WO2017146561A1 - Supplément diététique pour améliorer la fixation de nutriments et augmenter la masse musculaire - Google Patents

Supplément diététique pour améliorer la fixation de nutriments et augmenter la masse musculaire Download PDF

Info

Publication number
WO2017146561A1
WO2017146561A1 PCT/MX2016/000020 MX2016000020W WO2017146561A1 WO 2017146561 A1 WO2017146561 A1 WO 2017146561A1 MX 2016000020 W MX2016000020 W MX 2016000020W WO 2017146561 A1 WO2017146561 A1 WO 2017146561A1
Authority
WO
WIPO (PCT)
Prior art keywords
supplement
amount
muscle
presentation
amino acids
Prior art date
Application number
PCT/MX2016/000020
Other languages
English (en)
Spanish (es)
Inventor
Francisco Elías ARROYO PAZ
Original Assignee
Arroyo Paz Francisco Elías
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arroyo Paz Francisco Elías filed Critical Arroyo Paz Francisco Elías
Publication of WO2017146561A1 publication Critical patent/WO2017146561A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Definitions

  • the present invention relates to the technical field of nutrition, food technology and medicine; since it provides a dietary supplement that improves the fixation of nutrients helping to increase muscle mass.
  • Muscle Mass is the volume of total body tissue that corresponds to muscle. There are three types of muscle, the heart muscle that is part of the heart, the smooth muscle that is found in the viscera and the skeletal muscle whose main function is to carry out the different movements and maintain the posture of the body.
  • Muscular hypertrophy is the scientific name given to the phenomenon of growth in the size of muscle cells, that is, the increase in size of muscle fibers and therefore muscle. Technically it is the growth of muscle cells without a cell division, the muscle subjected to this change also offers a better response to the load. This phenomenon is usually found in the muscles of those athletes who practice anaerobic sports in which they repeat successively the same exercise, such as, for example: bodybuilding, weightlifting and fitness, among others.
  • hypertrophy can be seen as a synthesis of proteins, a cessation of degradation or a combination of both processes.
  • protein synthesis grows at a rate of 112%, 65% and 34% after having spent 3 hours, 24 and 48 of the exercise.
  • breaking of peptide bonds protein oxidation
  • Amino acid transport plays a very important role in protein synthesis, some authors have been able to verify that the transport of amino acids is increased three hours after intense exercise.
  • muscle hypertrophy There are different types of muscle hypertrophy:
  • Physiological muscle hypertrophy It is the result of training and sports practice in bodybuilding and sports in which muscle development is needed. It aims exclusively at muscle growth.
  • the method consists of lifting weights focusing on some muscles as an objective, in this case it is tested with a large weight that is known for sure only one lift can be done until you reach complete muscular fatigue, then the weight size is lowered until four repetitions can be done. If the training is repeated during a season the muscles are conditioned to work at this intensity and repetitions of 6 or 8 can soon be done, if the weight is increased so that it is retrained and this operation is continued, the muscle that Work begins to hypertrophy. This type of training must be monitored by a sports coach since the effort that is made can overcome the resistance of the tendons leading to consequent muscle and bone injuries.
  • Muscle hypertrophy due to the use of asteroids It is the muscular hypertrophy caused by hormonal stimulation due to the intake of anabolics that is considered as a doping, with the risk to the user of suffering numerous side effects such as interference in genital growth and development , if consumed during adolescence, masculinity in women, atrophy testicular in men, as well as changes in libido and decreased reproductive capacity, heart failure and heart attacks, hypomania (pathological elevation of mood and exaggerated need to be active) and tendency to aggressiveness, increased risk of injury Musculotendinous and reproductive system cancer, fluid retention and high blood pressure. 3.
  • Pathological muscular hypertrophy It is the muscular hypertrophy that occurs as a characteristic sign of diseases such as ventricular hypertrophy, hypertrophic pyloric stenosis, in Kocher syndrome and Thomsen hypertrophic congenital myotonia.
  • the liposomes are used in the lumen of the active compound (s) to be installed.
  • the preparation of the liposomes is carried out by conventional methods described in the literature.
  • the agent is a substance that increases the effectiveness of the active compound (s).
  • Said substance is, for example, a hormone such as insulin, insulin-like growth factor, a vitamin, a nutrient such as glucose or amino acid, or an ordinary muscle building drug, such as an Anabolsteroid.
  • the means of the product are to maintain the muscular performance and body cell mass of a human being, as well as the animal body and / or to increase possible, regardless of whether it is sick or healthy.
  • the product contains calcium which can be whey or a composition containing whey, derived whey protein product, whey mineral derived from isolating mixtures, or combinations thereof, any of which may optionally include enzymes.
  • intrinsic or additional inhibitory peptides such as angiotensin-converting enzyme (ACE) inhibit peptides.
  • ACE angiotensin-converting enzyme
  • the application describes that whey products can be damaged in several stages, for example, manufacturing, storage or shipping. Desirable characteristics of fresh whey may include whey leucine or branched amino acid content, which is higher than the casein fraction of milk. He says that the product is effective when accompanied by a good diet.
  • the present invention provides a dietary supplement that allows improving nutrient fixation by helping to increase muscle mass comprising:
  • Creatine is an anabolic that is currently used as a dietary supplement in some intensity sports, due to its ergogenic properties and allows repetitive loads and short recovery periods, with the aim of gaining anaerobic energy. Creatine is naturally produced in the human body from amino acids primarily in the kidney and liver. It is transported in the blood for muscle use. Approximately 95% of the total creatine in the human body is found in the muscle skeletal. Creatine is not an essential nutrient, since it is biosynthesized in the human body from L-arginine, glycine and L-methionine. In humans and animals, approximately half of the stored creatine is consumed from food (especially from meat).
  • Creatine is 100% natural and is naturally present in many foods, therefore, it can never be banned in any sport or international competitions. Many foods, especially herring, salmon, tuna and beef contain some creatine. However, the best source of creatine at the moment is creatine monohydrate, as it contains more creatine per product weight than any other source. Creatine is not marketed in its purest form due to the instability it offers and for this reason it is common to find it as a monohydrate: "creatine monohydrate", which is a creatine molecule attached to a water molecule.
  • Creatine Monohydrate in the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass, are:
  • creatine supplementation should not be used by people with pre-existing kidney disease, or those with potential risk for renal dysfunction (Diabetes, Hypertension, Reduction in glomerular filtration rate).
  • HMB Hydroxy Beta Methylbutyrate
  • HMB is not an essential nutrient, so there is no specific requirement. HMB is found in small amounts in citrus fruits and catfish. However, to obtain a therapeutic dose you need to consume a supplement in the form of powder or pills.
  • HMB can improve the response to weightlifting.
  • a small, double-blind, placebo-controlled clinical trial found evidence that HMB could help prevent muscle damage during prolonged exercise, therefore potentially increasing recovery during physical training.
  • HMB Hydroxy Beta Methylbutyrate
  • Whey protein is a product composed mainly of globular proteins of high biological value extracted from whey, a resulting liquid milk as a by-product during the production of some cheeses. It is generally marketed and used as a dietary supplement for sports activity, especially with the aim of developing strength or increasing muscle mass. Some preclinical studies in rodents have suggested that whey protein may possess anti-inflammatory or anti-cancer properties, however, human data is scarce. The effects of whey protein on human health are of great interest and are being investigated as a way to reduce the risk of diseases, as well as possible complementary treatment for various diseases. Although whey protein is responsible for some Milk allergies, the main allergen in milk is casein.
  • Whey stays when the milk coagulates during the cheese production process, and contains everything that is soluble in the milk after the pH is reduced to 4.6 during the coagulation process. It is a 5% solution of lactose in water, with some minerals and albumin lacto.
  • the fat is removed and then processed for human consumption. The processing can be done by simple drying, or the protein content can be increased by removing lipids and other non-protein materials.
  • the serum can be denatured by high temperatures. Raising the temperature (high and sustained temperatures above 72 ° C associated with the pasteurization process) denatures whey proteins.
  • the whey protein fraction is approximately 10% of the weight and comprises four main types of proteins.
  • whey protein within the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass, are: - Give rise to a larger area of muscle section when combined with resistance training.
  • Leucine is one of the twenty amino acids that cells use to synthesize proteins; It is one of the essential amino acids that we have to contribute to our body through diet, being unable to synthesize it. As a dietary supplement, leucine has been found to reduce muscle tissue degradation by increasing the synthesis of muscle proteins in old rats. Leucine does not act as a carbon source for glucose synthesis as it is ketogenic and non-glycogenic. It has the ability to mimic insulin and help sugar get into cells. It can also replace glucose during periods of fasting, a unique property compared to other amino acids. In other words, Leucine improves glucose and insulin homeostasis by stabilizing blood glucose levels. Leucine is altered during aging, which causes an imbalance in the breakdown and production of muscle proteins; reason for which a loss of muscular mass in the elderly people originates.
  • Leucine in the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass, are:
  • L-arginine is a fundamental chemical block called "amino acid.” L-arginine is found in red meat, in poultry and dairy products, it can also be made in the laboratory and used as a medicine. L-arginine is used for conditions of the heart and blood vessels including congestive heart failure (CHF), chest pain, high blood pressure and coronary artery disease. L-arginine is also used for recurrent pain in the legs due to arteries that are blocked, for the treatment of decreased mental capacity in the elderly, for erectile dysfunction and male infertility.
  • CHF congestive heart failure
  • L-arginine is also used for recurrent pain in the legs due to arteries that are blocked, for the treatment of decreased mental capacity in the elderly, for erectile dysfunction and male infertility.
  • L-arginine for the prevention of the common cold, to improve the functioning of the kidneys after a kidney transplant, for high blood pressure during pregnancy, to improve athletic performance, to increase the immune system and to prevent inflammation of the digestive tract in premature infants.
  • L-arginine is used in combination with a large number of medications that are sold with or without a prescription and that are used for different conditions.
  • L-arginine is used together with ibuprofen for migraine headaches; together with the conventional drugs used in chemotherapy treatments for breast cancer; together with other amino acids for the treatment of weight loss in patients with AIDS; and together with fish oil and other supplements to reduce infections, improve wound healing and shorten the time needed for recovery after surgery.
  • L-arginine to the skin to accelerate wound healing and to increase blood flow to frozen hands and feet, especially in people with diabetes. It is also used as a cream for sexual problems in both men and women.
  • the main functions of L-Arginine within the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass, are:
  • Lysine is an amino acid component of proteins synthesized by living things. It is one of the 10 essential amino acids for humans.
  • This amino group in addition to providing a positive charge to proteins, is acetylable by specific enzymes, known as acetyltransferases; This acetylation is considered to be a post-translational modification, since it occurs after the translation of the protein from the messenger RNA.
  • Collagen contains hydroxylysine, which is derived from lysine through lysyl hydroxylase. The 0-glycosylation of lysine residues in the endoplasmic reticulum or in the Golgi apparatus is used to label certain proteins for cell secretion.
  • Lysine is a necessary element for the construction of all body proteins; plays a central role in calcium absorption; in the construction of muscle proteins; in the recovery of surgical interventions or sports injuries, and in the production of hormones, enzymes and antibodies.
  • Lysine within the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass, are:
  • Branched Chain Amino Acids refers to a type of amino acid that has an aliphatic compound that is nonlinear, its name comes from this branched characteristic. Among them are leucine, isoleucine and valine; the combination of these three Essential amino acids make up almost a third of the skeletal muscles in the human body and play a very important role in protein synthesis. Branched-chain amino acids are frequently used in the treatments of patients who have suffered burns, as well as in the dietary supplements of athletes who practice bodybuilding.
  • Branched Chain Amino Acids One of the main functions of this type of amino acid is protein synthesis.
  • the oxidation of Branched Chain Amino Acids has the function of providing metabolic energy to the muscles, as well as to other organs that request it, they are precursors of the synthesis of amino acids, being a promoter of the synthesis of alanine and glutamine in the states.
  • catabolic The catabolism wears the skeletal muscle generating a negative nitrogen balance in the tissues.
  • Branched Chain Amino Acids stop proteolysis in both living subjects and laboratory samples. This type of amino acid is captured by the muscle causing certain ergogenic effects, mainly stopping the catabolic effect and favoring protein synthesis.
  • the content of branched chain amino acids increases during the first phases of the exercise and subsequently decreases; the rate or rate of decline depends directly on the intensity of the exercise; They usually increase serotonin levels when the brain receives elevated tryptophan levels.
  • Branched Chain Amino Acids are used in the body as regulators of protein synthesis and degradation and are key precursors in the synthesis of glutamine and alanine.
  • the oxidation of Branched Chain Amino Acids generates anaerobic energy in the muscles;
  • the oxidation of Branched Chain Amino Acids is controlled in the short term by products synthesized in the transamination of leucine and in the long term by many physiological and pathological conditions such as diabetes, cancer, sepsis and infection.
  • the Branched Chain Amino Acids used in the dietary supplement that allows to improve the fixation of nutrients, helping to increase muscle mass, are:
  • the concentration of the components of the dietary supplement that allows to improve the fixation of nutrients helping to increase muscle mass are: i. CREATINE MONOHIDRATE from 5 to 8%;
  • the concentration of the Branched Chain Amino Acids present in the dietary supplement that allows to improve the fixation of nutrients, helping to increase muscle mass are concentrated as follows:
  • the dietary supplement that improves the fixation of nutrients by helping to increase muscle mass can be in usual forms, such as solution, suspension, emulsion, powder, tablet, capsule, solid, liquid or ointment.
  • Example 1 Elaboration of 1,000 grams of the dietary supplement that allows to improve the fixation of the nutrients helping to increase the muscular mass, reason of the present invention.
  • the components are mixed with the following amounts:

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention se rapporte au domaine technique de la nutrition, de la technologie des aliments et de la médecine et concerne un supplément diététique qui permet d'améliorer la fixation des nutriments favorisant l'augmentation de la masse musculaire, lequel supplément diététique peut être consommé par des sportifs de sorte que ces derniers n'aient pas d'inquiétude puisque leur consommation apporte la sécurité que les ingrédients contenus se trouvent dans un dosage adéquat et surtout, sont dépourvus d'agents contaminants, de produits pharmaceutiques ou de substances (drogues) interdites, afin d'éviter les répercussions sur la santé ou la performance du sportif, et éviter également les problèmes liés au test antidopage.
PCT/MX2016/000020 2016-02-23 2016-02-23 Supplément diététique pour améliorer la fixation de nutriments et augmenter la masse musculaire WO2017146561A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2016/002358 2016-02-23
MX2016002358A MX2016002358A (es) 2016-02-23 2016-02-23 Suplemento dietético para mejorar la fijación de nutrimento e incrementar la masa muscular.

Publications (1)

Publication Number Publication Date
WO2017146561A1 true WO2017146561A1 (fr) 2017-08-31

Family

ID=59685682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2016/000020 WO2017146561A1 (fr) 2016-02-23 2016-02-23 Supplément diététique pour améliorer la fixation de nutriments et augmenter la masse musculaire

Country Status (2)

Country Link
MX (1) MX2016002358A (fr)
WO (1) WO2017146561A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010008641A1 (en) * 1998-11-25 2001-07-19 R. Douglas Krotzer Nutritionally active composition for bodybuilding
CN104543984A (zh) * 2013-10-16 2015-04-29 戴留庆 一种氨基酸组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010008641A1 (en) * 1998-11-25 2001-07-19 R. Douglas Krotzer Nutritionally active composition for bodybuilding
CN104543984A (zh) * 2013-10-16 2015-04-29 戴留庆 一种氨基酸组合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI 30 August 2016 Derwent World Patents Index; AN 2015-39213X, XP055413265 *
FIELD A E ET AL.: "Exposure to the mass media, body shape concerns, and use of supplements to improve weight and shape among male and female adolescents", PEDIATRICS, vol. 116, no. 2, 30 November 2004 (2004-11-30), pages e214 - e220, XP055413267, ISSN: 0031-4005 *
PIEKARSKA A ET AL.: "Modern anabolics and anticatabolics: The scope of the hepatologist's knowledge", EXPERIMENTAL AND CLINICAL HEPATOLOGY 2009 MEDICAL SCIENCE INTERNATIONAL POL, vol. 5, no. 1, 1 March 2009 (2009-03-01), pages 7 - 11, XP055413261, ISSN: 1734-3038 *

Also Published As

Publication number Publication date
MX2016002358A (es) 2017-08-22

Similar Documents

Publication Publication Date Title
ES2780573T3 (es) Composición alimenticia que contiene aminoácidos y cacao
AU2013392167B2 (en) Muscle preservation in overweight or obese adult during weight loss program
JP2012533627A (ja) 機能状態の喪失を減弱する方法
KR20200039748A (ko) 간 질환 치료를 위한 아미노산 조성물
JP2005501061A (ja) 免疫機能損傷患者の為の栄養療法
JP2012197283A (ja) シトルリンを使用する治療
US7740878B2 (en) Use of betaine to enhance exercise performance
JP2014534203A (ja) 筋委縮症及び筋肉減少症に対抗する乳清タンパク質ミセル
ES2668885T3 (es) Combinación de beta-hidroxi beta-metilbutírico, arginina, y glutamina para su uso en el tratamiento de úlceras diabéticas
US6203820B1 (en) Compositions and methods for enhancing protein anabolism and detoxification
Bouillanne et al. Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: A randomized controlled trial
JP6435079B1 (ja) 体内ｂｄｎｆ量増加促進用組成物
JPS63501214A (ja) 異化機能障害の治療方法
JPS63287462A (ja) ペプチド栄養剤
US20150216779A1 (en) Compositions for targeted anti-aging therapy
KR20050071562A (ko) 글루타민을 제공하기 위한 방법 및 조성물
CN103269697A (zh) 半胱氨酸和食物摄入
ES2857652T3 (es) Principio activo para el tratamiento de la sarcopenia
ES2815351T3 (es) Péptidos marinos y nucleótidos de pescado, composiciones y sus usos para reducir la glucosa en sangre
CN103478718B (zh) 提高人体内谷胱甘肽浓度的功能食品及其制备方法
WO2017146561A1 (fr) Supplément diététique pour améliorer la fixation de nutriments et augmenter la masse musculaire
FR3027491A1 (fr) Composition comprenant des proteines vegetales et utilisation pour la prevention des pathologies metaboliques et cardiovasculaires associees au risque cardiometabolique en particulier avec hyperglycemie
ES2260500T3 (es) Productos alimenticios ricos en mentionina modificados y procesos para su fabricacion.
WO2013009194A1 (fr) Complément alimentaire de haute valeur immunologique à base de matrice protéique
CA3216989A1 (fr) Compositions nutritionnelles pour la conservation de la masse musculaire

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16891775

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 16891775

Country of ref document: EP

Kind code of ref document: A1