WO2017051762A1 - Diagnosis assisting system, and diagnosis assisting information display method - Google Patents

Abstract

Provided is a technique for effectively outputting information in such a way that a diagnosis relating to a medical condition of an examinee (patient), or a diagnosis relating to the effect of treatment on the medical condition, can be made objectively. According to this technique, information relating to a subject, and treatment information with respect to the subject, are acquired from a database, and a biological signal is acquired from a measuring unit which measures the biological signal at a prescribed site in the subject. The information relating to the subject, the treatment information and the biological signal are then integrated to generate integrated information. Furthermore, a display process is executed to display simultaneously on a screen of a display device a plurality of types of information contained in the integrated information, as an inspection result display (see figure 13).

Description

Diagnostic assistance system and diagnostic assistance information display method

The present disclosure relates to a diagnostic assistance system and a diagnostic assistance information display method, for example, a technique for assisting diagnosis related to a function of an organ of a subject.

● Attention 注意 Deficit and Hyperactivity Disorders: ADHD is one of the typical brain dysfunctions, with inattention, hyperactivity and impulsivity as core symptoms. Conventional methods for diagnosing ADHD focus on behavioral observation, and are often subjectively determined by a doctor. In addition, methylphenidate hydrochloride (MPH), a therapeutic agent for ADHD, and how Atomoxetine (ATX) works in the brain. In many cases, the internal dose was determined based on behavioral observation.

However, behavior observation is an evaluation method that relies on the subjectivity of the observer. Therefore, it has been necessary to develop an objective evaluation method for diagnosis and treatment effect by visualizing changes in brain function characteristic of ADHD. For example, Non-Patent Document 1 shows that, as a material for objective evaluation, visualizing a drug treatment effect on an ADHD child by optical brain function measurement. In addition, Non-Patent Document 1 and Non-Patent Document 2 clarify that there is a recovery effect of the brain function unique to each drug depending on the type of drug and the activity content of the brain. At present, when visualizing the drug treatment effect, as shown in Patent Document 1, for example, as shown in Patent Document 1, a map of a signal waveform and a statistical value of a measurement data and a map showing an active area are displayed, as shown in Patent Document 1. Often displayed.

Japanese Patent No. 4559417

However, the conventional measurement result display methods and combinations thereof are not sufficiently effective display methods from the viewpoint of treatment judgment and efficacy evaluation. Further, in Patent Document 1, since measurement data is displayed as a map regardless of the treatment information of the subject (patient), it is not sufficient as an aid for evaluating the effect of treatment on the subject. For this reason, there is a need for an effective result display method for prompting doctors to make treatment decisions and help patients understand their medical condition.

The present disclosure has been made in view of such a situation, and a technique for effectively outputting information so as to be able to objectively diagnose a medical condition determination of a subject (patient) and a treatment effect on symptoms. provide.

In order to solve the above problems, a diagnostic assistance system according to the present disclosure acquires information on a subject and treatment information on the subject from a database, and also from a measurement unit that measures a biological signal at a predetermined part of the subject. Obtain a biological signal. Then, the system integrates information about the subject, treatment information, and biological signals to generate integrated information, and displays a plurality of types of information included in the integrated information on the screen of the display device as a test result display. At the same time, display processing for parallel display is executed.

Further features related to the present disclosure will become apparent from the description of the present specification and the accompanying drawings. The aspects of the present disclosure are achieved and realized by elements and combinations of various elements and the following detailed description and appended claims.
It should be understood that the description herein is exemplary only, and is not intended to limit the scope of the claims or the application in any way whatsoever.

According to the present disclosure, it is possible to more effectively and quantitatively evaluate the symptom improvement effect by treatment such as medication. Assists doctors in determining drug efficacy through simultaneous display of time-series information. Comprehensive judgment can be assisted for doctors and operators. Data on therapeutic effects can be provided to patients and their families to help determine drug selection.

It is a figure which shows schematic structure of the brain function parameter | index output apparatus (it is also called a diagnostic assistance apparatus or a diagnostic assistance system) 100 and peripheral devices by embodiment of this indication. It is a figure which shows schematic structure of the brain function parameter | index output apparatus 100 and peripheral device by the modification of embodiment of this indication. It is a figure which shows the sequence of the process performed in each structure part and each peripheral device of the brain function parameter | index output apparatus 100 by embodiment of this indication. It is a figure showing an example of composition of diagnostic auxiliary information 400 by an embodiment of this indication. 5 is a flowchart for describing processing until a test result report is displayed, which is executed by the brain function index output device 100 according to the embodiment of the present disclosure. It is a figure which shows the initial setting (default) structure (example) 600 of the test result display (optical topography test report) by this embodiment. It is a figure which shows the structural example of the display item selection screen 700 for selecting the item of the subject displayed on a subject display area by this embodiment. It is a figure which shows the structural example of the layout setting screen 800 of a test result display by this embodiment. It is a figure which shows the structural example of the file selection screen 900 by this embodiment. It is an example of the flowchart for demonstrating the setting process of the region of interest (Region | of_interest: ROI) by this embodiment. It is a figure which shows the structural example of the parameter setting screen 1100 by this embodiment. It is a figure which shows the structural example of the region-of-interest setting screen 1200 by this embodiment. It is a figure which shows the structural example of the customized test result display 1300 by this embodiment. It is a figure which shows the structural example of the layout setting screen 1400 of a test result display by the modification of this embodiment. It is a figure which shows the example of a display of ADHD evaluation scale graph 1501 and ADHD evaluation scale table 1502 which can be displayed on the screen of the test result display by this embodiment. It is a figure which shows the example of a display of the feature-value map 1600 which can be displayed on the screen of the test result display by this embodiment. It is a figure which shows the example of a display of the radar chart 1700 which can be displayed on the screen of a test result display by this embodiment. In the figure (graph) which shows the relationship (example) of the change (increase) of the problem correct answer rate obtained when the subject performed the task and the reaction time spent when answering the task according to the present embodiment is there.

In the embodiment of the present disclosure, when outputting and displaying as an index indicating the effect of a specific medicine, treatment information necessary for a judgment by a doctor, past measurement information, a subject attribute, and the like are given simultaneously. To. Measurement data of optical brain function measurement (for example, optical topography method), indices related to drug effects, treatment information, and the like are output or displayed in time series and effectively for doctors, operators, patients, and patient families. Furthermore, time-series information useful for diagnosis by a doctor is output and displayed with high reproducibility to a doctor, an operator, or a subject in an integrated and effective manner depending on treatment information. The treatment information and the brain activity information are displayed simultaneously, and the display ROI corresponding to the presence / absence of the treatment information and past information is optimized. In addition, a display method in which the brain function index and the treatment information of the past multiple times are associated is realized. In the inspection result display according to the implementation system of the present disclosure, the difference value display method is determined by determining whether or not the difference value of the amplitude amount is equal to or greater than a predetermined threshold (a magnitude relationship between the amplitude value and the predetermined threshold) change. The display method includes a background color of the difference value, a font for displaying the numerical value of the difference value, and a character color. Further, the measurement position to be displayed is selected according to the treatment information and the task to be used. Here, the treatment information is medication information including type, amount, and frequency of medicine, treatment history, and examination history including brain activity measurement. In particular, the measurement position to be displayed is changed by selecting a medicine or a task. For example, the prefrontal cortex (frontal part) is displayed during the suppression task (eg, Go / No-Go task), and the prefrontal cortex and parietal lobe are displayed during the attention task (eg, Oddball task). Alternatively, the prefrontal cortex may be displayed when MPH (methylphenidate) is taken, and the prefrontal cortex and parietal lobe may be displayed when ATX (atomoxetine) is taken. The brain region to be displayed depending on the conditions is not limited to this, and may change according to future research results, or may change according to the purpose of treatment. You may have the function to change the measurement position (especially right and left) displayed by left and right handed hand information. It is automatically determined whether there is a data acquisition history in the past, and when there is past data, a plurality of latest past data are displayed simultaneously. In particular, in determining the effect of drugs in attention deficit / hyperactivity disorder (Attention Deficit / ＤＳHyperactivityＴＲDisorder: ADHD), in addition to the evaluation scale of DSM-IV-TR scaled by behavioral observation of parents and teachers, Based on the index of medicinal efficacy judgment, for example, the temporal change of the brain function index and the temporal change of the treatment information are displayed simultaneously. In addition, although the example which acquires a brain function parameter | index by optical brain function measurement (optical topography etc.) was described here, not only this but the measuring method based on electromagnetic means, such as an electroencephalograph and a magnetoencephalograph, functional magnetic resonance What acquired based on the imaging method (fMRI) may be used.

Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. In the accompanying drawings, functionally identical elements may be denoted by the same numbers. The accompanying drawings show specific embodiments and implementation examples based on the principle of the present disclosure, but these are for the purpose of understanding the present disclosure and are not intended to limit the present disclosure in any way. Not used.

This embodiment has been described in sufficient detail for those skilled in the art to implement the present disclosure, but other implementations and forms are possible, without departing from the scope and spirit of the technical idea of the present disclosure. It is necessary to understand that the configuration and structure can be changed and various elements can be replaced. Therefore, the following description should not be interpreted as being limited to this.

Furthermore, the embodiment of the present disclosure may be implemented by software running on a general-purpose computer, or may be implemented by dedicated hardware or a combination of software and hardware.

In the following description, each information of the present disclosure will be described in a “table” format. However, the information does not necessarily have to be represented by a data structure using a table, and a data structure such as a list, DB (database), or queue. Or may be expressed in other ways. Therefore, “table”, “list”, “DB”, “queue”, etc. may be simply referred to as “information” to indicate that they do not depend on the data structure.

In addition, when explaining the contents of each information, the expressions “identification information”, “identifier”, “name”, “name”, “ID” can be used, and these can be replaced with each other. It is.

<Configuration of brain function index output device>
FIG. 1 is a diagram illustrating a schematic configuration of a brain function index output device (also referred to as a diagnosis assisting device or a diagnosis assisting system) 100 and peripheral devices according to an embodiment of the present disclosure.

The brain function index output device 100 inputs and receives various types of information and various types of data, and stores information and data acquired by the input unit 101 and processing results obtained by the calculation unit 109. Unit 102, an arithmetic unit (composed of a processor such as a CPU (Central Processing Unit)) 109 that calculates and processes various data based on a program, receives arithmetic results and data from the arithmetic unit 109, and displays And an output unit 103 for outputting calculation results and data to the display unit 106. In addition, as a peripheral device, a database 104 that holds subject (patient) information, treatment information of the subject, etc., and tasks executed by the patient (for example, attention task and inhibition task) are provided. A task unit (task controller) 105 that supplies the response time and correct answer rate of the person to the storage unit 102 as data, and measures a biological signal (for example, hemoglobin concentration change) in each part of the patient's brain before and after administration of the therapeutic agent, A measurement unit 107 that supplies a biological signal to the input unit 101, and a display unit 106 that simultaneously displays the calculation result, the result of the task by the subject, the detection result, the treatment information of the subject, and the like in parallel are prepared.

The database 104 stores information on each subject (patient), treatment information on each subject, and the like. The subject information includes a subject ID for identifying the subject, a hospital ID for identifying the hospital on which the subject is engaged, the surname of the subject, and the birthday of the subject. , Information such as the date the subject was examined and the gender of the subject. Treatment information includes the type of prescription drug, the type and dosage of the drug prescribed this time, the frequency of medication, the treatment history information (for example, the type and dosage of the drug administered in the past), and the past measurement results ( A biological signal obtained by measurement in the past). Information stored in the database 104 is provided to the calculation unit 109 via the input unit 101. The database 104 may be connected to the brain function index output device 100 via a network and installed remotely.

The measuring unit 107 is composed of, for example, a biological light measuring device (optical brain function measuring device, optical topography, etc.). The biological light measurement device converts a plurality of light sources, a plurality of photodetectors that detect light emitted from the light sources, and an inspection headset including a plurality of probes, and light detected by the photodetectors. And a main body, and measures and images a hemodynamic change in the living body (for example, hemoglobin concentration change in the cerebral cortex accompanying brain activity) using a change in the detected light amount. The biological signal measured by the measurement unit 107 is provided to the calculation unit 109 via the input unit 101.

The task unit 105 executes a task selected by a doctor or an operator (for example, one of an attention task and an inhibition task), and the task type and task The reaction time and the correct answer rate, which are the results of the execution, are stored in the storage unit 102.

The input unit 101 receives subject information and treatment information from the database 104, a biological signal from the measurement unit 107, and a task type and task execution result performed by the patient from the task unit 105, respectively. Deliver it or store it in the storage unit 102. The input unit 101 is also used as a means for a doctor or operator to input instructions and information to the brain function index output device 100. The input unit 101 corresponds to a keyboard, a mouse, a touch panel, a memory port such as a USB (Universal Serial Bus) port, a communication port such as a LAN (Local Area Network) port, and the like.

The storage unit 102 includes a memory, an HDD (Hard Disk Drive), and the like for storing information and data acquired via the input unit 101, calculation results by the calculation unit 109, and the like.

The calculation unit 109 reads various programs (for example, a program for executing processing corresponding to the flowcharts of FIGS. 5 and 10 described later) necessary for generating and outputting the inspection result display from a memory (not shown), appropriately executing, and executing The result is provided to the output unit 103.

The output unit 103 receives information and data stored in the storage unit 102 based on control by the calculation unit 109 and outputs the information and data to the display unit 106. The output unit 103 is, for example, a memory port such as a USB port, a display interface such as a D-Sub (D-subminiature) (VGA (Video Graphics Array)) connector, a DVI (Digital Visual Interface) connector, or a communication port such as a LAN port. Etc.

The display unit 106 displays data and information output from the output unit 103 on the screen. The display unit 106 may be a display or a printer.

As shown in FIG. 2, the brain function index output device 100 may be configured to include the task unit 105 and the measurement unit 107 inside.

<Processing sequence>
FIG. 3 is a diagram illustrating a sequence of processes executed in each component and each peripheral device of the brain function index output device 100 according to the embodiment of the present disclosure.

(I) Sequence 301
When a doctor or an operator designates a subject, the input unit 101 receives corresponding subject information from the database 104 and passes the subject information to the calculation unit 109. The subject information includes, for example, personal information such as the name, age, and sex of the corresponding subject, treatment history information of the corresponding subject, current treatment information (therapeutic drug, dosage, etc.), etc. included.

(Ii) Sequence 302
The input unit 101 inputs measurement settings to the measurement unit 107 based on instructions from a doctor or an operator. Here, the measurement setting is, for example, which subject's biological signal, and which part of the biological signal is to be acquired according to the task (task) and the type of medication. For example, in the case of an attention task (eg, Oddball task), the prefrontal cortex and parietal lobe of the subject, and when the subject (patient) medication is MPH, the prefrontal cortex and the subject medication are ATX In some cases, biological signals from the prefrontal cortex and parietal lobe are acquired. Thus, since the biological signal of the part which should be acquired changes according to the kind of subject and the kind of medication, it is preset in which part the biological signal is acquired. Note that this measurement setting may be performed automatically. For example, information (for example, information in a table format) indicating a correspondence relationship with a target task and a brain region corresponding to a target therapeutic drug is stored in advance in a memory, a storage unit 102, or the like in the measurement unit 107. . When the doctor or operator specifies the type of task to be executed or the type of medication, the measurement unit 107 may acquire appropriate part information corresponding to the specified content from the memory in the measurement unit 107 or the storage unit 102. good.

(Iii) Sequence 303
The measurement unit 107 measures, for example, a biological signal (for example, an optical topography signal) in a state in which a subject who has received medication is performing a given task (task) and a state in which the task is not performed, and an input unit The biological signal is provided via 101. Note that the biological signal is sent to the calculation unit 109 so that it can be identified which part of which subject.

(Iv) Sequence 304
Based on an instruction from a doctor or an operator, the input unit 101 provides analysis setting information to the calculation unit 109. Here, the analysis setting includes information on which subject performs what task, and information on what is displayed in an optical topography inspection report described later. In the case of the present embodiment, the region of interest (ROI) corresponding to the task is specified in the measurement setting, but information on the region of interest corresponding to the execution task may be included in the analysis setting. Further, the information on the attention site may be automatically set corresponding to the set task.

(V) Sequence 305
When the subject executes the task given from the task unit 105, the task unit 105 provides the operation unit 109 via the input unit 101 with, for example, the subject's response time or correct answer rate to the task as a task execution result. To do.

(Vi) Sequence 306
The calculation unit 109 receives information and data sent from the database 104, the measurement unit 107, and the task unit 105, and integrates them to generate diagnostic auxiliary information (integrated information: see FIG. 4), and the storage unit 102 Save to. When the data is stored in the storage unit 102, the calculation unit 109 includes a treatment information including a biological signal, a task execution result, and medication information in a subject (patient) ID included in the subject (patient) information. Associate all of By doing so, it becomes possible to accurately and easily acquire information necessary for displaying the inspection report (see FIG. 6 and FIG. 13).

(Vii) Sequence 307
In response to the data display instruction from the doctor or operator, the calculation unit 109 acquires diagnostic auxiliary information from the storage unit 102 based on the instruction. The data display instruction is input by operating the input unit 101 by a doctor or an operator. In accordance with the data display instruction, the calculation unit 109 stores the diagnosis auxiliary information associated with the information on the subject (patient) included in the instruction (for example, the subject ID and name) and the task information. Take out from.

(Viii) Sequence 308
The calculation unit 109 provides the diagnosis auxiliary information extracted from the storage unit 102 in the sequence 307 to the output unit 103 as output data.

(Ix) Sequence 309
The display unit 106 receives diagnostic auxiliary information to be displayed from the output unit 103 and displays it on the screen. How to display the acquired diagnostic auxiliary information on the screen is included in the analysis settings.

<Configuration of diagnostic assistance information>
FIG. 4 is a diagram illustrating a configuration example of the diagnostic auxiliary information 400 according to the embodiment of the present disclosure. As described above, the diagnostic auxiliary information 400 is generated by integrating the information and data acquired by the calculation unit 109 from the database 104, the measurement unit 107, and the task unit 105.

The diagnosis auxiliary information 400 includes, for example, a subject ID 401 for uniquely identifying and identifying the subject (patient), and a hospital ID 402 for uniquely identifying and identifying the hospital on which the subject is engaged. , A measurement ID 403 for uniquely identifying and identifying the measurement result of the subject, a date 404 for identifying the date on which the task and treatment were performed, the name 405 of the subject, and the subject Gender 406, the subject's birthday 407, treatment history information 408 about the subject, prescription information 409 indicating the therapeutic agent used in the current treatment, and administration of the therapeutic agent to be administered this time The amount 410, the task (task) 411 executed by the subject this time, and the biological signal 412 obtained by the current measurement (during the corresponding task by administering the corresponding therapeutic agent and taking a break) Biological signal between: Extract ed trial signal), the subject's response time 413 to the task, the subject's correct answer rate 414 to the task, a behavior observation result scale value 415 separately input by a doctor or operator, a diagnosis result 416, And a treatment 417 relating to a future therapy as configuration information. Furthermore, past measurement results (biological signals) may be included.

A subject (patient) can have only one subject ID, but may have multiple measurement IDs because it may perform multiple measurements.

Among the diagnosis auxiliary information 400, the subject ID 401, the hospital ID 402, the date 404, the name 405, the sex 406, the birthday 407, the treatment history 408, the prescription information 409, and the dosage 410 are information acquired from the database 104. . The measurement ID 403 and the biological signal 412 are information acquired from the measurement unit 107. Furthermore, the task 411, the reaction time 413, and the correct answer rate 414 are information acquired from the task unit 105.

The behavior observation result scale value (Rating scale) 415 represents the observation result based on the subjectivity of the parent or doctor as a score. Further, the diagnosis result 416 and the treatment 417 relating to the future treatment are information input by looking at the examination result display (optical topography examination report: see FIG. 6 and FIG. 13) displayed by the doctor. Therefore, this field is blank before the test result display (optical topography test report) is provided to the doctor. For the treatment 417 related to the future treatment, for example, a doctor can select and input from the pull-down menu 418.

<Inspection result display process>
FIG. 5 is a flowchart for describing processing until a test result report is displayed, which is executed by the brain function index output device 100 according to the embodiment of the present disclosure.

(I) Step 501
The calculation unit 109 sets the subject information and treatment information acquired from the database 104 in the diagnosis auxiliary information 400. Specifically, the calculation unit 109 stores the subject information such as the subject's ID, name, and gender from the database 104, the treatment history of the subject, and the treatments and dosages used this time. Information is acquired and input into each column of the subject ID 401, hospital ID 402, date 404, name 405, gender 406, birthday 407, treatment history 408, prescription information 409, and dose 410. When information is not held in a table format, these pieces of information are associated with each other (for example, information such as treatment history can be immediately acquired from the subject ID 401) and stored in the storage unit 102. .

(Ii) Step 502
The calculation unit 109 acquires analysis settings input by a doctor or an operator, and sets the analysis method of the acquired biological signal. In the analysis settings, information on the subject to be executed by the subject, a region to be noticed or region of interest (ROI), and conditions for displaying the test result (for example, display resolution, presence / absence of noise removal, past data) Whether or not to display, display setting information indicating a display mode of the inspection result, and the like). As described above, the calculation unit 109 may identify a notable part corresponding to the information based on the task information.

(Iii) Step 503
The calculation unit 109 acquires the result of the task performed by the subject from the task unit 105. The result of the task (task execution result) includes the type of task, the reaction time for the subject's task, the correct answer rate for the subject's task, and the like.

(Iv) Step 504
The calculation unit 109 acquires the biological signal of the subject from the measurement unit 107 and sets it in the diagnostic auxiliary information 400. More specifically, the calculation unit 109 acquires from the measurement unit 107 information on a biological signal and measurement date that are measurement results associated with the subject information (for example, a subject ID). And the calculating part 109 inputs a biological signal into the column of the biological signal 412 corresponding to the same subject ID and date. When the information is not held in a table format, the subject ID and the biological signal are associated with each other (for example, the biological signal can be immediately acquired from the subject ID) and stored in the storage unit 102. Become.

(V) Step 505
The calculation unit 109 analyzes the acquired biological signal. For example, the biological signal is filtered to remove noise, or statistical analysis is performed using the biological signal during the time when the subject is executing the task and when the subject is not executing the task. More specifically, regarding the statistical analysis, the calculation unit 109 calculates an average value of data at a specific time of the subject subject, for example, with respect to a result of a task executed a plurality of times. Moreover, the calculating part 109 calculates the difference value or ratio of the biosignal in the time slot | zone when the subject is performing the task, and the time slot | zone which is resting, for example. Further, the calculation unit 109 may calculate a difference value or a ratio of biological signals before and after administration of the therapeutic agent. The analysis result may be registered as one of the diagnostic auxiliary information 400.

(Vi) Step 506
The calculation unit 109 updates the subject information and treatment information in the database 104 after the subject executes the task and analyzes the obtained biological signal. When the subject subject is administered for the first time and the task is executed, the subject information and treatment information have not been registered in the database 104 before. Further, even if the subject subject has been previously administered and has performed the task, the current measurement results and treatment information are not yet registered in the database 104. Therefore, the calculation unit 109 registers newly obtained information and data in the database 104, and updates the subject information and the treatment information.

(Vii) Step 507
The calculation unit 109 determines whether or not the current measurement of the biological signal (optical brain function measurement signal) is the first time for the subject. Whether or not it is the first time can be determined based on whether or not the subject information is registered in the database 104 and is newly created. In the first case (Yes in step 507), the process proceeds to step 510. If it has been measured before (No in step 507), the process proceeds to step 508.

(Viii) Step 508
The calculation unit 109 determines whether or not the current display displays a plurality of data at the same time based on information on whether or not a plurality of data (past measurement data) simultaneous display settings are included in the input analysis settings. If the multiple data simultaneous display setting is selected (Yes in step 508), the process proceeds to step 509. If the multiple data simultaneous display setting is not set (No in step 508), the process proceeds to step 510.

(Ix) Step 509
The calculation unit 109 acquires past data (for example, previously measured biological signals and treatment information at that time) from the database 104 or the diagnostic auxiliary information 400.

(X) Step 510
The calculation unit 109 inputs the biological signal measured this time, the analysis result (for example, the calculated average value or difference value), the subject information, the biological signal measured in the past as necessary, and the doctor or operator. The displayed display setting information is provided to the display unit 106 via the output unit 103. Based on the display setting information, the display unit 106 lays out and displays biological signals, analysis results, subject information, and the like on the screen.

<Examination result display (default) configuration example>
FIG. 6 is a diagram showing an initial setting (default) configuration (example) 600 of the inspection result display (optical topography inspection report) according to the present embodiment.

The initial setting configuration 600 for displaying the examination result includes a subject information display area 601, a probe arrangement display area 602, a waveform display area 603, a statistical data display area 604, a comment description column 605, and a reference information display area 606. And a related person information display area 607 as configuration items. By configuring the test result display in such a configuration, it is possible to set a region display according to the problem and the treatment information, and to assist a doctor's diagnosis.

A subject information display area 601 includes a subject ID, a subject name, a subject's age, a subject's gender, a subject's dominant hand, a subject's date of birth, an examination date, and a subject. This is an area for displaying inspection tasks, inspection comments, and the like executed by the person. Furthermore, the subject information display area 601 includes a file selection button for reading subject information from a file. As will be described later with reference to FIG. 7, items displayed in the subject information display area 601 can be appropriately changed.

The probe arrangement display area 602 includes a plurality of channel displays 6021, a plurality of light source probes 6022, a plurality of light detection probes 6023, which are arranged on an illustration of the organ or organ (for example, the brain) of the person to be examined. Is an area for displaying. When the examination organ is the brain, as shown in FIG. 6, probe groups are arranged in the left and right brain portions. A plurality of channel displays 6021 indicate a part (region: channel) from which a biological signal (for example, a signal indicating increase or decrease of detection light) is acquired, and can be appropriately selected as a region of interest by a doctor or an operator (for example, the type of task) And the type of therapeutic agent administered). In this embodiment, 22 channels are set, and when the prefrontal cortex and parietal lobe are targeted, the channels to be noted may be determined in advance. The light source probe 6022 emits near-infrared light to measure the active state of the cerebral cortex. The light detection probe 6023 detects reflected light when near infrared light irradiated on the scalp returns to the scalp again. Since the hemoglobin concentration is known by the increase / decrease of the detection light, the blood volume in the cerebral cortex is known, and the active state of the brain can be measured. Note that an illustration (a method for displaying the face portion) may be superimposed on the MRI structure image to obtain a 3D display, or a dedicated image in which the state of probe mounting on the temporal region can be easily understood. In the initial setting, the number of light sources, the number of detectors, and the arrangement thereof are determined in advance. However, the doctor or the operator can display the number of light sources and the number of detectors displayed in the probe arrangement display area 602. May be set arbitrarily.

The waveform display area 603 is an area for displaying the waveform of the average value of the biological signal or the waveform of the difference average value in the selected area. In the initial setting (default), the waveform of the difference average value of the biological signals in region 1 is shown. The waveform displayed in the waveform display area 603 can be appropriately selected by a doctor or an operator. Although the waveform of the average value of the biological signal has been described here, the present invention is not limited to this, and the integral value, centroid value, inclination, predetermined waveform or correlation value between a plurality of predetermined periods of the biological signal, etc. are displayed. May be.

The statistical data display area 604 is an area showing the calculated statistical data in the selected area (channel). The subject performs the same task a plurality of times in one examination. Therefore, an average value of a plurality of biological signals acquired in one test is calculated and used as a measurement result of the corresponding test. In the statistical data display area 604, the value of S (Stimulation) indicates the average value of the biological signal measured during the task execution, and the value of B (Base line) is the biological signal measured during the break when the task is not executed. The average value is shown. S represents the measurement after medication in a day test (taken after measurement of B, at least 1.5 hours or more), and B represents the measurement before medication, and S represents the measurement before medication. The average value of the biological signal measured during the execution of the task may be shown, and the value of B may indicate the average value of the biological signal measured during the execution of the task before medication. B1 and S1 correspond to the first inspection, and B2 and S2 correspond to the second inspection. The difference average value indicates the average value of the difference between the biological signals before and after the execution of the task or the average value of the difference between the biological signals before and after the administration of the therapeutic agent in one examination. Although the average value of the difference between the biological signals has been described here, the present invention is not limited to this, and the average value of the correlation values and ratios between the plurality of biological signals, the difference value of the integral value of the biological signal, the difference value of the centroid value, the slope It may be a difference value.

The comment entry column 605 is an area for inputting a comment regarding a point or the like that the doctor or operator noticed by looking at the test result, and is initially blank.

The reference information display area 606 is an area for inputting reference information on the measurement implementation date. For example, medication information such as a therapeutic drug and its dosage by the subject is input. Further, the date and time when the read data of the subject is measured is automatically input. In addition, for example, MPH or ATX, which is an ADHD treatment drug, is registered in advance as an option of “reference information on measurement date”, and when selecting these items, “region to be noted when taking MPH” and “ATX taking” A function may be provided in which the “region of interest” is set automatically.

The related person information display area 607 is an area for displaying a doctor name in charge, an evaluator name, an inspector name, an inspection report date, and the like. Also, “Save”, “Print”, and “Close” icons are displayed in this area.

<Subject information display settings>
FIG. 7 is a diagram illustrating a configuration example of a display item selection screen for selecting a subject item to be displayed in the subject display area according to the present embodiment. The display item selection screen 700 is displayed in a pop-up when “Edit” is pressed on the initial setting screen of FIG. 6, for example.

In the display item selection screen 700, for example, the title of the test result report, the subject ID, the surname, the first name, the test comment, the age, the gender, the date of birth, the test subject, the test doctor, the evaluator, The examiner, report date, and hospital information can be selected. These items are examples and can be increased or decreased.

In the display item selection screen 700, a “return to initial value” button, an “OK” button, and a “cancel” button are displayed. If the “return to initial value” button is pressed, the setting is returned to the display item in the initial state. The display item selected by pressing the “OK” button becomes valid. In addition, if the “Cancel” button is pressed, all display items once selected are not selected, or the display item selection screen 700 is terminated without saving the setting contents. BR> B

<Inspection result display layout settings>
FIG. 8 is a diagram illustrating a configuration example of a layout setting screen for inspection result display according to the present embodiment. The layout setting screen 800 is displayed as a pop-up when “Report Screen Layout” is pressed on the initial setting screen of FIG. 6, for example.
The layout setting screen 800 includes a layout editable area display unit 801, a display content setting unit 802, and a cutoff setting unit 803 as configuration items.

The layout editable area display unit 801 indicates how the area from the subject information display area to the information display area for related parties is laid out on the screen. In the example of FIG. 8, the display contents cannot be changed as fixed areas for the subject information display area and the related person information display area, and the other areas can be set to arbitrary contents. The “large” area is provided below the subject information display area. Four areas from screen 1 to screen 4 are arranged between the “large” area and the information display area for related parties.

The content display setting unit 802 is a tool for the doctor or operator to select the content to be displayed in each area constituting the test result display. A doctor or an operator can use the content display setting unit 802 to input the type of report and also input the “large” area and the display contents of the screens 1 to 4. In FIG. 8, the input content can be selected by a pull-down menu, but a doctor or the like may directly input.

Cut-off setting unit 803 is a tool for setting a threshold value for indicating, for example, whether or not a therapeutic drug has an effect on a subject. If the amplitude value of the biological signal (average value or difference average value) is equal to or greater than the threshold value, it means that the therapeutic agent is effective for the subject, and if it is less than the threshold value, the effect is small. . By doing in this way, in the statistical data display area 604 in the test result report display, when the biological signal (average value or difference average value) is equal to or higher than the set threshold value, a data display form (for example, that can be understood) , The background of the corresponding column is displayed in red). The cut-off setting unit 803 is not limited to the effect of the therapeutic agent, and is used as a tool for setting the measurement result as a boundary value (threshold value) for dividing the measurement result into preset classifications (for example, classification A and classification B). It is also possible.

<Configuration of file selection screen>
FIG. 9 is a diagram showing a configuration example of a file selection screen according to the present embodiment. The file selection screen 900 is displayed, for example, by pressing the “file selection” icon on the initial startup screen (FIG. 6). By using this file selection screen 900, it is possible to select target data to display the inspection result. For example, when information to be searched is input to one or more items of a subject ID, surname, first name, gender, date of birth, and ID comment, data corresponding to the input item is displayed, and a doctor or operator Can select one of them.

As an assumed usage method, for example, after creating a test result display (test report) for the measurement data on the first day (at the first visit), the second day of the subject (two weeks after administration) The measurement data is added to the first day data to create an inspection report. Therefore, when the inspection report related to the measurement data on the second day is created, the data on the first day can be acquired using the file selection screen. By doing so, it is possible to automate the reference of past data and to expect effects such as reduction of the labor of doctors and operators. Moreover, the effect that the measurement data of multiple days can be compared easily can be expected.

<Region of interest (ROI) setting process>
FIG. 10 is a flowchart illustrating the region of interest (ROI) setting process according to the present embodiment.

(I) Step 1001
When the doctor or operator presses “display” on the initial setting screen (FIG. 6) using the input unit 101, the calculation unit 109 detects the press of “display” and displays the parameter setting screen 1100 shown in FIG. .

The parameter setting screen 1100 includes a display parameter setting unit 1101, an analysis parameter setting unit 1102, a region of interest setting button 1103, and a reanalysis button 1104. The display parameter setting unit 1101 is a tool for setting the waveform range of the biological signal to be displayed. In FIG. 11, the maximum value of hemoglobin concentration change is set to 0.5, and the minimum value is set to −0.5.

The analysis parameter setting unit 1102 is a tool for setting which time section of the biological signal is to be analyzed. In the analysis, for example, when a task is repeatedly presented, a time-sequential data is divided into task sections (blocks) and an averaging process is performed to extract a signal synchronized with the task. In addition, for example, when “task section” is selected, the time range (analysis section) in the block is automatically set to the task section set at the time of measurement by the measurement unit 107 in advance. Here, for example, a biological signal from 17 seconds to 38 seconds after the start of the measurement block is set as an analysis target. That is, in the case of “task section”, the analysis section is set as a fixed section. In addition, although not shown in the figure, if “all sections” is selected, all block sections are automatically set as analysis sections. If “any section” is selected, doctors and operators can freely set the analysis sections by entering numerical values. Can be done.

The region-of-interest setting button 1103 is a button for moving to the region-of-interest setting screen (FIG. 12) by pressing the button. An analysis target channel (region) can be set using the region of interest setting screen.

The re-analysis button 1104 is, for example, a button that is pressed when a parameter is changed and instructs execution of analysis again with the changed parameter.

(Ii) Step 1002
The calculation unit 109 acquires (receives) the setting of the graph range for displaying the biological signal waveform and the setting of the analysis target section set by the doctor or operator using the parameter setting screen of FIG. To reflect.

(Iii) Step 1003
The calculation unit 109 displays the light source and the detector on the illustration based on the information on the number of probe light sources and the number of detectors or probe arrangement separately set and input by a doctor or an operator. For example, the set light sources and detectors are arranged at equal intervals as much as possible.

(Iv) Step 1004
When the calculation unit 109 detects that the region of interest setting button 1103 has been pressed by a doctor or operator, for example, the calculation unit 109 pops up the region of interest setting screen 1200 shown in FIG.

The region of interest setting screen 1200 includes a region of interest (channel) selection unit 1201 and a region of interest registration unit 1202. Although the region of interest selection unit 1201 is shown so that three regions can be selected, it may be three or more. The region-of-interest setting unit 1201 is a tool for selecting a region to be set as an analysis target channel in the probe placement region 602. The region-of-interest registration unit 1202 is a tool for naming and registering combinations of regions 1 to 3 selected as analysis target channels. The number of regions registered as analysis target channels may vary depending on the therapeutic agent and the type of problem, and the three regions are not always registered as a set, and may be one or two.

(V) Step 1005
When the doctor or operator selects any one of the region buttons 1 to 3 to be set as the analysis target channel on the region-of-interest setting screen 1200, the calculation unit 109 arranges a plurality of probes and channels in the probe placement region 602. Displays an illustration of the organ (brain) or its surface. When a doctor or an operator sets a channel to be registered as the above-described selected region (any one of regions 1 to 3) on the illustration, for example, by a mouse (corresponding to the input unit 101) operation, the calculation unit 109 detects the setting and temporarily stores information on the position of the channel to be registered as the selected area in a memory (not shown). When such an operation is repeated and all the required areas are set as analysis target channels, the process proceeds to step 1006.

Note that, here, the analysis target channel is set by selecting one channel from the probe and channel arrangement displayed on the organ illustration, but this is not a limitation. For example, the analysis target channel may be set by displaying a screen for drawing the waveforms of all the set channels and allowing the doctor or operator to select the waveforms.

(Vi) Step 1006
When a doctor or an operator inputs a registered name of a combination of regions 1 to 3 to be set as an analysis target channel in the region of interest registration unit 1202 and presses a “save” button, the calculation unit 109 stores the combination of the regions, for example, a storage unit 102. By registering the combination of analysis target channels in this way, it is not necessary to set the analysis target channel again when performing the same inspection or creating another report, and easily set the same area. Since it can be set, it is very convenient for the user.

<Configuration example of customized inspection result display>
FIG. 13 is a diagram illustrating a configuration example of a test result display in which the initial test result display (see FIG. 6) is customized by a doctor or an operator. The inspection result display is customized by executing the operations described with reference to FIGS. 7 to 12 after the initial setting inspection result display (FIG. 6) is displayed. FIG. 13 is an example, and the layout and information displayed in each area differ depending on the selection by the doctor or operator. In the test result display shown in FIG. 13, the subject information, display parameters (axis range of hemoglobin change), and region of interest setting are customized.

In FIG. 13, a customized test result display 1300 includes, for example, a subject information display area 601, a probe placement display area 602, a waveform display area 603, a statistical data display area 604, a comment description column 605, The reference information display area 606 and the related person information display area 607 are included as configuration items.
As shown in FIG. 13, in the subject information display area 601, the setting is changed so as not to display the first and last names of the subject.

In the probe arrangement display area 602, the channel 10 is set as the area 1, the mark (1301) indicating the area 1 is displayed, the channel 6 is set as the area 2, and the mark (1302) indicating the area 2 is displayed. . Here, since an attention task (odd ball inspection) is performed as a task, two regions for the prefrontal cortex and parietal lobe are set as analysis target channels. In the probe arrangement display area 602, a channel (measurement position) display on the brain surface (MNI coordinate system or Talairach coordinate system) may be used. In this case, the measurement site to be displayed may be switched between left and right based on the dominant hand information of the subject. For example, when right-handed, the right part is displayed, and when left-handed, the left part is displayed. Thus, when different activities and reactions are expected in the left and right brain regions by the dominant hand, there is an effect that information useful for the doctor and the operator can be efficiently displayed.

In the waveform display area 603, the axial range of hemoglobin change is set from −0.10 to 0.10, and the difference average value waveform (difference waveform of oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration) in area 1 is displayed. Yes. Although the differential waveform is displayed here, the ratio value of the average value of the baseline period and the task execution period and the waveform of the ratio may be displayed by the selection of the doctor or the operator. Furthermore, information such as the temporal integration value of the waveform, the average value, the centroid value of the waveform calculated in a predetermined period, the slope of the waveform in a predetermined period, the correlation value with a predetermined waveform (for example, Hemodynamic response function: HRF), etc. You may display.

In the statistical data display area 604, the baseline period in the areas 1 and 2, the average value of the task execution period, and the difference average value that is the difference between them are displayed. If these values are equal to or higher than the cutoff value 803 input in FIG. 8, the corresponding values are displayed so that the background color changes. Here, information such as the temporal integration value of the waveform, the average value, the centroid value of the waveform calculated for a predetermined period, the slope of the waveform for a predetermined period, the correlation value with a predetermined waveform (for example, Hemodynamic response function: HRF), etc. May be displayed.

In the reference information display area 606, the measurement date and time of the data measured by the measurement unit 107 is automatically input. A doctor or an operator can input (selective input) information on a therapeutic agent and its dose and information on an execution task in correspondence with the measurement date and time. Note that when information on a therapeutic drug or an execution task is input as reference information, the analysis target channel may be automatically registered in response to the input.

<Modification of layout setting for inspection result display>
FIG. 14 is a diagram illustrating a configuration example of a layout setting screen for inspection result display according to a modification of the present embodiment. Similar to the layout setting screen 800, the layout setting screen 1400 is displayed as a pop-up when “report screen layout” is pressed on the initial setting screen of FIG.

The layout setting screen 1400 includes layout editable area display units 1401_1 and 1401_2, a display content setting unit 1402, and a parameter setting unit 1403 as configuration items.

The layout editable area display sections 1401_1 and 1401_2 indicate how the area from the subject information display area to the information display area for related parties is laid out on the screen. In the example of FIG. 14, the display contents cannot be changed as fixed areas for the subject information display area and the related person information display area, and the other areas can be set to arbitrary contents. The “large” area is provided below the subject information display area. Ten areas from the screen 1 to the screen 10 are arranged between the “large” area and the information display area for related parties.

The content display setting unit 1402 is a tool for the doctor or operator to select the content to be displayed in each area constituting the test result display. A doctor or an operator can use the content display setting unit 1402 to input the type of report and input the “large” region and the display contents of the screens 1 to 10. In FIG. 14, the input content can be selected by a pull-down menu, but a doctor or the like may directly input. Examples of screen types include region 1 waveform (difference), analysis range average value table, comments, reference information on the date of measurement, treatment information such as medication information, feature map, evaluation scale (for example, Rating Scale) , Region 2 waveform (difference), region 1 waveform (original), integrated value of the waveform etc., centroid value of the waveform etc., inclination of the waveform etc., correlation value between the waveform and another predetermined waveform, etc. Can be mentioned. In FIG. 14, two comment fields are set. For example, a comment input to the screen 3 is automatically reflected in the diagnosis result 416 of the diagnosis auxiliary information 400 (see FIG. 4) and input to the screen 8. The comment that has been made may be automatically reflected in the treatment 417 regarding the future treatment.

The parameter setting unit 1403 is, for example, a tool for setting a threshold value and a horizontal axis and a vertical axis of a feature amount map for indicating whether or not a therapeutic drug has an effect on a subject. If the amplitude value of the biological signal (average value or difference average value) is equal to or greater than the threshold value, it means that the therapeutic agent is effective for the subject, and if it is less than the threshold value, the effect is small. . By doing in this way, in the statistical data display area 604 in the test result report display, when the biological signal (average value or difference average value) is equal to or higher than the set threshold value, a data display form (for example, that can be understood) , The background of the corresponding column is displayed in red).

<Example of information displayed on each screen>
FIGS. 15 to 18 are diagrams for explaining examples of information that can be displayed on the layout editable area display units 1401_1 and 1401_2 of the layout setting screen 1400 of the inspection result display. Each information (tool) listed below is generated by the calculation unit 109 using information necessary for display.

(I) ADHD rating scale (Rating Scale)
FIG. 15 is a diagram showing a display example of an ADHD evaluation scale graph 1501 and an ADHD evaluation scale table 1502 that can be displayed on the examination result display screen. Both may be displayed in the inspection result display, or either one may be displayed.

The ADHD evaluation scale is a score value obtained by observing the subject by the subject's parent or the teacher in charge of the school (teacher) and answering the question items from a subjective viewpoint. The ADHD evaluation is performed on, for example, carelessness, hyperactivity / impulse, and total (total behavior including carelessness, hyperactivity / impulse). The ADHD evaluation scale obtained in this way is stored in the database 104 in association with the subject, and may be acquired by the calculation unit 109 as necessary, or may be input separately from the input unit 101.

Recording of each of B1 (Base line 1), S2 (Stimulation 2), and S3 (Stimulation 3) is performed by the following method. For example, Rating Scale (first time) is performed at the time of B1 measurement (the days before and after the measurement), and this is recorded in the “B1” item of the table. Also, Rating Scale (second time) is performed at the time of S2 measurement (the days before and after), and is recorded in the “S2” item of the table. Further, Rating Scaling (third time) is performed at the time of S3 measurement (the days before and after), and is recorded in the “S3” item of the table.

Since the brain function measurement signals (average values of biological signals, etc.) are displayed in the other screen areas as described above, such biological signals and time series information of the evaluation scale (eg Rating Scale) are displayed simultaneously. By doing so, it is possible to assist a doctor's comprehensive judgment regarding medical conditions and the like.

(Ii) Feature Quantity Map FIG. 16 is a diagram showing a display example of a feature quantity map 1600 that can be displayed on the examination result display screen.

In ADHD inspection (go / no-go (inhibition task: Inhibition task) and oddball (attention task)), in addition to Rating Scale charts and tables (Figure 15), the average of optical topography measurements with RatingRScale There is a case in which a feature amount map that displays a relation with a value in a scatter diagram is displayed. This feature map 1600 is a tool for determining the correlation between a subjective evaluation score value (Rating Scale) and an objective biological signal (the average value of hemoglobin concentration measurement values in the analysis section). Here, a feature amount map is generated that shows the correlation between the evaluation score value and the average value of the measured values of hemoglobin concentration in the analysis interval, but other values such as the peak value of the biological signal and the variance value are used as objective indicators. , Integral value, centroid value, slope, correlation value, etc.

By presenting such a feature amount map 1600, it is possible to easily compare the score value of the evaluation scale with the biological signal, and the evaluator (doctor or operator) can easily grasp the correlation between the two.

(Iii) Radar Chart FIG. 17 is a diagram showing a display example of a radar chart 1700 that can be displayed on the inspection result display screen. In FIG. 17, taking a therapeutic drug, performing a given task, and performing a rating scale (score evaluation) by an evaluator (parent or doctor) as a set, this test is repeated three times. Results are shown.

The radar chart 1700 is a tool for displaying a plurality of parameters related to drug efficacy and assisting the evaluator in determining whether the currently used therapeutic drug is effective for the subject. In the radar chart 1700, for example, an axis is arranged so as to indicate that the improvement is made toward the outside of the chart. It is also possible to display the area of the polygon corresponding to each measurement time as an index.

The parameters displayed in the radar chart 1700 include, for example, a hemoglobin change signal difference value (difference before and after taking a therapeutic drug) 1701, a correlation coefficient 1702 between blocks, an inverse number 1703 of a reaction time, a correct answer rate 1704, Rating Scale (reciprocal) 1705 can be mentioned. Of course, other parameters may be included.

The hemoglobin change signal difference value 1701 indicates the difference value between the hemoglobin concentration value (biological signal) measured before taking the therapeutic drug and the hemoglobin concentration value (biological signal) measured before taking the therapeutic drug. The larger the value, the better.

The correlation coefficient 1702 between blocks is that a subject performs a plurality of tasks in one examination (for example, the same task (attention task) is performed six times), but each time is regarded as one block. This is information indicating whether or not there is a correlation between each block. If a waveform of a similar biological signal is measured in each block, it is determined that the correlation is high, and if it is dissimilar, the correlation is small. The correlation is higher when there is a medicinal effect. For example, the correlation value can be obtained by comparing the biological signals on the time axis to obtain a difference and calculating the sum of the squares of the difference. Alternatively, correlation coefficients between arbitrary two waveforms of six measured waveforms may be calculated in all possible combinations and averaged may be used as the correlation value.

The reciprocal 1703 of the reaction time is a value obtained by taking the reciprocal of the reaction time obtained when the subject executes the task. The smaller the reaction time is, the better the result is for the task, so the reciprocal is taken here.
The correct answer rate 1704 is a value of the correct answer rate obtained when the subject executes the task. The higher the correct answer rate, the better.

Rating Scale (reciprocal) 1705 is a value obtained by taking the reciprocal of the score value of subjective evaluation by the evaluator (doctor or operator). The higher the score value, the stronger the tendency of ADHD (the symptom improvement is not seen), and the smaller the value, the more the symptom improvement is seen. Therefore, the reciprocal is taken.

By presenting such a radar chart 1700, it is possible to easily grasp the condition of the subject at the time of each examination, and to prompt a doctor or operator to make a comprehensive medicinal effect determination.

(Iv) Relationship between change in task correct answer rate and average reaction time FIG. 18 shows changes (increase) in task correct answer rate obtained when the subject executed the task and the response spent in answering the task. It is a figure (graph) which shows the relationship (example) with time.

In the graph of FIG. 18, by repeating examinations, the correct answer rate increases and the average reaction time decreases. Therefore, it can be seen from this graph that when the improvement by the therapeutic agent is seen, the correct response rate increases and the average reaction time decreases.

Thus, by displaying the increase in the correct answer rate and average response time in multiple measurements, it is possible to visualize the treatment effect from the behavioral evaluation, and by displaying these simultaneously with the treatment information, Effective information presentation can be realized.

<Summary>
(I) In the embodiment of the present disclosure, the brain function index output device (diagnosis auxiliary system) includes information (ID, first name, dominant hand, date of birth, etc.) on the subject (subject) from the database, Acquire treatment information (therapeutic drug and its dose, administration date, etc.). The brain function index output device also acquires a biological signal (optical topography data indicating a change in hemoglobin concentration in the blood vessels of the brain) in a predetermined part (brain) of the subject of the subject measured by the measurement unit. The brain function index output device generates integrated information (diagnosis auxiliary information) by integrating information on the subject, treatment information, and biological signals, and examines a plurality of types of information included in the integrated information. A display process for simultaneously displaying the result on the screen of the display device is executed. In this way, by displaying the biological signal and the treatment information of the subject in parallel, doctors and operators do not have to bother to acquire the treatment information separately and match the displayed biological signal. It becomes possible to evaluate the symptom improvement effect by treatment more effectively and quantitatively. In addition, this makes it possible to assist comprehensive diagnosis.

The brain function index output device further obtains the execution result (reaction time and correct answer rate) of the subject with respect to a predetermined task (attention task or suppression task) from the task unit, and integrates the execution result with the integrated information (diagnosis assistance) Information) to generate a test result display. By including the subject's reaction to the task as display information in this way, the symptom improvement effect by treatment such as medication can be more objectively evaluated.

If there are past test results of the subject, the biometric signal acquired in the past test and the execution result of the past task may be acquired, and the past biosignal and the execution result of the task may be included in the integrated information Good. This makes it possible to easily compare past and present data. Further, information that enables comparison between the execution result of the task acquired in the current examination and the execution result of the task acquired in the past examination may be generated and included in the examination result display (FIG. 18). . Furthermore, the biosignal acquired in the past examination of the subject and the execution result of the past task are obtained, and the input of the evaluation result of the behavior observation for the subject during the current examination and the past examination is accepted. The information (FIG. 16) indicating the correlation between the biological signal acquired in the current examination and the biological signal acquired in the previous examination and the evaluation result in the current examination and the past examination is generated and included in the examination result display. May be. By providing various information in this way, it is possible to assist so that a more objective and effective diagnosis can be performed.

When generating a test result display, a doctor or an operator can instruct the display layout and display contents. In this manner, by generating a customized test result display, information can be provided in a display form that is easy for a doctor or the like to diagnose.

Also, when providing a biological signal, the measurement data itself is not provided, but statistical data generated by statistical processing (calculating an average or difference average) of the biological signal is provided. When raw data is provided, data variation may lead to misdiagnosis, but statistical processing can encourage more appropriate diagnosis by a doctor or the like.

In the test result display, when the statistical data is displayed numerically, the display form of the statistical data may be changed based on a threshold value set and inputted by a doctor or the like. Thereby, it becomes possible to easily determine whether or not there is a therapeutic effect.

Conventionally, doctors and operators had to determine from which part of the brain to obtain a biological signal, depending on the subject executed by the subject and the type of therapeutic drug to be taken, in this embodiment, A brain region may be automatically selected according to the problem and the type of therapeutic agent, an analysis target channel (region) may be set, and a biological signal may be acquired from the channel. By doing in this way, the biological signal of an appropriate site | part can be acquired reliably according to a subject and the kind of therapeutic agent. Therefore, it is possible to provide effective diagnosis assistance even for doctors who have relatively little experience.

(Ii) In this embodiment, a diagnosis assistance system is described by taking a mental illness such as ADHD as an example. However, the application of the idea of the present disclosure is not limited to a psychiatric illness, and can be used for diagnosis of various diseases. It is applicable to.

(Iii) The present disclosure can also be realized by a program code of software that realizes the functions of the embodiments. In this case, a storage medium in which the program code is recorded is provided to the system or apparatus, and the computer (or CPU or MPU) of the system or apparatus reads the program code stored in the storage medium. In this case, the program code itself read from the storage medium realizes the functions of the above-described embodiments, and the program code itself and the storage medium storing the program code constitute the present disclosure. As a storage medium for supplying such program code, for example, a flexible disk, CD-ROM, DVD-ROM, hard disk, optical disk, magneto-optical disk, CD-R, magnetic tape, nonvolatile memory card, ROM Etc. are used.

Also, based on the instruction of the program code, an OS (operating system) running on the computer performs part or all of the actual processing, and the functions of the above-described embodiments are realized by the processing. May be. Further, after the program code read from the storage medium is written in the memory on the computer, the computer CPU or the like performs part or all of the actual processing based on the instruction of the program code. Thus, the functions of the above-described embodiments may be realized.

Further, by distributing the program code of the software that realizes the functions of the embodiment via a network, the program code is stored in a storage means such as a hard disk or a memory of a system or apparatus, or a storage medium such as a CD-RW or CD-R And the computer (or CPU or MPU) of the system or apparatus may read and execute the program code stored in the storage means or the storage medium when used.

Finally, it should be understood that the processes and techniques described herein are not inherently related to any particular equipment, and can be implemented by any suitable combination of components. Further, various types of devices for general purpose can be used in accordance with the teachings described herein. It may prove useful to build a dedicated device to perform the method steps described herein. Various inventions can be formed by appropriately combining a plurality of constituent elements disclosed in the embodiments. For example, some components may be deleted from all the components shown in the embodiment. Furthermore, constituent elements over different embodiments may be appropriately combined. Although this disclosure has been described with reference to specific examples, these are in all respects illustrative rather than restrictive. Those skilled in the art will recognize that there are numerous combinations of hardware, software, and firmware that are suitable to implement the present disclosure. For example, the described software can be implemented in a wide range of programs or script languages such as assembler, C / C ++, perl, shell, PHP, Java (registered trademark).

Furthermore, in the above-described embodiment, control lines and information lines are those that are considered necessary for the explanation, and not all control lines and information lines on the product are necessarily shown. All the components may be connected to each other.

In addition, other implementations of the present disclosure will become apparent to those skilled in the art from consideration of the specification and embodiments of the disclosure disclosed herein. The specification and specific examples are merely exemplary, and the scope and spirit of the disclosure is set forth in the claims that follow.

100 brain function index output device, 101 input unit, 102 storage unit, 103 output unit, 104 database, 105 task unit, 106 display unit, 107 measurement unit, 109 calculation unit, 400 diagnostic auxiliary information, 600 initial setting of test result display Configuration, 601 Subject information display area, 602 Probe placement display area, 6021 Multiple channel display, 6022 Multiple light source probes, 6023 Multiple light detection probes, 603 Waveform display area, 604 Statistical data display area, 605 Comment entry column 606, reference information display area, 607, information display area of related parties, 700, display item selection screen, 800 layout setting screen, 801 layout editable area display section, 802 display content setting section, 03 Cutoff setting section, 900 File selection screen, 1100 Parameter setting screen, 1101 Display parameter setting section, 1102 Analysis parameter setting section, 1103 Interest area, Setting button, 1104 Reanalysis button, 1200 Interest area setting screen, 1201 Interest area ( Channel) selection part, 1202 area of interest registration part, 1300 customized inspection result display, 1301 mark indicating area 1, 1302 mark indicating area 2, 1400 layout setting screen, 1401_1 layout editable area display part, 1401_2 layout editable Area display section, 1402 Content display setting section, 1403 Parameter setting section, 1501 ADHD evaluation scale graph, 1502 ADHD evaluation scale table 1,600 feature map, 1700 radar chart

Claims (17)

1. A diagnostic assistance system for assisting diagnosis of a symptom of a subject,
   A processor that loads and executes various programs necessary for diagnosis assistance;
   An information storage device for storing a processing result generated by the processor;
   The processor is
   Information about the subject provided from a database, processing for obtaining treatment information for the subject,
   Processing for acquiring the biological signal from a measurement unit that measures the biological signal at a predetermined part of the subject;
   Information on the subject, the treatment information, and the biological signal are integrated to generate integrated information, and a plurality of types of information included in the integrated information are simultaneously displayed on the screen of the display device as a test result display. Display processing for
   Execute a diagnostic assistance system.
2. In claim 1,
   The processor further executes a process of acquiring the execution result from a task unit that outputs the execution result of the subject with respect to a predetermined task,
   In the display process, the processor includes the execution result in the integrated information.
3. In claim 2,
   The predetermined site is the brain of the subject,
   The treatment information is a diagnostic assistance system including information on a type of a psychiatric drug taken by the subject and a dosage of the drug.
4. In claim 3,
   The measurement unit includes one or more light irradiation units;
   One or a plurality of light detection units for detecting the light irradiated by the light irradiation unit,
   The diagnostic assistance system, wherein the biological signal is a hemodynamic change.
5. In claim 1,
   The said processor further changes the setting in the said test result display based on the instruction | indication input about a display layout and display content, and produces | generates the customized test result display.
6. In claim 1,
   The processor further performs a process of calculating at least one of a difference value, an average value, an integral value, a centroid value, an inclination value, and a correlation value using one or a plurality of predetermined period signals in the biological signal. A diagnostic assistance system for generating statistical data and including the statistical data in the integrated information.
7. In claim 3,
   The diagnostic support system, wherein the processor selects the brain region according to the type of the task executed by the subject or the treatment information, and includes the biological signal at the brain region in the integrated information.
8. In claim 5,
   The processor further assists in diagnosing the brain region of the subject displayed in the examination result display according to dominant hand information included in the information on the subject.
9. In claim 7,
   The processor includes, in the integrated information, the biological signal measured at the first brain region when the task is a suppression task, and is measured at the second brain region when the task is an attention task. A diagnostic assistance system that includes the biological signal in the integrated information.
10. In claim 9,
    The diagnosis assisting system, wherein the first brain part is a forehead part and the second brain part is a forehead part and a parietal lobe.
11. In claim 6,
    The said processor is a diagnostic assistance system which produces | generates the said test result display by changing the display form of the said statistical data regarding the said biomedical signal based on the threshold value input by setting.
12. In claim 2,
    The processor further acquires the biological signal acquired in the past examination of the subject and the execution result of the past problem from the database, and the past biological signal and the execution result of the problem are the integrated information. And a diagnostic assistance system for generating the test result display.
13. In claim 12,
    The processor displays the test result display that makes it possible to compare the biomedical signal acquired in the current examination and the execution result of the task with the biomedical signal acquired in the past test and the execution result of the task. Generate diagnostic assistance system.
14. In claim 12,
    The said diagnosis processor is a diagnostic assistance system which produces | generates the said test result display which enables the comparison with the execution result of the said task acquired in this test | inspection, and the execution result of the said task acquired in the past test | inspection.
15. In claim 2,
    The processor further acquires the biological signal acquired in the past examination of the subject and the execution result of the past problem from the database, and the behavior for the subject during the current examination and the past examination. Accepts input of observation evaluation results,
    The processor generates information indicating a correlation between the biological signal acquired in the current examination and the biological signal acquired in the past examination, and the evaluation result in the current examination and the past examination, A diagnostic assistance system to be included in the test result display.
16. A diagnostic auxiliary information display method in a diagnostic auxiliary system for assisting diagnosis of a symptom of a subject,
    The diagnostic assistance system includes a database that stores information on the subject and treatment information for the subject, a measurement unit that measures a biological signal at a predetermined part of the subject, and various programs necessary for diagnostic assistance A processor that reads and executes the information, an information storage device that stores a processing result generated by the processor, and a display device that displays the processing result on a screen,
    The diagnostic auxiliary information display method includes:
    The processor obtains information about the subject and treatment information for the subject from the database;
    The processor acquires the biological signal from the measurement unit;
    Test results for the processor to generate integrated information by integrating the information about the subject, the treatment information, and the biological signal, and simultaneously display a plurality of types of information included in the integrated information Generating a display and outputting to the display device;
    The display device displays the inspection result display on the screen;
    A method for displaying diagnostic auxiliary information.
17. In claim 16,
    The predetermined site is the brain of the subject,
    The treatment information includes information on the type of drug for mental illness taken by the subject and the dosage of the drug,
    The diagnostic auxiliary information display method further includes:
    The processor acquires the execution result from a task unit that outputs the execution result of the subject for a predetermined task;
    Including the execution result in the integrated information when the processor generates the inspection result display;
    A method for displaying diagnostic auxiliary information.

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