JP2018201532A - Dialysis liquid supply device - Google Patents

Abstract

To provide a dialysis liquid supply device enabling an operator to perform easily a washing/sterilization work of a liquid flow path with a simple constitution.SOLUTION: A dialysis liquid supply device includes a washing agent makeup mechanism 30 for making up a washing/sterilization agent for washing/sterilizing a liquid contact part having a contat with dialysis liquid of the dialysis liquid supply device 100, into an RO water pipe 13 through which diluted solution is circulated. The washing agent makeup mechanism 30 sandwiches a washing agent container 31 between an inlet pipe 32 and an outlet pipe 33 so that one liquid passage is formed by communication between the washing agent container 31 for storing the washing/sterilization agent, the inlet pipe 32 of the washing agent container 31, and the outlet pipe 33 of the washing agent container 31.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a structure of a dialysate supply device.

  2. Description of the Related Art Conventionally, a dialysate supply device that mixes a plurality of drugs and a diluent (for example, water) to generate a dialysate and supplies the dialysate to a dialyzer has been used. As such a dialysate supply device, a predetermined amount of water is introduced into a bag containing two kinds of powdered medicines to dissolve the powder in the bag to generate a dialysate, and then the dialysate is put into a container. A device that stores the dialysis fluid stored in the container and sucks it with a suction tube and supplies it to the dialysis circuit (see, for example, Patent Document 1) or a cartridge containing a medicine is mounted on the holder of the device. What is used is to inject metered water into a dialysate having a predetermined concentration (for example, see Patent Document 2).

  Such a liquid flow path of the dialysate supply device needs to be cleaned and disinfected with a cleaning / disinfectant such as a sodium hypochlorite solution or an acetic acid-based solution after completion of dialysis. For example, in the apparatus described in Patent Document 1, after the inside of the apparatus is emptied, a sterilizing agent is put into a container, and the sterilizing agent is circulated through the entire system by a pump to clean the liquid flow path. . Moreover, in the dialysate supply apparatus as described in Patent Document 2, the cleaning / disinfecting agent in the chemical solution bottle is injected into the pipe from the chemical solution bottle using the chemical solution suction line and the chemical solution suction pump, thereby bypassing the drug cartridge. In many cases, a cleaning / disinfectant is circulated in the liquid flow path using piping to clean the liquid flow path.

Japanese Patent No. 5352453 Japanese Patent No. 3848371

  By the way, in the dialysate supply apparatus as described in Patent Documents 1 and 2, it is necessary to transfer the stock solution or the cleaning / disinfectant having a specified concentration from a separate container to a container in the apparatus or a chemical solution bottle. At this time, the operator needs to work carefully so as not to come into contact with the cleaning / disinfecting agent, and there is a problem that it takes time and effort to clean and disinfect the apparatus. In addition, dedicated piping and valves for injecting the cleaning / disinfectant are required, which complicates the apparatus.

  SUMMARY OF THE INVENTION An object of the present invention is to provide a dialysate supply apparatus that allows an operator to easily perform cleaning and disinfection of a liquid flow path with a simple configuration.

  The dialysate supply device of the present invention is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer, the dialysate supply device of the dialysate supply device A cleaning / disinfecting mechanism for supplying cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the pipe into the pipe through which the diluent flows, and the cleaning agent charging mechanism contains the cleaning / disinfecting agent The one end side pipe and the one end side pipe so that the one end side pipe of the cleaning agent container and the other end side pipe of the cleaning agent container communicate with each other to form one liquid flow path. The cleaning agent container is sandwiched between the pipe on the other end side.

  In the dialysate supply device of the present invention, an annular upper connector whose root side is connected to the pipe on the one end side and whose tip side is watertightly fitted to the outer periphery of the upper neck portion protruding to one end side of the cleaning agent container, and the upper connector And an annular lower connector that has a root side connected to the pipe on the other end side, and a tip end side that fits water tightly on the outer periphery of the lower neck protruding to the other end side of the cleaning agent container, and the upper or lower A connector moving mechanism that moves either one or both of the connectors along the longitudinal direction of the cleaning agent container, and each connector seals each end face of each neck near its annular center. It is also preferable to provide a nozzle that passes through the nozzle.

  The dialysate supply device according to the present invention is a dialysate supply device that mixes a drug and a diluent to generate a dialysate, and supplies the dialysate to the dialyzer. And a medicine container that houses the medicine, a pipe on one end side of the medicine container, and a pipe on the other end side of the medicine container. The drug container can be sandwiched between the one end side pipe and the other end side pipe so as to form one liquid flow path, and the dialysate supply is provided instead of the drug container. A cleaning agent container containing a cleaning / disinfecting agent for cleaning / disinfecting a wetted part in contact with the dialysate of the apparatus can be sandwiched between the one end side piping and the other end side piping. To do.

  In the dialysis fluid supply device of the present invention, the drug injection mechanism is configured such that a root side is connected to the pipe on the one end side, and a tip end side is fitted in a watertight manner on the first outer periphery of the first neck part protruding to the one end side of the drug container. An annular first including a first fitting portion and a second fitting portion having a different shape from a first fitting portion that is watertightly fitted to the second outer periphery of the second neck portion that protrudes toward one end of the cleaning agent container. The connector is disposed coaxially with the first connector, the root side is connected to the pipe on the other end side, and the tip end side is fitted into the third outer periphery of the third neck portion protruding to the other end side of the drug container. An annular first including a third fitting portion, and a fourth fitting portion having a different shape from a third fitting portion fitted in a watertight manner on the fourth outer periphery of the fourth neck portion protruding to the other end side of the cleaning agent container. 2 connectors and either one or both of the first or second connector and the drug container or front A connector moving mechanism for moving along the longitudinal direction of the cleaning agent container, wherein the first and second connectors have nozzles penetrating seal members for sealing the respective end faces of the neck portions in the vicinity of the annular center. It is also suitable as providing.

  In the dialysate supply device according to the present invention, the inner diameter of the second fitting portion of the first connector is larger than that of the first fitting portion, and the tip of the first connector is larger than the first fitting portion. The fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is closer to the distal end side of the second connector than the third fitting portion. It is also suitable as being arranged.

  In the dialysate supply device of the present invention, a storage unit holding at least one drug container and at least one cleaning agent container, and any one container from the storage unit is connected to the first connector and the second connector. And a feeding mechanism for transporting between them.

  In the dialysate supply device according to the present invention, the storage unit may include a first hole for holding the drug container and a second hole having a different shape from the first hole for holding the cleaning agent container. It is.

  The present invention can provide a dialysate supply apparatus that allows an operator to easily clean and disinfect a liquid flow path with a simple configuration.

It is a systematic diagram which shows the structure of the dialysate supply apparatus in embodiment of this invention. It is sectional drawing which shows the washing | cleaning agent container and chemical | medical agent container which are used for the dialysate supply apparatus in embodiment of this invention. It is sectional drawing which shows the structure of the cleaning agent injection | throwing-in mechanism of the dialysate supply apparatus shown in FIG. It is sectional drawing which shows the state which attached the cleaning agent container to the cleaning agent injection | throwing-in mechanism shown in FIG. FIG. 4 is a view showing a flow of a cleaning / disinfecting liquid when a cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and a wetted part of the dialysate supply apparatus shown in FIG. FIG. 4 is a view showing another flow of the cleaning / disinfecting liquid when the cleaning agent container is attached to the cleaning agent charging mechanism shown in FIG. 3 and the liquid contact portion of the dialysate supply device shown in FIG. 1 is cleaned. It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this invention. It is a figure which shows the flow of the washing | cleaning and disinfection liquid at the time of attaching a washing | cleaning agent container to the washing | cleaning agent injection | throwing-in mechanism shown in FIG. 7, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container to the washing | cleaning agent injection | throwing-in mechanism shown in FIG. 7, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this invention. It is sectional drawing which shows the structure of the chemical | medical agent injection | throwing-in mechanism of the dialysate supply apparatus shown in FIG. It is a top view which shows the upper disc of the storage part of the chemical | medical agent injection | throwing-in mechanism shown in FIG. It is a top view which shows the lower disc of the storage part of the chemical | medical agent injection | throwing-in mechanism shown in FIG. It is sectional drawing which shows the structure of the 1st, 2nd connector of the chemical | medical agent injection | throwing-in mechanism shown in FIG. It is sectional drawing which shows the state which attached the chemical | medical agent container to the 1st, 2nd connector shown in FIG. It is sectional drawing which shows the state which attached the cleaning agent container to the 1st, 2nd connector shown in FIG. It is a figure which shows the flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container between the 1st, 2nd connectors shown in FIG. 15, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning agent container between the 1st, 2nd connectors shown in FIG. 15, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. It is a systematic diagram which shows the structure of the other dialysate supply apparatus in embodiment of this invention. It is a figure which shows the flow of the washing | cleaning and disinfection liquid at the time of attaching a cleaning agent container to a chemical | medical agent injection | throwing-in mechanism, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG. It is a figure which shows the other flow of the washing | cleaning / disinfecting liquid at the time of attaching a washing | cleaning container to a chemical | medical agent injection | throwing-in mechanism, and wash | cleaning the liquid-contact part of the dialysate supply apparatus shown in FIG.

  Hereinafter, the dialysate supply apparatus 100 according to an embodiment of the present invention will be described with reference to the drawings. The dialysate supply device 100 is a batch-type dialysate supply device that generates and stores a predetermined concentration of dialysate in the tank 15 and supplies the stored dialysate to the dialyzer 96. As shown in FIG. 1, the dialysate supply device 100 generates high-purity RO water using a water supply pump 11 that supplies water from a water supply source such as tap water, a reverse osmosis membrane (RO membrane), and the like. RO device 12 for performing the treatment, a drug feeding mechanism 60 for feeding a drug for generating dialysate into RO water as a diluent, and a cleaning / disinfecting agent for cleaning / disinfecting the wetted part in contact with the dialysate The cleaning agent charging mechanism 30 to be charged therein, the tank 15 for storing the generated dialysate, the liquid feed pump 70 for sending the dialysate in the tank 15 to the dialyzer 96, and the dialysate to be sent to the dialyzer 96 are heated. A heater 72, pipes, valves, temperature sensors 74, flow sensors 75, 83 for connecting the devices, and couplers 81, 82 connected to the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 96, respectively. It is out. Between the dialyzer 90 and the dialysate inlet 91, a dialysate injection pump 97a (dialysate IN pump) for injecting dialysate into the dialyzer 90 of the dialyzer 96 is disposed. Is provided with a dialysate discharge pump 97b (dialyte OUT pump) for discharging dialysate from the dialyzer 90. The blood of the patient flows from the artery through the blood inlet tube 93 to the blood inlet of the dialyzer 90 by the blood pump 97c, and returns to the patient's vein from the blood outlet tube 94 of the dialyzer 90.

  As shown in FIG. 1, the water supply pump 11 and the RO device 12 are connected by a water supply pipe 10, and the RO device 12, the drug charging mechanism 60, and the cleaning agent charging mechanism 30 are connected by an RO water pipe 13, The mechanism 60, the cleaning agent charging mechanism 30 and the tank 15 are connected by a chemical charging pipe 14. The tank 15 and the liquid feeding pump 70 are connected by a pump suction pipe 16. The liquid feeding pump 70 and the heater 72 are heaters. Connected by an inlet pipe 71, the heater 72 and the valve 77 are connected by a dialysate supply pipe 73, and the valve 77 and the coupler 81 are connected by a connecting pipe 76. A dialysate discharge pipe 80 is connected to the coupler 82. The dialysate supply pipe 73 and the RO water pipe 13 are connected by a recirculation pipe 78, and a valve 79 is disposed in the recirculation pipe 78. The dialysate supply pipe 73 is provided with a temperature sensor 74 and a flow rate sensor 75 for detecting the temperature and flow rate of the dialysate supplied to the dialyzer 96. The dialysate discharge pipe 80 is discharged from the dialyzer 96. A flow sensor 83 for detecting the flow rate of the dialysate is attached. Further, in the dialysate supply apparatus 100 of the present embodiment, as indicated by a broken line in FIG. 1 as an option, another detergent charging mechanism 130 is disposed in the dialysate discharge pipe 80, and the dialysate discharge pipe 80 and The RO water pipe 13 is connected by another recirculation pipe 178, and a valve 179 is disposed in the recirculation pipe 178.

  The drug injection mechanism 60 includes an inlet pipe 62 into which RO water as a diluent is introduced, an upper connector 66 a whose root is connected to the inlet pipe 62 and the tip fits into one end of the drug container 61, and the drug injection pipe 14. An outlet pipe 63 connected to the bottom, a lower connector 66b having a root connected to the outlet pipe 63 and a tip fitted into the other end of the drug container 61, a valve 64 disposed on the inlet pipe 62 and the outlet pipe 63, respectively. 65. Further, the cleaning agent charging mechanism 30 includes an inlet pipe 32 into which RO water as a diluent is introduced, an upper connector 36a whose root is connected to the inlet pipe 62 and the tip is fitted into one end of the cleaning agent container 31, The outlet pipe 33 connected to the medicine injection pipe 14, the lower connector 36 b whose root is connected to the outlet pipe 33 and the tip fits into the other end of the cleaning agent container 31, the inlet pipe 32, and the outlet pipe 33 are arranged. It is comprised by the valves 34 and 35 to be performed.

  When a bicarbonate dialysate is used as the dialysate, the dialysate is generated by mixing and diluting two agents, agent A and agent B. Here, the agent A is an agent containing an electrolyte component (for example, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate), a pH adjuster (for example, acetic acid), a sugar (for example, glucose) and the like. Moreover, B agent is a chemical | medical agent containing sodium bicarbonate etc. The medicine input mechanism 60 can attach a medicine container 61 filled with an amount of the agent A or agent B necessary for generating a single dialysate between the connectors 66a and 66b. The A agent and the B agent may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent. As the cleaning / disinfecting agent, a sodium hypochlorite solution or an acetic acid solution is used. The cleaning agent charging mechanism 30 can attach a cleaning agent container 31 filled with a cleaning agent or a disinfectant necessary for one cleaning / disinfection between the connectors 36a and 36b. These cleaning / disinfecting agents may be in a powder state or a tablet state, or may be in a concentrated liquid state dissolved with a small amount of diluent.

  As shown in FIG. 2, the cleaning agent container 31 is a cylinder or a square tube, and includes a main body 31e for storing the cleaning / disinfecting agent, a cylindrical upper neck portion 31a protruding upward, and a cylinder protruding downward. And a lower neck portion 31b of the shape. The opening at the upper end of the upper neck portion 31a and the opening at the lower end of the lower neck portion 31b are sealed by sheet-like sealing materials 31c and 31d, respectively. The size of the main body 31e can be appropriately changed according to the type of cleaning / disinfecting agent and the amount required for one cleaning / disinfecting. The drug container 61 has the same shape as the cleaning agent container 31, but the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the upper and lower neck portions 31a and 31b are as shown in FIG. It is different from the outer diameter. In addition, the size of the main body 61e is changed depending on the type of medicine and the amount required for one generation of dialysate.

  The water supply pump 11, the liquid feed pump 70, the cleaning agent charging mechanism 30, the chemical charging mechanism 60, the heater 72, and the valves 77, 79, and 179 are connected to the control unit 95 and are driven or opened / closed according to commands from the control unit 95. . Further, detection signals from the temperature sensor 74 and the flow sensors 75 and 83 are input to the control unit 95. The control unit 95 is a computer that includes a CPU that performs information processing and a storage unit that stores control programs and data.

  Next, the detailed structure of the cleaning agent charging mechanism 30 will be described with reference to FIG. As shown in FIG. 3, the cleaning agent charging mechanism 30 includes an upper connector 36a, a lower connector 36b arranged coaxially with the upper connector 36a, a connector moving mechanism 560 that drives the connectors 36a and 36b in the vertical direction, An inlet pipe 32, an outlet pipe 33, a valve 34 disposed in the inlet pipe 32, and a valve 35 disposed in the outlet pipe 33 are included. The upper connector 36 a includes an upper base 500 and an upper fitting block 550 that is fixed to the lower surface of the upper base 500 with bolts 558. Further, the lower connector 36b includes a lower base 600 and a lower fitting block 650 that is fixed to the upper surface of the lower base 600 with bolts 658.

  The upper base 500 of the upper connector 36a includes a metal flat plate 501 and an upper nozzle 503 protruding downward from the center of the lower surface of the flat plate 501. The flat plate 501 is connected to the connector moving mechanism 560 by an arm 506. In addition, a flow hole 502 for introducing RO water that is a diluent is provided inside the flat plate 501. The circulation hole 502 extends to the side surface of the flat plate 501 and opens, and the inlet pipe 32 is connected to the opening. The upper nozzle 503 has a rod shape with a sharp tip, and a flow hole 504 extending in the axial direction is provided in the center portion so as to communicate with the flow hole 502 of the flat plate 501. In addition, a flow hole 505 that communicates with the flow hole 504 and extends in the radial direction and opens to the outer surface of the upper nozzle 503 is provided at the tip portion of the upper nozzle 503.

  The upper fitting block 550 of the upper connector 36a includes a flange 551 fixed to the flat plate 501 of the upper base 500 with a bolt 558, and an upper body 550a extending downward from the center of the flange 551. The upper main body 550a has an annular shape and is provided with a circular two-stage hole in the center. A nozzle mounting hole 553 having the same diameter as the outer diameter of the upper nozzle 503 is provided on the upper base 500 side of the upper main body 550a, and an annular upper neck portion of the cleaning agent container 31 as shown in FIG. An upper fitting hole 555 for fitting 31a is provided. The inner diameter of the upper fitting hole 555 is substantially the same as the outer diameter of the upper neck portion 31a. A packing 554 is attached to the inner surface of the nozzle mounting hole 553 for watertight sealing with the outer surface of the upper nozzle 503. Similarly, a packing 556 is also provided on the inner surface of the upper fitting hole 555 for watertight sealing between the cleaning container 31 and the upper neck portion 31a. The upper fitting hole 555 and the packing 556 constitute an upper fitting portion. Further, a packing 552 is also provided on a surface connected to the flat plate 501 of the upper base 500 of the upper fitting block 550.

  The lower base 600 of the lower connector 36b includes a metal flat plate 601 and a lower nozzle 603 protruding upward from the center of the upper surface of the flat plate 601. The flat plate 601 is connected to the connector moving mechanism 560 by an arm 606. The lower nozzle 603 is shaped like a cylinder cut diagonally, has a sharp tip, a flow hole 605 having a large inner diameter is provided on the tip side, and communicates with the flow hole 605 on the lower base 600 side. A flow hole 604 extending in the axial direction is provided. A flow hole 602 that communicates with the flow hole 604 of the lower nozzle 603 is provided inside the flat plate 601. The circulation hole 602 extends to the side surface of the flat plate 601 and is opened, and the outlet pipe 33 is connected to the opening. As shown in FIG. 4, the cleaning / disinfecting agent filled in the cleaning agent container 31 attached between the upper connector 36a and the lower connector 36b, and the RO introduced into the cleaning agent container 31 from the upper connector 36a. Water flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 and the flow holes 602 of the lower base 600.

  The lower fitting block 650 of the lower connector 36b has substantially the same configuration as the upper fitting block 550, and includes a flange 651 and a lower main body 650a extending upward from the center of the flange 651. The lower main body 650a has an annular shape and is provided with a circular two-stage hole in the center. A nozzle mounting hole 653 having a diameter the same as the outer diameter of the lower nozzle 603 is provided on the lower base 600 side of the lower main body 650a, and an annular lower neck portion of the cleaning agent container 31 as shown in FIG. A lower fitting hole 655 for fitting 31b is provided. The inner diameter of the lower fitting hole 655 is substantially the same as the outer diameter of the lower neck portion 31b. A packing 654 is attached to the inner surface of the nozzle mounting hole 653 for watertight sealing with the outer surface of the lower nozzle 603. Similarly, a packing 656 is provided on the inner surface of the lower fitting hole 655 to seal the space between the lower neck portion 31b of the cleaning agent container 31 in a watertight manner. Lower fitting hole 655 and packing 656 constitute a lower fitting portion. A packing 652 is also provided on the surface of the lower base 600 that is connected to the flat plate 601 of the lower fitting block 650.

  As shown in FIG. 3, the center of the two-step hole of the upper fitting block 550 of the upper connector 36a, that is, the center of the nozzle mounting hole 553 and the upper fitting hole 555, and the two of the lower fitting block 650 of the lower connector 36b. The center of the step hole, that is, the center of the nozzle mounting hole 653 and the lower fitting hole 655 is disposed on the same center line 580. Accordingly, the upper and lower fitting holes 555 and 655 are arranged coaxially. In the present embodiment, the centers of the upper nozzle 503 and the lower nozzle 603 are also arranged on the center line 580 and are coaxially arranged.

  The connector moving mechanism 560 is connected to the control unit 95 and moves either one or both of the upper connector 36a and the lower connector 36b in the vertical direction according to a command from the control unit 95 or an operation of the operator.

  The medicine charging mechanism 60 has the same structure as the cleaning agent charging mechanism 30 described above, and includes an upper connector 66a, a lower connector 66b arranged coaxially with the upper connector 66a, and connector movement for driving each connector in the vertical direction. It includes a mechanism 560, an inlet pipe 62, an outlet pipe 63, a valve 64 disposed in the inlet pipe 62, and a valve 65 disposed in the outlet pipe 63. The inner diameters of the upper fitting hole 555 of the upper connector 66a and the lower fitting hole 655 of the lower connector 66b are substantially the same as the outer diameters of the upper neck portion 61a and the lower neck portion 61b of the drug container 61 shown in FIG. .

  Next, a method for cleaning and disinfecting the liquid contact portion of the dialysate supply device 100 by attaching the cleaning agent container 31 to the cleaning agent charging mechanism 30 will be described with reference to FIGS. First, the cleaning agent container 31 is attached to the cleaning agent charging mechanism 30 with the valves 34, 35, 64, and 65 shown in FIG. Further, the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98. The coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.

  In order to attach the cleaning agent container 31 between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30, the upper connector 36a is moved upward and the lower connector 36b is moved downward by the connector moving mechanism 560. After the interval between the tip of 503 and the tip of the lower nozzle 603 is made longer than the overall length in the vertical direction of the cleaning agent container 31, the centers of the upper neck portion 31 a and the lower neck portion 31 b of the cleaning agent container 31 are positioned at the center line 580. In the state where the cleaning agent container 31 is held, the lower connector 36b is moved upward and the upper connector 36a is moved downward. Then, the lower connector 36b breaks the sealing material 31d at the sharp tip of the lower nozzle 603 and enters the cleaning agent container 31, and the lower fitting hole 655 fits into the outer periphery of the lower neck portion 31b. And the packing 656 of the lower fitting hole 655 adheres to the outer periphery of the lower neck part 31b. Similarly, the upper connector 36a breaks the sealing material 31c at the sharp tip of the upper nozzle 503 and enters the cleaning agent container 31, and the upper fitting hole 555 fits into the outer periphery of the upper neck portion 31a. And the packing 556 of the upper fitting hole 555 adheres to the outer periphery of the upper neck part 31a. As a result, as shown in FIG. 4, the cleaning agent container 31 is sandwiched between the upper connector 36a and the lower connector 36b, and the cleaning agent container 31, the inlet pipe 32, and the outlet pipe 33 communicate with each other. One liquid flow path is formed.

  When the cleaning agent container 31 is attached between the upper connector 36a and the lower connector 36b, the valve 34 arranged in the inlet pipe 32 and the valve 35 arranged in the outlet pipe 33 are opened as shown in FIG. And Then, as shown by the arrow in FIG. 4, RO water flows from the inlet pipe 32 into the flow hole 502 of the flat plate 501 of the upper connector 36a. The RO water that has flowed into the flow hole 502 flows into the cleaning agent container 31 from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503. When the cleaning / disinfecting agent filled in the cleaning agent container 31 is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 31 to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 33 through the flow holes 605 and 604 of the lower nozzle 603 through the flow holes 602 of the flat plate 601. And it flows in into the tank 15 through the chemical | medical agent injection pipe | tube 14, as shown to flow path R11 of FIG. The water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.

  Next, when the valves 77 and 179 are closed and the valve 79 is opened and the liquid feed pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R12 indicated by a one-dot chain line in FIG. [Tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → cleaner injection mechanism 30 → chemical supply Tube 14 → tank 15] is circulated, and the wetted parts of each device and pipe are cleaned and disinfected. When the cleaning and disinfection of the flow path R12 shown in FIG. 5 is performed for a predetermined time, the cleaning and disinfection of the flow path R12 is finished.

  When the cleaning / disinfection of the flow path R12 is completed, the valve 79 is closed and the valve 77 is opened as shown in FIG. Then, the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate as shown in the flow path R13 of FIG. Supply pipe 73 → valve 77 → connection pipe 76 → coupler 81 → connection coupler 98 → coupler 82 → dialysate discharge pipe 80] and the flow drain are discharged out of the system. When all of the cleaning / disinfecting liquid stored in the tank 15 is discharged from the drain through the flow path R13, the primary cleaning of the liquid contact portion of the dialysate supply device 100 is finished.

  Next, the cleaning agent container 131 is attached to the other cleaning agent charging mechanism 130 in the same procedure as that for attaching the cleaning agent container 31 to the cleaning agent charging mechanism 30, and the water supply pump 11 removes the RO device 12 from the RO device 12. A predetermined amount of RO water is stored in the tank 15, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, and the RO water is introduced from the tank 15 into the cleaning agent container 131 by the liquid feed pump 70, and the cleaning / disinfecting solution is allowed to flow. As shown in path R14, [detergent injection mechanism 130 → dialysate discharge pipe 80 → recirculation pipe 178 (valve 179) → RO water pipe 13 → cleaner injection mechanism 30 → drug injection pipe 14 → tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → valve 77 → connecting pipe 76 → coupler 81 → connecting coupler 98 → coupler 82 → cleaning agent charging mechanism 130] Performing secondary cleaning by ring. When the flow path R14 shown in FIG. 6 is cleaned and disinfected for a predetermined time, the secondary cleaning ends. When the secondary cleaning is completed, the valve 179 is closed and the cleaning / disinfecting liquid remaining in the tank 15 is discharged from the drain to the outside through the flow path R13.

  Thereafter, the RO water is introduced into the system by the water supply pump 11 and circulated through the flow path R12 shown in FIG. 5 or the flow path R14 shown in FIG. Flushing for discharging the RO water accumulated in the tank 15 from the drain to the outside of the system by the path R13 is performed, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 100 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.

  As described above, in the dialysate supply device 100 according to the present embodiment, the upper container 36a and the lower connector 36b of the cleaning agent charging mechanism 30 are provided with the cleaning agent container 31 filled and sealed by the operator with a predetermined amount of cleaning / disinfecting agent. The liquid contact part of the dialysate supply device 100 can be cleaned and disinfected by simply setting the gap between the liquid channel and the operator so that the liquid flow path can be easily cleaned and disinfected without touching the cleaning / disinfectant. It can be carried out. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.

  When the dialysate is supplied to the dialyzer 96 by the dialysate supply device 100, the drug container 61 is attached to the drug input mechanism 60 in the same manner as the cleaning agent container 31 is attached to the cleaning agent input mechanism 30. RO water is introduced into the drug container 61 to dissolve the drug to obtain a high-concentration dialysate, and flows into the tank 15 from the drug input tube 14. Then, RO water is caused to flow into the tank 15 until a predetermined concentration is reached, and a dialysate having a predetermined concentration is generated and stored in the tank 15. Then, the dialysate having a predetermined concentration stored in the tank 15 is supplied to the dialyzer 96 by the liquid feed pump 70.

  Next, a dialysate supply apparatus 200 according to another embodiment will be described with reference to FIGS. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted.

  The dialysate supply apparatus 200 shown in FIG. 7 generates and stores a predetermined concentration of dialysate in the tank 15 as described with reference to FIGS. 1 to 6, and supplies the stored dialysate to the dialyzer 96. Unlike the dialysate supply device 100 of the type, high concentration A agent and B agent are continuously added little by little into the RO water pipe 13 to generate a predetermined concentration of dialysate and supply it to the dialyzer 96. is there. In the dialysate supply device 200 of the embodiment, the cleaning agent charging mechanism 30 is disposed so as to bypass the RO water pipe 13, and a valve 37 is disposed in the RO water pipe 13 parallel to the cleaning agent charging mechanism 30. The configuration of the cleaning agent charging mechanism 30 is the same as that described above with reference to FIGS. As in the above-described embodiment, the dialysate supply apparatus 200 according to this embodiment includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13. Another recirculation pipe 178 and a valve 179 are provided.

  As shown in FIG. 7, the medicine charging mechanism 55 includes a B agent charging mechanism 40 and an A agent charging mechanism 50. The B agent charging mechanism 40 connects the upper and lower sides of the B agent container 41 filled with the B agent (powder agent) to the connectors 49a and 49b, and is arranged in the inlet pipe 42, the outlet pipe 43 and the inlet pipe 42. A B agent injection pump 44, a valve 46, a bypass pipe 47 and a valve 48 disposed in the valve 45 and the outlet pipe 43 are included. The structures of the connectors 49a and 49b are the same as those described with reference to FIGS. 3 and 4, but the flow paths provided in the connectors 49a and 49b of the B agent container 41 (shown in FIGS. 3 and 4). A flow path closing mechanism capable of closing the flow holes 502 or 504, 602 or 604) is attached. In order to inject a high concentration of B agent into the RO water pipe 13 by the B agent charging mechanism 40, the valves 45 and 46 are opened, a predetermined amount of RO water is introduced into the B agent container 41, and the B agent container 41 A B agent solution having a saturated concentration is generated in the RO water pipe 13 by a B agent injection pump 44 little by little. The agent A charging mechanism 50 includes an agent A tank 51 containing a high-concentration solution of agent A, an agent A injection pump 53, an injection pipe 52 and a valve 54, and injects agent A. Opens the valve 54, sucks up the solution of the agent A from the agent A tank 51 by the agent A injection pump 53 and injects it into the RO water pipe 13 little by little. The injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by the conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44 and 53. The control unit 95 adjusts based on this. The solutions of agent A and agent B injected into the RO water pipe 13 are mixed with RO water in a mixing chamber (not shown) and supplied to the dialyzer 96 as a dialysate having a predetermined concentration.

  A method for cleaning the wetted part of the dialysate supply apparatus 200 configured as described above will be described with reference to FIGS.

  The cleaning agent container 31 is attached between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30 in the same procedure as described above with reference to FIGS. Further, the flow path closing mechanism of the connectors 49a and 49b of the B agent charging mechanism 40 closes the flow paths of the connectors 49a and 49b, and the valve 48 is opened so that the cleaning / disinfecting liquid passes through the bypass pipe 47. Then, the valve 37 of the RO water pipe 13, the valve 54 of the agent A charging mechanism 50, the valve 77 of the dialysate supply pipe 73 are closed, the valve 79 of the recirculation pipe 78, and the valves 34 and 35 of the cleaning agent charging mechanism 30 are opened. And Then, RO water is introduced from the RO device 12 into the cleaning agent container 31 through the inlet pipe 32, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 33. 8, the recirculation pipe 78, the cleaning agent charging mechanism 30, the bypass pipe 47 of the B agent charging mechanism 40, the liquid feeding pump 70, and the cleaning / disinfecting liquid are circulated from the liquid feeding pump 70. First cleaning is performed.

  When the primary cleaning is completed, the cleaning / disinfecting liquid is discharged out of the system from the drain while injecting RO water into the system through the flow path R23 shown in FIG. Then, the RO water is introduced into another cleaning agent charging mechanism 130 to generate a cleaning / disinfecting solution, and the RO water pipe 13, the cleaning agent charging mechanism 30, B, and the like from the dialysate discharge pipe 80 by the flow path R24 shown in FIG. It is circulated through the agent charging mechanism 40 and the liquid feed pump 70 to perform secondary cleaning of the liquid contact portion. After the secondary cleaning, RO water is circulated through the flow path R22 shown in FIG. 8 or the flow path R24 shown in FIG. 9, and then the dialysis / cleaning solution is discharged from the drain to the outside as shown in the flow path R23 shown in FIG. The wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.

  As described above, the dialysate supply apparatus 200 of the present embodiment is similar to the dialysate supply apparatus 100 described above, and the detergent container 31 is filled and sealed by the operator with a predetermined amount of cleaning / disinfectant. Can be cleaned and disinfected by simply setting between the upper connector 36a and the lower connector 36b of the cleaning agent charging mechanism 30, so that the operator can easily touch the liquid without touching the cleaning / disinfectant. Cleaning and disinfection of the flow path can be performed. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.

  Next, a dialysate supply device 300 according to another embodiment of the present invention will be described with reference to FIGS. 10 to 17. Parts similar to those of the embodiment described above with reference to FIGS. 1 to 6 are denoted by the same reference numerals, and description thereof is omitted. As shown in FIG. 10, the dialysate supply apparatus 300 of the present embodiment generates and stores a predetermined concentration of dialysate in the tank 15, as described with reference to FIGS. 1 to 6. Is a batch-type dialysate supply device that supplies the drug to the dialyzer 96, and the drug injection mechanism 20 is capable of supplying a drug to the tank 15 by attaching a drug container (A agent container 21A, B agent container 21B), The cleaning agent containers 21 </ b> C and 21 </ b> D may be attached to supply the cleaning / disinfecting liquid to the tank 15. Further, in the dialysate supply device 300 of the present embodiment, as in the dialysate supply devices 100 and 200 described above, another wash is provided in the dialysate discharge pipe 80 as an option, as indicated by a broken line in FIG. An agent charging mechanism 130 is arranged, the dialysate discharge pipe 80 and the RO water pipe 13 are connected by another recirculation pipe 178, and a valve 179 is arranged in the recirculation pipe 178.

  As shown in FIG. 11, the medicine injection mechanism 20 includes a storage unit 720 that holds the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D, a motor 708 that rotates the storage unit 720, and an upper side. The first connector 26a, the lower second connector 26b, and a connector moving mechanism 560 for moving the connectors 26a and 26b in the vertical direction.

  The storage unit 720 is obtained by integrally fixing an upper disc 700 having a plurality of holes 701 to 704 and a lower disc 710 as shown in FIGS. 12A and 12B with a connection shaft 707. As shown in FIG. 12A, the upper disc 700 has a plurality of large round holes 701 for receiving the main body 21Ae of the agent A container 21A shown in FIG. 11 and a plurality of small holes for receiving the main bodies 21Be of the agent B container 21B shown in FIG. A round hole 702, a large square hole 703 for receiving the main body 21Ce of the cleaning agent container 21C shown in FIG. 11, and a small square hole 704 for receiving the main body 21De of the cleaning agent container 21D shown in FIG. The internal dimensions of the holes 701 to 704 are substantially the same as the external dimensions of the main bodies 21Ae to 21De of the containers 21A to 21D. Further, the lower disc 710 has lower neck portions 21Ab to 21Db of the containers 21A to 21D shown in FIG. 11 at positions corresponding to the round holes 701 and 702 and the square holes 703 and 704 of the upper disc 700, respectively. A plurality of round holes 711 into which are inserted. The diameter of the round hole 711 should just be larger than the outer diameter of each lower neck part 21Ab-21Db, and smaller than the external dimension of each main body 21Ae-21De. The center of the upper disc 700 and the lower disc 710 is connected by a boss 706, and a shaft 705 is attached to the center of the boss 706. As shown in FIG. 11, the shaft 705 is connected to the shaft 705 of the motor 708, and the storage unit 720 is configured to rotate by the motor 708. As shown in FIG. 11, the first connector 26a and the second connector 26b are connected to the connector moving mechanism 560 by arms 506 and 606, respectively. As shown in FIGS. 14 and 15, the first connector 26a and the second connector 26b are arranged so that their centers are on the same center line 580, and are opened in the upper disk 700 of the storage unit 720. The holes 701 to 704 and the plurality of round holes 711 formed in the lower disk 710 are arranged so that their centers are on the circumference intersecting the center line 580 of the first connector 26a and the second connector 26b. Has been. Therefore, by rotating the storage unit 720, the center axes of the predetermined containers 21A to 21D can be aligned with the center lines 580 of the first connector 26a and the second connector 26b. The storage unit 720 is connected to the control unit 95 and rotates according to a command from the control unit 95.

  The bases 500 and 600 of the first connector 26a and the second connector 26b have the same configuration as the bases 500 and 600 of the upper connector 36a and the lower connector 36b described above with reference to FIG. The first fitting block 510 and the lower second fitting block 610 are different from the upper fitting block 550 and the lower fitting block 650 described with reference to FIG. 3 in the first main body 510a and the second main body 610a. An annular three-stage hole is provided.

  As shown in FIG. 13, the first main body 510a has an annular shape and is provided with a circular three-stage hole in the center. A nozzle mounting hole 513 is provided on the upper base 500 side of the first main body 510a, and a second fitting hole in which the annular upper neck portion 21Ca of the cleaning agent container 21C is fitted, as shown in FIG. As shown in FIG. 14, a first fitting hole 515 into which the upper neck portion 21Ba of the B agent container 21B is fitted is provided between the nozzle mounting hole 513 and the second fitting hole 517. Is provided. The inner diameter of the second fitting hole 517 is larger than the inner diameter of the first fitting hole 515. The inner diameter of the first fitting hole 515 and the inner diameter of the second fitting hole 517 are substantially the same as the outer diameter of the upper neck portion 21Ba of the B agent container 21B and the upper neck portion 21Ca of the cleaning agent container 21C, respectively. A packing 514 for watertightly sealing the outer surface of the upper nozzle 503 is attached to the inner surface of the nozzle mounting hole 513, and the upper neck portion 21Ba of the B agent container 21B is attached to the inner surface of the first fitting hole 515. A packing 516 for watertight sealing between the outer surface and the outer surface is attached, and a packing 518 for watertight sealing between the outer surface of the upper neck portion 21Ca of the cleaning agent container 21C is attached to the inner surface of the second fitting hole 517. Is attached. The first fitting hole 515 and the packing 516 constitute a first fitting portion, and the second fitting hole 517 and the packing 518 constitute a second fitting portion.

  As shown in FIG. 13, the second main body 610a is also annular and has a circular three-stage hole in the center, like the first main body 510a. A nozzle mounting hole 613 is provided on the lower base 600 side of the second main body 610a, and a fourth fitting hole in which the annular lower neck portion 21Cb of the cleaning agent container 21C is fitted, as shown in FIG. As shown in FIG. 14, a third fitting hole 615 into which the lower neck portion 21Bb of the B agent container 21B is fitted is provided between the nozzle mounting hole 613 and the fourth fitting hole 617. Is provided. The inner diameter of the fourth fitting hole 617 is larger than the inner diameter of the third fitting hole 615. The inner diameter of the third fitting hole 615 and the inner diameter of the fourth fitting hole 617 are approximately the same diameter as the outer diameter of the lower neck portion 21Bb of the B agent container 21B and the lower neck portion 21Cb of the cleaning agent container 21C, respectively. A packing 614 for watertightly sealing the outer surface of the lower nozzle 603 is attached to the inner surface of the nozzle mounting hole 613, and the inner surface of the third fitting hole 615 is attached to the lower neck portion 21Bb of the B agent container 21B. A packing 616 is provided for watertight sealing between the outer surface and a packing 618 for watertight sealing between the outer surface of the lower neck portion 21Cb of the cleaning agent container 21C and the inner surface of the fourth fitting hole 617. Is attached. The third fitting hole 615 and the packing 616 constitute a third fitting portion, and the fourth fitting hole 617 and the packing 618 constitute a fourth fitting portion.

  In the above description, the B agent container 21B and the cleaning agent container 21C have been described as examples. However, the outer diameters of the upper neck portion 21Aa, the lower neck portion 21Ab, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are as follows. The upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B are the same as the outer diameters of the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C. The upper neck portion 21Aa and the lower neck portion 21Ab of the A agent container 21A are respectively the same. The first and third fitting holes 515 and 615 are fitted, and the upper neck portion 21Da and the lower neck portion 21Db of the cleaning agent container 21D are fitted into the second and fourth fitting holes 517 and 617, respectively. The agent A container 21A, the agent B container 21B, and the cleaning agent containers 21C and 21D are containers 21 that can be held in the storage unit 720.

  As shown in FIG. 14, in order to attach the B agent container 21 </ b> B between the first connector 26 a and the second connector 26 b of the medicine injection mechanism 20, first, the A agent containers 21 </ b> A, B are inserted into the holes 701 to 704 of the storage unit 720. The agent container 21B, the detergent container 21C, and the detergent container 21D are set in advance. Then, after closing the valves 24 and 25 shown in FIG. 10, the first connector 26 a is moved upward and the second connector 26 b is moved downward by the connector moving mechanism 560, and the tip of the upper nozzle 503 and the lower nozzle 603 are moved. Is made longer than the overall length of the B agent container 21B in the vertical direction. Thereafter, the storage unit 720 is rotated by the motor 708 shown in FIG. 11, and the center of the B agent container 21B is set at the same position as the center line 580 of the first and second connectors 26a and 26b as shown in FIG. The moving mechanism 560 moves the second connector 26b upward and the first connector 26a downward. Then, the second connector 26b breaks the sealing material 21Bd at the sharp tip of the lower nozzle 603 and enters the B agent container 21B, and the third fitting hole 615 fits into the outer periphery of the lower neck portion 21Bb. And the packing 616 of the 3rd fitting hole 615 closely_contact | adheres to the outer periphery of lower neck part 21Bb. Similarly, the first connector 26a breaks the sealing material 21Bc at the sharp tip of the upper nozzle 503 and enters the B agent container 21B, and the first fitting hole 515 fits into the outer periphery of the upper neck portion 21Ba. And the packing 516 of the 1st fitting hole 515 closely_contact | adheres to the outer periphery of upper neck part 21Ba. As a result, as shown in FIG. 14, the B agent container 21B is sandwiched between the first connector 26a and the second connector 26b, and the B agent container 21B, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.

  In this state, the valves 24 and 25 are opened, and RO water is introduced into the B agent container 21 </ b> B to dissolve the B agent into a high-concentration solution and flow into the tank 15 from the drug introduction pipe 14. When the charging is completed, the first connector 26a and the second connector 26b are moved so as to open in the vertical direction, and the distance between the tip of the upper nozzle 503 and the tip of the lower nozzle 603 is larger than the total length in the vertical direction of the B agent container 21B. After that, the storage unit 720 is rotated so that the center of the agent A container 21A is located at the same position as the center line 580 of the first and second connectors 26a and 26b, and the connector moving mechanism 560 is operated to operate the agent A. The container 21A is attached between the first and second connectors 26a and 26b. And RO water is introduce | transduced into the A agent container 21A, A agent is melt | dissolved to make a high concentration solution, and it flows in into the tank 15 from the chemical | medical agent injection pipe 14. FIG. Then, RO water is allowed to flow into the tank 15 until a predetermined concentration is reached to generate a dialysate having a predetermined concentration, and the dialysate in the tank 15 is supplied to the dialyzer 96 by the liquid feed pump 70.

  Next, a method for cleaning and disinfecting the liquid contact portion of the dialysate supply apparatus 200 by attaching the cleaning agent container 21C to the medicine charging mechanism 20 will be described with reference to FIGS. First, the valves 24 and 25 shown in FIG. 10 are closed, and the cleaning agent container 21 </ b> C is attached to the medicine charging mechanism 20. Further, the couplers 81 and 82 are removed from the dialysate inlet 91 and the dialysate outlet 92 of the dialyzer 90 and connected by a connection coupler 98. The coupler 81 and the coupler 82 may be directly connected without using the connection coupler 98.

  The process of attaching the cleaning agent container 21C to the medicine injection mechanism 20 is the same as the process of attaching the B agent container 21B described above to the medicine injection mechanism 20, but as shown in FIG. 15, the fourth of the second connector 26b. The fitting hole 617 is fitted into the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C, and the packing 618 of the fourth fitting hole 617 is in close contact with the outer periphery of the lower neck portion 21Cb. Similarly, the second fitting hole 517 of the first connector 26a is fitted into the outer periphery of the upper neck portion 21Ca. And the packing 518 of the 2nd fitting hole 517 closely_contact | adheres to the outer periphery of upper neck part 21Ca. As a result, as shown in FIG. 15, the cleaning agent container 21C is sandwiched between the first connector 26a and the second connector 26b, and the cleaning agent container 21C, the inlet pipe 22 and the outlet pipe 23 communicate with each other. To form one liquid flow path.

  As shown in FIG. 15, when the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C are fitted in the second and fourth fitting holes 517 and 617 of the first and second connectors 26a and 26b, respectively, 14 with reference to FIG. 14, the inner surfaces of the first and third fitting holes 515 and 615 in which the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B are fitted, and the upper nozzle 503 and the lower nozzle 603 There is a space between each outer surface. For this reason, the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 where the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb are in contact with each other when the B agent container 21B is attached to the medicine charging mechanism 20. The B agent or the A agent remaining on the contact surfaces inside the fitting holes 515 and 615 can be washed.

  As shown in FIG. 15, when the cleaning agent container 21C is attached between the first connector 26a and the second connector 26b, as shown in FIG. 16, the valve 24 disposed in the inlet pipe 22 and the outlet pipe 23 When the valve 25 arranged at is opened, RO water flows from the inlet pipe 22 into the flow hole 502 of the flat plate 501 of the first connector 26a, as shown in FIG. As shown in FIG. 15, the RO water that has flowed into the flow hole 502 flows into the cleaning agent container 21 </ b> C from the flow hole 505 on the tip side of the upper nozzle 503 through the flow hole 504 of the upper nozzle 503. When the cleaning / disinfecting agent filled in the cleaning agent container 21C is in a powder state, the cleaning / disinfecting agent dissolves in the RO water in the cleaning agent container 21C to become a high concentration cleaning / disinfecting solution, It flows out from the outlet pipe 23 through the flow holes 605 and 604 of the lower nozzle 603, through the flow holes 602 of the flat plate 601. Then, as shown in a flow path R31 of FIG. The water supply pump 11 supplies RO water from the RO device 12 to the tank 15 until the concentration of the cleaning / disinfecting liquid in the tank 15 reaches a predetermined concentration. When the concentration of the cleaning / disinfectant in the tank 15 reaches a predetermined concentration, or when a predetermined amount of RO water is supplied to the tank 15, the water supply pump 11 is stopped.

  Next, when the valves 77 and 179 are closed and the valve 79 is opened and the liquid feed pump 70 is started, the cleaning / disinfecting liquid stored in the tank 15 is as shown by a flow path R32 indicated by a one-dot chain line in FIG. [Tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → recirculation pipe 78 (valve 79) → RO water pipe 13 → drug injection mechanism 20 → drug injection pipe 14 → Tank 15] to circulate and clean and disinfect the wetted parts of each device and piping. When the cleaning / disinfection of the flow path R32 shown in FIG.

  When the cleaning / disinfection of the flow path R32 is completed, the valve 79 is closed and the valve 77 is opened as shown in FIG. Then, as shown in the flow path R33 in FIG. 17, the cleaning / disinfecting liquid stored in the tank 15 is [tank 15 → pump suction pipe 16 → liquid feed pump 70 → heater inlet pipe 71 → heater 72 → dialysate. Supply pipe 73 → valve 77 → connection pipe 76 → coupler 81 → connection coupler 98 → coupler 82 → dialysate discharge pipe 80], and is discharged from the drain to the outside of the system. When all of the cleaning / disinfecting solution stored in the tank 15 is discharged from the drain through the flow path R33, the primary cleaning of the liquid contact portion of the dialysate supply device 300 is finished.

  Next, in the same procedure as described above with reference to FIGS. 1 to 6, the cleaning agent container 131 is attached to another cleaning agent charging mechanism 130, and the RO device 12 is transferred from the RO device 12 to the tank 15 by the water supply pump 11. A predetermined amount of RO water is stored, the valves 134 and 135 of the cleaning agent charging mechanism 130 are opened, and the RO water is introduced from the tank 15 into the cleaning agent container 131 by the liquid feed pump 70, and the cleaning / disinfecting solution is supplied to the flow path R34. As shown, [detergent input mechanism 130 → dialysate discharge pipe 80 → recirculation pipe 178 (valve 179) → RO water pipe 13 → cleaner input mechanism 30 → drug input pipe 14 → tank 15 → pump suction pipe 16 → feed Secondary cleaning is performed by circulating fluid pump 70 → heater inlet pipe 71 → heater 72 → dialysate supply pipe 73 → valve 77 → connecting pipe 76 → coupler 81 → connecting coupler 98 → coupler 82 → cleaning agent charging mechanism 130]. Do. When the channel R34 shown in FIG. 17 is cleaned and disinfected for a predetermined time, the secondary cleaning is finished. When the secondary cleaning is completed, the valve 179 is closed and the cleaning / disinfecting liquid remaining in the tank 15 is discharged from the drain to the outside through the flow path R33.

  Thereafter, the RO water is caused to flow into the system by the water supply pump 11 while circulating the flow path R32 shown in FIG. 16 or the flow path R34 shown in FIG. Flushing is performed to discharge the RO water accumulated in the tank 15 from the drain to the outside of the system by the flow path R33 shown in FIG. 17, and the cleaning / disinfection of the liquid contact portion of the dialysate supply device 300 is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.

  As described above, in the dialysate supply device 300 according to the present embodiment, the operator puts the cleaning agent container 21C or 21D filled and sealed with a predetermined amount of the cleaning / disinfecting agent into the hole 703 of the storage unit 720 of the medicine charging mechanism 20. 704, the fluid contact part of the dialysate supply device 300 can be cleaned and disinfected, so that the operator can easily clean and disinfect the liquid flow path without touching the cleaning / disinfectant. It can be carried out. Further, the dialysate supply device 300 of the present embodiment can supply the A agent, the B agent, and two types of cleaning / disinfecting agents to the pipe or the tank 15 by the single medicine input mechanism 20, and thus has a simple configuration. It can be. In addition, when the medicine or the cleaning agent is added, a series of processes such as rotation and positioning of the storage unit 720, sandwiching and removing of the container 21 by the first and second connectors 26 a and 26 b are collectively controlled by commands of the control unit 95. As a result, automation can be achieved, and the liquid channel can be easily cleaned and disinfected without the operator touching the cleaning / disinfectant. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.

  Furthermore, the dialysate supply apparatus 300 of the present embodiment includes the main bodies 21Ae, 21Be, 21Ce, and 21De of the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D that are held in the storage unit 720 by the control unit 95. Since the shape is different and the holes 701 to 704 are provided in the upper disk 700 of the storage unit 720 according to the shape of each main body, the A agent container 21A, the B agent container 21B, and the cleaning agent containers 21C and 21D are provided. You can avoid mistakes. In addition, an IC chip or the like is attached to each of the containers 21A to 21D, and the control unit 95 rotates the storage unit 720 to select the A agent container 21A, the B agent container 21B, or the cleaning agent containers 21C and 21D. The center line 580 between the first connector 26a and the second connector 26b is such that the container 21 filled with the correct medicine or cleaning agent is determined by determining whether the container 21 is filled with the medicine from the information on the IC chip. It is possible to prevent an erroneous injection of the medicine by controlling it so as to be positioned above.

  Furthermore, as shown in FIG. 15, the dialysate supply apparatus 300 of the present embodiment connects the upper neck portion 21Ca and the lower neck portion 21Cb of the cleaning agent container 21C with the first and second connectors 26a and 26b, respectively. When fitted into the fitting holes 517 and 617, the first and third fitting holes 515 and 615 in which the upper neck portion 21Ba and the lower neck portion 21Bb of the B agent container 21B described above with reference to FIG. There is a space between the inner surface and the outer surfaces of the upper nozzle 503 and the lower nozzle 603. For this reason, the cleaning liquid also passes through the inner surfaces of the first and third fitting holes 515 and 615 where the outer surfaces of the upper neck portion 21Ba and the lower neck portion 21Bb are in contact with each other when the B agent container 21B is attached to the medicine charging mechanism 20. The B agent or the A agent remaining on the contact surfaces inside the fitting holes 515 and 615 can be washed.

  Next, a dialysate supply apparatus 400 according to another embodiment of the present invention will be described with reference to FIGS. Parts similar to those of the embodiment described with reference to FIGS. 1 to 17 are denoted by the same reference numerals and description thereof is omitted.

  The dialysate supply device 400 shown in FIG. 18 is continuously charged with a high concentration of agent A and agent B into the RO water pipe 13 little by little, like the dialysate supply device 200 described above with reference to FIG. Thus, a dialysate having a predetermined concentration is generated and supplied to the dialyzer 96. The configuration of the medicine injection mechanism 60 of the present embodiment is the same as the first and second connectors 26a and 26b and the connector moving mechanism 560 described above with reference to FIGS. 126a, 126b, and a connector moving mechanism 560, which are configured so that the B agent container 21B and the cleaning agent containers 21C, 21D can be attached. Note that the storage unit 720 described with reference to FIGS. 11, 12A, and 12B is not provided. Similarly to the embodiment described above, the dialysate supply device 400 of this embodiment includes another cleaning agent charging mechanism 130 in the dialysate discharge pipe 80, and connects the dialysate discharge pipe 80 and the RO water pipe 13. Another recirculation pipe 178 and a valve 179 are provided.

  When the dialysate is supplied to the dialyzer 96 by the dialysate supply device 400 shown in FIG. 18, as shown in FIG. 14, the first fitting of the first connector 126a is performed on the outer periphery of the upper neck portion 21Ba of the B agent container 21B. The B agent container 21B is fitted into the first and second connectors so that the hole 515 and the packing 516 are fitted, and the third fitting hole 615 and the packing 616 of the second connector 126b are fitted into the outer periphery of the lower neck portion 21Bb of the B agent container 21B. The B agent container 21B, the inlet pipe 122, and the outlet pipe 123 communicate with each other so as to form one liquid flow path.

  In this state, the valves 124 and 125 are opened, the RO water is introduced into the B agent container 21B, the B agent is dissolved to produce a high concentration solution, and the B agent injection pump 44 has a concentration in the RO water pipe 13. B solution of B is injected little by little. In addition, the A agent is sucked up from the A agent tank 51 by the A agent injection pump 53 and injected into the RO water pipe 13 little by little. The injection amount of the B agent injection pump 44 and the injection amount of the A agent injection pump 53 are the conductivity detected by the conductivity sensor (not shown) attached to the RO water pipe 13 on the downstream side of each of the injection pumps 44 and 53. The control unit 95 adjusts based on this. The solutions of the B agent and the A agent injected into the RO water pipe 13 are mixed in a mixing chamber (not shown) to become a predetermined concentration dialysate and supplied to the dialyzer 96.

  A method for cleaning the wetted part of the dialysate supply apparatus 400 configured as described above will be described with reference to FIGS. 19 and 20.

  First, the valves 124 and 125 are closed, the B agent container 21B attached between the first and second connectors 126a and 126b of the medicine injection mechanism 120 is removed, and the cleaning agent container 21C is the same as described above. It attaches between the 1st, 2nd connectors 126a and 126b by a method. In this case, as shown in FIG. 15, the second fitting hole 517 and the packing 518 of the first connector 126a are fitted into the outer periphery of the upper neck portion 21Ca of the cleaning agent container 21C, and the outer periphery of the lower neck portion 21Cb of the cleaning agent container 21C. The cleaning agent container 21C is sandwiched between the first and second connectors 126a and 126b so that the fourth fitting hole 617 and the packing 618 of the second connector 126b are fitted into the first connector 126b, the cleaning agent container 21C, the inlet pipe 122, and the outlet pipe. 123 communicates with each other to form one liquid flow path.

  Next, the valve 54 of the agent A charging mechanism 50 and the valve 77 of the dialysate supply pipe 73 are closed, and the valves 124 and 125 and the valve 79 of the recirculation pipe 78 are opened. Then, RO water is introduced from the RO device 12 into the cleaning agent container 21 </ b> C through the inlet pipe 122, and the cleaning / disinfecting liquid is caused to flow into the RO water pipe 13 from the outlet pipe 123. Then, the primary cleaning is performed by circulating the cleaning / disinfecting liquid through the recirculation pipe 78, the medicine feeding mechanism 120, the liquid feeding pump 70 and the cleaning / disinfecting liquid as shown in the flow path R42 shown in FIG.

  When the primary cleaning is completed, the cleaning / disinfecting liquid is discharged out of the system from the drain while injecting RO water into the system through the flow path R43 shown in FIG. Further, the RO water is introduced into another cleaning agent charging mechanism 130 to generate cleaning / disinfecting liquid, and the recirculation pipe 178, the RO water pipe 13, and the chemicals are input from the dialysate discharge pipe 80 through the flow path R44 shown in FIG. By circulating through the mechanism 60 and the liquid feed pump 70, the wetted part is subjected to secondary cleaning. After the secondary cleaning, RO water is circulated through the flow path R42 shown in FIG. 19 or the flow path R44 shown in FIG. 20, and then the dialysis / cleaning liquid is discharged from the drain to the outside as shown in the flow path R43 shown in FIG. The wetted part is flushed and the cleaning / disinfection work is completed. If the cleaning agent charging mechanism 130, the recirculation pipe 178, and the valve 179 are not provided, only the primary cleaning may be performed.

  As described above, as in each of the embodiments described in the dialysate supply apparatus 400 of this embodiment, the operator puts the cleaning agent container 21C filled and sealed with a predetermined amount of the cleaning / disinfectant into the medicine charging mechanism 120. Since the liquid contact part can be cleaned and disinfected by simply setting it between the first connector 126a and the second connector 126b, the operator can easily clean the liquid flow path without touching the cleaning / disinfectant.・ Can disinfect. In addition, the first and second connectors 126a and 126b of the drug injection mechanism 120 of the dialysate supply apparatus 400 of the present embodiment can be attached with either a drug container or a detergent container, and supply dialysate with a simple configuration. The apparatus 400 can be cleaned and disinfected. In addition, since the cleaning / disinfecting agent does not come into contact with the atmosphere, the odor diffusion of the cleaning / disinfecting agent can be suppressed.

DESCRIPTION OF SYMBOLS 10 Water supply pipe, 11 Water supply pump, 12 RO apparatus, 13 RO water pipe, 14 Drug injection pipe, 15 Tank, 16 Pump suction pipe, 20, 55, 60, 120 Drug injection mechanism, 21 container, 21A A agent container, 21B, 41B agent container, 21C, 21D, 61 Drug container, 21Aa, 21Ba, 21Ca, 21Da, 31a, 61a Upper neck, 21Ab, 21Bb, 21Cb, 21Db, 31b, 61b Lower neck, 21Bc, 21Bd, 21Cc, 21Cd , 31c, 31d, 61c, 61d Sealing material, 21Ae, 21Be, 21Ce, 21De, 31e, 61e Main body, 22, 32, 42, 62, 122, 132 Inlet pipe, 23, 33, 43, 63, 123, 133 Outlet Tube, 24, 25, 34, 35, 45, 46, 48, 64, 65, 77, 79, 124, 25, 134, 135, 179 Valve, 26a, 126a First connector, 26b, 126b Second connector, 30, 130 Cleaning agent charging mechanism, 31 Cleaning agent container, 36a, 66a, 136a Upper connector, 36b, 66b, 136b Lower Connector, 40 B agent injection mechanism, 44 B agent injection pump, 47 Bypass pipe, 49a, 49b Connector, 50 A agent injection mechanism, 51 A agent tank, 52 injection tube, 53 A agent injection pump, 70 Liquid feed pump, 71 Heater inlet pipe, 72 heater, 73 dialysate supply pipe, 74 temperature sensor, 75, 83 flow sensor, 76 connecting pipe, 78,178 recirculation pipe, 80 dialysate discharge pipe, 81,82 coupler, 90 dialyzer, 91 dialysis Fluid inlet, 92 dialysate outlet, 93 blood inlet tube, 94 blood outlet tube, 95 control unit, 96 dialyzer, 97a dialysate Infusion pump (dialysate IN pump), 97b dialysate discharge pump (dialysate OUT pump), 97c blood pump, 98 connection coupler, 100,200,300,400 dialysate supply device, 500 upper base, 501,601 flat plate, 502, 504, 505, 602, 604, 605 Flow hole, 513, 553, 613, 653 Nozzle mounting hole, 503 Upper nozzle, 506, 606 Arm, 510 First fitting block, 510a First body, 514, 516 518,552,554,556,614,616,618,652,645,656 packing, 515 first fitting hole, 517 second fitting hole, 550 upper fitting block, 550a upper body, 551, 651 flange, 555 Upper fitting hole, 558, 658 bolt, 560 connector moving mechanism, 580 center line, 600 Lower base, 603 Lower nozzle, 610 Second fitting block, 610a Second body, 615 Third fitting hole, 617 Fourth fitting hole, 650 Lower fitting block, 650a Lower body, 652 Packing, 655 Bottom fitting Joint hole, 700 Upper disk, 701, 702, 711 Round hole, 703, 704 Square hole, 705 Shaft, 706 Boss, 707 Connection shaft, 708 Motor, 710 Lower disk, 720 Storage part.

Claims (7)

A dialysis fluid supply device that mixes a drug and a diluent to produce a dialysis fluid, and supplies the dialysis fluid to a dialysis device,
A cleaning / disinfecting agent for cleaning and disinfecting the wetted part in contact with the dialysate of the dialysate supply device is provided with a cleaning agent charging mechanism for charging the pipe through which the diluent flows.
The cleaning agent charging mechanism is configured such that a cleaning agent container containing the cleaning / disinfecting agent, a pipe on one end side of the cleaning agent container, and a pipe on the other end side of the cleaning agent container communicate with each other. A dialysate supply apparatus that sandwiches the detergent container between the one end side pipe and the other end side pipe so as to form a path. The dialysate supply device according to claim 1,
An annular upper connector in which the root side is connected to the pipe on the one end side, and the tip end side is fitted in a watertight manner on the outer periphery of the upper neck portion protruding to the one end side of the cleaning agent container;
An annular lower connector that is disposed coaxially with the upper connector, has a root side connected to the pipe on the other end side, and has a tip end side that is watertightly fitted to the outer periphery of the lower neck portion protruding to the other end side of the cleaning agent container;
A connector moving mechanism for moving one or both of the upper and lower connectors along the longitudinal direction of the cleaning agent container,
Each said connector is a dialysate supply apparatus provided with the nozzle which penetrates the sealing member which each seals each end surface of each said neck part in the cyclic | annular center vicinity. A dialysis fluid supply device that mixes a drug and a diluent to produce a dialysis fluid, and supplies the dialysis fluid to a dialysis device,
A drug charging mechanism for charging the drug into a pipe through which the diluent flows,
The drug injection mechanism is
The one end side pipe so that the medicine container containing the medicine, the one end side pipe of the medicine container, and the other end side pipe of the medicine container communicate with each other to form one liquid channel; A cleaning / disinfectant capable of sandwiching the drug container between the pipe on the other end side and cleaning / disinfecting the liquid contact part of the dialysate supply device in contact with the dialysate instead of the drug container The dialysis fluid supply apparatus is capable of sandwiching the detergent container containing the gas between the one end side pipe and the other end side pipe. The dialysate supply device according to claim 3,
The drug injection mechanism is
A first fitting portion that is connected to the pipe on the one end side and has a distal end side that is watertightly fitted to the first outer periphery of the first neck portion that projects to one end side of the drug container, and projects to one end side of the cleaning agent container. An annular first connector including a first fitting portion that fits in a watertight manner on a second outer periphery of the second neck portion and a second fitting portion having a different shape;
A third fitting that is arranged coaxially with the first connector, has a root side connected to the pipe on the other end side, and a tip end side that is watertightly fitted to the third outer periphery of the third neck portion protruding to the other end side of the drug container. An annular second connector including a first fitting portion and a fourth fitting portion having a different shape from a third fitting portion fitted in a watertight manner on the fourth outer periphery of the fourth neck portion protruding to the other end side of the cleaning agent container ,
A connector moving mechanism for moving either one or both of the first or second connectors along the longitudinal direction of the drug container or the cleaning agent container,
Said 1st, 2nd connector is a dialysate supply apparatus provided with the nozzle which penetrates the sealing member which each seals each end surface of each said neck part in the cyclic | annular center vicinity. The dialysate supply device according to claim 4,
The second fitting portion of the first connector has an inner diameter larger than that of the first fitting portion, and is disposed closer to the distal end side of the first connector than the first fitting portion.
The fourth fitting portion of the second connector has an inner diameter larger than that of the third fitting portion, and is provided on the distal end side of the second connector with respect to the third fitting portion. apparatus. The dialysate supply device according to any one of claims 3 to 5,
A storage unit for holding at least one drug container and at least one cleaning agent container;
A dialysis fluid supply apparatus comprising: a feed mechanism that transfers any one container from the storage unit between the first connector and the second connector. The dialysate supply device according to claim 6,
The said storage part is a dialysate supply apparatus provided with the 1st hole which hold | maintains the said chemical | medical agent container, and the 1st hole which hold | maintains the said washing | cleaning agent container, and a 2nd hole from which a shape differs.

Images