WO2017057677A1 - Cosmétique d'écran solaire - Google Patents

Cosmétique d'écran solaire Download PDF

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Publication number
WO2017057677A1
WO2017057677A1 PCT/JP2016/079012 JP2016079012W WO2017057677A1 WO 2017057677 A1 WO2017057677 A1 WO 2017057677A1 JP 2016079012 W JP2016079012 W JP 2016079012W WO 2017057677 A1 WO2017057677 A1 WO 2017057677A1
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WO
WIPO (PCT)
Prior art keywords
mass
ultraviolet
present
octocrylene
spf
Prior art date
Application number
PCT/JP2016/079012
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English (en)
Japanese (ja)
Inventor
松井　隆
太一 原田
Original Assignee
株式会社 資生堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2016077552A external-priority patent/JP6143914B2/ja
Application filed by 株式会社 資生堂 filed Critical 株式会社 資生堂
Priority to CN201680057322.7A priority Critical patent/CN108135817B/zh
Priority to BR112018006175A priority patent/BR112018006175A2/pt
Priority to US15/762,452 priority patent/US10328004B2/en
Priority to EP16851846.2A priority patent/EP3357485A4/fr
Priority to KR1020187007899A priority patent/KR102606444B1/ko
Publication of WO2017057677A1 publication Critical patent/WO2017057677A1/fr
Priority to HK18113674.6A priority patent/HK1254690A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/415—Aminophenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

  • the present invention relates to a sunscreen cosmetic. More specifically, sunscreen cosmetics exhibiting high UV protection ability in a wide wavelength range from UVA to UVB and having excellent stability even if the blending amount of UV absorbers that have been widely used in the past is reduced. About.
  • Sunscreen cosmetics a type of UV care cosmetics, absorb or scatter UVA and UVB on the skin by covering the skin with a coating film containing a UV absorber or UV scattering agent. It is a cosmetic intended to suppress the amount of ultraviolet rays to reach and protect the skin from the harm of ultraviolet rays (Non-patent Document 1).
  • Ethylhexyl methoxycinnamate and octocrylene (2-cyano-3,3-diphenylprop-2-enoic acid-2-ethylhexyl) are conventional sunscreen cosmetics as liquid UV absorbers having an absorption wavelength mainly in the UVB region. It was widely used. However, these UV absorbers may irritate the skin of users with sensitive skin. For example, skin external preparations have been proposed in which the stimulation of ethylhexyl methoxycinnamate is mitigated by blending with polypropylene glycol dimethyl ether. (Patent Document 1).
  • Patent Document 2 discloses a so-called non-chemical sunscreen cosmetic that does not contain ethylhexyl methoxycinnamate, octocrylene, and avobenzone, but contains a combination of a plurality of powder components having an ultraviolet scattering effect, and is applied to the face. In some cases, cosmetics that do not irritate the eyes are obtained. However, in order to obtain a high UV protection effect (high SPF) with only the powder component, it is necessary to add a large amount of the powder component, and unnatural whiteness may occur when applied to the skin.
  • high SPF high UV protection effect
  • organic ultraviolet absorbers other than ethylhexyl methoxycinnamate and octocrylene are solid at room temperature.
  • liquid ethylhexyl methoxycinnamate and octocrylene also played a role as a solvent, and no problem occurred.
  • the problem in the present invention is that even if the amount of liquid UV absorbers such as ethylhexyl methoxycinnamate and octocrylene is suppressed, a high UV protection effect is exhibited, and it is stable and excellent in usability, and does not become unnaturally whitened when applied. It is to provide stop cosmetics.
  • the present inventors have combined a specific solid ultraviolet absorber and a specific oil component to achieve a high ultraviolet protective effect even if the mixing of the liquid ultraviolet absorber is suppressed.
  • the present inventors have found that a low-irritant sunscreen cosmetic that is excellent in stability and usability and that does not become unnaturally whitened upon application can be obtained.
  • the present invention (A) 0.5-10.0% by weight of t-butylmethoxydibenzoylmethane and / or hexyl diethylaminohydroxybenzoylbenzoate; (B) 0.5 to 5.0% by weight of bisethylhexyloxyphenol methoxyphenyl triazine; (C) 0.5 to 5.0% by weight of ethylhexyltriazone; (D) 5 to 50% by mass of an ester oil having a solubility at 25 ° C.
  • the total blending amount of the components (A), (B) and (C) is 1.5 to 15% by mass, and the blending amount of ethylhexyl methoxycinnamate and octocrylene is 3% by mass or less.
  • the sunscreen cosmetics of the present invention exhibit a high UV protection effect by a combination of specific solid UV absorbers, even if the amount of liquid UV absorbers ethylhexyl methoxycinnamate and octocrylene is suppressed or not added, and A low-irritant sunscreen cosmetic that is stable and excellent in usability and does not become unnaturally whitened when applied.
  • an appropriate amount of a powder (ultraviolet scattering agent) having an ultraviolet scattering effect was blended with the sunscreen cosmetic of the present invention, an unexpected effect that the SPF was synergistically improved was obtained.
  • each compounding quantity of the said component (A), (B), (C) and (E) was adjusted to the specific ratio, the well-balanced ultraviolet-ray protective effect was able to be acquired in the wavelength range of UVA and UVB.
  • the sunscreen cosmetic of the present invention comprises (A) t-butylmethoxydibenzoylmethane and / or hexyl diethylaminohydroxybenzoyl benzoate, (B) bisethylhexyloxyphenol methoxyphenyltriazine, which are solid UV absorbers at room temperature, and (C) It contains ethylhexyltriazone as an essential component.
  • t-butylmethoxydibenzoylmethane and / or hexyl diethylaminohydroxybenzoyl benzoate t-butylmethoxydibenzoylmethane is a kind of benzophenone-based UV absorber having a maximum absorption wavelength in the UVA region. Widely used.
  • the t-butylmethoxydibenzoylmethane used in the present invention may be a commercially available product, and examples thereof include those commercially available from DSM Nutrition Japan Co., Ltd. under the name “Pulsol 1789”.
  • Diethylaminohydroxybenzoyl hexyl benzoate is a kind of paraaminobenzoic acid (PABA) ultraviolet absorber having a maximum absorption wavelength in the UVA region.
  • PABA paraaminobenzoic acid
  • the hexyl diethylaminohydroxybenzoyl benzoate used by this invention may be a commercial item, for example, what is marketed from BASF Japan Ltd. by the name of "Ubinal A plus" can be illustrated.
  • the component (A) in the sunscreen cosmetic of the present invention may contain one or both of t-butylmethoxydibenzoylmethane and hexyl diethylaminohydroxybenzoylbenzoate.
  • the total amount of t-butylmethoxydibenzoylmethane and diethylaminohydroxybenzoyl hexyl benzoate is 0.5 to 10% by mass, preferably 1 to 9% by mass, more preferably 2 to 8% by mass.
  • Bisethylhexyloxyphenol methoxyphenyl triazine is a kind of triazine-based ultraviolet absorber, and has a characteristic of absorbing ultraviolet rays in a wide wavelength range from UVA to UVB, and has high light stability. It is known to have sex.
  • the bisethylhexyloxyphenol methoxyphenyl triazine used in the present invention may be a commercially available product, for example, those commercially available from BASF Japan Ltd. under the name “Tinosorb S”.
  • the blending amount of component (B), that is, bisethylhexyloxyphenol methoxyphenyl triazine in the sunscreen cosmetic of the present invention is 0.5 to 5% by mass, preferably 0.6 to 3% by mass, more preferably 0.00%. 7-2% by mass.
  • the ethylhexyl triazone used in the present invention may be a commercially available product, and examples thereof include those commercially available from BASF Japan Ltd. under the name “Ubinal T150”.
  • the amount of component (C), that is, ethylhexyltriazone in the sunscreen cosmetic of the present invention is 0.5 to 5% by mass, preferably 0.7 to 4% by mass, more preferably 0.8 to 3% by mass. %.
  • the total blending amount of the components (A), (B) and (C) (hereinafter sometimes referred to as “specific solid ultraviolet absorber”) is 1.5 to 15. % By mass, preferably 3 to 14% by mass, more preferably 5 to 12% by mass, and most preferably 6 to 10% by mass.
  • the total blending amount is less than 1.5% by mass, sufficient UV protection ability (for example, SPF15 or more) cannot be obtained, and when it exceeds 15% by mass, crystal precipitation may occur.
  • the sunscreen cosmetic of the present invention it is more preferable to adjust so that the difference in the blending amounts of the components (A), (B) and (C) is within 4% by mass.
  • the component (D) used in the present invention is an ester oil, and the solubility of each of the components (A), (B), and (C) in the ester oil at 25 ° C. is 10% (weight / weight).
  • the ester oil of component (D) may hereinafter be referred to as “specific ester oil”).
  • ester oils used in the present invention include diisopropyl sebacate, diethylhexyl succinate, glyceryl tri-2-ethylhexanoate, pentaerythrityl tetra-2-ethylhexanoate, cetyl 2-ethylhexanoate, carbon number 12 1 to 2 or more of ⁇ 15 alkylbenzoates and isonononyl isononanoate.
  • diisopropyl sebacate and / or diethylhexyl succinate are used.
  • the blending amount of the specific ester oil (component (D)) in the sunscreen cosmetic of the present invention is 5 to 50% by mass, preferably 8 to 45% by mass, more preferably 10 to 40% by mass. If the blending amount is less than 5% by mass, a part of the specific solid ultraviolet absorber may be precipitated, and even if the blending amount exceeds 50% by mass, no further improvement in the characteristics is recognized. From the viewpoint of cosmetic stability, the ratio of the specific ester oil (D) to the total amount of the specific solid ultraviolet absorbers (components (A), (B) and (C)) ([[ (A) + (B) + (C)] / (D)) is preferably 1/2 or less, more preferably 1/3 or less, and even more preferably 1/5 or less.
  • a sufficiently high UV protection ability (for example, SPF 15 or higher) is achieved by combining the specific solid UV absorbers ((A), (B) and (C).
  • the specific ester oil is blended together, the problem of precipitation of the solid ultraviolet absorber does not occur, so that the liquid ultraviolet absorber that has been blended in the conventional sunscreen cosmetics, that is, methoxysilicate. It is possible to suppress the blending amount of ethyl hexyl and octocrylene.
  • the total amount of ethylhexyl methoxycinnamate and octocrylene in the sunscreen cosmetic of the present invention is 3% by mass or less, preferably 2% by mass or less, more preferably 1% by mass. Furthermore, the sunscreen cosmetic of the present invention includes an embodiment that does not contain ethylhexyl methoxycinnamate and octocrylene.
  • the sunscreen cosmetic of the present invention contains, as a component (E), a powder (ultraviolet scattering agent) that physically shields ultraviolet rays by reflection / scattering.
  • the ultraviolet scattering agent used in the present invention is not particularly limited as long as it is a powder used as an ultraviolet scattering agent in the cosmetic field. Specific examples include one selected from titanium oxide, zinc oxide, barium sulfate, iron oxide, talc, mica, sericite, kaolin, titanium mica, bitumen, chromium oxide, chromium hydroxide, silica, cerium oxide, and the like. Two or more types can be mentioned. In particular, it is preferable from the viewpoint of optical properties to use a powder having a refractive index of 1.5 or more, such as zinc oxide or titanium oxide.
  • the ultraviolet light scattering agent subjected to the surface hydrophobicity treatment is also preferably used.
  • Surface treatment methods include silicone treatment such as methylhydrogenpolysiloxane and methylpolysiloxane; alkylsilane treatment; fluorine treatment with perfluoroalkyl phosphate ester, perfluoroalcohol, etc .; amino acid treatment with N-acyl glutamic acid, etc. And lecithin treatment; metal soap treatment; fatty acid treatment; alkyl phosphate ester treatment and the like.
  • the ultraviolet scattering agent used by this invention is not specifically limited, Usually, an average primary particle diameter of 100 nm or less is preferable, More preferably, it is 80 nm or less. When the average primary particle size greatly exceeds 100 nm, there is a tendency to cause white floating or white residue.
  • the average primary particle diameter in this invention is a value calculated
  • the particle shape of the ultraviolet light scattering agent is not particularly limited, and may be in the form of primary particles or may form an aggregated secondary aggregate. Further, the shape such as a spherical shape, an elliptical shape, and a crushed shape is not particularly limited.
  • the blending amount of the ultraviolet light scattering agent in the sunscreen cosmetic of the present invention is 1.5 to 12% by mass, preferably 2 to 10% by mass, and most preferably 2 to 6% by mass.
  • the UV protection effect obtained when the blending amount is less than 1.5% by mass is not sufficient, and when blending exceeding 12% by mass, the whiteness at the time of application becomes noticeable, and a powdery feeling of use may occur. is there.
  • a high UV protection effect is obtained by blending the components (A), (B), (C) and (E), but the total of the components (C) and (E).
  • a high SPF can be achieved by adjusting the blending amount to 8% by mass or more.
  • the sunscreen cosmetic of the present invention is in addition to the essential components of the specific solid ultraviolet absorber ((A), (B) and (C)), the specific ester oil (D) and the ultraviolet scattering agent (E). Further, other optional components that can be usually blended in sunscreen cosmetics may be included within a range that does not impair the effects of the present invention.
  • UV absorbers other than the specific solid ultraviolet absorber excluding ethylhexyl methoxycinnamate and octocrylene
  • UVA and / or UVB regions Can further improve the UV protection ability.
  • the ultraviolet absorbers other than the specific solid ultraviolet absorbers ((A), (B) and (C)) can be selected from those usually used in cosmetics and are not particularly limited.
  • para-aminobenzoic acid derivatives for example, para-aminobenzoic acid derivatives, salicylic acid derivatives, cinnamic acid derivatives, ⁇ , ⁇ -diphenyl acrylate derivatives, benzophenone derivatives, benzylidene camphor derivatives, phenylbenzimidazole derivatives, triazine derivatives, phenylbenzotriazole derivatives, anthranyl derivatives, imidazoline derivatives And one or more selected from benzalmalonate derivatives, 4,4-diarylbutadiene derivatives and the like.
  • Other optional components include water-soluble polymers, oil-soluble polymers, waxes, alcohols, hydrocarbon oils, fatty acids, higher alcohols, fatty acid esters, silicone oils, surfactants, powder components other than UV scattering agents, Although a medicine etc. are mentioned, it is not limited to these illustrations.
  • water-soluble polymer examples include homopolymers or copolymers of 2-acrylamido-2-methylpropanesulfonic acid (hereinafter abbreviated as “AMPS”).
  • the copolymer is a copolymer composed of a comonomer such as vinyl pyrrolidone, acrylic acid amide, sodium acrylate, or hydroxyethyl acrylate. That is, an AMPS homopolymer, a vinylpyrrolidone / AMPS copolymer, a dimethylacrylamide / AMPS copolymer, an acrylic amide / AMPS copolymer, a sodium acrylate / AMPS copolymer, and the like are exemplified.
  • carboxyvinyl polymer ammonium polyacrylate, sodium polyacrylate, sodium acrylate / alkyl acrylate / sodium methacrylate / alkyl methacrylate copolymer, carrageenan, pectin, mannan, curdlan, chondroitin sulfate, starch, Glycogen, gum arabic, sodium hyaluronate, tragacanth gum, xanthan gum, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, chitin, chitosan, carboxymethyl chitin, agar etc. Illustrated.
  • oil-soluble polymer examples include trimethylsiloxysilicic acid, alkyl-modified silicone, polyamide-modified silicone, dimethicone crosspolymer, (dimethicone / vinyl dimethicone) crosspolymer, polymethylsilsesquioxane, and the like.
  • waxes examples include beeswax, candelilla wax, carnauba wax, lanolin, liquid lanolin, jojoba wax and the like.
  • alcohols examples include lower alcohols such as ethanol and isopropanol, and polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, and polybutylene glycol.
  • hydrocarbon oil examples include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, polyethylene wax, and Fischer-Tropsch wax.
  • fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, arachidonic acid and the like.
  • Higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, aralkyl alcohol, batyl alcohol, chimyl alcohol, carnervir alcohol, ceryl alcohol, coryranyl alcohol, myricyl alcohol, lacteryl alcohol, elayl
  • Illustrative examples include diol alcohol, isostearyl glyceryl ether, octyl alcohol, triacontyl alcohol, ceralkyl alcohol, cetostearyl alcohol, oleyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, isostearyl alcohol, hexyldecanol, octyldecanol and the like.
  • silicone oils examples include methylpolysiloxane, octamethylsiloxane, decamethyltetrasiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, hexamethylcyclotrisiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and the like. be able to.
  • Preferred examples include octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane.
  • surfactant examples include anionic, cationic, nonionic, and amphoteric surfactants, and include silicone-based or hydrocarbon-based surfactants.
  • powder components other than the ultraviolet light scattering agent (component E) include nylon and acrylic polymer spherical powder, silica powder, silicone powder, metal oxide powder surface-treated with a surface treatment agent not containing metal, and the like. .
  • Examples of the drug include salts of L-ascorbic acid and its derivatives, glycyrrhizic acid and its derivatives such as dipotassium glycyrrhizinate and monoammonium glycyrrhizinate, glycyrrhetinic acid and its derivatives such as stearyl glycyrrhetinate, allantoin, tranexamic acid and its derivatives And salts of alkoxysalicylic acid and its derivatives, glutathione and its derivatives, allantoin, azulene and the like.
  • the sunscreen cosmetic of the present invention can be provided in the form of an oil-in-water emulsified cosmetic, a water-in-oil emulsified cosmetic, or an oily cosmetic.
  • an oil-in-water emulsified cosmetic emulsified cosmetic
  • a water-in-oil emulsified cosmetic emulsified cosmetic
  • an oily cosmetic emulsified cosmetic
  • dosage forms such as sunscreen milky lotion and sunscreen cream, which can be produced using a conventional method suitable for each dosage form.
  • the blending amount is expressed in mass% with respect to the system in which the component is blended.
  • SPF Sun Protection Factor
  • SPF synergistic with Comparative Example 4
  • Example 2 in which a part of the oil-based medium in Example 1 was replaced with water, and Examples 3 and 4 in which the blending amount and type of the ultraviolet scattering agent in Example 2 were changed within the scope of the present invention. (SPF), stability and usability, and satisfactory in appearance.
  • SPF stability and usability, and satisfactory in appearance.
  • the samples listed in Tables 1 and 2 did not feel irritation even when applied to the face except for Comparative Example 1.
  • SPF Sun Protection Factor
  • PA Protection Grade of UVA
  • tabletop xenon light resistance tester “Atlas Suntest XLS +” (Toyo Seiki Seisakusho) and a spectrophotometer “U-4100” (Hitachi Ltd.).
  • PA calculated using the apparatus was ++ or more was designated as A, and the case where PA was ⁇ PA ++ was designated as B.
  • the difference between the component (A) and the component (C) and the component (B) and the component (C) is 4% by mass or less, and the total amount of (C) ethylhexyl triazone and (E) the ultraviolet scattering agent is
  • the sunscreen cosmetics (Examples 7 and 8) of 8% by mass or more exhibited a very excellent protective effect in a wide wavelength range from UVA to UVB of 15 or more SPF and PA ++ or more in a well-balanced manner.
  • the SPF value is very high. Although it was a high value (27), it was PA ++. Further, in the cosmetic (Example 6) in which the total blending amount of (C) ethylhexyltriazone and (E) ultraviolet light scattering agent was less than 8% by mass, PA ++ or higher was achieved, but the SPF value was slightly decreased. .

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Abstract

L'objectif de la présente invention est de fournir un cosmétique d'écran solaire qui peut présenter un effet élevé de blocage des rayons ultraviolets même lorsque les quantités d'absorbeurs de rayons ultraviolets liquides méthoxycinnamate d'éthylhexyle et octocrylène sont réduites, et qui est stable, présente une excellente sensation en utilisation, et ne blanchit jamais de façon non naturelle lors de l'application. La présente invention concerne un cosmétique d'écran solaire comprenant (A) de 0,5 à 10,0 % en masse de t-butyl-méthoxydibenzoylméthane et/ou diéthylaminohydroxybenzoylhexylbenzoate, (B) 0,5 à 5,0 % en masse de bis-éthylhexyloxyphénolméthoxyphényltriazine, (C) 0,5 à 5,0 % en masse d'éthylhexyltriazone, (D) 5 à 50 % en masse d'une huile d'ester spécifique, et (E) 1,5 à 12 % en masse d'un agent de dispersion des rayons ultraviolets, dans lequel la quantité de formulation totale des composants (A), (B) et (C) est de 1,5 à 15 % en masse et la quantité de formulation de méthoxycinnamate d'éthylhexyle et d'octocrylène est de 3 % en masse ou moins.
PCT/JP2016/079012 2015-09-30 2016-09-30 Cosmétique d'écran solaire WO2017057677A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201680057322.7A CN108135817B (zh) 2015-09-30 2016-09-30 防晒化妆品
BR112018006175A BR112018006175A2 (pt) 2015-09-30 2016-09-30 cosmético protetor solar.
US15/762,452 US10328004B2 (en) 2015-09-30 2016-09-30 Sunscreen cosmetic
EP16851846.2A EP3357485A4 (fr) 2015-09-30 2016-09-30 Cosmétique d'écran solaire
KR1020187007899A KR102606444B1 (ko) 2015-09-30 2016-09-30 자외선 차단 화장료
HK18113674.6A HK1254690A1 (zh) 2015-09-30 2018-10-25 防曬化妝品

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2015194664 2015-09-30
JP2015-194664 2015-09-30
JP2016077552A JP6143914B2 (ja) 2015-09-30 2016-04-07 日焼け止め化粧料
JP2016-077552 2016-04-07

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WO2017057677A1 true WO2017057677A1 (fr) 2017-04-06

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BR112022008467A2 (pt) * 2019-11-05 2022-07-19 Dsm Ip Assets Bv Composição de protetor solar com baixa pegajosidade
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