WO2017057503A1 - Dialysate supply device - Google Patents

Dialysate supply device Download PDF

Info

Publication number
WO2017057503A1
WO2017057503A1 PCT/JP2016/078702 JP2016078702W WO2017057503A1 WO 2017057503 A1 WO2017057503 A1 WO 2017057503A1 JP 2016078702 W JP2016078702 W JP 2016078702W WO 2017057503 A1 WO2017057503 A1 WO 2017057503A1
Authority
WO
WIPO (PCT)
Prior art keywords
cleaning
connector
container
cleaning agent
pipe
Prior art date
Application number
PCT/JP2016/078702
Other languages
French (fr)
Japanese (ja)
Inventor
吉通 増田
藤原　真人
寛 二村
Original Assignee
日機装株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日機装株式会社 filed Critical 日機装株式会社
Publication of WO2017057503A1 publication Critical patent/WO2017057503A1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes

Definitions

  • the present invention relates to the structure of a dialysate supply device.
  • a dialysate supply device that mixes a plurality of drugs and a diluent (for example, water) to generate a dialysate and supplies the dialysate to the dialyzer has been used.
  • a dialysate supply device a predetermined amount of water is introduced into a bag containing two kinds of powdered medicines to dissolve the powder in the bag to generate a dialysate, and then the dialysate is put into a container.
  • a device that stores the dialysis fluid stored in the container and sucks it with a suction tube and supplies it to the dialysis circuit see, for example, Patent Document 1
  • a cartridge containing a medicine is mounted on the holder of the device. What is used is to inject metered water into a dialysate having a predetermined concentration (for example, see Patent Document 2).
  • Such a liquid flow path of the dialysate supply apparatus needs to be cleaned and disinfected with a cleaning / disinfectant such as a sodium hypochlorite solution or an acetic acid based solution after completion of dialysis.
  • a cleaning / disinfectant such as a sodium hypochlorite solution or an acetic acid based solution after completion of dialysis.
  • a sterilizing agent is put into a container, and the sterilizing agent is circulated through the entire system by a pump to clean the liquid flow path.
  • the cleaning / disinfecting agent in the chemical solution bottle is injected into the pipe from the chemical solution bottle using the chemical solution suction line and the chemical solution suction pump, thereby bypassing the drug cartridge.
  • a cleaning / disinfectant is circulated in the liquid flow path using piping to clean the liquid flow path.
  • an object of the present invention is to provide a dialysate supply apparatus that allows an operator to easily perform cleaning and disinfection of a liquid flow path with a simple configuration.
  • the dialysate supply device of the present disclosure is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer, and has a wetted part in contact with the dialysate
  • the cleaning / disinfecting agent for cleaning / disinfecting is provided with a cleaning agent charging mechanism for charging the diluent into the pipe through which the diluent flows, and the cleaning agent charging mechanism includes a cleaning agent container containing the cleaning / disinfecting agent, Between the pipe on one end side and the pipe on the other end side so that the pipe on one end side of the cleaning agent container and the pipe on the other end side of the cleaning agent container communicate with each other to form one liquid channel.
  • the cleaning agent container is sandwiched between the two.
  • annular upper connector in which a root side is connected to a pipe on one end side, and a tip end side is watertightly fitted to an outer periphery of an upper neck portion protruding to one end side of the cleaning agent container, and the upper connector
  • An annular lower connector that is coaxially disposed, has a root side connected to a pipe on the other end side, and a tip end side that is watertightly fitted to the outer periphery of the lower neck protruding to the other end side of the cleaning agent container, and the upper or lower connector
  • a connector moving mechanism that moves either or both along the longitudinal direction of the cleaning agent container, and each connector penetrates a sealing member that seals each end face of each neck near the annular center. It is good also as providing the nozzle to do.
  • a dialysate supply device is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer.
  • a medicine container that houses the medicine, a pipe on one end side of the medicine container, and a pipe on the other end side of the medicine container.
  • the drug container can be sandwiched between the pipe on one end side and the pipe on the other end side so as to form one liquid flow path, and in contact with the dialysate instead of the drug container.
  • a cleaning agent container containing a cleaning / disinfecting agent for cleaning / disinfecting the liquid part can be sandwiched between a pipe on one end side and a pipe on the other end side.
  • the drug charging mechanism includes a first fitting that is watertightly fitted to a first outer periphery of a first neck portion having a root side connected to a pipe on one end side and a tip side protruding to one end side of the drug container.
  • An annular first connector including a fitting portion, and a second fitting portion having a different shape from a first fitting portion that fits in a watertight manner on a second outer periphery of a second neck portion protruding toward one end of the cleaning agent container.
  • a third fitting that is arranged coaxially with the first connector, has a root side connected to a pipe on the other end side, and a tip end side that is watertightly fitted to the third outer periphery of the third neck portion protruding to the other end side of the drug container.
  • An annular second connector including a joint portion, and a fourth fitting portion having a different shape from a third fitting portion that fits in a watertight manner on the fourth outer periphery of the fourth neck portion protruding to the other end side of the cleaning agent container And either one or both of the first and second connectors are connected to the medicine container or the washing And a connector moving mechanism that moves along the longitudinal direction of the container, wherein the first connector and the second connector have nozzles that pass through seal members that seal the respective end faces of the neck portions in the vicinity of the annular center. It is good also as providing.
  • the inner diameter of the second fitting portion of the first connector is larger than that of the first fitting portion, and the tip of the first connector is larger than the first fitting portion.
  • the fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is closer to the distal end side of the second connector than the third fitting portion. It may be arranged.
  • a storage unit that holds at least one of the drug container and at least one cleaning agent container, and any one container from the storage unit is connected to the first connector and the second connector. It is good also as providing the feeding mechanism transferred between.
  • the storage unit may include a first hole that holds the drug container and a second hole that has a different shape from the first hole that holds the cleaning agent container. .
  • a filling state detection sensor that is attached to the medicine container or the cleaning agent container and detects a filling state of the medicine container or the cleaning agent container, and a signal from the filling state detection sensor
  • An input control unit, and the control unit may determine whether the drug container or the cleaning agent container is empty based on a signal from the filling state detection sensor.
  • the dialysate supply device may include a liquid backflow mechanism for backflowing the liquid from the other end side to the one end side of the cleaning agent container.
  • the nozzle is configured to fit the fourth neck portion of the cleaning agent container and the fourth portion when the fourth neck portion of the cleaning agent container is fitted into the fourth fitting portion in a watertight manner. It is good also as arrange
  • the present invention can provide a dialysate supply device that allows an operator to easily perform cleaning and disinfection of a liquid flow path with a simple configuration.
  • FIG. 4 is a view showing a flow of a cleaning / disinfecting liquid when a cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and a wetted part of the dialysate supply apparatus shown in FIG. 1 is cleaned.
  • FIG. 4 is a view showing a flow of a cleaning / disinfecting liquid when a cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and a wetted part of the dialysate supply apparatus shown in FIG. 1 is cleaned.
  • FIG. 4 is a view showing another flow of the cleaning / disinfecting liquid when the cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and the liquid contact portion of the dialysate supply device shown in FIG. 1 is cleaned.
  • FIG. 22 is a system diagram showing a flow of the cleaning / disinfecting liquid when a cleaning agent container is attached to the dialysate supplying apparatus shown in FIG. 21 and the cleaning / disinfecting liquid is made to flow backward to wash the liquid contact portion of the dialysate supplying apparatus. It is sectional drawing which shows the state of the flow of the cleaning / disinfecting liquid in the first and second connectors and the cleaning agent container when the cleaning / disinfecting liquid flows as shown in FIG.
  • FIG. 1 It is sectional drawing which shows the positional relationship of the fitting part of a 2nd connector, a nozzle, and the sealing member of a cleaning agent container at the time of attaching a cleaning agent container to the 2nd connector of the dialysate supply apparatus shown in FIG. It is sectional drawing which shows the positional relationship of the fitting part of a 2nd connector, the nozzle of another shape, and the sealing member of a cleaning agent container at the time of attaching a cleaning agent container to the 2nd connector of the dialysate supply apparatus shown in FIG. .
  • FIG. 4 is a system diagram showing the flow of the cleaning / disinfecting liquid when a cleaning agent container is attached to the configuration of the other dialysate supply device and the cleaning agent charging mechanism in the embodiment of the present disclosure to wash the liquid contact portion of the dialysate supply device. is there.
  • FIG. 30 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning agent container is attached to the dialysate supplying apparatus shown in FIG. 29 and the cleaning / disinfecting liquid is made to flow backward to wash the liquid contact portion of the dialysate supplying apparatus. It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication.
  • FIG. 31 shows the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is mixed with the RO water in the tank of the dialysing liquid supplying apparatus shown in FIG. It is a systematic diagram. It is a systematic diagram which shows the flow of the liquid at the time of discharging
  • FIG. 32 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is allowed to flow through the wetted part of the dialysate supply apparatus shown in FIG.
  • FIG. 36 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is discharged from the tank after the cleaning / disinfecting process shown in FIG. 35 is completed. It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication.
  • the dialysate supply device 100 is a batch-type dialysate supply device that generates and stores a predetermined concentration of dialysate in the tank 15 and supplies the stored dialysate to the dialyzer 96. As shown in FIG. 1, the dialysate supply device 100 generates high-purity RO water using a water supply pump 11 that supplies water from a water supply source such as tap water, a reverse osmosis membrane (RO membrane), and the like.
  • a water supply source such as tap water, a reverse osmosis membrane (RO membrane), and the like.
  • RO device 12 for performing the treatment a drug feeding mechanism 60 for feeding a drug for generating dialysate into RO water as a diluent, and a cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the dialysate
  • the cleaning agent charging mechanism 30 to be charged therein, the tank 15 for storing the generated dialysate, the liquid feed pump 70 for sending the dialysate in the tank 15 to the dialyzer 96, and the dialysate to be sent to the dialyzer 96 are heated.
  • a dialysate injection pump 97a dialysate IN pump
  • the blood of the patient flows from the artery through the blood inlet tube 93 to the blood inlet of the dialyzer 90 by the blood pump 97c, and returns to the patient's vein from the blood outlet tube 94 of the dialyzer 90.
  • the water supply pump 11 and the RO device 12 are connected by a water supply pipe 10, and the RO device 12, the drug charging mechanism 60, and the cleaning agent charging mechanism 30 are connected by an RO water pipe 13,
  • the mechanism 60, the cleaning agent charging mechanism 30 and the tank 15 are connected by a chemical charging pipe 14.
  • the tank 15 and the liquid feeding pump 70 are connected by a pump suction pipe 16.
  • the liquid feeding pump 70 and the heater 72 are heaters.
  • Connected by an inlet pipe 71, the heater 72 and the valve 77 are connected by a dialysate supply pipe 73, and the valve 77 and the coupler 81 are connected by a connecting pipe 76.
  • a dialysate discharge pipe 80 is connected to the coupler 82.
  • the dialysate supply pipe 73 and the RO water pipe 13 are connected by a recirculation pipe 78, and a valve 79 is disposed in the recirculation pipe 78.
  • the dialysate supply pipe 73 is provided with a temperature sensor 74 and a flow rate sensor 75 for detecting the temperature and flow rate of the dialysate supplied to the dialyzer 96.
  • the dialysate discharge pipe 80 is discharged from the dialyzer 96.
  • a flow sensor 83 for detecting the flow rate of the dialysate is attached. Further, in the dialysate supply apparatus 100 of the present embodiment, as indicated by a broken line in FIG.
  • another detergent charging mechanism 130 is disposed in the dialysate discharge pipe 80, and the dialysate discharge pipe 80 and The RO water pipe 13 is connected by another recirculation pipe 178, and a valve 179 is disposed in the recirculation pipe 178.
  • the drug injection mechanism 60 includes an inlet pipe 62 into which RO water as a diluent is introduced, an upper connector 66 a whose root is connected to the inlet pipe 62 and the tip fits into one end of the drug container 61, and the drug injection pipe 14.
  • An outlet pipe 63 connected to the bottom, a lower connector 66b having a root connected to the outlet pipe 63 and a tip fitted into the other end of the drug container 61, a valve 64 disposed on the inlet pipe 62 and the outlet pipe 63, respectively. 65.
  • the cleaning agent charging mechanism 30 includes an inlet pipe 32 into which RO water as a diluent is introduced, an upper connector 36a whose root is connected to the inlet pipe 32, and a tip is fitted into one end of the cleaning agent container 31;
  • the outlet pipe 33 connected to the medicine injection pipe 14, the lower connector 36 b whose root is connected to the outlet pipe 33 and the tip fits into the other end of the cleaning agent container 31, the inlet pipe 32, and the outlet pipe 33 are arranged. It is comprised by the valves 34 and 35 to be performed.
  • the dialysate is generated by mixing and diluting two agents, agent A and agent B.
  • agent A is an agent containing an electrolyte component (for example, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate), a pH adjuster (for example, acetic acid), a sugar (for example, glucose) and the like.
  • B agent is a chemical
  • the medicine charging mechanism 60 can attach a medicine container 61 filled with an amount of agent A or agent B necessary for generating dialysate once between the connectors 66a and 66b.
  • the A agent and the B agent may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent.
  • a sodium hypochlorite solution or an acetic acid solution is used as the cleaning / disinfecting agent.
  • the cleaning agent charging mechanism 30 can attach a cleaning agent container 31 filled with a cleaning agent or a disinfectant necessary for one cleaning / disinfection between the connectors 36a and 36b. These cleaning / disinfecting agents may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent.
  • the cleaning agent container 31 is a cylinder or a square tube, and includes a main body 31e for storing the cleaning / disinfecting agent, a cylindrical upper neck portion 31a protruding upward, and a cylinder protruding downward. And a lower neck portion 31b of the shape.
  • the opening at the upper end of the upper neck portion 31a and the opening at the lower end of the lower neck portion 31b are sealed by sheet-like sealing members 31c and 31d, respectively.
  • the size of the main body 31e can be appropriately changed according to the type of cleaning / disinfecting agent and the amount required for one cleaning / disinfecting.
  • the drug container 61 has the same shape as the cleaning agent container 31, but the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the upper and lower neck portions 31a and 31b are as shown in FIG. It is different from the outer diameter.
  • the size of the main body 61e is changed depending on the type of medicine and the amount required for one generation of dialysate.
  • the water supply pump 11, the liquid feed pump 70, the cleaning agent charging mechanism 30, the drug charging mechanism 60, the heater 72, the valves 77, 79, and 179 are connected to the control unit 95 and are driven or opened / closed according to commands from the control unit 95. . Further, detection signals from the temperature sensor 74 and the flow rate sensors 75 and 83 are input to the control unit 95.
  • the control unit 95 is a computer that includes a CPU that performs information processing and a storage unit that stores control programs and data.
  • the cleaning agent charging mechanism 30 includes an upper connector 36a, a lower connector 36b disposed coaxially with the upper connector 36a, a connector moving mechanism 560 that drives the connectors 36a and 36b in the vertical direction, An inlet pipe 32, an outlet pipe 33, a valve 34 disposed in the inlet pipe 32, and a valve 35 disposed in the outlet pipe 33 are included.
  • the upper connector 36 a includes an upper base 500 and an upper fitting block 550 that is fixed to the lower surface of the upper base 500 with bolts 558.
  • the lower connector 36b includes a lower base 600 and a lower fitting block 650 that is fixed to the upper surface of the lower base 600 with bolts 658.
  • the upper base 500 of the upper connector 36a includes a metal flat plate 501 and an upper nozzle 503 protruding downward from the center of the lower surface of the flat plate 501.
  • the flat plate 501 is connected to the connector moving mechanism 560 by an arm 506.
  • a flow hole 502 for introducing RO water that is a diluent is provided inside the flat plate 501.
  • the circulation hole 502 extends to the side surface of the flat plate 501 and opens, and the inlet pipe 32 is connected to the opening.
  • the upper nozzle 503 has a rod shape with a sharp tip, and a flow hole 504 extending in the axial direction is provided in the center portion so as to communicate with the flow hole 502 of the flat plate 501.
  • a flow hole 505 that communicates with the flow hole 504 and extends in the radial direction and opens to the outer surface of the upper nozzle 503 is provided at the tip portion of the upper nozzle 503.
  • the upper fitting block 550 of the upper connector 36a includes a flange 551 fixed to the flat plate 501 of the upper base 500 with a bolt 558, and an upper main body 550a extending downward from the center of the flange 551.
  • the upper main body 550a has an annular shape and is provided with a circular two-stage hole in the center.
  • a nozzle mounting hole 553 having the same diameter as the outer diameter of the upper nozzle 503 is provided on the upper base 500 side of the upper main body 550a, and an annular upper neck portion of the cleaning agent container 31 as shown in FIG.
  • An upper fitting hole 555 for fitting 31a is provided.
  • the inner diameter of the upper fitting hole 555 is substantially the same as the outer diameter of the upper neck portion 31a.
  • a packing 554 is attached to the inner surface of the nozzle mounting hole 553 for watertight sealing with the outer surface of the upper nozzle 503.
  • a packing 556 is also provided on the inner surface of the upper fitting hole 555 for watertight sealing between the cleaning container 31 and the upper neck portion 31a.
  • the upper fitting hole 555 and the packing 556 constitute an upper fitting portion.
  • a packing 552 is also provided on a surface connected to the flat plate 501 of the upper base 500 of the upper fitting block 550.
  • the lower base 600 of the lower connector 36b includes a metal flat plate 601 and a lower nozzle 603 protruding upward from the center of the upper surface of the flat plate 601.
  • the flat plate 601 is connected to the connector moving mechanism 560 by an arm 606.
  • the lower nozzle 603 is shaped like a cylinder cut diagonally, has a sharp tip, a flow hole 605 having a large inner diameter is provided on the tip side, and communicates with the flow hole 605 on the lower base 600 side.
  • a flow hole 604 extending in the axial direction is provided.
  • a flow hole 602 that communicates with the flow hole 604 of the lower nozzle 603 is provided inside the flat plate 601.
  • the circulation hole 602 extends to the side surface of the flat plate 601 and is opened, and the outlet pipe 33 is connected to the opening. As shown in FIG. 4, the cleaning / disinfecting agent filled in the cleaning agent container 31 attached between the upper connector 36a and the lower connector 36b, and the RO introduced into the cleaning agent container 31 from the upper connector 36a. Water flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 and the flow holes 602 of the lower base 600.
  • the lower fitting block 650 of the lower connector 36b has substantially the same configuration as the upper fitting block 550, and includes a flange 651 and a lower main body 650a extending upward from the center of the flange 651.
  • the lower main body 650a has an annular shape and is provided with a circular two-stage hole in the center.
  • a nozzle mounting hole 653 having a diameter the same as the outer diameter of the lower nozzle 603 is provided on the lower base 600 side of the lower main body 650a, and an annular lower neck portion of the cleaning agent container 31 as shown in FIG.
  • a lower fitting hole 655 for fitting 31b is provided.
  • the inner diameter of the lower fitting hole 655 is substantially the same as the outer diameter of the lower neck portion 31b.
  • a packing 654 is attached to the inner surface of the nozzle mounting hole 653 for watertight sealing with the outer surface of the lower nozzle 603.
  • a packing 656 is provided on the inner surface of the lower fitting hole 655 to seal the space between the lower neck portion 31b of the cleaning agent container 31 in a watertight manner.
  • Lower fitting hole 655 and packing 656 constitute a lower fitting portion.
  • a packing 652 is also provided on the surface of the lower base 600 that is connected to the flat plate 601 of the lower fitting block 650.
  • the center of the two-step hole of the upper fitting block 550 of the upper connector 36a that is, the center of the nozzle mounting hole 553 and the upper fitting hole 555, and the two of the lower fitting block 650 of the lower connector 36b.
  • the center of the step hole that is, the center of the nozzle mounting hole 653 and the lower fitting hole 655 is disposed on the same center line 580. Therefore, the upper and lower fitting holes 555 and 655 are arranged coaxially.
  • the centers of the upper nozzle 503 and the lower nozzle 603 are also arranged on the center line 580 and are coaxially arranged.
  • the connector moving mechanism 560 is connected to the control unit 95, and moves either one or both of the upper connector 36a and the lower connector 36b in the vertical direction according to a command from the control unit 95 or an operation of the operator.
  • the medicine charging mechanism 60 has the same structure as the cleaning agent charging mechanism 30 described above, and includes an upper connector 66a, a lower connector 66b arranged coaxially with the upper connector 66a, and connector movement for driving each connector in the vertical direction. It includes a mechanism 560, an inlet pipe 62, an outlet pipe 63, a valve 64 disposed in the inlet pipe 62, and a valve 65 disposed in the outlet pipe 63.
  • the inner diameters of the upper fitting hole 555 of the upper connector 66a and the lower fitting hole 655 of the lower connector 66b are substantially the same as the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the drug container 61 shown in FIG. .
  • the cleaning agent container 31 is attached to the cleaning agent charging mechanism 30 with the valves 34, 35, 64, and 65 shown in FIG.
  • the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98.
  • the coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.
  • the upper connector 36a is moved upward and the lower connector 36b is moved downward by the connector moving mechanism 560.
  • the centers of the upper neck portion 31 a and the lower neck portion 31 b of the cleaning agent container 31 are positioned at the position of the center line 580. In the state where the cleaning agent container 31 is held, the lower connector 36b is moved upward and the upper connector 36a is moved downward.
  • the lower connector 36b breaks the seal member 31d at the sharp tip of the lower nozzle 603 and enters the cleaning agent container 31, and the lower fitting hole 655 fits into the outer periphery of the lower neck portion 31b. And the packing 656 of the lower fitting hole 655 adheres to the outer periphery of the lower neck part 31b.
  • the upper connector 36a breaks the seal member 31c at the sharp tip of the upper nozzle 503 and enters the cleaning agent container 31, and the upper fitting hole 555 fits into the outer periphery of the upper neck portion 31a.
  • the packing 556 of the upper fitting hole 555 adheres to the outer periphery of the upper neck part 31a.
  • the cleaning / disinfecting agent filled in the cleaning agent container 31 When the cleaning / disinfecting agent filled in the cleaning agent container 31 is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 31 to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 through the flow holes 602 of the flat plate 601. And it flows in into the tank 15 through the chemical
  • the water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
  • the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R12 indicated by a one-dot chain line in FIG. [Tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate supply pipe 73 ⁇ recirculation pipe 78 (valve 79) ⁇ RO water pipe 13 ⁇ cleaner injection mechanism 30 ⁇ chemical supply Tube 14 ⁇ tank 15] is circulated, and the wetted parts of each device and pipe are cleaned and disinfected. When the cleaning and disinfection of the flow path R12 shown in FIG. 5 is performed for a predetermined time, the cleaning and disinfection of the flow path R12 is finished.
  • the valve 79 is closed and the valve 77 is opened as shown in FIG.
  • the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate as shown in the flow path R13 of FIG. Supply pipe 73 ⁇ valve 77 ⁇ connection pipe 76 ⁇ coupler 81 ⁇ connection coupler 98 ⁇ coupler 82 ⁇ dialysate discharge pipe 80], and is discharged from the drain to the outside of the system.
  • the primary cleaning of the liquid contact portion of the dialysate supply device 100 is finished.
  • the cleaning agent container 131 is attached to the other cleaning agent charging mechanism 130 in the same procedure as that for attaching the cleaning agent container 31 to the cleaning agent charging mechanism 30, and the water supply pump 11 removes the RO device 12 from the RO device 12.
  • a predetermined amount of RO water is stored in the tank 15, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, and the RO water is introduced from the tank 15 into the cleaning agent container 131 by the liquid feeding pump 70, and the cleaning / disinfecting solution is allowed to flow.
  • the RO water is introduced into the system by the water supply pump 11 and circulated through the flow path R12 shown in FIG. 5 or the flow path R14 shown in FIG. Flushing for discharging the RO water accumulated in the tank 15 from the drain to the outside of the system by the path R13 is performed, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 100 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
  • the upper container 36a and the lower connector 36b of the cleaning agent charging mechanism 30 are provided with the cleaning agent container 31 filled and sealed by the operator with a predetermined amount of cleaning / disinfecting agent.
  • the liquid contact part of the dialysate supply device 100 can be cleaned and disinfected by simply setting the gap between the liquid channel and the operator so that the liquid flow path can be easily cleaned and disinfected without touching the cleaning / disinfectant. It can be carried out.
  • the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
  • the drug container 61 is attached to the drug input mechanism 60 in the same manner as the cleaning agent container 31 is attached to the cleaning agent input mechanism 30.
  • RO water is introduced into the drug container 61 to dissolve the drug to obtain a high-concentration dialysate, and flows into the tank 15 from the drug input tube 14. Then, RO water is caused to flow into the tank 15 until a predetermined concentration is reached, and a dialysate having a predetermined concentration is generated and stored in the tank 15. Then, the dialysate having a predetermined concentration stored in the tank 15 is supplied to the dialyzer 96 by the liquid feed pump 70.
  • a dialysate supply apparatus 200 according to another embodiment will be described with reference to FIGS. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted.
  • the dialysate supply apparatus 200 shown in FIG. 7 generates and stores a predetermined concentration of dialysate in the tank 15 as described with reference to FIGS. 1 to 6, and supplies the stored dialysate to the dialyzer 96.
  • high concentration A agent and B agent are continuously added little by little into the RO water pipe 13 to generate a predetermined concentration of dialysate and supply it to the dialyzer 96. is there.
  • the cleaning agent charging mechanism 30 is disposed so as to bypass the RO water pipe 13, and a valve 37 is disposed in the RO water pipe 13 parallel to the cleaning agent charging mechanism 30.
  • the dialysate supply apparatus 200 includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13.
  • Another recirculation pipe 178 and a valve 179 are provided.
  • the drug charging mechanism 55 includes a B agent charging mechanism 40 and an A agent charging mechanism 50.
  • the B agent charging mechanism 40 connects the upper and lower sides of the B agent container 41 filled with the B agent (powder agent) to the connectors 49a and 49b, and is disposed in the inlet pipe 42, the outlet pipe 43 and the inlet pipe 42.
  • a B agent injection pump 44, a valve 46, a bypass pipe 47 and a valve 48 disposed in the valve 45 and the outlet pipe 43 are included.
  • the structures of the connectors 49a and 49b are the same as those described with reference to FIGS. 3 and 4, but the flow paths provided in the connectors 49a and 49b of the B agent container 41 (shown in FIGS. 3 and 4).
  • a flow path closing mechanism capable of closing the flow holes 502 or 504, 602 or 604) is attached.
  • the valves 45 and 46 are opened, and a predetermined amount of RO water is introduced into the B agent container 41.
  • a B agent solution having a saturated concentration is generated in the RO water pipe 13 by a B agent injection pump 44 little by little.
  • the agent A charging mechanism 50 includes an agent A tank 51 containing a high-concentration solution of agent A, an agent A injection pump 53, an injection pipe 52 and a valve 54, and injects agent A.
  • the valve 54 Opens the valve 54, sucks up the solution of the agent A from the agent A tank 51 by the agent A injection pump 53 and injects it into the RO water pipe 13 little by little.
  • the injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by a conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44, 53.
  • the control unit 95 adjusts based on this.
  • the solutions of agent A and agent B injected into the RO water pipe 13 are mixed with RO water in a mixing chamber (not shown) and supplied to the dialyzer 96 as a dialysate having a predetermined concentration.
  • the cleaning agent container 31 is attached between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30 in the same procedure as described with reference to FIGS. Further, the flow path closing mechanism of the connectors 49a and 49b of the B agent charging mechanism 40 closes the flow paths of the connectors 49a and 49b, and the valve 48 is opened so that the cleaning / disinfecting liquid passes through the bypass pipe 47. Then, the valve 37 of the RO water pipe 13, the valve 54 of the agent A charging mechanism 50, the valve 77 of the dialysate supply pipe 73 are closed, and the valve 79 of the recirculation pipe 78 and the valves 34 and 35 of the cleaning agent charging mechanism 30 are opened.
  • RO water is introduced from the RO device 12 into the cleaning agent container 31 through the inlet pipe 32, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 33.
  • the recirculation pipe 78, the cleaning agent charging mechanism 30, the bypass pipe 47 of the B agent charging mechanism 40, the liquid feeding pump 70, and the cleaning / disinfecting liquid are circulated from the liquid feeding pump 70. First cleaning is performed.
  • the cleaning / disinfecting liquid is discharged from the drain to the outside while injecting RO water into the system through the flow path R23 shown in FIG. Then, the RO water is introduced into another cleaning agent charging mechanism 130 to generate a cleaning / disinfecting solution, and the RO water pipe 13, the cleaning agent charging mechanism 30, B, and the like from the dialysate discharge pipe 80 by the flow path R24 shown in FIG. It is circulated through the agent charging mechanism 40 and the liquid feed pump 70 to perform secondary cleaning of the liquid contact portion. After the secondary cleaning, RO water is circulated through the flow path R22 shown in FIG. 8 or the flow path R24 shown in FIG. 9, and then the dialysis / cleaning solution is discharged from the drain to the outside as shown in the flow path R23 shown in FIG. The wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
  • the dialysate supply apparatus 200 of the present embodiment is similar to the dialysate supply apparatus 100 described above, and the detergent container 31 is filled and sealed by the operator with a predetermined amount of cleaning / disinfectant.
  • the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
  • a dialysate supply apparatus 300 according to another embodiment will be described with reference to FIGS. 10 to 17. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted. As shown in FIG. 10, the dialysate supply apparatus 300 of the present embodiment generates and stores a predetermined concentration of dialysate in the tank 15, as described with reference to FIGS. 1 to 6.
  • the cleaning agent containers 21 ⁇ / b> C and 21 ⁇ / b> D may be attached to supply the cleaning / disinfecting liquid to the tank 15.
  • the dialysate supply device 300 of the present embodiment as in the dialysate supply devices 100 and 200 described above, as another option, as shown by a broken line in FIG.
  • An agent charging mechanism 130 is arranged, the dialysate discharge pipe 80 and the RO water pipe 13 are connected by another recirculation pipe 178, and a valve 179 is arranged in the recirculation pipe 178.
  • the medicine injection mechanism 20 includes a storage unit 720 that holds the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D, a motor 708 that rotates the storage unit 720, and an upper side.
  • the storage unit 720 is obtained by integrally fixing an upper disc 700 having a plurality of holes 701 to 704 and a lower disc 710 as shown in FIGS. 12A and 12B with a connection shaft 707.
  • the upper disc 700 has a plurality of large round holes 701 for receiving the main body 21Ae of the agent A container 21A shown in FIG. 11 and a plurality of small holes for receiving the main bodies 21Be of the agent B container 21B shown in FIG.
  • a round hole 702 a large square hole 703 for receiving the main body 21Ce of the cleaning agent container 21C shown in FIG. 11, and a small square hole 704 for receiving the main body 21De of the cleaning agent container 21D shown in FIG.
  • the internal dimensions of the holes 701 to 704 are substantially the same as the external dimensions of the main bodies 21Ae to 21De of the containers 21A to 21D.
  • the lower disk 710 has lower necks 21Ab to 21Db of the containers 21A to 21D shown in FIG. 11 at positions corresponding to the round holes 701 and 702 and the square holes 703 and 704 of the upper disk 700.
  • the diameter of the round hole 711 may be larger than the outer diameter of the lower neck portions 21Ab to 21Db and smaller than the outer dimensions of the main bodies 21Ae to 21De.
  • the center of the upper disc 700 and the lower disc 710 is connected by a boss 706, and a shaft 705 is attached to the center of the boss 706.
  • the shaft 705 is connected to the shaft 705 of the motor 708, and the storage unit 720 is configured to rotate by the motor 708.
  • the first connector 26a and the second connector 26b are connected to the connector moving mechanism 560 by arms 506 and 606, respectively.
  • the first connector 26a and the second connector 26b are arranged so that their centers are on the same center line 580, and are opened in the upper disk 700 of the storage unit 720.
  • the holes 701 to 704 and the plurality of round holes 711 formed in the lower disk 710 are arranged so that their centers are on the circumference intersecting the center line 580 of the first connector 26a and the second connector 26b. Has been.
  • the center axes of the predetermined containers 21A to 21D can be aligned with the center lines 580 of the first connector 26a and the second connector 26b.
  • the storage unit 720 is connected to the control unit 95 and rotates according to a command from the control unit 95.
  • the bases 500 and 600 of the first connector 26a and the second connector 26b have the same structure as the bases 500 and 600 of the upper connector 36a and the lower connector 36b described above with reference to FIG.
  • the first fitting block 510 and the lower second fitting block 610 are different from the upper fitting block 550 and the lower fitting block 650 described with reference to FIG. 3 in the first main body 510a and the second main body 610a.
  • An annular three-stage hole is provided.
  • the first main body 510a has an annular shape and is provided with a circular three-stage hole in the center.
  • a nozzle mounting hole 513 is provided on the upper base 500 side of the first main body 510a, and a second fitting into which the outer periphery of the annular upper neck portion 21Ca of the cleaning agent container 21C is fitted, as shown in FIG.
  • a joint hole 515 is provided.
  • the inner diameter of the second fitting hole 517 is larger than the inner diameter of the first fitting hole 515.
  • the inner diameter of the first fitting hole 515 and the inner diameter of the second fitting hole 517 are substantially the same as the outer diameter of the upper neck portion 21Ba of the B agent container 21B and the upper neck portion 21Ca of the cleaning agent container 21C, respectively.
  • a packing 514 for watertightly sealing the outer surface of the upper nozzle 503 is attached to the inner surface of the nozzle mounting hole 513, and the upper neck portion 21Ba of the B agent container 21B is attached to the inner surface of the first fitting hole 515.
  • a packing 516 is provided for watertight sealing between the outer peripheral surface and the inner surface of the second fitting hole 517 for watertight sealing between the outer peripheral surface of the upper neck portion 21Ca of the cleaning agent container 21C.
  • a packing 518 is attached.
  • the first fitting hole 515 and the packing 516 constitute a first fitting portion
  • the second fitting hole 517 and the packing 518 constitute a second fitting portion
  • the outer periphery of the cleaning agent container 21C with the annular upper neck portion 21Ca constitutes the second neck portion and the second outer periphery, respectively
  • the upper neck portion 21Ba of the B agent container 21B and the outer periphery thereof are respectively connected with the first neck portion and the second outer periphery. 1 circumference is comprised.
  • the second main body 610a has an annular shape and a circular three-stage hole at the center, similarly to the first main body 510a.
  • a nozzle mounting hole 613 is provided on the lower base 600 side of the second main body 610a, and a fourth fitting into which the outer periphery of the annular lower neck portion 21Cb of the cleaning agent container 21C is fitted, as shown in FIG.
  • a joint hole 617 is provided, and a third fitting in which the outer periphery of the lower neck portion 21Bb of the B agent container 21B is fitted between the nozzle mounting hole 613 and the fourth fitting hole 617 as shown in FIG.
  • a joint hole 615 is provided.
  • the inner diameter of the fourth fitting hole 617 is larger than the inner diameter of the third fitting hole 615.
  • the inner diameter of the third fitting hole 615 and the inner diameter of the fourth fitting hole 617 are approximately the same diameter as the outer diameter of the lower neck portion 21Bb of the B agent container 21B and the lower neck portion 21Cb of the cleaning agent container 21C, respectively.
  • a packing 614 for watertight sealing with the outer peripheral surface of the lower nozzle 603 is attached to the inner surface of the nozzle attachment hole 613, and the lower neck portion 21Bb of the B agent container 21B is attached to the inner surface of the third fitting hole 615.
  • a packing 616 for watertight sealing between the outer peripheral surface of the cleaning container 21C and the outer surface of the lower neck portion 21Cb of the cleaning agent container 21C is sealed on the inner surface of the fourth fitting hole 617.
  • a packing 618 is attached.
  • the third fitting hole 615 and the packing 616 constitute a third fitting portion
  • the fourth fitting hole 617 and the packing 618 constitute a fourth fitting portion
  • the annular lower neck portion 21Cb of the cleaning agent container 21C and the outer periphery thereof constitute a fourth neck portion and a fourth outer periphery, respectively
  • the lower neck portion 21Bb of the B agent container 21B and the outer periphery thereof are respectively connected to the third neck portion.
  • a third outer periphery is formed.
  • the B agent container 21B and the cleaning agent container 21C have been described as examples.
  • the outer diameters of the upper neck portion 21Aa, the lower neck portion 21Ab, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are as follows.
  • the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B are the same as the outer diameters of the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C.
  • the upper neck portion 21Aa and the lower neck portion 21Ab of the A agent container 21A are respectively the same.
  • the first and third fitting holes 515 and 615 are fitted, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are fitted into the second and fourth fitting holes 517 and 617, respectively.
  • the agent A container 21A, the agent B container 21B, and the detergent containers 21C and 21D are containers 21 that can be held in the storage unit 720.
  • the A agent containers 21A, B are inserted into the holes 701 to 704 of the storage unit 720.
  • the agent container 21B, the detergent container 21C, and the detergent container 21D are set in advance.
  • the first connector 26 a is moved upward and the second connector 26 b is moved downward by the connector moving mechanism 560, and the tip of the upper nozzle 503 and the lower nozzle 603 are moved. Is made longer than the overall length of the B agent container 21B in the vertical direction.
  • the storage unit 720 is rotated by the motor 708 shown in FIG.
  • the center of the B agent container 21B is set at the same position as the center line 580 of the first and second connectors 26a and 26b as shown in FIG.
  • the moving mechanism 560 moves the second connector 26b upward and the first connector 26a downward.
  • the second connector 26b breaks the seal member 21Bd at the sharp tip of the lower nozzle 603 and enters the B agent container 21B, and the third fitting hole 615 fits into the outer periphery of the lower neck portion 21Bb.
  • the first connector 26a breaks the seal member 21Bc at the sharp tip of the upper nozzle 503 and enters the B agent container 21B, and the first fitting hole 515 fits into the outer periphery of the upper neck portion 21Ba. And the packing 516 of the 1st fitting hole 515 closely_contact
  • the B agent container 21B is sandwiched between the first connector 26a and the second connector 26b, and the B agent container 21B, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.
  • the valves 24 and 25 are opened, and RO water is introduced into the B agent container 21B to dissolve the B agent into a high-concentration solution and flow into the tank 15 from the drug introduction tube 14.
  • the first connector 26a and the second connector 26b are moved so as to open in the vertical direction, and the distance between the tip of the upper nozzle 503 and the tip of the lower nozzle 603 is larger than the total length in the vertical direction of the B agent container 21B.
  • the storage unit 720 is rotated so that the center of the agent A container 21A is located at the same position as the center line 580 of the first and second connectors 26a and 26b, and the connector moving mechanism 560 is operated to operate the agent A.
  • the container 21A is attached between the first and second connectors 26a and 26b. And RO water is introduce
  • FIGS. 10 a method for cleaning and disinfecting the liquid contact portion of the dialysate supply apparatus 200 by attaching the cleaning agent container 21C to the medicine charging mechanism 20 will be described with reference to FIGS.
  • the valves 24 and 25 shown in FIG. 10 are closed, and the cleaning agent container 21 ⁇ / b> C is attached to the medicine charging mechanism 20.
  • the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98.
  • the coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.
  • the process of attaching the cleaning agent container 21C to the medicine injection mechanism 20 is the same as the process of attaching the B agent container 21B described above to the medicine injection mechanism 20, but as shown in FIG. 15, the fourth of the second connector 26b.
  • the fitting hole 617 is fitted into the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C, and the packing 618 of the fourth fitting hole 617 is in close contact with the outer periphery of the lower neck portion 21Cb.
  • the second fitting hole 517 of the first connector 26a is fitted into the outer periphery of the upper neck portion 21Ca.
  • the cleaning agent container 21C is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.
  • the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 that are in contact with the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb when the B agent container 21B is attached to the medicine injection mechanism 20.
  • the B agent or the A agent remaining on the contact surface inside each fitting hole 515, 615 can be washed.
  • the cleaning / disinfecting agent filled in the cleaning agent container 21C When the cleaning / disinfecting agent filled in the cleaning agent container 21C is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 21C to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 23 through the flow holes 605 and 604 of the lower nozzle 603, through the flow holes 602 of the flat plate 601. Then, as shown in a flow path R31 of FIG.
  • the water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
  • the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R32 indicated by a one-dot chain line in FIG. [Tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate supply pipe 73 ⁇ recirculation pipe 78 (valve 79) ⁇ RO water pipe 13 ⁇ drug injection mechanism 20 ⁇ drug injection pipe 14 ⁇ Tank 15] to circulate and clean and disinfect the wetted parts of each device and piping. At that time, as shown in FIG.
  • the cleaning / disinfecting liquid flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603 to clean the inner surface of the third fitting hole 615. ⁇ Disinfect.
  • the cleaning / disinfection of the flow path R32 shown in FIG. 16 is performed for a predetermined time, the cleaning / disinfection of the flow path R32 is terminated.
  • the valve 79 is closed and the valve 77 is opened as shown in FIG.
  • the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate.
  • the primary cleaning of the liquid contact portion of the dialysate supply device 300 is finished.
  • the cleaning agent container 131 is attached to another cleaning agent charging mechanism 130, and the RO device 12 is transferred from the RO device 12 to the tank 15 by the water supply pump 11.
  • a predetermined amount of RO water is stored, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, the RO pump 70 introduces the RO water from the tank 15 into the cleaning agent container 131, and the cleaning / disinfecting solution flows into the flow path R34.
  • the RO water is caused to flow into the system by the water supply pump 11 while circulating the flow path R32 shown in FIG. 16 or the flow path R34 shown in FIG. Flushing is performed to discharge the RO water accumulated in the tank 15 from the drain to the outside of the system by the flow path R33 shown in FIG. 17, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 300 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
  • the operator puts the cleaning agent container 21C or 21D filled and sealed with a predetermined amount of the cleaning / disinfecting agent into the hole 703 of the storage unit 720 of the medicine charging mechanism 20. 704, the fluid contact part of the dialysate supply device 300 can be cleaned and disinfected, so that the operator can easily clean and disinfect the liquid flow path without touching the cleaning / disinfectant. It can be carried out. Further, the dialysate supply device 300 of the present embodiment can supply the A agent, the B agent, and two types of cleaning / disinfecting agents to the pipe or the tank 15 by the single medicine input mechanism 20, and thus has a simple configuration. It can be.
  • the dialysate supply device 300 includes the main bodies 21Ae, 21Be, 21Ce, and 21De of the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D that are held in the storage unit 720 by the control unit 95.
  • the upper disc 700 of the storage unit 720 is provided with holes 701 to 704 according to the shape of each main body, so that the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D are provided. You can avoid mistakes.
  • an IC chip or the like is attached to each container 21A to 21D, and the control unit 95 rotates the storage unit 720 to select the A agent container 21A, the B agent container 21B, or the cleaning agent containers 21C and 21D.
  • the center line 580 between the first connector 26a and the second connector 26b is such that the container 21 filled with the correct medicine or cleaning agent is determined by determining whether the container 21 is filled with the medicine from the information on the IC chip. It is possible to prevent an erroneous injection of the medicine by controlling it so as to be positioned above.
  • the dialysate supply apparatus 300 of the present embodiment connects the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C with the first and second connectors 26a and 26b, respectively.
  • the first and third fitting holes 515 and 615 in which the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B described above with reference to FIG. There is a space between the inner surface and the outer surfaces of the upper nozzle 503 and the lower nozzle 603.
  • the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 that are in contact with the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb when the B agent container 21B is attached to the medicine injection mechanism 20.
  • the B agent or the A agent remaining on the contact surface inside each fitting hole 515, 615 can be washed.
  • a dialysate supply apparatus 400 according to another embodiment will be described with reference to FIGS. Parts similar to those of the embodiment described with reference to FIGS. 1 to 17 are denoted by the same reference numerals and description thereof is omitted.
  • the dialysate supply device 400 shown in FIG. 18 is continuously charged with a high concentration of agent A and agent B into the RO water pipe 13 little by little, like the dialysate supply device 200 described above with reference to FIG. Thus, a dialysate having a predetermined concentration is generated and supplied to the dialyzer 96.
  • the configuration of the medicine injection mechanism 60 of the present embodiment is the same as the first and second connectors 26a and 26b and the connector moving mechanism 560 described above with reference to FIGS. 126a, 126b, and a connector moving mechanism 560, which are configured so that the B agent container 21B and the cleaning agent containers 21C, 21D can be attached. Note that the storage unit 720 described with reference to FIGS. 11, 12A, and 12B is not provided.
  • the dialysate supply device 400 of this embodiment includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13.
  • Another recirculation pipe 178 and a valve 179 are provided.
  • the dialysate When the dialysate is supplied to the dialyzer 96 by the dialysate supply device 400 shown in FIG. 18, as shown in FIG. 14, the first fitting of the first connector 126a is performed on the outer periphery of the upper neck portion 21Ba of the B agent container 21B.
  • the B agent container 21B is fitted into the first and second connectors so that the hole 515 and the packing 516 are fitted, and the third fitting hole 615 and the packing 616 of the second connector 126b are fitted into the outer periphery of the lower neck portion 21Bb of the B agent container 21B.
  • the B agent container 21B, the inlet pipe 122, and the outlet pipe 123 communicate with each other so as to form one liquid flow path.
  • the valves 124 and 125 are opened, the RO water is introduced into the B agent container 21B, the B agent is dissolved to produce a high concentration solution, and the B agent injection pump 44 has a concentration in the RO water pipe 13.
  • B solution of B is injected little by little.
  • the A agent is sucked up from the A agent tank 51 by the A agent injection pump 53 and injected into the RO water pipe 13 little by little.
  • the injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by a conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44, 53.
  • the control unit 95 adjusts based on this.
  • the solutions of the B agent and the A agent injected into the RO water pipe 13 are mixed in a mixing chamber (not shown) to become a predetermined concentration dialysate and supplied to the dialyzer 96.
  • valves 124 and 125 are closed, the B agent container 21B attached between the first and second connectors 126a and 126b of the medicine injection mechanism 120 is removed, and the cleaning agent container 21C is the same as described above. It attaches between the 1st, 2nd connectors 126a and 126b by a method.
  • the second fitting hole 517 and the packing 518 of the first connector 126a are fitted into the outer periphery of the upper neck portion 21Ca of the cleaning agent container 21C, and the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C.
  • the cleaning agent container 21C is sandwiched between the first and second connectors 126a and 126b so that the fourth fitting hole 617 and the packing 618 of the second connector 126b are fitted into the first connector 126b, the cleaning agent container 21C, the inlet pipe 122, and the outlet pipe. 123 communicates with each other to form one liquid flow path.
  • valve 54 of the agent A charging mechanism 50 and the valve 77 of the dialysate supply pipe 73 are closed, and the valves 124 and 125 and the valve 79 of the recirculation pipe 78 are opened.
  • RO water is introduced from the RO device 12 into the cleaning agent container 21 ⁇ / b> C through the inlet pipe 122, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 123.
  • the primary cleaning is performed by circulating the cleaning / disinfecting liquid through the recirculation pipe 78, the medicine feeding mechanism 120, the liquid feeding pump 70 and the cleaning / disinfecting liquid as shown in the flow path R42 shown in FIG.
  • the cleaning / disinfecting liquid is discharged out of the system from the drain while injecting RO water into the system through the flow path R43 shown in FIG. Further, the RO water is introduced into another cleaning agent charging mechanism 130 to generate cleaning / disinfecting liquid, and the recirculation pipe 178, the RO water pipe 13, and the chemicals are input from the dialysate discharge pipe 80 through the flow path R44 shown in FIG.
  • the mechanism 60 and the liquid feed pump 70 By circulating through the mechanism 60 and the liquid feed pump 70, the wetted part is subjected to secondary cleaning. After the secondary cleaning, RO water is circulated through the flow path R42 shown in FIG. 19 or the flow path R44 shown in FIG.
  • the dialysis / cleaning liquid is discharged from the drain to the outside as shown in the flow path R43 shown in FIG.
  • the wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
  • the operator puts the cleaning agent container 21C filled and sealed with a predetermined amount of the cleaning / disinfectant into the medicine charging mechanism 120. Since the liquid contact part can be cleaned and disinfected by simply setting it between the first connector 126a and the second connector 126b, the operator can easily clean the liquid flow path without touching the cleaning / disinfectant. ⁇ Can disinfect. Further, the first and second connectors 126a and 126b of the drug injection mechanism 120 of the dialysate supply apparatus 400 of the present embodiment can be attached with either a drug container or a cleaning agent container, and supply dialysate with a simple configuration. The apparatus 400 can be cleaned and disinfected. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
  • the dialysate supply device 800 of this embodiment is a second connector connected to the lower neck portions 21Cb and 21Db of the detergent containers 21C and 21D in the dialysate supply device 300 described above with reference to FIGS.
  • a liquid backflow mechanism 801 for backflowing the cleaning / disinfecting liquid is added to the first connector 26a connected to the upper neck portions 21Ca and 21Da of the cleaning agent containers 21C and 21D from 26b.
  • control unit 95 of the dialysate supply apparatus 800 fills the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D into the containers 21A to 21D by optical means or the like from the outside.
  • a signal of a filling state detection sensor 21S for detecting an object is output.
  • the dialysate supply device 800 of this embodiment branches from the upstream side of the valve 24 arranged in the inlet pipe 22 and connects between the valve 25 of the outlet pipe 23 and the second connector 26b.
  • a valve 24a is disposed in the first bypass pipe 22a, and a valve 25a is disposed in the second bypass pipe 23a.
  • the first bypass pipe 22a, the second bypass pipe 23a, the valves 24a and 25a, and the inlet pipe 22, the outlet pipe 23, and the valves 24 and 25 flow back the cleaning / disinfecting liquid from the second connector 26b to the first connector 26a.
  • the liquid reverse flow mechanism 801 is configured.
  • the dialysate supply apparatus 800 of the present embodiment determines whether or not there is a filler in the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D set in the storage unit 720.
  • a filling state detection sensor 21S to be detected is attached.
  • the filling state detection sensor 21S detects whether or not the containers 21A to 21D are filled with powder or liquid and outputs the signal to the control unit 95 shown in FIG.
  • the filling state detection sensor 21S applies light to each of the containers 21A to 21D that has been rotated to the installation position of the filling state detection sensor 21S, and the presence or absence of a filling by the transmitted light.
  • the filling state detection sensor 21S is not limited to a transmissive optical sensor, and may be, for example, an LED light absorption sensor that uses a characteristic that infrared light is absorbed by a liquid, a color identification sensor, a reflection type sensor, or the like. It may be a photoelectric sensor or the like.
  • the filling state detection sensor 21S detects the filling of each container 21A to 21D when the center line of each container 21A to 21D rotates to a position where it matches the center line 580 of the first connector 26a and the second connector 26.
  • the presence / absence detection may be performed, or the presence / absence of the filling in each of the containers 21A to 21D may be detected while the containers 21A to 21D set in the storage unit 720 are rotating.
  • the operation of the dialysate supply device 800 configured as described above and a method for cleaning and disinfecting the liquid contact portion of the dialysate supply device 800 by attaching the cleaning agent container 21C to the medicine charging mechanism 20 will be described.
  • the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D are set in the holes 701 to 704 of the storage unit 720 as shown in FIG. To do.
  • the dialysate supply device 800 is provided with the filling state detection sensor 21S for detecting the filling state of the containers 21A to 21D. Then, as shown in FIG. 21, a signal from the filling state detection sensor 21 ⁇ / b> S is output to the control unit 95.
  • the control unit 95 stops the operation of the dialysate supply device 800 and sends it to the dialyzer 96. Stop supplying the dialysate. If necessary, an alarm that an empty agent container 21A or an empty agent B container 21B is set in the storage unit 720 is issued.
  • dialysate outside the appropriate concentration range is supplied, and after the start of dialysis treatment, the dialysate supply is stopped by an electrical conductivity sensor (not shown) attached to the dialysate supply device 800, and the treatment time is delayed. The interruption and discontinuation of treatment can be suppressed.
  • the controller 95 According to the signal from the filling state detection sensor 21S arranged in the storage unit 720, the controller 95 is not empty, and the cleaner container 21C is sufficiently filled with the cleaning / disinfectant. After confirming that there is a control, the control unit 95 rotates the storage unit 720 so that the center of the cleaning agent container 21C is the first, second connector 26a, as described above with reference to FIGS. After the same as the center line 580 of 26b, the connector moving mechanism 560 is operated to attach the cleaning agent container 21C between the first connector 26a and the second connector 26b.
  • the cleaning / disinfecting agent filled in the cleaning agent container 21C When the cleaning / disinfecting agent filled in the cleaning agent container 21C is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 21C to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 23 through the flow holes 605 and 604 of the lower nozzle 603, through the flow holes 602 of the flat plate 601. Then, as shown in a flow path R31 of FIG.
  • the water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
  • the cleaning / disinfecting liquid stored in the tank 15 is like a flow path R32 indicated by a one-dot chain line in FIG. [Tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate supply pipe 73 ⁇ recirculation pipe 78 (valve 79) ⁇ RO water pipe 13 ⁇ drug injection mechanism 20 ⁇ drug injection pipe 14 ⁇ Tank 15] to circulate and clean and disinfect the wetted parts of each device and piping.
  • the cleaning / disinfecting liquid flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603, and cleans the inner surface of the third fitting hole 615. I do.
  • the cleaning / disinfecting liquid also flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603 to clean and disinfect the inner surface of the third fitting hole 615.
  • the cleaning / disinfecting liquid that has flowed into the cleaning agent container 21C flows from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503 to the flow hole 502 of the flat plate 501 of the first connector 26a. Go.
  • the cleaning / disinfecting liquid that has flowed into the cleaning agent container 21 ⁇ / b> C is a space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503 from the gap between the upper nozzle 503 and the sealing member 21 ⁇ / b> Cc of the upper neck portion 21 ⁇ / b> Ca.
  • the inner surface of the first fitting hole 515 is cleaned and disinfected.
  • the cleaning / disinfecting liquid stored in the tank 15 is completely drained from the drain by the flow path R33 shown in FIG. 17 as described above with reference to FIG.
  • the primary cleaning of the dialysate supply device 800 in contact with the liquid is finished by discharging to the outside.
  • the dialysate supply device 800 of the present embodiment forms the flow path R32a shown in FIG. 25 by the liquid backflow mechanism 801, and supplies the cleaning / disinfectant liquid from the lower second connector 26b to the upper first.
  • the flow is reversed toward the connector 26a. Accordingly, when the cleaning / disinfecting liquid is circulated in the flow path R32 shown in FIG. 23, the space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503, which are likely to be insufficiently cleaned and disinfected.
  • the cleaning / disinfecting liquid can be poured into the first fitting hole 515 to sufficiently clean and disinfect the inner surface of the first fitting hole 515.
  • the cleaning agent containers 21C and 21D are filled with powdery cleaning / disinfecting agent and dissolved with RO water to obtain a predetermined concentration of cleaning / disinfecting solution.
  • the cleaning agent containers 21C and 21D are filled with a liquid cleaning / disinfecting liquid, whereby the dialysate supply device 800 is cleaned and disinfected.
  • the lower neck portion 21Cb of the cleaning agent container 21C is fitted into the packing 618 of the fourth fitting hole 617, and the fourth fitting is configured by the outer surface of the lower neck portion 21Cb and the packing 618 of the fourth fitting hole 617.
  • the dialysate supply device 800 of the present embodiment is configured so that the lower nozzle 603 fits the lower neck portion 21 ⁇ / b> Cb of the cleaning agent container 21 ⁇ / b> C into the fourth fitting hole 617 in a watertight manner.
  • the gap between the tip of the lower nozzle 603 and the sealing member 21Cd After the lower neck portion 21Cb and the fourth fitting portion of the cleaning agent container 21C are watertight, there is a gap S, and the tip of the lower nozzle 603 is disposed so as to penetrate the sealing member 21Cd that seals the end surface of the lower neck portion 21Cb. Has been.
  • the cleaning agent container 21C can be attached to the medicine charging mechanism 20 without leaking the cleaning / disinfecting liquid to the outside.
  • the dialysate supply device 850 of this embodiment is configured so that the cleaning / disinfectant solution flows backward from the second connector 126b of the dialysate supply device 400 described above with reference to FIGS. 18 to 20 to the first connector 126a.
  • Liquid backflow mechanisms 802 and 803 for backflowing the cleaning / disinfecting liquid by the liquid feed pump 70 and the B agent injection pump 44 are added.
  • parts similar to those of the dialysate supply apparatus 400 described above with reference to FIGS. 18 to 20 are denoted by the same reference numerals, and description thereof is omitted.
  • valves 70a and 70b are arranged on the upstream side and the downstream side of the liquid feed pump 70 of the heater inlet pipe 71, and the upstream side of the upstream valve 70a.
  • the first pump bypass pipe 71a branching from the liquid feed pump 70 and the valve 70b, and the first pump bypass pipe 71a branching from between the inlet of the liquid feed pump 70 and the valve 70a to join the downstream side of the valve 70b.
  • valves 70a to 70d and the first and second pump bypass pipes 71a and 71b constitute a liquid backflow mechanism 802 that allows the cleaning / disinfecting liquid to flow backward by the liquid feeding pump 70.
  • valves 125a and 125b are arranged on the upstream side and the downstream side of the B agent injection pump 44 in the outlet pipe 123, branch from the upstream side of the upstream valve 125a, and between the B agent injection pump 44 and the valve 125b.
  • a first pump bypass pipe 123a that merges and a second pump bypass pipe 123b that branches from the inlet of the B agent injection pump 44 and the valve 125a and merges downstream of 125b are arranged, and the first pump bypass pipe A valve 123c is arranged at 123a, and a valve 125d is arranged at the second pump bypass pipe 123b.
  • the valves 125 a to 125 d and the first and second pump bypass pipes 123 a and 123 b constitute a liquid backflow mechanism 803 that causes the cleaning / disinfecting liquid to flow back by the B agent injection pump 44.
  • FIG. 29 As shown in FIG. 29, when the valves 70a, 70b, 125a, and 125b are opened and the valves 70c, 70d, 125c, and 125d are closed, and the liquid feeding pump 70 and the B agent infusion pump are operated, FIG. As in the flow path R42a, the cleaning / disinfecting agent flows in the cleaning agent container 21C from the first connector 126a toward the second connector 126b. The flow of the cleaning / disinfectant in the cleaning agent container 21C at this time is the same as described with reference to FIG.
  • FIG. 30 when the valves 70 a, 70 b, 125 a, 125 b are closed and the valves 70 c, 70 d, 125 c, 125 d are opened and the liquid feed pump 70 and the B agent injection pump are operated, one point is shown in FIG. 30.
  • the cleaning / disinfecting agent flows in the reverse direction through the cleaning agent container 21C from the second connector 126b toward the first connector 126a.
  • the flow of the cleaning / disinfectant in the cleaning agent container 21C at this time is the same as described with reference to FIG.
  • the dialysate supply device 850 described above forms a flow path R42b indicated by a one-dot chain line in FIG. 30 by the liquid backflow mechanisms 802 and 803 as in the dialysate supply device 800 described above, and the cleaning / disinfecting solution is placed on the lower side. Back flow from the second connector 126b toward the upper first connector 126a. Accordingly, when the cleaning / disinfecting liquid is circulated in the flow path R32 shown in FIG. 23, the space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503, which are likely to be insufficiently cleaned and disinfected. The cleaning / disinfecting liquid can be poured into the first fitting hole 515 to sufficiently clean and disinfect the inner surface of the first fitting hole 515.
  • the liquid backflow mechanisms 802 and 803 are not provided, but the liquid feed pump 70 and the B agent injection pump 44 are reversed, and the flow path of FIG.
  • the cleaning / disinfectant may be caused to flow like a flow path R42b shown by a one-dot chain line in FIG. 30 so that the cleaning / disinfecting liquid flows backward from the lower second connector 126b toward the upper first connector 126a. .
  • the dialysate supply device 900 uses the dialysate supply device 300 described above with reference to FIGS. 10 to 17 as the tank for the medicine input mechanism 20 disposed between the RO device 12 and the tank 15.
  • the RO water stored in the tank 15 is circulated to the medicine charging mechanism 20 by the liquid feed pump 170 and stored in the tank 15 as a cleaning / disinfecting liquid for cleaning / disinfecting the liquid contact part. It is.
  • the liquid feed pump 170 is a diaphragm pump.
  • the dialysate supply device 900 of this embodiment includes a filling state detection sensor 21S that detects the filling state of each of the containers 21A to 21D, similarly to the dialysate supply device 800 described above with reference to FIG. Yes.
  • a filling state detection sensor 21S that detects the filling state of each of the containers 21A to 21D, similarly to the dialysate supply device 800 described above with reference to FIG. Yes.
  • the RO device 12 and the tank 15 are connected by an RO water pipe 13, and a check valve 13 a is arranged in the RO water pipe 13. ing.
  • the medicine charging mechanism 20 is arranged in parallel with the tank 15 so that the first connector 26a is on the lower side and the second connector 26b is on the upper side. Further, the medicine charging mechanism 20 is disposed at a position higher than the ceiling surface of the tank 15.
  • the first connector 26 a and the lower portion of the tank 15 are connected by an inlet pipe 22, and a liquid feed pump 170 is disposed in the inlet pipe 22.
  • an outlet pipe 23 is connected to the second connector 26 b, and the outlet pipe 23 is connected to the medicine input pipe 14 connected to the upper part of the tank 15.
  • the inlet pipe 22 and the upper part of the tank 15 are connected by a liquid drain pipe 14a.
  • the in-container liquid drain pipe 14a is disposed at a position higher than the ceiling surface of the tank 15, and the in-container liquid drain pipe 14a is provided with an in-container liquid drain pipe 14b.
  • a valve 77a is disposed on the coupler 81 side of the connection pipe 76 of the dialysate supply apparatus 900 of the present embodiment, and the upstream side of the valve 77a and the dialysate discharge pipe 80 are connected by a bypass pipe 80a.
  • a valve 80b is disposed in the bypass pipe 80a.
  • a second recirculation pipe 78a is arranged between the downstream side of the liquid feed pump 70 and the recirculation pipe 78, and a valve 79a is arranged in the second recirculation pipe 78a.
  • the cleaning agent container 21C is filled with a cleaning agent
  • the cleaning agent container 21D is filled with a disinfectant.
  • the cleaning agent and disinfectant may be powder or liquid.
  • the valve 77a, the valve 80b, and the liquid draining valve 14b are first closed, and the cleaning agent containers 21C and 21D are set in the storage unit 720. 32, the RO water generated by the RO device 12 by the water supply pump 11 is sent to the tank 15 as shown by the solid line R31a in FIG.
  • the storage unit 720 is rotated so that the center line of the cleaning agent container 21C is aligned with the center line 580 of the first connector 26a and the second connector 26b.
  • the liquid crystal is sandwiched between the connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path.
  • the liquid feed pump 170 is a diaphragm pump, and since the liquid drain valve 14b is closed, the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated with each other.
  • the liquid cleaning agent filled in the cleaning agent container 21C does not move downward.
  • the liquid feed pump 170 is started, the liquid cleaning agent filled in the cleaning agent container 21C is stored in the tank 15 from the medicine charging pipe 14 as shown by a flow path R31b indicated by a solid line in FIG. Mix in the RO water.
  • the cleaning agent container 21C is filled with a powdery cleaning agent, the powdery cleaning agent is dissolved in the RO water flowing into the cleaning agent container 21C to form a liquid cleaning agent. Mix with RO water stored in tank 15. At this time, the RO water flows from the lower side to the upper side of the cleaning agent container 21C from the first connector 26a toward the second connector 26b.
  • the cleaning agent in the cleaning agent container 21 ⁇ / b> C is mixed with the RO water in the tank 15.
  • the liquid feed pump 170 is stopped and the in-container draining valve 14b is opened as shown in FIG. Then, as shown in a flow path R31c indicated by a one-dot chain line in FIG. 34, the liquid remaining in the cleaning agent container 21C is as [cleaning agent container 21C ⁇ in-container drain pipe 14a ⁇ tank 15]. , Move into the tank 15 by gravity. When the liquid in the cleaning agent container 21C is discharged to the tank 15, the container draining valve 14b is closed.
  • the first connector 26a is moved upward and the second connector 26b is moved to separate the first and second connectors 26a and 26b from the cleaning agent container 21C, and then the storage unit 720 is rotated.
  • the center line of the cleaning agent container 21D is aligned with the center line 580 of the first connector 26a and the second connector 26b.
  • the cleaning agent container 21D is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21D, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path.
  • the liquid feed pump 170 is a diaphragm pump, and the liquid draining valve 14b is closed.
  • the cleaning agent container 21D, the inlet pipe 22, and the outlet pipe are closed. Even if 23 is connected to form one liquid flow path, the disinfectant filled in the cleaning agent container 21D does not move downward. Thereafter, when the liquid feed pump 170 is started, the powdery or liquid disinfectant in the cleaning agent container 21D is mixed into the tank 15 as shown by a flow path R31b indicated by a solid line in FIG. When the liquid feed pump 170 is operated for a predetermined time, a cleaning / disinfecting solution for cleaning / disinfecting the liquid contact portion is stored in the tank 15.
  • the liquid feed pump 170 is stopped, and the liquid draining valve as shown in FIG. 14b is opened, the liquid remaining in the cleaning agent container 21D is discharged to the tank 15, and then the liquid draining valve 14b is closed.
  • the liquid feeding pump 170 is stopped and the liquid feeding pump 70 is started.
  • the cleaning / disinfecting solution stored in the tank 15 is [tank 15 ⁇ pump suction pipe 16 ⁇ feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ Dialyzing fluid supply pipe 73 ⁇ recirculation pipe 78 (valve 79) ⁇ RO water pipe 13 (check valve 13a) ⁇ tank 15] circulates.
  • the cleaning / disinfection of the flow path R32c shown in FIG. 35 is performed for a predetermined time, the cleaning / disinfection of the flow path R32c is ended.
  • the valve 79a may be opened to allow the cleaning / disinfecting liquid to flow through the second recirculation pipe 78a.
  • the valve 80b is opened as shown in FIG. 36, and the used is stored in the tank 15 as shown by the flow path R32d shown by a one-dot chain line in FIG. Washing / disinfecting liquid flows through [tank 15 ⁇ pump suction pipe 16 ⁇ liquid feed pump 70 ⁇ heater inlet pipe 71 ⁇ heater 72 ⁇ dialysate supply pipe 73 ⁇ bypass pipe 80a (valve 80b) ⁇ dialysate discharge pipe 80]. Then drain it out of the system. At this time, the liquid draining valve 14b may be opened, and the liquid remaining in the cleaning agent container 21C or the cleaning agent container 21D may be discharged to the tank 15.
  • the dialysate supply device 900 of the present embodiment has the same effects as the dialysate supply device 300 described with reference to FIGS.
  • the dialysate supply device 900 of the present embodiment has the medicine injection mechanism 20 disposed at a position higher than the ceiling surface of the tank 15, after mixing the cleaning agent and the disinfectant with the RO water in the tank 15, The liquid remaining in the cleaning agent containers 21 ⁇ / b> C and 21 ⁇ / b> D can be easily discharged to the tank 15.
  • the liquid feed pump 170 has been described as a diaphragm pump, but may be constituted by other types of reciprocating pumps.
  • the liquid feed pump 170 of the dialysate supply apparatus 900 described with reference to FIGS. 31 to 36 is a liquid feed pump 170a that is a centrifugal pump, and the in-container drain pipe 14a and the in-container liquid
  • the valve 24 is arranged in the inlet pipe 22 without providing the extraction valve 14b.
  • the same parts as those described with reference to FIGS. 31 to 36 are denoted by the same reference numerals, and description thereof is omitted.
  • the storage unit 720 is rotated so that the center line of the cleaning agent container 21C is aligned with the center lines 580 of the first connector 26a and the second connector 26b.
  • the agent container 21C is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path.
  • the valve 24 is opened and the liquid feed pump 170a is started, the cleaning agent filled in the cleaning agent container 21C is mixed into the RO water stored in the tank 15 from the drug introduction pipe 14.
  • the liquid feeding pump 170a is stopped with the valve 24 being open.
  • the liquid remaining in the cleaning agent container 21C moves from the cleaning agent container 21C to the tank 15 through the valve 24 and the centrifugal liquid feed pump 170a due to a drop between the tank 15 and the liquid level.
  • the liquid remaining in the detergent container 21D is mixed with the tank 15. Is moved to the tank 15 by the drop in the liquid level.
  • the liquid feed pump 70 is started to clean and disinfect the flow path R32c indicated by a one-dot chain line in FIG.
  • the used cleaning / disinfecting liquid stored in the tank 15 is discharged from the drain to the outside, as in the flow path R32d indicated by a one-dot chain line in FIG.
  • the dialysate supply device 910 of this embodiment has the same effect as the dialysate supply device 900 described with reference to FIGS.

Abstract

A dialysate supply device (100) is provided with a detergent charging mechanism (30) by which a detergent/disinfectant for cleaning/disinfecting a liquid-contact part coming into contact with dialysate in the dialysate supply device is charged into a reverse osmosis (RO) water pipeline (13) through which a dilution solution passes, wherein the detergent charging mechanism (30) is configured in such a manner that a detergent container (31) which holds a detergent/disinfectant therein is interposed between an inlet pipe (32) of the detergent container (31) and an outlet pipe (33) of the detergent container (31) such that the detergent container (31), the inlet pipe (32), and the outlet pipe (33) are connected to form a single fluid flow channel. This provides a dialysate supply device which has a simplified structure and which enables an operator to conduct cleaning/disinfection of the fluid flow channel with ease.

Description

透析液供給装置Dialysate supply device
　本発明は、透析液供給装置の構造に関する。 The present invention relates to the structure of a dialysate supply device.
　従来から複数の薬剤及び希釈液（例えば水）を混合して透析液を生成し、透析装置に供給する透析液供給装置が用いられている。このような透析液供給装置としては、二種類のパウダー状の薬剤の入ったバッグに所定量の水を導入してバッグ内のパウダーを溶解して透析液を生成した後、透析液を容器に貯留しておき、容器に貯留した透析液を吸引チューブで吸引して透析回路に供給する装置（例えば、特許文献１参照）や、薬剤が収容されたカートリッジを装置のホルダに装着し、このカートリッジに計量した水を注入して所定濃度の透析液を作るものが用いられている（例えば、特許文献２参照）。 Conventionally, a dialysate supply device that mixes a plurality of drugs and a diluent (for example, water) to generate a dialysate and supplies the dialysate to the dialyzer has been used. As such a dialysate supply device, a predetermined amount of water is introduced into a bag containing two kinds of powdered medicines to dissolve the powder in the bag to generate a dialysate, and then the dialysate is put into a container. A device that stores the dialysis fluid stored in the container and sucks it with a suction tube and supplies it to the dialysis circuit (see, for example, Patent Document 1) or a cartridge containing a medicine is mounted on the holder of the device. What is used is to inject metered water into a dialysate having a predetermined concentration (for example, see Patent Document 2).
　このような、透析液供給装置の液流路は、透析終了後に次亜塩素酸ナトリウム溶液や酢酸系溶液等の洗浄・消毒剤によって洗浄・消毒することが必要である。例えば、特許文献１に記載された装置では、装置内を空にした後、容器に殺菌剤を投入し、ポンプによってシステム全体に殺菌剤を循環させて液流路の洗浄を行うようにしている。また、特許文献２に記載されたような透析液供給装置では、薬液ボトルから薬液吸引ラインと薬液吸引ポンプを用いて薬液ボトル内の洗浄・消毒剤を配管内に注入し、薬剤カートリッジをバイパスする配管を用いて液流路に洗浄・消毒剤を循環させ液流路の洗浄を行うことが多い。 Such a liquid flow path of the dialysate supply apparatus needs to be cleaned and disinfected with a cleaning / disinfectant such as a sodium hypochlorite solution or an acetic acid based solution after completion of dialysis. For example, in the apparatus described in Patent Document 1, after the inside of the apparatus is emptied, a sterilizing agent is put into a container, and the sterilizing agent is circulated through the entire system by a pump to clean the liquid flow path. . Moreover, in the dialysate supply apparatus as described in Patent Document 2, the cleaning / disinfecting agent in the chemical solution bottle is injected into the pipe from the chemical solution bottle using the chemical solution suction line and the chemical solution suction pump, thereby bypassing the drug cartridge. In many cases, a cleaning / disinfectant is circulated in the liquid flow path using piping to clean the liquid flow path.
特許第５３５２４５３号明細書Japanese Patent No. 5352453 特許第３８４８３７１号明細書Japanese Patent No. 3848371
　ところで、特許文献１、２に記載されているような透析液供給装置では、原液或いは規定濃度の洗浄・消毒剤を別容器から装置内の容器或いは、薬液ボトルに移し替えることが必要となる。この際、操作者は、洗浄・消毒剤に接触しないように慎重に作業する必要があり、装置の洗浄・消毒作業に時間と手間が掛ってしまうという問題があった。また、洗浄・消毒剤を注入する為の専用の配管、弁等が必要となり、装置が複雑化してしまうという問題があった。 By the way, in the dialysate supply apparatus as described in Patent Documents 1 and 2, it is necessary to transfer the stock solution or the cleaning / disinfectant having a specified concentration from another container to a container in the apparatus or a chemical solution bottle. At this time, the operator needs to work carefully so as not to come into contact with the cleaning / disinfecting agent, and there is a problem that it takes time and effort to clean and disinfect the apparatus. In addition, dedicated piping and valves for injecting the cleaning / disinfectant are required, which complicates the apparatus.
　そこで、本発明は、簡便な構成で操作者が容易に液流路の洗浄・消毒作業を行うことができる透析液供給装置を提供することを目的とする。 Therefore, an object of the present invention is to provide a dialysate supply apparatus that allows an operator to easily perform cleaning and disinfection of a liquid flow path with a simple configuration.
　本開示の透析液供給装置は、薬剤と希釈液とを混合して透析液を生成し、前記透析液を透析装置に供給する透析液供給装置であって、前記透析液に接する接液部を洗浄・消毒する洗浄・消毒剤を、前記希釈液が通流する配管の中に投入する洗浄剤投入機構を備え、前記洗浄剤投入機構は、前記洗浄・消毒剤を収容した洗浄剤容器と、前記洗浄剤容器の一端側の配管と、前記洗浄剤容器の他端側の配管とが連通して１つの液体流路を形成するように、一端側の配管と他端側の配管との間に前記洗浄剤容器を挟み込むことを特徴とする。 The dialysate supply device of the present disclosure is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer, and has a wetted part in contact with the dialysate The cleaning / disinfecting agent for cleaning / disinfecting is provided with a cleaning agent charging mechanism for charging the diluent into the pipe through which the diluent flows, and the cleaning agent charging mechanism includes a cleaning agent container containing the cleaning / disinfecting agent, Between the pipe on one end side and the pipe on the other end side so that the pipe on one end side of the cleaning agent container and the pipe on the other end side of the cleaning agent container communicate with each other to form one liquid channel. The cleaning agent container is sandwiched between the two.
　本開示の透析液供給装置において、根元側が一端側の配管に接続され、先端側が前記洗浄剤容器の一端側に突出する上首部の外周に水密に嵌り込む環状の上コネクタと、前記上コネクタと同軸に配置され、根元側が他端側の配管に接続され、先端側が前記洗浄剤容器の他端側に突出する下首部の外周に水密に嵌り込む環状の下コネクタと、前記上または下コネクタのいずれか一方または両方を前記洗浄剤容器の長手方向に沿って移動させるコネクタ移動機構と、を備え、前記各コネクタは、その環状中心近傍に前記各首部の各端面をそれぞれシールするシール部材を貫通するノズルを備えることとしてよい。 In the dialysate supply device of the present disclosure, an annular upper connector in which a root side is connected to a pipe on one end side, and a tip end side is watertightly fitted to an outer periphery of an upper neck portion protruding to one end side of the cleaning agent container, and the upper connector An annular lower connector that is coaxially disposed, has a root side connected to a pipe on the other end side, and a tip end side that is watertightly fitted to the outer periphery of the lower neck protruding to the other end side of the cleaning agent container, and the upper or lower connector A connector moving mechanism that moves either or both along the longitudinal direction of the cleaning agent container, and each connector penetrates a sealing member that seals each end face of each neck near the annular center. It is good also as providing the nozzle to do.
　本開示の透析液供給装置は、薬剤と希釈液とを混合して透析液を生成し、前記透析液を透析装置に供給する透析液供給装置であって、前記薬剤を前記希釈液が通流する配管の中に投入する薬剤投入機構を備え、前記薬剤投入機構は、前記薬剤を収容した薬剤容器と、前記薬剤容器の一端側の配管と、前記薬剤容器の他端側の配管とが連通して１つの液体流路を形成するように、一端側の配管と他端側の配管との間に前記薬剤容器を挟み込み可能であると共に、前記薬剤容器に代えて、前記透析液に接する接液部を洗浄・消毒する洗浄・消毒剤を収容した洗浄剤容器を一端側の配管と他端側の配管との間に挟み込み可能であることを特徴とする。 A dialysate supply device according to the present disclosure is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer. And a medicine container that houses the medicine, a pipe on one end side of the medicine container, and a pipe on the other end side of the medicine container. Thus, the drug container can be sandwiched between the pipe on one end side and the pipe on the other end side so as to form one liquid flow path, and in contact with the dialysate instead of the drug container. A cleaning agent container containing a cleaning / disinfecting agent for cleaning / disinfecting the liquid part can be sandwiched between a pipe on one end side and a pipe on the other end side.
　本開示の透析液供給装置において、前記薬剤投入機構は、根元側が一端側の配管に接続され、先端側が前記薬剤容器の一端側に突出する第１首部の第１外周に水密に嵌り込む第１嵌合部と、前記洗浄剤容器の一端側に突出する第２首部の第２外周に水密に嵌り込む第１嵌合部と形状の異なる第２嵌合部と、を含む環状の第１コネクタと、前記第１コネクタと同軸に配置され、根元側が他端側の配管に接続され、先端側が前記薬剤容器の他端側に突出する第３首部の第３外周に水密に嵌り込む第３嵌合部と、前記洗浄剤容器の他端側に突出する第４首部の第４外周に水密に嵌り込む第３嵌合部と形状の異なる第４嵌合部と、を含む環状の第２コネクタと、前記第１または第２コネクタのいずれか一方または両方を前記薬剤容器または前記洗浄剤容器の長手方向に沿って移動させるコネクタ移動機構と、を備え、前記第１コネクタおよび前記第２コネクタは、その環状中心近傍に前記各首部の各端面をそれぞれシールするシール部材を貫通するノズルを備えることとしてもよい。 In the dialysate supply device according to the present disclosure, the drug charging mechanism includes a first fitting that is watertightly fitted to a first outer periphery of a first neck portion having a root side connected to a pipe on one end side and a tip side protruding to one end side of the drug container. An annular first connector including a fitting portion, and a second fitting portion having a different shape from a first fitting portion that fits in a watertight manner on a second outer periphery of a second neck portion protruding toward one end of the cleaning agent container. And a third fitting that is arranged coaxially with the first connector, has a root side connected to a pipe on the other end side, and a tip end side that is watertightly fitted to the third outer periphery of the third neck portion protruding to the other end side of the drug container. An annular second connector including a joint portion, and a fourth fitting portion having a different shape from a third fitting portion that fits in a watertight manner on the fourth outer periphery of the fourth neck portion protruding to the other end side of the cleaning agent container And either one or both of the first and second connectors are connected to the medicine container or the washing And a connector moving mechanism that moves along the longitudinal direction of the container, wherein the first connector and the second connector have nozzles that pass through seal members that seal the respective end faces of the neck portions in the vicinity of the annular center. It is good also as providing.
　本開示の透析液供給装置において、前記第１コネクタの前記第２嵌合部は、その内径が前記第１嵌合部よりも大きく、前記第１嵌合部よりも前記第１コネクタの前記先端側に配置されており、前記第２コネクタの前記第４嵌合部は、その内径が前記第３嵌合部よりも大きく、前記第３嵌合部よりも前記第２コネクタの前記先端側に配置されていることとしてもよい。 In the dialysate supply device of the present disclosure, the inner diameter of the second fitting portion of the first connector is larger than that of the first fitting portion, and the tip of the first connector is larger than the first fitting portion. The fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is closer to the distal end side of the second connector than the third fitting portion. It may be arranged.
　本開示の透析液供給装置において、少なくとも１つの前記薬剤容器と少なくとも１つの前記洗浄剤容器とを保持するストレージ部と、前記ストレージ部からいずれか１つの容器を前記第１コネクタと前記第２コネクタとの間に移送する送り機構と、を備えることとしてもよい。 In the dialysis fluid supply device of the present disclosure, a storage unit that holds at least one of the drug container and at least one cleaning agent container, and any one container from the storage unit is connected to the first connector and the second connector. It is good also as providing the feeding mechanism transferred between.
　本開示の透析液供給装置において、前記ストレージ部は、前記薬剤容器を保持する第１穴と、前記洗浄剤容器を保持する第１穴と形状の異なる第２穴と、を備えることとしてもよい。 In the dialysate supply device of the present disclosure, the storage unit may include a first hole that holds the drug container and a second hole that has a different shape from the first hole that holds the cleaning agent container. .
　本開示の透析液供給装置において、前記薬剤容器または前記洗浄剤容器に取り付けられて前記薬剤容器または前記洗浄剤容器の充填状態を検出する充填状態検出センサと、前記充填状態検出センサからの信号が入力される制御部と、を備え、前記制御部は、前記充填状態検出センサからの信号に基づいて前記薬剤容器または前記洗浄剤容器が空かどうかを判定すること、としてもよい。 In the dialysate supply device of the present disclosure, a filling state detection sensor that is attached to the medicine container or the cleaning agent container and detects a filling state of the medicine container or the cleaning agent container, and a signal from the filling state detection sensor An input control unit, and the control unit may determine whether the drug container or the cleaning agent container is empty based on a signal from the filling state detection sensor.
　本開示の透析液供給装置において、液体を前記洗浄剤容器の他端側から一端側に逆流させる液体逆流機構を有すること、としてもよい。 The dialysate supply device according to the present disclosure may include a liquid backflow mechanism for backflowing the liquid from the other end side to the one end side of the cleaning agent container.
　本開示の透析液供給装置において、前記ノズルは、前記洗浄剤容器の前記第４首部を前記第４嵌合部に水密に嵌め込む際に、前記洗浄剤容器の前記第４首部と前記第４嵌合部とが水密となった後に、前記第４首部の端面をシールするシール部材を前記ノズルの先端が貫通するように配置されていること、としてもよい。 In the dialysate supply device according to the present disclosure, the nozzle is configured to fit the fourth neck portion of the cleaning agent container and the fourth portion when the fourth neck portion of the cleaning agent container is fitted into the fourth fitting portion in a watertight manner. It is good also as arrange | positioning so that the front-end | tip of the said nozzle may penetrate the sealing member which seals the end surface of the said 4th neck part after a fitting part becomes watertight.
　本発明は、簡便な構成で操作者が容易に液流路の洗浄・消毒作業を行うことができる透析液供給装置を提供することができる。 The present invention can provide a dialysate supply device that allows an operator to easily perform cleaning and disinfection of a liquid flow path with a simple configuration.
本開示の実施形態における透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the dialysate supply apparatus in embodiment of this indication. 本開示の実施形態における透析液供給装置に用いる洗浄剤容器、薬剤容器を示す断面図である。It is sectional drawing which shows the washing | cleaning agent container and chemical | medical agent container which are used for the dialysate supply apparatus in embodiment of this indication. 図１に示す透析液供給装置の洗浄剤投入機構の構成を示す断面図である。It is sectional drawing which shows the structure of the cleaning agent injection | throwing-in mechanism of the dialysate supply apparatus shown in FIG. 図３に示す洗浄剤投入機構に洗浄剤容器を取り付けた状態示す断面図である。It is sectional drawing which shows the state which attached the cleaning agent container to the cleaning agent injection | throwing-in mechanism shown in FIG. 図３に示す洗浄剤投入機構に洗浄剤容器を取り付けて図１に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す図である。FIG. 4 is a view showing a flow of a cleaning / disinfecting liquid when a cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and a wetted part of the dialysate supply apparatus shown in FIG. 1 is cleaned. 図３に示す洗浄剤投入機構に洗浄剤容器を取り付けて図１に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の他の流れを示す図である。FIG. 4 is a view showing another flow of the cleaning / disinfecting liquid when the cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and the liquid contact portion of the dialysate supply device shown in FIG. 1 is cleaned. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication. 図７に示す洗浄剤投入機構に洗浄剤容器を取り付けて図７に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す図である。It is a figure which shows the flow of the washing | cleaning and disinfection liquid at the time of attaching a washing | cleaning agent container to the washing | cleaning agent injection | throwing-in mechanism shown in FIG. 7, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 図７に示す洗浄剤投入機構に洗浄剤容器を取り付けて図７に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の他の流れを示す図である。It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container to the washing | cleaning agent injection | throwing-in mechanism shown in FIG. 7, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication. 図１０に示す透析液供給装置の薬剤投入機構の構成を示す断面図である。It is sectional drawing which shows the structure of the chemical | medical agent injection | throwing-in mechanism of the dialysate supply apparatus shown in FIG. 図１１に示す薬剤投入機構のストレージ部の上円板を示す平面図である。It is a top view which shows the upper disc of the storage part of the chemical | medical agent injection | throwing-in mechanism shown in FIG. 図１１に示す薬剤投入機構のストレージ部の下円板を示す平面図である。It is a top view which shows the lower disc of the storage part of the chemical | medical agent injection | throwing-in mechanism shown in FIG. 図１１に示す薬剤投入機構の第１、第２コネクタの構造を示す断面図である。It is sectional drawing which shows the structure of the 1st, 2nd connector of the chemical | medical agent injection | throwing-in mechanism shown in FIG. 図１３に示す第１、第２コネクタに薬剤容器を取り付けた状態示す断面図である。It is sectional drawing which shows the state which attached the chemical | medical agent container to the 1st, 2nd connector shown in FIG. 図１３に示す第１、第２コネクタに洗浄剤容器を取り付けた状態示す断面図である。It is sectional drawing which shows the state which attached the cleaning agent container to the 1st, 2nd connector shown in FIG. 図１５に示す第１、第２コネクタ間に洗浄剤容器を取り付けて図１０に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す図である。It is a figure which shows the flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container between the 1st, 2nd connectors shown in FIG. 15, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 図１５に示す第１、第２コネクタの間に洗浄剤容器を取り付けて図１０に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の他の流れを示す図である。It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container between the 1st, 2nd connectors shown in FIG. 15, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication. 薬剤投入機構に洗浄剤容器を取り付けて図１８に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す図である。It is a figure which shows the flow of the washing | cleaning and disinfection liquid at the time of attaching a cleaning agent container to a chemical | medical agent injection | throwing-in mechanism, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 薬剤投入機構に洗浄容器を取り付けて図１８に示す透析液供給装置の接液部を洗浄する際の洗浄・消毒液の他の流れを示す図である。It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning container to a chemical | medical agent injection | throwing-in mechanism, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication. 図２１に示す透析液供給装置の薬剤投入機構の構成を示す断面図である。It is sectional drawing which shows the structure of the chemical | medical agent injection | throwing-in mechanism of the dialysate supply apparatus shown in FIG. 図２１に示す透析液供給装置に洗浄剤容器を取り付けて透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す系統図である。It is a systematic diagram which shows the flow of the washing | cleaning and disinfection liquid at the time of attaching a cleaning agent container to the dialysate supply apparatus shown in FIG. 21, and wash | cleaning the liquid-contact part of a dialysate supply apparatus. 図２３に示すように洗浄・消毒液を流した際の第１、第２コネクタと洗浄剤容器の中の洗浄・消毒液の流れの状態を示す断面図である。It is sectional drawing which shows the state of the flow of the cleaning / disinfecting liquid in the first and second connectors and the cleaning agent container when the cleaning / disinfecting liquid flows as shown in FIG. 図２１に示す透析液供給装置に洗浄剤容器を取り付け、洗浄・消毒液を逆流させて透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す系統図である。FIG. 22 is a system diagram showing a flow of the cleaning / disinfecting liquid when a cleaning agent container is attached to the dialysate supplying apparatus shown in FIG. 21 and the cleaning / disinfecting liquid is made to flow backward to wash the liquid contact portion of the dialysate supplying apparatus. 図２５に示すように洗浄・消毒液を流した際の第１、第２コネクタと洗浄剤容器の中の洗浄・消毒液の流れの状態を示す断面図である。It is sectional drawing which shows the state of the flow of the cleaning / disinfecting liquid in the first and second connectors and the cleaning agent container when the cleaning / disinfecting liquid flows as shown in FIG. 図２１に示す透析液供給装置の第２コネクタに洗浄剤容器を取り付ける際における第２コネクタの嵌合部とノズルと洗浄剤容器のシール部材との位置関係を示す断面図である。It is sectional drawing which shows the positional relationship of the fitting part of a 2nd connector, a nozzle, and the sealing member of a cleaning agent container at the time of attaching a cleaning agent container to the 2nd connector of the dialysate supply apparatus shown in FIG. 図２１に示す透析液供給装置の第２コネクタに洗浄剤容器を取り付ける際における第２コネクタの嵌合部と他の形状のノズルと洗浄剤容器のシール部材との位置関係を示す断面図である。It is sectional drawing which shows the positional relationship of the fitting part of a 2nd connector, the nozzle of another shape, and the sealing member of a cleaning agent container at the time of attaching a cleaning agent container to the 2nd connector of the dialysate supply apparatus shown in FIG. . 本開示の実施形態における他の透析液供給装置の構成と洗浄剤投入機構に洗浄剤容器を取り付けて透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す系統図である。FIG. 4 is a system diagram showing the flow of the cleaning / disinfecting liquid when a cleaning agent container is attached to the configuration of the other dialysate supply device and the cleaning agent charging mechanism in the embodiment of the present disclosure to wash the liquid contact portion of the dialysate supply device. is there. 図２９に示す透析液供給装置に洗浄剤容器を取り付け、洗浄・消毒液を逆流させて透析液供給装置の接液部を洗浄する際の洗浄・消毒液の流れを示す系統図である。FIG. 30 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning agent container is attached to the dialysate supplying apparatus shown in FIG. 29 and the cleaning / disinfecting liquid is made to flow backward to wash the liquid contact portion of the dialysate supplying apparatus. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication. 図３１に示す透析液供給装置のタンクにＲＯ水を貯留する際のＲＯ水の流れを示す系統図である。It is a systematic diagram which shows the flow of RO water at the time of storing RO water in the tank of the dialysate supply apparatus shown in FIG. 図３１に示す透析液供給装置のタンク中のＲＯ水に洗浄・消毒液を混合させて透析液供給装置の接液部を洗浄する洗浄・消毒液とする際の洗浄・消毒液の流れを示す系統図である。FIG. 31 shows the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is mixed with the RO water in the tank of the dialysing liquid supplying apparatus shown in FIG. It is a systematic diagram. 図３１に示す透析液供給層に取り付けた洗浄剤容器の中の液体をタンクに排出する際の液体の流れを示す系統図である。It is a systematic diagram which shows the flow of the liquid at the time of discharging | emitting the liquid in the cleaning agent container attached to the dialysate supply layer shown in FIG. 31 to a tank. 図３１に示す透析液供給装置の接液部に洗浄・消毒液を流して洗浄・消毒する際の洗浄・消毒液の流れを示す系統図である。FIG. 32 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is allowed to flow through the wetted part of the dialysate supply apparatus shown in FIG. 31 to perform cleaning / disinfecting. 図３５に示す洗浄・消毒工程が終了した後、タンクから洗浄・消毒液を排出する際の洗浄・消毒液の流れを示す系統図である。FIG. 36 is a system diagram showing the flow of the cleaning / disinfecting liquid when the cleaning / disinfecting liquid is discharged from the tank after the cleaning / disinfecting process shown in FIG. 35 is completed. 本開示の実施形態における他の透析液供給装置の構成を示す系統図である。It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this indication.
　以下、図面を参照しながら本開示の実施形態の透析液供給装置１００について説明する。透析液供給装置１００は、タンク１５に所定濃度の透析液を生成、貯留し、貯留した透析液を透析装置９６に供給するバッチ式の透析液供給装置である。図１に示すように、透析液供給装置１００は、水道等の水の供給源から水を供給する水供給ポンプ１１と、逆浸透膜（ＲＯ膜）等を用いて純度の高いＲＯ水を生成するＲＯ装置１２と、透析液生成用の薬剤を希釈液であるＲＯ水の中に投入する薬剤投入機構６０と、透析液に接する接液部を洗浄・消毒する洗浄・消毒剤をＲＯ水の中に投入する洗浄剤投入機構３０と、生成した透析液を貯留するタンク１５と、タンク１５の透析液を透析装置９６に送り出す送液ポンプ７０と、透析装置９６に送る透析液を加温するヒータ７２と、各機器を接続する配管、弁、温度センサ７４、流量センサ７５、８３と、透析装置９６の透析液入口９１、透析液出口９２にそれぞれ接続されるカプラ８１、８２と、を含んでいる。ダイアライザ９０と透析液入口９１との間には、透析液を透析装置９６のダイアライザ９０に注入する透析液注入ポンプ９７ａ（透析液ＩＮポンプ）が配置され、ダイアライザ９０と透析液出口９２との間にはダイアライザ９０から透析液を排出する透析液排出ポンプ９７ｂ（透析液ＯＵＴポンプ）が配置されている。また、患者の血液は血液ポンプ９７ｃによって動脈から血液入口管９３を経てダイアライザ９０の血液入口に流入し、ダイアライザ９０の血液出口管９４から患者の静脈に戻る。 Hereinafter, the dialysate supply device 100 according to an embodiment of the present disclosure will be described with reference to the drawings. The dialysate supply device 100 is a batch-type dialysate supply device that generates and stores a predetermined concentration of dialysate in the tank 15 and supplies the stored dialysate to the dialyzer 96. As shown in FIG. 1, the dialysate supply device 100 generates high-purity RO water using a water supply pump 11 that supplies water from a water supply source such as tap water, a reverse osmosis membrane (RO membrane), and the like. RO device 12 for performing the treatment, a drug feeding mechanism 60 for feeding a drug for generating dialysate into RO water as a diluent, and a cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the dialysate The cleaning agent charging mechanism 30 to be charged therein, the tank 15 for storing the generated dialysate, the liquid feed pump 70 for sending the dialysate in the tank 15 to the dialyzer 96, and the dialysate to be sent to the dialyzer 96 are heated. A heater 72, pipes, valves, temperature sensors 74, flow sensors 75, 83 for connecting each device, and couplers 81, 82 connected to the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 96, respectively. It is out. Between the dialyzer 90 and the dialysate inlet 91, a dialysate injection pump 97a (dialysate IN pump) for injecting dialysate into the dialyzer 90 of the dialyzer 96 is disposed. Is provided with a dialysate discharge pump 97b (dialyte OUT pump) for discharging dialysate from the dialyzer 90. The blood of the patient flows from the artery through the blood inlet tube 93 to the blood inlet of the dialyzer 90 by the blood pump 97c, and returns to the patient's vein from the blood outlet tube 94 of the dialyzer 90.
　図１に示すように、水供給ポンプ１１とＲＯ装置１２とは水供給管１０で接続され、ＲＯ装置１２と薬剤投入機構６０、洗浄剤投入機構３０とはＲＯ水管１３で接続され、薬剤投入機構６０、洗浄剤投入機構３０とタンク１５とは薬剤投入管１４で接続され、タンク１５と送液ポンプ７０との間はポンプ吸込み管１６で接続され、送液ポンプ７０とヒータ７２とはヒータ入口管７１で接続され、ヒータ７２と弁７７との間は透析液供給管７３で接続され、弁７７とカプラ８１との間は接続管７６で接続されている。カプラ８２には、透析液排出管８０が接続されている。透析液供給管７３とＲＯ水管１３との間は、再循環管７８で接続されており、再循環管７８には弁７９が配置されている。透析液供給管７３には透析装置９６に供給する透析液の温度、流量を検出する温度センサ７４、流量センサ７５が取り付けられており、透析液排出管８０には、透析装置９６から排出された透析液の流量を検出する流量センサ８３が取り付けられている。また、本実施形態の透析液供給装置１００には、オプションとして図１に破線で示すように、透析液排出管８０に、もう一つの洗浄剤投入機構１３０が配置され、透析液排出管８０とＲＯ水管１３とはもう一つの再循環管１７８によって接続されており、再循環管１７８には弁１７９が配置されている。 As shown in FIG. 1, the water supply pump 11 and the RO device 12 are connected by a water supply pipe 10, and the RO device 12, the drug charging mechanism 60, and the cleaning agent charging mechanism 30 are connected by an RO water pipe 13, The mechanism 60, the cleaning agent charging mechanism 30 and the tank 15 are connected by a chemical charging pipe 14. The tank 15 and the liquid feeding pump 70 are connected by a pump suction pipe 16. The liquid feeding pump 70 and the heater 72 are heaters. Connected by an inlet pipe 71, the heater 72 and the valve 77 are connected by a dialysate supply pipe 73, and the valve 77 and the coupler 81 are connected by a connecting pipe 76. A dialysate discharge pipe 80 is connected to the coupler 82. The dialysate supply pipe 73 and the RO water pipe 13 are connected by a recirculation pipe 78, and a valve 79 is disposed in the recirculation pipe 78. The dialysate supply pipe 73 is provided with a temperature sensor 74 and a flow rate sensor 75 for detecting the temperature and flow rate of the dialysate supplied to the dialyzer 96. The dialysate discharge pipe 80 is discharged from the dialyzer 96. A flow sensor 83 for detecting the flow rate of the dialysate is attached. Further, in the dialysate supply apparatus 100 of the present embodiment, as indicated by a broken line in FIG. 1 as an option, another detergent charging mechanism 130 is disposed in the dialysate discharge pipe 80, and the dialysate discharge pipe 80 and The RO water pipe 13 is connected by another recirculation pipe 178, and a valve 179 is disposed in the recirculation pipe 178.
　薬剤投入機構６０は、希釈液であるＲＯ水が導入される入口管６２と、根元が入口管６２に接続されて先端が薬剤容器６１の一端に嵌まり込む上コネクタ６６ａと、薬剤投入管１４に接続される出口管６３と、根元が出口管６３に接続されて先端が薬剤容器６１の他端に嵌まり込む下コネクタ６６ｂと、入口管６２、出口管６３にそれぞれ配置される弁６４、６５によって構成されている。また、洗浄剤投入機構３０は、希釈液であるＲＯ水が導入される入口管３２と、根元が入口管３２に接続されて先端が洗浄剤容器３１の一端に嵌まり込む上コネクタ３６ａと、薬剤投入管１４に接続される出口管３３と、根元が出口管３３に接続されて先端が洗浄剤容器３１の他端に嵌まり込む下コネクタ３６ｂと、入口管３２、出口管３３にそれぞれ配置される弁３４、３５によって構成されている。 The drug injection mechanism 60 includes an inlet pipe 62 into which RO water as a diluent is introduced, an upper connector 66 a whose root is connected to the inlet pipe 62 and the tip fits into one end of the drug container 61, and the drug injection pipe 14. An outlet pipe 63 connected to the bottom, a lower connector 66b having a root connected to the outlet pipe 63 and a tip fitted into the other end of the drug container 61, a valve 64 disposed on the inlet pipe 62 and the outlet pipe 63, respectively. 65. The cleaning agent charging mechanism 30 includes an inlet pipe 32 into which RO water as a diluent is introduced, an upper connector 36a whose root is connected to the inlet pipe 32, and a tip is fitted into one end of the cleaning agent container 31; The outlet pipe 33 connected to the medicine injection pipe 14, the lower connector 36 b whose root is connected to the outlet pipe 33 and the tip fits into the other end of the cleaning agent container 31, the inlet pipe 32, and the outlet pipe 33 are arranged. It is comprised by the valves 34 and 35 to be performed.
　透析液として重炭酸透析液を用いる場合、透析液は、Ａ剤、Ｂ剤の二つの薬剤を混合・希釈して生成される。ここで、Ａ剤は、電解質成分（例えば塩化ナトリウム、塩化カリウム、塩化カルシウム、塩化マグネシウム、酢酸ナトリウム）や、ｐＨ調整剤（例えば酢酸）、糖（例えばグルコース）等を含む薬剤である。また、Ｂ剤は、重炭酸ナトリウム等を含む薬剤である。薬剤投入機構６０は、１回の透析液生成に必要な量のＡ剤またはＢ剤が充填された薬剤容器６１を各コネクタ６６ａ、６６ｂの間に取り付けることができる。Ａ剤およびＢ剤は、粉末状態や錠剤状態でもよいし、少量の希釈液で溶解した濃縮液状態でもよい。また、洗浄・消毒剤としては、次亜塩素酸ナトリウム溶液や酢酸系溶液等が用いられる。洗浄剤投入機構３０は、１回の洗浄・消毒に必要な洗浄剤或いは消毒剤が充填された洗浄剤容器３１を各コネクタ３６ａ、３６ｂの間に取り付けることができる。これらの洗浄・消毒剤も粉末状態や錠剤状態でもよいし、少量の希釈液で溶解した濃縮液状態でもよい。 When using a bicarbonate dialysate as the dialysate, the dialysate is generated by mixing and diluting two agents, agent A and agent B. Here, the agent A is an agent containing an electrolyte component (for example, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate), a pH adjuster (for example, acetic acid), a sugar (for example, glucose) and the like. Moreover, B agent is a chemical | medical agent containing sodium bicarbonate etc. The medicine charging mechanism 60 can attach a medicine container 61 filled with an amount of agent A or agent B necessary for generating dialysate once between the connectors 66a and 66b. The A agent and the B agent may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent. As the cleaning / disinfecting agent, a sodium hypochlorite solution or an acetic acid solution is used. The cleaning agent charging mechanism 30 can attach a cleaning agent container 31 filled with a cleaning agent or a disinfectant necessary for one cleaning / disinfection between the connectors 36a and 36b. These cleaning / disinfecting agents may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent.
　図２に示すように、洗浄剤容器３１は、円筒或いは四角筒で、洗浄・消毒剤を収容する本体３１ｅと、上方向に突出している円筒形の上首部３１ａと下方向に突出している円筒形の下首部３１ｂとを含んでいる。上首部３１ａの上端の開口と下首部３１ｂの下端の開口とはそれぞれシート状のシール部材３１ｃ、３１ｄによって封止されている。本体３１ｅの大きさは、洗浄・消毒剤の種類、１回の洗浄・消毒に必要な量によって適宜変更可能である。薬剤容器６１も洗浄剤容器３１と同様の形状であるが、図２に一点鎖線で示すように、上首部６１ａ、下首部６１ｂの外径が洗浄剤容器３１の上首部３１ａ、下首部３１ｂの外径と異なっている。また、本体６１ｅの大きさは、薬剤の種類、１回の透析液生成に必要な量によって変更される。 As shown in FIG. 2, the cleaning agent container 31 is a cylinder or a square tube, and includes a main body 31e for storing the cleaning / disinfecting agent, a cylindrical upper neck portion 31a protruding upward, and a cylinder protruding downward. And a lower neck portion 31b of the shape. The opening at the upper end of the upper neck portion 31a and the opening at the lower end of the lower neck portion 31b are sealed by sheet- like sealing members 31c and 31d, respectively. The size of the main body 31e can be appropriately changed according to the type of cleaning / disinfecting agent and the amount required for one cleaning / disinfecting. The drug container 61 has the same shape as the cleaning agent container 31, but the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the upper and lower neck portions 31a and 31b are as shown in FIG. It is different from the outer diameter. In addition, the size of the main body 61e is changed depending on the type of medicine and the amount required for one generation of dialysate.
　水供給ポンプ１１、送液ポンプ７０、洗浄剤投入機構３０、薬剤投入機構６０、ヒータ７２、弁７７、７９、１７９は、制御部９５に接続され、制御部９５の指令によって駆動或いは開閉される。また、温度センサ７４、流量センサ７５、８３の検出信号は、制御部９５に入力される。制御部９５は、内部に情報処理を行うＣＰＵと制御プログラムやデータを格納する記憶部を備えるコンピュータである。 The water supply pump 11, the liquid feed pump 70, the cleaning agent charging mechanism 30, the drug charging mechanism 60, the heater 72, the valves 77, 79, and 179 are connected to the control unit 95 and are driven or opened / closed according to commands from the control unit 95. . Further, detection signals from the temperature sensor 74 and the flow rate sensors 75 and 83 are input to the control unit 95. The control unit 95 is a computer that includes a CPU that performs information processing and a storage unit that stores control programs and data.
　次に、図３を参照しながら、洗浄剤投入機構３０の詳細構造について説明する。図３に示すように、洗浄剤投入機構３０は、上コネクタ３６ａと、上コネクタ３６ａと同軸に配置される下コネクタ３６ｂと、各コネクタ３６ａ、３６ｂを上下方向に駆動するコネクタ移動機構５６０と、入口管３２と、出口管３３と、入口管３２に配置された弁３４と、出口管３３に配置された弁３５とを含んでいる。上コネクタ３６ａは、上ベース５００と、上ベース５００の下面にボルト５５８で固定される上嵌合ブロック５５０とで構成される。また、下コネクタ３６ｂは、下ベース６００と下ベース６００の上面にボルト６５８で固定される下嵌合ブロック６５０とで構成されている。 Next, the detailed structure of the cleaning agent charging mechanism 30 will be described with reference to FIG. As shown in FIG. 3, the cleaning agent charging mechanism 30 includes an upper connector 36a, a lower connector 36b disposed coaxially with the upper connector 36a, a connector moving mechanism 560 that drives the connectors 36a and 36b in the vertical direction, An inlet pipe 32, an outlet pipe 33, a valve 34 disposed in the inlet pipe 32, and a valve 35 disposed in the outlet pipe 33 are included. The upper connector 36 a includes an upper base 500 and an upper fitting block 550 that is fixed to the lower surface of the upper base 500 with bolts 558. Further, the lower connector 36b includes a lower base 600 and a lower fitting block 650 that is fixed to the upper surface of the lower base 600 with bolts 658.
　上コネクタ３６ａの上ベース５００は、金属製の平板５０１と平板５０１の下面の中央から下向きに突出する上ノズル５０３とを含んでいる。平板５０１は、アーム５０６によってコネクタ移動機構５６０に接続されている。また、平板５０１の内部には、希釈液であるＲＯ水を導入する流通孔５０２が設けられている。流通孔５０２は平板５０１の側面まで延びて開口しており、この開口には入口管３２が接続されている。上ノズル５０３は、先端が尖った棒状で、中心部分には平板５０１の流通孔５０２に連通するように軸方向に延びる流通孔５０４が設けられている。また、上ノズル５０３の先端部分には、流通孔５０４と連通し、半径方向に延びて上ノズル５０３の外表面に開口する流通孔５０５が設けられている。 The upper base 500 of the upper connector 36a includes a metal flat plate 501 and an upper nozzle 503 protruding downward from the center of the lower surface of the flat plate 501. The flat plate 501 is connected to the connector moving mechanism 560 by an arm 506. In addition, a flow hole 502 for introducing RO water that is a diluent is provided inside the flat plate 501. The circulation hole 502 extends to the side surface of the flat plate 501 and opens, and the inlet pipe 32 is connected to the opening. The upper nozzle 503 has a rod shape with a sharp tip, and a flow hole 504 extending in the axial direction is provided in the center portion so as to communicate with the flow hole 502 of the flat plate 501. In addition, a flow hole 505 that communicates with the flow hole 504 and extends in the radial direction and opens to the outer surface of the upper nozzle 503 is provided at the tip portion of the upper nozzle 503.
　上コネクタ３６ａの上嵌合ブロック５５０は、上ベース５００の平板５０１にボルト５５８で固定されるフランジ５５１と、フランジ５５１の中央から下方向に延びる上本体５５０ａとを含んでいる。上本体５５０ａは円環状で中央に円形の二段穴が設けられている。上本体５５０ａの上ベース５００側には直径が上ノズル５０３の外径と同一のノズル取り付け穴５５３が設けられ、先端側には、図４に示すように洗浄剤容器３１の円環状の上首部３１ａが嵌合する上嵌合穴５５５が設けられている。上嵌合穴５５５の内径は上首部３１ａの外径と略同一径である。ノズル取り付け穴５５３の内面には上ノズル５０３の外面との間を水密にシールするためのパッキン５５４が取り付けられている。同様に、上嵌合穴５５５の内面にも洗浄剤容器３１の上首部３１ａとの間を水密にシールするためのパッキン５５６が設けられている。上嵌合穴５５５とパッキン５５６とは上嵌合部を構成する。また、上嵌合ブロック５５０の上ベース５００の平板５０１に接続される面にもパッキン５５２が設けられている。 The upper fitting block 550 of the upper connector 36a includes a flange 551 fixed to the flat plate 501 of the upper base 500 with a bolt 558, and an upper main body 550a extending downward from the center of the flange 551. The upper main body 550a has an annular shape and is provided with a circular two-stage hole in the center. A nozzle mounting hole 553 having the same diameter as the outer diameter of the upper nozzle 503 is provided on the upper base 500 side of the upper main body 550a, and an annular upper neck portion of the cleaning agent container 31 as shown in FIG. An upper fitting hole 555 for fitting 31a is provided. The inner diameter of the upper fitting hole 555 is substantially the same as the outer diameter of the upper neck portion 31a. A packing 554 is attached to the inner surface of the nozzle mounting hole 553 for watertight sealing with the outer surface of the upper nozzle 503. Similarly, a packing 556 is also provided on the inner surface of the upper fitting hole 555 for watertight sealing between the cleaning container 31 and the upper neck portion 31a. The upper fitting hole 555 and the packing 556 constitute an upper fitting portion. Further, a packing 552 is also provided on a surface connected to the flat plate 501 of the upper base 500 of the upper fitting block 550.
　下コネクタ３６ｂの下ベース６００は、金属製の平板６０１と平板６０１の上面の中央から上向きに突出する下ノズル６０３とを含んでいる。平板６０１は、アーム６０６によってコネクタ移動機構５６０に接続されている。下ノズル６０３は、円筒を斜めに切断したような形状で、尖った先端を備え、先端側には内径が大きい流通孔６０５が設けられ、下ベース６００側には流通孔６０５に連通するように軸方向に延びる流通孔６０４が設けられている。また、平板６０１の内部には下ノズル６０３の流通孔６０４に連通する流通孔６０２が設けられている。流通孔６０２は平板６０１の側面まで延びて開口しており、この開口には出口管３３が接続されている。図４に示すように上コネクタ３６ａと下コネクタ３６ｂとの間に取り付けられた洗浄剤容器３１に充填されていた洗浄・消毒剤及び、上コネクタ３６ａから洗浄剤容器３１の中に導入されたＲＯ水は、下ノズル６０３の流通孔６０５、６０４、下ベース６００の流通孔６０２を通って出口管３３から流出する。 The lower base 600 of the lower connector 36b includes a metal flat plate 601 and a lower nozzle 603 protruding upward from the center of the upper surface of the flat plate 601. The flat plate 601 is connected to the connector moving mechanism 560 by an arm 606. The lower nozzle 603 is shaped like a cylinder cut diagonally, has a sharp tip, a flow hole 605 having a large inner diameter is provided on the tip side, and communicates with the flow hole 605 on the lower base 600 side. A flow hole 604 extending in the axial direction is provided. A flow hole 602 that communicates with the flow hole 604 of the lower nozzle 603 is provided inside the flat plate 601. The circulation hole 602 extends to the side surface of the flat plate 601 and is opened, and the outlet pipe 33 is connected to the opening. As shown in FIG. 4, the cleaning / disinfecting agent filled in the cleaning agent container 31 attached between the upper connector 36a and the lower connector 36b, and the RO introduced into the cleaning agent container 31 from the upper connector 36a. Water flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 and the flow holes 602 of the lower base 600.
　下コネクタ３６ｂの下嵌合ブロック６５０は、上嵌合ブロック５５０と略同様の構成で、フランジ６５１と、フランジ６５１の中央から上方向に延びる下本体６５０ａとを含んでいる。下本体６５０ａは円環状で中央に円形の二段穴が設けられている。下本体６５０ａの下ベース６００側には直径が下ノズル６０３の外径と同一のノズル取り付け穴６５３が設けられ、先端側には、図４に示すように洗浄剤容器３１の円環状の下首部３１ｂが嵌合する下嵌合穴６５５が設けられている。下嵌合穴６５５の内径は下首部３１ｂの外径と略同一径である。ノズル取り付け穴６５３の内面には下ノズル６０３の外面との間を水密にシールするためのパッキン６５４が取り付けられている。同様に、下嵌合穴６５５の内面にも洗浄剤容器３１の下首部３１ｂとの間を水密にシールするためのパッキン６５６が設けられている。下嵌合穴６５５とパッキン６５６とは下嵌合部を構成する。また、下嵌合ブロック６５０の下ベース６００の平板６０１に接続される面にもパッキン６５２が設けられている。 The lower fitting block 650 of the lower connector 36b has substantially the same configuration as the upper fitting block 550, and includes a flange 651 and a lower main body 650a extending upward from the center of the flange 651. The lower main body 650a has an annular shape and is provided with a circular two-stage hole in the center. A nozzle mounting hole 653 having a diameter the same as the outer diameter of the lower nozzle 603 is provided on the lower base 600 side of the lower main body 650a, and an annular lower neck portion of the cleaning agent container 31 as shown in FIG. A lower fitting hole 655 for fitting 31b is provided. The inner diameter of the lower fitting hole 655 is substantially the same as the outer diameter of the lower neck portion 31b. A packing 654 is attached to the inner surface of the nozzle mounting hole 653 for watertight sealing with the outer surface of the lower nozzle 603. Similarly, a packing 656 is provided on the inner surface of the lower fitting hole 655 to seal the space between the lower neck portion 31b of the cleaning agent container 31 in a watertight manner. Lower fitting hole 655 and packing 656 constitute a lower fitting portion. A packing 652 is also provided on the surface of the lower base 600 that is connected to the flat plate 601 of the lower fitting block 650.
　図３に示すように、上コネクタ３６ａの上嵌合ブロック５５０の二段穴の中心、つまり、ノズル取り付け穴５５３と上嵌合穴５５５の中心と、下コネクタ３６ｂの下嵌合ブロック６５０の二段穴の中心、つまり、ノズル取り付け穴６５３と下嵌合穴６５５の中心とは、同一の中心線５８０の上に配置されている。従って、上下の各嵌合穴５５５、６５５は同軸に配置されている。また、本実施形態では、上ノズル５０３と下ノズル６０３の各中心も中心線５８０の上に配置されており、同軸配置となっている。 As shown in FIG. 3, the center of the two-step hole of the upper fitting block 550 of the upper connector 36a, that is, the center of the nozzle mounting hole 553 and the upper fitting hole 555, and the two of the lower fitting block 650 of the lower connector 36b. The center of the step hole, that is, the center of the nozzle mounting hole 653 and the lower fitting hole 655 is disposed on the same center line 580. Therefore, the upper and lower fitting holes 555 and 655 are arranged coaxially. In the present embodiment, the centers of the upper nozzle 503 and the lower nozzle 603 are also arranged on the center line 580 and are coaxially arranged.
　コネクタ移動機構５６０は、制御部９５に接続され、制御部９５の指令によって、或いは操作者の操作によって上コネクタ３６ａ、下コネクタ３６ｂのいずれか一方または両方を上下方向に移動させる。 The connector moving mechanism 560 is connected to the control unit 95, and moves either one or both of the upper connector 36a and the lower connector 36b in the vertical direction according to a command from the control unit 95 or an operation of the operator.
　薬剤投入機構６０は、先に説明した洗浄剤投入機構３０と同様の構造で、上コネクタ６６ａと、上コネクタ６６ａと同軸に配置される下コネクタ６６ｂと、各コネクタを上下方向に駆動するコネクタ移動機構５６０と、入口管６２と、出口管６３と入口管６２に配置された弁６４と出口管６３に配置された弁６５とを含んでいる。上コネクタ６６ａの上嵌合穴５５５と下コネクタ６６ｂの下嵌合穴６５５の各内径は、図２に示す薬剤容器６１の上首部６１ａ、下首部６１ｂの外径と略同一径となっている。 The medicine charging mechanism 60 has the same structure as the cleaning agent charging mechanism 30 described above, and includes an upper connector 66a, a lower connector 66b arranged coaxially with the upper connector 66a, and connector movement for driving each connector in the vertical direction. It includes a mechanism 560, an inlet pipe 62, an outlet pipe 63, a valve 64 disposed in the inlet pipe 62, and a valve 65 disposed in the outlet pipe 63. The inner diameters of the upper fitting hole 555 of the upper connector 66a and the lower fitting hole 655 of the lower connector 66b are substantially the same as the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the drug container 61 shown in FIG. .
　次に図４から図６を参照しながら洗浄剤容器３１を洗浄剤投入機構３０に取り付けて透析液供給装置１００の接液部の洗浄・消毒を行う方法について説明する。まず、図１に示す弁３４、３５、６４、６５を閉として洗浄剤容器３１を洗浄剤投入機構３０に取り付ける。また、カプラ８１、８２をダイアライザ９０の透析液入口９１、透析液出口９２から取り外し、接続カプラ９８で接続する。なお、接続カプラ９８を用いずに、カプラ８１とカプラ８２を直接接続してもよい。 Next, a method of cleaning and disinfecting the liquid contact portion of the dialysate supply apparatus 100 by attaching the cleaning agent container 31 to the cleaning agent charging mechanism 30 will be described with reference to FIGS. First, the cleaning agent container 31 is attached to the cleaning agent charging mechanism 30 with the valves 34, 35, 64, and 65 shown in FIG. Further, the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98. The coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.
　洗浄剤容器３１を洗浄剤投入機構３０の上コネクタ３６ａと下コネクタ３６ｂの間に取り付けるには、コネクタ移動機構５６０によって上コネクタ３６ａを上方向に、下コネクタ３６ｂを下方向に移動させ、上ノズル５０３の先端と下ノズル６０３の先端との間隔を洗浄剤容器３１の上下方向の全長さよりも長くした後、洗浄剤容器３１の上首部３１ａ、下首部３１ｂの各中心が中心線５８０の位置となるように洗浄剤容器３１を保持した状態で下コネクタ３６ｂを上方向に、上コネクタ３６ａを下方向に移動させる。すると、下コネクタ３６ｂは下ノズル６０３の尖った先端でシール部材３１ｄを破って洗浄剤容器３１の中に入り込み、下嵌合穴６５５は下首部３１ｂの外周に嵌り込む。そして、下嵌合穴６５５のパッキン６５６が下首部３１ｂの外周に密着する。同様に、上コネクタ３６ａは上ノズル５０３の尖った先端でシール部材３１ｃを破って洗浄剤容器３１の中に入り込み、上嵌合穴５５５は上首部３１ａの外周に嵌り込む。そして、上嵌合穴５５５のパッキン５５６が上首部３１ａの外周に密着する。これによって、図４に示すように、洗浄剤容器３１は、上コネクタ３６ａと下コネクタ３６ｂとの間に挟み込まれ、洗浄剤容器３１と、入口管３２と、出口管３３とは連通して１つの液体流路を形成する。 In order to attach the cleaning agent container 31 between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30, the upper connector 36a is moved upward and the lower connector 36b is moved downward by the connector moving mechanism 560. After the interval between the tip of 503 and the tip of the lower nozzle 603 is made longer than the overall length in the vertical direction of the cleaning agent container 31, the centers of the upper neck portion 31 a and the lower neck portion 31 b of the cleaning agent container 31 are positioned at the position of the center line 580. In the state where the cleaning agent container 31 is held, the lower connector 36b is moved upward and the upper connector 36a is moved downward. Then, the lower connector 36b breaks the seal member 31d at the sharp tip of the lower nozzle 603 and enters the cleaning agent container 31, and the lower fitting hole 655 fits into the outer periphery of the lower neck portion 31b. And the packing 656 of the lower fitting hole 655 adheres to the outer periphery of the lower neck part 31b. Similarly, the upper connector 36a breaks the seal member 31c at the sharp tip of the upper nozzle 503 and enters the cleaning agent container 31, and the upper fitting hole 555 fits into the outer periphery of the upper neck portion 31a. And the packing 556 of the upper fitting hole 555 adheres to the outer periphery of the upper neck part 31a. As a result, as shown in FIG. 4, the cleaning agent container 31 is sandwiched between the upper connector 36a and the lower connector 36b, and the cleaning agent container 31, the inlet pipe 32, and the outlet pipe 33 communicate with each other. One liquid flow path is formed.
　洗浄剤容器３１を上コネクタ３６ａと下コネクタ３６ｂとの間に取り付けたら、図５に示すように、入口管３２に配置されている弁３４と、出口管３３に配置されている弁３５を開とする。すると、図４の矢印に示すように、ＲＯ水が入口管３２から上コネクタ３６ａの平板５０１の流通孔５０２に流れ込んでくる。流通孔５０２に流れ込んだＲＯ水は、上ノズル５０３の流通孔５０４を通って上ノズル５０３の先端側の流通孔５０５から洗浄剤容器３１の中に流入する。洗浄剤容器３１の中に充填されている洗浄・消毒剤が粉末状態の場合には、洗浄剤容器３１の中で洗浄・消毒剤がＲＯ水中に溶解して濃度の高い洗浄・消毒液となり、下ノズル６０３の流通孔６０５、６０４から平板６０１の流通孔６０２を通って出口管３３から流出する。そして、図５の流路Ｒ１１に示すように、薬剤投入管１４を通ってタンク１５の中に流入する。水供給ポンプ１１は、タンク１５の中の洗浄・消毒液の濃度が所定の濃度になるまで、ＲＯ装置１２からＲＯ水をタンク１５に供給する。そしてタンク１５内の洗浄・消毒剤の濃度が所定の濃度に達したら、或いは、所定量のＲＯ水をタンク１５に供給したら、水供給ポンプ１１を停止する。 When the cleaning agent container 31 is attached between the upper connector 36a and the lower connector 36b, the valve 34 arranged in the inlet pipe 32 and the valve 35 arranged in the outlet pipe 33 are opened as shown in FIG. And Then, as shown by the arrow in FIG. 4, RO water flows from the inlet pipe 32 into the flow hole 502 of the flat plate 501 of the upper connector 36a. The RO water that has flowed into the flow hole 502 flows into the cleaning agent container 31 from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503. When the cleaning / disinfecting agent filled in the cleaning agent container 31 is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 31 to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 through the flow holes 602 of the flat plate 601. And it flows in into the tank 15 through the chemical | medical agent injection pipe | tube 14, as shown to flow path R11 of FIG. The water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
　次に、弁７７、１７９を閉として弁７９を開として、送液ポンプ７０を始動すると、タンク１５に貯留されている洗浄・消毒液は、図５に一点鎖線で示す流路Ｒ１２のように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→再循環管７８（弁７９）→ＲＯ水管１３→洗浄剤投入機構３０→薬剤投入管１４→タンク１５］と循環し、各機器及び配管の接液部を洗浄・消毒する。図５に示す流路Ｒ１２の洗浄・消毒を所定時間だけ行ったら流路Ｒ１２の洗浄・消毒を終了する。 Next, when the valves 77 and 179 are closed and the valve 79 is opened and the liquid feed pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R12 indicated by a one-dot chain line in FIG. [Tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → cleaner injection mechanism 30 → chemical supply Tube 14 → tank 15] is circulated, and the wetted parts of each device and pipe are cleaned and disinfected. When the cleaning and disinfection of the flow path R12 shown in FIG. 5 is performed for a predetermined time, the cleaning and disinfection of the flow path R12 is finished.
　流路Ｒ１２の洗浄・消毒が終了したら、図６に示すように、弁７９を閉として弁７７を開とする。すると、タンク１５に貯留されていた洗浄・消毒液は、図６の流路Ｒ１３に示すように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→弁７７→接続管７６→カプラ８１→接続カプラ９８→カプラ８２→透析液排出管８０］と流れ、ドレンから系外に排出される。タンク１５に貯留した洗浄・消毒液を流路Ｒ１３によって全てドレンから系外に排出したら、透析液供給装置１００の接液部の一次洗浄を終了する。 When the cleaning and disinfection of the flow path R12 is completed, the valve 79 is closed and the valve 77 is opened as shown in FIG. Then, the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate as shown in the flow path R13 of FIG. Supply pipe 73 → valve 77 → connection pipe 76 → coupler 81 → connection coupler 98 → coupler 82 → dialysate discharge pipe 80], and is discharged from the drain to the outside of the system. When all of the cleaning / disinfecting liquid stored in the tank 15 is discharged from the drain through the flow path R13, the primary cleaning of the liquid contact portion of the dialysate supply device 100 is finished.
　次に、先に洗浄剤投入機構３０に洗浄剤容器３１を取り付けたのと同様の手順で、もう一つの洗浄剤投入機構１３０に洗浄剤容器１３１を取り付け、水供給ポンプ１１によってＲＯ装置１２からタンク１５に所定量のＲＯ水を貯留し、洗浄剤投入機構１３０の弁１３４、１３５を開として送液ポンプ７０によってＲＯ水をタンク１５から洗浄剤容器１３１に導入し、洗浄・消毒液を流路Ｒ１４に示すように、［洗浄剤投入機構１３０→透析液排出管８０→再循環管１７８（弁１７９）→ＲＯ水管１３→洗浄剤投入機構３０→薬剤投入管１４→タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→弁７７→接続管７６→カプラ８１→接続カプラ９８→カプラ８２→洗浄剤投入機構１３０］と循環させて二次洗浄を行う。図６に示す流路Ｒ１４の洗浄・消毒を所定時間だけ行ったら二次洗浄を終了する。二次洗浄を終了したら、弁１７９を閉としてタンク１５に残っている洗浄・消毒液を流路Ｒ１３によってドレンから系外に排出する。 Next, the cleaning agent container 131 is attached to the other cleaning agent charging mechanism 130 in the same procedure as that for attaching the cleaning agent container 31 to the cleaning agent charging mechanism 30, and the water supply pump 11 removes the RO device 12 from the RO device 12. A predetermined amount of RO water is stored in the tank 15, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, and the RO water is introduced from the tank 15 into the cleaning agent container 131 by the liquid feeding pump 70, and the cleaning / disinfecting solution is allowed to flow. As shown in path R14, [detergent injection mechanism 130 → dialysate discharge pipe 80 → recirculation pipe 178 (valve 179) → RO water pipe 13 → cleaner injection mechanism 30 → drug injection pipe 14 → tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → valve 77 → connecting pipe 76 → coupler 81 → connecting coupler 98 → coupler 82 → cleaning agent charging mechanism 130] Performing secondary cleaning by circulating. When the flow path R14 shown in FIG. 6 is cleaned and disinfected for a predetermined time, the secondary cleaning ends. When the secondary cleaning is completed, the valve 179 is closed and the cleaning / disinfecting liquid remaining in the tank 15 is discharged from the drain to the outside through the flow path R13.
　その後、水供給ポンプ１１によってＲＯ水を系統中に流入させながら、図５に示す流路Ｒ１２或いは、図６に示す流路Ｒ１４を循環させ、タンク１５に所定量のＲＯ水が溜まったら、流路Ｒ１３によってタンク１５に溜まったＲＯ水をドレンから系外に排出するフラッシングを行って透析液供給装置１００の接液部の洗浄・消毒を終了する。なお、洗浄剤投入機構１３０、再循環管１７８、弁１７９がない場合には、一次洗浄のみを行うようにしてもよい。 Thereafter, the RO water is introduced into the system by the water supply pump 11 and circulated through the flow path R12 shown in FIG. 5 or the flow path R14 shown in FIG. Flushing for discharging the RO water accumulated in the tank 15 from the drain to the outside of the system by the path R13 is performed, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 100 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
　このように、本実施形態の透析液供給装置１００は、操作者が所定量の洗浄・消毒剤が充填・封止された洗浄剤容器３１を洗浄剤投入機構３０の上コネクタ３６ａと下コネクタ３６ｂとの間にセットするだけで透析液供給装置１００の接液部の洗浄・消毒を行うことができるので、操作者が洗浄・消毒剤に触れることなく容易に液流路の洗浄・消毒作業を行うことができる。また、洗浄・消毒剤が大気に触れることが無くなるので、洗浄・消毒剤のにおいの拡散を抑えることができる。 As described above, in the dialysate supply device 100 according to the present embodiment, the upper container 36a and the lower connector 36b of the cleaning agent charging mechanism 30 are provided with the cleaning agent container 31 filled and sealed by the operator with a predetermined amount of cleaning / disinfecting agent. The liquid contact part of the dialysate supply device 100 can be cleaned and disinfected by simply setting the gap between the liquid channel and the operator so that the liquid flow path can be easily cleaned and disinfected without touching the cleaning / disinfectant. It can be carried out. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
　なお、透析液供給装置１００によって透析液を透析装置９６に供給する場合には、洗浄剤容器３１を洗浄剤投入機構３０に取り付けるのと同様の方法で薬剤投入機構６０に薬剤容器６１を取り付け、ＲＯ水を薬剤容器６１に導入して薬剤を溶解して濃度の高い透析液とし、薬剤投入管１４からタンク１５の中に流入させる。そして、所定の濃度になるまでＲＯ水をタンク１５に流入させて所定濃度の透析液を生成し、タンク１５に貯留する。そして、タンク１５に貯留された所定濃度の透析液を送液ポンプ７０によって透析装置９６に供給する。 When the dialysate is supplied to the dialyzer 96 by the dialysate supply device 100, the drug container 61 is attached to the drug input mechanism 60 in the same manner as the cleaning agent container 31 is attached to the cleaning agent input mechanism 30. RO water is introduced into the drug container 61 to dissolve the drug to obtain a high-concentration dialysate, and flows into the tank 15 from the drug input tube 14. Then, RO water is caused to flow into the tank 15 until a predetermined concentration is reached, and a dialysate having a predetermined concentration is generated and stored in the tank 15. Then, the dialysate having a predetermined concentration stored in the tank 15 is supplied to the dialyzer 96 by the liquid feed pump 70.
　次に、図７から図９を参照しながら、他の実施形態の透析液供給装置２００について説明する。先に図１から図６を参照して説明した実施形態と同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply apparatus 200 according to another embodiment will be described with reference to FIGS. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted.
　図７に示す透析液供給装置２００は、図１から図６を参照して説明したようなタンク１５に所定濃度の透析液を生成、貯留し、貯留した透析液を透析装置９６に供給するバッチ式の透析液供給装置１００と異なり、ＲＯ水管１３の中に高濃度のＡ剤、Ｂ剤を少しずつ連続的に投入して所定濃度の透析液を生成し、透析装置９６に供給するものである。実施形態の透析液供給装置２００では、洗浄剤投入機構３０はＲＯ水管１３をバイパスするように配置されており、洗浄剤投入機構３０と平行するＲＯ水管１３には弁３７が配置されている。洗浄剤投入機構３０の構成は、先に図１から図６を参照して説明したものと同様である。なお、先に説明した実施形態と同様、本実施形態の透析液供給装置２００は、透析液排出管８０にもう一つの洗浄剤投入機構１３０備え、透析液排出管８０とＲＯ水管１３とを接続するもう一つの再循環管１７８と、弁１７９とを備えている。 The dialysate supply apparatus 200 shown in FIG. 7 generates and stores a predetermined concentration of dialysate in the tank 15 as described with reference to FIGS. 1 to 6, and supplies the stored dialysate to the dialyzer 96. Unlike the dialysate supply device 100 of the type, high concentration A agent and B agent are continuously added little by little into the RO water pipe 13 to generate a predetermined concentration of dialysate and supply it to the dialyzer 96. is there. In the dialysate supply device 200 of the embodiment, the cleaning agent charging mechanism 30 is disposed so as to bypass the RO water pipe 13, and a valve 37 is disposed in the RO water pipe 13 parallel to the cleaning agent charging mechanism 30. The configuration of the cleaning agent charging mechanism 30 is the same as that described above with reference to FIGS. As in the above-described embodiment, the dialysate supply apparatus 200 according to this embodiment includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13. Another recirculation pipe 178 and a valve 179 are provided.
　図７に示すように、薬剤投入機構５５は、Ｂ剤投入機構４０とＡ剤投入機構５０とを備えている。Ｂ剤投入機構４０は、Ｂ剤（粉末剤）が充填されたＢ剤容器４１の上下をコネクタ４９ａ、４９ｂに接続するものであり、入口管４２、出口管４３と入口管４２に配置された弁４５と出口管４３に配置されたＢ剤注入ポンプ４４、弁４６と、バイパス管４７と弁４８とを含む。コネクタ４９ａ、４９ｂの構造は、図３、図４を参照して説明したと同様の構造であるが、Ｂ剤容器４１のコネクタ４９ａ、４９ｂに設けられた流路（図３、図４に示す流通孔５０２または５０４、６０２または６０４）を閉とすることができる流路閉止機構が取り付けられている。Ｂ剤投入機構４０により高濃度のＢ剤をＲＯ水管１３に注入するには、弁４５、４６を開としてＢ剤容器４１の中に所定量のＲＯ水を導入してＢ剤容器４１の中に飽和濃度のＢ剤溶液を生成し、Ｂ剤注入ポンプ４４でＲＯ水管１３の中に少しずつ注入する。また、Ａ剤投入機構５０は、Ａ剤の高濃度の溶液が入ったＡ剤タンク５１と、Ａ剤注入ポンプ５３と、注入管５２と弁５４とを含んでおり、Ａ剤を注入する場合は、弁５４を開として、Ａ剤注入ポンプ５３によってＡ剤タンク５１からＡ剤の溶液を吸い上げてＲＯ水管１３の中に少しずつ注入する。Ｂ剤注入ポンプ４４の注入量、Ａ剤注入ポンプ５３の注入量は、各注入ポンプ４４、５３の下流側のＲＯ水管１３に取り付けられた電導度センサ（図示せず）で検出した電導度に基づいて制御部９５が調整する。ＲＯ水管１３の中に注入されたＡ剤、Ｂ剤の溶液は、図示しないミキシングチャンバでＲＯ水と混合されて所定の濃度の透析液となって透析装置９６に供給される。 As shown in FIG. 7, the drug charging mechanism 55 includes a B agent charging mechanism 40 and an A agent charging mechanism 50. The B agent charging mechanism 40 connects the upper and lower sides of the B agent container 41 filled with the B agent (powder agent) to the connectors 49a and 49b, and is disposed in the inlet pipe 42, the outlet pipe 43 and the inlet pipe 42. A B agent injection pump 44, a valve 46, a bypass pipe 47 and a valve 48 disposed in the valve 45 and the outlet pipe 43 are included. The structures of the connectors 49a and 49b are the same as those described with reference to FIGS. 3 and 4, but the flow paths provided in the connectors 49a and 49b of the B agent container 41 (shown in FIGS. 3 and 4). A flow path closing mechanism capable of closing the flow holes 502 or 504, 602 or 604) is attached. In order to inject a high-concentration B agent into the RO water pipe 13 by the B agent charging mechanism 40, the valves 45 and 46 are opened, and a predetermined amount of RO water is introduced into the B agent container 41. A B agent solution having a saturated concentration is generated in the RO water pipe 13 by a B agent injection pump 44 little by little. The agent A charging mechanism 50 includes an agent A tank 51 containing a high-concentration solution of agent A, an agent A injection pump 53, an injection pipe 52 and a valve 54, and injects agent A. Opens the valve 54, sucks up the solution of the agent A from the agent A tank 51 by the agent A injection pump 53 and injects it into the RO water pipe 13 little by little. The injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by a conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44, 53. The control unit 95 adjusts based on this. The solutions of agent A and agent B injected into the RO water pipe 13 are mixed with RO water in a mixing chamber (not shown) and supplied to the dialyzer 96 as a dialysate having a predetermined concentration.
　以上のように構成された透析液供給装置２００の接液部の洗浄を行う場合の方法について図８、図９を参照しながら説明する。 A method for cleaning the wetted part of the dialysate supply apparatus 200 configured as described above will be described with reference to FIGS.
　先に図４～図６を参照して説明したと同様の手順で洗浄剤容器３１を洗浄剤投入機構３０の上コネクタ３６ａと下コネクタ３６ｂの間に取り付ける。また、Ｂ剤投入機構４０のコネクタ４９ａ、４９ｂの流路閉止機構によって各コネクタ４９ａ、４９ｂの流路を閉止し、弁４８を開として洗浄・消毒液がバイパス管４７を通るようにする。そして、ＲＯ水管１３の弁３７、Ａ剤投入機構５０の弁５４、透析液供給管７３の弁７７を閉とし、再循環管７８の弁７９、洗浄剤投入機構３０の弁３４、３５を開とする。そして、ＲＯ装置１２から入口管３２を通して洗浄剤容器３１にＲＯ水を導入し、出口管３３から洗浄・消毒液をＲＯ水管１３に流入させる。そして、図８に示す流路Ｒ２２のように、送液ポンプ７０から再循環管７８、洗浄剤投入機構３０、Ｂ剤投入機構４０のバイパス管４７、送液ポンプ７０と洗浄・消毒液を循環させて一次洗浄を行う。 The cleaning agent container 31 is attached between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30 in the same procedure as described with reference to FIGS. Further, the flow path closing mechanism of the connectors 49a and 49b of the B agent charging mechanism 40 closes the flow paths of the connectors 49a and 49b, and the valve 48 is opened so that the cleaning / disinfecting liquid passes through the bypass pipe 47. Then, the valve 37 of the RO water pipe 13, the valve 54 of the agent A charging mechanism 50, the valve 77 of the dialysate supply pipe 73 are closed, and the valve 79 of the recirculation pipe 78 and the valves 34 and 35 of the cleaning agent charging mechanism 30 are opened. And Then, RO water is introduced from the RO device 12 into the cleaning agent container 31 through the inlet pipe 32, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 33. 8, the recirculation pipe 78, the cleaning agent charging mechanism 30, the bypass pipe 47 of the B agent charging mechanism 40, the liquid feeding pump 70, and the cleaning / disinfecting liquid are circulated from the liquid feeding pump 70. First cleaning is performed.
　一次洗浄が終わったら、図９に示す流路Ｒ２３によってＲＯ水を系統に注入しながら洗浄・消毒液をドレンから系外に排出する。そして、ＲＯ水をもう一つの洗浄剤投入機構１３０に導入して洗浄・消毒液を生成し、図９に示す流路Ｒ２４によって透析液排出管８０からＲＯ水管１３、洗浄剤投入機構３０、Ｂ剤投入機構４０、送液ポンプ７０に循環させて、接液部の二次洗浄を行う。二次洗浄を行った後、ＲＯ水を図８に示す流路Ｒ２２或いは図９に示す流路Ｒ２４に循環させた後、図９に示す流路Ｒ２３のようにドレンから系外に透析・洗浄液を排出して接液部のフラッシングを行い、洗浄・消毒作業を終了する。なお、洗浄剤投入機構１３０、再循環管１７８、弁１７９がない場合には、一次洗浄のみを行うようにしてもよい。 When the primary cleaning is completed, the cleaning / disinfecting liquid is discharged from the drain to the outside while injecting RO water into the system through the flow path R23 shown in FIG. Then, the RO water is introduced into another cleaning agent charging mechanism 130 to generate a cleaning / disinfecting solution, and the RO water pipe 13, the cleaning agent charging mechanism 30, B, and the like from the dialysate discharge pipe 80 by the flow path R24 shown in FIG. It is circulated through the agent charging mechanism 40 and the liquid feed pump 70 to perform secondary cleaning of the liquid contact portion. After the secondary cleaning, RO water is circulated through the flow path R22 shown in FIG. 8 or the flow path R24 shown in FIG. 9, and then the dialysis / cleaning solution is discharged from the drain to the outside as shown in the flow path R23 shown in FIG. The wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
　以上説明したように、本実施形態の透析液供給装置２００は、先に説明した透析液供給装置１００と同様、操作者が所定量の洗浄・消毒剤が充填・封止された洗浄剤容器３１を洗浄剤投入機構３０の上コネクタ３６ａと下コネクタ３６ｂとの間にセットするだけで接液部の洗浄・消毒を行うことができるので、操作者が洗浄・消毒剤に触れることなく容易に液流路の洗浄・消毒作業を行うことができる。また、洗浄・消毒剤が大気に触れることが無くなるので、洗浄・消毒剤のにおいの拡散を抑えることができる。 As described above, the dialysate supply apparatus 200 of the present embodiment is similar to the dialysate supply apparatus 100 described above, and the detergent container 31 is filled and sealed by the operator with a predetermined amount of cleaning / disinfectant. Can be cleaned and disinfected by simply setting between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30, so that the operator can easily touch the liquid without touching the cleaning / disinfectant. Cleaning and disinfection of the flow path can be performed. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
　次に、図１０から図１７を参照しながら、他の実施形態の透析液供給装置３００について説明する。先に図１から図６を参照して説明した実施形態と同様の部分には同様の符号を付して説明は省略する。図１０に示すように、本実施形態の透析液供給装置３００は、図１から図６を参照して説明したと同様、タンク１５に所定濃度の透析液を生成、貯留し、貯留した透析液を透析装置９６に供給するバッチ式の透析液供給装置であり、薬剤投入機構２０は薬剤容器（Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ）を取り付けて薬剤をタンク１５に投入することができると共に、洗浄剤容器２１Ｃ、２１Ｄを取り付けて洗浄・消毒液をタンク１５に投入することもできる。また、本実施形態の透析液供給装置３００には、先に説明した透析液供給装置１００、２００と同様、オプションとして図１６に破線で示すように、透析液排出管８０に、もう一つの洗浄剤投入機構１３０が配置され、透析液排出管８０とＲＯ水管１３とはもう一つの再循環管１７８によって接続されており、再循環管１７８には弁１７９が配置されている。 Next, a dialysate supply apparatus 300 according to another embodiment will be described with reference to FIGS. 10 to 17. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted. As shown in FIG. 10, the dialysate supply apparatus 300 of the present embodiment generates and stores a predetermined concentration of dialysate in the tank 15, as described with reference to FIGS. 1 to 6. Is a batch-type dialysate supply device that supplies the drug to the dialyzer 96, and the drug injection mechanism 20 is capable of supplying a drug to the tank 15 by attaching a drug container (A agent container 21A, B agent container 21B), The cleaning agent containers 21 </ b> C and 21 </ b> D may be attached to supply the cleaning / disinfecting liquid to the tank 15. Further, in the dialysate supply device 300 of the present embodiment, as in the dialysate supply devices 100 and 200 described above, as another option, as shown by a broken line in FIG. An agent charging mechanism 130 is arranged, the dialysate discharge pipe 80 and the RO water pipe 13 are connected by another recirculation pipe 178, and a valve 179 is arranged in the recirculation pipe 178.
　図１１に示すように、薬剤投入機構２０は、Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ、及び、洗浄剤容器２１Ｃ、２１Ｄを保持するストレージ部７２０と、ストレージ部７２０を回転させるモータ７０８と、上側の第１コネクタ２６ａと下側の第２コネクタ２６ｂと、各コネクタ２６ａ、２６ｂを上下方向に移動させるコネクタ移動機構５６０と、を含んでいる。 As shown in FIG. 11, the medicine injection mechanism 20 includes a storage unit 720 that holds the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D, a motor 708 that rotates the storage unit 720, and an upper side. The first connector 26a, the lower second connector 26b, and a connector moving mechanism 560 for moving the connectors 26a and 26b in the vertical direction.
　ストレージ部７２０は、図１２Ａ、図１２Ｂに示すような複数の穴７０１～７０４の開いた上円板７００と、下円板７１０とを接続シャフト７０７で一体に固定したものである。図１２Ａに示すように、上円板７００は、図１１に示すＡ剤容器２１Ａの本体２１Ａｅが入る複数の大きい丸穴７０１と、図１１に示すＢ剤容器２１Ｂの本体２１Ｂｅが入る複数の小さい丸穴７０２と、図１１に示す洗浄剤容器２１Ｃの本体２１Ｃｅが入る大きな四角穴７０３と、図１１に示す洗浄剤容器２１Ｄの本体２１Ｄｅが入る小さな四角穴７０４が開けられている。各穴７０１～７０４の内寸法は、各容器２１Ａ～２１Ｄの本体２１Ａｅ～２１Ｄｅの外形寸法と略同一である。また、下円板７１０には、上円板７００の各丸穴７０１、７０２、及び各四角穴７０３、７０４に対応する位置に、図１１に示す各容器２１Ａ～２１Ｄの各下首部２１Ａｂ～２１Ｄｂが入る複数の丸穴７１１が開けられている。丸穴７１１の直径は、各下首部２１Ａｂ～２１Ｄｂの外径よりも大きく、各本体２１Ａｅ～２１Ｄｅの外形寸法よりも小さいものであればよい。上円板７００と下円板７１０の中心はボス７０６で接続され、ボス７０６の中心にはシャフト７０５が取り付けられている。図１１に示すように、シャフト７０５は、モータ７０８のシャフト７０５に接続され、ストレージ部７２０は、モータ７０８によって回転するよう構成されている。図１１に示すように、第１コネクタ２６ａと第２コネクタ２６ｂはそれぞれアーム５０６、６０６によってコネクタ移動機構５６０に接続されている。また、図１４、図１５に示すように、第１コネクタ２６ａと第２コネクタ２６ｂとは中心が同じ中心線５８０の上に来るように配置されており、ストレージ部７２０の上円板７００に開けられた各穴７０１～７０４、下円板７１０に開けられた複数の丸穴７１１は、その中心が第１コネクタ２６ａ、第２コネクタ２６ｂの中心線５８０と交差する円周上に来るように配置されている。このため、ストレージ部７２０を回転させることにより、所定の容器２１Ａ～２１Ｄの中心軸を第１コネクタ２６ａと第２コネクタ２６ｂの中心線５８０と一致させることができる。また、ストレージ部７２０は、制御部９５に接続され、制御部９５の指令によって回転する。 The storage unit 720 is obtained by integrally fixing an upper disc 700 having a plurality of holes 701 to 704 and a lower disc 710 as shown in FIGS. 12A and 12B with a connection shaft 707. As shown in FIG. 12A, the upper disc 700 has a plurality of large round holes 701 for receiving the main body 21Ae of the agent A container 21A shown in FIG. 11 and a plurality of small holes for receiving the main bodies 21Be of the agent B container 21B shown in FIG. A round hole 702, a large square hole 703 for receiving the main body 21Ce of the cleaning agent container 21C shown in FIG. 11, and a small square hole 704 for receiving the main body 21De of the cleaning agent container 21D shown in FIG. The internal dimensions of the holes 701 to 704 are substantially the same as the external dimensions of the main bodies 21Ae to 21De of the containers 21A to 21D. In addition, the lower disk 710 has lower necks 21Ab to 21Db of the containers 21A to 21D shown in FIG. 11 at positions corresponding to the round holes 701 and 702 and the square holes 703 and 704 of the upper disk 700. A plurality of round holes 711 into which are inserted. The diameter of the round hole 711 may be larger than the outer diameter of the lower neck portions 21Ab to 21Db and smaller than the outer dimensions of the main bodies 21Ae to 21De. The center of the upper disc 700 and the lower disc 710 is connected by a boss 706, and a shaft 705 is attached to the center of the boss 706. As shown in FIG. 11, the shaft 705 is connected to the shaft 705 of the motor 708, and the storage unit 720 is configured to rotate by the motor 708. As shown in FIG. 11, the first connector 26a and the second connector 26b are connected to the connector moving mechanism 560 by arms 506 and 606, respectively. As shown in FIGS. 14 and 15, the first connector 26a and the second connector 26b are arranged so that their centers are on the same center line 580, and are opened in the upper disk 700 of the storage unit 720. The holes 701 to 704 and the plurality of round holes 711 formed in the lower disk 710 are arranged so that their centers are on the circumference intersecting the center line 580 of the first connector 26a and the second connector 26b. Has been. Therefore, by rotating the storage unit 720, the center axes of the predetermined containers 21A to 21D can be aligned with the center lines 580 of the first connector 26a and the second connector 26b. The storage unit 720 is connected to the control unit 95 and rotates according to a command from the control unit 95.
　第１コネクタ２６ａと第２コネクタ２６ｂの各ベース５００、６００は、先に図３を参照して説明した上コネクタ３６ａ、下コネクタ３６ｂの各ベース５００、６００と同様の構成であるが、上側の第１嵌合ブロック５１０、下側の第２嵌合ブロック６１０は、図３を参照して説明した上嵌合ブロック５５０、下嵌合ブロック６５０と異なり、第１本体５１０ａ、第２本体６１０ａに円環状の三段穴が設けられたものである。 The bases 500 and 600 of the first connector 26a and the second connector 26b have the same structure as the bases 500 and 600 of the upper connector 36a and the lower connector 36b described above with reference to FIG. The first fitting block 510 and the lower second fitting block 610 are different from the upper fitting block 550 and the lower fitting block 650 described with reference to FIG. 3 in the first main body 510a and the second main body 610a. An annular three-stage hole is provided.
　図１３に示すように、第１本体５１０ａは円環状で中央に円形の三段穴が設けられている。第１本体５１０ａの上ベース５００側にはノズル取り付け穴５１３が設けられ、先端側には、図１５に示すように洗浄剤容器２１Ｃの円環状の上首部２１Ｃａの外周が嵌合する第２嵌合穴５１７が設けられており、ノズル取り付け穴５１３と第２嵌合穴５１７との間には、図１４に示すように、Ｂ剤容器２１Ｂの上首部２１Ｂａの外周が嵌合する第１嵌合穴５１５が設けられている。第２嵌合穴５１７の内径は、第１嵌合穴５１５の内径よりも大きくなっている。第１嵌合穴５１５の内径、第２嵌合穴５１７の内径は、それぞれＢ剤容器２１Ｂの上首部２１Ｂａ、洗浄剤容器２１Ｃの上首部２１Ｃａの外径と略同一径である。ノズル取り付け穴５１３の内面には、上ノズル５０３の外面との間を水密にシールするためのパッキン５１４が取り付けられ、第１嵌合穴５１５の内面には、Ｂ剤容器２１Ｂの上首部２１Ｂａの外周面との間を水密にシールするためのパッキン５１６が取り付けられ、第２嵌合穴５１７の内面には、洗浄剤容器２１Ｃの上首部２１Ｃａの外周面との間を水密にシールするためのパッキン５１８が取り付けられている。第１嵌合穴５１５とパッキン５１６とは第１嵌合部を構成し、第２嵌合穴５１７とパッキン５１８とは第２嵌合部を構成する。また、洗浄剤容器２１Ｃの円環状の上首部２１Ｃａとのその外周は、それぞれ第２首部と第２外周を構成し、Ｂ剤容器２１Ｂの上首部２１Ｂａとその外周は、それぞれ第１首部と第１外周を構成する。 As shown in FIG. 13, the first main body 510a has an annular shape and is provided with a circular three-stage hole in the center. A nozzle mounting hole 513 is provided on the upper base 500 side of the first main body 510a, and a second fitting into which the outer periphery of the annular upper neck portion 21Ca of the cleaning agent container 21C is fitted, as shown in FIG. As shown in FIG. 14, the first fitting in which the outer periphery of the upper neck portion 21Ba of the B agent container 21B is fitted between the nozzle mounting hole 513 and the second fitting hole 517. A joint hole 515 is provided. The inner diameter of the second fitting hole 517 is larger than the inner diameter of the first fitting hole 515. The inner diameter of the first fitting hole 515 and the inner diameter of the second fitting hole 517 are substantially the same as the outer diameter of the upper neck portion 21Ba of the B agent container 21B and the upper neck portion 21Ca of the cleaning agent container 21C, respectively. A packing 514 for watertightly sealing the outer surface of the upper nozzle 503 is attached to the inner surface of the nozzle mounting hole 513, and the upper neck portion 21Ba of the B agent container 21B is attached to the inner surface of the first fitting hole 515. A packing 516 is provided for watertight sealing between the outer peripheral surface and the inner surface of the second fitting hole 517 for watertight sealing between the outer peripheral surface of the upper neck portion 21Ca of the cleaning agent container 21C. A packing 518 is attached. The first fitting hole 515 and the packing 516 constitute a first fitting portion, and the second fitting hole 517 and the packing 518 constitute a second fitting portion. Further, the outer periphery of the cleaning agent container 21C with the annular upper neck portion 21Ca constitutes the second neck portion and the second outer periphery, respectively, and the upper neck portion 21Ba of the B agent container 21B and the outer periphery thereof are respectively connected with the first neck portion and the second outer periphery. 1 circumference is comprised.
　図１３に示すように、第２本体６１０ａも第１本体５１０ａと同様、円環状で中央に円形の三段穴が設けられている。第２本体６１０ａの下ベース６００側にはノズル取り付け穴６１３が設けられ、先端側には、図１５に示すように洗浄剤容器２１Ｃの円環状の下首部２１Ｃｂの外周が嵌合する第４嵌合穴６１７が設けられており、ノズル取り付け穴６１３と第４嵌合穴６１７との間には、図１４に示すように、Ｂ剤容器２１Ｂの下首部２１Ｂｂの外周が嵌合する第３嵌合穴６１５が設けられている。第４嵌合穴６１７の内径は、第３嵌合穴６１５の内径よりも大きくなっている。第３嵌合穴６１５の内径、第４嵌合穴６１７の内径は、それぞれＢ剤容器２１Ｂの下首部２１Ｂｂ、洗浄剤容器２１Ｃの下首部２１Ｃｂの外径と略同一径である。ノズル取り付け穴６１３の内面には、下ノズル６０３の外周面との間を水密にシールするためのパッキン６１４が取り付けられ、第３嵌合穴６１５の内面には、Ｂ剤容器２１Ｂの下首部２１Ｂｂの外周面との間を水密にシールするためのパッキン６１６が取り付けられ、第４嵌合穴６１７の内面には、洗浄剤容器２１Ｃの下首部２１Ｃｂの外面との間を水密にシールするためのパッキン６１８が取り付けられている。第３嵌合穴６１５とパッキン６１６とは第３嵌合部を構成し、第４嵌合穴６１７とパッキン６１８とは第４嵌合部を構成する。また、洗浄剤容器２１Ｃの円環状の下首部２１Ｃｂとその外周とは、それぞれ第４首部と第４外周を構成し、Ｂ剤容器２１Ｂの下首部２１Ｂｂとその外周とは、それぞれ第３首部と第３外周を構成する。 As shown in FIG. 13, the second main body 610a has an annular shape and a circular three-stage hole at the center, similarly to the first main body 510a. A nozzle mounting hole 613 is provided on the lower base 600 side of the second main body 610a, and a fourth fitting into which the outer periphery of the annular lower neck portion 21Cb of the cleaning agent container 21C is fitted, as shown in FIG. A joint hole 617 is provided, and a third fitting in which the outer periphery of the lower neck portion 21Bb of the B agent container 21B is fitted between the nozzle mounting hole 613 and the fourth fitting hole 617 as shown in FIG. A joint hole 615 is provided. The inner diameter of the fourth fitting hole 617 is larger than the inner diameter of the third fitting hole 615. The inner diameter of the third fitting hole 615 and the inner diameter of the fourth fitting hole 617 are approximately the same diameter as the outer diameter of the lower neck portion 21Bb of the B agent container 21B and the lower neck portion 21Cb of the cleaning agent container 21C, respectively. A packing 614 for watertight sealing with the outer peripheral surface of the lower nozzle 603 is attached to the inner surface of the nozzle attachment hole 613, and the lower neck portion 21Bb of the B agent container 21B is attached to the inner surface of the third fitting hole 615. A packing 616 for watertight sealing between the outer peripheral surface of the cleaning container 21C and the outer surface of the lower neck portion 21Cb of the cleaning agent container 21C is sealed on the inner surface of the fourth fitting hole 617. A packing 618 is attached. The third fitting hole 615 and the packing 616 constitute a third fitting portion, and the fourth fitting hole 617 and the packing 618 constitute a fourth fitting portion. Further, the annular lower neck portion 21Cb of the cleaning agent container 21C and the outer periphery thereof constitute a fourth neck portion and a fourth outer periphery, respectively, and the lower neck portion 21Bb of the B agent container 21B and the outer periphery thereof are respectively connected to the third neck portion. A third outer periphery is formed.
　上記の説明では、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃを例に説明したが、Ａ剤容器２１Ａの上首部２１Ａａ、下首部２１Ａｂ、洗浄剤容器２１Ｄの上首部２１Ｄａ、下首部２１Ｄｂの外径は、それぞれ、Ｂ剤容器２１Ｂの上首部２１Ｂａ、下首部２１Ｂｂ、洗浄剤容器２１Ｃの上首部２１Ｃａ、下首部２１Ｃｂの外径と同一であり、Ａ剤容器２１Ａの上首部２１Ａａ、下首部２１Ａｂはそれぞれ第１、第３嵌合穴５１５、６１５に嵌まり込み、洗浄剤容器２１Ｄの上首部２１Ｄａ、下首部２１Ｄｂはそれぞれ第２、第４嵌合穴５１７、６１７に嵌まり込む。なお、Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄは、ストレージ部７２０に保持可能な容器２１である。 In the above description, the B agent container 21B and the cleaning agent container 21C have been described as examples. However, the outer diameters of the upper neck portion 21Aa, the lower neck portion 21Ab, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are as follows. The upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B are the same as the outer diameters of the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C. The upper neck portion 21Aa and the lower neck portion 21Ab of the A agent container 21A are respectively the same. The first and third fitting holes 515 and 615 are fitted, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are fitted into the second and fourth fitting holes 517 and 617, respectively. The agent A container 21A, the agent B container 21B, and the detergent containers 21C and 21D are containers 21 that can be held in the storage unit 720.
　図１４に示すように、Ｂ剤容器２１Ｂを薬剤投入機構２０の第１コネクタ２６ａと第２コネクタ２６ｂの間に取り付けるには、まず、ストレージ部７２０の穴７０１～７０４にＡ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、洗浄剤容器２１Ｄをそれぞれセットしておく。そして、図１０に示す弁２４、２５を閉とした後、コネクタ移動機構５６０によって第１コネクタ２６ａを上方向に、第２コネクタ２６ｂを下方向に移動させ、上ノズル５０３の先端と下ノズル６０３の先端との間隔をＢ剤容器２１Ｂの上下方向の全長さよりも長くする。その後、図１１に示すモータ７０８によってストレージ部７２０を回転させて、図１４に示すように、Ｂ剤容器２１Ｂの中心を第１、第２コネクタ２６ａ、２６ｂの中心線５８０と同一位置とし、コネクタ移動機構５６０によって第２コネクタ２６ｂを上方向に、第１コネクタ２６ａを下方向にそれぞれ移動させる。すると、第２コネクタ２６ｂは下ノズル６０３の尖った先端でシール部材２１Ｂｄを破ってＢ剤容器２１Ｂの中に入り込み、第３嵌合穴６１５は下首部２１Ｂｂの外周に嵌り込む。そして、第３嵌合穴６１５のパッキン６１６が下首部２１Ｂｂの外周に密着する。同様に、第１コネクタ２６ａは上ノズル５０３の尖った先端でシール部材２１Ｂｃを破ってＢ剤容器２１Ｂの中に入り込み、第１嵌合穴５１５は上首部２１Ｂａの外周に嵌り込む。そして、第１嵌合穴５１５のパッキン５１６が上首部２１Ｂａの外周に密着する。これによって、図１４に示すように、Ｂ剤容器２１Ｂは、第１コネクタ２６ａと第２コネクタ２６ｂとの間に挟み込まれ、Ｂ剤容器２１Ｂと、入口管２２と、出口管２３とは連通して１つの液体流路を形成する。 As shown in FIG. 14, in order to attach the B agent container 21B between the first connector 26a and the second connector 26b of the medicine injection mechanism 20, first, the A agent containers 21A, B are inserted into the holes 701 to 704 of the storage unit 720. The agent container 21B, the detergent container 21C, and the detergent container 21D are set in advance. Then, after closing the valves 24 and 25 shown in FIG. 10, the first connector 26 a is moved upward and the second connector 26 b is moved downward by the connector moving mechanism 560, and the tip of the upper nozzle 503 and the lower nozzle 603 are moved. Is made longer than the overall length of the B agent container 21B in the vertical direction. Thereafter, the storage unit 720 is rotated by the motor 708 shown in FIG. 11, and the center of the B agent container 21B is set at the same position as the center line 580 of the first and second connectors 26a and 26b as shown in FIG. The moving mechanism 560 moves the second connector 26b upward and the first connector 26a downward. Then, the second connector 26b breaks the seal member 21Bd at the sharp tip of the lower nozzle 603 and enters the B agent container 21B, and the third fitting hole 615 fits into the outer periphery of the lower neck portion 21Bb. And the packing 616 of the 3rd fitting hole 615 closely_contact | adheres to the outer periphery of lower neck part 21Bb. Similarly, the first connector 26a breaks the seal member 21Bc at the sharp tip of the upper nozzle 503 and enters the B agent container 21B, and the first fitting hole 515 fits into the outer periphery of the upper neck portion 21Ba. And the packing 516 of the 1st fitting hole 515 closely_contact | adheres to the outer periphery of upper neck part 21Ba. As a result, as shown in FIG. 14, the B agent container 21B is sandwiched between the first connector 26a and the second connector 26b, and the B agent container 21B, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.
　この状態で、弁２４、２５を開として、ＲＯ水をＢ剤容器２１Ｂに導入してＢ剤を溶解して濃度の高い溶液とし、薬剤投入管１４からタンク１５の中に流入させる。投入が終了したら、第１コネクタ２６ａ、第２コネクタ２６ｂを上下方向に開くように移動させて、上ノズル５０３の先端と下ノズル６０３の先端との間隔をＢ剤容器２１Ｂの上下方向の全長さよりも長くした後、Ａ剤容器２１Ａの中心が第１、第２コネクタ２６ａ、２６ｂの中心線５８０と同一位置となるように、ストレージ部７２０を回転させ、コネクタ移動機構５６０を動作させてＡ剤容器２１Ａを第１、第２コネクタ２６ａ、２６ｂの間に取り付ける。そして、ＲＯ水をＡ剤容器２１Ａに導入してＡ剤を溶解して濃度の高い溶液とし、薬剤投入管１４からタンク１５の中に流入させる。そして、所定の濃度になるまでタンク１５の中にＲＯ水を流入させて所定濃度の透析液を生成し、送液ポンプ７０でタンク１５の中の透析液を透析装置９６に供給する。 In this state, the valves 24 and 25 are opened, and RO water is introduced into the B agent container 21B to dissolve the B agent into a high-concentration solution and flow into the tank 15 from the drug introduction tube 14. When the charging is completed, the first connector 26a and the second connector 26b are moved so as to open in the vertical direction, and the distance between the tip of the upper nozzle 503 and the tip of the lower nozzle 603 is larger than the total length in the vertical direction of the B agent container 21B. After that, the storage unit 720 is rotated so that the center of the agent A container 21A is located at the same position as the center line 580 of the first and second connectors 26a and 26b, and the connector moving mechanism 560 is operated to operate the agent A. The container 21A is attached between the first and second connectors 26a and 26b. And RO water is introduce | transduced into the A agent container 21A, A agent is melt | dissolved to make a high concentration solution, and it flows in into the tank 15 from the chemical | medical agent injection pipe 14. Then, RO water is allowed to flow into the tank 15 until a predetermined concentration is reached to generate a dialysate having a predetermined concentration, and the dialysate in the tank 15 is supplied to the dialyzer 96 by the liquid feed pump 70.
　次に図１５から図１７を参照しながら洗浄剤容器２１Ｃを薬剤投入機構２０に取り付けて透析液供給装置２００の接液部の洗浄・消毒を行う方法について説明する。まず、図１０に示す弁２４、２５を閉として洗浄剤容器２１Ｃを薬剤投入機構２０に取り付ける。また、カプラ８１、８２をダイアライザ９０の透析液入口９１、透析液出口９２から取り外し、接続カプラ９８で接続する。なお、接続カプラ９８を用いずに、カプラ８１とカプラ８２を直接接続してもよい。 Next, a method for cleaning and disinfecting the liquid contact portion of the dialysate supply apparatus 200 by attaching the cleaning agent container 21C to the medicine charging mechanism 20 will be described with reference to FIGS. First, the valves 24 and 25 shown in FIG. 10 are closed, and the cleaning agent container 21 </ b> C is attached to the medicine charging mechanism 20. Further, the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98. The coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.
　洗浄剤容器２１Ｃを薬剤投入機構２０に取り付ける工程は、先に説明したＢ剤容器２１Ｂを薬剤投入機構２０に取り付ける工程と同様であるが、図１５に示すように、第２コネクタ２６ｂの第４嵌合穴６１７が洗浄剤容器２１Ｃの下首部２１Ｃｂの外周に嵌り込み、第４嵌合穴６１７のパッキン６１８が下首部２１Ｃｂの外周に密着する。同様に、第１コネクタ２６ａの第２嵌合穴５１７は上首部２１Ｃａの外周に嵌り込む。そして、第２嵌合穴５１７のパッキン５１８が上首部２１Ｃａの外周に密着する。これによって、図１５に示すように、洗浄剤容器２１Ｃは、第１コネクタ２６ａと第２コネクタ２６ｂとの間に挟み込まれ、洗浄剤容器２１Ｃと、入口管２２と、出口管２３とは連通して１つの液体流路を形成する。 The process of attaching the cleaning agent container 21C to the medicine injection mechanism 20 is the same as the process of attaching the B agent container 21B described above to the medicine injection mechanism 20, but as shown in FIG. 15, the fourth of the second connector 26b. The fitting hole 617 is fitted into the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C, and the packing 618 of the fourth fitting hole 617 is in close contact with the outer periphery of the lower neck portion 21Cb. Similarly, the second fitting hole 517 of the first connector 26a is fitted into the outer periphery of the upper neck portion 21Ca. And the packing 518 of the 2nd fitting hole 517 closely_contact | adheres to the outer periphery of upper neck part 21Ca. As a result, as shown in FIG. 15, the cleaning agent container 21C is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.
　図１５に示すように、洗浄剤容器２１Ｃの上首部２１Ｃａと下首部２１Ｃｂとをそれぞれ第１、第２コネクタ２６ａ、２６ｂの第２、第４嵌合穴５１７、６１７にはめ込んだ状態では、先に図１４を参照して説明したＢ剤容器２１Ｂの上首部２１Ｂａと下首部２１Ｂｂとが嵌り込んでいた第１、第３嵌合穴５１５、６１５の内面と、上ノズル５０３、下ノズル６０３の各外面との間には空間ができる。このため、Ｂ剤容器２１Ｂが薬剤投入機構２０に取り付けられた際に上首部２１Ｂａ、下首部２１Ｂｂの外面が接触していた第１、第３嵌合穴５１５、６１５の内面にも洗浄液が通流することができ、各嵌合穴５１５、６１５の内側の接触面に残留したＢ剤或いはＡ剤を洗浄することができる。 As shown in FIG. 15, when the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C are fitted in the second and fourth fitting holes 517 and 617 of the first and second connectors 26a and 26b, respectively, 14 with reference to FIG. 14, the inner surfaces of the first and third fitting holes 515 and 615 in which the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B are fitted, and the upper nozzle 503 and the lower nozzle 603 There is a space between each outer surface. For this reason, the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 that are in contact with the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb when the B agent container 21B is attached to the medicine injection mechanism 20. The B agent or the A agent remaining on the contact surface inside each fitting hole 515, 615 can be washed.
　図１５に示すように、洗浄剤容器２１Ｃを第１コネクタ２６ａと第２コネクタ２６ｂとの間に取り付けたら、図１６に示すように、入口管２２に配置されている弁２４と、出口管２３に配置されている弁２５を開とすると、図１６に示すように、ＲＯ水が入口管２２から第１コネクタ２６ａの平板５０１の流通孔５０２に流れ込んでくる。流通孔５０２に流れ込んだＲＯ水は、図１５に示すように、上ノズル５０３の流通孔５０４を通って上ノズル５０３の先端側の流通孔５０５から洗浄剤容器２１Ｃに流入する。洗浄剤容器２１Ｃの中に充填されている洗浄・消毒剤が粉末状態の場合には、洗浄剤容器２１Ｃの中で洗浄・消毒剤がＲＯ水中に溶解して濃度の高い洗浄・消毒液となり、下ノズル６０３の流通孔６０５、６０４から平板６０１の流通孔６０２を通って出口管２３から流出する。そして、図１６の流路Ｒ３１に示すように、薬剤投入管１４を通ってタンク１５の中に流入する。水供給ポンプ１１は、タンク１５の中の洗浄・消毒液の濃度が所定の濃度になるまで、ＲＯ装置１２からＲＯ水をタンク１５に供給する。そしてタンク１５内の洗浄・消毒剤の濃度が所定の濃度に達したら、或いは、所定量のＲＯ水をタンク１５に供給したら、水供給ポンプ１１を停止する。 As shown in FIG. 15, when the cleaning agent container 21C is attached between the first connector 26a and the second connector 26b, as shown in FIG. 16, the valve 24 disposed in the inlet pipe 22 and the outlet pipe 23 When the valve 25 arranged at is opened, RO water flows from the inlet pipe 22 into the flow hole 502 of the flat plate 501 of the first connector 26a, as shown in FIG. As shown in FIG. 15, the RO water that has flowed into the flow hole 502 flows into the cleaning agent container 21 </ b> C from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503. When the cleaning / disinfecting agent filled in the cleaning agent container 21C is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 21C to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 23 through the flow holes 605 and 604 of the lower nozzle 603, through the flow holes 602 of the flat plate 601. Then, as shown in a flow path R31 of FIG. The water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
　次に、弁７７、１７９を閉として弁７９を開として、送液ポンプ７０を始動すると、タンク１５に貯留されている洗浄・消毒液は、図１６に一点鎖線で示す流路Ｒ３２のように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→再循環管７８（弁７９）→ＲＯ水管１３→薬剤投入機構２０→薬剤投入管１４→タンク１５］と循環し、各機器及び配管の接液部を洗浄・消毒する。その際、図１５に示すように、洗浄・消毒液は、第３嵌合穴６１５の内面と下ノズル６０３の外面との間の空間６２０に流れ込んで、第３嵌合穴６１５の内面の洗浄・消毒を行う。図１６に示す流路Ｒ３２の洗浄・消毒を所定時間だけ行ったら流路Ｒ３２の洗浄・消毒を終了する。 Next, when the valves 77 and 179 are closed and the valve 79 is opened and the liquid feed pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R32 indicated by a one-dot chain line in FIG. [Tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → drug injection mechanism 20 → drug injection pipe 14 → Tank 15] to circulate and clean and disinfect the wetted parts of each device and piping. At that time, as shown in FIG. 15, the cleaning / disinfecting liquid flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603 to clean the inner surface of the third fitting hole 615.・ Disinfect. When the cleaning / disinfection of the flow path R32 shown in FIG. 16 is performed for a predetermined time, the cleaning / disinfection of the flow path R32 is terminated.
　流路Ｒ３２の洗浄・消毒が終了したら、図１７に示すように、弁７９を閉として弁７７を開とする。すると、タンク１５に貯留されていた洗浄・消毒液は、図１７の流路Ｒ３３に示すように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→弁７７→接続管７６→カプラ８１→接続カプラ９８→カプラ８２→透析液排出管８０］と流れ、ドレンから系外に排出される。タンク１５に貯留した洗浄・消毒液を流路Ｒ３３によって全てドレンから系外に排出したら、透析液供給装置３００の接液部の一次洗浄を終了する。 When the cleaning and disinfection of the flow path R32 is completed, the valve 79 is closed and the valve 77 is opened as shown in FIG. Then, as shown in the flow path R33 in FIG. 17, the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate. Supply pipe 73 → valve 77 → connection pipe 76 → coupler 81 → connection coupler 98 → coupler 82 → dialysate discharge pipe 80], and is discharged from the drain to the outside of the system. When all of the cleaning / disinfecting solution stored in the tank 15 is discharged from the drain through the flow path R33, the primary cleaning of the liquid contact portion of the dialysate supply device 300 is finished.
　次に、先に図１から図６を参照して説明したと同様の手順で、もう一つの洗浄剤投入機構１３０に洗浄剤容器１３１を取り付け、水供給ポンプ１１によってＲＯ装置１２からタンク１５に所定量のＲＯ水を貯留し、洗浄剤投入機構１３０の弁１３４、１３５を開として送液ポンプ７０によってＲＯ水をタンク１５から洗浄剤容器１３１に導入し、洗浄・消毒液を流路Ｒ３４に示すように、［洗浄剤投入機構１３０→透析液排出管８０→再循環管１７８（弁１７９）→ＲＯ水管１３→洗浄剤投入機構３０→薬剤投入管１４→タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→弁７７→接続管７６→カプラ８１→接続カプラ９８→カプラ８２→洗浄剤投入機構１３０］と循環させて二次洗浄を行う。図１７に示す流路Ｒ３４の洗浄・消毒を所定時間だけ行ったら二次洗浄を終了する。二次洗浄を終了したら、弁１７９を閉としてタンク１５に残っている洗浄・消毒液を流路Ｒ３３によってドレンから系外に排出する。 Next, in the same procedure as described above with reference to FIGS. 1 to 6, the cleaning agent container 131 is attached to another cleaning agent charging mechanism 130, and the RO device 12 is transferred from the RO device 12 to the tank 15 by the water supply pump 11. A predetermined amount of RO water is stored, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, the RO pump 70 introduces the RO water from the tank 15 into the cleaning agent container 131, and the cleaning / disinfecting solution flows into the flow path R34. As shown, [detergent input mechanism 130 → dialysate discharge pipe 80 → recirculation pipe 178 (valve 179) → RO water pipe 13 → cleaner input mechanism 30 → drug input pipe 14 → tank 15 → pump suction pipe 16 → feed Secondary washing by circulating the fluid pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → valve 77 → connecting pipe 76 → coupler 81 → connecting coupler 98 → coupler 82 → cleaning agent introduction mechanism 130] It is carried out. When the channel R34 shown in FIG. 17 is cleaned and disinfected for a predetermined time, the secondary cleaning is finished. When the secondary cleaning is completed, the valve 179 is closed and the cleaning / disinfecting liquid remaining in the tank 15 is discharged from the drain to the outside through the flow path R33.
　その後、水供給ポンプ１１によってＲＯ水を系統中に流入させながら、図１６に示す流路Ｒ３２或いは、図１７に示す流路Ｒ３４を循環させ、タンク１５に所定量のＲＯ水が溜まったら、図１７に示す流路Ｒ３３によってタンク１５に溜まったＲＯ水をドレンから系外に排出するフラッシングを行って透析液供給装置３００の接液部の洗浄・消毒を終了する。なお、洗浄剤投入機構１３０、再循環管１７８、弁１７９がない場合には、一次洗浄のみを行うようにしてもよい。 Thereafter, the RO water is caused to flow into the system by the water supply pump 11 while circulating the flow path R32 shown in FIG. 16 or the flow path R34 shown in FIG. Flushing is performed to discharge the RO water accumulated in the tank 15 from the drain to the outside of the system by the flow path R33 shown in FIG. 17, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 300 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
　このように、本実施形態の透析液供給装置３００は、操作者が所定量の洗浄・消毒剤が充填・封止された洗浄剤容器２１Ｃ或いは２１Ｄを薬剤投入機構２０のストレージ部７２０の穴７０３、７０４にセットするだけで、透析液供給装置３００の接液部の洗浄・消毒を行うことができるので、操作者が洗浄・消毒剤に触れることなく容易に液流路の洗浄・消毒作業を行うことができる。また、本実施形態の透析液供給装置３００は、１つの薬剤投入機構２０によってＡ剤、Ｂ剤、二種類の洗浄・消毒剤をそれぞれ配管或いはタンク１５に投入することができるので、簡便な構成とすることができる。また、薬剤、或いは洗浄剤の投入に際しては、ストレージ部７２０の回転、位置決め、第１、第２コネクタ２６ａ、２６ｂによる容器２１の挟み込み、取り外し等の一連の工程を制御部９５の指令によって一括制御できるので、自動化を図れると共に、操作者が洗浄・消毒剤に触れることなく容易に液流路の洗浄・消毒作業を行うことができる。また、洗浄・消毒剤が大気に触れることが無くなるので、洗浄・消毒剤のにおいの拡散を抑えることができる。 As described above, in the dialysate supply device 300 according to the present embodiment, the operator puts the cleaning agent container 21C or 21D filled and sealed with a predetermined amount of the cleaning / disinfecting agent into the hole 703 of the storage unit 720 of the medicine charging mechanism 20. 704, the fluid contact part of the dialysate supply device 300 can be cleaned and disinfected, so that the operator can easily clean and disinfect the liquid flow path without touching the cleaning / disinfectant. It can be carried out. Further, the dialysate supply device 300 of the present embodiment can supply the A agent, the B agent, and two types of cleaning / disinfecting agents to the pipe or the tank 15 by the single medicine input mechanism 20, and thus has a simple configuration. It can be. In addition, when the medicine or the cleaning agent is added, a series of processes such as rotation and positioning of the storage unit 720, sandwiching and removing of the container 21 by the first and second connectors 26 a and 26 b are collectively controlled by a command from the control unit 95. As a result, automation can be achieved, and the liquid channel can be easily cleaned and disinfected without the operator touching the cleaning / disinfectant. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
　更に、本実施形態の透析液供給装置３００は、制御部９５によってストレージ部７２０に保持するＡ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄの各本体２１Ａｅ、２１Ｂｅ、２１Ｃｅ、２１Ｄｅの形状を異ならせ、ストレージ部７２０の上円板７００には、各本体の形状に合わせた穴７０１～７０４を設けているので、Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄを入れ間違えないようにできる。また、各容器２１Ａ～２１ＤにＩＣチップ等を取り付けておき、制御部９５がストレージ部７２０を回転させてＡ剤容器２１Ａ、Ｂ剤容器２１Ｂ、或いは洗浄剤容器２１Ｃ、２１Ｄを選択する際にどの薬剤が充填されている容器２１であるかをＩＣチップの情報で判断するようにして正しい薬剤或いは洗浄剤の充填された容器２１が第１コネクタ２６ａと第２コネクタ２６ｂとの間の中心線５８０の上に位置するように制御して、薬剤の誤投入を防止することができる。 Furthermore, the dialysate supply device 300 according to the present embodiment includes the main bodies 21Ae, 21Be, 21Ce, and 21De of the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D that are held in the storage unit 720 by the control unit 95. The upper disc 700 of the storage unit 720 is provided with holes 701 to 704 according to the shape of each main body, so that the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D are provided. You can avoid mistakes. In addition, an IC chip or the like is attached to each container 21A to 21D, and the control unit 95 rotates the storage unit 720 to select the A agent container 21A, the B agent container 21B, or the cleaning agent containers 21C and 21D. The center line 580 between the first connector 26a and the second connector 26b is such that the container 21 filled with the correct medicine or cleaning agent is determined by determining whether the container 21 is filled with the medicine from the information on the IC chip. It is possible to prevent an erroneous injection of the medicine by controlling it so as to be positioned above.
　更に、本実施形態の透析液供給装置３００は、図１５に示すように、洗浄剤容器２１Ｃの上首部２１Ｃａと下首部２１Ｃｂとをそれぞれ第１、第２コネクタ２６ａ、２６ｂの第２、第４嵌合穴５１７、６１７にはめ込むと、先に図１４を参照して説明したＢ剤容器２１Ｂの上首部２１Ｂａと下首部２１Ｂｂとが嵌り込んでいた第１、第３嵌合穴５１５、６１５の内面と、上ノズル５０３、下ノズル６０３の各外面との間には空間ができる。このため、Ｂ剤容器２１Ｂが薬剤投入機構２０に取り付けられた際に上首部２１Ｂａ、下首部２１Ｂｂの外面が接触していた第１、第３嵌合穴５１５、６１５の内面にも洗浄液が通流することができ、各嵌合穴５１５、６１５の内側の接触面に残留したＢ剤或いはＡ剤を洗浄することができる。 Furthermore, as shown in FIG. 15, the dialysate supply apparatus 300 of the present embodiment connects the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C with the first and second connectors 26a and 26b, respectively. When fitted into the fitting holes 517 and 617, the first and third fitting holes 515 and 615 in which the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B described above with reference to FIG. There is a space between the inner surface and the outer surfaces of the upper nozzle 503 and the lower nozzle 603. For this reason, the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 that are in contact with the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb when the B agent container 21B is attached to the medicine injection mechanism 20. The B agent or the A agent remaining on the contact surface inside each fitting hole 515, 615 can be washed.
　次に図１８から図２０を参照しながら、他の実施形態の透析液供給装置４００について説明する。図１から図１７を参照して説明した実施形態と同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply apparatus 400 according to another embodiment will be described with reference to FIGS. Parts similar to those of the embodiment described with reference to FIGS. 1 to 17 are denoted by the same reference numerals and description thereof is omitted.
　図１８に示す透析液供給装置４００は、先に図７を参照して説明した透析液供給装置２００と同様、ＲＯ水管１３の中に高濃度のＡ剤、Ｂ剤を少しずつ連続的に投入して所定濃度の透析液を生成し、透析装置９６に供給するものである。本実施形態の薬剤投入機構６０の構成は、先に図１３から図１４を参照して説明した第１、第２コネクタ２６ａ、２６ｂ、コネクタ移動機構５６０と同様の構成の第１、第２コネクタ１２６ａ、１２６ｂ、コネクタ移動機構５６０を含んでおり、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄを取り付けることができるように構成されている。なお、図１１、図１２Ａ、図１２Ｂを参照して説明したストレージ部７２０は備えていない。また、先に説明した実施形態と同様、本実施形態の透析液供給装置４００は、透析液排出管８０にもう一つの洗浄剤投入機構１３０備え、透析液排出管８０とＲＯ水管１３とを接続するもう一つの再循環管１７８と、弁１７９とを備えている。 The dialysate supply device 400 shown in FIG. 18 is continuously charged with a high concentration of agent A and agent B into the RO water pipe 13 little by little, like the dialysate supply device 200 described above with reference to FIG. Thus, a dialysate having a predetermined concentration is generated and supplied to the dialyzer 96. The configuration of the medicine injection mechanism 60 of the present embodiment is the same as the first and second connectors 26a and 26b and the connector moving mechanism 560 described above with reference to FIGS. 126a, 126b, and a connector moving mechanism 560, which are configured so that the B agent container 21B and the cleaning agent containers 21C, 21D can be attached. Note that the storage unit 720 described with reference to FIGS. 11, 12A, and 12B is not provided. Similarly to the embodiment described above, the dialysate supply device 400 of this embodiment includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13. Another recirculation pipe 178 and a valve 179 are provided.
　図１８に示す透析液供給装置４００によって透析液を透析装置９６に供給する場合には、図１４に示すように、Ｂ剤容器２１Ｂの上首部２１Ｂａの外周に第１コネクタ１２６ａの第１嵌合穴５１５、パッキン５１６を嵌めこむと共に、Ｂ剤容器２１Ｂの下首部２１Ｂｂの外周に第２コネクタ１２６ｂの第３嵌合穴６１５、パッキン６１６を嵌めこむようにしてＢ剤容器２１Ｂを第１、第２コネクタ１２６ａ、１２６ｂの間に挟み込み、Ｂ剤容器２１Ｂ、入口管１２２と、出口管１２３と、が連通して１つの液体流路を形成するようにする。 When the dialysate is supplied to the dialyzer 96 by the dialysate supply device 400 shown in FIG. 18, as shown in FIG. 14, the first fitting of the first connector 126a is performed on the outer periphery of the upper neck portion 21Ba of the B agent container 21B. The B agent container 21B is fitted into the first and second connectors so that the hole 515 and the packing 516 are fitted, and the third fitting hole 615 and the packing 616 of the second connector 126b are fitted into the outer periphery of the lower neck portion 21Bb of the B agent container 21B. The B agent container 21B, the inlet pipe 122, and the outlet pipe 123 communicate with each other so as to form one liquid flow path.
　この状態で、弁１２４、１２５を開として、ＲＯ水をＢ剤容器２１Ｂに導入してＢ剤を溶解して濃度の高い溶液を生成し、Ｂ剤注入ポンプ４４でＲＯ水管１３の中に濃度のＢ剤の溶液を少しずつ注入する。また、Ａ剤は、Ａ剤注入ポンプ５３によってＡ剤タンク５１から濃度の高いＡ剤の溶液を吸い上げてＲＯ水管１３の中に少しずつ注入する。Ｂ剤注入ポンプ４４の注入量、Ａ剤注入ポンプ５３の注入量は、各注入ポンプ４４、５３の下流側のＲＯ水管１３に取り付けられた電導度センサ（図示せず）で検出した電導度に基づいて制御部９５が調整する。ＲＯ水管１３に注入されたＢ剤、Ａ剤の溶液は、図示しないミキシングチャンバで混合されて所定濃度透析液となり、透析装置９６に供給される。 In this state, the valves 124 and 125 are opened, the RO water is introduced into the B agent container 21B, the B agent is dissolved to produce a high concentration solution, and the B agent injection pump 44 has a concentration in the RO water pipe 13. B solution of B is injected little by little. In addition, the A agent is sucked up from the A agent tank 51 by the A agent injection pump 53 and injected into the RO water pipe 13 little by little. The injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by a conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44, 53. The control unit 95 adjusts based on this. The solutions of the B agent and the A agent injected into the RO water pipe 13 are mixed in a mixing chamber (not shown) to become a predetermined concentration dialysate and supplied to the dialyzer 96.
　以上のように構成された透析液供給装置４００の接液部の洗浄を行う場合の方法について図１９、図２０を参照しながら説明する。 A method for cleaning the wetted part of the dialysate supply apparatus 400 configured as described above will be described with reference to FIGS. 19 and 20.
　まず、弁１２４、１２５を閉として薬剤投入機構１２０の第１、第２コネクタ１２６ａ、１２６ｂの間に取り付けられているＢ剤容器２１Ｂを取り外し、洗浄剤容器２１Ｃを先に説明したのと同様の方法で第１、第２コネクタ１２６ａ、１２６ｂの間に取り付ける。この場合、図１５に示すように、洗浄剤容器２１Ｃの上首部２１Ｃａの外周に第１コネクタ１２６ａの第２嵌合穴５１７、パッキン５１８を嵌めこむと共に、洗浄剤容器２１Ｃの下首部２１Ｃｂの外周に第２コネクタ１２６ｂの第４嵌合穴６１７、パッキン６１８を嵌めこむようにして洗浄剤容器２１Ｃを第１、第２コネクタ１２６ａ、１２６ｂの間に挟み込み、洗浄剤容器２１Ｃ、入口管１２２と、出口管１２３とが連通して１つの液体流路を形成するようにする。 First, the valves 124 and 125 are closed, the B agent container 21B attached between the first and second connectors 126a and 126b of the medicine injection mechanism 120 is removed, and the cleaning agent container 21C is the same as described above. It attaches between the 1st, 2nd connectors 126a and 126b by a method. In this case, as shown in FIG. 15, the second fitting hole 517 and the packing 518 of the first connector 126a are fitted into the outer periphery of the upper neck portion 21Ca of the cleaning agent container 21C, and the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C. The cleaning agent container 21C is sandwiched between the first and second connectors 126a and 126b so that the fourth fitting hole 617 and the packing 618 of the second connector 126b are fitted into the first connector 126b, the cleaning agent container 21C, the inlet pipe 122, and the outlet pipe. 123 communicates with each other to form one liquid flow path.
　次に、Ａ剤投入機構５０の弁５４、透析液供給管７３の弁７７を閉とし、弁１２４、１２５、再循環管７８の弁７９を開とする。そして、ＲＯ装置１２から入口管１２２を通して洗浄剤容器２１ＣにＲＯ水を導入し、出口管１２３から洗浄・消毒液をＲＯ水管１３に流入させる。そして、送液ポンプ７０によって図１９に示す流路Ｒ４２のように、再循環管７８、薬剤投入機構１２０、送液ポンプ７０と洗浄・消毒液を循環させて一次洗浄を行う。 Next, the valve 54 of the agent A charging mechanism 50 and the valve 77 of the dialysate supply pipe 73 are closed, and the valves 124 and 125 and the valve 79 of the recirculation pipe 78 are opened. Then, RO water is introduced from the RO device 12 into the cleaning agent container 21 </ b> C through the inlet pipe 122, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 123. Then, the primary cleaning is performed by circulating the cleaning / disinfecting liquid through the recirculation pipe 78, the medicine feeding mechanism 120, the liquid feeding pump 70 and the cleaning / disinfecting liquid as shown in the flow path R42 shown in FIG.
　一次洗浄が終わったら、図２０に示す流路Ｒ４３によってＲＯ水を系統に注入しながら洗浄・消毒液をドレンから系外に排出する。また、ＲＯ水をもう一つの洗浄剤投入機構１３０に導入して洗浄・消毒液を生成し、図２０に示す流路Ｒ４４によって透析液排出管８０から再循環管１７８、ＲＯ水管１３、薬剤投入機構６０、送液ポンプ７０に循環させて、接液部の二次洗浄を行う。二次洗浄を行った後、ＲＯ水を図１９に示す流路Ｒ４２或いは図２０に示す流路Ｒ４４に循環させた後、図２０に示す流路Ｒ４３のようにドレンから系外に透析・洗浄液を排出して接液部のフラッシングを行い、洗浄・消毒作業を終了する。なお、洗浄剤投入機構１３０、再循環管１７８、弁１７９がない場合には、一次洗浄のみを行うようにしてもよい。 When the primary cleaning is completed, the cleaning / disinfecting liquid is discharged out of the system from the drain while injecting RO water into the system through the flow path R43 shown in FIG. Further, the RO water is introduced into another cleaning agent charging mechanism 130 to generate cleaning / disinfecting liquid, and the recirculation pipe 178, the RO water pipe 13, and the chemicals are input from the dialysate discharge pipe 80 through the flow path R44 shown in FIG. By circulating through the mechanism 60 and the liquid feed pump 70, the wetted part is subjected to secondary cleaning. After the secondary cleaning, RO water is circulated through the flow path R42 shown in FIG. 19 or the flow path R44 shown in FIG. 20, and then the dialysis / cleaning liquid is discharged from the drain to the outside as shown in the flow path R43 shown in FIG. The wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.
　以上説明したように、本実施形態の透析液供給装置４００に説明した各実施形態と同様、操作者が所定量の洗浄・消毒剤が充填・封止された洗浄剤容器２１Ｃを薬剤投入機構１２０の第１コネクタ１２６ａと第２コネクタ１２６ｂとの間にセットするだけで接液部の洗浄・消毒を行うことができるので、操作者が洗浄・消毒剤に触れることなく容易に液流路の洗浄・消毒作業を行うことができる。また、本実施形態の透析液供給装置４００の薬剤投入機構１２０の第１、第２コネクタ１２６ａ、１２６ｂは、薬剤容器と洗浄剤容器のいずれをも取り付けることができ、簡便な構成で透析液供給装置４００の洗浄・消毒を行うことができる。また、洗浄・消毒剤が大気に触れることが無くなるので、洗浄・消毒剤のにおいの拡散を抑えることができる。 As described above, as in each of the embodiments described in the dialysate supply apparatus 400 of this embodiment, the operator puts the cleaning agent container 21C filled and sealed with a predetermined amount of the cleaning / disinfectant into the medicine charging mechanism 120. Since the liquid contact part can be cleaned and disinfected by simply setting it between the first connector 126a and the second connector 126b, the operator can easily clean the liquid flow path without touching the cleaning / disinfectant.・ Can disinfect. Further, the first and second connectors 126a and 126b of the drug injection mechanism 120 of the dialysate supply apparatus 400 of the present embodiment can be attached with either a drug container or a cleaning agent container, and supply dialysate with a simple configuration. The apparatus 400 can be cleaned and disinfected. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.
　次に、図２１から図２８を参照しながら、他の実施形態の透析液供給装置８００について説明する。本実施形態の透析液供給装置８００は、先に図１０から図１７を参照して説明した透析液供給装置３００に、洗浄剤容器２１Ｃ、２１Ｄの下首部２１Ｃｂ、２１Ｄｂに接続された第２コネクタ２６ｂから洗浄剤容器２１Ｃ、２１Ｄの上首部２１Ｃａ、２１Ｄａに接続された第１コネクタ２６ａに洗浄・消毒液を逆流させる液体逆流機構８０１を追加したものである。また、本実施形態の透析液供給装置８００の制御部９５は、Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄを外側から光学的手段等で、各容器２１Ａ～２１Ｄ内の充填物を検出する充填状態検出センサ２１Ｓの信号が出力されるよう構成されている。以下の説明では、先に図１０から図１７を参照して説明した透析液供給装置３００と同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply device 800 according to another embodiment will be described with reference to FIGS. The dialysate supply device 800 of this embodiment is a second connector connected to the lower neck portions 21Cb and 21Db of the detergent containers 21C and 21D in the dialysate supply device 300 described above with reference to FIGS. A liquid backflow mechanism 801 for backflowing the cleaning / disinfecting liquid is added to the first connector 26a connected to the upper neck portions 21Ca and 21Da of the cleaning agent containers 21C and 21D from 26b. In addition, the control unit 95 of the dialysate supply apparatus 800 according to the present embodiment fills the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D into the containers 21A to 21D by optical means or the like from the outside. A signal of a filling state detection sensor 21S for detecting an object is output. In the following description, parts similar to those of the dialysate supply apparatus 300 described above with reference to FIGS. 10 to 17 are denoted by the same reference numerals, and description thereof is omitted.
　図２１に示すように、本実施形態の透析液供給装置８００は、入口管２２に配置された弁２４の上流側から分岐して出口管２３の弁２５と第２コネクタ２６ｂとの間を接続する第１バイパス管２２ａと、入口管２２の弁２４と第１コネクタ２６ａとの間から分岐して出口管２３の弁２５の下流側との間を接続する第２バイパス管２３ａとを有している。第１バイパス管２２ａには、弁２４ａが配置され、第２バイパス管２３ａには、弁２５ａが配置されている。第１バイパス管２２ａ、第２バイパス管２３ａ、弁２４ａ、２５ａ、及び、入口管２２、出口管２３、弁２４、２５とは、第２コネクタ２６ｂから第１コネクタ２６ａに洗浄・消毒液を逆流させる液体逆流機構８０１を構成する。 As shown in FIG. 21, the dialysate supply device 800 of this embodiment branches from the upstream side of the valve 24 arranged in the inlet pipe 22 and connects between the valve 25 of the outlet pipe 23 and the second connector 26b. A first bypass pipe 22a, and a second bypass pipe 23a that branches from between the valve 24 of the inlet pipe 22 and the first connector 26a and connects the downstream side of the valve 25 of the outlet pipe 23. ing. A valve 24a is disposed in the first bypass pipe 22a, and a valve 25a is disposed in the second bypass pipe 23a. The first bypass pipe 22a, the second bypass pipe 23a, the valves 24a and 25a, and the inlet pipe 22, the outlet pipe 23, and the valves 24 and 25 flow back the cleaning / disinfecting liquid from the second connector 26b to the first connector 26a. The liquid reverse flow mechanism 801 is configured.
　図２２に示すように、本実施形態の透析液供給装置８００には、ストレージ部７２０にセットされるＡ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄの中の充填物の有無を検出する充填状態検出センサ２１Ｓが取り付けられている。充填状態検出センサ２１Ｓは、各容器２１Ａ～２１Ｄの中に粉あるいは液体が充填されているかどうかを検出してその信号を図２１に示す制御部９５に出力するものである。本実施形態では、充填状態検出センサ２１Ｓは、図２２に示すように、充填状態検出センサ２１Ｓの設置位置に回転してきた各容器２１Ａ～２１Ｄ中に光を当て、透過した光によって充填物の有無を検出する透過型光学センサである。なお、充填状態検出センサ２１Ｓは、透過型光学センサに限らず、例えば、赤外光が液体により吸収される特性を利用したＬＥＤ光吸収式センサであってもよいし、色識別センサ、反射型光電センサ等であってもよい。また、充填状態検出センサ２１Ｓは、各容器２１Ａ～２１Ｄの中心線が第１コネクタ２６ａと第２コネクタ２６の中心線５８０と一致する位置に回転してきた際に各容器２１Ａ～２１Ｄの充填物の有無の検出を行うようにしてもよいし、ストレージ部７２０にセットされた各容器２１Ａ～２１Ｄが回転中に各容器２１Ａ～２１Ｄの充填物の有無の検出を行うようにしてもよい。以上のように構成された透析液供給装置８００の動作および、洗浄剤容器２１Ｃを薬剤投入機構２０に取り付けて透析液供給装置８００の接液部の洗浄・消毒を行う方法について説明する。 As shown in FIG. 22, the dialysate supply apparatus 800 of the present embodiment determines whether or not there is a filler in the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D set in the storage unit 720. A filling state detection sensor 21S to be detected is attached. The filling state detection sensor 21S detects whether or not the containers 21A to 21D are filled with powder or liquid and outputs the signal to the control unit 95 shown in FIG. In the present embodiment, as shown in FIG. 22, the filling state detection sensor 21S applies light to each of the containers 21A to 21D that has been rotated to the installation position of the filling state detection sensor 21S, and the presence or absence of a filling by the transmitted light. It is a transmissive optical sensor for detecting. The filling state detection sensor 21S is not limited to a transmissive optical sensor, and may be, for example, an LED light absorption sensor that uses a characteristic that infrared light is absorbed by a liquid, a color identification sensor, a reflection type sensor, or the like. It may be a photoelectric sensor or the like. In addition, the filling state detection sensor 21S detects the filling of each container 21A to 21D when the center line of each container 21A to 21D rotates to a position where it matches the center line 580 of the first connector 26a and the second connector 26. The presence / absence detection may be performed, or the presence / absence of the filling in each of the containers 21A to 21D may be detected while the containers 21A to 21D set in the storage unit 720 are rotating. The operation of the dialysate supply device 800 configured as described above and a method for cleaning and disinfecting the liquid contact portion of the dialysate supply device 800 by attaching the cleaning agent container 21C to the medicine charging mechanism 20 will be described.
　先に図１４、図１５を参照して説明したと同様、図２２に示すように、Ａ剤容器２１Ａ、Ｂ剤容器２１Ｂ、洗浄剤容器２１Ｃ、２１Ｄをストレージ部７２０の穴７０１～７０４にセットする。先に説明したように、図２２に示すように、透析液供給装置８００には、各容器２１Ａ～２１Ｄの充填状態を検出する充填状態検出センサ２１Ｓが配置されている。そして図２１に示すように、充填状態検出センサ２１Ｓの信号が制御部９５に出力される。制御部９５は、充填状態検出センサ２１Ｓからの信号がＡ剤容器２１ＡあるいはＢ剤容器２１Ｂが空であることを示すものである場合、透析液供給装置８００の動作を停止し、透析装置９６への透析液の供給を停止する。また、必要により、空のＡ剤容器２１Ａ、または空のＢ剤容器２１Ｂがストレージ部７２０にセットされているアラームを発報する。 As described with reference to FIGS. 14 and 15, the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D are set in the holes 701 to 704 of the storage unit 720 as shown in FIG. To do. As described above, as shown in FIG. 22, the dialysate supply device 800 is provided with the filling state detection sensor 21S for detecting the filling state of the containers 21A to 21D. Then, as shown in FIG. 21, a signal from the filling state detection sensor 21 </ b> S is output to the control unit 95. When the signal from the filling state detection sensor 21S indicates that the agent A container 21A or the agent B container 21B is empty, the control unit 95 stops the operation of the dialysate supply device 800 and sends it to the dialyzer 96. Stop supplying the dialysate. If necessary, an alarm that an empty agent container 21A or an empty agent B container 21B is set in the storage unit 720 is issued.
　これにより、使用済みなど空のＡ剤容器２１Ａ、あるいは空のＢ剤容器２１Ｂを誤ってストレージ部７２０にセットして適正濃度範囲外の透析液が供給されることを抑制できる。また、適正濃度範囲外の透析液が供給され、透析治療開始後に透析液供給装置８００に取り付けられている電気伝導度センサ（図示せず）によって透析液の供給が停止され、治療時間が遅れ、治療の中断、中止を抑制することができる。 Thereby, it is possible to prevent the empty A agent container 21A such as used or the empty B agent container 21B from being set in the storage unit 720 by mistake and supplying the dialysate outside the appropriate concentration range. In addition, dialysate outside the appropriate concentration range is supplied, and after the start of dialysis treatment, the dialysate supply is stopped by an electrical conductivity sensor (not shown) attached to the dialysate supply device 800, and the treatment time is delayed. The interruption and discontinuation of treatment can be suppressed.
　また、制御部９５は、充填状態検出センサ２１Ｓからの信号が洗浄剤容器２１Ｃ、２１Ｄが空であることを示すものである場合、透析液供給装置８００の洗浄動作を停止し、必要により、空の洗浄剤容器２１Ｃ、２１Ｄがストレージ部７２０にセットされているアラームを発報する。 In addition, when the signal from the filling state detection sensor 21S indicates that the cleaning agent containers 21C and 21D are empty, the control unit 95 stops the cleaning operation of the dialysate supply device 800, and if necessary, Alarms that the cleaning agent containers 21C and 21D are set in the storage unit 720 are issued.
　これにより、洗浄・消毒効果の得られないＲＯ水のみの水洗浄が行われ、電磁弁やセンサ電極に付着した炭酸カルシウムが除去できず透析液供給装置８００の正常な動作が確保できなくなることを抑制し、蛋白質や脂肪、細菌の除去ができていない状態で洗浄・消毒動作が終了してしまうことを抑制することができる。 As a result, only RO water that cannot be cleaned and disinfected can be washed, and calcium carbonate adhering to the solenoid valve or sensor electrode cannot be removed, so that normal operation of the dialysate supply device 800 cannot be ensured. It is possible to suppress the completion of the cleaning / disinfecting operation in a state where protein, fat and bacteria are not removed.
　制御部９５がストレージ部７２０に配置されている充填状態検出センサ２１Ｓからの信号により、洗浄剤容器２１Ｃが空ではなく、洗浄剤容器２１Ｃには、洗浄・消毒剤が十分に充填されたものであることを確認したら、先に、図１４、図１５を参照して説明したように、制御部９５は、ストレージ部７２０を回転させ、洗浄剤容器２１Ｃの中心が第１、第２コネクタ２６ａ、２６ｂの中心線５８０と同一とした後、コネクタ移動機構５６０を動作させて洗浄剤容器２１Ｃを第１コネクタ２６ａ、第２コネクタ２６ｂの間に取り付ける。 According to the signal from the filling state detection sensor 21S arranged in the storage unit 720, the controller 95 is not empty, and the cleaner container 21C is sufficiently filled with the cleaning / disinfectant. After confirming that there is a control, the control unit 95 rotates the storage unit 720 so that the center of the cleaning agent container 21C is the first, second connector 26a, as described above with reference to FIGS. After the same as the center line 580 of 26b, the connector moving mechanism 560 is operated to attach the cleaning agent container 21C between the first connector 26a and the second connector 26b.
　洗浄剤容器２１Ｃを第１コネクタ２６ａ、第２コネクタ２６ｂの間に取り付けたら、図２３に示すように、第１バイパス管２２ａの弁２４ａと第２バイパス管２３ａの弁２５ａとを閉とし、入口管２２の弁２４と出口管２３の弁２５を開とする。すると、図２４に示すように、ＲＯ水が入口管２２から第１コネクタ２６ａの平板５０１の流通孔５０２に流れ込んでくる。流通孔５０２に流れ込んだＲＯ水は、図２４に示すように、上ノズル５０３の流通孔５０４を通って上ノズル５０３の先端側の流通孔５０５から洗浄剤容器２１Ｃに流入する。洗浄剤容器２１Ｃの中に充填されている洗浄・消毒剤が粉末状態の場合には、洗浄剤容器２１Ｃの中で洗浄・消毒剤がＲＯ水中に溶解して濃度の高い洗浄・消毒液となり、下ノズル６０３の流通孔６０５、６０４から平板６０１の流通孔６０２を通って出口管２３から流出する。そして、図２３の流路Ｒ３１に示すように、薬剤投入管１４を通ってタンク１５の中に流入する。水供給ポンプ１１は、タンク１５の中の洗浄・消毒液の濃度が所定の濃度になるまで、ＲＯ装置１２からＲＯ水をタンク１５に供給する。そしてタンク１５内の洗浄・消毒剤の濃度が所定の濃度に達したら、或いは、所定量のＲＯ水をタンク１５に供給したら、水供給ポンプ１１を停止する。 When the cleaning agent container 21C is attached between the first connector 26a and the second connector 26b, the valve 24a of the first bypass pipe 22a and the valve 25a of the second bypass pipe 23a are closed as shown in FIG. The valve 24 of the pipe 22 and the valve 25 of the outlet pipe 23 are opened. Then, as shown in FIG. 24, RO water flows from the inlet pipe 22 into the flow hole 502 of the flat plate 501 of the first connector 26a. As shown in FIG. 24, the RO water that has flowed into the flow hole 502 flows into the cleaning agent container 21 </ b> C from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503. When the cleaning / disinfecting agent filled in the cleaning agent container 21C is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 21C to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 23 through the flow holes 605 and 604 of the lower nozzle 603, through the flow holes 602 of the flat plate 601. Then, as shown in a flow path R31 of FIG. The water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.
　次に、弁７７、１７９を閉として弁７９を開として、送液ポンプ７０を始動すると、タンク１５に貯留されている洗浄・消毒液は、図２３に一点鎖線で示す流路Ｒ３２のように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→再循環管７８（弁７９）→ＲＯ水管１３→薬剤投入機構２０→薬剤投入管１４→タンク１５］と循環し、各機器及び配管の接液部を洗浄・消毒する。その際、洗浄・消毒液は、図２４に示すように、第３嵌合穴６１５の内面と下ノズル６０３の外面との間の空間６２０に流れ込んで、第３嵌合穴６１５の内面の洗浄を行う。 Next, when the valves 77 and 179 are closed and the valve 79 is opened and the liquid feed pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is like a flow path R32 indicated by a one-dot chain line in FIG. [Tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → drug injection mechanism 20 → drug injection pipe 14 → Tank 15] to circulate and clean and disinfect the wetted parts of each device and piping. At that time, as shown in FIG. 24, the cleaning / disinfecting liquid flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603, and cleans the inner surface of the third fitting hole 615. I do.
　図２３に示す流路Ｒ３２の洗浄・消毒を所定時間だけ行ったら送液ポンプ７０を停止し、図２５に示すように、第１バイパス管２２ａの弁２４ａと、第２バイパス管２３ａの弁２５ａとを開とし、入口管２２の弁２４と出口管２３の弁２５とを閉とする。そして、送液ポンプ７０を始動すると、タンク１５に貯留されている洗浄・消毒液は、図２３に一点鎖線で示す流路Ｒ３２ａのように、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→再循環管７８（弁７９）→ＲＯ水管１３→第１バイパス管２２ａ→第２コネクタ２６ｂ→洗浄剤容器２１Ｃ→第１コネクタ２６ａ→第２バイパス管２３ａ→薬剤投入管１４→タンク１５］と循環する。この際、図２６に示すように、洗浄・消毒液は、出口管２３から平板６０１の流通孔６０２を通って下ノズル６０３の流通孔６０４、６０５から洗浄剤容器２１Ｃの中に流れ込む。また、洗浄・消毒液は、第３嵌合穴６１５の内面と下ノズル６０３の外面との間の空間６２０にも流れ込んで、第３嵌合穴６１５の内面の洗浄・消毒を行う。洗浄剤容器２１Ｃの中に流入した洗浄・消毒液は、上ノズル５０３の先端側の流通孔５０５から上ノズル５０３の流通孔５０４を通って第１コネクタ２６ａの平板５０１の流通孔５０２に流れていく。また、洗浄剤容器２１Ｃに流入した洗浄・消毒液は、上ノズル５０３と上首部２１Ｃａのシール部材２１Ｃｃとの隙間から、第１嵌合穴５１５の内面と上ノズル５０３の外面と間の空間５２０に流れ込み、第１嵌合穴５１５の内面の洗浄・消毒を行う。図２５に示す流路Ｒ３２ａの洗浄・消毒を所定時間行ったら、流路Ｒ３２ａの洗浄・消毒を終了する。 When cleaning / disinfection of the flow path R32 shown in FIG. 23 is performed for a predetermined time, the liquid feed pump 70 is stopped, and as shown in FIG. 25, the valve 24a of the first bypass pipe 22a and the valve 25a of the second bypass pipe 23a. And the valve 24 of the inlet pipe 22 and the valve 25 of the outlet pipe 23 are closed. Then, when the liquid feeding pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 → pump suction pipe 16 → liquid feeding pump 70 as shown by a flow path R32a indicated by a one-dot chain line in FIG. → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → first bypass pipe 22a → second connector 26b → cleaning agent container 21C → first connector 26a → first 2 bypass pipe 23a → drug input pipe 14 → tank 15]. At this time, as shown in FIG. 26, the cleaning / disinfecting liquid flows from the outlet pipe 23 through the flow holes 602 of the flat plate 601 into the cleaning agent container 21C through the flow holes 604 and 605 of the lower nozzle 603. The cleaning / disinfecting liquid also flows into the space 620 between the inner surface of the third fitting hole 615 and the outer surface of the lower nozzle 603 to clean and disinfect the inner surface of the third fitting hole 615. The cleaning / disinfecting liquid that has flowed into the cleaning agent container 21C flows from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503 to the flow hole 502 of the flat plate 501 of the first connector 26a. Go. Further, the cleaning / disinfecting liquid that has flowed into the cleaning agent container 21 </ b> C is a space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503 from the gap between the upper nozzle 503 and the sealing member 21 </ b> Cc of the upper neck portion 21 </ b> Ca. The inner surface of the first fitting hole 515 is cleaned and disinfected. When the cleaning / disinfection of the flow path R32a shown in FIG. 25 is performed for a predetermined time, the cleaning / disinfection of the flow path R32a is ended.
　流路Ｒ３２、流路Ｒ３２ａの洗浄・消毒が終了したら、先に図１７を参照して説明したと同様、タンク１５に貯留した洗浄・消毒液を図１７に示す流路Ｒ３３によって全てドレンから系外に排出して透析液供給装置８００接液部の一次洗浄を終了する。 When the cleaning and disinfection of the flow path R32 and the flow path R32a are completed, the cleaning / disinfecting liquid stored in the tank 15 is completely drained from the drain by the flow path R33 shown in FIG. 17 as described above with reference to FIG. The primary cleaning of the dialysate supply device 800 in contact with the liquid is finished by discharging to the outside.
　以上説明したように、本実施形態の透析液供給装置８００は、液体逆流機構８０１によって図２５に示す流路Ｒ３２ａを形成し、洗浄・消毒液を下側の第２コネクタ２６ｂから上側の第１コネクタ２６ａに向かって逆流させる。これにより、図２３に示す流路Ｒ３２で洗浄・消毒液を循環させた際に、洗浄・消毒が不十分となりがちな第１嵌合穴５１５の内面と上ノズル５０３の外面と間の空間５２０に洗浄・消毒液を流れ込ませて、第１嵌合穴５１５の内面の洗浄・消毒を十分に行うことができる。 As described above, the dialysate supply device 800 of the present embodiment forms the flow path R32a shown in FIG. 25 by the liquid backflow mechanism 801, and supplies the cleaning / disinfectant liquid from the lower second connector 26b to the upper first. The flow is reversed toward the connector 26a. Accordingly, when the cleaning / disinfecting liquid is circulated in the flow path R32 shown in FIG. 23, the space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503, which are likely to be insufficiently cleaned and disinfected. The cleaning / disinfecting liquid can be poured into the first fitting hole 515 to sufficiently clean and disinfect the inner surface of the first fitting hole 515.
　以上の説明では、洗浄剤容器２１Ｃ、２１Ｄには、粉末状の洗浄・消毒剤を充填しておき、ＲＯ水によりこれを溶解して所定濃度の洗浄・消毒液とすることとして説明したが、洗浄剤容器２１Ｃ、２１Ｄに液体の洗浄・消毒液を充填し、これによって透析液供給装置８００の洗浄・消毒を行う場合がある。この場合、洗浄剤容器２１Ｃの下首部２１Ｃｂが第４嵌合穴６１７のパッキン６１８に嵌め込まれて下首部２１Ｃｂの外面と、第４嵌合穴６１７のパッキン６１８とで構成される第４嵌合部とが水密となる前に、下首部２１Ｃｂのシール部材２１Ｃｄが下ノズル６０３の先端がシール部材２１Ｃｄを貫通してしまうと、洗浄・消毒液が洗浄剤容器２１Ｃの下側に漏れ出してしまう場合がある。そこで、本実施形態の透析液供給装置８００は、図２７、２８に示すように、下ノズル６０３は、洗浄剤容器２１Ｃの下首部２１Ｃｂを第４嵌合穴６１７に水密に嵌め込む際に、洗浄剤容器２１Ｃの下首部２１Ｃｂと第４嵌合穴６１７とパッキン６１８とで構成される第４嵌合部とが水密となった際に、下ノズル６０３の先端とシール部材２１Ｃｄとの間に隙間Ｓがあり、洗浄剤容器２１Ｃの下首部２１Ｃｂと第４嵌合部とが水密となった後に、下首部２１Ｃｂの端面をシールするシール部材２１Ｃｄを下ノズル６０３の先端が貫通するように配置されている。これにより、洗浄剤容器２１Ｃに洗浄・消毒液を充填した場合であっても、洗浄・消毒液を外部に漏らさないようにして洗浄剤容器２１Ｃを薬剤投入機構２０に取り付けることができる。 In the above description, the cleaning agent containers 21C and 21D are filled with powdery cleaning / disinfecting agent and dissolved with RO water to obtain a predetermined concentration of cleaning / disinfecting solution. In some cases, the cleaning agent containers 21C and 21D are filled with a liquid cleaning / disinfecting liquid, whereby the dialysate supply device 800 is cleaned and disinfected. In this case, the lower neck portion 21Cb of the cleaning agent container 21C is fitted into the packing 618 of the fourth fitting hole 617, and the fourth fitting is configured by the outer surface of the lower neck portion 21Cb and the packing 618 of the fourth fitting hole 617. If the seal member 21Cd of the lower neck portion 21Cb penetrates the seal member 21Cd before the seal portion becomes watertight, the cleaning / disinfecting liquid leaks to the lower side of the cleaning agent container 21C. There is a case. Therefore, as shown in FIGS. 27 and 28, the dialysate supply device 800 of the present embodiment is configured so that the lower nozzle 603 fits the lower neck portion 21 </ b> Cb of the cleaning agent container 21 </ b> C into the fourth fitting hole 617 in a watertight manner. When the lower neck portion 21Cb of the cleaning agent container 21C, the fourth fitting hole formed by the fourth fitting hole 617, and the packing 618 becomes watertight, the gap between the tip of the lower nozzle 603 and the sealing member 21Cd After the lower neck portion 21Cb and the fourth fitting portion of the cleaning agent container 21C are watertight, there is a gap S, and the tip of the lower nozzle 603 is disposed so as to penetrate the sealing member 21Cd that seals the end surface of the lower neck portion 21Cb. Has been. Thus, even when the cleaning agent container 21C is filled with the cleaning / disinfecting liquid, the cleaning agent container 21C can be attached to the medicine charging mechanism 20 without leaking the cleaning / disinfecting liquid to the outside.
　次に、図２９から図３０を参照しながら、他の実施形態の透析液供給装置８５０について説明する。本実施形態の透析液供給装置８５０は、先に図１８から図２０を参照して説明した透析液供給装置４００の第２コネクタ１２６ｂから第１コネクタ１２６ａに洗浄・消毒液を逆流させるように、送液ポンプ７０、Ｂ剤注入ポンプ４４により洗浄・消毒液を逆流させる液体逆流機構８０２、８０３を追加したものである。以下の説明では、先に図１８から図２０を参照して説明した透析液供給装置４００と同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply device 850 according to another embodiment will be described with reference to FIGS. 29 to 30. The dialysate supply device 850 of this embodiment is configured so that the cleaning / disinfectant solution flows backward from the second connector 126b of the dialysate supply device 400 described above with reference to FIGS. 18 to 20 to the first connector 126a. Liquid backflow mechanisms 802 and 803 for backflowing the cleaning / disinfecting liquid by the liquid feed pump 70 and the B agent injection pump 44 are added. In the following description, parts similar to those of the dialysate supply apparatus 400 described above with reference to FIGS. 18 to 20 are denoted by the same reference numerals, and description thereof is omitted.
　図２９に示すように、本実施形態の透析液供給装置８５０は、ヒータ入口管７１の送液ポンプ７０の上流側と下流側に弁７０ａ、７０ｂを配置し、上流側の弁７０ａの上流側から分岐して送液ポンプ７０と弁７０ｂとの間に合流する第１ポンプバイパス管７１ａと、送液ポンプ７０の入口と弁７０ａとの間から分岐して弁７０ｂの下流側に合流する第２ポンプバイパス管７１ｂとを配置し、第１ポンプバイパス管７１ａに弁７０ｃを配置し、第２ポンプバイパス管７１ｂに弁７０ｂを配置している。弁７０ａ～７０ｄ、第１、第２ポンプバイパス管７１ａ、７１ｂは、送液ポンプ７０により洗浄・消毒液を逆流させる液体逆流機構８０２を構成する。また、出口管１２３のＢ剤注入ポンプ４４の上流側と下流側に弁１２５ａ、１２５ｂを配置し、上流側の弁１２５ａの上流側から分岐してＢ剤注入ポンプ４４と弁１２５ｂとの間に合流する第１ポンプバイパス管１２３ａと、Ｂ剤注入ポンプ４４の入口と弁１２５ａとの間から分岐して１２５ｂの下流側に合流する第２ポンプバイパス管１２３ｂとを配置し、第１ポンプバイパス管１２３ａに弁１２３ｃを配置し、第２ポンプバイパス管１２３ｂに弁１２５ｄを配置している。弁１２５ａ～１２５ｄ、第１、第２ポンプバイパス管１２３ａ、１２３ｂは、Ｂ剤注入ポンプ４４により洗浄・消毒液を逆流させる液体逆流機構８０３を構成する。 As shown in FIG. 29, in the dialysate supply device 850 of this embodiment, valves 70a and 70b are arranged on the upstream side and the downstream side of the liquid feed pump 70 of the heater inlet pipe 71, and the upstream side of the upstream valve 70a. The first pump bypass pipe 71a branching from the liquid feed pump 70 and the valve 70b, and the first pump bypass pipe 71a branching from between the inlet of the liquid feed pump 70 and the valve 70a to join the downstream side of the valve 70b. A two-pump bypass pipe 71b, a valve 70c in the first pump bypass pipe 71a, and a valve 70b in the second pump bypass pipe 71b. The valves 70a to 70d and the first and second pump bypass pipes 71a and 71b constitute a liquid backflow mechanism 802 that allows the cleaning / disinfecting liquid to flow backward by the liquid feeding pump 70. Further, valves 125a and 125b are arranged on the upstream side and the downstream side of the B agent injection pump 44 in the outlet pipe 123, branch from the upstream side of the upstream valve 125a, and between the B agent injection pump 44 and the valve 125b. A first pump bypass pipe 123a that merges and a second pump bypass pipe 123b that branches from the inlet of the B agent injection pump 44 and the valve 125a and merges downstream of 125b are arranged, and the first pump bypass pipe A valve 123c is arranged at 123a, and a valve 125d is arranged at the second pump bypass pipe 123b. The valves 125 a to 125 d and the first and second pump bypass pipes 123 a and 123 b constitute a liquid backflow mechanism 803 that causes the cleaning / disinfecting liquid to flow back by the B agent injection pump 44.
　図２９に示すように、弁７０ａ、７０ｂ、１２５ａ、１２５ｂを開、弁７０ｃ、７０ｄ、１２５ｃ、１２５ｄを閉として送液ポンプ７０とＢ剤注入ポンプを動作させると、図２９に一点鎖線で示す流路Ｒ４２ａのように、洗浄・消毒剤は、第１コネクタ１２６ａから第２コネクタ１２６ｂに向かって洗浄剤容器２１Ｃの中を流れる。この際の洗浄剤容器２１Ｃの中の洗浄・消毒剤の流れは、図２４を参照して説明したと同様である。 As shown in FIG. 29, when the valves 70a, 70b, 125a, and 125b are opened and the valves 70c, 70d, 125c, and 125d are closed, and the liquid feeding pump 70 and the B agent infusion pump are operated, FIG. As in the flow path R42a, the cleaning / disinfecting agent flows in the cleaning agent container 21C from the first connector 126a toward the second connector 126b. The flow of the cleaning / disinfectant in the cleaning agent container 21C at this time is the same as described with reference to FIG.
　逆に、図３０に示すように、弁７０ａ、７０ｂ、１２５ａ、１２５ｂを閉、弁７０ｃ、７０ｄ、１２５ｃ、１２５ｄを開として送液ポンプ７０とＢ剤注入ポンプを動作させると、図３０に一点鎖線で示す流路Ｒ４２ｂのように、洗浄・消毒剤は、第２コネクタ１２６ｂから第１コネクタ１２６ａに向かって洗浄剤容器２１Ｃの中を逆方向に流れる。この際の洗浄剤容器２１Ｃの中の洗浄・消毒剤の流れは、図２６を参照して説明したと同様である。 On the contrary, as shown in FIG. 30, when the valves 70 a, 70 b, 125 a, 125 b are closed and the valves 70 c, 70 d, 125 c, 125 d are opened and the liquid feed pump 70 and the B agent injection pump are operated, one point is shown in FIG. 30. Like the flow path R42b indicated by the chain line, the cleaning / disinfecting agent flows in the reverse direction through the cleaning agent container 21C from the second connector 126b toward the first connector 126a. The flow of the cleaning / disinfectant in the cleaning agent container 21C at this time is the same as described with reference to FIG.
　以上説明した透析液供給装置８５０は、先に説明した透析液供給装置８００と同様、液体逆流機構８０２、８０３によって図３０に一点鎖線で示す流路Ｒ４２ｂを形成し、洗浄・消毒液を下側の第２コネクタ１２６ｂから上側の第１コネクタ１２６ａに向かって逆流させる。これにより、図２３に示す流路Ｒ３２で洗浄・消毒液を循環させた際に、洗浄・消毒が不十分となりがちな第１嵌合穴５１５の内面と上ノズル５０３の外面と間の空間５２０に洗浄・消毒液を流れ込ませて、第１嵌合穴５１５の内面の洗浄・消毒を十分に行うことができる。 The dialysate supply device 850 described above forms a flow path R42b indicated by a one-dot chain line in FIG. 30 by the liquid backflow mechanisms 802 and 803 as in the dialysate supply device 800 described above, and the cleaning / disinfecting solution is placed on the lower side. Back flow from the second connector 126b toward the upper first connector 126a. Accordingly, when the cleaning / disinfecting liquid is circulated in the flow path R32 shown in FIG. 23, the space 520 between the inner surface of the first fitting hole 515 and the outer surface of the upper nozzle 503, which are likely to be insufficiently cleaned and disinfected. The cleaning / disinfecting liquid can be poured into the first fitting hole 515 to sufficiently clean and disinfect the inner surface of the first fitting hole 515.
　なお、図２９、図３０を参照して説明した透析液供給装置８５０において、液体逆流機構８０２、８０３を設けず、送液ポンプ７０、Ｂ剤注入ポンプ４４を逆転させて、図３０の流路洗浄・消毒剤を図３０に一点鎖線で示す流路Ｒ４２ｂのように流して、洗浄・消毒液を下側の第２コネクタ１２６ｂから上側の第１コネクタ１２６ａに向かって逆流させるようにしてもよい。 In the dialysate supply device 850 described with reference to FIGS. 29 and 30, the liquid backflow mechanisms 802 and 803 are not provided, but the liquid feed pump 70 and the B agent injection pump 44 are reversed, and the flow path of FIG. The cleaning / disinfectant may be caused to flow like a flow path R42b shown by a one-dot chain line in FIG. 30 so that the cleaning / disinfecting liquid flows backward from the lower second connector 126b toward the upper first connector 126a. .
　次に、図３１から図３６を参照して他の実施形態である透析液供給装置９００について説明する。本実施形態の透析液供給装置９００は、先に図１０から図１７を参照して説明した透析液供給装置３００でＲＯ装置１２とタンク１５との間に配置されていた薬剤投入機構２０をタンク１５と並列に配置し、タンク１５に貯留したＲＯ水を送液ポンプ１７０で薬剤投入機構２０に循環させ、接液部を洗浄・消毒する洗浄・消毒液としてタンク１５に貯留するようにしたものである。本実施形態の透析液供給装置９００では、送液ポンプ１７０は、ダイヤフラム式ポンプである。また、本実施形態の透析液供給装置９００は、先に図２１を参照して説明した透析液供給装置８００と同様、各容器２１Ａ～２１Ｄの充填状態を検出する充填状態検出センサ２１Ｓを備えている。以下の説明では、図１０から図１７、図２１から図２６を参照して説明したと同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply apparatus 900 according to another embodiment will be described with reference to FIGS. The dialysate supply device 900 according to the present embodiment uses the dialysate supply device 300 described above with reference to FIGS. 10 to 17 as the tank for the medicine input mechanism 20 disposed between the RO device 12 and the tank 15. The RO water stored in the tank 15 is circulated to the medicine charging mechanism 20 by the liquid feed pump 170 and stored in the tank 15 as a cleaning / disinfecting liquid for cleaning / disinfecting the liquid contact part. It is. In the dialysate supply apparatus 900 of this embodiment, the liquid feed pump 170 is a diaphragm pump. Further, the dialysate supply device 900 of this embodiment includes a filling state detection sensor 21S that detects the filling state of each of the containers 21A to 21D, similarly to the dialysate supply device 800 described above with reference to FIG. Yes. In the following description, the same parts as those described with reference to FIG. 10 to FIG. 17 and FIG. 21 to FIG.
　図３１に示すように、本実施形態の透析液供給装置９００では、ＲＯ装置１２とタンク１５との間は、ＲＯ水管１３で接続されており、ＲＯ水管１３には逆止弁１３ａが配置されている。 As shown in FIG. 31, in the dialysate supply device 900 of this embodiment, the RO device 12 and the tank 15 are connected by an RO water pipe 13, and a check valve 13 a is arranged in the RO water pipe 13. ing.
　本実施形態の透析液供給装置９００では、薬剤投入機構２０はタンク１５と並列で、第１コネクタ２６ａが下側、第２コネクタ２６ｂが上側となる様に配置されている。また、薬剤投入機構２０は、タンク１５の天井面よりも高い位置に配置されている。第１コネクタ２６ａとタンク１５の下部との間は入口管２２で接続され、入口管２２には、送液ポンプ１７０が配置されている。また、第２コネクタ２６ｂには出口管２３が接続され、出口管２３はタンク１５の上部に接続される薬剤投入管１４に接続されている。また、入口管２２とタンク１５の上部との間は容器内液抜き管１４ａで接続されている。容器内液抜き管１４ａは、タンク１５の天井面よりも高い位置に配置され、容器内液抜き管１４ａには容器内液抜き用弁１４ｂが取り付けられている。 In the dialysate supply device 900 of the present embodiment, the medicine charging mechanism 20 is arranged in parallel with the tank 15 so that the first connector 26a is on the lower side and the second connector 26b is on the upper side. Further, the medicine charging mechanism 20 is disposed at a position higher than the ceiling surface of the tank 15. The first connector 26 a and the lower portion of the tank 15 are connected by an inlet pipe 22, and a liquid feed pump 170 is disposed in the inlet pipe 22. In addition, an outlet pipe 23 is connected to the second connector 26 b, and the outlet pipe 23 is connected to the medicine input pipe 14 connected to the upper part of the tank 15. The inlet pipe 22 and the upper part of the tank 15 are connected by a liquid drain pipe 14a. The in-container liquid drain pipe 14a is disposed at a position higher than the ceiling surface of the tank 15, and the in-container liquid drain pipe 14a is provided with an in-container liquid drain pipe 14b.
　本実施形態の透析液供給装置９００の接続管７６のカプラ８１側には弁７７ａが配置され、弁７７ａの上流側と透析液排出管８０との間はバイパス管８０ａで接続されている。バイパス管８０ａには、弁８０ｂが配置されている。また、送液ポンプ７０の下流側と再循環管７８との間には、第２再循環管７８ａが配置されており、第２再循環管７８ａには、弁７９ａが配置されている。 A valve 77a is disposed on the coupler 81 side of the connection pipe 76 of the dialysate supply apparatus 900 of the present embodiment, and the upstream side of the valve 77a and the dialysate discharge pipe 80 are connected by a bypass pipe 80a. A valve 80b is disposed in the bypass pipe 80a. A second recirculation pipe 78a is arranged between the downstream side of the liquid feed pump 70 and the recirculation pipe 78, and a valve 79a is arranged in the second recirculation pipe 78a.
　以上のように構成された透析液供給装置９００の接液部の洗浄・消毒を行う方法について以下、説明する。なお、以下の説明では、洗浄剤容器２１Ｃには洗浄剤が充填されており、洗浄剤容器２１Ｄは消毒剤が充填されていることとして説明する。洗浄剤、消毒剤は、粉体でもよいし液体でもよい。まず、図３２に示すように、最初に弁７７ａ、弁８０ｂ、容器内液抜き用弁１４ｂを閉にし、ストレージ部７２０に、洗浄剤容器２１Ｃ、２１Ｄをセットする。そして、図３２に実線で示す流路Ｒ３１ａのように、水供給ポンプ１１によってＲＯ装置１２で生成したＲＯ水をタンク１５に送り、タンク１５の水位が規定水位ＨとなるまでＲＯ水をタンク１５に貯留する。タンク１５にＲＯ水を貯留したら、ストレージ部７２０を回転させて洗浄剤容器２１Ｃの中心線と第１コネクタ２６ａ、第２コネクタ２６ｂとの中心線５８０とを一致させて洗浄剤容器２１Ｃを第１コネクタ２６ａ、第２コネクタ２６ｂで挟み込み、洗浄剤容器２１Ｃ、入口管２２と、出口管２３とを連通させて１つの液体流路を形成する。本実施形態では、送液ポンプ１７０はダイヤフラム式ポンプであり、容器内液抜き用弁１４ｂが閉となっているので、洗浄剤容器２１Ｃ、入口管２２と、出口管２３とを連通させて１つの液体流路を形成しても、洗浄剤容器２１Ｃの中に充填されている液状の洗浄剤が下方に移動することはない。そして、送液ポンプ１７０を始動すると、図３３に実線で示す流路Ｒ３１ｂのように、洗浄剤容器２１Ｃの中に充填されている液状の洗浄剤が薬剤投入管１４からタンク１５に貯留されているＲＯ水の中に混合する。また、洗浄剤容器２１Ｃの中に粉状の洗浄剤が充填されている場合には、洗浄剤容器２１Ｃの中に流入したＲＯ水に粉状の洗浄剤が溶けて液状の洗浄剤となってタンク１５に貯留されているＲＯ水に混合する。この際、ＲＯ水は、第１コネクタ２６ａから第２コネクタ２６ｂに向かって洗浄剤容器２１Ｃの下側から上側に向かって流れる。そして、送液ポンプ１７０を所定の時間だけ運転すると、洗浄剤容器２１Ｃの中の洗浄剤は、タンク１５のＲＯ水に混合する。 A method for cleaning and disinfecting the wetted part of the dialysate supply apparatus 900 configured as described above will be described below. In the following description, it is assumed that the cleaning agent container 21C is filled with a cleaning agent, and the cleaning agent container 21D is filled with a disinfectant. The cleaning agent and disinfectant may be powder or liquid. First, as shown in FIG. 32, the valve 77a, the valve 80b, and the liquid draining valve 14b are first closed, and the cleaning agent containers 21C and 21D are set in the storage unit 720. 32, the RO water generated by the RO device 12 by the water supply pump 11 is sent to the tank 15 as shown by the solid line R31a in FIG. 32, and the RO water is supplied to the tank 15 until the water level of the tank 15 reaches the specified water level H. Store in. When the RO water is stored in the tank 15, the storage unit 720 is rotated so that the center line of the cleaning agent container 21C is aligned with the center line 580 of the first connector 26a and the second connector 26b. The liquid crystal is sandwiched between the connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path. In the present embodiment, the liquid feed pump 170 is a diaphragm pump, and since the liquid drain valve 14b is closed, the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated with each other. Even if one liquid flow path is formed, the liquid cleaning agent filled in the cleaning agent container 21C does not move downward. When the liquid feed pump 170 is started, the liquid cleaning agent filled in the cleaning agent container 21C is stored in the tank 15 from the medicine charging pipe 14 as shown by a flow path R31b indicated by a solid line in FIG. Mix in the RO water. When the cleaning agent container 21C is filled with a powdery cleaning agent, the powdery cleaning agent is dissolved in the RO water flowing into the cleaning agent container 21C to form a liquid cleaning agent. Mix with RO water stored in tank 15. At this time, the RO water flows from the lower side to the upper side of the cleaning agent container 21C from the first connector 26a toward the second connector 26b. When the liquid feed pump 170 is operated for a predetermined time, the cleaning agent in the cleaning agent container 21 </ b> C is mixed with the RO water in the tank 15.
　洗浄剤容器２１Ｃに充填されている洗浄剤のＲＯ水への混合が終了したら、送液ポンプ１７０を停止し、図３４に示すように容器内液抜き用弁１４ｂを開とする。すると、図３４に一点鎖線で示す流路Ｒ３１ｃに示すように、洗浄剤容器２１Ｃの中に残留している液体は、［洗浄剤容器２１Ｃ→容器内液抜き管１４ａ→タンク１５］のように、重力でタンク１５の中に移動する。洗浄剤容器２１Ｃの中の液体をタンク１５に排出したら、容器内液抜き用弁１４ｂを閉とする。 When mixing of the cleaning agent filled in the cleaning agent container 21C with the RO water is completed, the liquid feed pump 170 is stopped and the in-container draining valve 14b is opened as shown in FIG. Then, as shown in a flow path R31c indicated by a one-dot chain line in FIG. 34, the liquid remaining in the cleaning agent container 21C is as [cleaning agent container 21C → in-container drain pipe 14a → tank 15]. , Move into the tank 15 by gravity. When the liquid in the cleaning agent container 21C is discharged to the tank 15, the container draining valve 14b is closed.
　次に、第１コネクタ２６ａを上方向に、第２コネクタ２６ｂをした方向に移動させて第１、第２コネクタ２６ａ、２６ｂを洗浄剤容器２１Ｃから離間させた後、ストレージ部７２０を回転させて洗浄剤容器２１Ｄの中心線と第１コネクタ２６ａ、第２コネクタ２６ｂとの中心線５８０とを一致させる。そして、洗浄剤容器２１Ｄを第１コネクタ２６ａ、第２コネクタ２６ｂで挟み込み、洗浄剤容器２１Ｄ、入口管２２と、出口管２３を連通させて１つの液体流路とする。先に説明したと同様、本実施形態では、送液ポンプ１７０はダイヤフラム式ポンプであり、容器内液抜き用弁１４ｂが閉となっているので、洗浄剤容器２１Ｄ、入口管２２と、出口管２３とを連通させて１つの液体流路を形成しても、洗浄剤容器２１Ｄの中に充填されている消毒剤が下方に移動することはない。この後、送液ポンプ１７０を始動すると、図３３に実線で示す流路Ｒ３１ｂのように、洗浄剤容器２１Ｄの中の粉状または液状の消毒剤がタンク１５の中に混入する。送液ポンプ１７０を所定の時間運転すると、タンク１５の中には、接液部を洗浄・消毒する洗浄・消毒液が貯留される。 Next, the first connector 26a is moved upward and the second connector 26b is moved to separate the first and second connectors 26a and 26b from the cleaning agent container 21C, and then the storage unit 720 is rotated. The center line of the cleaning agent container 21D is aligned with the center line 580 of the first connector 26a and the second connector 26b. Then, the cleaning agent container 21D is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21D, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path. As described above, in this embodiment, the liquid feed pump 170 is a diaphragm pump, and the liquid draining valve 14b is closed. Therefore, the cleaning agent container 21D, the inlet pipe 22, and the outlet pipe are closed. Even if 23 is connected to form one liquid flow path, the disinfectant filled in the cleaning agent container 21D does not move downward. Thereafter, when the liquid feed pump 170 is started, the powdery or liquid disinfectant in the cleaning agent container 21D is mixed into the tank 15 as shown by a flow path R31b indicated by a solid line in FIG. When the liquid feed pump 170 is operated for a predetermined time, a cleaning / disinfecting solution for cleaning / disinfecting the liquid contact portion is stored in the tank 15.
　そして、先に説明したと同様、洗浄剤容器２１Ｄに充填されている消毒剤のＲＯ水への混合が終了したら、送液ポンプ１７０を停止し、図３４に示すように容器内液抜き用弁１４ｂを開とし、洗浄剤容器２１Ｄの中に残留している液体をタンク１５に排出させた後、容器内液抜き用弁１４ｂを閉とする。 Then, as described above, when mixing of the disinfectant filled in the cleaning agent container 21D into the RO water is completed, the liquid feed pump 170 is stopped, and the liquid draining valve as shown in FIG. 14b is opened, the liquid remaining in the cleaning agent container 21D is discharged to the tank 15, and then the liquid draining valve 14b is closed.
　タンク１５に洗浄・消毒液を貯留したら、送液ポンプ１７０を停止し、送液ポンプ７０を始動する。すると、図３５に一点鎖線で示す流路Ｒ３２ｃのように、タンク１５に貯留された洗浄・消毒液は、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→再循環管７８（弁７９）→ＲＯ水管１３（逆止弁１３ａ）→タンク１５］と循環する。図３５に示す流路Ｒ３２ｃの洗浄・消毒を所定時間行ったら、流路Ｒ３２ｃの洗浄・消毒を終了する。なお、流路Ｒ３２ｃの洗浄・消毒を行う際に、弁７９ａを開として、第２再循環管７８ａに洗浄・消毒液を流してもよい。 When the cleaning / disinfecting liquid is stored in the tank 15, the liquid feeding pump 170 is stopped and the liquid feeding pump 70 is started. 35, the cleaning / disinfecting solution stored in the tank 15 is [tank 15 → pump suction pipe 16 → feed pump 70 → heater inlet pipe 71 → heater 72 → Dialyzing fluid supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 (check valve 13a) → tank 15] circulates. When the cleaning / disinfection of the flow path R32c shown in FIG. 35 is performed for a predetermined time, the cleaning / disinfection of the flow path R32c is ended. When cleaning / disinfecting the flow path R32c, the valve 79a may be opened to allow the cleaning / disinfecting liquid to flow through the second recirculation pipe 78a.
　図３５に示す流路Ｒ３２ｃの洗浄・消毒が終了したら図３６に示すように弁８０ｂを開とし、図３６に一点鎖線で示す流路Ｒ３２ｄで示すようにタンク１５に貯留されている使用済の洗浄・消毒液を、［タンク１５→ポンプ吸込み管１６→送液ポンプ７０→ヒータ入口管７１→ヒータ７２→透析液供給管７３→バイパス管８０ａ（弁８０ｂ）→透析液排出管８０］と流してドレンから系外に排出する。なお、この際、容器内液抜き用弁１４ｂを開とし、洗浄剤容器２１Ｃまたは洗浄剤容器２１Ｄの中に残留している液体をタンク１５に排出させてもよい。 When the cleaning / disinfection of the flow path R32c shown in FIG. 35 is completed, the valve 80b is opened as shown in FIG. 36, and the used is stored in the tank 15 as shown by the flow path R32d shown by a one-dot chain line in FIG. Washing / disinfecting liquid flows through [tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → bypass pipe 80a (valve 80b) → dialysate discharge pipe 80]. Then drain it out of the system. At this time, the liquid draining valve 14b may be opened, and the liquid remaining in the cleaning agent container 21C or the cleaning agent container 21D may be discharged to the tank 15.
　本実施形態の透析液供給装置９００は、図１０から図１７を参照して説明した透析液供給装置３００と同様の効果を奏する。また、本実施形態の透析液供給装置９００は、薬剤投入機構２０をタンク１５の天井面よりも高い位置に配置しているので、洗浄剤、消毒剤をタンク１５のＲＯ水に混合した後、洗浄剤容器２１Ｃ、２１Ｄの中に残留した液体を容易にタンク１５に排出することができるという効果を奏する。なお、本実施形態では、送液ポンプ１７０は、ダイヤフラム式ポンプとして説明したが、他の形式の往復動ポンプによって構成してもよい。 The dialysate supply device 900 of the present embodiment has the same effects as the dialysate supply device 300 described with reference to FIGS. In addition, since the dialysate supply device 900 of the present embodiment has the medicine injection mechanism 20 disposed at a position higher than the ceiling surface of the tank 15, after mixing the cleaning agent and the disinfectant with the RO water in the tank 15, The liquid remaining in the cleaning agent containers 21 </ b> C and 21 </ b> D can be easily discharged to the tank 15. In the present embodiment, the liquid feed pump 170 has been described as a diaphragm pump, but may be constituted by other types of reciprocating pumps.
　次に、図３７を参照しながら、他の実施形態である透析液供給装置９１０について説明する。透析液供給装置９１０は、図３１から図３６を参照して説明した透析液供給装置９００の送液ポンプ１７０を遠心式ポンプである送液ポンプ１７０ａとし、容器内液抜き管１４ａ、容器内液抜き用弁１４ｂを設けずに、入口管２２に弁２４を配置したものである。以下の説明では、図３１から図３６を参照して説明したと同様の部分には同様の符号を付して説明は省略する。 Next, a dialysate supply apparatus 910 according to another embodiment will be described with reference to FIG. In the dialysate supply apparatus 910, the liquid feed pump 170 of the dialysate supply apparatus 900 described with reference to FIGS. 31 to 36 is a liquid feed pump 170a that is a centrifugal pump, and the in-container drain pipe 14a and the in-container liquid The valve 24 is arranged in the inlet pipe 22 without providing the extraction valve 14b. In the following description, the same parts as those described with reference to FIGS. 31 to 36 are denoted by the same reference numerals, and description thereof is omitted.
　透析液供給装置９１０では、弁２４を閉とした後、ストレージ部７２０を回転させて洗浄剤容器２１Ｃの中心線と第１コネクタ２６ａ、第２コネクタ２６ｂとの中心線５８０とを一致させて洗浄剤容器２１Ｃを第１コネクタ２６ａ、第２コネクタ２６ｂで挟み込み、洗浄剤容器２１Ｃ、入口管２２と、出口管２３とを連通させて１つの液体流路を形成する。そして、弁２４を開として送液ポンプ１７０ａを始動すると、洗浄剤容器２１Ｃの中に充填されている洗浄剤が薬剤投入管１４からタンク１５に貯留されているＲＯ水の中に混合される。洗浄剤の混合が終了したら、弁２４が開の状態で送液ポンプ１７０ａを停止する。すると、洗浄剤容器２１Ｃの中に残留している液体は、タンク１５と液面との落差により洗浄剤容器２１Ｃから弁２４、遠心式の送液ポンプ１７０ａを通って、タンク１５に移動する。次に、同様の方法で、洗浄剤容器２１Ｄに充填されている消毒剤をタンク１５に貯留されているＲＯ水に混合させた後、洗浄剤容器２１Ｄの中に残留している液体をタンク１５との液面の落差により、タンク１５に移動させる。その後、送液ポンプ７０を始動して図３５に一点鎖線で示す流路Ｒ３２ｃの洗浄・消毒を行う。そして流路Ｒ３２ｃの洗浄・消毒が終了したら、図３６に一点鎖線で示す流路Ｒ３２ｄのように、タンク１５に貯留されている使用済の洗浄・消毒液をドレンから外部に排出する。 In the dialysate supply device 910, after closing the valve 24, the storage unit 720 is rotated so that the center line of the cleaning agent container 21C is aligned with the center lines 580 of the first connector 26a and the second connector 26b. The agent container 21C is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 are communicated to form one liquid flow path. Then, when the valve 24 is opened and the liquid feed pump 170a is started, the cleaning agent filled in the cleaning agent container 21C is mixed into the RO water stored in the tank 15 from the drug introduction pipe 14. When mixing of the cleaning agent is completed, the liquid feeding pump 170a is stopped with the valve 24 being open. Then, the liquid remaining in the cleaning agent container 21C moves from the cleaning agent container 21C to the tank 15 through the valve 24 and the centrifugal liquid feed pump 170a due to a drop between the tank 15 and the liquid level. Next, after the disinfectant filled in the detergent container 21D is mixed with the RO water stored in the tank 15 by the same method, the liquid remaining in the detergent container 21D is mixed with the tank 15. Is moved to the tank 15 by the drop in the liquid level. Thereafter, the liquid feed pump 70 is started to clean and disinfect the flow path R32c indicated by a one-dot chain line in FIG. When the cleaning / disinfecting of the flow path R32c is completed, the used cleaning / disinfecting liquid stored in the tank 15 is discharged from the drain to the outside, as in the flow path R32d indicated by a one-dot chain line in FIG.
　本実施形態の透析液供給装置９１０は、図３１から図３６を参照して説明した透析液供給装置９００と同様の効果を奏する。 The dialysate supply device 910 of this embodiment has the same effect as the dialysate supply device 900 described with reference to FIGS.
　１０　水供給管、１１　水供給ポンプ、１２　ＲＯ装置、１３　ＲＯ水管、１３ａ　逆止弁、１４　薬剤投入管、１４ａ　容器内液抜き管、１５　タンク、１６　ポンプ吸込み管、２０、５５、６０、１２０　薬剤投入機構、２１　容器、２１Ａ　Ａ剤容器、２１Ｂ、４１　Ｂ剤容器、２１Ｃ、２１Ｄ、３１　洗浄剤容器、２１Ａａ、２１Ｂａ、２１Ｃａ、２１Ｄａ、３１ａ、６１ａ　上首部、２１Ａｂ、２１Ｂｂ、２１Ｃｂ、２１Ｄｂ、３１ｂ、６１ｂ　下首部、２１Ｂｃ、２１Ｂｄ、２１Ｃｃ、２１Ｃｄ、３１ｃ、３１ｄ、６１ｃ、６１ｄ　シール部材、２１Ａｅ、２１Ｂｅ、２１Ｃｅ、２１Ｄｅ、３１ｅ、６１ｅ　本体、２１Ｓ　充填状態検出センサ、２２、３２、４２、６２、１２２、１３２　入口管、２２ａ、３２ａ　第１バイパス管、２３、３３、４３、６３、１２３、１３３　出口管、２３ａ、３３ａ　第２バイパス管、１４ｂ　容器内液抜き用弁、２４、２４ａ、２５、２５ａ、３４、３４ａ、３５、３５ａ、４５、４６、４８、６４、６５、７０ａ、７０ｂ、７０ｃ、７０ｄ、７７、７７ａ、７９、７９ａ、８０ｂ、１２４、１２５、１２５ａ、１２５ｂ、１２５ｃ、１２５ｄ、１３４、１３５、１７９　弁、２６ａ、１２６ａ　第１コネクタ、２６ｂ、１２６ｂ　第２コネクタ、３０、１３０　洗浄剤投入機構、３６ａ、６６ａ、１３６ａ　上コネクタ、３６ｂ、６６ｂ、１３６ｂ　下コネクタ、４０　Ｂ剤投入機構、４４　Ｂ剤注入ポンプ、４７　バイパス管、４９ａ、４９ｂ　コネクタ、５０　Ａ剤投入機構、５１　Ａ剤タンク、５２　注入管、５３　Ａ剤注入ポンプ、６１　薬剤容器、７０、１７０、１７０ａ　送液ポンプ、７１　ヒータ入口管、７１ａ、１２３ａ　第１ポンプバイパス管、７１ｂ、１２３ｂ　第２ポンプバイパス管、７２　ヒータ、７３　透析液供給管、７４　温度センサ、７５、８３　流量センサ、７６　接続管、７８、１７８　再循環管、７８ａ　第２再循環管、８０　透析液排出管、８０ａ　バイパス管、８１、８２　カプラ、９０　ダイアライザ、９１　透析液入口、９２　透析液出口、９３　血液入口管、９４血液出口管、９５　制御部、９６　透析装置、９７ａ　透析液注入ポンプ（透析液ＩＮポンプ）、９７ｂ　透析液排出ポンプ（透析液ＯＵＴポンプ）、９７ｃ　血液ポンプ、９８　接続カプラ、１００、２００、３００、４００、８００、８５０、９００、９１０　透析液供給装置、５００　上ベース、５０１、６０１　平板、５０２、５０４、５０５、６０２、６０４、６０５　流通孔、５１３、５５３、６１３、６５３　ノズル取付け穴、５０３　上ノズル、５０６、６０６　アーム、５１０　第１嵌合ブロック、５１０ａ　第１本体、５１４、５１６、５１８、５５２、５５４、５５６、６１４、６１６、６１８、６５２、６４５、６５６　パッキン、５１５　第１嵌合穴、５１７　第２嵌合穴、５２０、６２０　空間、５５０　上嵌合ブロック、５５０ａ　上本体、５５１、６５１　フランジ、５５５　上嵌合穴、５５８、６５８　ボルト、５６０　コネクタ移動機構、５８０　中心線、６００　下ベース、６０３　下ノズル、６１０　第２嵌合ブロック、６１０ａ　第２本体、６１５　第３嵌合穴、６１７　第４嵌合穴、６５０　下嵌合ブロック、６５０ａ　下本体、６５２　パッキン、６５５　下嵌合穴、７００　上円板、７０１、７０２、７１１　丸穴、７０３、７０４　四角穴、７０５　シャフト、７０６　ボス、７０７　接続シャフト、７０８　モータ、７１０　下円板、７２０　ストレージ部、８０１、８０２、８０３　液体逆流機構。 10 water supply pipe, 11 water supply pump, 12 RO device, 13 RO water pipe, 13a check valve, 14 drug injection pipe, 14a liquid drain pipe, 15 tank, 16 pump suction pipe, 20, 55, 60, 120 Drug feeding mechanism, 21 container, 21A A agent container, 21B, 41 B agent container, 21C, 21D, 31 Detergent container, 21Aa, 21Ba, 21Ca, 21Da, 31a, 61a Upper neck, 21Ab, 21Bb, 21Cb, 21Db, 31b, 61b lower neck, 21Bc, 21Bd, 21Cc, 21Cd, 31c, 31d, 61c, 61d seal member, 21Ae, 21Be, 21Ce, 21De, 31e, 61e main body, 21S filling state detection sensor, 22, 32, 42, 62 122, 132 Inlet pipe, 22a, 32a 1st buy Pipe, 23, 33, 43, 63, 123, 133 outlet pipe, 23a, 33a second bypass pipe, 14b valve for draining liquid in container, 24, 24a, 25, 25a, 34, 34a, 35, 35a, 45 46, 48, 64, 65, 70a, 70b, 70c, 70d, 77, 77a, 79, 79a, 80b, 124, 125, 125a, 125b, 125c, 125d, 134, 135, 179 Valves, 26a, 126a 1 connector, 26b, 126b, second connector, 30, 130 cleaning agent charging mechanism, 36a, 66a, 136a upper connector, 36b, 66b, 136b lower connector, 40B agent charging mechanism, 44B agent injection pump, 47 bypass pipe, 49a, 49b connector, 50 A agent charging mechanism, 51 A agent tank, 52 injection tube, 53 Agent injection pump, 61 drug container, 70, 170, 170a liquid feed pump, 71 heater inlet pipe, 71a, 123a first pump bypass pipe, 71b, 123b second pump bypass pipe, 72 heater, 73 dialysate supply pipe, 74 Temperature sensor, 75, 83 flow sensor, 76 connecting pipe, 78, 178 recirculation pipe, 78a second recirculation pipe, 80 dialysate discharge pipe, 80a bypass pipe, 81, 82 coupler, 90 dialyzer, 91 dialysate inlet, 92 dialysate outlet, 93 blood inlet tube, 94 blood outlet tube, 95 control unit, 96 dialyzer, 97a dialysate infusion pump (dialysate IN pump), 97b dialysate discharge pump (dialysate OUT pump), 97c blood pump , 98 Connection coupler, 100, 200, 300, 400, 800, 850, 90 0, 910 dialysate supply device, 500 upper base, 501, 601 flat plate, 502, 504, 505, 602, 604, 605 flow hole, 513, 553, 613, 653 nozzle mounting hole, 503 upper nozzle, 506, 606 arm , 510 1st fitting block, 510a 1st body 514, 516, 518, 552, 554, 556, 614, 616, 618, 652, 645, 656 packing, 515 1st fitting hole, 517 2nd fitting Hole, 520, 620 space, 550 upper fitting block, 550a upper body, 551, 651 flange, 555 upper fitting hole, 558, 658 bolt, 560 connector moving mechanism, 580 center line, 600 lower base, 603 lower nozzle, 610, second fitting block, 610a, second body, 61 3rd fitting hole, 617 4th fitting hole, 650 lower fitting block, 650a lower body, 652 packing, 655 lower fitting hole, 700 upper disk, 701, 702, 711 round hole, 703, 704 square hole , 705 shaft, 706 boss, 707 connection shaft, 708 motor, 710 lower disk, 720 storage unit, 801, 802, 803 liquid backflow mechanism.

Claims (15)

  1. 　薬剤と希釈液とを混合して透析液を生成し、前記透析液を透析装置に供給する透析液供給装置であって、
    　前記透析液に接する接液部を洗浄・消毒する洗浄・消毒剤を、前記希釈液が通流する配管の中に投入する洗浄剤投入機構を備え、
    　前記洗浄剤投入機構は、前記洗浄・消毒剤を収容した洗浄剤容器と、前記洗浄剤容器の一端側の配管と、前記洗浄剤容器の他端側の配管とが連通して１つの液体流路を形成するように、一端側の配管と他端側の配管との間に前記洗浄剤容器を挟み込む透析液供給装置。     A dialysis fluid supply device that mixes a drug and a diluent to produce a dialysis fluid, and supplies the dialysis fluid to a dialysis device,
    A cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the dialysate is provided with a cleaning agent charging mechanism for introducing into the pipe through which the diluent flows.
    The cleaning agent charging mechanism is configured such that a cleaning agent container containing the cleaning / disinfecting agent, a pipe on one end side of the cleaning agent container, and a pipe on the other end side of the cleaning agent container communicate with each other. A dialysate supply apparatus that sandwiches the detergent container between a pipe on one end and a pipe on the other end so as to form a path.
  2. 　請求項１に記載の透析液供給装置であって、
    　根元側が一端側の配管に接続され、先端側が前記洗浄剤容器の一端側に突出する上首部の外周に水密に嵌り込む環状の上コネクタと、
    　前記上コネクタと同軸に配置され、根元側が他端側の配管に接続され、先端側が前記洗浄剤容器の他端側に突出する下首部の外周に水密に嵌り込む環状の下コネクタと、
    　前記上または下コネクタのいずれか一方または両方を前記洗浄剤容器の長手方向に沿って移動させるコネクタ移動機構と、を備え、
    　前記各コネクタは、その環状中心近傍に前記各首部の各端面をそれぞれシールするシール部材を貫通するノズルを備える透析液供給装置。     The dialysate supply device according to claim 1,
    An annular upper connector in which the root side is connected to the pipe on one end side, and the tip end side is fitted in a watertight manner on the outer periphery of the upper neck portion protruding to the one end side of the cleaning agent container;
    An annular lower connector that is disposed coaxially with the upper connector, the base side is connected to the pipe on the other end side, and the distal end side is watertightly fitted to the outer periphery of the lower neck portion protruding to the other end side of the cleaning agent container,
    A connector moving mechanism for moving one or both of the upper and lower connectors along the longitudinal direction of the cleaning agent container,
    Each said connector is a dialysate supply apparatus provided with the nozzle which penetrates the sealing member which each seals each end surface of each said neck part in the cyclic | annular center vicinity.
  3. 　薬剤と希釈液とを混合して透析液を生成し、前記透析液を透析装置に供給する透析液供給装置であって、
    　前記薬剤を前記希釈液が通流する配管の中に投入する薬剤投入機構を備え、
    　前記薬剤投入機構は、
    　前記薬剤を収容した薬剤容器と、前記薬剤容器の一端側の配管と、前記薬剤容器の他端側の配管とが連通して１つの液体流路を形成するように、一端側の配管と他端側の配管との間に前記薬剤容器を挟み込み可能であると共に、前記薬剤容器に代えて、前記透析液に接する接液部を洗浄・消毒する洗浄・消毒剤を収容した洗浄剤容器を一端側の配管と他端側の配管との間に挟み込み可能である透析液供給装置。     A dialysis fluid supply device that mixes a drug and a diluent to produce a dialysis fluid, and supplies the dialysis fluid to a dialysis device,
    A drug charging mechanism for charging the drug into a pipe through which the diluent flows,
    The drug injection mechanism is
    The pipe on one end side and the other side are connected so that the medicine container containing the medicine, the pipe on one end side of the medicine container, and the pipe on the other end side of the medicine container communicate with each other to form one liquid channel. The drug container can be sandwiched between an end-side pipe and a cleaning agent container containing a cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the dialysate instead of the drug container. A dialysate supply device that can be sandwiched between a pipe on the side and a pipe on the other end.
  4. 　請求項３に記載の透析液供給装置であって、
    　前記薬剤投入機構は、
    　根元側が一端側の配管に接続され、先端側が前記薬剤容器の一端側に突出する第１首部の第１外周に水密に嵌り込む第１嵌合部と、前記洗浄剤容器の一端側に突出する第２首部の第２外周に水密に嵌り込む第１嵌合部と形状の異なる第２嵌合部と、を含む環状の第１コネクタと、
    　前記第１コネクタと同軸に配置され、根元側が他端側の配管に接続され、先端側が前記薬剤容器の他端側に突出する第３首部の第３外周に水密に嵌り込む第３嵌合部と、前記洗浄剤容器の他端側に突出する第４首部の第４外周に水密に嵌り込む第３嵌合部と形状の異なる第４嵌合部と、を含む環状の第２コネクタと、
    　前記第１または第２コネクタのいずれか一方または両方を前記薬剤容器または前記洗浄剤容器の長手方向に沿って移動させるコネクタ移動機構と、を備え、
    　前記第１コネクタおよび前記第２コネクタは、その環状中心近傍に前記各首部の各端面をそれぞれシールするシール部材を貫通するノズルを備える透析液供給装置。     The dialysate supply device according to claim 3,
    The drug injection mechanism is
    A first fitting portion that is connected to a pipe on one end side and a distal end side that is watertightly fitted to a first outer periphery of a first neck portion that projects to one end side of the drug container, and a first fitting portion that projects to one end side of the cleaning agent container. An annular first connector including a first fitting portion that fits in a watertight manner on the second outer periphery of the second neck portion and a second fitting portion having a different shape;
    A third fitting portion that is disposed coaxially with the first connector, has a root side connected to the other end side pipe, and a tip end side that is watertightly fitted to the third outer periphery of the third neck portion protruding to the other end side of the drug container. And an annular second connector including a third fitting portion that fits in a watertight manner on the fourth outer periphery of the fourth neck portion protruding to the other end side of the cleaning agent container, and a fourth fitting portion having a different shape,
    A connector moving mechanism for moving either one or both of the first or second connectors along the longitudinal direction of the drug container or the cleaning agent container,
    The first connector and the second connector are dialysate supply devices each including a nozzle that penetrates a seal member that seals each end face of each neck near the annular center.
  5. 　請求項４に記載の透析液供給装置であって、
    　前記ノズルは、
    　前記洗浄剤容器の前記第４首部を前記第４嵌合部に水密に嵌め込む際に、前記洗浄剤容器の前記第４首部と前記第４嵌合部とが水密となった後に、前記第４首部の端面をシールするシール部材を前記ノズルの先端が貫通するように配置されていること、
    　を特徴とする透析液供給装置。     The dialysate supply device according to claim 4,
    The nozzle is
    When the fourth neck portion of the cleaning agent container is watertightly fitted into the fourth fitting portion, the fourth neck portion and the fourth fitting portion of the cleaning agent container become watertight, Being arranged so that the tip of the nozzle penetrates a seal member that seals the end face of the four necks;
    A dialysate supply device characterized by the above.
  6. 　請求項４に記載の透析液供給装置であって、
    　前記第１コネクタの前記第２嵌合部は、その内径が前記第１嵌合部よりも大きく、前記第１嵌合部よりも前記第１コネクタの前記先端側に配置されており、
    　前記第２コネクタの前記第４嵌合部は、その内径が前記第３嵌合部よりも大きく、前記第３嵌合部よりも前記第２コネクタの前記先端側に配置されている透析液供給装置。     The dialysate supply device according to claim 4,
    The second fitting portion of the first connector has an inner diameter larger than that of the first fitting portion, and is disposed closer to the distal end side of the first connector than the first fitting portion.
    The fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is provided on the distal end side of the second connector with respect to the third fitting portion. apparatus.
  7. 　請求項５に記載の透析液供給装置であって、
    　前記第１コネクタの前記第２嵌合部は、その内径が前記第１嵌合部よりも大きく、前記第１嵌合部よりも前記第１コネクタの前記先端側に配置されており、
    　前記第２コネクタの前記第４嵌合部は、その内径が前記第３嵌合部よりも大きく、前記第３嵌合部よりも前記第２コネクタの前記先端側に配置されている透析液供給装置。     The dialysate supply device according to claim 5,
    The second fitting portion of the first connector has an inner diameter larger than that of the first fitting portion, and is disposed closer to the distal end side of the first connector than the first fitting portion.
    The fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is provided on the distal end side of the second connector with respect to the third fitting portion. apparatus.
  8. 　請求項４に記載の透析液供給装置であって、
    　少なくとも１つの前記薬剤容器と少なくとも１つの前記洗浄剤容器とを保持するストレージ部と、
    　前記ストレージ部からいずれか１つの容器を前記第１コネクタと前記第２コネクタとの間に移送する送り機構と、を備える透析液供給装置。     The dialysate supply device according to claim 4,
    A storage unit for holding at least one drug container and at least one cleaning agent container;
    A dialysis fluid supply apparatus comprising: a feed mechanism that transfers any one container from the storage unit between the first connector and the second connector.
  9. 　請求項６に記載の透析液供給装置であって、
    　少なくとも１つの前記薬剤容器と少なくとも１つの前記洗浄剤容器とを保持するストレージ部と、
    　前記ストレージ部からいずれか１つの容器を前記第１コネクタと前記第２コネクタとの間に移送する送り機構と、を備える透析液供給装置。     The dialysate supply device according to claim 6,
    A storage unit for holding at least one drug container and at least one cleaning agent container;
    A dialysis fluid supply apparatus comprising: a feed mechanism that transfers any one container from the storage unit between the first connector and the second connector.
  10. 　請求項７に記載の透析液供給装置であって、
    　少なくとも１つの前記薬剤容器と少なくとも１つの前記洗浄剤容器とを保持するストレージ部と、
    　前記ストレージ部からいずれか１つの容器を前記第１コネクタと前記第２コネクタとの間に移送する送り機構と、を備える透析液供給装置。     The dialysate supply device according to claim 7,
    A storage unit for holding at least one drug container and at least one cleaning agent container;
    A dialysis fluid supply apparatus comprising: a feed mechanism that transfers any one container from the storage unit between the first connector and the second connector.
  11. 　請求項８に記載の透析液供給装置であって、
    　前記ストレージ部は、前記薬剤容器を保持する第１穴と、前記洗浄剤容器を保持する第１穴と形状の異なる第２穴と、を備える透析液供給装置。     The dialysate supply device according to claim 8,
    The said storage part is a dialysate supply apparatus provided with the 1st hole which hold | maintains the said chemical | medical agent container, and the 1st hole which hold | maintains the said washing | cleaning agent container, and a 2nd hole from which a shape differs.
  12. 　請求項９に記載の透析液供給装置であって、
    　前記ストレージ部は、前記薬剤容器を保持する第１穴と、前記洗浄剤容器を保持する第１穴と形状の異なる第２穴と、を備える透析液供給装置。     The dialysate supply device according to claim 9,
    The said storage part is a dialysate supply apparatus provided with the 1st hole which hold | maintains the said chemical | medical agent container, and the 1st hole which hold | maintains the said washing | cleaning agent container, and a 2nd hole from which a shape differs.
  13. 　請求項１０に記載の透析液供給装置であって、
    　前記ストレージ部は、前記薬剤容器を保持する第１穴と、前記洗浄剤容器を保持する第１穴と形状の異なる第２穴と、を備える透析液供給装置。     The dialysate supply device according to claim 10,
    The said storage part is a dialysate supply apparatus provided with the 1st hole which hold | maintains the said chemical | medical agent container, and the 1st hole which hold | maintains the said washing | cleaning agent container, and a 2nd hole from which a shape differs.
  14. 　請求項３に記載の透析液供給装置であって、
    　前記薬剤容器または前記洗浄剤容器に取り付けられて前記薬剤容器または前記洗浄剤容器の充填状態を検出する充填状態検出センサと、
    　前記充填状態検出センサからの信号が入力される制御部と、を備え、
    　前記制御部は、前記充填状態検出センサからの信号に基づいて前記薬剤容器または前記洗浄剤容器が空かどうかを判定すること、
    　を特徴とする透析液供給装置。     The dialysate supply device according to claim 3,
    A filling state detection sensor which is attached to the medicine container or the cleaning agent container and detects a filling state of the medicine container or the cleaning agent container;
    A control unit to which a signal from the filling state detection sensor is input,
    The controller determines whether the medicine container or the cleaning agent container is empty based on a signal from the filling state detection sensor;
    A dialysate supply device characterized by the above.
  15. 　請求項３に記載の透析液供給装置であって、
    　液体を前記洗浄剤容器の他端側から一端側に逆流させる液体逆流機構を有すること、
    　を特徴とする透析液供給装置。     The dialysate supply device according to claim 3,
    Having a liquid backflow mechanism for backflowing liquid from the other end side of the cleaning agent container to one end side;
    A dialysate supply device characterized by the above.
PCT/JP2016/078702 2015-09-29 2016-09-28 Dialysate supply device WO2017057503A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-191789 2015-09-29
JP2015191789A JP2018201532A (en) 2015-09-29 2015-09-29 Dialysis liquid supply device

Publications (1)

Publication Number Publication Date
WO2017057503A1 true WO2017057503A1 (en) 2017-04-06

Family

ID=58423840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/078702 WO2017057503A1 (en) 2015-09-29 2016-09-28 Dialysate supply device

Country Status (2)

Country Link
JP (1) JP2018201532A (en)
WO (1) WO2017057503A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06125983A (en) * 1990-05-25 1994-05-10 Gambro Lundia Ab System controls medical treating device
JP2753242B2 (en) * 1987-02-06 1998-05-18 ガンブロ アクチーボラグ System for preparing a medical solution by mixing a concentrate in powder form with water, cartridge suitable for treatment by the system and method of making the cartridge
JPH11508469A (en) * 1995-07-03 1999-07-27 アルティン メディカル アクティエボラーグ Equipment for dialysis machine
JP2002331030A (en) * 2001-05-08 2002-11-19 Nextier:Kk Dialysate circulation instrument and cleaning method therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2753242B2 (en) * 1987-02-06 1998-05-18 ガンブロ アクチーボラグ System for preparing a medical solution by mixing a concentrate in powder form with water, cartridge suitable for treatment by the system and method of making the cartridge
JPH06125983A (en) * 1990-05-25 1994-05-10 Gambro Lundia Ab System controls medical treating device
JPH11508469A (en) * 1995-07-03 1999-07-27 アルティン メディカル アクティエボラーグ Equipment for dialysis machine
JP2002331030A (en) * 2001-05-08 2002-11-19 Nextier:Kk Dialysate circulation instrument and cleaning method therefor

Also Published As

Publication number Publication date
JP2018201532A (en) 2018-12-27

Similar Documents

Publication Publication Date Title
JP6549211B2 (en) Control architecture and method of blood treatment system
JP6728069B2 (en) Methods for treating dialysate, dialysis systems, and methods for pre-evaluating dialysis patients for treatment with the dialysis systems
US9895479B2 (en) Water management system for use in dialysis
US10052624B2 (en) Zirconium phosphate and zirconium oxide recharging flow paths
US4789467A (en) Automated disinfection system
US5484397A (en) Artificial kidney for frequent (daily) hemodialysis
JP5369140B2 (en) Mixing equipment
JPH07184993A (en) Blood dialyser
CN107847659B (en) Dialysis priming procedure using infusion cassettes
GB2310602A (en) Modular home dialysis system
CN103687937A (en) Systems, methods and control laws for cell harvesting
EP3302610B1 (en) Zirconium phosphate and zirconium oxide recharging flow paths
EP3302609A1 (en) Recharger for recharging zirconium phosphate and zirconium oxide modules
CN116685364A (en) Dialysis system and method
US20150343105A1 (en) Cleaning/disinfecting method using endoscope cleaning/disinfecting apparatus
WO2017057503A1 (en) Dialysate supply device
JP2007190068A (en) Blood purifying apparatus and automatic priming method of its blood circulation path
JP2010029376A (en) Dialyzer
CN115192744B (en) Liquid adding and transferring device for low-temperature plasma sterilizer
JP7442715B2 (en) blood purification device
CN213554253U (en) Liquid shunting device
JP2019022587A (en) Dialysis fluid generating system
EP0648508B1 (en) Servicing apparatus for dialysis machine
WO2021112245A1 (en) Dialysate solution supplying apparatus
EP4094785A1 (en) Integrated filter in cassette system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16851674

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16851674

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP