite, graphene, and cadmium.
- Item 12 Item 11. A material according to item 11, for strengthening a fuel rod cask, as a radiation shield, or for reinforcing a body of a car, ship, spacecraft, space base, rocket, aircraft, or motorcycle.
- the material according to Item 12 As material, as adhesive material after crushing space debris, as material for debris bumper spacecraft or space base, as material for robot frame, as roof material including radiation shielding material, or as building material Material for use.
- the resin comprises methyl methacrylate (MMA), polymethyl methacrylate (PMMA), 2-hydroxyethyl methacrylate (HEMA), tri-n-butylborane (TBB), and 4-methacryloxyethyl trimellitate anhydride (4- 12.
- the coating agent is polyurea.
- the compressive strength is JIS A1106: 2006, JIS A1107; 2012, JIS A1108; 2006, JIS A1113: 2006, JISA1114; 2011, JIS A1132; 2014, JIS A1136; 1993, JIS A1142; 2007, JIS D4610: 1993, JISH7701: 2008, JIS R3222; 2003, JIS S1200; 2012, JIS S1203; 1998, JIS S1205; 1998, JISZ8841; 1; 1993, AST MD953-95, ISO / TS20746: 2016, ISO 75-3: 2004, ISO 1752020 : 2016, ISO1920-4; 2005, ISO 1920-5: 2004, ISO 2633: 1974, ISO 3185: 2008, ISO 3186: 2008, ISO3193; 2008, ISO-3202: 1997, ISO-3203; 1993, ISO- 7689; 2008, ISO-8168;
- a dental material having excellent resistance to occlusal force in the oral cavity, mechanical strength suitable for a living body, and durability is provided.
- dental material includes materials used in the oral cavity and materials for producing the same.
- a dental material eg, an implant material, prosthetic material, denture material, filler, denture base material, or molded restorative material
- a dental material eg, an implant material, prosthetic material, denture material, filler, denture base material, or molded restorative material
- a dental material applied to the oral cavity is applied to at least a portion of the dental material when applied to the oral cavity. This means that the occlusal force by occlusion or mastication acts directly or indirectly.
- examples of the dental material of the present invention include implant materials, prosthetic materials (inlays, crowns, cores, bridges, etc.), denture materials (artificial teeth), denture base materials (denture base stabilizers, denture bases). ), Molding restoration materials (root canal filling material, gutta percha material, pit and fissure filling material, other sealers, sealants, etc.), impression material (molding material), filling material (filling resin) Etc.), a model material, a wax material, an investment material, a bonding material and the like, but are not limited thereto.
- nanofiber refers to a fibrous substance having a nanoscale with an average outer diameter in the range of 1 nm to 100 nm and having a length that is at least 100 times the average outer diameter.
- examples of the nanofiber include a nanotube having a hollow structure, a nanorod having no hollow structure, and a nanowire having a conductive or semiconductive property.
- biocompatibility refers to harm that exceeds at least the desired intended effect with respect to the interaction between the dental material and the living body, as well as the local and systemic reactions of the tissue adjacent to the dental material. It means not giving.
- the biocompatibility of the implant material means that the living body recovers its function and / or at the interface between the living body to which the implant material is applied and the implant material. It refers to the property of being able to heal and provide the state in which the implant material remains functional.
- the biocompatibility of the dental material can be evaluated, for example, from the viewpoints of surface (interface) compatibility and mechanical compatibility.
- implant material refers to a material used by being embedded in the submucosa or jawbone in the oral cavity.
- the implant material include, but are not limited to, an intraosseous implant, a subperiosteal implant, and an endodontic intraosseous implant.
- the “prosthetic material” refers to a material used to repair a tooth defect.
- Examples of prosthetic materials include, but are not limited to, inlays, crowns, cores, bridges, and the like.
- a material containing the nanofiber of the present invention and a biocompatible material is excellent as a dental material.
- the dental material of the present invention comprises nanofibers and a biocompatible resin.
- the cellulose nanofiber is not particularly limited, and a commercially available product or a product produced by a known production method may be used.
- raw materials used for producing cellulose nanofibers include plant-derived fibers contained in wood, bamboo, hemp, jute, kenaf, cotton, beet and the like.
- a preferable raw material is wood, for example, pine, cedar, cypress, eucalyptus, acacia and the like.
- paper obtained using these woods as raw materials, waste paper, or the like can also be used.
- a plant-derived fiber may be used individually by 1 type, and may use 2 or more types together.
- examples of the cellulose nanofiber include pulp obtained from the plant fiber-containing material, cellulose nanofiber subjected to mercerization, and regenerated cellulose nanofiber such as rayon, cellophane, and lyocell. From the viewpoint of resource recycling, it is preferable to use cellulose nanofibers obtained from waste materials or agricultural waste.
- the cellulose nanofiber is referred to as a composite of cellulose nanofiber and another substance (referred to as “cellulose nanofiber composite” in the present specification) depending on the type and use of dental material, required characteristics, and the like. ) May be used.
- examples of other substances that are combined with cellulose nanofibers include calcium carbonate, tricalcium phosphate, and calcium sulfate.
- the use of a composite of cellulose nanofibers and calcium carbonate and a composite of cellulose nanofibers and tricalcium phosphate are preferably considered.
- a cellulose nanofiber may be used individually by 1 type, and may use 2 or more types together.
- nanofibers may be used alone or in combination of two or more.
- the nanofibers preferably further include one or more of chitosan nanofibers and chitin nanofibers.
- the antibacterial property of a dental material can be improved more.
- the type and combination of nanofibers can be appropriately selected according to the type and use of dental material, required characteristics, and the like.
- the biocompatible resin include monomers such as acrylic acid, acrylic acid ester, methacrylic acid, methacrylic acid ester, carbonate, propylene, styrene, amide, imide, glycolic acid, lactic acid, maltose, and dextrin, oligomers, and polymers.
- examples of the biocompatible resin include methyl methacrylate (MMA), polymethyl methacrylate (PMMA); ethyl methacrylate (EMA), n-butyl methacrylate, isobutyl methacrylate, tert-butyl methacrylate, 2-ethylhexyl.
- MMA methyl methacrylate
- PMMA polymethyl methacrylate
- EMA ethyl methacrylate
- n-butyl methacrylate isobutyl methacrylate
- tert-butyl methacrylate 2-ethylhexyl.
- Alkyl esters of methacrylic acid such as methacrylate, n-lauryl methacrylate, alkyl (C12-13) methacrylate, n-stearyl methacrylate, tridecyl methacrylate; dimethylaminoethyl methacrylate, methyl chloride salt of dimethylaminoethyl methacrylate, dimethylaminoethyl methacrylate Dialkylaminoethyl esters of methacrylic acid such as benzyl chloride salt and diethylaminoethyl methacrylate; Carboxylic acid-containing esters of methacrylic acid such as loxyethyl phthalate, 2-methacryloyloxyethyl phthalate, 2-methacryloyloxyethyl hexahydrophthalate; fluoroalkyl esters of methacrylic acid such as 2,2,2-trifluoroethyl methacrylate; cyclohe
- MMA, PMMA, HEMA, TBB, and 4-META are preferably considered.
- a biocompatible resin may be used individually by 1 type, and may use 2 or more types together.
- the dental material which concerns on this embodiment contains an antibacterial substance. Thereby, the antibacterial property of a dental material can be improved more.
- the antibacterial substance is not particularly limited as long as it is a substance having antibacterial activity and does not adversely affect the human body, and can be appropriately selected according to the type and use of dental materials, required characteristics, and the like.
- Examples thereof include, but are not limited to, chitosan (including chitosan derivatives), chitin (including chitin derivatives), drugs having antibacterial activity, metal ions (for example, copper ions, silver ions, etc.), and the like.
- antibacterial agents, metal ions, etc. as antibacterial substances, from the viewpoint of more effectively exhibiting the antibacterial properties of dental materials, include those antibacterial substances in microcapsules and include them in dental materials. Are preferably considered. (4.
- the dental material includes a lubricant, a wax, a colorant, a stabilizer, a filler, and other various additives as long as the effects of the present invention are not impaired. May be included.
- a compatibilizing agent may be added to the dental material in order to facilitate mixing of the nanofibers and the biocompatible resin.
- a coloring agent may be added to the dental material according to the color tone of the living body to which the dental material is applied and / or the tissue adjacent to the dental material.
- the dental material according to the present embodiment can be subjected to a modification treatment such as a surface modification treatment according to the type and application of the dental material, required characteristics, and the like.
- a modification treatment such as a surface modification treatment according to the type and application of the dental material, required characteristics, and the like.
- the hydrophilic / hydrophobic property of the dental material can be adjusted by coating the whole or part of the surface of the dental material with a hydrophilic or hydrophobic substance.
- the dental material of the present invention can typically be evaluated for its mechanical properties, physical properties, chemical properties, biological stability, mechanical stability, etc. using the following items as indices.
- the compressive strength is obtained by measuring a dental material sample as JIST6123, JIS T6501, JIS T6502, JIS T6503, JIS T6505, JIS T6506, JIS T6508, JIS T6509, JIST6512, JIST6513, JIS T6514, JIS T6515.
- the compressive strength may apply the same test method irrespective of the type of dental material, or may apply a different test method depending on the type of dental material.
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resin, it has excellent resistance to occlusal force in the oral cavity.
- the dental material of the present invention can appropriately control the compressive strength, it is possible to prevent cracking of the root caused by the compressive strength being too high. Compared to conventional dental materials.
- the elastic modulus (GPa) and / or the yield value (MPa) of the dental material of interest are measured by an arbitrary testing machine in accordance with a normal test method.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it is manufactured so as to have the same or superior elastic modulus and / or yield value as compared with conventional dental materials. It is possible.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it has the same or superior bending strength and / or bending elastic modulus as compared with conventional dental materials. It is possible to manufacture.
- the impact strength (kgf ⁇ cm / cm) of the target dental material is measured by a known Charpy method, Izod method or the like.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it can be manufactured to have equivalent or superior impact strength compared to conventional dental materials. is there.
- the Brinell hardness (H B ), Vickers hardness (H v ), Knoop hardness (H K ), Shore hardness, etc. of the target dental material are measured by a known indentation method, elasticity method, scratching method, etc. .
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it can be manufactured to have the same or superior hardness as compared with conventional dental materials. .
- the fracture toughness (MN / m 3/2 ) of the target dental material is measured by a generally known IM method, CSF method, CN method, SENB method or the like.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it can be manufactured to have the same or superior fracture toughness as compared with conventional dental materials. .
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resin, it is superior in dimensional stability compared to conventional dental materials.
- it is possible to more accurately control the shape and size after curing by making implant materials and denture materials and impression materials (molding materials) with dental materials of the same component It is.
- the wear resistance of the target dental material is measured by a known wear / friction tester or the like.
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resin, it is superior in wear resistance compared to conventional dental materials.
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resin, the dimensional change is suppressed.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it has excellent chemical stability against both acid and alkali.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin. Since the nanofibers and the biocompatible resin are compounded in a close state, compared with conventional dental materials. Has equivalent or superior water resistance.
- the porosity (%) and / or the pore diameter ( ⁇ m, nm) are measured by electron microscopy.
- the dental material of the present invention is a dental material containing nanofibers and biocompatible resins, and the nanofibers and biocompatible resins are complexed in a close state, so that the porosity is minimal.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, and since the nanofibers and the biocompatible resin are compounded in a close state, the appearance is good, and Since it has a color similar to that of teeth, it has good aesthetics.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin. Since the nanofibers and the biocompatible resin are compounded in a close state, compared with conventional dental materials. It has excellent color stability and retains aesthetics over a longer period. Further, since the dental material of the present invention is a white material having high transparency, it is possible to easily achieve a desired color tone by adjusting the kind and amount of the colorant added during the production.
- the dental material of the present invention is a dental material containing nanofibers and a biocompatible resin, it has the same or better biocompatibility than conventional dental materials. (7. Specific examples of dental materials)
- an implant material, a prosthetic material, a denture material, a filler, a denture base material, a molding restoration material, and an impression material will be described.
- the dental material of the present invention is an implant material, a prosthetic material or a denture material, and has a compressive strength in the range of 300 MPa to 400 MPa.
- the compressive strength in the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6123.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6501.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6502.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIS T6503. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIST6505. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6506. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6508. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6509.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6512. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIS T6513. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6514. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIS T6515. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6517.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6518. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6519. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6520. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6521. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIS T6522.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6523. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIS T6524. In another aspect of the present embodiment, the compressive strength in the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6525-1. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6525-2. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIST6527.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6601. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIST6604. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6605. In another aspect of the present embodiment, the compressive strength in the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6608. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6609-1.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing according to JIST6609-2. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6610. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6611. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6612.
- the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS T6003. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIST6005. In another aspect of the present embodiment, the compressive strength within the range of 300 MPa to 400 MPa is obtained by testing in accordance with JIS K 7718. More specifically, for example, the compressive strength in the range of 300 MPa to 400 MPa in the denture material according to the present embodiment can be obtained by testing in accordance with JIST6517.
- the compressive strength in the range of 300 MPa to 400 MPa in the denture material according to the present embodiment can be obtained by testing in accordance with JIS T6518. Further, the compressive strength within the range of 300 MPa to 400 MPa in the denture material according to the present embodiment can be obtained by testing in accordance with JIST6525-1. Further, the compressive strength within the range of 300 MPa to 400 MPa in the denture material according to the present embodiment can be obtained by testing in accordance with JIST6525-2.
- the content of the nanofiber with respect to the total mass of the dental material is preferably in the range of 70% to 90%, more preferably in the range of 75% to 90%, and more preferably in the range of 80% to 90%. More preferably, it is within the range of 85%.
- the ratio of biocompatible resin among components other than the nanofiber in the dental material is at least 90% or more.
- those content can be suitably set according to the kind of dental material, a use, a required characteristic, etc.
- an implant material, prosthetic material, or denture material having mechanical strength suitable for an application site of an implant material, prosthetic material, or denture material in a living body, excellent in dimensional stability, and excellent in wear resistance. be able to.
- the compressive strength of the implant material, prosthetic material or denture material according to the present embodiment can be controlled, when these are applied to the oral cavity, it is possible to suppress an excessive burden on the teeth when an occlusal force is applied. Is done.
- the antibacterial property of the implant material, prosthetic material, or denture material according to the present embodiment makes it difficult for plaque to adhere to the teeth and is less likely to be affected by bacteria, so that secondary caries can be suppressed.
- the dental material of the present invention is a filler and has a compressive strength in the range of 150 MPa to 250 MPa.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6123.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6501.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6502.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6503.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6505. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6506. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6508. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6509. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6512.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6513. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6514. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6515. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIST6517. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6518.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6519. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6520. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6521. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6522. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6523.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6524. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6525-1. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6525-2. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6527. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6601.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6604. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing according to JIS T6605.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6608. In another aspect of the present embodiment, the compressive strength in the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6609-1. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6609-2. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6610. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6611.
- the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6612. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS T6003. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIST6005. In another aspect of the present embodiment, the compressive strength within the range of 150 MPa to 250 MPa is obtained by testing in accordance with JIS K 7718.
- the content of the nanofiber with respect to the total mass of the dental material is preferably in the range of 50% to 80%, more preferably in the range of 55% to 75%, and more preferably 60% to More preferably, it is in the range of 70%.
- the ratio of biocompatible resin among components other than the nanofiber in the dental material is at least 90% or more.
- those content can be suitably set according to the kind of dental material, a use, a required characteristic, etc.
- the dental material of the present invention is a denture base material and has a compressive strength in the range of 60 MPa to 100 MPa.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6123.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6501.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6502.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6503.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6505. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6506. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6508. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6509. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6512.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6513. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6514. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6515. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6517. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6518.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6519. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6520. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6521. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6522. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6523.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6524. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6525-1. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIST6525-2. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6527. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6601.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6604. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6605. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing according to JIS T6608. In another aspect of the present embodiment, the compressive strength in the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6609-1. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6609-2.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6610. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6611. In another aspect of the present embodiment, the compressive strength in the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6612. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS T6003. In another aspect of the present embodiment, the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIST6005.
- the compressive strength within the range of 60 MPa to 100 MPa is obtained by testing in accordance with JIS K 7181. More specifically, for example, the compressive strength in the range of 60 MPa to 100 MPa in the denture base material according to the present embodiment can be obtained by testing in accordance with JIST6501.
- the content of the nanofiber with respect to the total mass of the dental material is preferably in the range of 30% to 70%, more preferably in the range of 35% to 65%, and more preferably in the range of 40% to More preferably, it is in the range of 60%.
- the ratio of biocompatible resin among components other than the nanofiber in the dental material is at least 90% or more.
- those content can be suitably set according to the kind of dental material, a use, a required characteristic, etc.
- a denture base material having mechanical strength suitable for the application site of the denture base material in a living body, excellent in dimensional stability, and excellent in wear resistance can be obtained.
- the denture base material according to the present embodiment the denture base material and the denture material can be made from a common component, so that dimensional deviation that may occur when the materials are different is suppressed, More precise control of dimensions is possible, and biocompatibility as a whole dental material is further improved.
- the dental material of the present invention is a molding restorative material and has a compressive strength in the range of 30 MPa to 50 MPa.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6123.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6501.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6502.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6503. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6505. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6506. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6508. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6509.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6512. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6513. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6514. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6515. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6517.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6518. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6519. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6520. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6521. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6522.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6523. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6524. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6525-1. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6525-2. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6527.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6601. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIST6604. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6605. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIST6608. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6609-1.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6609-2. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6610. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6611. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6612. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6003.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6005. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JISK 7181. More specifically, for example, the compressive strength in the range of 30 MPa to 50 MPa in the molding / restoring material according to the present embodiment can be obtained by testing in accordance with JIST6514. Further, the compressive strength within the range of 30 MPa to 50 MPa in the molding / restoring material according to the present embodiment can be obtained by testing in accordance with JIS T6515.
- the compressive strength within the range of 30 MPa to 50 MPa in the molding / restoring material according to this embodiment can be obtained by testing in accordance with JIST6522. Further, the compressive strength within the range of 30 MPa to 50 MPa in the molding / restoring material according to the present embodiment can be obtained by testing in accordance with JIS T6524.
- the content of the nanofiber with respect to the total mass of the dental material is preferably at least 20% or more, more preferably in the range of 20% to 50%, and in the range of 20% to 45%. More preferably, it is within. Moreover, it is preferable that the ratio of biocompatible resin among components other than the nanofiber in the dental material is at least 90% or more. Moreover, when mix
- the molding / restoring material having mechanical strength suitable for an application site of the molding / restoring material in a living body, excellent in dimensional stability, and excellent in wear resistance.
- the compressive strength of the shaping restoration material which concerns on this embodiment is controllable, when it applies to an oral cavity, when an occlusal force is added, it will suppress that an excessive burden is applied to a tooth
- the antibacterial property of the molding restorative material according to the present embodiment makes it difficult for plaque to adhere to the teeth and is less likely to be attacked by bacteria, so that secondary caries can be suppressed.
- the dental material of the present invention is an impression material and has a compressive strength in the range of 30 MPa to 50 MPa.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6123.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6501.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6502.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6503.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6505. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6506. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6508. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6509. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6512.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6513. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6514. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6515. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6517. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6518.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6519. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6520. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6521. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6522. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6523.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6524. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6525-1. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS T6525-2. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6527.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6601. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIST6604. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6605. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIST6608. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6609-1.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6609-2. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6610. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6611. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6612.
- the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIS T6003. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing in accordance with JIST6005. In another aspect of the present embodiment, the compressive strength within the range of 30 MPa to 50 MPa is obtained by testing according to JIS K 7718. More specifically, for example, the compressive strength within the range of 30 MPa to 50 MPa in the impression material according to the present embodiment can be obtained by testing in accordance with JIST6512. Further, the compressive strength within the range of 30 MPa to 50 MPa in the impression material according to the present embodiment can be obtained by testing in accordance with JIS T6513. In addition, the compressive strength within the range of 30 MPa to 50 MPa in the impression material according to the present embodiment can be obtained by testing in accordance with JIST6527.
- the content of the nanofiber with respect to the total mass of the dental material is preferably at least 20% or more, more preferably in the range of 20% to 50%, and in the range of 20% to 45%. More preferably, it is within. Moreover, it is preferable that the ratio of biocompatible resin among components other than the nanofiber in the dental material is at least 90% or more. Moreover, when mix
- the dental material of the present invention is produced by mixing (melt-kneading) nanofibers and biocompatible resin at a predetermined ratio. As a mixing method, generally known methods can be applied.
- a uniaxial kneader, a multi-axial kneader, a kneader, or the like can be used, and the blending order of nanofibers and biocompatible resin in the mixing step, the timing of melting, etc. are not particularly limited.
- the nanofiber and the biocompatible resin may be melted and kneaded, or the biocompatible resin may be melted in advance, and the nanofiber may be added and mixed during kneading.
- blending order, the timing of melting, etc. can be adjusted suitably.
- the mixing temperature is not particularly limited, and can be appropriately set according to the types and combinations of nanofibers and biocompatible resins.
- the mixing ratio of the nanofiber and the biocompatible resin can be appropriately adjusted according to the type and use of the dental material, required characteristics, and the like.
- a dispersion medium can be used from the viewpoint of ensuring dispersibility between the nanofiber and the biocompatible resin.
- the dispersion medium can be appropriately selected according to the type and combination of nanofibers and biocompatible resin.
- alcohols such as water, methanol, ethanol, isopropanol, dimethylformamide, N-methyl-2- Examples thereof include amides such as pyrrolidone (NMP), and mixed solvents thereof.
- the dispersion medium can be dispersed more uniformly in consideration of the affinity between the nanofibers and the biocompatible resin and the dispersion medium in the range that does not inhibit the purpose and effect of the present invention, for example, Sodium dodecylbenzenesulfonate, sodium dodecyl sulfate, sodium cholate, sodium deoxycholate and the like may be added as a dispersant, and other additives may be added according to the required purpose.
- the dental material thus obtained can be used as it is as a target dental material, or can be molded as necessary to obtain a target dental material.
- the dental material of the present invention is molded with high dimensional accuracy by filling (filling) the cavity as a filling material as it is, performing a curing treatment, and then shaping and polishing fine parts using a grinding tool or the like. Can be processed.
- the dental material of the present invention can be molded into a desired inlay, crown, or the like using a CAD / CAM system.
- the target inlay, A crown or the like can be molded with high dimensional accuracy.
- the target inlay, A crown or the like can be molded with high dimensional accuracy.
- the material containing the nanofiber and the biocompatible material of the present invention is excellent not only for dental materials but also for other applications. ⁇ A.
- the material containing the nanofiber of the present invention and the biocompatible material described in ⁇ Dental Material> may be used other than the dental material, for example, for reinforcing a fuel rod cask, as a radiation shield, or as a car, ship, As a stiffener for spacecraft, space base, rocket, aircraft, or motorcycle body, as adhesive material after crushing space debris, as material for debris bumper spacecraft or space base, or material for robot frame Or as a roofing material containing a radiation shielding material or as a building material.
- the above ⁇ A a coating agent and / or an additive can be added to the material containing the nanofiber of the present invention and the biocompatible material described in ⁇ Dental Material>.
- nanofiber As nanofiber, ⁇ A.
- the nanofibers of the present invention described in ⁇ Dental Material> can be used.
- Examples of the nanofiber include, but are not limited to, cellulose nanofiber.
- biocompatible resin of the present invention described in ⁇ Dental material> can be used.
- Biocompatible resins include methyl methacrylate (MMA), polymethyl methacrylate (PMMA), 2-hydroxyethyl methacrylate (HEMA), tri-n-butylborane (TBB), and 4-methacryloxyethyl trimellitate anhydride.
- a resin selected from the group consisting of (4-META), for example, 4-META is exemplified, but not limited thereto.
- biocompatibility is not important in applications other than dental materials, the above ⁇ A. The biocompatibility is not necessarily required as long as the resin has the same properties as the biocompatible resin described in Dental Materials>.
- polyurea can be used, but is not limited thereto.
- additive for example, lead, tungsten, boron, graphite, graphene, cadmium, and a mixture thereof can be selected according to the purpose of use.
- Other optional additives may be added to the material of the present invention depending on the purpose.
- the moisture of the raw material can be replaced with the monomer of the adhesive material to perform hydrophobic processing, thereby increasing the adhesive strength of the material It is. Further, when a material is driven into a formwork or a frame, vibrations of 20 Hz to 50 Hz, 50 Hz to 120 Hz, and / or 120 Hz to 240 Hz can be intermittently applied to create a stronger molded body.
- the material of the present invention preferably has a strength of 1 GPa to 3 GPa (typically compressive strength), but is not limited thereto.
- the strength (typically compressive strength) is determined according to JIS ⁇ A1106: 2006, JIS A1107; 2012, JIS; A1108; 2006, JIS A1113: 2006, JISA1114; 2011, JIS A1132; 2014, JIS A1136; 1993, JIS A1142; 2007, JIS46D4610: 1993, JISH7701: 2008, JIS R3222; 2003, JIS S1200; 2012, JIS S1203; 1998, JIS S1205; 1998, JISZ8841; 1; 1993, AST MD953-95, ISO / TS20746: 2016, ISO75-3: 2004, ISO175752020: 2016, ISO1920-4; 2005, ISO1920-5: 2004, ISO2633: 1974, ISO3185: 2008, ISO3186: 2008, ISO3193; 2008, , ISO-3202: 1997, ISO3185: 2008, ISO
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JIS A1106: 2006.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JIS A1107; 2012.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JIS A1108; 2006.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JIS A 1113: 2006.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JISA1114; 2011. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JIS A1132; 2014. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JISA1136; 1993. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JISA1142; 2007.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JISD4610: 1993. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JIS H7701: 2008. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JISR3222; 2003. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with JISS1200; 2012.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JISS1203; 1998.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JISS1205; 1998.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with JISZ8841; 1; 1993.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing according to ASTM D953-95.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing according to ISO / TS20746: 2016. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO75-3: 2004. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO1752020: 2016. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO1920-4; 2005.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO 1920-5: 2004. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO 2633: 1974. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO 3185: 2008. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO 3186: 2008.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO 3193; 2008. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-3202: 1997. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-3203; 1993. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-7689; 2008.
- a strength (typically compressive strength) within the range of 1 GPa to 3 GPa is obtained by testing according to ISO-8168; 2016. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing according to ISO-5856; 2008. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-5857; 2008. In another aspect of this embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing according to ISO-7173; 1989.
- strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-7176; 8; 2014.
- a strength (typically compressive strength) within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-9152; 1998.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-9154; 2016.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-9254: 1993.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-9255; 2008. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-9256; 1993. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing in accordance with ISO-9709; 2005. In another aspect of the present embodiment, a strength within the range of 1 GPa to 3 GPa (typically compressive strength) is obtained by testing according to ISO-9845-1; 1992.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-12258; 1998.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing according to ISO-12260; 2016.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing in accordance with ISO-12261; 2016.
- a strength within the range of 1 GPa to 3 GPa is obtained by testing according to ISO-1391; 2008.
- Example 1 Cellulose nanofibers are used as nanofibers, methacrylate monomers and polymethacrylates are used as biocompatible resins, and dispersed in water so that the mass ratio of nanofibers to biocompatible resins is 85:15, and stirred well. Then, it is put into a kneader and melt kneaded at a predetermined temperature for an appropriate time to obtain a dental material.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 83:17.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 88:12.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 80:20.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 75:25.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that a composite of cellulose nanofiber and calcium carbonate is used as the nanofiber.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that cellulose nanofibers and chitosan nanofibers mixed at a mass ratio of 90:10 are used as the nanofibers.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a microcapsule encapsulating copper ions as an antibacterial substance was used, and the same as in Example 1, except that the mass ratio was 85: 13: 2. Get the material.
- This dental material is molded into a predetermined shape to obtain an implant material, a prosthetic material, and a denture material.
- a dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 65:35.
- This dental material is used as a filler.
- Example 10 A dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 50:50.
- This dental material is a denture base material.
- Example 11 A dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 30:70.
- This dental material is used as a molding restorative material.
- Example 12 A dental material is obtained in the same manner as in Example 1 except that the mass ratio of the nanofiber and the biocompatible resin is 20:80.
- This dental material is used as an impression material.
- the dental materials obtained in this way are all excellent in resistance to occlusal force in the oral cavity, have mechanical strength suitable for living organisms, have excellent dimensional stability, and have durability. ing.
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Abstract
Description
(項目1)
ナノファイバーと生体適合性樹脂とを含む歯科材料。
(項目2)
前記ナノファイバーが、セルロースナノファイバーである、項目1に記載の歯科材料。
(項目3)
前記ナノファイバーが、キトサンナノファイバーおよびキチンナノファイバーのうちの一種以上をさらに含む、項目2に記載の歯科材料。
(項目4)
前記歯科材料が抗菌物質を含む、項目1から3のうちのいずれか一項に記載の歯科材料。
(項目5)
前記歯科材料が、インプラント材、補綴材、義歯材、充填材、義歯床材、成形修復材または印象材である、項目1から4のうちのいずれか一項に記載の歯科材料。
(項目6)
前記歯科材料がインプラント材、補綴材または義歯材であり、300MPa~400MPaの範囲内の圧縮強さを有する、項目5に記載の歯科材料。
(項目7)
前記歯科材料が充填材であり、150MPa~250MPaの範囲内の圧縮強さを有する、項目5に記載の歯科材料。
(項目8)
前記歯科材料が義歯床材であり、60MPa~100MPaの範囲内の圧縮強さを有する、項目5に記載の歯科材料。
(項目9)
前記歯科材料が成形修復材または印象材であり、30MPa~50MPaの範囲内の圧縮強さを有する、項目5に記載の歯科材料。
(項目10)
前記圧縮強さが、JIS T6123、JIS T6501、JIS T6502、JIS T6503、JIS T6505、JIS T6506、JIS T6508、JIST6509、JIS T6512、JIS T6513、JIS T6514、JIS T6515、JIS T6517、JIS T6518、JIS T6519、JIST6520、JIS T6521、JIS T6522、JIS T6523、JIS T6524、JIS T6525-1、JIS T6525-2、JIS T6527、JIST6601、JIS T6604、JIS T6605、JIS T6608、JIS T6609-1、JIS T6609-2、JIS T6610、JIS T6611、JIST6612、JIS T6003、JIS T6005、およびJIS K 7181から選択される1つ以上の規格に準拠して試験することによって得られる、項目6~9のうちのいずれか一項に記載の歯科材料。
(項目11)
ナノファイバーと樹脂とを含む材料であって、さらに、
(1)コーティング剤、ならびに
(2)鉛、タングステン、ホウ素、グラファイト、グラフェン、およびカドミニウムからなる群から選択される添加剤
からなる群から選択される物質をさらに含む材料。
(項目12)
項目11に記載の材料であって、燃料棒のキャスクの強化のため、あるいは、放射線遮蔽物として、あるいは、車、船、宇宙船、宇宙基地、ロケット、航空機、または、モーターサイクルのボディの補強材として、あるいは、スペースデブリ破砕後接着材料として、あるいは、デブリバンパー宇宙船または宇宙基地の材料として、あるいは、ロボットフレームの材料として、あるいは、放射線遮蔽材料を含む屋根材として、あるいは、建築材料として使用するための、材料。
(項目13)
前記ナノファイバーが、セルロースナノファイバーである、項目11に記載の材料。
(項目14)
前記樹脂が、メチルメタクリレート(MMA)、ポリメチルメタクリレート(PMMA)、2-ヒドロキシエチルメタクリレート(HEMA)、トリ-n-ブチルボラン(TBB)、および、4-メタクリロキシエチルトリメリテートアンハイドライド(4-META)からなる群から選択される、項目11に記載の材料。
(項目15)
前記コーティング剤が、ポリウレアである、項目11に記載の材料。
(項目16)
1GPa~3GPaの範囲内の圧縮強さを有する、項目11~15のいずれか一項に記載の材料。
(項目17)
前記圧縮強さが、JIS A1106:2006、JIS A1107;2012、JIS A1108;2006、JIS A1113:2006、JISA1114;2011、JIS A1132;2014、JIS A1136;1993、JIS A1142;2007、JIS D4610:1993、JISH7701:2008、JIS R3222;2003、JIS S1200;2012、JIS S1203;1998、JIS S1205;1998、JISZ8841;1;1993、AST MD953-95、ISO/TS20746:2016、ISO 75-3:2004、ISO 1752020:2016、ISO1920-4;2005、ISO 1920-5:2004、ISO 2633:1974、ISO 3185:2008、ISO 3186:2008、ISO3193;2008,、ISO-3202:1997、ISO-3203;1993、ISO-7689;2008、ISO-8168;2016、ISO-5856;2008、ISO-5857;2008、ISO-7173;1989、ISO-7176;8;2014、ISO-9152;1998、ISO-9154;2016、ISO-9254:1993、ISO-9255;2008、ISO-9256;1993、ISO-9709;2005、ISO-9845-1;1992、ISO-12258;1998、ISO-12260;2016、ISO-12261;2016、ISO-1391;2008から選択される1つ以上の規格に準拠して試験することによって得られる、項目16に記載の歯科材料。
<定義>
本明細書において、「歯科材料」とは、口腔内で用いられる材料およびそれを作製するための材料を包含する。口腔内に適用される歯科材料(例えば、インプラント材、補綴材、義歯材、充填材、義歯床材、または、成形修復材)は、口腔内に適用された際に、少なくともその一部分に対して咬合または咀嚼による咬合力が直接的または間接的に作用するものをいう。
<A.歯科材料>
本発明のナノファイバーと生体適合性材料を含む材料は、歯科材料として優れている。一実施形態において、本発明の歯科材料は、ナノファイバーと生体適合性樹脂とを含む。
(1.ナノファイバー)
ナノファイバーとしては、特に審美性の観点から、白色もしくは乳白色のものを用いることが好ましい。例えば、セルロースナノファイバーは、生体適合性を有し、再生可能な天然資源であるため、歯科材料としての所要の特性を得る観点に加えて、環境保護や資源リサイクルの観点からも好ましく用いることができる。
(2.生体適合性樹脂)
生体適合性樹脂としては、例えば、アクリル酸、アクリル酸エステル、メタクリル酸、メタクリル酸エステル、カーボネート、プロピレン、スチレン、アミド、イミド、グリコール酸、乳酸、マルトース、デキストリン等のモノマー、オリゴマーおよびポリマー等が挙げられるが、これらに限定されない。より具体的には、生体適合性樹脂としては、例えば、メチルメタクリレート(MMA)、ポリメチルメタクリレート(PMMA);エチルメタクリレート(EMA)、n-ブチルメタクリレート、イソブチルメタクリレート、tert-ブチルメタクリレート、2-エチルヘキシルメタクリレート、n-ラウリルメタクリレート、アルキル(C12~13)メタクリレート、n-ステアリルメタクリレート、トリデシルメタクリレート等のメタクリル酸のアルキルエステル;ジメチルアミノエチルメタクリレート、ジメチルアミノエチルメタクリレートのメチルクロライド塩、ジメチルアミノエチルメタクリレートのベンジルクロライド塩、ジエチルアミノエチルメタクリレート等のメタクリル酸のジアルキルアミノエチルエステル;メタクリロキシエチルフタレート、2-メタクリロイルオキシエチルフタレート、2-メタクリロイルオキシエチルヘキサヒドロフタレート等のメタクリル酸のカルボン酸含有エステル;2,2,2-トリフルオロエチルメタクリレート等のメタクリル酸のフルオロアルキルエステル;シクロヘキシルメタクリレート、フェニルメタクリレート、ベンジルメタクリレート、イソボルニルメタクリレート、グリシジルメタクリレート、テトラヒドロフルフリルメタクリレート、アリルメタクリレート、2-ヒドロキシエチルメタクリレート(HEMA)、2-ヒドロキシプロピルメタクリレート、2-メトキシエチルメタクリレート、2-エトキシエチルメタクリレート、ヒドロキシナフトキシプロピルメタクリレート(HNPM)、エチレングリコールジメタクリレート(EDMA)、トリエチレングリコールジメタクリレート(TriEDMA)、1,3-ブタンジオールジメタクリレート(1,3-BuDMA)、1,3-ブチレングリコールジメタクリレート、1,6-ヘキサンジオールジメタクリレート、ポリプロピレングリコールメタクリレート、トリメチロールプロパントリメタクリレート、2,2-ビス[4-(2-ヒドロキシ-3-メタクリロキシプロポキシ)フェニル]プロパン(Bis-GMA)、2,2-ビス(4-メタクリロキシフェニル)プロパン(BPDMA)、2,2-ビス(4-メタクリロキシエトキシフェニル)プロパン(Bis-MEPP)、ジ(メタクリロキシエチル)トリメチルヘキサメチレンジウレタン(UDMA)、トリ-n-ブチルボラン(TBB)、メタクリロキシエチルフェニルホスフェート(Phenyl-P)、4-メタクリロキシエチルトリメリテートアンハイドライド(4-META)、4-メタクリロキシエチルトリメリット酸(4-MET)、11-メタクリロキシ-1,1-ウンデカジカルボン酸(MAC-10)、10-メタクリロキシデカメチレンリン酸(MDP)、4-アクリロキシエチルトリメリット酸(4-AET)等が挙げられるが、これらに限定されない。これらのうち、MMA、PMMA、HEMA、TBB、4-METAを用いることが好ましく考慮される。なお、生体適合性樹脂は、一種を単独でも用いてもよく、二種以上を併用してもよい。
(3.抗菌物質)
また、本実施形態に係る歯科材料は、抗菌物質を含むことが好ましい。これにより、歯科材料の抗菌性をより向上させることができる。抗菌物質としては、抗菌活性を有する物質であって人体に悪影響を与えない限りにおいて特に限定されず、歯科材料の種類や用途、所要の特性等に応じて適宜選択することができる。例えば、キトサン(キトサン誘導体を含む)、キチン(キチン誘導体を含む)、抗菌活性を有する薬剤、金属イオン(例えば、銅イオン、銀イオン等)などが挙げられるが、これらに限定されない。また、抗菌物質として抗菌活性を有する薬剤、金属イオン等を用いる場合、歯科材料の抗菌性をより効果的に発揮させる観点から、それらの抗菌物質をマイクロカプセルに内包させて、歯科材料に含めることが好ましく考慮される。
(4.その他の添加剤)
なお、本実施形態に係る歯科材料においては、必要に応じて、本発明の効果を阻害しない範囲において、歯科材料に滑材、ワックス類、着色剤、安定剤、フィラー、その他の各種の添加剤を含めてもよい。例えば、ナノファイバーと生体適合性樹脂との混合を容易にするために、歯科材料に相溶化剤を添加してもよい。必要に応じて、歯科材料を適用する生体および/または歯科材料に隣接する組織の色調等に合わせて、歯科材料に着色剤を添加してもよい。
(5.改質処理)
また、本実施形態に係る歯科材料は、歯科材料の種類や用途、所要の特性等に応じて、必要に応じて、表面改質処理等の改質処理を施すことができる。例えば、歯科材料の表面の全体もしくは一部に親水性または疎水性の物質をコーティングするなどして、歯科材料の親水性/疎水性を調整することができる。
(6.特性)
本発明の歯科材料は、代表的には、以下の項目を指標として、その機械的特性、物理的特性、化学的特性、生物学的安定性、力学的安定性等を評価することができる。
通常の圧縮試験法、引張試験法に準拠し、対象の歯科材料に直線的な荷重を加えることによって、圧縮強さ(MPa)、引張強さ(MPa)および/または伸び(%)を測定する。本発明においては、圧縮強さは、対象の歯科材料の試料を、JIST6123、JIS T6501、JIS T6502、JIS T6503、JIS T6505、JIS T6506、JIS T6508、JIS T6509、JIST6512、JIST6513、JIS T6514、JIS T6515、JIS T6517、JIS T6518、JIS T6519、JIS T6520、JIST6521、JIS T6522、JIS T6523、JIS T6524、JIS T6525-1、JIS T6525-2、JIS T6527、JIS T6601、JIST6604、JIS T6605、JIS T6608、JIS T6609-1、JIS T6609-2、JIS T6610、JIS T6611、JIS T6612、JIST6003、JIS T6005、およびJIS K 7181から選択される1つ以上の規格に準拠して試験することによって得られる値とする。また、圧縮強さは、歯科材料の種類によらず同一の試験方法を適用してもよく、歯科材料の種類に応じて異なる試験方法を適用してもよい。
通常の試験法に準拠し、任意の試験機によって、対象の歯科材料の弾性率(GPa)および/または降伏値(MPa)を測定する。
JIS T6501等に準拠し、対象の歯科材料の曲げ強さ(MPa)および/または曲げ弾性率(MPa)を測定する。
一般に公知のシャルピー法、アイゾット法等により、対象の歯科材料の衝撃強さ(kgf・cm/cm)を測定する。
一般に公知の圧痕法、弾性法、引っかき法等により、対象の歯科材料のブリネル硬さ(HB)、ビッカース硬さ(Hv)、ヌープ硬さ(HK)、ショア硬さ等を測定する。
一般に公知のIM法、CSF法、CN法、SENB法等により、対象の歯科材料の破壊靱性(MN/m3/2)を測定する。
JIS T6506等に準拠し、対象の歯科材料の寸法試験を行う。
一般に公知の摩耗・摩擦試験機等により、対象の歯科材料の耐摩耗性を測定する。
通常の熱膨張試験法に準拠し、熱膨張試験機等によって、対象の歯科材料の線膨張係数(×10-6/℃)等を測定する。
一般に公知の酸・アルカリ溶解性試験等にしたがって、対象の歯科材料の酸・アルカリへの溶解性を測定する。
JIS T6501等に準拠し、対象の歯科材料の吸水率(%)を測定する。
対象の歯科材料の任意の断面について、電子顕微鏡観察によって気孔率(%)および/または気孔径(μm、nm)を測定する。
目視により、またはルーペ等を用いて、対象の歯科材料の外観を観察する。
JIS T6003に準拠し、対象の歯科材料の色調安定性を測定する。
ISO10993からの試験「医療機器の生物学的評価」、USP/USPクラスVIの生物学的試験等に準拠し、対象の歯科材料の生体適合性を試験する。
(7.歯科材料の具体的な例示)
次に、本発明の歯科材料のより具体的な実施形態として、インプラント材、補綴材、義歯材、充填材、義歯床材、成形修復材、印象材について説明する。
一実施形態において、本発明の歯科材料は、インプラント材、補綴材または義歯材であり、300MPa~400MPaの範囲内の圧縮強さを有する。本実施形態の一局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6123に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6501に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6502に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6503に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6505に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6506に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6508に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6509に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6512に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6513に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6514に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6515に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6517に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6518に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6519に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6520に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6521に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6522に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6523に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6524に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6525-1に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6525-2に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6527に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6601に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6604に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6605に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6608に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6609-1に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6609-2に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6610に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIST6611に準拠して試験することによって得られる。本実施形態の別の局面において、300MPa~400MPaの範囲内の圧縮強さは、JIS T6612に準拠して試験することによって得られる。
一実施形態において、本発明の歯科材料は、充填材であり、150MPa~250MPaの範囲内の圧縮強さを有する。本実施形態の一局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6123に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6501に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6502に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6503に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6505に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6506に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6508に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6509に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6512に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6513に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6514に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6515に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6517に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6518に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6519に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6520に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6521に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6522に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6523に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6524に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6525-1に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6525-2に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6527に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6601に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIST6604に準拠して試験することによって得られる。本実施形態の別の局面において、150MPa~250MPaの範囲内の圧縮強さは、JIS T6605に準拠して試験することによって得られる。
一実施形態において、本発明の歯科材料は、義歯床材であり、60MPa~100MPaの範囲内の圧縮強さを有する。本実施形態の一局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6123に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6501に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6502に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6503に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6505に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6506に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6508に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6509に準拠して試験することによって得られる。本実
施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6512に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6513に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6514に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6515に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6517に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6518に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6519に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6520に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6521に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6522に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6523に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6524に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6525-1に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6525-2に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6527に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6601に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6604に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6605に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6608に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6609-1に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6609-2に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6610に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6611に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6612に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS T6003に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIST6005に準拠して試験することによって得られる。本実施形態の別の局面において、60MPa~100MPaの範囲内の圧縮強さは、JIS K 7181に準拠して試験することによって得られる。より具体的には、例えば、本実施形態に係る義歯床材における60MPa~100MPaの範囲内の圧縮強さは、JIST6501に準拠して試験することによって得られる。
一実施形態において、本発明の歯科材料は、成形修復材であり、30MPa~50MPaの範囲内の圧縮強さを有する。本実施形態の一局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6123に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6501に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6502に準拠して試験することによって得られる。
形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6525-2に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6527に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6601に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6604に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6605に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6608に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6609-1に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6609-2に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6610に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6611に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6612に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6003に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6005に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JISK 7181に準拠して試験することによって得られる。より具体的には、例えば、本実施形態に係る成形修復材における30MPa~50MPaの範囲内の圧縮強さは、JIST6514に準拠して試験することによって得られる。また、本実施形態に係る成形修復材における30MPa~50MPaの範囲内の圧縮強さは、JIS T6515に準拠して試験することによって得られる。また、本実施形態に係る成形修復材における30MPa~50MPaの範囲内の圧縮強さは、JIST6522に準拠して試験することによって得られる。また、本実施形態に係る成形修復材における30MPa~50MPaの範囲内の圧縮強さは、JIS T6524に準拠して試験することによって得られる。
一実施形態において、本発明の歯科材料は、印象材であり、30MPa~50MPaの範囲内の圧縮強さを有する。本実施形態の一局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6123に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6501に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6502に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6503に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6505に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6506に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6508に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6509に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6512に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6513に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6514に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6515に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6517に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6518に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6519に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6520に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6521に準拠して試験することによって得られる。本実施形態の別の局面において
、30MPa~50MPaの範囲内の圧縮強さは、JIS T6522に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6523に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6524に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6525-1に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIS T6525-2に準拠して試験することによって得られる。本実施形態の別の局面において、30MPa~50MPaの範囲内の圧縮強さは、JIST6527に準拠して試験することによって得られる。
<歯科材料の製造方法>
本発明の歯科材料は、ナノファイバーと生体適合性樹脂とを所定の割合で混合(溶融混練)することによって作製される。混合方法としては、一般に公知の方法を適用することができる。例えば、一軸混練機または多軸混練機、ニーダー等を用いることができ、混合工程におけるナノファイバーと生体適合性樹脂との配合順序や溶融のタイミング等は特に限定されない。例えば、ナノファイバーと生体適合性樹脂とを溶融して混練してもよく、または、予め生体適合性樹脂を溶融しておき、混練時にナノファイバーを添加して混合してもよい。なお、抗菌物質およびその他の添加剤を配合する場合においても、その配合順序や溶融のタイミング等は、適宜調節することができる。混合温度は特に限定されず、ナノファイバーおよび生体適合性樹脂の種類や組み合わせ等に応じて適宜設定することができる。また、ナノファイバーと生体適合性樹脂との混合割合は、歯科材料の種類や用途、所要の特性等に応じて適宜調整することができる。
<B.歯科材料以外の応用>
本発明のナノファイバーと生体適合性材料を含む材料は、歯科材料のみならず、それ以外の用途においても優れている。上記<A.歯科材料>において説明した本発明のナノファイバーと生体適合性材料を含む材料は、歯科材料以外に、例えば、燃料棒のキャスクの強化のため、あるいは、放射線遮蔽物として、あるいは、車、船、宇宙船、宇宙基地、ロケット、航空機、または、モーターサイクルのボディの補強材として、あるいは、スペースデブリ破砕後接着材料として、あるいは、デブリバンパー宇宙船または宇宙基地の材料として、あるいは、ロボットフレームの材料として、あるいは、放射線遮蔽材料を含む屋根材として、あるいは、建築材料としても利用可能である。
ナノファイバーとしてセルロースナノファイバーを用い、生体適合性樹脂としてメタクリレートモノマーとポリメタクリレートとを用いて、ナノファイバーと生体適合性樹脂との質量比が85:15となるように水中に分散させ、よく攪拌した後、混練機に投入し、所定の温度で適切な時間溶融混練して、歯科材料を得る。
<実施例2>
ナノファイバーと生体適合性樹脂との質量比を83:17とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例3>
ナノファイバーと生体適合性樹脂との質量比を88:12とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例4>
ナノファイバーと生体適合性樹脂との質量比を80:20とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例5>
ナノファイバーと生体適合性樹脂との質量比を75:25とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例6>
ナノファイバーとして、セルロースナノファイバーと炭酸カルシウムとの複合体を用いること以外は実施例1と同様にして、歯科材料を得る。
<実施例7>
ナノファイバーとして、セルロースナノファイバーとキトサンナノファイバーとを質量比で90:10の割合で混合したものを用いること以外は実施例1と同様にして、歯科材料を得る。
<実施例8>
ナノファイバーおよび生体適合性樹脂に加えて、抗菌物質として銅イオンを内包したマイクロカプセルを用い、質量比が85:13:2となるように配合すること以外は実施例1と同様にして、歯科材料を得る。
<実施例9>
ナノファイバーと生体適合性樹脂との質量比を65:35とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例10>
ナノファイバーと生体適合性樹脂との質量比を50:50とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例11>
ナノファイバーと生体適合性樹脂との質量比を30:70とすること以外は実施例1と同様にして、歯科材料を得る。
<実施例12>
ナノファイバーと生体適合性樹脂との質量比を20:80とすること以外は実施例1と同様にして、歯科材料を得る。
Claims (17)
- ナノファイバーと生体適合性樹脂とを含む歯科材料。
- 前記ナノファイバーが、セルロースナノファイバーである、請求項1に記載の歯科材料。
- 前記ナノファイバーが、キトサンナノファイバーおよびキチンナノファイバーのうちの一種以上をさらに含む、請求項2に記載の歯科材料。
- 前記歯科材料が抗菌物質を含む、請求項1から3のうちのいずれか一項に記載の歯科材料。
- 前記歯科材料が、インプラント材、補綴材、義歯材、充填材、義歯床材、成形修復材または印象材である、請求項1から4のうちのいずれか一項に記載の歯科材料。
- 前記歯科材料がインプラント材、補綴材または義歯材であり、300MPa~400MPaの範囲内の圧縮強さを有する、請求項5に記載の歯科材料。
- 前記歯科材料が充填材であり、150MPa~250MPaの範囲内の圧縮強さを有する、請求項5に記載の歯科材料。
- 前記歯科材料が義歯床材であり、60MPa~100MPaの範囲内の圧縮強さを有する、請求項5に記載の歯科材料。
- 前記歯科材料が成形修復材または印象材であり、30MPa~50MPaの範囲内の圧縮強さを有する、請求項5に記載の歯科材料。
- 前記圧縮強さが、JIS T6123、JIS T6501、JIS T6502、JIS T6503、JIS T6505、JIS T6506、JIS T6508、JIST6509、JIS T6512、JIS T6513、JIS T6514、JIS T6515、JIS T6517、JIS T6518、JIS T6519、JIST6520、JIS T6521、JIS T6522、JIS T6523、JIS T6524、JIS T6525-1、JIS T6525-2、JIS T6527、JIST6601、JIS T6604、JIS T6605、JIS T6608、JIS T6609-1、JIS T6609-2、JIS T6610、JIS T6611、JIST6612、JIS T6003、JIS T6005、およびJIS K 7181から選択される1つ以上の規格に準拠して試験することによって得られる、請求項6~9のうちのいずれか一項に記載の歯科材料。
- ナノファイバーと樹脂とを含む材料であって、さらに、
(1)コーティング剤、ならびに
(2)鉛、タングステン、ホウ素、グラファイト、グラフェン、およびカドミニウムからなる群から選択される添加剤
からなる群から選択される物質をさらに含む材料。 - 請求項11に記載の材料であって、燃料棒のキャスクの強化のため、あるいは、放射線遮蔽物として、あるいは、車、船、宇宙船、宇宙基地、ロケット、航空機、または、モーターサイクルのボディの補強材として、あるいは、スペースデブリ破砕後接着材料として、あるいは、デブリバンパー宇宙船または宇宙基地の材料として、あるいは、ロボットフレームの材料として、あるいは、放射線遮蔽材料を含む屋根材として、あるいは、建築材料として使用するための、材料。
- 前記ナノファイバーが、セルロースナノファイバーである、請求項11に記載の材料。
- 前記樹脂が、メチルメタクリレート(MMA)、ポリメチルメタクリレート(PMMA)、2-ヒドロキシエチルメタクリレート(HEMA)、トリ-n-ブチルボラン(TBB)、および、4-メタクリロキシエチルトリメリテートアンハイドライド(4-META)からなる群から選択される、請求項11に記載の材料。
- 前記コーティング剤が、ポリウレアである、請求項11に記載の材料。
- 1GPa~3GPaの範囲内の圧縮強さを有する、請求項11~15のいずれか一項に記載の材料。
- 前記圧縮強さが、JIS A1106:2006、JIS A1107;2012、JIS A1108;2006、JIS A1113:2006、JISA1114;2011、JIS A1132;2014、JIS A1136;1993、JIS A1142;2007、JIS D4610:1993、JISH7701:2008、JIS R3222;2003、JIS S1200;2012、JIS S1203;1998、JIS S1205;1998、JISZ8841;1;1993、AST MD953-95、ISO/TS20746:2016、ISO 75-3:2004、ISO 1752020:2016、ISO1920-4;2005、ISO 1920-5:2004、ISO 2633:1974、ISO 3185:2008、ISO 3186:2008、ISO3193;2008,、ISO-3202:1997、ISO-3203;1993、ISO-7689;2008、ISO-8168;2016、ISO-5856;2008、ISO-5857;2008、ISO-7173;1989、ISO-7176;8;2014、ISO-9152;1998、ISO-9154;2016、ISO-9254:1993、ISO-9255;2008、ISO-9256;1993、ISO-9709;2005、ISO-9845-1;1992、ISO-12258;1998、ISO-12260;2016、ISO-12261;2016、ISO-1391;2008から選択される1つ以上の規格に準拠して試験することによって得られる、請求項16に記載の歯科材料。
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EP17760098.8A EP3424485A4 (en) | 2016-03-01 | 2017-03-01 | DENTAL MATERIAL |
KR1020187026269A KR20180114917A (ko) | 2016-03-01 | 2017-03-01 | 치과 재료 |
AU2017226654A AU2017226654A1 (en) | 2016-03-01 | 2017-03-01 | Dental material |
CA3016113A CA3016113A1 (en) | 2016-03-01 | 2017-03-01 | Dental material |
US16/080,916 US20190125632A1 (en) | 2016-03-01 | 2017-03-01 | Dental material |
JP2018503382A JPWO2017150634A1 (ja) | 2016-03-01 | 2017-03-01 | 歯科材料 |
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JP (1) | JPWO2017150634A1 (ja) |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0238402A (ja) * | 1988-06-10 | 1990-02-07 | Bayer Ag | 充填剤を含有する重合可能な物質およびその使用 |
JP2006001910A (ja) * | 2004-06-21 | 2006-01-05 | Kazunori Kusano | 歯科用根管充填材および歯科用糊剤 |
JP2006510763A (ja) * | 2002-12-19 | 2006-03-30 | ランクセス ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング | カーボンブラックおよびカーボンナノファイバーを含有する導電性の熱可塑性樹脂 |
JP2007332040A (ja) * | 2006-06-12 | 2007-12-27 | Shinshu Univ | カーボンナノチューブを含む抗菌剤とそれを用いた材料及び製剤 |
JP2013095665A (ja) * | 2011-10-27 | 2013-05-20 | Tokuyama Dental Corp | 歯科用アルジネート印象材組成物 |
JP2013535532A (ja) * | 2010-07-14 | 2013-09-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリ | ポリマー複合体およびその作製 |
WO2016043145A1 (ja) * | 2014-09-17 | 2016-03-24 | 国立大学法人名古屋大学 | 導電性組成物及びその製造方法 |
JP2016193876A (ja) * | 2015-03-31 | 2016-11-17 | 株式会社松風 | 医科歯科用硬化性組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2751939B2 (ja) * | 1989-10-19 | 1998-05-18 | 宣男 中林 | 移植用材料およびその製造方法 |
CN101884599B (zh) * | 2010-07-09 | 2012-11-28 | 武汉高登齿科材料有限公司 | 一种正畸用可见光固化胶粘剂及其制备方法 |
KR101370023B1 (ko) * | 2012-04-06 | 2014-03-06 | 서울대학교산학협력단 | 합성고분자 나노섬유메시와 mta를 포함하는 치수질환 치료용 조성물 |
GB201313898D0 (en) * | 2013-08-02 | 2013-09-18 | Bradford | Formulations and materials with cationic polymers |
CN103622837B (zh) * | 2013-12-02 | 2016-04-06 | 上海纳米技术及应用国家工程研究中心有限公司 | 自酸蚀双亲性齿科粘结剂及其制备方法 |
-
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0238402A (ja) * | 1988-06-10 | 1990-02-07 | Bayer Ag | 充填剤を含有する重合可能な物質およびその使用 |
JP2006510763A (ja) * | 2002-12-19 | 2006-03-30 | ランクセス ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング | カーボンブラックおよびカーボンナノファイバーを含有する導電性の熱可塑性樹脂 |
JP2006001910A (ja) * | 2004-06-21 | 2006-01-05 | Kazunori Kusano | 歯科用根管充填材および歯科用糊剤 |
JP2007332040A (ja) * | 2006-06-12 | 2007-12-27 | Shinshu Univ | カーボンナノチューブを含む抗菌剤とそれを用いた材料及び製剤 |
JP2013535532A (ja) * | 2010-07-14 | 2013-09-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリ | ポリマー複合体およびその作製 |
JP2013095665A (ja) * | 2011-10-27 | 2013-05-20 | Tokuyama Dental Corp | 歯科用アルジネート印象材組成物 |
WO2016043145A1 (ja) * | 2014-09-17 | 2016-03-24 | 国立大学法人名古屋大学 | 導電性組成物及びその製造方法 |
JP2016193876A (ja) * | 2015-03-31 | 2016-11-17 | 株式会社松風 | 医科歯科用硬化性組成物 |
Non-Patent Citations (4)
Title |
---|
See also references of EP3424485A4 * |
SILVA,RAFAEL.M ET AL.: "Dental glass ionomer cement reinforced by cellulose microfibers and cellulose nanocrystals", MATERIALS SCIENCE AND ENGINEERING C, vol. 58, 29 August 2015 (2015-08-29), pages 389 - 395, XP055414982 * |
SUN,WEI ET AL.: "Post-draw PAN-PMMA nanofiber reinforced and toughened Bis-GMA dental restorative composite", DENTAL MATERIALS, vol. 26, no. 9, 2010, pages 873 - 880, XP055414979 * |
UYAR,TANSEL ET AL.: "Electrospun nanofiber reinforcement of dental composites with electromagnetic alignment approach", MATERIALS SCIENCE AND ENGINEERING C, vol. 62, 4 February 2016 (2016-02-04), pages 762 - 770, XP029452966 * |
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EP3424485A1 (en) | 2019-01-09 |
JPWO2017150634A1 (ja) | 2019-02-07 |
CA3016113A1 (en) | 2017-09-08 |
KR20180114917A (ko) | 2018-10-19 |
AU2017226654A1 (en) | 2018-09-20 |
US20190125632A1 (en) | 2019-05-02 |
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