WO2017010525A1 - Procédé de stérilisation à la vapeur haute pression de type à écoulement par processus thermique d'eau douce, et dispositif de stérilisation de type à écoulement - Google Patents

Procédé de stérilisation à la vapeur haute pression de type à écoulement par processus thermique d'eau douce, et dispositif de stérilisation de type à écoulement Download PDF

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WO2017010525A1
WO2017010525A1 PCT/JP2016/070728 JP2016070728W WO2017010525A1 WO 2017010525 A1 WO2017010525 A1 WO 2017010525A1 JP 2016070728 W JP2016070728 W JP 2016070728W WO 2017010525 A1 WO2017010525 A1 WO 2017010525A1
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pressure
pressure vessel
steam
sterilization
temperature
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PCT/JP2016/070728
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English (en)
Japanese (ja)
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伸洋 渡辺
志成 林
宮本　徹
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株式会社前田製作所
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam

Definitions

  • the present invention is software suitable for sterilization and drying in fields such as hospitals, medicine and pharmaceuticals, and sterilization and drying of medical instruments, linens, metal instruments, mouse / rat bedding, breeding cages and breeding equipment in laboratory animal facilities.
  • the present invention relates to a flow-type high-pressure steam sterilization method and a flow-type sterilization apparatus that apply chemical characteristics of a hydrothermal process.
  • An autoclave high-pressure steam sterilizer
  • condensation in the pressure vessel is disliked. Therefore, the steam supply pipe and the condensed water in the pressure vessel are removed with a steam trap, and steam with high dryness is supplied into the pressure vessel.
  • Non-Patent Document 1 the sterilization treatment in the medical field is required to be in accordance with the guidelines shown in Non-Patent Document 1, for example, in Japan. Sterilization by an autoclave is performed based on “3. Sterilization validation and daily management in steam sterilization” starting on page 23 of the document.
  • the present inventors applied a chemical characteristic of a soft hydrothermal process (high-temperature and high-pressure water and steam below 200 ° C.) that has almost no basic research examples, and made a high-temperature resistant protein impossible with existing autoclaves. Alternatively, it has been found that inactivation of enzymes and bacterial endotoxins is possible (Patent Documents 1, 2, and 3).
  • the present inventors have proposed a sterilization drying method in which a drying step is omitted focusing on a soft hydrothermal process (PCT / JP2014 / 080255: filing date November 2014). 14th).
  • the object to be sterilized is put into a pressure vessel in various forms and sterilized.
  • sterilization is performed in a pressure vessel in a state of being wrapped with a sheet of linen or the like.
  • the condensed water generated during the treatment in the pressure vessel is difficult to be discharged to the outside, so that the object to be sterilized cannot be sufficiently dried. Therefore, a drying process for drying the sterilized material after sterilization is often required.
  • An object of the present invention is to adopt a flow-type high-pressure steam sterilization method and flow-type sterilization using a soft hydrothermal process that can shorten the drying time of an object to be sterilized by adopting a sterilization method using a soft-hydrothermal process and ensuring sterility. To provide an apparatus.
  • the circulation type high-pressure water sterilization drying method by the soft hydrothermal process of the present invention is: An air evacuation process for evacuating air from the pressure vessel containing the material to be sterilized; A temperature raising / pressurizing step for supplying water vapor to the pressure vessel and heating the pressure vessel with a heater from the outside to increase the internal temperature and the internal pressure of the pressure vessel to a predetermined temperature and pressure, A high-pressure steam sterilization step by a soft hydrothermal process in which steam is circulated through the pressure vessel in a highly saturated steam state where the steam saturation does not fall below 100%, and the object to be sterilized is sterilized; Drying the sterilized material in the pressure vessel, In the high-pressure steam sterilization step, Supplying steam at a predetermined pressure and temperature from the upstream side of the water vapor flow direction to the pressure vessel at a predetermined flow rate through a steam supply valve maintained at a predetermined opening; The opening of the exhaust valve is adjusted according to the internal pressure of the
  • Highly saturated water vapor refers to saturated water vapor with a high degree of steam saturation and water vapor at a pressure higher than the saturated water vapor pressure.
  • the soft hydrothermal process refers to a chemical reaction using highly saturated steam at 200 ° C. or lower as a reaction medium.
  • the high steam saturation means a state where the steam saturation is 100% or more, and the steam saturation is expressed by the following equation. ⁇ Vapor density (kg / m 3 ) / Saturated water vapor density (kg / m 3 ) ⁇ ⁇ 100 (%)
  • the method of the present invention provides a sterilization process with high reliability, reproducibility, and universality, which has higher sterilization performance and less variation in sterilization performance than in the case of using an existing autoclave. It was confirmed that it could be realized.
  • a soft hydrothermal process is used, and sterilization is performed while highly saturated water vapor is circulated through the pressure vessel. That is, in the high-pressure steam sterilization step, steam at a predetermined pressure and temperature is always supplied to the pressure vessel at a predetermined flow rate through a supply valve maintained at a predetermined opening degree from the supply side (upstream side). On the water vapor discharge side of the pressure vessel, the opening degree of the exhaust valve is adjusted according to the internal pressure of the pressure vessel, and control is performed so that the internal temperature and the internal pressure of the pressure vessel are respectively maintained at predetermined values. On the other hand, in the conventional autoclave, in the sterilization process, the supply and stop of supply of water vapor are switched from the upstream side according to the internal temperature of the sealed pressure vessel.
  • the proportion of the drying time of the sterilized material after sterilization in the treatment time is large. Therefore, by shortening the drying time, the high-pressure steam sterilization processing time can be shortened, and the efficiency of the sterilization processing can be achieved. In order to shorten the drying time in the high-pressure steam sterilization treatment, it is effective to reduce the amount of condensed water generated in the pressure vessel and to quickly eliminate the generated condensed water.
  • sterilization is performed using a soft hydrothermal process while circulating highly saturated water vapor in the pressure vessel.
  • highly saturated water vapor By causing highly saturated water vapor to flow through the pressure vessel, the amount of condensed water generated in the pressure vessel can be reduced, and condensed water can be quickly eliminated.
  • the drying time of the to-be-sterilized thing after sterilization can be shortened, and the work time required for a series of sterilization processes can be shortened.
  • the present inventor has also found that the drying time required for the article to be sterilized to reach a predetermined dryness can be shortened by raising the heater exothermic temperature after the high-pressure steam sterilization step than in the sterilization step. .
  • the heating step is performed by setting the heating temperature of the heater higher than the heating temperature in the sterilization step.
  • the heating temperature of the heater is increased from 135 ° C. to 145 ° C. after the high-pressure steam sterilization step is completed.
  • the present inventor investigated the generation state of condensed water in a pressure vessel under various sterilization conditions in a flow-type high-pressure steam sterilization process using a soft hydrothermal process, and based on this, the amount of condensed water generation was affected.
  • the following factors were found to give 1) Number and pulse width of vacuum pulses in the vacuum pulse air exclusion process (the amount of condensed water generated decreases as the number of pulses increases and the pulse width increases) 2)
  • the air removal process, the temperature raising / pressurization process, and the sterilization process the amount of water vapor flowing through the pressure vessel defined by the opening of the steam supply valve (the amount of condensed water generated decreases as the amount of water vapor circulation increases).
  • Boiler pressure in the sterilization process upstream steam pressure (If the boiler pressure is increased by a predetermined amount compared to the internal pressure for sterilization of the pressure vessel, the amount of condensed water generated will be less variable.) 4) Set temperature of the heater for heating the pressure vessel (the drying amount and the drying rate are improved as the heater temperature is higher).
  • one, plural, or all of the above factors 1) to 4) are adjusted to condense after the high-pressure steam sterilization step.
  • the drying time for obtaining a desired degree of drying in the drying step is shortened.
  • the amount of condensed water generated can be reduced to a predetermined value or less, and the sterilized material can be dried within a predetermined drying time.
  • at least one, a plurality, or all of these factors are changed to a large value by a predetermined amount.
  • the inside of the pressure vessel at the end of the sterilization process is adjusted.
  • the amount of condensed water generated is reduced to a predetermined amount or less.
  • the amount of condensed water generated in the pressure vessel at the end of the sterilization step is adjusted to a predetermined amount or less by adjusting the amount of water vapor flowing through the pressure vessel defined by the opening of the steam supply valve. To reduce it.
  • the upstream water vapor pressure is increased by a predetermined amount compared to the internal pressure of the pressure vessel, and the condensation in the pressure vessel at the end of the sterilization step is performed. The variation in water generation is suppressed.
  • Non-Patent Document 1 when the internal temperature of the pressure vessel is maintained at 134 ° C. and the internal pressure of the pressure vessel is maintained at 0.204 Mpa, It is desirable to set the upstream water vapor pressure to a value 0.2 MPa higher than the internal pressure.
  • the heating temperature of the heater is 1 ° C. higher than the set internal temperature so that the difference in internal temperature during the high-pressure steam sterilization process is within 1.5 ° C.
  • the set internal temperature is 134 ° C.
  • the internal temperature of the pressure vessel in the high-pressure steam sterilization step can be set to a value within the range of 120 ° C to 150 ° C.
  • the internal pressure of the pressure vessel in the high-pressure steam sterilization drying step can be set to a value within the range of 100 kPa to 376 kPa.
  • FIG. 1 is a schematic configuration / piping system diagram of a small sterilization apparatus to which the present invention is applied. It is a schematic flowchart which shows the processing operation of the small sterilization apparatus of FIG. It is a flowchart which shows a door seal subroutine (step ST3 of FIG. 2). It is a flowchart which shows a boiler subroutine (step ST4 of FIG. 2). It is a flowchart which shows a pressure vessel (can body) heater subroutine (step ST5 of FIG. 2). It is a flowchart which shows an example of a sterilization subroutine (step ST9 of FIG. 2). It is a flowchart which shows the door seal cancellation
  • FIG. 2 is a drawing-substituting photograph showing samples 1 to 6 of sterilized materials used. It is a graph which shows the pressure change of the basic pattern of the sterilization processing operation
  • FIG. 1 is a schematic configuration / piping system diagram showing a flow-type compact sterilization apparatus according to the present embodiment.
  • the small-sized sterilization apparatus 1 includes a processing unit 2 that performs high-pressure steam sterilization processing.
  • the processing unit 2 includes a pressure vessel 3 (can body) having a capacity of 80 liters that performs sterilization processing of the sterilized material W that has been charged.
  • the pressure vessel 3 is provided with a heater 4 for heating the pressure vessel 3 from the outside, a temperature detection unit 5 for detecting the internal temperature and the internal pressure of the pressure vessel 3, and a pressure detection unit 6.
  • An opening / closing mechanism 7 for the door 3a of the pressure vessel 3 is disposed.
  • a boiler unit 10 for supplying water vapor to the pressure vessel 3 is disposed upstream of the pressure vessel 3 in the direction of water vapor flow.
  • the boiler unit 10 includes a boiler 11 and a boiler water supply tank 12.
  • a vacuum pump 13 for evacuating the pressure vessel 3 and a drainage cooling unit 15 including a drainage tank 14 are disposed downstream of the pressure vessel 3 in the water vapor circulation direction.
  • the operation of the high pressure steam sterilization process of the small sterilizer 1 is controlled by the control panel 16.
  • An operation / display unit 17 is connected to the control panel 16.
  • the operation / display unit 17 includes a display screen 18 and a plurality of operation buttons 19. By operating the operation button 19, it is possible to set and input a temperature, pressure, and processing time at the time of sterilization, which will be described later (in this small sterilization apparatus, it is operated by a touch panel).
  • the display screen 18 can display the apparatus operating state including the temperature and pressure during the high-pressure steam sterilization process.
  • the temperature detector 5 that detects the internal temperature of the pressure vessel 3 heated by the heater 4 includes, for example, an upper portion, a central portion, and a lower portion at the center position in the direction of the central axis within the horizontally placed pressure vessel 3.
  • the pressure detection unit 6 that detects the internal pressure of the pressure vessel 3 includes one pressure sensor PT1 and one pressure gauge PT2.
  • the boiler 11 is connected to the pressure vessel 3 through the steam supply pipe 21.
  • the steam supply pipe 21 is provided with a steam supply electromagnetic valve 22 on the upstream side thereof, and on the downstream side thereof with a steam supply motor valve 23 maintained at a predetermined opening degree.
  • An exhaust motor valve 33 that is maintained at a predetermined opening degree according to the internal pressure detected by the pressure sensor PT1 is disposed downstream of the pressure vessel 3.
  • the boiler 11 heats the soft water supplied from the boiler feed water tank 12 to generate water vapor.
  • the generated water vapor is supplied to the pressure vessel 3 through the steam supply pipe 21.
  • the boiler 11 is connected to the drainage tank 14 via a drain pipe 24 and a boiler drain valve 25.
  • the opening / closing mechanism 7 of the door 3a attached to the inlet side of the pressure vessel 3 includes a compressor 26, a door opening electromagnetic valve 27, and a door tightening electromagnetic valve 28.
  • An air supply pipe 34 and an exhaust pipe 31 are connected to the pressure vessel 3.
  • the pressure vessel 3 is supplied with air through an air supply pipe 34 and a vacuum pump air supply valve (supply electromagnetic valve) 35.
  • the exhaust pipe 31 is connected to the suction side of the vacuum pump 13 via a vacuum motor valve 32, and is connected to the drainage tank 14 via an exhaust motor valve 33. Further, water is supplied to the vacuum pump 13 via a vacuum pump water supply valve 36.
  • FIG. 2 is a schematic flowchart showing the high-pressure steam sterilization operation of the small sterilization apparatus 1.
  • a processing operation mode a single pattern or a plurality of types of patterns can be prepared, and these operation patterns can be set in the control panel 16. For example, the operator can select one of these by operating the operation button 19 of the operation / display unit 17.
  • sterilization processing operation In the high-pressure steam sterilization processing operation (hereinafter sometimes simply referred to as “sterilization processing operation”), first, the preheating process of the pressure vessel 3 is performed, and after the preheating process, the sterilization processing operation shown in FIG. Is started. The preheating process will be described later (see FIGS. 10 and 11).
  • step ST1 an object to be sterilized is put into the pressure vessel 3, the door 3a is closed (step ST2), and the sterilization process is started (step ST2).
  • a door seal subroutine step ST3: see FIG. 3
  • a boiler subroutine step ST4: see FIG. 4
  • step ST6 see FIG. 5
  • step ST9 air exclusion process, temperature rising / pressurization process, sterilization process and drying process, see FIG. 6
  • the internal pressure of the pressure vessel 3 is returned to atmospheric pressure (step ST10), the door seal is released (step ST11: see FIG. 7), the door 3a is opened, and the sterilized material after sterilization is taken out (step ST12).
  • FIG. 3 is a flowchart showing a door seal subroutine (step ST3 in FIG. 2).
  • the door closing limit switches LS1 and LS2 see FIG. 1
  • the door tightening solenoid valve 28 is opened, and the compressor 26 is turned on. Entering (turning on), holding at the set pressure, sealing the door 3a with the specified sealing pressure (steps ST302 and 303), turning off the compressor 26 (closing), and closing the door tightening electromagnetic valve 28 (step ST304).
  • the sealed state is maintained until the end of sterilization (steps ST302 to ST305).
  • the door tightening electromagnetic valve 28 is closed, and then the open valve is opened to turn on the vacuum pump. As a result, the seal of the door 3a is released.
  • FIG. 4 is a flowchart showing the boiler subroutine (step ST4 in FIG. 2).
  • the feed water pump WP (see FIG. 1) is driven and controlled so that the water level is maintained between the low water level and the high water level (steps ST402 to 405).
  • the built-in heater is controlled so that the pressure of the generated steam is maintained at the specified pressure (steps ST406 to 409).
  • the steam controlled to the specified pressure is supplied to the pressure vessel 3 side.
  • FIG. 5 is a flowchart showing a pressure vessel (can body) heater subroutine (step ST5 in FIG. 2). During driving of the heater 4 (step ST501), on / off control of the heater 4 is performed so that the heat generation temperature is maintained at a specified temperature (steps ST502 to 505).
  • FIG. 6 is a flowchart showing an example of a sterilization subroutine (step ST9 in FIG. 2), and FIG. 8 is a time chart of the sterilization processing operation pattern.
  • steps ST1 to ST8 in FIG. 2 are preparation steps.
  • an air exclusion process of the pressure vessel 3 is performed.
  • the exhaust motor valve 33 and the air supply electromagnetic valve 35 are closed, the vacuum pump 13 is turned on, the vacuum motor valve 32 and the vacuum pump water supply valve 36 are opened (steps ST901 and 902), and the internal pressure of the pressure vessel 3 is set to a specified negative pressure. Later, the vacuum motor valve 32 is closed, the vacuum pump 13 is turned off, and the vacuum pump water supply valve 36 is closed (steps ST903 and 904).
  • step ST905 to 914 opening / closing control of the steam supply motor valve 23 and the steam supply electromagnetic valve 22 is performed, and a temperature rising / pressurizing step (pulse pressure increasing) in which two vacuum pulses are applied to the pressure vessel 3 is performed to define the internal pressure of the pressure vessel 3.
  • the sterilization pressure is increased to 0.204 MPa (steps ST905 to 914).
  • the heater 4 controls the internal temperature of the pressure vessel 3 to be a prescribed sterilization temperature of 134 ° C. (refer to the can body heater subroutine in FIG. 6).
  • the sterilization process is performed while maintaining the sterilization pressure for a predetermined time (step ST916).
  • the steam supply electromagnetic valve 22 is maintained in an open state
  • the steam supply motor valve 23 is maintained at a constant opening, for example, a large opening of 70%, and a predetermined flow rate of water vapor passes through the pressure vessel 3. Circulate.
  • the control panel 16 (see FIG. 1) adjusts the opening degree of the exhaust motor valve 33 based on the internal pressure of the pressure vessel 3, and sets the internal pressure and internal temperature of the pressure vessel 3 to values suitable for sterilization (for example, 0. 0). 204 MPa, 134 ° C.). Thereby, highly saturated water vapor
  • the steam supply motor valve 23 and the steam supply electromagnetic valve 22 are closed and the pressure vessel 3 is evacuated to bring the internal pressure of the pressure vessel 3 to a pressure state slightly higher than the atmospheric pressure.
  • the exhaust motor valve 33 is closed, the vacuum pump water supply valve 36 is opened, and the internal pressure of the pressure vessel 3 is made slightly lower than the atmospheric pressure (steps ST919 to 921).
  • the air supply electromagnetic valve 35 is opened, and the pressure vessel 3 is blown for a specified blowing time (steps ST922 and ST923).
  • the sterilized material to be sterilized in the pressure vessel 3 is dried through a drying process consisting of exhaust and ventilation.
  • the vacuum motor valve 32 is closed, the vacuum pump 13 is turned off, and the vacuum pump water supply valve 36 is closed (step ST924).
  • FIG. 7 is a flowchart showing a door seal release subroutine (step ST11 in FIG. 2) for taking out the processed sterilized material.
  • the vacuum pump 13 is turned on, the door opening solenoid valve 27 is opened, the state is maintained for a specified time to release the sealing pressure, the vacuum pump 13 is turned off, and the door opening solenoid valve 27 is closed (step) ST111-113).
  • the door 3a can be opened.
  • the door 3a is opened and the article to be sterilized is taken out.
  • FIG. 9 is a time chart showing another pattern example of the sterilization processing operation.
  • the air evacuation process in the pattern shown in FIG. 8 described above is performed by a vacuum pulse method in which evacuation and water vapor introduction are repeated as one pulse for three pulses, and a temperature rise and pressure increase process (pulse pressure increase)
  • the difference is that the number of pulses applied is only once, and the drying process is vacuum drying by evacuation, and mixed drying in which evacuation and air supply in a negative pressure state are repeated twice in a pulsed manner. Yes.
  • the sterilization process is the same.
  • FIG. 10 is a flowchart which shows an example of the preheating process of the small sterilizer 1, and FIG. 11 is the time chart.
  • the water vapor generated in the boiler 11 is supplied to the pressure vessel 3, and in parallel with this, the pressure vessel 3 is heated to bring the pressure vessel 3 in the normal temperature and normal pressure state into a predetermined specified pressure and a predetermined amount.
  • the seal pressure of the door 3a is increased to the specified seal pressure (steps ST131 to ST138 in FIG. 10).
  • the present inventors perform the sterilization process using the compact sterilization apparatus 1 having the above-described configuration under the conditions of 134 ° C., 0.204 MPa, and sterilization time of 3.5 minutes, for example, according to the guidelines shown in Non-Patent Document 1. An experiment for evaluating the drying property was conducted.
  • FIG. 12 is a drawing-substituting photograph showing samples 1 to 6 of the article to be sterilized W used.
  • These samples 1 to 6 are small steel pieces such as bolts and nuts, and each weighed 7.5 kg.
  • Each of these samples 1 to 6 was sterilized by placing 7.5 kg of two sets in a pressure vessel.
  • these samples 1 to 6 are put in the pressure vessel 3 in a state of being wrapped in a breathable sheet, or in a state of being wrapped in linen in this experiment, and condensed water generated during the treatment is not discharged from the pressure vessel 3. I did it.
  • FIG. 13 is a graph showing the pressure change of the basic pattern of the sterilization operation adopted in the experiment
  • FIG. 14 is a graph showing the temperature change
  • FIG. 15 is a graph showing the pressure and temperature change in the sterilization process. .
  • Analysis item 1 By changing the drying time in the sterilization method of the present invention, the mass increase rate, the mass increase amount, and the mass after sterilization were measured, and the required drying time was compared with the drying time in a conventional autoclave.
  • the experiment was performed when the boiler set pressure, the high-pressure steam flow rate, and the heater heat generation temperature were changed in the pulse-type drying process according to the basic pattern shown in FIG. The test was performed when the pulse width (pulse delay amount) was changed.
  • Analysis item 2 Change the boiler set pressure (upstream steam pressure) to measure the sample mass increase rate, mass increase and mass at the end of the sterilization process, and condense in the boiler set pressure and sterilization method using soft hydrothermal process The relationship with the amount of water generation was analyzed.
  • Analysis item 3 In the temperature raising and pressurization process, air exclusion process and sterilization process, the opening degree of the steam supply motor valve on the upstream side is changed to change the high-pressure steam flow rate in the pressure vessel 3, and the mass increase rate and mass increase of the sample at the end of the sterilization process The amount and mass after sterilization were measured, and the relationship between the opening degree (water vapor flow rate) and the amount of condensed water generated in the sterilization method using the soft hydrothermal process was analyzed.
  • Analysis item 4 Change the heater exotherm temperature after the sterilization process, measure the sample mass increase rate, mass increase amount and mass after sterilization, and determine the heater exotherm temperature and the amount of condensed water generated in the sterilization method using the soft hydrothermal process. The relationship was analyzed.
  • Analysis item 5 When the air evacuation process before the sterilization process is performed by the vacuum pulse method, the number of pulses and the pulse width (pulse delay amount) are changed, and the mass increase rate, mass increase amount and mass after sterilization processing after the sample sterilization process are changed. Measurements were made to analyze the relationship between the application mode of the vacuum pulse and the amount of condensed water generated in the sterilization method using the soft hydrothermal process.
  • FIG. 16 is a graph and chart showing the experimental results for Samples 5 and 6 (see FIG. 12).
  • the drying time is 40 minutes and the mass increase rate is ⁇ 0.17% or less, which is an indicator of drying property.
  • the drying time is 25 minutes, the mass increase rate is -0.17%, the pulse width (pulse delay amount) is changed, and the heater heating temperature
  • the drying time was 20 minutes and the mass increase rate was -0.21%, which was less than -0.17%. Therefore, it was confirmed that the drying time can be shortened from 40 minutes to 20 minutes as compared with the existing sterilizer.
  • FIG. 17 is a graph and a table showing the experimental results for Sample 1 (see FIG. 12).
  • the boiler set pressure changes, there is almost no difference in mass increase (condensed water generation amount), and when the pressure is 0.4 MPa, there is little variation in mass increase (SD).
  • SD mass increase
  • the pressure vessel sterilization process temperature is 134 ° C. and the internal pressure is 0.204 MPa
  • the amount of condensed water generated can be stably reduced by setting the boiler set pressure 0.2 MPa higher. Thereby, the drying time in a drying process can be shortened stably.
  • FIG. 18 is a graph and chart showing experimental results for Samples 1, 2 and 3. It can be seen that drying increases as the steam supply motor valve opening increases, and as the amount of water vapor increases. Specifically, it is preferable to increase the amount of water vapor at a predetermined temperature and pressure by setting the opening in the air removing step, the temperature raising and pressurizing step, and the sterilization step to 75% or more, so that drying increases.
  • FIG. 19 is a graph and a table showing experimental results for Sample 2.
  • the mass increase is larger on the minus side as the heater heat generation temperature is higher. In other words, drying increases as the heater heating temperature increases.
  • the heater heat generation temperature after the sterilization process is preferably increased from 135 ° C., which is the heat generation temperature in the sterilization process, to 145 ° C. .
  • FIG. 20 is a graph and a table showing experimental results when the number of pulses for sample 3 is changed. It can be seen that in the vacuum pulse type air exclusion process prior to the sterilization process, when the number of pulses of 0.03 MPa to -0.092 MPa is increased by the dynamic pulse system, drying is enhanced.
  • FIG. 21 is a graph and a table showing the experimental results when the pulse width of the air removal process for sample 3 is changed.
  • the pulse delay time (minutes) is the time between ⁇ 0.065 MPa and ⁇ 0.092 MPa in each pulse. It can be seen that the drying time increases when the pulse time is extended.
  • the number of pulses in the air exclusion process may be increased to increase the pulse time. Considering shortening of the entire process time, it is more efficient and desirable to increase the pulse width (pulse delay amount).
  • the drying time is 25 minutes and the mass increase rate is ⁇ 0.17%.
  • the drying time is 20 minutes and the mass increase rate is -0.17%. It was -0.21% below. Therefore, it was confirmed that the drying time can be shortened from 40 minutes to 20 minutes as compared with the existing sterilizer. For example, when the sterilization process temperature of the pressure vessel is 134 ° C.
  • the set temperature (exothermic temperature) of the pressure vessel heater is increased from 135 ° C. to 145 ° C. in the drying step. It was suggested that the drying time in the drying process can be shortened to within 20 minutes by increasing the number of pulses in the vacuum pulse type air exclusion process before the sterilization process or by increasing the pulse width.
  • the amount of condensed water generated can be reduced by increasing the amount of steam flow by increasing the opening of the steam supply motor valve on the upstream side of the pressure vessel, so that the drying time in the drying process can be further shortened.
  • the boiler set pressure upstream water vapor pressure
  • 0.204 MPa the internal pressure of the pressure vessel in the sterilization process. Since the amount of condensed water generated can be stably reduced by increasing the pressure by 0.2 MPa, it is possible to eliminate variations in the dried state of the sterilized material after drying.

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Abstract

Selon l'invention, dans un dispositif de stérilisation de petite taille de type à écoulement (1) mettant en œuvre un processus thermique d'eau douce, une étape de stérilisation à la vapeur haute pression au moyen d'un processus thermique d'eau douce est réalisée, dans laquelle de la vapeur est amenée à s'écouler par un récipient sous pression (3) dans un étant de vapeur hautement saturée où la saturation de la vapeur n'est pas inférieure à 100 %, afin de stériliser un objet à stériliser. Dans l'étape de stérilisation à la vapeur haute pression, la vapeur à pression et à température prédéfinies est fournie au récipient sous pression selon un débit prédéfini par l'intermédiaire d'une soupape motorisée d'alimentation en vapeur (23) maintenue à un degré d'ouverture prédéfini, et sur un côté aval du récipient sous pression (3), le degré d'ouverture d'une soupape motorisée de ventilation (33) est ajusté en fonction de la pression interne du récipient sous pression (3) pour commander la température interne et la pression interne du récipient sous pression (3) de façon à les maintenir aux valeurs prédéfinies respectives. Grâce à cette configuration, le temps de séchage de l'objet à stériliser après la stérilisation peut être réduit de manière significative.
PCT/JP2016/070728 2015-07-14 2016-07-13 Procédé de stérilisation à la vapeur haute pression de type à écoulement par processus thermique d'eau douce, et dispositif de stérilisation de type à écoulement WO2017010525A1 (fr)

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JP2019165877A (ja) * 2018-03-22 2019-10-03 サクラエスアイ株式会社 蒸気滅菌装置
US11007289B2 (en) 2019-02-14 2021-05-18 American Sterilizer Company Method for pressurizing a steam sterilization chamber
KR20210138191A (ko) * 2020-05-11 2021-11-19 (주)에스디플렉스 감압밸브 차등 압력 제어를 이용한 열에너지 절감 시스템
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CN114872326A (zh) * 2022-05-13 2022-08-09 南京航空航天大学 一种用于热塑性复合材料与轻质合金搭接结构的热压焊接设备及方法

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JP2019165877A (ja) * 2018-03-22 2019-10-03 サクラエスアイ株式会社 蒸気滅菌装置
US11007289B2 (en) 2019-02-14 2021-05-18 American Sterilizer Company Method for pressurizing a steam sterilization chamber
KR20210138191A (ko) * 2020-05-11 2021-11-19 (주)에스디플렉스 감압밸브 차등 압력 제어를 이용한 열에너지 절감 시스템
KR20210138190A (ko) * 2020-05-11 2021-11-19 (주)에스디플렉스 급기밸브를 이용한 열에너지 절감 시스템
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KR102351568B1 (ko) * 2020-05-11 2022-01-14 (주)에스디플렉스 감압밸브 차등 압력 제어를 이용한 열에너지 절감 시스템
CN114872326A (zh) * 2022-05-13 2022-08-09 南京航空航天大学 一种用于热塑性复合材料与轻质合金搭接结构的热压焊接设备及方法

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