WO2017101549A1

WO2017101549A1 - Biosensor circuit temperature drift compensation system and method

Info

Publication number: WO2017101549A1
Application number: PCT/CN2016/100010
Authority: WO
Inventors: 张贯京; 葛新科; 陈兴明; 高伟明
Original assignee: 深圳市贝沃德克生物技术研究院有限公司
Priority date: 2015-12-18
Filing date: 2016-09-24
Publication date: 2017-06-22
Also published as: CN105466460A; CN105466460B

Abstract

A biosensor circuit temperature drift compensation system for use in a single chip microcomputer (1); a first digital potentiometer (2), a second digital potentiometer (3), and a digital switch (4) are connected to the single chip microcomputer (1), two output terminals of the digital switch (4) being connected to two input terminals of a biosensor circuit (5), and an output terminal of the biosensor circuit (5) being connected to the single chip microcomputer (1); the single chip microcomputer (1) controls the resistance values of a first balancing resistor (DR1) in the first digital potentiometer (2) and a second balancing resistor (DR2) in the second digital potentiometer (3) in order to automatically zero-adjust the voltage generated in the biosensor due to circuit temperature drift, and fixes the resistance values of the first digital potentiometer (2) and the second digital potentiometer (3) at the time of the zero-adjustment of the output voltage of the biosensor. The present invention can stabilise the electrical properties of the biosensor, improve the accuracy and working efficiency of voltage zero adjustment, and eliminate the adverse effect of circuit temperature drift on the sensitivity of the biosensor. Also disclosed is a biosensor circuit temperature drift compensation method.

Description

Circuit temperature drift compensation system and method for biosensor

[0001] The present invention relates to the field of biosensors, and in particular, to a circuit temperature drift compensation system and method for a biosensor.

Background technique

[0002] The temperature drift of a circuit generally means that the change of the ambient temperature will cause a change in the transistor parameters in the circuit, which will cause instability of the static operating point, make the dynamic parameters of the circuit unstable, and even make the circuit unable to work normally. In general, as the temperature rises, the current amplification factor of the transistor increases, and the Q point rises, and vice versa. This extra added current is caused by temperature changes, called temperature drift. In a directly coupled amplifier circuit, even if the input is short-circuited, the output is measured with a sensitive DC meter, and there is a slow-changing output voltage. This phenomenon in which the input voltage is zero and the output voltage is not zero and changes slowly is called zero-point drift. In the amplifying circuit, any parameter variation, such as fluctuations in the power supply voltage, aging of the components, and changes in the parameters of the semiconductor components with temperature, will cause a drift in the output voltage. The change in the parameters of the semiconductor device caused by the temperature change is the main cause of the zero drift phenomenon, so the zero drift is also called the temperature drift.

[0003] Generally, biosensors (eg, blood glucose, body temperature, heart rate sensors, etc. in the vital sign monitoring sensor) require very high sensitivity, and if the temperature drift of the circuit in such a biosensor significantly affects the resistance value in the circuit. The change causes the output voltage to be unstable, which affects the sensitivity of the biosensor. In order to eliminate the temperature drift caused by the circuit, the voltage of the output of the biosensor circuit is often zeroed by a temperature compensation circuit including a sliding resistor. However, the debugger typically manually adjusts the output voltage of the biosensor circuit by manually adjusting the sliding resistor in the temperature compensation circuit. This manual adjustment circuit temperature drift is difficult to zero the accuracy of the output voltage of the biosensor circuit, and the efficiency is low, so that the adverse effect of the circuit temperature drift on the sensitivity of the biosensor cannot be completely eliminated.

technical problem

The main object of the present invention is to provide a circuit temperature drift compensation system and method for a biosensor, which aims to solve the problem that the temperature drift of the manual adjustment circuit is not high and the efficiency is low. Problem solution

Technical solution

[0005] In order to achieve the above object, the present invention provides a circuit temperature drift compensation system for a biosensor, which is applied to a single chip microcomputer, wherein the single chip is connected with a first digital potentiometer, a second digital potentiometer, and a digital switch. The two output terminals of the digital sensor are respectively connected to the two input ends of the biosensor circuit, and the output end of the biosensor circuit is connected to the single chip microcomputer, wherein the circuit temperature drift compensation system comprises:

[0006] a control module for generating a shut-off command to control the digital switch to make the voltage difference at the input end of the biosensor circuit is zero;

[0007] a potentiometer control module, configured to generate a first control command to control a contact slip of the first balance resistor in the first digital potentiometer to change a resistance value of the first digital potentiometer, and generate a second control command to control the second The contact of the second balancing resistor in the digital potentiometer slides to change the resistance value of the second digital potentiometer;

[0008] a voltage compensation module, configured to dynamically adjust an output voltage of the biosensor circuit according to a resistance value of the first digital potentiometer and a resistance value of the second digital potentiometer, and to detect an output voltage of the biosensor circuit Whether it is zero;

[0009] when the output voltage of the biosensor circuit is zero, the potentiometer control module is further configured to control a second balance of the first balance resistor of the first digital potentiometer and the second digital potentiometer The contacts of the resistor stop sliding and fix the position.

[0010] Preferably, the two input terminals of the digital switch are respectively connected to two output ends of the measuring component, and the switch control module is further configured to: when the output voltage of the biosensor circuit is zero, A closing command is generated to control the digital closing to cause the potential measuring signal generated by the measuring component to pass through the biosensor circuit and to detect the accuracy of the potential measuring signal.

[0011] Preferably, the first digital potentiometer comprises a first voltage stabilizing resistor, the second digital potentiometer comprises a second voltage stabilizing resistor, and the first voltage stabilizing resistor and the second voltage stabilizing resistor are used for The contacts of the first balance resistor and the second balance resistor slide 吋 to maintain a stable voltage of the first digital potentiometer and the second digital potentiometer.

[0012] Preferably, one end of the first balancing resistor and the first voltage stabilizing resistor is connected to a positive input terminal of the biosensor circuit, and the other end of the first balancing resistor and the first voltage stabilizing resistor is grounded, the second Balance resistance One end of the second voltage stabilizing resistor is connected to the negative input terminal of the biosensor circuit, and the other end of the second balancing resistor and the second voltage stabilizing resistor is connected to the output end of the biosensor circuit.

[0013] Preferably, the control terminals of the first balance resistor, the second balance resistor and the digital switch are respectively connected to the control end of the single chip microcomputer.

[0014] In order to achieve the above object of the present invention, the present invention further provides a circuit temperature drift compensation method for a biosensor, which is applied to a single chip microcomputer, wherein the single chip is connected with a first digital potentiometer, a second digital potentiometer, and a digital port. Off, the two outputs of the digital switch are respectively connected to two inputs of the biosensor circuit, and the output of the biosensor circuit is connected to the single chip, and the circuit temperature drift compensation method comprises the steps of:

[0015] generating a shut-off command to control the digital shut-off so that the voltage difference at the input of the biosensor circuit is zero;

[0016] generating a first control command to control the sliding of the contact of the first balancing resistor in the first digital potentiometer to change the resistance value of the first digital potentiometer;

[0017] generating a second control command to control the contact sliding of the second balancing resistor in the second digital potentiometer to change the resistance value of the second digital potentiometer;

[0018] dynamically adjusting the output voltage of the biosensor circuit according to the resistance value of the first digital potentiometer and the resistance value of the second digital potentiometer;

[0019] detecting whether the voltage at the output end of the biosensor circuit is zero;

[0020] when the output voltage of the biosensor circuit is zero, the contacts controlling the first balance resistor of the first digital potentiometer and the contacts of the second balance resistor of the second digital potentiometer stop sliding simultaneously Fixed position

[0021] Preferably, the two input terminals of the digital switch are respectively connected to two output ends of the measuring component, and the circuit temperature drift compensation method further comprises the steps of:

[0022] when the output voltage of the biosensor circuit is zero, generating a 幵 closing command to control the digital 幵 closing so that the potential measurement signal generated by the measuring component passes through the biosensor circuit and detects the potential measurement signal. Accuracy.

[0023] Preferably, the first digital potentiometer comprises a first voltage stabilizing resistor, the second digital potentiometer comprises a second voltage stabilizing resistor, and the first voltage stabilizing resistor and the second voltage stabilizing resistor are used for The first balance resistor and the first The contacts of the two balancing resistors slide 吋 to maintain a stable voltage of the first digital potentiometer and the second digital potentiometer.

[0024] Preferably, one end of the first balancing resistor and the first voltage stabilizing resistor is connected to a positive input terminal of the biosensor circuit, and the other end of the first balancing resistor and the first voltage stabilizing resistor is grounded, the second One end of the balancing resistor and the second voltage stabilizing resistor is connected to the negative input terminal of the biosensor circuit, and the other end of the second balancing resistor and the second voltage stabilizing resistor is connected to the output end of the biosensor circuit.

[0025] Preferably, the control terminals of the first balance resistor, the second balance resistor and the digital switch are respectively connected to the control end of the single chip microcomputer.

Advantageous effects of the invention

Beneficial effect

[0026] Compared with the prior art, the circuit temperature drift compensation system and method of the biosensor of the present invention shifts the biosensor due to circuit temperature by controlling the resistance values of the first digital potentiometer and the second digital potentiometer. The voltage generated by the phenomenon is automatically zeroed, and the resistance values of the first digital potentiometer and the second digital potentiometer of the biosensor output voltage are adjusted to zero, thereby stabilizing the electrical characteristics of the biosensor output and improving the voltage zeroing. The high accuracy and work efficiency eliminates the adverse effects of circuit temperature drift on the sensitivity of the biosensor.

Brief description of the drawing

DRAWINGS

1 is a schematic diagram of an application environment of a preferred embodiment of a circuit temperature drift compensation system of a biosensor of the present invention;

2 is a schematic diagram of functional modules of a preferred embodiment of a circuit temperature drift compensation system of the biosensor of the present invention;

3 is a flow chart of a preferred embodiment of a circuit temperature drift compensation method for a biosensor of the present invention.

[0030] The implementation, functional features, and advantages of the present invention will be further described with reference to the accompanying drawings.

BEST MODE FOR CARRYING OUT THE INVENTION

[0031] In order to further illustrate the technical means and effects of the present invention for achieving the above objectives, the following knots The specific embodiments, structures, features and effects of the present invention are described in detail with reference to the drawings and preferred embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0032] In order to achieve the object of the present invention, the present invention provides a circuit temperature drift compensation system for a biosensor, which can automatically zero the voltage generated by the biosensor due to the temperature drift of the circuit, thereby reducing the biological temperature drift caused by the circuit. The sensitivity of the sensor affects the accuracy of the circuit temperature drift compensation and the efficiency of the work.

1, FIG. 1 is a schematic diagram of an application environment of a preferred embodiment of a circuit temperature drift compensation system of a biosensor of the present invention. In this embodiment, the circuit temperature drift compensation system 10 is applied to the single chip microcomputer 1, and the single chip microcomputer 1 is connected with a first digital potentiometer 2, a second digital potentiometer 3, and a digital switch 4. The two outputs of the digital switch 4 are connected to two inputs of a biosensor circuit 5, the output of which is connected to the microcontroller 1. The two inputs of the digital switch 4 are connected to the two outputs of the measuring element 6, respectively.

[0034] In this embodiment, the first digital potentiometer 2 includes a first balancing resistor DR1 and a first voltage stabilizing resistor R1, and the second digital potentiometer 3 includes a second balancing resistor DR2 and a second stable Voltage resistor R2. One ends of the first balancing resistor DR1 and the first voltage stabilizing resistor R1 are connected to the positive input terminal of the biosensor circuit 5, and the other ends of the first balancing resistor DR1 and the first voltage stabilizing resistor R1 are grounded. One ends of the second balancing resistor DR2 and the second voltage stabilizing resistor R2 are connected to the negative input terminal of the biosensor circuit 5, and the other ends of the second balancing resistor DR2 and the second voltage stabilizing resistor R2 are connected to the biosensor circuit 5. The output. The first balancing resistor DR1 and the second balancing resistor DR2 are respectively connected to the control terminals of the single chip microcomputer 1.

[0035] When the contacts of the first balancing resistor DR1 and the second balancing resistor DR2 slide to the zero-terminal resistance value 吋, generating a higher voltage may damage the biosensor circuit 5, and therefore, the first voltage regulator is used in this embodiment. The resistor R1 and the second voltage stabilizing resistor R2 ensure the stability of the output voltages of the first digital potentiometer 2 and the second digital potentiometer 3. The first voltage stabilizing resistor R1 and the second voltage stabilizing resistor R2 are used to keep the first digital potentiometer 2 and the second digital potentiometer 3 output when the contacts of the first balancing resistor DR1 and the second balancing resistor DR2 slide. The voltage is stabilized, thereby protecting the biosensor circuit 5 from damage due to excessive voltage.

[0036] The digital switch 4 includes a first switch K1 and a second switch K2, the output of the first switch K1 and the output of the second switch 2 are respectively connected to the two inputs of the biosensor circuit 5 End, the input of the first switch K1 The inputs of the second switch K2 are connected to the two outputs of the measuring element 6, respectively. The microcontroller 1 controls the first switch K1 and the second switch 2 to open and close by controlling the control terminal of the digital switch 4. The control terminal b of the digital switch 4 is connected to the control terminal of the microcontroller 1.

[0037]

2 is a schematic diagram of functional modules of a preferred embodiment of a circuit temperature drift compensation system for a biosensor of the present invention. In the embodiment, the circuit temperature drift compensation system 10 is installed and operated in the single chip microcomputer 1. The single chip microcomputer 1 further includes, but is not limited to, the microcontroller 11 and the memory 12. The circuit temperature drift compensation system 10 includes, but is not limited to, a control module 101, a potentiometer control module 102, and a voltage compensation module 103. The module referred to in the present invention refers to a series of computer program instruction segments which can be executed by the microcontroller 11 of the microcontroller 1 and which can perform a fixed function, which are stored in the memory 12 of the microcontroller 1.

In this embodiment, the microcontroller 11 can be a microprocessor, a micro control unit (MCU), a signal processing chip, or a signal control unit having a signal control function. The memory 12 can be a read only memory ROM, an electrically erasable memory EEPROM or a flash memory FLASH or the like.

[0040] The switch control module 101 is configured to generate a switch off command to control the digital switch 4 to make the input terminal voltage difference of the biosensor circuit 5 zero.

[0041] the potentiometer control module 102 is configured to generate a first control command to control the contact sliding of the first balancing resistor DR1 of the first digital potentiometer 2 to change the resistance value of the first digital potentiometer, and generate a second control The command controls the contact of the second balancing resistor DR2 in the second digital potentiometer 3 to change the resistance value of the second digital potentiometer.

[0042] The voltage compensation module 103 is configured to dynamically adjust the output voltage of the biosensor circuit 5 according to the resistance value of the first digital potentiometer 2 and the resistance value of the second digital potentiometer 3, and to detect the biosensor Is the output voltage of circuit 5 zero?

[0043] When the output voltage of the biosensor circuit 5 is zero, the potentiometer control module 102 is further configured to control the contacts of the first balancing resistor DR1 of the first digital potentiometer 2 and the second digital potentiometer 3 Second balance resistance

The contacts of the DR2 stop sliding and fix the position.

[0044] When the output voltage of the biosensor circuit 5 is zero, the switching control module 101 is further configured to generate a closing command to control the closing of the digital switch 4 to pass the potential measuring signal generated by the measuring component 6 The biosensor circuit 5 detects the accuracy of the potential measurement signal.

[0045]

[0046] In order to achieve the object of the present invention, the present invention also provides a circuit temperature drift compensation method for a biosensor

In the single-chip microcomputer 1, the voltage generated by the biosensor due to the circuit temperature drift phenomenon can be automatically zeroed, thereby reducing the sensitivity of the biosensor due to the temperature drift of the circuit, improving the accuracy of the circuit temperature drift compensation, and improving The working efficiency of circuit zeroing.

As shown in FIG. 3, FIG. 3 is a flow chart of a preferred embodiment of a circuit temperature drift compensation method for a biosensor of the present invention. In this embodiment, the circuit temperature drift compensation method is applied to the single chip microcomputer as shown in FIG.

In the first method, the method includes the following steps S31 to S37.

[0048] Step S31, the switch control module 101 generates a switch off command to control the digital switch 4 to make the voltage difference at the input end of the biosensor circuit 5 zero.

[0049] Step S32, the potentiometer control module 102 generates a first control command to control the contact sliding of the first balancing resistor DR1 of the first digital potentiometer 2 to change the resistance value of the first digital potentiometer.

[0050] Step S33, the potentiometer control module 102 generates a second control command to control the contact sliding of the second balancing resistor DR2 of the second digital potentiometer 3 to change the resistance value of the second digital potentiometer.

[0051] Step S34, the voltage compensation module 103 dynamically adjusts the output terminal voltage of the biosensor circuit 5 according to the resistance value of the first digital potentiometer 2 and the resistance value of the second digital potentiometer 3.

[0052] Step S35, the voltage compensation module 103 detects whether the output voltage of the biosensor circuit 5 is zero.

. If the output voltage of the biosensor circuit 5 is zero, the flow proceeds to step S36; if the output voltage of the biosensor circuit 5 is not zero, the flow returns to step S32.

[0053] Step S36, the potentiometer control module 102 generates a stop command to control the contacts of the first balance resistor DR1 of the first digital potentiometer 2 and the contacts of the second balance resistor DR2 of the second digital potentiometer 3 to stop simultaneously. Slide and fix the position.

[0054] Step S37, the switch control module 101 generates a closing command to control the digital switch 4 to close, so that the potential measurement signal generated by the measuring component 6 passes through the biosensor circuit 5, and detects the accuracy of the potential measurement signal. .

[0055] In this embodiment, a fixed inter-turn interval value (for example, 2 minutes) may be set in the single chip microcomputer 1, and the inter-turn interval value is stored in the memory 12 of the single chip microcomputer 1, when Interval interval value to The microcontroller 11 of the single chip microcomputer 1 automatically performs step S31 to step S37 periodically, that is, performs periodic circuit temperature drift compensation automatically and performs voltage zeroing operation to solve the temperature change and the fixed temperature biosensor. Circuit temperature drift caused by slowly changing circuit 5.

The above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the invention, and the equivalent structure or equivalent function changes made by the description of the present invention and the contents of the drawings, or directly or indirectly applied to other related The technical field is equally included in the scope of patent protection of the present invention.

Embodiments of the invention

The specific embodiments, structures, features and functions of the present invention are described in detail below with reference to the accompanying drawings and preferred embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0058] In order to achieve the object of the present invention, the present invention provides a circuit temperature drift compensation system for a biosensor, which can automatically zero the voltage generated by the biosensor due to the temperature drift of the circuit, thereby reducing the biological temperature drift caused by the circuit. The sensitivity of the sensor affects the accuracy of the circuit temperature drift compensation and the efficiency of the work.

[0060] In this embodiment, the first digital potentiometer 2 includes a first balancing resistor DR1 and a first voltage stabilizing resistor R1, and the second digital potentiometer 3 includes a second balancing resistor DR2 and a second stable Voltage resistor R2. One ends of the first balance resistor DR1 and the first voltage stabilizing resistor R1 are connected to the positive input terminal of the biosensor circuit 5, and the other ends of the first balance resistor DR1 and the first voltage stabilizing resistor R1 are grounded. One ends of the second balancing resistor DR2 and the second voltage stabilizing resistor R2 are connected to the negative input terminal of the biosensor circuit 5, and the other ends of the second balancing resistor DR2 and the second voltage stabilizing resistor R2 are connected to the biosensor circuit 5. The output. First flat The balance resistor DR1 and the second balance resistor DR2 are respectively connected to the control terminal of the single chip microcomputer 1.

[0061] When the contacts of the first balancing resistor DR1 and the second balancing resistor DR2 slide to the zero-terminal resistance value 吋, generating a higher voltage may damage the biosensor circuit 5, and therefore, the first voltage regulator is used in this embodiment. The resistor R1 and the second voltage stabilizing resistor R2 ensure the stability of the output voltages of the first digital potentiometer 2 and the second digital potentiometer 3. The first voltage stabilizing resistor R1 and the second voltage stabilizing resistor R2 are used to keep the first digital potentiometer 2 and the second digital potentiometer 3 output when the contacts of the first balancing resistor DR1 and the second balancing resistor DR2 slide. The voltage is stabilized, thereby protecting the biosensor circuit 5 from damage due to excessive voltage.

[0062] The digital switch 4 includes a first switch K1 and a second switch K2, the output of the first switch K1 and the output of the second switch 2 are respectively connected to the two inputs of the biosensor circuit 5 The input of the first switch K1 and the input of the second switch 2 are respectively connected to the two outputs of the measuring element 6. The microcontroller 1 controls the first switch K1 and the second switch 吋幵2 to open and close by controlling the control terminal of the digital switch 4. The control terminal b of the digital switch 4 is connected to the control terminal of the microcontroller 1.

[0063]

2 is a schematic diagram of the functional modules of a preferred embodiment of the circuit temperature drift compensation system of the biosensor of the present invention. In the embodiment, the circuit temperature drift compensation system 10 is installed and operated in the single chip microcomputer 1. The single chip microcomputer 1 further includes, but is not limited to, the microcontroller 11 and the memory 12. The circuit temperature drift compensation system 10 includes, but is not limited to, a control module 101, a potentiometer control module 102, and a voltage compensation module 103. The module referred to in the present invention refers to a series of computer program instruction segments which can be executed by the microcontroller 11 of the microcontroller 1 and which can perform a fixed function, which are stored in the memory 12 of the microcontroller 1.

[0065] In this embodiment, the microcontroller 11 can be a microprocessor, a micro control unit (MCU), a signal processing chip, or a signal control unit having a signal control function. The memory 12 can be a read only memory ROM, an electrically erasable memory EEPROM or a flash memory FLASH or the like.

[0066] The switch control module 101 is configured to generate a switch off command to control the digital switch 4 to cause the voltage difference at the input end of the biosensor circuit 5 to be zero.

[0067] The potentiometer control module 102 is configured to generate a first control command to control the contact sliding of the first balancing resistor DR1 in the first digital potentiometer 2 to change the resistance value of the first digital potentiometer, and generate a second control Commanding to control the sliding of the contacts of the second balancing resistor DR2 in the second digital potentiometer 3 to change the second digital potentiometer resistance.

[0068] The voltage compensation module 103 is configured to dynamically adjust the output voltage of the biosensor circuit 5 according to the resistance value of the first digital potentiometer 2 and the resistance value of the second digital potentiometer 3, and to detect the biosensor Is the output voltage of circuit 5 zero?

[0069] When the output voltage of the biosensor circuit 5 is zero, the potentiometer control module 102 is further configured to control the contacts of the first balance resistor DR1 of the first digital potentiometer 2 and the second digital potentiometer 3 Second balance resistance

The contacts of the DR2 stop sliding and fix the position.

[0070] When the output voltage of the biosensor circuit 5 is zero, the switching control module 101 is further configured to generate a closing command to control the closing of the digital switch 4 to pass the potential measuring signal generated by the measuring component 6 The biosensor circuit 5 detects the accuracy of the potential measurement signal.

[0071]

[0072] In order to achieve the object of the present invention, the present invention also provides a circuit temperature drift compensation method for a biosensor

As shown in FIG. 3, FIG. 3 is a flow chart of a preferred embodiment of the circuit temperature drift compensation method of the biosensor of the present invention. In this embodiment, the circuit temperature drift compensation method is applied to the single chip microcomputer as shown in FIG.

In the first method, the method includes the following steps S31 to S37.

[0074] Step S31, the switch control module 101 generates a switch off command to control the digital switch 4 to make the voltage difference at the input end of the biosensor circuit 5 zero.

[0075] Step S32, the potentiometer control module 102 generates a first control command to control the contact sliding of the first balancing resistor DR1 of the first digital potentiometer 2 to change the resistance value of the first digital potentiometer.

[0076] Step S33, the potentiometer control module 102 generates a second control command to control the contact sliding of the second balancing resistor DR2 of the second digital potentiometer 3 to change the resistance value of the second digital potentiometer.

[0077] Step S34, the voltage compensation module 103 dynamically adjusts the output voltage of the biosensor circuit 5 according to the resistance value of the first digital potentiometer 2 and the resistance value of the second digital potentiometer 3.

[0078] Step S35, the voltage compensation module 103 detects whether the voltage of the output end of the biosensor circuit 5 is zero.

. If the output voltage of the biosensor circuit 5 is zero, the flow proceeds to step S36; The output voltage of the circuit 5 is not zero, and the flow returns to step S32.

[0079] Step S36, the potentiometer control module 102 generates a stop command to control the contacts of the first balance resistor DR1 of the first digital potentiometer 2 and the contacts of the second balance resistor DR2 of the second digital potentiometer 3 to stop simultaneously. Slide and fix the position.

[0080] Step S37, the switch control module 101 generates a closing command to control the digital switch 4 to close, so that the potential measurement signal generated by the measuring component 6 passes through the biosensor circuit 5, and detects the accuracy of the potential measurement signal. .

[0081] In this embodiment, a fixed inter-turn interval value (for example, 2 minutes) may be set in the single chip microcomputer 1, and the inter-turn interval value is stored in the memory 12 of the single chip microcomputer 1, when When the interval value reaches 吋, the microcontroller 11 of the single chip microcomputer 1 automatically performs step S31 to step S37 periodically, that is, performs periodic circuit temperature drift compensation automatically and performs voltage zeroing operation to solve the temperature change and The temperature drift of the circuit caused by the slow change of the biosensor circuit 5 at a fixed temperature.

The above are only the preferred embodiments of the present invention, and are not intended to limit the scope of the invention, and the equivalent structure or equivalent function changes made by the description of the present invention and the contents of the drawings, or directly or indirectly applied to other related The technical field is equally included in the scope of patent protection of the present invention.

Industrial applicability

[0083] Compared to the prior art, the circuit temperature drift compensation system and method of the biosensor of the present invention shifts the biosensor due to circuit temperature by controlling the resistance values of the first digital potentiometer and the second digital potentiometer The voltage generated by the phenomenon is automatically zeroed, and the resistance values of the first digital potentiometer and the second digital potentiometer of the biosensor output voltage are adjusted to zero, thereby stabilizing the electrical characteristics of the biosensor output and improving the voltage zeroing. The high accuracy and work efficiency eliminates the adverse effects of circuit temperature drift on the sensitivity of the biosensor.

Claims

Claim

[Claim 1] A circuit temperature drift compensation system for a biosensor, which is applied to a single chip microcomputer, wherein the single chip is connected with a first digital potentiometer, a second digital potentiometer, and a digital switch, the digital key is off The two output terminals are respectively connected to two input ends of the biosensor circuit, and the output end of the biosensor circuit is connected to the single chip microcomputer, wherein the circuit temperature drift compensation system comprises: a control module for generating a switch off command to control the digital switch off to make the voltage difference of the input end of the biosensor circuit zero; a potentiometer control module, configured to generate a first control command to control the first balance resistor in the first digital potentiometer The contact slides to change the resistance value of the first digital potentiometer, and generates a second control command to control the contact sliding of the second balance resistor in the second digital potentiometer to change the resistance value of the second digital potentiometer; the voltage compensation module, For dynamically adjusting the resistance according to the resistance value of the first digital potentiometer and the resistance value of the second digital potentiometer The output voltage of the sensor circuit, and the actual detection of the output voltage of the biosensor circuit is zero; when the output voltage of the biosensor circuit is zero, the potentiometer control module is further used to control the first The contacts of the first balancing resistor of the digital potentiometer and the contacts of the second balancing resistor of the second digital potentiometer stop sliding and fix the position.

[Claim 2] The circuit temperature drift compensation system of the biosensor according to claim 1, wherein the two input terminals of the digital switch are respectively connected to two output ends of the measuring component, the The control module is further configured to: when the output voltage of the biosensor circuit is zero, generate a 幵 closing command to control the digital 幵 closing so that the potential measurement signal generated by the measuring component passes through the biosensor circuit and detects the potential measurement The accuracy of the signal.

[Claim 3] The circuit temperature drift compensation system of the biosensor of claim 1, wherein the first digital potentiometer comprises a first voltage stabilizing resistor, and the second digital potentiometer comprises a second stable a first resistor and a second voltage regulator are used to keep the first digital potentiometer and the second digital potentiometer output stable when the contacts of the first balance resistor and the second balance resistor are slid Voltage.

[Claim 4] The circuit temperature drift compensation system of the biosensor according to claim 3, wherein one end of the first balance resistor and the first voltage stabilizing resistor is connected to the biosensor circuit a positive input terminal, the first balance resistor and the other end of the first voltage stabilizing resistor are grounded, and one end of the second balance resistor and the second voltage stabilizing resistor is connected to a negative input terminal of the biosensor circuit, the second balance resistor The other end of the second voltage stabilizing resistor is connected to the output of the biosensor circuit.

The circuit temperature drift compensation system of the biosensor according to any one of claims 1 to 4, wherein the control terminals of the first balance resistor, the second balance resistor and the digital switch are respectively connected to the single chip microcomputer Control terminal.

A circuit temperature drift compensation method for a biosensor is applied to a single chip microcomputer, wherein the single chip is connected with a first digital potentiometer, a second digital potentiometer and a digital switch, and the two outputs of the digital switch are connected Connected to two inputs of the biosensor circuit, the output of the biosensor circuit is connected to the single chip, the circuit temperature drift compensation method comprises the steps of: generating a switch off command to control the digital switch off幵 causing the input voltage difference of the biosensor circuit to be zero; generating a first control command to control the contact slip of the first balance resistor in the first digital potentiometer to change the resistance value of the first digital potentiometer; generating a second control command control The contact of the second balance resistor in the second digital potentiometer slides to change the resistance value of the second digital potentiometer; dynamically adjusts the output of the biosensor circuit according to the resistance value of the first digital potentiometer and the resistance value of the second digital potentiometer Terminal voltage; detecting whether the voltage at the output end of the biosensor circuit is zero; The output of the voltage zero inches biosensor circuit, a second contact of the first balancing resistor control digital potentiometer balancing a first contact and a second resistance of the digital potentiometer with a sliding stop and a fixed position inch.

The circuit temperature drift compensation method of the biosensor according to claim 6, wherein the two input terminals of the digital switch are respectively connected to two output ends of the measuring component, and the circuit temperature drift compensation method further comprises Step: when the output voltage of the biosensor circuit is zero, generating a 幵 closing command to control the digital 幵 closing and causing the potential measuring signal generated by the measuring component to pass through the biosensor circuit and detecting the accuracy of the potential measuring signal degree.

A circuit temperature drift compensation method for a biosensor according to claim 6, characterized in that The first digital potentiometer includes a first voltage stabilizing resistor, the second digital potentiometer includes a second voltage stabilizing resistor, and the first voltage stabilizing resistor and the second voltage stabilizing resistor are used to be the first The balance resistor and the contact of the second balance resistor slide to maintain a stable voltage of the first digital potentiometer and the second digital potentiometer.

[Claim 9] The circuit temperature drift compensation method of the biosensor according to claim 8, wherein one end of the first balance resistor and the first voltage stabilizing resistor is connected to a positive input terminal of the biosensor circuit, The other end of the first balancing resistor and the first voltage stabilizing resistor is grounded, and one end of the second balancing resistor and the second voltage stabilizing resistor is connected to a negative input terminal of the biosensor circuit, the second balancing resistor and the second voltage stabilizing resistor The other end is connected to the output of the biosensor circuit.

[Claim 10] The circuit temperature drift compensation method of the biosensor according to any one of claims 6 to 9, wherein the first balance resistor, the second balance resistor, and the digital control terminal are respectively connected To the control end of the microcontroller.