WO2017083931A1 - Technique non chirurgicale de rajeunissement vulvo-vaginal et dispositif d'injection à cet effet - Google Patents

Technique non chirurgicale de rajeunissement vulvo-vaginal et dispositif d'injection à cet effet Download PDF

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Publication number
WO2017083931A1
WO2017083931A1 PCT/AU2016/051121 AU2016051121W WO2017083931A1 WO 2017083931 A1 WO2017083931 A1 WO 2017083931A1 AU 2016051121 W AU2016051121 W AU 2016051121W WO 2017083931 A1 WO2017083931 A1 WO 2017083931A1
Authority
WO
WIPO (PCT)
Prior art keywords
injecting
technique
discrete locations
vulvovaginal
rich plasma
Prior art date
Application number
PCT/AU2016/051121
Other languages
English (en)
Inventor
Abbas AL-TAIFF
Original Assignee
Al-Taiff Abbas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015904779A external-priority patent/AU2015904779A0/en
Application filed by Al-Taiff Abbas filed Critical Al-Taiff Abbas
Publication of WO2017083931A1 publication Critical patent/WO2017083931A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes

Definitions

  • the present invention relates to non-surgical vulvovaginal rejuvenation technique and an injecting device therefor.
  • a non-surgical vulvovaginal rejuvenation technique comprising extracting blood from a female patient; extracting platelet rich plasma from the blood; and applying the platelet rich plasma to the vulvovaginal area of the patient.
  • the vulvovaginal area may comprise at least the vaginal wall of the patient.
  • Applying the platelet rich plasma may comprise applying the platelet rich plasma with a brush.
  • Extracting the platelet rich plasma may comprise centrifugal separation.
  • Applying the platelet rich plasma to the vaginal wall may comprise injecting the platelet rich plasma into the vaginal wall.
  • Injecting may comprise injecting the platelet rich plasma into an interior circumference of the vaginal wall.
  • Injecting may comprise injecting the platelet rich plasma at a plurality of discrete locations at differing locations around the interior circumference of the vaginal wall.
  • Injecting may comprise injecting the platelet rich plasma at the plurality of discrete locations substantially simultaneously.
  • Injecting may comprise injecting the platelet rich plasma at the plurality of discrete locations sequentially.
  • the plurality of discrete locations may comprise at least four discrete locations.
  • the plurality of discrete locations may comprise at least six discrete locations.
  • Injecting may comprise injecting the platelet rich plasma at a plurality of discrete locations at differing depths within the vagina.
  • the plurality of discrete locations may comprise at least three discrete locations.
  • the plurality of discrete locations may comprise at least four discrete locations.
  • the technique further may comprise the calculation of a post-application rejuvenation score in accordance with an assessment and repeating the application of the platelets rich plasma in accordance with a treatment regime determined by the post-application rejuvenation score.
  • the treatment regime may comprise successive application substantially every four weeks.
  • the treatment regime may comprise three to six applications.
  • the assessment may be a physical examination assessment.
  • the score rates at least one of the appearance and elasticity of the Genital Hill/Mons Pubis, vaginal orifice and clitoris.
  • the assessment may comprise a patient questionnaire.
  • the questionnaire may comprise questions relating to at least one of frequency of sexual contact, time to reach orgasm, level of arousal, own satisfaction and partner's satisfaction
  • the technique may comprise inserting a substantially elongate injecting device into the vagina and wherein the injecting device may comprise at least one hypodermic needle orientated in a lateral direction substantially perpendicular the elongate axis of the injecting device.
  • the injecting device may be substantially cylindrical.
  • the injecting device may comprise a diameter selected for accommodation within a vagina.
  • an injecting device for non-surgical vulvovaginal rejuvenation the device being substantially elongate and configured for insertion into a vagina
  • the device comprising a chamber for a vulvovaginal rejuvenator; and a plurality of hypodermic needles operably coupled to the chamber, wherein, in use, the plurality of hypodermic needles are adapted for extending substantially laterally to the elongate axis of the device for injecting the vulvovaginal rejuvenator into an interior circumference of the vaginal wall.
  • the plurality of hypodermic needles are configurable in a retracted configuration suited for the insertion of the device into the vagina and an extended configuration for the injection of the vulvovaginal rejuvenator.
  • the hypodermic needles are bendable hypodermic needles.
  • the distal ends of the hypodermic needles are adapted to transition from a first trajectory substantially in line with the elongate axis of the device to a second trajectory away from the elongate axis of the device.
  • hypodermic needles are adapted to assume the extended configuration prior to the delivery of the vulvovaginal rejuvenator.
  • the injecting device may further comprise a plunger operably coupled to the chamber and wherein, in use, the plunger may be adapted to act on the hypodermic needles to transition the hypodermic needles to the extended configuration.
  • the plunger may be adapted to subsequently act to expel the vulvovaginal rejuvenator through the hypodermic needles in the extended configuration.
  • the injecting device may further comprise a cervical shield.
  • the plurality of hypodermic needles are adapted for injecting the vulvovaginal rejuvenator at a plurality of discrete locations at differing locations around the interior circumference of the vaginal wall.
  • the plurality of hypodermic needles are adapted for injecting the vulvovaginal rejuvenator at the plurality of discrete locations substantially simultaneously.
  • the plurality of discrete locations may comprise at least four discrete locations.
  • the plurality of discrete locations may comprise at least six discrete locations.
  • the plurality of hypodermic needles are adapted for injecting the vulvovaginal rejuvenator at a plurality of discrete locations at differing depths within the vagina.
  • the plurality of discrete locations may comprise at least three discrete locations.
  • the plurality of discrete locations may comprise at least four discrete locations.
  • Figure 1 shows an injecting device for non-surgical vulvovaginal rejuvenation in accordance with an embodiment of the present disclosure
  • Figure 2 shows top views of the injecting device of Figure 1 in accordance with an embodiment of the present disclosure.
  • the female genital (Vulvovaginal) area appearance and function can be affected by many factors related to age, pregnancy, trauma and hormonal factors. Female genital appearance dissatisfaction may lead to deterioration of self-esteem, poor sexual desire and/ or ultimately a frustrating non-orgasmic experience which may affect both partners.
  • the technique comprises the use of female's own blood, the separation and extraction of Platelet Rich Plasma (PRP) from the blood to be injected point by point into multiple sites of the vulvovaginal area under sterile environment.
  • PRP Platelet Rich Plasma
  • the technique may be repeated every 4 weeks for 3-6 sessions depending on the levels of improvement and satisfaction.
  • the inventor has further discovered from post-application patient questionnaires that the technique disclosed herein surprisingly improves frequency of sexual contact, time to reach orgasm, level of arousal, own satisfaction and partner's satisfaction.
  • the technique specifically comprises extracting blood from a female patient, extracting the platelet rich plasma from the blood and applying the platelet rich plasma to the vulvovaginal area of the patient.
  • the platelet rich plasma may be extracted from the blood utilising centrifugal separation.
  • the platelet rich plasma may be applied to the differing areas of the vulvovaginal area of the patient.
  • the platelet rich plasma may be applied to differing areas of the vulva such as the mons pubis; the labia, consisting of the labia majora and the labia minora; the external portion of the clitoris, consisting of the clitoral glans and the clitoral hood and the vaginal orifice (opening of the vagina)
  • the platelet rich plasma may be applied to the vaginal wall including the Grafenberg gland and/or G-spot.
  • applying the platelet rich plasma comprises injecting the platelet rich plasma.
  • the plasma may be injected utilising the below described injecting device.
  • the technique may comprises injecting the platelet rich plasma into the vaginal wall.
  • the injection may comprise injecting the plasma into an interior circumference of the vaginal wall at discrete locations around the interior circumference of the vaginal wall.
  • the injection may comprise injecting the plasma at the discrete locations substantially simultaneously.
  • the injecting device utilised in one embodiment may allow for the substantial injection of the plasma simultaneously.
  • the simultaneous injection of the plasma at discrete locations advantageously reduces the application time of the plasma.
  • the injection of the plasma may comprise injecting the plasma at discrete locations around the interior circumference of the vaginal wall and also at differing discrete depths within the vagina.
  • the injecting device may simultaneously inject plasma at differing locations along the interior circumference of the vaginal wall and at differing depths along the vagina.
  • the technique may further comprise a calculation of a post- application rejuvenation score in accordance with an assessment and repeating the application of the platelet rich plasma in accordance with a treatment regime determined by the post-application rejuvenation score.
  • the assessment may comprise a visual assessment.
  • the table below represents differing criteria that may be utilised for the purposes of the assessment: PRP Treatment for Vulvovaginal Rejuvenation
  • the assessment comprises a physical examination assessment wherein the appearance and/or elasticity of the Genital Hill/Mons Pubis, vaginal orifice and clitoris is assessed by a practitioner or the patient.
  • the assessment may comprise patient provided answers to a questionnaire.
  • the patient may be provided with a multiple choice answer questionnaire comprising questions relating to frequency of sexual contact, time to reach orgasm, level of arousal, own satisfaction and partner's satisfaction.
  • the further applications of platelet rich plasma may be provided in accordance with the rejuvenation score. For example, treatment may continue until such time that a satisfactory score threshold is achieved.
  • the treatment regime may comprise 3 to 6 applications of plasma substantially every four weeks.
  • FIG 1 there is shown an injecting device 1 for nonsurgical vulvovaginal rejuvenation.
  • the device 1 may be utilised for injecting vulvovaginal rejuvenators, such as the platelet rich plasma as described above.
  • the device 1 is configured for use for injecting the vulvovaginal rejuvenator into an interior circumference of the vaginal wall.
  • the device 1 comprises a chamber 6 for the vulvovaginal rejuvenator. Furthermore, the device 11 comprises a plurality of hypodermic needles 3 operably coupled to the chamber 6. As such, in use, the plurality of hypodermic needles 6 are adapted for extending substantially laterally to the elongate axis of the device 1 for injecting the vulvovaginal rejuvenator into an interior circumference of the vaginal wall.
  • the plurality of hypodermic needles 6 are configurable in a retracted configuration suited for the insertion of the device 1 into the vagina and an extended configuration for injection of the vulvovaginal rejuvenator into an interior circumference of the vaginal wall.
  • figure 1A shows the hypodermic needles 3 in the retracted configuration
  • figure IB show the hypodermic needles 3 in the extended configuration.
  • the device 1 is configured in the retracted configuration as substantially shown in figure 1A for the insertion of the device 1 into the vagina and the removal therefrom and configured in the extended configuration as substantially shown in figure IB for the injection of the vulvovaginal rejuvenator.
  • the distal end of the device 1 may comprise a cervical shield 2 to protect the cervix of the patient.
  • the device 1 may be inserted until such time that the cervical shield 2 abuts against the cervix.
  • figure 2A shows the top view of the device 1 in the retracted configuration prior to insertion into the vagina.
  • the device 1 is configured into the extended configuration wherein the needles 3 extend laterally into the vaginal wall for the injection of the vulvovaginal rejuvenator.
  • the device 1 is configured again into the retracted configuration as is shown in figure 2C for the withdrawal from the vagina.
  • the hypodermic needles 3 are bendable hypodermic needles 3.
  • the distal ends of the hypodermic needles 3 are adapted to transition from a first trajectory substantially in line with the elongate axis of the device 1 to a second trajectory away from the elongate axis of the device 1.
  • the hypodermic needles 3 are adapted to assume the extended configuration prior to the delivery of the vulvovaginal rejuvenator.
  • the chamber 6 is defined by the plunger 7 tip at the lower end and a plate 8 at the upper end.
  • the vulvovaginal rejuvenator within the chamber 6 is pressurised so as to act upon the plate 8 to move the plate 8 upwards.
  • the plate 8 in turn acts upon spring 5 and a spacer 9 fastened to upper plate 4 to cause the applicant 4 to bear against the hypodermic needles 3 to cause the hypodermic needles 3 to assume the extended configuration.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne une technique non chirurgicale de rajeunissement vulvo-vaginal et un dispositif d'injection à cet effet. La technique peut consister à prélever du sang chez une patiente ; à extraire du plasma riche en plaquettes du sang ; et à administrer le plasma riche en plaquettes au niveau de la zone vulvo-vaginale de la patiente. En outre, le dispositif peut être sensiblement allongé et conçu pour être inséré dans le vagin. Le dispositif peut comprendre une chambre pour régénérateur vulvo-vaginal ; et de multiples aiguilles hypodermiques en liaison fonctionnelle avec la chambre. Lors de l'utilisation, les multiples aiguilles hypodermiques sont conçues pour se prolonger sensiblement latéralement à l'axe allongé du dispositif pour l'injection du régénérateur vulvo-vaginal dans le périmètre intérieur de la paroi vaginale.
PCT/AU2016/051121 2015-11-19 2016-11-18 Technique non chirurgicale de rajeunissement vulvo-vaginal et dispositif d'injection à cet effet WO2017083931A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2015904779A AU2015904779A0 (en) 2015-11-19 A non-surgical vulvovaginal rejuvenation technique and an injecting device therefor
AU2015904779 2015-11-19

Publications (1)

Publication Number Publication Date
WO2017083931A1 true WO2017083931A1 (fr) 2017-05-26

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018071875A1 (fr) * 2016-10-14 2018-04-19 Eclipse Aesthetics, LLC Dispositif pré-administration pour resserrement vaginal

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066199A1 (fr) * 1999-04-29 2000-11-09 Precision Vascular Systems, Inc. Appareil permettant d'injecter des fluides dans des parois de vaisseaux sanguins, de cavites corporelles, et analogues
US6217554B1 (en) * 1999-02-12 2001-04-17 Pharmaspec Corporation Methods and apparatus for delivering substances into extravascular tissue
WO2002058768A1 (fr) * 2001-01-05 2002-08-01 University Of Dundee Aiguille hypodermique amelioree et dispositif d'injection de fluide
WO2006118804A1 (fr) * 2005-04-29 2006-11-09 Warsaw Orthopedic, Inc. Dispositifs d'administration d'agents medicamenteux
WO2012038959A2 (fr) * 2010-09-21 2012-03-29 Israel Shamir Lebovitz Aiguille multi-directionnelle
WO2013007308A1 (fr) * 2011-07-14 2013-01-17 Garbin Stefania Composition de plasma riche en plaquettes pour la réparation et la régénération tissulaire

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217554B1 (en) * 1999-02-12 2001-04-17 Pharmaspec Corporation Methods and apparatus for delivering substances into extravascular tissue
WO2000066199A1 (fr) * 1999-04-29 2000-11-09 Precision Vascular Systems, Inc. Appareil permettant d'injecter des fluides dans des parois de vaisseaux sanguins, de cavites corporelles, et analogues
WO2002058768A1 (fr) * 2001-01-05 2002-08-01 University Of Dundee Aiguille hypodermique amelioree et dispositif d'injection de fluide
WO2006118804A1 (fr) * 2005-04-29 2006-11-09 Warsaw Orthopedic, Inc. Dispositifs d'administration d'agents medicamenteux
WO2012038959A2 (fr) * 2010-09-21 2012-03-29 Israel Shamir Lebovitz Aiguille multi-directionnelle
WO2013007308A1 (fr) * 2011-07-14 2013-01-17 Garbin Stefania Composition de plasma riche en plaquettes pour la réparation et la régénération tissulaire

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIRJALAL, A.: "Hit me with your best O-shot", IOL, 10 October 2014 (2014-10-10), XP055383132, Retrieved from the Internet <URL:http://www.iol.co.za/lifestyle/love-sex/sex/hit-me-with-your-best-o-shot-1763019> [retrieved on 20170328] *
EARLE, C.: "Five-minute jab 'down there' gave our sex lives huge boost", THE SUN, 3 October 2015 (2015-10-03), XP055383126, Retrieved from the Internet <URL:https://www.thesun.co.uk/archives/health/214015/five-minute-jab-down-there-gave-our-sex-lives-huge-boost> [retrieved on 20170328] *
RUNELS, C. ET AL.: "A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the treatment of Female Sexual Dysfunction", JOURNAL OF WOMEN'S HEALTH CARE., vol. 3, no. 4, 2014, pages 1 - 4, XP055383121, ISSN: 2167-0420 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018071875A1 (fr) * 2016-10-14 2018-04-19 Eclipse Aesthetics, LLC Dispositif pré-administration pour resserrement vaginal

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