WO2017013007A1

WO2017013007A1 - Combination container system

Info

Publication number: WO2017013007A1
Application number: PCT/EP2016/066888
Authority: WO
Inventors: Martin Folger; Daniela Stahl
Original assignee: Boehringer Ingelheim Vetmedica Gmbh
Priority date: 2015-07-23
Filing date: 2016-07-15
Publication date: 2017-01-26
Also published as: DE212016000148U1

Abstract

The invention relates to a combination container system (1) for receiving and storing pharmaceutical products, in particular of human and veterinary medicine, in particular tablets, pills, dragees, comprising a main container (2) having a receiving chamber (4) with at least one opening (3) for removing and/or filling pharmaceutical products in a first manner, having a central closure device (6) for optionally closing or releasing the opening (3) of the main container (2), comprising at least one additional container (7) having a receiving chamber (9) with an opening (8) for removing and/or filling pharmaceutical products in a second manner, and having a closure element (10) for optionally closing or releasing the opening (8) of an individual receiving chamber (9) of the additional container (7), wherein, in the closed position of the central closure device (6), the additional container (7) is accommodated by the receiving chamber (3) of the main container (2) and is connected to the central closure device (6), and the central closure device (6) has first connection elements (11) for cooperating with first connection elements (12) on the main container (2). The invention is characterised in that the central closure device (3) associated with the main container (2) has a safety device, in particular a child-safety device (13). Preferably, the additional container (7) additionally has a safety device, in particular a child-safety device, in the closure element (10).

Description

COMBINATION TANK SYSTEM

The invention relates to a combination container system for receiving and storing pharmaceutical products, in particular human and veterinary medicine, in particular tablets, pills, dragees, comprising a main container with a, at least one opening for the removal and / or filling of pharmaceutical products of the first kind having receiving chamber , with a central closure device for selectively closing or releasing the opening of the main container, with at least one additional container having a receiving opening for the removal and / or filling of pharmaceutical products second receiving chamber and a closure element for selectively closing or releasing the opening of a single receiving chamber of the additional container , wherein the additional container is received in the closed position of the central closure device of the receiving chamber of the main container and is connected to the central closure device and the central closure device has first connection elements for interacting with first connection elements on the main container.

In veterinary medicine, it is common to tailor the dosage of veterinary drugs to the body weight of the individual animal to be treated. Especially with pets such as dogs and cats, the administration of a drug by the pet owner. For solid dosage forms such as tablets, they must be divided relatively frequently and the resulting tablet parts administered at different times. The tablet fragments are then placed back in the container to the undivided tablets and are often difficult to find when desired removal. Although, depending on the design of the closure system, both the tablets in undivided form and the fragments are stored and accessible in the same way, but a targeted removal of fragments is not possible. An unwanted access, for example, for small children is not sure avoidable.

Although separate receiving chambers for products of different properties are generally known from the prior art, but meet the requirements of the storage of human and veterinary products is insufficient.

Systems with separate receiving chambers can be characterized by the connection of these to the respective container, as described in US 3931891 or the closure device.

The documents CA 2252215, DE 20311503 Ul, US 2004/0007595 describe embodiments of closure devices of a container with integrated in these chambers or chamber systems, which allow the storage of tablet parts and are accessible from the outside regardless of access to the container. The tablet parts are exposed in these not necessarily the same environmental conditions as in the container to be closed, furthermore, the possibilities of integrating chambers in closure devices with regard to the dimensioning of these are limited. Since the accessibility to the receiving chambers is given by a separate closure regardless of the actual accessibility to be closed container, separate security measures are required to prevent unwanted access. Versions with such integrated externally accessible chambers and child safety are known for example from US 2009/0127157 AI.

Systems with receiving chambers which can be coupled to the closure device of a container by gluing are known from US 2002/0139709 A1 and by insertion from US 2013/0152515 A1, CN 2611306 Y and CA 2761211.

However, all have the disadvantage that they are insufficient for the application for the storage of human and veterinary medicine, since either the sizing of the receiving chambers limits are set or additional measures to protect against unwanted access are not or only with additional effort. The publication US 2011/0278195 AI discloses a generic combination container system for receiving and storing pharmaceutical products with a main container and with an additional container. To protect against unwanted access to the main container is a safety device between the provided for closing the main container provided cap and the main container. The additional container is detachably connectable to the cap and can be absorbed by this. The invention has for its object to further develop a system for storing pharmaceutical products, in particular for human and veterinary medicine to the effect that the disadvantages mentioned are avoided. The system should be suitable for the separate storage and storage of pharmaceutical products of the first and second kind, whereby the products of the first and second kind should be stored under the same environmental conditions as far as possible. The access to the products of the first and second kind should be reliably secured by simple means against unwanted removal by means of a simply constructed and also actuatable with low actuation force child protection. The receptacle for second-type products should also be suitable for a large number of possible sizes of products and for larger quantities.

The solution according to the invention is characterized by the features of claims 1 and 14. Advantageous embodiments are described in the subclaims. A combination container system according to the invention for receiving and storing pharmaceutical products, in particular human and veterinary medicine, in particular tablets, pills, dragees, comprising a main container with a receiving chamber having at least one opening for the removal and / or filling of pharmaceutical products of the first type central closure means for selectively closing or releasing the opening of the main container, comprising at least one auxiliary container having a receiving chamber for dispensing and / or filling pharmaceutical products of the second type, and a closure member for selectively closing or releasing the opening of a single receiving chamber of the auxiliary container, wherein the Additional container is received in the closed position of the central locking device of the receiving chamber of the main container and connected to the central locking device and the ze ntrale closure device has first connecting elements for cooperation with first connecting elements on the main container, wherein the central closure device associated with the main container has a child safety device, characterized in that

that the central locking device has a child safety device in the form of a safety device, which is designed and arranged to be suitable to spend the first connecting elements in an engaged position with the first connecting elements on the main container or to decouple; the central closure device has a first cap-like element for enclosing the region having the opening on the main container, wherein the first connecting elements for connection to the main container, which are designed with play to the first connection elements on the main container, are arranged on a partial area of its inner periphery Securing device comprises a second cap-like element, which is circumferentially surrounding the first cap-like element and at a portion of its inner circumference means for coupling with complementary means on the first cap-like element relative to each other in the longitudinal direction while bridging the play in the connection between the first connecting elements on closure device and main container.

Pharmaceutical products of the first and second kind may in particular be pharmaceutical products which differ from one another at least with regard to one of the following quantities, the enumeration being not exhaustive: composition, consistency, formulation, size, geometry, dosage, chemical composition , Active ingredients. In a particularly advantageous application, the combination container system thereby serves to receive and store pharmaceutical products that are identical in terms of the active ingredients, such as tablets, which, however, are at least divisible for metering the amount to be administered. Pharmaceutical products of the first kind in this case represent the whole tablets, for example whole tablets in the range of 50 mg to 4 g. Pharmaceutical products of the second type are tablet parts, in particular tablet halves and / or tablet quarters. These can be stored by the separation provided by the additional container in an advantageous manner spatially safe separated from the whole tablets and are therefore easy to locate, handle and remove. Damage resulting in the dosage due to abrasion or breakage in the interaction, in particular contacting with in the Recording chamber of the main container can affect recorded tablets are thus avoided. By providing at least one additional container, which is accommodated in the receiving chamber for the pharmaceutical products of the first kind, the pharmaceutical products of the second kind are stored in the immediate vicinity and thus under the same environmental conditions, in particular temperature, humidity as the pharmaceutical products of the first kind.

The closed position of the central closure device of the main container is understood to be the functional position of the closure device, in which the closure device closes the at least one opening of the main container. The "open" function position is characterized by the removal or removal of the closure device from the main container or the release of the access to the receiving chamber, which, analogously to the access to the receiving chamber in the auxiliary container, also applies to the closure element and the auxiliary container.

Under a child safety is in particular a device to understand that makes it possible to make the closable with this recording chamber for children inaccessible.

The coupling, in particular connection of the additional container to the central closure device offers the advantage of a fixed allocation of the storage chamber for the products of the second type with respect to the main container. In a preferred embodiment, the additional container can be inserted and removed again into the central closure device.

The proposed child safety in the central closure device with the main container, which makes access to the main chamber difficult, while simultaneously accommodating the additional container in the receiving chamber of the main container safe storage for the pharmaceutical products of the second kind without any additional measures required. The central locking device makes difficult access to both the main and the child safety Additional container without additional measures on the additional container, since the latter is accessible only after opening the main container and decrease the closure device.

In order to realize the parental control, the central closure device and preferably also the closure element or elements of the one or more additional containers has a securing device. This is embodied and arranged at the central locking device in such a way as to place the first connecting elements in an engaged position with the first connecting elements on the main container and out again. The embodiment is characterized in that a clearance is provided in the connection via the first connecting elements between the main container and the central locking device, which clearance is overcome by the securing device for the purpose of loosening or connecting. For this purpose, the central closure device has a first cap-like element for enclosing the region which has the opening on the main container, wherein the first connecting elements, which are designed with play to the first connection elements on the main container, are arranged on a partial region of its inner circumference. The safety device is designed and arranged so that the game is canceled only when operated in one direction. For this purpose, this has a second, the first cap-like element in the circumferential direction enclosing cap-like element which is coupled to the first cap-like element via coupling elements to the effect that upon relative movement of the second cap-like element, the first cap-like element in particular in the longitudinal direction by canceling the game in the compound is taken to the main container and thus the connecting elements are brought into operative connection. In this case, the second cap-like element is coupled in this functional position with the first cap-like element for realizing a non-rotatable connection and thus allows upon actuation in the circumferential direction, a release of the closure device. The inventive design of the child safety device reliably and reliably prevents unwanted access, in particular for children, due to the required superimposition or sequence of movements for releasing the closure device. A design of child safety with regard to a required size of the required operating force to cancel can then be omitted. Advantageously, the safety device can be designed in such a way that it is possible to loosen the locking device by releasing the securing device with knowledge of the required sequence of movements, even with little effort, and thus also by persons who can only exert low actuating forces due to impairments in the hand area is. As the longitudinal direction of the cap-like element is to be understood in particular a direction perpendicular to the circumferential direction thereof.

In a preferred embodiment, the closure element of the additional container also has a child safety device. This is particularly advantageous if the additional container is not firmly connected to the central closure device, but in the central locking device can be inserted and removed again.

Under a child safety is in particular a device to understand that makes it possible to make the closable with this recording chamber for children inaccessible. The closure devices or closure elements are for this purpose in particular designed such that for opening various movements of the respective receiving chamber occlusive element are required, which may also be superimposed on each other and are not easily performed by a small child without instructions. The child safety device can be designed to be integrated in the closure device or closure elements or else separate measures are also conceivable.

In a structurally very simple to implement, preferably only one additional container is provided. For more complex requirements requiring separate storage of multiple product types, such as the storage of tablet halves and quarters, it is also conceivable to integrate two or more receiving chambers in one or more additional containers. These are then also received in the closed position of the central closure device of the receiving chamber of the main container and connected to the central locking system. The individual receiving chambers can be designed to be closable via a closure element which is jointly assigned to a plurality of receiving chambers or via closure elements assigned in each case to individual receiving chambers.

With regard to the design of the individual additional container, there are a number of possibilities. This can be formed according to a first basic version of a separate container which is detachably connectable to the closure device. In In a second basic embodiment, the additional container can be formed at least partially by the central closure device in functional concentration.

The first basic version has the advantage that the additional container can be removed from the container system if necessary and is also interchangeable. The additional container and the second type of product accommodated therein can thus also be kept separate from the products of the first type, if required. In particular, in this embodiment, the closure element of the additional container preferably has a child safety. Also, for example, additional containers with different volumes for a combination container ystem be offered interchangeable in combination with a main container and a central closure device The main container can thus be used universally and distributed with a central locking device with and free of an additional container.

In contrast, the second basic version offers the advantage that no separate connection devices between additional container and closure device are to be provided and the closure device is a central component of the additional container, which is thus captive.

In order to be able to create a connection between a single additional container and the central closure device in the first basic embodiment, second connecting elements for realizing an operative connection with connecting elements on the additional container are provided on the central closure device. Depending on the design and arrangement of the individual opening for filling and / or removal of pharmaceutical products of the second type with respect to the central closure device in the closed position and the formation of the closure element, different variants are possible.

If the closure of the additional container takes place via a separate, separate closure element, the connecting elements are in the region outside the opening of the receiving chamber of the container to be closed by the closure element Additional container arranged on this. The arrangement can be carried out in the region of the bottom or a side wall of the additional container.

If, however, according to a second advantageous alternative variant, the closure element is formed by the central closure device, the second connection elements are provided in the region of the opening to be closed and are formed in function concentration by the first connection elements which can be brought into engagement with the connection elements on the central closure device. In this advantageous embodiment with a high component function concentration, the closure element associated with a receiving chamber of an additional container is thus formed by the central closure device, wherein the opening to be closed of the individual receiving chamber to be closed is directed in the closed position of the additional container to an inner peripheral region of the central closure device. For this purpose, a component, in particular the central closure device is assigned at the same time the task of the closure for the receiving chambers of the main container and the additional container.

In an advantageous development, a single receiving chamber of the additional container has a further opening for filling the receiving chamber with pharmaceutical products of the second kind in the closed position of the additional container, which is provided in the wall of the additional container and by a smaller dimension than that for filling and / or removal provided opening, preferably a dimensioning, which corresponds to a male predefined maximum size of a product of the second kind and a predefined game is characterized. This allows insertion of, for example, a tablet fragment into the receiving chamber on the additional container without having to open it, but prevented due to the dimensioning falling out of this.

With regard to the structural design of the first and / or second connecting elements on closure device, closure element, main container and auxiliary container there are a plurality of possibilities. These are designed as connecting elements for implementing at least one of the following types of connection or a combination of these: non-positive connection

positive-locking connection.

In an advantageous embodiment, the connection between a single auxiliary container and the central closure device is designed as a compound selected from the group of the following compounds:

clamp connection

press connection

bayonet connection

- screw connection

Locking connection.

This applies analogously also for the connection between the additional container and the closure element.

For captive connection of the closure element of the additional container, the closure element is preferably articulated on the additional container via a hinge connection or an articulated connection. The materials of the main tank and auxiliary tank and the shape are not particularly limited. The containers can be made of plastics or glass. Glass is widely used due to its transparency, and compatibility with many pharmaceutical formulations. Closure device and closure elements are preferably made of plastic.

Preferably, the containers - main and auxiliary containers - are each made in a hollow cylinder, wherein the cross-sectional geometry, in particular surfaces can vary in the longitudinal direction. The solution according to the invention is explained below with reference to figures. It details the following: FIGS. 1 a to 1 c illustrate, in a schematized and highly simplified representation, the FIG

Basic structure and the basic function of a combination according to the invention

Container system in the closed position;

Figures 2a and 2b show exemplary embodiments of additional containers according to Figure la with different types of closures;

FIG. 2c illustrates, by way of example, connecting elements on the closure element and

Additional container for selectively releasing or closing it;

Figures 3a to 3b show by way of example possible embodiments of additional containers

Additional features;

Figure 4 illustrates the integral formation of an additional container with the central

Closure device;

FIG. 5 shows a perspective view of a separate additional container;

Figure 6 shows a particularly advantageous embodiment of the combination container system in an axial section.

For identical components, the same reference numerals are used in all figures.

Figures la to lc illustrate in schematic highly simplified representation of the basic structure and the basic function of a combination container system 1 according to the invention in the closed position in a section of an axial section. The individual functional components are reproduced by way of example and are not limited to the illustrated variant with regard to the structural design. This comprises a main container 2 with a, at least one opening 3 for the removal and / or filling of pharmaceutical products of the first kind having receiving chamber 4. The opening 3 is arranged in an end region of the main container 2. The main container 2 is here preferably hollow cylindrical with an opening 3 having, and tapering along a longitudinal axis L of the hollow cylindrical main container 2 extending formed end portion 5 executed. The enclosed by a wall of the main container 2 interior forms the at least one receiving chamber 4. For selectively closing or releasing the opening 3, a central closure device 6 is provided. The combination container system 1 further comprises at least one additional container 7 with at least one second opening 8 for the removal and / or filling of pharmaceutical products Art receiving receiving chamber 9 and a closure member 10 for selectively closing or releasing the opening of a single receiving chamber 9 of the additional container 7, wherein the auxiliary container 7 is received in the closed position of the central closure device 6 of the receiving chamber 4 of the main container 2 and connected to the central closure device 6 , For connection, the central closure device 6 has first connection elements 11 for interacting with first connection elements 12 on the main container 2. The connecting elements 11 and 12 are indicated only schematically. This is assigned a safety device 13 for the realization of a child safety device. With regard to the specific design of the child safety device 13 and the first connecting elements, there are a variety of possibilities. Conceivable for the first connecting elements 11 both positive and non-positive connection elements. The safety device 13 makes it possible for the connecting elements not to be in engagement with one another in a functional state in which the closure of the receiving chamber 4 must be ensured and if the opening 3 is desired when the safety device 13 is activated or deactivated in operative connection with the release device 6 from the main container 2. The main container 2 may be made of different materials. Preferably, plastics or glass will be used. As a material for the closure device, for example, a plastic is used.

The figure la illustrates a first embodiment, in which the additional container 7 is designed as a separate, ie individually handled container. This is detachably connectable to the closure device 6, connected in the illustrated case. The additional container 7 is closed by a closure element 10, preferably with an additional, not shown here in detail safety device, preferably child safety lock. The connection is made via first connecting elements 14 on the additional container 7 and first connecting elements 15 on the closure element 10, which can be brought into operative connection with one another to form a detachable connection. The detachable connection between the additional container 7 and the central closure device 6 is realized via second connecting elements 16 of the closure device 6 and second connecting elements 17 on the additional container 7. The connections that can be generated with the individual connecting elements 11, 14 on the central closure device 6, the main container 2, the additional container 7 and the closure element 10 can each be non-positive or positive or a combination of these.

The additional container 7 is arranged in the closed position of the combination container system 1 in the illustrated embodiment with the opening 8 in the vertical direction downwards and away from the inner circumference of a cap-shaped central locking device 6. The additional container 7 is connected to the central closure device 6 in the region of a wall region, in this case its container bottom, via a non-positive and / or positive connection. This has to second connecting elements 16 which are engageable with second connecting elements 17 on the outer circumference of the additional container 7 in operative connection. The individual connecting elements 11, 12, 14, 15, 16, 17 can be designed in various ways. These can form force as well as positive connections depending on the training.

In the closed position of the additional container 7 is received by the receiving chamber 4 of the main container 2. The additional container 7 is dimensioned in the illustrated embodiment such that it is formed extending over the extension of the closure device 6 in the longitudinal direction of the longitudinal axis L viewed over the extension of the closure device 6 extending. With respect to FIG. 1a, FIG. 1b illustrates a design of a first basic embodiment with a separate additional container 7, in which the central closure device 6 forms the closure element 10 of the additional container 7 in functional concentration. The realization of the connection between the central closure device 6 and the main container 2 is designed analogously to FIG. 1 a with safety device 13. The additional container 7 is also here in analogy to Figure la releasably connected to the central closure device 6. The connection is realized via the operative connection of second connecting elements 17 in the region of the opening 8 on the additional container 7 and second connecting elements 16 on the central locking device 6, wherein the function of the second connecting elements 17 on the additional container is taken over by the first connecting elements 14 at these for connection to the closure element 10 in functional concentration. The central closure device 6 is also designed like a cap and the connection with the additional container 7 is provided on the inner circumference of the closure device 6.

Figure lc illustrates a second basic embodiment with at least partially integrated in the central closure device 6 or integral with this additional container 7. That wall portions of the additional container 7 are formed by the central closure device 6 with. This is formed in this embodiment, for example, on a cap-like element of the closure device 6 in the manufacture with. When the main container 2 is closed, the opening 8 of the additional container 7 is preferably here oriented in the direction of the receiving chamber 4 and thus directed away from the closure device 6. The closing element 10, which is preferably provided with an additional securing device, in particular a child safety device, can be brought into operative connection with first connecting elements 14 in the region of the opening 8 on the additional container 7 for the purpose of closing via first connecting elements 15. The figures la to lc serve to illustrate the possible basic configurations without claim to reproduction of the detailed structural design of the individual components. These may be formed modified. Decisive is the connection of the additional container 7 to the central closure device 6, the inclusion in the closed position of the closure device 6 relative to the additional container in the receiving chamber 4, whereby the securing device 13 acts in the connection between the main container 2 and central locking device 6 for the additional container and in 2a and 2b show examples of possible training variants of closure elements 10 for the additional container 7. The auxiliary container 7 is formed as a hollow cylindrical element whose wall describes an interior space in the form of the receiving chamber 9 , This has an opening 8 for filling and / or Removal of pharmaceutical products, which is closable via the closure element 10. The closure element 10 is embodied here as a closure cap, ie has an area encompassing the auxiliary container 7 in the region of the opening 8 in the circumferential direction. In this case, the first connecting elements 15 for realizing a connection to the additional container 7 are formed on an inner peripheral region of the region of the closure element 10 which surrounds the additional container in the closed position. These are brought to the realization of the closed position of the additional container 7 with arranged in the region of the opening 8 surrounding wall first closure elements 14 on the additional container 7 in operative connection.

In contrast, FIG. 2b shows a design of the additional container 7 with closure element 10, in which the connection between these in the region of the opening 8 is formed on the inner circumference of the wall regions of the additional container which describe the opening 8. The closure element 10 is designed to extend in this case with a portion in the receiving chamber 9. And, viewed transversely to the longitudinal direction of the additional container 7, it is preferably flush with the outer circumference of the additional container 7. The formation of the connecting elements 14, 15 to additional container 7 and closure element 10 can also be force and / or positive fit here.

Find as non-positive versions especially screw use, a positive connection can be formed for example via a snap-in connection, which is at least acting in one direction, preferably acting in two directions. One possibility for realizing a form fit is reproduced in FIG. 2c on the basis of cutouts from the wall regions of closure element 10 and additional container carrying the connecting elements. Here, for example, the closure element 10 shown on the right has projections 19 on its connecting element-carrying region, which can engage in recesses 20 on the additional container 7. A section of the wall region of the additional container 7 is reproduced on the left in FIG. 2c. The recesses 20 on the additional container 7 extend in the opening 8 enclosing wall in Insertion direction of the closure element 10 and are formed for locking with a region which is aligned at an angle to the guide direction of the closure element 10, preferably vertically. For locking a latching recess 21 is provided here, which is provided at the vertically aligned portion of the recess. This type of connection is particularly suitable for additional container 7, which are received in the receiving chamber 4 of the main container 2 aligned opening 8 of this, ie with the closure member 10 facing down. In this case, in the closed position between additional container 7 and closure element 10, the projection 19 in the recess 21. To open or close the additional container is a superimposed movement of two movements in and against the longitudinal direction of the additional container and in the circumferential direction required.

Figures 3a to 3c show exemplary advantageous developments of an additional container 7. Figures 3a and 3c show training with additional receiving opening 22 for introducing the pharmaceutical products of the second kind, in particular tablet fragments in the additional container 7 free from the need to solve the closure element 10. The individual receiving opening 22 in FIG. 3 a extends through the wall as far as the receiving chamber 9 and is dimensioned such that it is suitable for receiving fragments of a predefined maximum size, but does not let out any fragments present in the receiving chamber 9. The cut for a predefined maximum size receiving opening 22 is dimensioned such that an insertion of tablet fragments with little play can be done to this. The removal of the tablet fragments is then via the release of the closure element 10th

FIG. 3 a shows a design with such a receiving opening 22.

The figure 3b illustrates an example of an embodiment with two receiving chambers 9.1, 9.2 on the additional container 7. Each receiving chamber 9.1, 9.2 here own closure element 10.1, 10.2 assigned. Conceivable, but not shown, is also a version with a two receiving chambers 9.1, 9.2 jointly associated closure element 10. Figure 3b shows an embodiment free of additional Receiving openings, while Figure 3c shows an embodiment of an additional container 7 with differently dimensioned receiving chambers 9.1, 9.2 for different products of the second kind, for example, different tablet fragment sizes, each with a closure element 10.1, 10.2 are closed and wherein each of the receiving chambers 9.1, 9.2 via a receiving opening 22.1 , 22.2. The receiving openings 22.1, 22.2 are also dimensioned here with regard to the different sizes of tablet fragments to be received by the individual receiving chambers 9.1, 9.2. FIG. 4 shows by way of example a closure device 6 with integrated additional container 7 in the open position of the additional container 7 in an axial section. Visible are the first connecting elements 11 on an inner peripheral region of the central closure device 6, the additional container 7 formed on the inner circumference and the closure element 10 which is preferably provided with a safety device, preferably a child safety device, which is hinged to the additional container 7 via a hinge connection 23 and of the illustrated one opened position by pivoting and positive engagement or adhesion with the auxiliary container 7, in particular the wall areas in the region of the opening 8 can be moved into the closed position. Shown are also a tablet fragment 24 and the insertion direction into the receiving chamber 9 by means of arrow.

Figure 5 shows a perspective view of an additional container 7 in the closed position and embodiment of the closure element 10 with articulated connection to the additional container 7. Visible are also provided in the bottom region of the additional container 7 second connecting elements 17 in the form of a circumferential groove, with second connecting elements 16 in Form of engaging in these projections on the central locking device 6, not shown, can be brought into operative connection. 6 shows a detail of an axial section of a particularly advantageous embodiment of a combination container system 1. The auxiliary container 7 is as shown in Figure 5 reproduced as a separate container and second connecting elements 17 in the form of a circumferential groove with second Connecting elements 16 in the form of engaging in these projections on the central closure device 6 in operative connection. The central closure device is formed as a cap-like unit of a first cap 25 and a second cap 26 enclosing the first cap in the circumferential direction. The first cap 25 carries at an inner peripheral portion the second connecting elements 16 of the closure device 6 for connection to the auxiliary container 7, the first connecting elements 11 of the closure device 6, which engage with first connecting elements 12 on the main container 2 in the closed position with clearance and closing and Loosening with these over the safety device 13 can be brought into operative connection. The safety device 13 acts as a coupling device and comprises the second cap 26 and provided thereon means for coupling with the first cap 25 in relative movement of the second cap 26 relative to the first cap 25 in the longitudinal direction to each other, wherein in this movement, the first cap 25 in the for Solving required functional position relative to the main container 2 is spent by overcoming the game in the connection between the first connecting means 11 and 12 of the closure device 3 and the main container 2. The coupling device thus acts only in the longitudinal direction, not in the circumferential direction of the caps 25, 26. The means for coupling are formed here by positive driving elements 27 and 28, which are arranged on the outer circumference of the first cap 25 and inner circumference of the second cap 26 and in the closed position the central closure device 6 allow a relative movement in the circumferential direction between cap 25 and 26. Between the first and second cap, a rear part device 29 is further provided which is designed to be supporting in the form of a simple spring element on the inner circumference of the second cap 26 and the outer circumference of the first cap 27.

The invention includes aspects disclosed in the following sentences which form part of the description:

sentences

1. Combination container system (1) for receiving and storing pharmaceutical products, in particular human and veterinary medicine, in particular tablets, pills, dragees, comprising a main container (2) with a receiving chamber (4) having at least one opening (3) for dispensing and / or filling pharmaceutical products of the first type, with a central closure device (6) for selectively closing or releasing the opening (3) of the main container (2), with at least one additional container (7) with a, an opening (8) for the removal and / or filling of pharmaceutical products of the second type having receiving chamber (9) and a closure element (10) for selectively closing or releasing the opening (8) of a single receiving chamber (9) of the additional container (7), wherein the additional container (7) is received in the closed position of the central closure device (6) of the receiving chamber (3) of the main container (2) and with the central Locking device (6) is connected and the central locking device (6) first connecting elements (11) for cooperation with Having first connecting elements (12) on the main container (2), characterized in that the main container (2) associated with the central locking device (3) has a securing device, in particular child safety device (13).

Combination container system (1) according to sentence 1, characterized in that at least two or more receiving chambers (9.1, 9.2) are provided for receiving pharmaceutical products of the second kind, which are arranged in one or more additional containers (7), which via a A plurality of receiving chambers (9, 9.1, 9.2) together associated closure element (10) or each individual receiving chambers (9, 9.1, 9.2) associated closure elements (10, 10.1, 10.2) are closable, wherein the single closure element (10, 10.1, 10.2 ) has first connecting elements (15) which can be brought into operative connection with first connecting elements (14) on the additional container (7).

Combination container system (1) according to sentence 1 or 2, characterized in that the additional container (7) in the closure element (10) additionally also a securing device, in particular child safety has. Combination container system (1) according to one of the aforementioned sentences, characterized in that the additional container (7) is designed as a separate container which is detachably connectable to the closure device (6).

Combination container system (1) according to sentence 4, characterized in that at the central locking device (6) second connecting elements (16) for realizing an operative connection with second connecting elements (17) on the additional container (7) are provided.

Combination container system (1) according to sentence 5, characterized in that the individual receiving chamber (9, 9.1, 9.2) of the additional container (7) via a separate closure element (10, 10.1, 10.2) is closable and the second connecting elements (17) on Additional container outside the region of the opening of the enclosed by this receiving chamber (9, 9.1, 9.2) are arranged, wherein the second connecting elements (17) are provided on the additional container (7) in the region of a bottom or a side wall.

Combination container system (1) according to one of the sentences 1 to 3, characterized in that the additional container (7) is at least partially integral with a component of the closure device (6), one for filling and / or removal of pharmaceutical products of the second kind provided opening (8, 8.1, 8.2) via a separate closure element (10, 10.1, 10.2) can be closed.

Combination container system (1) according to sentence 5 or 6, characterized in that a receiving chamber (9, 9.1, 9.2) of an additional container (7) associated closure element of the central closure device (6) is formed, wherein the opening to be closed (8 , 8.1, 8.2) of the individual receiving chamber (9.1, 9.2) to be closed in the closed position of the additional container to an inner peripheral region of the central closure device (6) is directed and the second connecting elements (17) on the additional container for realizing a detachable connection with the central closure device ( 6) from the first Connecting elements (14) on the additional container (7) for realizing operative connection with the closure device (6) are formed.

Combination container system (1) according to one of the sentences 1 to 8, characterized in that a single receiving chamber (9, 9.1, 9.2) of the additional container (7) has a further receiving opening (27) for filling the receiving chamber (9, 9.1, 9.2) having pharmaceutical products of the second kind in the closed position of the additional container (7), which is provided in the wall of the additional container (7) and provided by a smaller dimensioning than the filling and / or removal opening provided (8, 8.1, 8.2) of the respective Receiving chamber (9, 9.1, 9.2), preferably a dimensioning, which corresponds to a male predefined maximum size of a product of the second kind and a predefined game is characterized. 10. Combination container system (1) according to one of the sentences 1 to 9, characterized in that the first and / or second connecting elements (11, 12, 14, 15, 16, 17) on the central closure device (6), closure element ( 10, 10.1, 10.2), main container (2) and additional container (7) are designed as connecting elements for realizing at least one of the following types of connection or a combination thereof:

non-positive connection

positive-locking connection

Combination container system according to sentence 10, characterized in that the connection between a single auxiliary container (7) and the central closure device (6) is designed as a compound selected from the group of the following compounds:

clamp connection

press connection

bayonet connection

screw

locking connection 12. combination container system (1) according to sentence 10 or 11, characterized in that the connection between the additional container (7) and the closure element (6, 10, 10.1, 10.2) is designed as a compound selected from the group of compounds mentioned below :

clamp connection

press connection

bayonet connection

screw

locking connection

Combination container system (1) according to one of the sentences 10 to 12, characterized in that the closure element (10, 10.1, 10.2) is articulated on the additional container (7) via a hinge connection (23) or an articulated connection. 14. Combination container system (1) according to one of the sentences 1 to 13, characterized in that the central closure device (6) has a securing device (13) which is designed and arranged to be suitable, the first connecting elements (11 ) in an engaged position with the first connecting elements (12) on the main container (2) to spend or decouple.

15. Combination container system (1) according to sentence 14, characterized in that the central closure device (6) has a first cap-like element (25) for enclosing the opening (3) on the main container (2) having region, wherein at a portion from the inner circumference of the first

Connecting elements (11) are arranged for connection to the main container (2), which are executed with play to the first connecting elements (12) on the main container (2) and the securing device (13) comprises a second cap-like element (26), which the first Cap-like element (25) is arranged circumferentially enclosing and at a portion of his

Inner peripheral means for coupling with complementary means on the first cap-like element (26) relative to each other in the longitudinal direction while bridging the game in the connection between the first Connecting elements (11, 12) on closure device (6) and main container (2).

Use of a combination container system (1) according to one of the sentences 1 to 15 for the reception of pharmaceutical products of the first and second type of human and veterinary medicine.

reference numeral

1 combination container system

2 main tanks

3 Opening of the receiving chamber on the main container

4 receiving chamber

5 end area

6 central locking device

7 additional container

8 opening

9, 9.1, 9.2 Storage chamber Additional tank

10, 10.1, 10.2 closure element, preferably with additional safety device /

childlock

11 first connecting elements to central locking device

12 first connecting elements main tank

13 Safety device / child safety lock

14 first connecting elements additional container

15 first connecting elements closure element

16 second connecting elements to a central locking device

17 second connecting elements to additional container

19 projections

20 recesses

21 recess

22, 22.1, 22.2 receiving openings

23 hinge connection

24 tablet fragment

25 cap

26 cap

27 driving elements

28 driving elements

29 rear part device

L longitudinal axis

Claims

claims

Combination container system (1) for receiving and storing pharmaceutical products, in particular human and veterinary medicine, in particular tablets, pills, dragees, comprising a main container (2) with one, at least one opening (3) for the removal and / or filling of pharmaceutical products first receiving chamber (4), with a central closure device (6) for selectively closing or releasing the opening (3) of the main container (2), with at least one additional container (7) with one, an opening (8) for removal and / or filling of pharmaceutical products of the second kind having receiving chamber (9) and a closure element (10) for selectively closing or releasing the opening (8) of a single receiving chamber (9) of the additional container (7), wherein the additional container (7) in the closed position of the central closure device (6) is received by the receiving chamber (3) of the main container (2) and with the centra 6) and the central closure device (6) has first connecting elements (11) for interacting with first connecting elements (12) on the main container (2), the central closure device (3) associated with the main container (2) being a securing device , in particular parental control (13), characterized

in that the central locking device (6) has a securing device (13) which is designed and arranged to be suitable for transferring or connecting the first connecting elements (11) into an engaged position with the first connecting elements (12) on the main container (2) decouple;

the central closure device (6) has a first cap-like element (25) for enclosing the region having the opening (3) on the main container (2), the first connecting elements (11) being connected to the main container at a partial region of its inner circumference (11). 2) are arranged, which are executed with play to the first connecting elements (12) on the main container (2) and the securing device (13) comprises a second cap-like element (26), which surrounds the first cap-like element (25) circumferentially and at a portion of its inner circumference means for coupling with complementary means on the first cap-like element (26) relative to each other in the longitudinal direction, including bridging the clearance in the connection between the first connecting elements (11, 12) on the closure device (6) and the main container (2).

Combination container system (1) according to claim 1, characterized in that at least two or more receiving chambers (9.1, 9.2) are provided for receiving pharmaceutical products of the second kind, which are arranged in one or more additional containers (7), which via a A plurality of receiving chambers (9, 9.1, 9.2) together associated closure element (10) or each individual receiving chambers (9, 9.1, 9.2) associated closure elements (10, 10.1, 10.2) are closable, wherein the single closure element (10, 10.1, 10.2 ) has first connecting elements (15) which can be brought into operative connection with first connecting elements (14) on the additional container (7).

Combination container system (1) according to claim 1 or 2, characterized in that the additional container (7) in the closure element (10) additionally also has a securing device, in particular child safety device.

Combination container system (1) according to one of the preceding claims, characterized in that the additional container (7) is designed as a separate container which is releasably connectable to the closure device (6).

Combination container system (1) according to claim 4, characterized in that at the central closure device (6) second connecting elements (16) for realizing an operative connection with second connecting elements (17) on the additional container (7) are provided. Combination container system (1) according to claim 5, characterized in that the individual receiving chamber (9, 9.1, 9.2) of the additional container (7) via a separate closure element (10, 10.1, 10.2) is closable and the second connecting elements (17) on Additional container outside the region of the opening of the enclosed by this receiving chamber (9, 9.1, 9.2) are arranged, wherein the second connecting elements (17) are provided on the additional container (7) in the region of a bottom or a side wall.

Combination container system (1) according to one of claims 1 to 3, characterized in that the additional container (7) is at least partially integral with a component of the closure device (6), one for filling and / or removal of pharmaceutical products of the second kind provided opening (8, 8.1, 8.2) via a separate closure element (10, 10.1, 10.2) can be closed.

Combination container system (1) according to claim 5 or 6, characterized in that a receiving chamber (9, 9.1, 9.2) of an additional container (7) associated closure element of the central closure device (6) is formed, wherein the opening to be closed (8 , 8.1, 8.2) of the individual receiving chamber (9.1, 9.2) to be closed in the closed position of the additional container to an inner peripheral region of the central closure device (6) is directed and the second connecting elements (17) on the additional container for realizing a detachable connection with the central closure device ( 6) of the first connecting elements (14) on the additional container (7) for realizing an operative connection with the closure device (6) are formed.

Combination container system (1) according to one of claims 1 to 8, characterized in that a single receiving chamber (9, 9.1, 9.2) of the additional container (7) has a further receiving opening (27) for filling the receiving chamber (9, 9.1, 9.2) with pharmaceutical products of the second kind in the closed position of the additional container (7), which is provided in the wall of the additional container (7) and provided by a smaller dimensioning than the filling and / or removal opening provided (8, 8.1, 8.2) respective receiving chamber (9, 9.1, 9.2), preferably a dimensioning, which corresponds to a male predefined maximum size of a product of the second kind and a predefined game is characterized. 10. Combination container system (1) according to one of claims 1 to 9, characterized in that the first and / or second connecting elements (11, 12, 14, 15, 16, 17) on the central closure device (6), closure element ( 10, 10.1, 10.2), main container (2) and additional container (7) are designed as connecting elements for realizing at least one of the following types of connection or a combination thereof:

non-positive connection

positive-locking connection.

Combination container system according to claim 10, characterized in that the connection between a single auxiliary container (7) and the central closure device (6) is designed as a compound selected from the group of the following compounds:

clamp connection

press connection

bayonet connection

screw

Locking connection.

Combination container system (1) according to claim 10 or 11, characterized in that the connection between the additional container (7) and the closure element (6, 10, 10.1, 10.2) is designed as a compound selected from the group of the following compounds:

clamp connection

press connection

bayonet connection

screw

Locking connection.

13. Combination container system (1) according to one of claims 10 to 12, characterized in that the closure element (10, 10.1, 10.2) is hinged to the additional container (7) via a hinge connection (23) or an articulated connection. 14. Use of a combination container system (1) according to one of claims 1 to 13 for receiving pharmaceutical products of the first and second type of human and veterinary medicine.