WO2017019959A1 - Formulations et procédés pour la récupération après une chirurgie de la colonne vertébrale - Google Patents

Formulations et procédés pour la récupération après une chirurgie de la colonne vertébrale Download PDF

Info

Publication number
WO2017019959A1
WO2017019959A1 PCT/US2016/044714 US2016044714W WO2017019959A1 WO 2017019959 A1 WO2017019959 A1 WO 2017019959A1 US 2016044714 W US2016044714 W US 2016044714W WO 2017019959 A1 WO2017019959 A1 WO 2017019959A1
Authority
WO
WIPO (PCT)
Prior art keywords
dexamethasone
composition
patient
bone
spinal
Prior art date
Application number
PCT/US2016/044714
Other languages
English (en)
Inventor
James Rutkowski
Original Assignee
Clarion Research Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clarion Research Group filed Critical Clarion Research Group
Publication of WO2017019959A1 publication Critical patent/WO2017019959A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

La présente invention concerne des procédés et une composition pour l'amélioration de la récupération après une lésion médullaire ou la chirurgie de la colonne vertébrale ayant un impact sur l'os. La composition comprend un matériau d'échafaudage comprenant une matrice de collagène de type 1 et une forme cristalline non céramique d'hydroxyapatite, et de la dexaméthasone ou un sel pharmaceutiquement acceptable de celle-ci ou une hormone glucocorticoïde dissoute dans une solution saline. Un avantage de la présente invention est une vitesse accrue de la croissance osseuse et de la nouvelle croissance osseuse.
PCT/US2016/044714 2015-07-30 2016-07-29 Formulations et procédés pour la récupération après une chirurgie de la colonne vertébrale WO2017019959A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562198945P 2015-07-30 2015-07-30
US62/198,945 2015-07-30

Publications (1)

Publication Number Publication Date
WO2017019959A1 true WO2017019959A1 (fr) 2017-02-02

Family

ID=57885055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/044714 WO2017019959A1 (fr) 2015-07-30 2016-07-29 Formulations et procédés pour la récupération après une chirurgie de la colonne vertébrale

Country Status (1)

Country Link
WO (1) WO2017019959A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077267A1 (en) * 2005-10-03 2007-04-05 Sdgi Holdings, Inc. Bioactive composite implants
WO2013043529A1 (fr) * 2011-09-19 2013-03-28 Emory University Activation de la voie de la protéine morphogénétique osseuse, compositions pour ossification et méthodes associées
US8431148B2 (en) * 2007-03-08 2013-04-30 Warsaw Orthopedic, Inc. Bone void filler
US20140134211A1 (en) * 2008-05-30 2014-05-15 James Louis Rutkowski Formulations and Methods for Recovery From Dental Surgery
US20140294985A1 (en) * 2011-10-21 2014-10-02 University Of Maryland,Baltimore Bone pastes comprising biofunctionalized calcium phosphate cements with enhanced cell functions for bone repair
US20140303744A1 (en) * 2002-06-13 2014-10-09 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20140308332A1 (en) * 2010-12-13 2014-10-16 Biomimetic Therapeutics, Llc Compositions and Methods for Spine Fusion Procedures

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140303744A1 (en) * 2002-06-13 2014-10-09 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20070077267A1 (en) * 2005-10-03 2007-04-05 Sdgi Holdings, Inc. Bioactive composite implants
US8431148B2 (en) * 2007-03-08 2013-04-30 Warsaw Orthopedic, Inc. Bone void filler
US20140134211A1 (en) * 2008-05-30 2014-05-15 James Louis Rutkowski Formulations and Methods for Recovery From Dental Surgery
US20140308332A1 (en) * 2010-12-13 2014-10-16 Biomimetic Therapeutics, Llc Compositions and Methods for Spine Fusion Procedures
WO2013043529A1 (fr) * 2011-09-19 2013-03-28 Emory University Activation de la voie de la protéine morphogénétique osseuse, compositions pour ossification et méthodes associées
US20140294985A1 (en) * 2011-10-21 2014-10-02 University Of Maryland,Baltimore Bone pastes comprising biofunctionalized calcium phosphate cements with enhanced cell functions for bone repair

Similar Documents

Publication Publication Date Title
Al-Ahmady et al. Combining autologous bone marrow mononuclear cells seeded on collagen sponge with Nano Hydroxyapatite, and platelet-rich fibrin: Reporting a novel strategy for alveolar cleft bone regeneration
US10987450B2 (en) Lyophilized moldable implants containing an oxysterol
JP2018533414A (ja) オキシステロールの薬物負荷を有するインプラント及びその使用法
EP3697459B1 (fr) Substitut de greffe osseuse autologue
BR112013021369B1 (pt) Implante e sistema de formação de um implante para promover crescimento ósseo
Hoekstra et al. The in vivo performance of CaP/PLGA composites with varied PLGA microsphere sizes and inorganic compositions
JP2021151525A (ja) オキシステロールを含有するインプラントおよびその使用方法
US20070036766A1 (en) Tissue graft composition comprising autologous bone marrow and purified autologous thrombin
Chakar et al. Bone formation with deproteinized bovine bone mineral or biphasic calcium phosphate in the presence of autologous platelet lysate: comparative investigation in rabbit
Moheb et al. Mineralized plasmatic matrix to enhance the bone grafting technique
Gheno et al. The effectiveness of the use of xenogeneic bone blocks mixed with autologous Concentrated Growth Factors (CGF) in bone regeneration techniques: A case series
RU2360663C1 (ru) Гель для регенерации костной ткани
Vadalà et al. Autologous bone marrow concentrate combined with platelet-rich plasma enhance bone allograft potential to induce spinal fusion
CN106310357B (zh) 一种骨填充黏合剂及其制备方法及应用
WO2017019959A1 (fr) Formulations et procédés pour la récupération après une chirurgie de la colonne vertébrale
Al-Ashmawy et al. Effect of platelet-rich fibrin on the regeneration capacity of bone marrow aspirate in alveolar cleft grafting (clinical and radiographic study)
Baldan et al. Atrophic maxilla reconstruction with fresh frozen allograft bone, titanium mesh, and platelet-rich fibrin: Case report
US9511076B2 (en) Formulations and methods for recovery from dental surgery
EP2711012A1 (fr) Formulations et procédés pour la récupération de chirurgie dentaire
US20120195938A1 (en) Formulations and methods for recovery from dental surgery
EP3144017A1 (fr) Matériau de remplissage à base de hydroxyapatite enrichi au plasma et son procédé de formation
Kadry et al. Evaluation of collagen versus platelet rich fibrin membrane on the osteogenic potential of bone marrow aspirate concentrate for lateral Sinus floor augmentation: A Randomized Clinical Trial.
El Halawani Evaluation of Mineralized Plasmatic Matrix Versus Platelet Rich Plasma in Deficient Anterior Maxillary Alveolar Ridge: A Randomized Controlled Clinical Trial
Chenchev et al. Socket preservation with PRF as a sole grafting material–clinical and histological evaluation. Case report
Parusheva et al. Histomorphological Study of Regenerative Processes in Post-extraction Alveolar Sockets after Application of a Combined Preservation Method

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16831411

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16831411

Country of ref document: EP

Kind code of ref document: A1