WO2017119742A1 - Appareil monté sur un masque facial, et masque facial et kit comprenant celui-ci - Google Patents

Appareil monté sur un masque facial, et masque facial et kit comprenant celui-ci Download PDF

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Publication number
WO2017119742A1
WO2017119742A1 PCT/KR2017/000151 KR2017000151W WO2017119742A1 WO 2017119742 A1 WO2017119742 A1 WO 2017119742A1 KR 2017000151 W KR2017000151 W KR 2017000151W WO 2017119742 A1 WO2017119742 A1 WO 2017119742A1
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WO
WIPO (PCT)
Prior art keywords
electrolyte
battery
sheet
mask pack
exchange membrane
Prior art date
Application number
PCT/KR2017/000151
Other languages
English (en)
Korean (ko)
Inventor
장명훈
이준
박은진
이선형
이창주
탁찬유
강성구
Original Assignee
바이오센서연구소 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160072695A external-priority patent/KR20170082111A/ko
Application filed by 바이오센서연구소 주식회사 filed Critical 바이오센서연구소 주식회사
Priority to US15/777,410 priority Critical patent/US10945516B2/en
Priority to CN201780005802.3A priority patent/CN108601935B/zh
Priority to SG11201703910UA priority patent/SG11201703910UA/en
Priority to JP2018536198A priority patent/JP6641015B2/ja
Publication of WO2017119742A1 publication Critical patent/WO2017119742A1/fr

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    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose

Definitions

  • the sheet mask pack is a product that can be moisturized and cleansed by applying a sheet type made in the form of a face without applying by hand, and is designed to cover the entire face. It is available on the market in various forms, including sheets divided into two sheets, and sheets tailored to specific areas such as eyes, eyes and mouth.
  • General mask packs are locally transdermally delivered to a bioactive material, and thus, there is a limit to the delivery of useful substances to the skin.
  • In order to transfer useful substances to the skin using the mask pack it is important to make the mask pack adhere well to the skin.
  • various attempts have been made to further enhance the cosmetic effect, one of which is the use of an iontophoresis device.
  • Iontophoresis is a drug delivery method that allows charged molecules to pass through tissue easily.
  • 1 is a view schematically showing a conventional iontophoresis device.
  • an iontophoresis device is a technique of infiltrating an ionic substance into skin using a direct current, and includes an ionic substance having a positive characteristic in order to use a repulsive force acting between ions of the same polarity. It is applied to the + 'electrode, and the ionic material having negative characteristics is applied to the'-'electrode so that the ionic material easily penetrates the skin.
  • iontophoresis devices provide active transport in the electric field.
  • the conventional iontophoresis device has a problem that itching, pain, burning, erythema, etc. occur in the skin of the user using the iontophoresis device because the oxidation reaction is generated on the surface of the electrode attached to the skin.
  • the mask pack adheres well to the skin, the delivery of the bioactive substance through the skin is improved, and the specific portion of the bioactive substance can be specifically delivered to a desired area, for example, a wrinkled area.
  • a device that is mounted on a mask pack that can prevent side effects that may occur in the process of delivering a useful material to the skin using a battery having an electrode, and a mask pack comprising the same.
  • the technical problem to be achieved by the present embodiment is not limited to the technical problems as described above, and further technical problems can be inferred from the following embodiments.
  • One aspect is a device mounted on the mask pack, comprising: a battery unit having a negative electrode and a positive electrode; And an intermediate intermediate sheet electrically connected to the battery unit, wherein the intermediate intermediate sheet is configured to allow a current generated from the battery unit to flow into the material-containing sheet of the mask pack.
  • Another aspect is the apparatus; And it is to provide a mask pack comprising an intermediate sheet of the device is a sheet containing a material connected to the opposite side of the surface connected to the battery unit.
  • Yet another aspect is to provide a kit comprising the device, or the mask pack, and a container containing an aqueous solution for activating the device.
  • the mask pack is well adhered to an application site, for example, the skin, and the delivery of the bioactive substance through the skin is improved, It is effective to prevent itching, pain, burning, and erythema that may occur in the process of delivering the bioactive substance to the skin using the device provided.
  • FIG. 1 is a view schematically showing a conventional iontophoresis device.
  • FIG. 2 is a diagram schematically showing an apparatus mounted on a mask pack according to one embodiment.
  • FIG 3 is a diagram schematically illustrating an upper surface of a mask pack according to one embodiment.
  • FIG. 4 is a diagram schematically illustrating a perspective view of a mask pack according to one embodiment.
  • FIG. 5 is a diagram schematically showing a perspective view of a mask pack according to another embodiment.
  • FIG. 6 is a diagram showing the side of the mask pack using a reverse electrodialysis battery according to an embodiment.
  • FIG. 7 is a diagram schematically illustrating an activation principle of a mask pack using a reverse electrodialysis battery according to one embodiment
  • 7C shows the electrolyte flow of the reverse electrodialysis cell in the activated state.
  • FIG. 8 is a photograph of a device mounted on a mask pack manufactured according to one embodiment.
  • FIG. 9 is a view showing the container of the battery unit of the device mounted on the mask pack according to one embodiment.
  • FIG. 10 is a photograph showing that the mask pack prepared according to one embodiment is applied to pig skin divided into a control group (left panel) and an experimental group (right panel).
  • FIG. 11 is a photograph showing the mass transfer effect when the mask pack prepared according to one embodiment is applied to pig skin.
  • FIG. 12 is a graph quantitatively illustrating a mass transfer effect when a mask pack prepared according to one embodiment is applied to pig skin.
  • Figure 13 is a graph showing the vitamin C delivery effect when the mask pack prepared according to one embodiment applied to the mouse skin.
  • a part when a part is connected to another part, it includes not only a case where the part is directly connected, but also an electric part connected between other components in between. .
  • a part when a part includes a certain component, this means that the component may further include other components, not to exclude other components unless specifically stated otherwise.
  • the terms "... unit”, “... module” described in the embodiments means a unit for processing at least one function or operation, which is implemented in hardware or software, or a combination of hardware and software. Can be implemented.
  • One aspect provides an apparatus mounted to a mask pack.
  • FIG. 2 is a diagram schematically illustrating an apparatus 101 mounted on a mask pack according to one embodiment.
  • the device mounted on the mask pack includes a battery unit 110 having a cathode and an anode; And an intermediate intermediate sheet 116 electrically connected to the battery unit 110.
  • the battery unit 110 may use any battery that can generate a current.
  • the battery unit may include a reverse electrodialysis battery, a primary battery, or a secondary battery, and in detail, a flexible battery, an alkaline battery, a battery, a mercury battery, a lithium battery, nickel-cadmium A battery, a nickel-hydrogen battery, a lithium ion secondary battery, and a lithium ion polymer secondary battery may include any one selected from the group consisting of a battery.
  • the reverse electrodialysis battery will be described in detail with reference to FIGS. 6 and 7.
  • the battery unit 110 may be located at any part of one surface of the intermediate media sheet 116.
  • the battery unit 110 may include an electrode, and each of the electrodes, ie, the negative electrode 131 and the positive electrode 132, is connected to the intermediate media sheet 116 by the connecting portions 118 and 119 of the intermediate media sheet 116. And may be electrically connected with.
  • Materials that can be used as the electrode may include a conductive material, for example, silver, silver epoxy, palladium, copper, aluminum, gold, titanium, palladium, chromium, nickel, platinum, silver / silver chloride, silver / Silver ions or mercury / mercury oxide.
  • the intermediate medium sheet 116 may be configured to allow the current generated from the battery unit 110 to flow to the material-containing sheet 120 of the mask pack.
  • the intermediate sheet 116 partially includes an insulating portion, and the current generated from the negative electrode 131 and the positive electrode 132 of the battery is not electrically connected by the insulating portion of the intermediate intermediate sheet 116. It may not be.
  • the intermediate media sheet 116 may be partially coated or printed with a mesh structure with a conductive material 117 to form a circuit.
  • the circuit can form two separate circuits, one circuit connected to the anode and the other connected to the cathode.
  • the circuit by the conductive material 117 may also not be electrically or physically connected.
  • the circuit part by the conductive material 117 may not be connected by the physical part or the chin part of the mask pack or the device mounted on the mask pack is not physically connected.
  • the mask pack according to one embodiment may further improve the flow of current to transfer more material.
  • the intermediate media sheet 116 comprises, at least partially, a conductive material, or is coated with a conductive material, or a conductive woven, or conductive non-woven material of the intermediate media sheet 116.
  • a conductive material for example, a nonwoven fabric.
  • the intermediate media sheet 116 may be in a dry form.
  • the material of the intermediate sheet is synthetic resin, for example, acrylic resin, urethane resin, silicone resin, styrene resin, aniline resin, amino resin, amino alkyd resin, vinyl acetate resin, alkyd resin, epoxy resin, toluene Resins, or combinations thereof.
  • the conductive material may be selected from the group consisting of carbon, gold, silver, aluminum, copper, steel use stainless (SUS), and combinations thereof.
  • the conductive material may use any one paste selected from the group consisting of carbon paste, gold paste, silver paste, aluminum paste, copper paste, SUS paste, and combinations thereof. Coating or printing of the conductive material may be coated by a method known to those skilled in the art, for example, by a method such as gravure printing, offset printing, digital printing, or transfer. One skilled in the art can determine the appropriate manner and amount of paste to be printed on the intermediate intermediate sheet to obtain the desired conductivity values.
  • the intermediate media sheet 116 may further include connecting portions 118 and 119 to be electrically connected to the battery unit 110.
  • the connection parts 118 and 119 may be the same as the conductive material 117.
  • the intermediate intermediate sheet 116 may play a role of causing a current generated from the battery unit 110 to flow into the material-containing sheet 120.
  • the intermediate media sheet 116 may be disposed on the region of interest of the face to which the substance is to be delivered when the mask pack is applied.
  • the mask pack is applied to the entire face by applying the material to be delivered to the object to the entire material-containing sheet 120, but a specific part of the face, for example, a lot of wrinkles, a lot of acne
  • the material in the mask pack can be better delivered.
  • One of ordinary skill in the art can appropriately determine the size and shape of the intermediate median sheet so that the material can transfer well to the area of interest on the face.
  • the intermediate sheet 116 may form a circuit such that a current generated in the battery unit 110 flows through the application site.
  • the conductivity of the intermediate sheet may range from 0.1 ohm / cm to 10 ohm /. may be cm. Specifically, the conductivity may be 10 ohm / cm or less, 8 ohm / cm or less, 6 ohm / cm or less, 4 ohm / cm or less, 2 ohm / cm or less, or 1 ohm / cm or less.
  • the mask sheet which is in direct contact with the skin may be pressed to make the mask pack adhere well to the skin.
  • the mask pack uses a battery with an electrode to deliver the bioactive material to the skin, thereby improving the delivery of the material, while preventing side effects that may occur in this process.
  • the device may include one or two battery units 110.
  • the battery unit When the battery unit is two, the battery unit 110 may be disposed on the same surface of the intermediate sheet 116. Further, each positive electrode 132 of the two battery units 110 is electrically connected by the conductive portion 117 of the intermediate intermediate sheet 116, and each negative electrode 131 is also connected to the intermediate intermediate sheet 116. It may be electrically connected by a conductive portion 117 (eg, a portion coated with a conductive material). In addition, as described above, the positive electrode 132 and the negative electrode 131 of the two battery units 110 are connected to an insulating portion (eg, a portion not coated with a conductive material) of the intermediate intermediate sheet 116. The current generated from the negative electrode 131 and the positive electrode 132 of the battery may not be electrically connected.
  • Another aspect provides a mask pack comprising the apparatus.
  • the mask pack includes the apparatus 101; And an intermediate sheet 116 of the device may include a material-containing sheet 120 connected to an opposite surface of the surface connected to the battery unit 110.
  • the apparatus 101 is as described above.
  • the mask pack comprises a battery unit 110 having a positive electrode and a negative electrode; An intermediate intermediate sheet 116 electrically connected to a positive electrode and a negative electrode of the battery unit, respectively; And one or two first or second material-containing sheets 120 connected to one surface of one of the two intermediate media sheets 116 or one surface of each of the two intermediate media sheets 116.
  • the intermediate intermediate sheet 116 may be configured to allow a current generated from the battery unit to flow into the material-containing sheet 120.
  • the material-containing sheet 120 may be configured to transfer the material in the material-containing sheet 120 to the object by the current generated from the battery unit 110.
  • the material-containing sheet 120 may be connected to a surface on which the conductive material 117 is printed, and the material-containing sheet 120 may be connected to a surface opposite to the surface on which the conductive material 117 is printed.
  • the first or second material-containing sheet 120 may include a material to be delivered to the object in both the first and second material-containing sheets 120, or a material to be delivered to the object may be included in the first material-containing sheet 120. It may be included only in (120).
  • the material-containing sheet 120 may be in a wet form.
  • the material-containing sheet 120 may be configured to include a material to be delivered to an object in an electrolyte solution, essence, hydrogel, cellulose, agarose, gelatin or collagen.
  • the mask pack when the material-containing sheet 120 is cellulose, the mask pack may be a cellulose pack, and in the case of collagen, the mask pack may be a collagen pack.
  • the cellulose pack or mask pack is used as known in the art.
  • the material-containing sheet may mean a general sheet for use as a conventional mask pack.
  • the material-containing sheet may also include an electrolyte, and examples of the electrolyte may include NaCl, MgCl 2 , AgCl, CuCl 2 , CaCl 2 , or a combination thereof.
  • the concentration of the electrolyte contained in the material-containing sheet is, for example, 0.01% to 0.2%, 0.02% to 0.18%, 0.05% to 0.18%, 0.08% to 0.15%, 0.08% to 0.12%, or 0.08%, 0.09 %, 0.1%, or 1.1%.
  • the material-containing sheet can have an appropriate conductivity value without deteriorating the usability of the material-containing sheet, so that the material in the material-containing sheet can be better delivered to the application site.
  • the material-containing sheet may further include a water-soluble polysaccharide, for example, arabio galactan. By adding the water-soluble polysaccharide in the substance-containing sheet, there is an effect that can further increase the conductivity.
  • the material-containing sheet 120 may include a material having a charge or polarity.
  • the substance may be a substance to be delivered to a subject.
  • the substance-containing sheet 120 is provided with a substance to be delivered to the object, or is contained in a separate container to be delivered to the subject in a separate container without the substance to be delivered to the object.
  • the substance can be provided.
  • the material-containing sheet 120 may include an aqueous solution or buffer, a hydrogel or a matrix containing or containing a material having a charge or polarity.
  • the material included in the material-containing sheet may be mixed with an enhancer material having a property of promoting mass transfer.
  • the enhancer can be broadly divided into enzymatic and non-enzymatic enhancers.
  • Enzymatic enhancers include enhancers using proteolytic enzymes such as papain, trypsin, pepsin, bromelai, and non-enzymatic enhancers include lactam compounds, ethyl acetate, ethyl alcohol, dioxolane, nonionic surfactants, and fluorene glycols.
  • the matrix material may also include acrylic or methacrylic resins such as polymers of alcohols with esters of acrylic acid or methacrylic acid.
  • the alcohol may include butanol, pentanol, isopentanol, 2-methyl butanol, 3-methyl pentanol, 2-ethylbutanol, isooctanol, decanol, or dodecanol.
  • the polymer may be acrylic acid, methacrylic acid, acrylamide, methacrylamide, N-alkoxymethylacrylamide, N-alkoxymethyl methacrylamide, Nt-butylacrylamide, itaconic acid, vinyl acetate, Copolymers with ethylenically unsaturated monomers such as N-branched alkyl maleamic acid glycol diacrylates, or mixtures thereof.
  • matrix materials include natural or synthetic rubbers such as styrenebutadiene, butylether, neoprene, polyisobutylene, polybutadiene and polyisoprene, polyvinylacetate, ureaformaldehyde resins, phenolformaldehyde resins, resorcinol formaldehyde resins Cellulose derivatives such as ethyl cellulose, methyl cellulose, nitrocellulose, cellulose acetate butyrate, and carboxymethyl cellulose, and natural gums such as guar, acacia, pectin, starch, dextrin, albumin, gelatin, casein and the like. These materials can include adhesives and stabilizers as are well known in the art.
  • the subject to which the substance is delivered in contact with the substance-containing sheet may be a mammal for humans and other purposes.
  • the material having a charge or polarity included in the material-containing sheet 120 may be a material having charge or polarity by being charged or solvated in an ion conductive medium in the material-containing sheet.
  • the substance having the charge or polarity may include a physiologically active substance or drug.
  • the molecular weight (MW) of the material can be, for example, about 100 to about 2000, about 200 to about 2000, about 300 to about 1000, about 300 to about 800, or about 400 to about 7000.
  • the material may include a whitening agent, an anti-wrinkle agent, a medicament or a combination thereof.
  • whitening agent examples include: mulberry extract, niacinamide, adenosine, arbutin, ethyl ascorbyl ether, oil soluble licorice extract, ascorbyl glucoside, ascorbyl triisopalmitate (ascorbyl tetraisopalmitate), magnesium ascorbyl phosphate, alpha-bisabolol or combinations thereof.
  • the anti-wrinkle agent examples include retinol, retinyl palmitate, adenosine, adenosine, polyethoxylated retinamide, acetyl hexapeptide (Acetyl hexapeptide-3 or 8), acetyl octapeptide ( Acetyl Octapeptide-3), Acetyl tetrapeptide-5, Palmitoyl pentapeptide, Copper peptide, Palmitoyl oligopeptide, Palmitoyl dipeptide-10 ), Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-3, Palmitoyl Hexapeptide-12, Pentapeptide -18, Leuphasyl) or combinations thereof.
  • the substance may be a protein.
  • the protein may be a protein that is modified to be included and delivered in a substance containing or protein in an ionized or io
  • the reverse electrodialysis battery unit 110 the cation exchange membrane 111; An anion exchange membrane 112 spaced apart from the cation exchange membrane 111; And chambers 113 and 114 containing an electrolyte at least partially defined with respect to the cation exchange membrane 111 and the anion exchange membrane 112 or disposed between the cation exchange membrane 111 and the anion exchange membrane 112.
  • the cation exchange membrane 111 and the anion exchange membrane 112 are alternately arranged, and the chamber is alternately arranged with a chamber 113 containing a high concentration of electrolyte and a chamber containing a low concentration of electrolyte 114. It may be.
  • the intermediate sheet 116 may be connected to electrode portions (cathode 131, anode 132) present on both outer surfaces of the reverse electrodialysis battery unit 110.
  • a chamber eg, a nonwoven fabric
  • a chamber for example, a nonwoven fabric
  • the anode 132 when the anion exchange membrane 112 is present.
  • electrons may be produced by an oxidation reaction at the cathode 131, and electrons may be consumed by a reduction reaction at the anode 132.
  • the mask pack 100 has a chamber (113, 114) containing the electrolyte as one layer, 2 to 70, 5 to 60, 7 to 40, 10 to 35 Or a plurality of cation exchange membranes 111, anion exchange membranes 112, and chambers 113 and 114 containing electrolytes, having 15 to 30 layers.
  • One surface of the material-containing sheet 120 may be in contact with the object S to which the substance is to be administered, so that a current generated from the reverse electrodialysis battery unit 110 may be transferred to the material through the intermediate media sheet 116.
  • cations (Na + ) in the chamber 113 containing a high concentration of electrolyte passes through the cation exchange membrane 111 and moves to the chamber 114 containing a low concentration of the electrolyte.
  • Anion (Cl ⁇ ) in the chamber 114 contained in the low concentration passes through the anion exchange membrane 112 and moves to the chamber 114 in which the electrolyte is included in the low concentration.
  • the movement of the ions occurs in all the cation exchange membrane 111, the anion exchange membrane 112, and the chambers 113 and 114.
  • an oxidation reaction occurs to produce electrons, and in the anode 132 to compensate for the relatively insufficient anion.
  • a reduction reaction occurs to consume electrons. Accordingly, the reverse electrodialysis battery unit 110 generates an ion current to output the current.
  • cations D + may penetrate (transfer) into the object through the skin, and the positive electrode 132 of the battery unit may be used.
  • the material containing sheet 120 connected to the negative ion (D ⁇ ) may be penetrated (transmitted) through the skin to the object.
  • the voltage or current formed in the reverse electrodialysis battery unit 110 may be adjusted by adjusting the type, thickness, or volume of the chambers 113 and 114 of the cation exchange membrane 111 and the anion exchange membrane 112. .
  • the thickness for determining the volume of the chambers 113 and 114 to accommodate the electrolyte is a chamber 113 in which the thickness of the chambers 113 and 114 in the middle portion of the battery unit 110 is present in the outer portion of the battery unit 110. , 114). In this way, the voltage or current output from the battery unit 110 can be increased.
  • the voltage output from the battery unit is at least about 0.5 Volt or more, for example, about 0.5 volts to about 15 volts, about 1.0 volts to about 10 volts, about 1.5 volts to about 8.0 volts, about 2.0 volts to about 6.0 volt, about 2.0 volts to about 4.0 volts, or about 2.0 volts to about 3 volts.
  • the current range output from the battery unit is at least about 0.1 mA or more, for example, about 0.1 mA to about 10 mA, about 0.2 mA to about 8 mA, about 0.4 mA to about 6 mA, about 0.5 mA to about 4 mA, about 0.5 mA to about 2 mA, or about 0.5 mA to about 1 mA.
  • the current may vary depending on skin resistance, and the skin resistance may be about 1000 to 3000 Ohm.
  • the term “reversed electrodialysis (RED)” may refer to a salinity gradient energy resulting from a difference in salt concentration between two solutions, and in one embodiment the mask pack 100 This may mean a phenomenon that causes a current to flow. Therefore, the reverse electrodialysis battery unit 110 may refer to a device for generating a current by using reverse electrodialysis. For example, in the present specification, the reverse electrodialysis battery unit 110 may generate a current by a difference in ion concentration of an electrolyte in a solution between a high concentration electrolyte solution and a low concentration electrolyte solution.
  • the mask pack 100 since the mask pack 100 uses reverse electrodialysis, a separate power source or electrode may not be required or may not have a separate power source or electrode.
  • the battery unit may be the only current source for delivering the material to the object.
  • the mask pack 100 may be formed of only the battery unit as a current source for transferring a material to an object, and the battery unit may not have a separate power source or an electrode.
  • the battery unit may use an electrolyte solution to form a current using the reverse electrodialysis battery unit 110.
  • electrolyte may refer to a material that is dissolved in a solvent such as water to dissociate into ions to flow a current
  • the electrolyte solution may refer to a solution such as water in which the electrolyte is dissolved. Therefore, the electrolyte may be contained in the electrolyte solution.
  • the reverse electrodialysis battery unit 110 generates a current through a difference between a high concentration electrolyte solution and a low concentration electrolyte solution, and the amount of the electrolyte in the chamber 113 including the high concentration of the electrolyte is a chamber containing the low concentration of the electrolyte. It may be higher than the amount of electrolyte in 114.
  • the chamber 114 in which the electrolyte is contained at a low concentration may include one in which the electrolyte is not included.
  • the electrolyte is contained in an electrolyte solution, and the chamber 113 containing the electrolyte at a high concentration is about 0.1 to about 20 mol / L, about 0.5 to about 15 mol / L, and about 0.7 to about 10 mol.
  • the chambers 113 and 114 including the electrolyte may include an electrolyte paste.
  • the electrolyte paste may include a water-soluble polymer binder and an electrolyte.
  • the water-soluble polymer binder is selected from the group consisting of, for example, cellulose resins, xanthan gum, polyvinylpyrrolidone, polyvinyl alcohol, water-soluble (meth) acrylic resins, polyether polyols, and polyetherurea-polyurethanes. There may be more than one.
  • the chamber containing the electrolyte paste may be manufactured by mixing the water-soluble polymer binder and the electrolyte to prepare an electrolyte paste. By using the electrolyte contained in the chamber as the electrolyte paste, the resistance can be lowered, and the electrolyte in the chamber can be moved better.
  • the chambers 113 and 114 including the electrolyte may contain a hydrogel containing the electrolyte.
  • the chamber 113 containing a high concentration of electrolyte contains a solid material containing a high concentration of electrolyte or a hydrogel containing a high concentration of electrolyte, or the chamber 114 containing a low concentration of the electrolyte includes
  • the solid material may be empty or contain a low concentration of electrolyte, or may contain a hydrogel containing a low concentration of electrolyte.
  • solid salt NaCl
  • the solid material or hydrogel may be used without limitation as long as the material has water permeability or permeability of ionic material and has appropriate mechanical properties.
  • examples of such solid materials or hydrogels include agar, polyethylene glycol diacrylate (PEGDA), poly (2-hydroxyethyl methacrylate) (PHEMA), alginic acid such as sodium alginate, calcium alginate, or potassium alginate can do.
  • PEGDA polyethylene glycol diacrylate
  • PHEMA poly (2-hydroxyethyl methacrylate)
  • alginic acid such as sodium alginate, calcium alginate, or potassium alginate can do.
  • the solid material or hydrogel may also comprise a solid powder formulation of the ionic binder.
  • Chambers 113 and 114 containing the electrolyte may be constructed of a woven or non-woven fabric capable of absorbing aqueous solutions.
  • the non-woven fabric can be a nonwoven.
  • the electrolyte may be included in the chamber in the form of a powder.
  • the electrolyte may be dissolved in the water to form an aqueous electrolyte solution, thereby causing the flow of ions.
  • the chambers 113 and 114 may be woven or non-fabric impregnated with electrolyte.
  • the electrolyte-impregnated fabric or non-woven fabric may be produced, for example, by hot air rolling process after the nonwoven fabric is placed in NaCl solution.
  • the chamber 113 containing a high concentration of electrolyte may be prepared through a hot air rolling process after putting a cloth or non-woven fabric capable of absorbing an aqueous solution in a high NaCl solution, and a chamber containing a low concentration of electrolyte ( 114) can be prepared through a hot air rolling process after putting a woven or non-woven fabric that can absorb an aqueous solution in a low NaCl solution.
  • the chamber 114 containing the electrolyte at low concentration may be constructed of a woven or non-woven fabric capable of absorbing aqueous solution without impregnating NaCl.
  • the amount of electrolyte or the ion concentration of the electrolyte solution in the chamber 113 and the chamber 114 in which the electrolyte is contained at a high concentration is at least about 0.5 Volt or more, for example, from about 0.1 volt to To output voltages of about 15 volts, about 0.2 volts to about 10 volts, about 1.0 volts to about 8.0 volts, about 2.0 volts to about 6.0 volts, about 2.0 volts to about 4.0 volts, or about 2.0 volts to about 3 volts Other amounts or ion concentrations.
  • 0.1 mA or more such as about 0.1 mA to about 10 mA, about 0.2 mA to about 8 mA, about 0.4 mA to about 6 mA, about 0.5 mA to about 4 mA, about 0.5 mA to about 2 mA Or in different amounts or ion concentrations to generate a current from about 0.5 mA to about 1 mA.
  • the electrolyte may include NaCl, MgCl 2 , AgCl, CuCl 2 , CaCl 2 , or a combination thereof.
  • the term "ion-exchange membrane” may refer to a membrane having a strong tendency to pass either of a cation or an anion.
  • the ion exchange membrane may be a synthetic resin, for example, the synthetic resin may be crosslinked.
  • the cation exchange membrane 111 has a negative charge, so that ions having a negative charge can pass ions having a positive charge without being repulsed and passed, for example, the cation exchange membrane 111 having a sulfone group.
  • the anion exchange membrane 112 since the anion exchange membrane 112 has a positive charge, ions having a positive charge can pass ions having a negative charge without repulsing and passing, for example, the anion exchange membrane 112 having a tetravalent ammonium.
  • the type of monomer forming the cation exchange membrane 111 is a sulfonic acid-type monomer, for example, 2- (meth) acrylamide-2-methylpropanesulfonic acid (2- (meth) acrylamide-2-methylpropanesulfonic acid) , 3-sulfopropane (meth) acrylate, 10-sulfodecane (meth) acrylate and salts thereof; Carboxylic acid-type monomers such as 2- (meth) acryloylethylphthalic acid, 2- (meth) acryloylethylsuccinic acid 2- (meth) acryloylethylmaleic acid, 2- (meth) acryloylethyl-2-hydroxyethylphthalic acid, 2- (meth) acryloylethyl-2-hydroxyethylphthalic acid ), 11- (meth) acryloyloxydecyl-1,1-dicarboxylic acid (11- (meth)
  • the monomer forming the anion exchange membrane 112 is N, N-dimethylaminoethyl (meth) acrylate (N, N-dimethylaminoethyl (meth) acrylate), N, N-diethylaminodecyl (meth) acrylate (N, N-diethylaminoethyl (meth) acrylate), N, N-dimethylaminoethyl (meth) acrylate / methyl chloride, and N, N-diethylamino N, N-diethylaminoethyl (meth) acrylate / methyl chloride may be included.
  • the ion exchange capacity (IEC) of the cation exchange membrane 111 or the anion exchange membrane 112 is about 0.5 meg / g or more, or about 1.0 meg / g or more, for example, about 0.5 to about 20.0 meg / g. , About 1.0 to about 10.0 meg / g, about 2.0 to about 10.0 meg / g, about 5.0 to about 10.0 meg / g.
  • the permeation selectivity of the cation exchange membrane 111 or the anion exchange membrane 112 is about 70% or about 80% or more, for example, about 80 to about 100%, about 90 to about 100%, or about 95 to about 100 May be%.
  • the mask pack 100 may further include a spacer (not shown) for separating the cation exchange membrane 111 and the anion exchange membrane 112.
  • the spacer may be the same as the chambers 113 and 114 containing the electrolyte.
  • the spacer may serve to prevent the ion exchange membranes from sticking, and may include, for example, a mesh made of polypropylene or polyethylone, a sponge, an adhesive tape, or a fabric such as a cloth or a nonwoven fabric. Can be.
  • the spacer may serve as a support for supporting the cation and anion exchange membrane 112 and the chambers 113 and 114 containing the electrolyte.
  • the support may be, for example, a gasket.
  • the reverse electrodialysis battery unit 110 may further include a container 115 for accommodating the reverse electrodialysis battery unit 110.
  • the container 115 may be configured to include a hole or to expose a portion of the reverse electrodialysis battery unit 110 to administer a solution for activating the reverse electrodialysis battery unit 110.
  • a plurality of holes of the container 115 may be formed in the longitudinal direction of the container. The length direction may mean a direction parallel to the exchange membrane of the reverse electrodialysis battery unit. In addition, additional holes may be appropriately selected and formed by those skilled in the art.
  • the container 115 may serve to maintain and support components in the reverse electrodialysis battery unit 110.
  • the container 115 may prevent the solution in the chambers 113 and 114 from leaking.
  • a portion of the container 115 is a spacer (not shown), for example, a double-sided tape, and may serve as the spacer as described above.
  • the container may be an insulator, and any material conventionally used may be used as the material of the container.
  • Optional materials include, for example, cellophane, cellulose acetate, ethylcellulose, plasticized vinyl acetate-vinylchloride copolymer, polyethylene terephthalate, nylon, polyethylene, polypropylene, polyvinylidene chloride, rubber, soft plastics, rigid plastics.
  • the reverse electrodialysis cell is a side wall of the chambers 113 and 114, as shown in FIG. 7A, on at least a portion of the side wall positioned between the cation exchange membrane 111 and the anion exchange membrane 112.
  • Water permeable membrane 140 may be disposed.
  • the water supply unit 130 supplying water to the chambers 113 and 114 may be connected to at least a portion of sidewalls of the chambers 113 and 114.
  • the water supply unit 130 and the chambers 113 and 114 may be in fluid communication by a flow path or a channel (not shown).
  • the side wall may refer to a side other than a side facing the chambers.
  • the water in the water supply 130 is introduced into the chambers 113 and 114 through the water permeable membrane 140, whereby the flow of ions described above is shown as shown in FIG. 7C. This can be formed.
  • the device may be activated by any means for generating electrolyte ion concentration differences in the chambers 113, 114 of the device. For example, the device may be activated by supplying water to activate the device before or after the user contacts the device with the skin.
  • Still another aspect provides a kit comprising a mask pack comprising the device or the device mounted to the mask pack.
  • the kit may include a container containing an aqueous solution (eg, water) for activating the device mounted on the mask pack.
  • the aqueous solution may include an electrolyte.
  • the aqueous solution for the activation may be a material having a viscosity, for example, hydrogel.
  • the electrolyte is as described in the electrolyte contained in the material-containing sheet.
  • the kit may further include a container containing a substance to be delivered to the subject.
  • the mask pack may be provided as a kit with a material contained in a specific container in a state in which the material to be delivered to the object is not included.
  • the substance to be delivered to the subject may be provided in the form of a composition or substance powder containing the substance.
  • the composition comprising the substance may be provided in the form of a cream, gel, liquid, essence, serum, etc. containing the substance.
  • the composition comprising the substance has a certain viscosity or more, and the user can deliver the substance in vivo by applying the substance to a material-containing sheet.
  • the user applies the drug to the mask pack, activates the mask pack using the aqueous solution, and contacts the skin of the person or another person with the substance. Can be delivered in vivo.
  • FIG. 8 is a photograph of a device mounted on a mask pack manufactured according to one embodiment.
  • a nonwoven fabric was used as the intermediate intermediate sheet, and 0.5 g of silver paste (Daeju Electronics, South Korea) was printed on the nonwoven fabric.
  • Ethyl carbitol acetate was used as a solvent for viscosity control.
  • a thermal process was performed at 120 ° C. for 3 to 4 hours to remove a solvent harmful to the human body, and the cooling and deodorization processes were simultaneously performed through an air process for at least 1 hour.
  • the marking was printed on the roll on which the silver paste was printed, so that the mark was sensed during the perforation, so that the perforation was possible within the error range.
  • the conductivity of the intermediate media sheet obtained through this process was about 1 ohm / cm.
  • a reverse electrodialysis battery was used as the battery part. Specifically, a nonwoven fabric having a thickness of about 0.2 to 0.5 mm was used as the chamber containing the electrolyte.
  • the cation exchange membrane and the anion exchange membrane were purchased from ASAHI GLASS Co. and used.
  • SBX tape (CROSS, SBX tape) was used as the spacer, container, or support for attaching the nonwoven fabric, cation exchange membrane, and anion exchange membrane.
  • the SBX tape was drilled to allow ion exchange to take place to allow the solution to be placed in the chamber containing the electrolyte.
  • the NaCl powder was placed on the nonwoven fabric by a predetermined amount so that the chamber containing the electrolyte at a high concentration was 1.72 M, and the chamber containing the electrolyte at a low concentration was 0.011 M.
  • Each configuration of the reverse electrodialysis battery unit was prepared as described above, and the respective configurations were stacked in the stacking order of the reverse electrodialysis battery unit described above.
  • the area of the chamber was 1.5 cm ⁇ 1.3 cm, and the chamber was used as one layer to prepare a reverse electrodialysis cell part having 31 layers. Voltage and current were measured by contacting a copper copper plate with a reverse electrodialysis cell using Ammeter Keysight's digital multimeter 34410A.
  • connection between the battery unit and the intermediate media sheet was performed by an ultrasonic process.
  • the process of inserting the reverse electrodialysis cell into the support (ie, the container) was performed manually and the battery part was connected with the sheet.
  • the lower portion of the support and the portion where the silver paste of the intermediate medium sheet was not printed, and the electrode and the portion of the silver paste printed on the battery were connected by an ultrasonic process.
  • a device to be mounted on the mask pack was manufactured, and the sheet containing the material was applied to the skin using a microfiber mask (PNC industry, Korea) of wet form.
  • a aqueous solution for activating the mask pack was used an aqueous solution containing NaCl in a concentration of 0.1%.
  • the experiment was applied to the pig skin whether the material is well delivered. Specifically, first, frozen frozen pig skin purchased from the slaughterhouse was prepared by melting 2-3 hours at room temperature. After removing the hair on the pig skin, using a pin to stretch the pig skin to have elasticity was fixed on the plate. As a test group, a mask pack according to one embodiment prepared above was applied to pig skin for 30 minutes, and as a test group, a mask pack without RED battery was applied for 30 minutes. 0.5 mM calcein (Calcein, MW 622.55 g / mol, Sigma-Aldrich) as a fluorescent reagent was used for the material containing portion.
  • Pig skin was then sampled and fixed for 24 hours with 4% paraformaldehyde (pH 7.4, 4 ° C.) fixative. After fixation, the solution was sufficiently washed with PBS (pH 74) solution, embedded in Tissue-Tek OCT compound (Sakura Finetek; USA), and rapidly cooled. The cooled sample was cut to a size of 7 um using a freezing section (Shandon Cryotome SME Cryostat, Shandon Scientific LTD, Cheshire, England). Cryoprepared tissues were washed with PBS solution, covered in mounting solution and covered with cupper slip, and then observed under a fluorescence microscope (Axio Observer Z1; Zeiss, Gottingen, Germany) and the results are shown in FIG. .
  • the above fluorescence was quantified using a spectrophotometer, and the results are shown in FIG. 12. 11 and 12, while in the control group, the fluorescence did not penetrate the stratum corneum, while the mask pack according to one embodiment was confirmed that the fluorescence was deeply transmitted beyond the stratum corneum.
  • the skin using reverse electrodialysis increased approximately 7 times (0.47 ng / cm 2 ) compared to the amount of penetration of the passive diffusion skin (about 0.05 ng / cm 2 ).
  • vitamin C skin absorption in mice was evaluated. Specifically, an intradermal cumulative amount test of vitamin C was performed using hairless mouse skin. As a control, a formulation containing vitamin C in a general patch was used, and a formulation containing vitamin C in a patch using reverse electrodialysis was used as a test group. An adhesive hydrogel type patch was prepared using 3 w / v% Cabopol, and 0.5 mL of vitamin C-containing adhesive hydrogel was loaded into the patch (vitamin C content: 2.5 w / v%; vitamin C loading per patch: 12.5 mg). The back skin of 5 week old (20-25 g) mice was removed and the above patches were mounted.
  • HPLC high performance liquid chromatography
  • the mask pack according to one embodiment is adhered to the skin well, the delivery of the bioactive material through the skin is improved, and occurs in the process of delivering the bioactive material to the skin using a device having an electrode It was confirmed that there is an effect that can prevent itching, pain, burning, and erythema.

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Abstract

La présente invention concerne un appareil monté sur un masque facial, et un masque facial et un kit comprenant celui-ci. Selon un aspect, l'invention concerne un appareil monté sur un masque facial et un masque facial comprenant celui-ci ayant comme effets : le masque facial est bien fixé sur les parties sur lesquelles est appliqué ledit masque facial telles que la peau; l'administration d'une matière biologiquement active à travers la peau est améliorée; et l'apparition de prurit, d'une douleur, d'une sensation de brûlure et d'érythème, qui pourrait se produire pendant l'administration de la matière biologiquement active sur la peau par un appareil à électrodes, est évitée.
PCT/KR2017/000151 2016-01-05 2017-01-05 Appareil monté sur un masque facial, et masque facial et kit comprenant celui-ci WO2017119742A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US15/777,410 US10945516B2 (en) 2016-01-05 2017-01-05 Device mounted on mask pack, mask pack and kit comprising the same
CN201780005802.3A CN108601935B (zh) 2016-01-05 2017-01-05 安装在面膜上的装置以及包括该装置的面膜和成套工具
SG11201703910UA SG11201703910UA (en) 2016-01-05 2017-01-05 Device Mounted On Mask Pack, Mask Pack And Kit Comprising The Same
JP2018536198A JP6641015B2 (ja) 2016-01-05 2017-01-05 マスクパックに取り付けられる装置、これを含むマスクパック及びキット

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR20160000772 2016-01-05
KR10-2016-0000772 2016-01-05
KR1020160072695A KR20170082111A (ko) 2016-01-05 2016-06-10 마스크팩에 장착되는 장치, 그를 포함하는 마스크팩 및 키트
KR10-2016-0072695 2016-06-10
KR10-2017-0001760 2017-01-05
KR1020170001760A KR101855500B1 (ko) 2016-01-05 2017-01-05 마스크팩에 장착되는 장치, 그를 포함하는 마스크팩 및 키트

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107550755A (zh) * 2017-10-27 2018-01-09 广州市花安堂生物科技有限公司 一种温和保湿淡化细纹的组合物及其制备方法
CN109879936A (zh) * 2019-03-11 2019-06-14 南京工业大学 一种利用微通道模块化反应装置合成棕榈酰六肽的方法

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US5637084A (en) * 1992-03-10 1997-06-10 Kontturi; Kyoesti E. A. Electrochemical method and device for drug delivery
KR20070078184A (ko) * 2006-01-26 2007-07-31 주식회사 엘지생활건강 파지가 용이한 이온토포레시스 장치
US20090254018A1 (en) * 2005-08-24 2009-10-08 Mizuo Nakayama Electrode assembly for freezing-type iontophoresis device
JP2009256295A (ja) * 2008-04-11 2009-11-05 Kosumedei Seiyaku Kk 化粧用粘着シート
KR101511990B1 (ko) * 2013-09-24 2015-04-14 한국에너지기술연구원 역전기투석 장치용 이온 교환막 및 이를 포함하는 역전기투석 장치

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Publication number Priority date Publication date Assignee Title
US5637084A (en) * 1992-03-10 1997-06-10 Kontturi; Kyoesti E. A. Electrochemical method and device for drug delivery
US20090254018A1 (en) * 2005-08-24 2009-10-08 Mizuo Nakayama Electrode assembly for freezing-type iontophoresis device
KR20070078184A (ko) * 2006-01-26 2007-07-31 주식회사 엘지생활건강 파지가 용이한 이온토포레시스 장치
JP2009256295A (ja) * 2008-04-11 2009-11-05 Kosumedei Seiyaku Kk 化粧用粘着シート
KR101511990B1 (ko) * 2013-09-24 2015-04-14 한국에너지기술연구원 역전기투석 장치용 이온 교환막 및 이를 포함하는 역전기투석 장치

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107550755A (zh) * 2017-10-27 2018-01-09 广州市花安堂生物科技有限公司 一种温和保湿淡化细纹的组合物及其制备方法
CN107550755B (zh) * 2017-10-27 2019-01-25 花安堂生物科技集团有限公司 一种温和保湿淡化细纹的组合物及其制备方法
CN109879936A (zh) * 2019-03-11 2019-06-14 南京工业大学 一种利用微通道模块化反应装置合成棕榈酰六肽的方法
CN109879936B (zh) * 2019-03-11 2020-11-17 南京工业大学 一种利用微通道模块化反应装置合成棕榈酰六肽的方法

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