WO2016207075A1 - Procédé de formation d'une liaison adhésive entre des premier et deuxième composants d'un dispositif et un dispositif formé par le procédé - Google Patents

Procédé de formation d'une liaison adhésive entre des premier et deuxième composants d'un dispositif et un dispositif formé par le procédé Download PDF

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Publication number
WO2016207075A1
WO2016207075A1 PCT/EP2016/064039 EP2016064039W WO2016207075A1 WO 2016207075 A1 WO2016207075 A1 WO 2016207075A1 EP 2016064039 W EP2016064039 W EP 2016064039W WO 2016207075 A1 WO2016207075 A1 WO 2016207075A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
adhesive
channel configuration
glue channel
glue
Prior art date
Application number
PCT/EP2016/064039
Other languages
English (en)
Inventor
Niels Frederik Keiser-Nielsen
Ebbe Jannes Larsen
Mads Faber MADSEN
Laurits Højgaard OLESEN
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2016207075A1 publication Critical patent/WO2016207075A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B11/00—Connecting constructional elements or machine parts by sticking or pressing them together, e.g. cold pressure welding
    • F16B11/006—Connecting constructional elements or machine parts by sticking or pressing them together, e.g. cold pressure welding by gluing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels

Definitions

  • the invention provides improvements with respect to
  • the invention provides improvements having regard to factors including durability and robustness for such devices manufactured by the method.
  • the present invention relates to a method of forming an adhesive bond between first and second components of a device, the method comprising the steps of: a) providing a first component,
  • the method according to the first aspect enables the adhesive to be distributed in a desired configuration onto the second component prior to bringing the two components into mating or immediate contact.
  • the adhesive will be positioned at locations that allow a rapid redistribution to the second glue channel, i.e. the final destination for receiving the adhesive. This enables a reduction in the process time for fastening the relevant components relative to each other in their final interrelated position.
  • the migration of the adhesive in the first channel configuration may occur while positioning the components relative to each other, e.g . while the first component and second components are moved relative to each other so as to position the two components in their final interrelated position.
  • the method according to the first aspect enables a more accurate application of the adhesive to areas of components that are intended for receiving the adhesive while minimizing the risk that adhesive may leak or may become applied outside intended areas.
  • the method according to the first aspect further provides freedom in design.
  • locations on the assembly formed by first and second components may require openings for depositing an adhesive from a source to enable the adhesive to be applied to the glue channels.
  • the deposition of adhesive from a source occurs prior to bringing the two components into mating or immediate contact.
  • the method generally does not require dedicated filling openings or inlets in the first and second components.
  • the phrase "prior to bringing the two components into mating contact” means that the two components are initially arranged with a minimum separation distance relative to each other while the adhesive is applied onto the second component, where such minimum separation distance is chosen in the order of 2 mm or more.
  • the first glue channel configuration is configured to enable distribution of the adhesive by capillary effect in the first glue channel configuration without the deposited adhesive contacting the first component.
  • the deposited adhesive will be enabled to become distributed at least partly by capillary effect while the second component is positioned spaced from the first component by a distance, such as spaced by said minimum separation distance.
  • step c) the step of allowing the deposited adhesive to distribute in the first glue channel configuration by capillary effect occurs without the adhesive contacting the first component.
  • step d) of arranging the first component and the second component relative to each other to form an assembly said arranging may comprise moving the first component, moving the second component or moving both components relative to each other from a first separated configuration towards an assembled configuration.
  • step c) of depositing adhesive in the first glue channel configuration and allowing the deposited adhesive to distribute in the first glue channel configuration by capillary effect no further additional adhesive is deposited to the first component and/or the second component.
  • step d) of arranging the first component and the second component relative to each other to form the second glue channel configuration no further additional adhesive is deposited to the first component and/or the second component.
  • additional adhesive may be supplied from an adhesive supply while the adhesive disposed in the first glue channel configuration of the second component migrates by capillary effect into and distributes into the second glue channel configuration.
  • the second glue channel configuration forms a continuous closed channel.
  • the adhesive present in the second glue channel may be arranged to form a seal where the sealing function is provided by the cured adhesive.
  • the second glue channel may be formed to extend along peripheral areas of the first and/or second component whereby the sealing function seals areas located centrally relative to the peripheral areas.
  • first glue channel configuration is shaped to encircle the first glue channel configuration.
  • distribution of adhesive may be effectively confined to the second glue channel with no adhesive being distributed radially outside the second glue channel.
  • the areas close to rim portions of the first component or the second component can be kept free from undesired portions of the adhesive thereby preventing potential visual imperfections.
  • the areas of the second glue channel configuration may comprise areas that are contiguous to areas of the first glue channel configuration. In some embodiments, the areas of the second glue channel configuration only include areas that are contiguous to areas of the first glue channel configuration.
  • the second glue channel configuration may comprise areas that extend along the first glue channel configuration.
  • Non-limiting examples include embodiments wherein the first glue channel configuration extends in parallel with the second glue channel configuration.
  • the second glue channel configuration may comprise at least one channel wherein one end emerges at the first glue channel configuration and where the at least one channel extends in a direction away from the first glue channel configuration towards a second end.
  • one or more glue deposition areas are formed in the second component adapted to receive the adhesive as provided by a source of adhesive.
  • adhesive may be disposed by means of one or more nozzles into said one or more glue deposition areas.
  • the first glue channel configuration includes narrow areas having a smaller width than the width of said one or more glue deposition areas.
  • first glue channel configuration and the second glue channel configuration each form a capillary channel and wherein either one of said capillary channels or both capillary channels extend(s) in a non-planar manner, such as along a curved surface.
  • non-limiting examples of suitable curing methods include curing occurring by room temperature, by application of heat, radiation, such as UV radiation, or any other principles known in the art.
  • pressure may be applied so as to force the first component and the second component towards each other.
  • the first and second components of the device are components of a medical device such as a drug delivery device or a drug delivery auxiliary device adapted to be mounted relative to a drug delivery device.
  • a drug delivery device is provided in the form of a syringe or an injection pen.
  • a non-limiting example includes a drug delivery device wherein the first or the second component is provided as a housing component and wherein the other of the first and the second component is provided as an element that is to be adhesively secured to said housing component.
  • Exemplary elements could include a secondary housing component, a display window, a decal, a label, an identifier, a pen clip, etc.
  • first and second components are components that are comprised within a pen needle for cooperation with a drug delivery device.
  • first and second components are components comprised within an add-on monitoring device for attachment to a drug delivery device.
  • the present invention relates to a drug delivery device for injecting a drug from a reservoir, wherein the drug delivery device comprises a first component and a second component and wherein the first component and the second component is attached relative to each other by the adhesive bonding method in accordance with the first aspect of the invention.
  • the drug delivery device comprises a first component and a second component and wherein the first component and the second component is attached relative to each other by the adhesive bonding method in accordance with the first aspect of the invention.
  • the distribution of the adhesive may be aided by other factors such as gravity, mechanical force application, magnetic force application etc.
  • the distribution of the adhesive may occur exclusively by capillary forces.
  • fig. 1 shows a side view of a pen-formed drug delivery device
  • fig. 2a shows a perspective view of first and second components of the drug delivery device intended for being mutually attached by adhering
  • fig. 2b shows a side view of the first and second components after attachment
  • fig. 2c shows a cross sectional view along section C-C shown in fig. 2b
  • fig. 3a, fig. 3b, fig . 3c and fig. 3d respectively show a front view, a rear view, a side view and a cross sectional view through section G-G of the second component
  • fig. 4 schematically shows the second component and liquid adhesive
  • FIG. 6 fig. 6, view a') through c') show liquid adhesive migration after the second component and the first component have been moved into immediate contact with each other.
  • the device represents a "generic" prior art drug delivery device providing an example of an injection pen, i.e. a pen shaped injection device for injection of one or more doses of a drug and being provided with a drug expelling mechanism.
  • a drug delivery device similar to the device of fig. 1 is marketed by Novo Nordisk A/S as NovoPen Echo®.
  • the pen device 1 comprises a cap part (not shown) and a main part having a proximal body or drive assembly portion 10 with a housing component 110 in which a drug expelling mechanism is arranged or integrated, and a distal cartridge holder portion in which a drug-filled transparent cartridge 30 with a distal needle- penetrable septum can be arranged and retained in place by a cartridge holder 20 releasably attached to the proximal portion, e.g. by a threaded connection or a bayonet coupling, the cartridge holder having openings allowing a portion of the cartridge to be inspected.
  • the cartridge may for example contain an insulin, GLP-1 or growth hormone formulation.
  • the device is designed to be loaded by the user with a new cartridge through a proximal receiving opening in the cartridge holder, the cartridge being provided with a piston driven by a piston rod forming part of the expelling mechanism.
  • a proximal-most rotatable dose member 130 serves to manually set a desired dose of drug shown in display window 120 and which can then be expelled when the button 135 is actuated.
  • the expelling mechanism may comprise a spring which is strained during dose setting and then released to drive the piston rod when the release button is actuated, this being known from e.g. the FlexTouch® offered by Novo Nordisk A/S.
  • the expelling mechanism may be fully manual in which case the dose member and the actuation button moves proximally during dose setting corresponding to the set dose size, and then is moved distally by the user to expel the set dose, this corresponding to the shown embodiment.
  • the cartridge is provided with distal coupling means in the form of a needle hub mount allowing a needle assembly 40 to be mounted, e.g. by means of a thread or a bayonet coupling.
  • the cartridge holder may alternatively be fixedly attached to the proximal body so as to form a prefilled injection pen, i.e. a disposable injection device.
  • the two components are provided as the housing component 110 and the display window 120, but any other components of a device suitable for adhesive bonding may equally well be adapted for such bonding method.
  • the housing component 110 of the device may be provided as a shell made of a material such as a steel alloy, aluminium or plastic.
  • the shell is formed as a tubular component comprising a window opening 111 located in a side wall portion of the shell, the window opening 111 defining a display area for receiving the above mentioned display window 120.
  • the component forming the display window 120 is in the shown example provided as a multi-shot injection moulded element.
  • the display window 120 defines a front surface that, when attached relative to housing component 110, points away from a central longitudinal axis of the tubular housing component 110.
  • a rear surface of the display window 120 is configured for being secured to the outer surface of housing component 110 at the periphery of the window opening 111.
  • Display window 120 includes a transparent portion 121 which enables visible inspection of a display, such as a scale drum provided with a series of dose-scale indications, arranged internally in housing component 110.
  • the transparent portion 121 is surrounded by a blinding portion 122 providing a non-transparent frame section.
  • the overall outer shape of display window exhibits upper and lower long edges adapted to extend along the axis of the housing component 110 and short edges arranged at left and right sides adapted to extend along the circumference of housing component 110.
  • An arrow element 123 is disposed mainly in the blinding portion 122 and points towards a region of the transparent portion 121.
  • the transparent portion 121 performs as a magnifying glass to increase the visibility of the dose size that is shown in display window 120.
  • Display window 120 is further shown in fig. 3b and 3c where fig. 3b shows a rear view whereas fig. 3c shows a side view.
  • Fig. 3d is a cross sectional view of display window 120 along section G-G as indicated in fig. 3b.
  • the rear surface of display window 120 generally exhibits a curved shape configured to correspond to the curvature of the outer surface of the tubular housing component 110.
  • a peripheral recessed channel 120b extends along the periphery of display window 120 but spaced relative therefrom by a small distance.
  • a first adherence section 120c extends all the way along the periphery of display window 120 and defines a band shaped region having a surface exhibiting a curvature that enables intimate contact with the housing component 110.
  • the first adherence section 120c is adapted to be attached to the housing component 110 by means of an adhesive.
  • the outer boundary of the recessed channel 120b adjoins the first adherence section 120c.
  • further band shaped regions are provided that extend along the inner boundary of recessed channel 120b. These further band shaped regions exhibits a surface having a curvature enabling intimate contact with the housing component 110 thereby defining a second adherence section 120d.
  • the inner boundary of the recessed channel 120b adjoins the second adherence section 120c.
  • a glue deposition area 120a is formed arranged to receive a liquid adhesive for example as applied by means of an adhesive dispensing nozzle.
  • Each of the glue deposition areas 120a define a widened area of the recessed channel 120b and thus functions as a buffer volume for liquid adhesive.
  • the shape of the recessed channel 120b is so formed that when the window component 120 is spaced away from housing component 110, a liquid adhesive that is present in each of the glue deposition areas 120a seeks to flow by capillary action towards the narrow parts of the recessed channel 120b.
  • the glue deposition areas 120a and the recessed channel 120b commonly define a first glue channel configuration.
  • Fig. 4 schematically shows liquid adhesive application through three different stages.
  • the display window 120 is not yet in contact with housing component 110
  • portions of a low viscosity liquid adhesive 250 is applied at each of the glue deposition areas 120a.
  • liquid adhesive may be applied by using one or more adhesive dispensing nozzles but other applicable glue deposition methods may alternatively be used.
  • View B) shows that liquid adhesive rapidly
  • View C) shows the final distribution of the adhesive 250c and 250d after the display window 120 is mated with housing component 110, i.e. in the state where they have been into close proximity or even contact.
  • the display window 120 and the housing component 110 is moved into intimate contact though leaving a minor gap between the components.
  • Surfaces of the first adherence section 120c and the second adherence section 120d together with the adjacent outer surfaces of the housing component 110 forms a second glue channel configuration. Due to the geometry of the second glue channel configuration (110, 120c, 120d) the adhesive previously present in the adhesive configuration 250b as shown in view B) will seek to be drawn into the final distribution 250c and 250d by capillary forces.
  • the three different views a) through c) schematically show liquid adhesive migration on the second component prior to assembling the second component with the first component.
  • the three views a') through c') schematically show liquid adhesive migration between the second component and the first component subsequent to assembling the second component with the first component.
  • the series of views in fig. 5 and fig. 6 depict the display window 120 and the housing component 110 in cross section along section C-C as depicted in fig. 2c.
  • Liquid adhesive 250 is only shown in the right-hand side of each view, whereas, for illustrative purposes, the left- hand side of each view has been shown omitting the liquid adhesive.
  • the display window 120 having the adhesive 250 arranged in the adhesive configuration 250b, and housing component 110 is moved relative to each other so that the two components enter into the configuration shown in fig. 6, view a').
  • the housing component 110 has been moved into contact with the adhesive present in in the recessed channel 120b.
  • no adhesive is present at the first adherence section 120c or in second adherence section 120d (120d not shown in fig. 6).
  • the relative position between housing component 110 and display window 120 is accurately controlled so that a small gap between adherence section 120c and housing component is formed allowing the adhesive 250b present in recessed channel 120b gradually seeking to flow into the gap by capillary action, cf. fig. 6, views b') and c'). Due to the capillary action, the adhesive that is drawn into the gap accurately fills the gap at the intended target areas thereby avoiding that adhesive is applied outside the intended target areas.
  • particular geometry features such as raised protrusions on the display window 120 and/or the housing component 110 may be used to accurately define the gap between the two components enabling an effective distribution of adhesive to be provided.
  • assembly machinery may serve to accurately define said gap.
  • the adhesive is cured.
  • the curing of the adhesive may occur by room temperature or by application of heat, by radiation, such as UV radiation or using any other principles known in the art.
  • the two components After curing of the adhesive the two components are effectively secured to each other leaving a strong bond between the two components.
  • the provided attachment may serve as an effective seal preventing ingress of moisture or dirt across the seal.

Abstract

L'invention concerne un procédé de formation d'une liaison adhésive entre des premier et deuxième composants d'un dispositif. Le procédé comprend les étapes consistant à a) mettre en œuvre un premier composant (110), b) mettre en œuvre un deuxième composant (120), le deuxième composant définissant une première configuration formant canal de colle (120a, 120b) servant à recevoir un adhésif (250), c) déposer de l'adhésif (250) dans la première configuration formant canal de colle (120a, 120b) du deuxième composant (120) et permettre à l'adhésif déposé (250) de se répartir dans la première configuration formant canal de colle (120a, 120b) par effet capillaire, d) agencer le premier composant (110) et le deuxième composant (120) l'un par rapport à l'autre pour former un ensemble formant ainsi une deuxième configuration formant canal de colle (110, 120c, 120d) défini par des géométries de la surface du premier composant (110) et des géométries de la surface du deuxième composant (120), e) permettre à au moins une partie de l'adhésif (250) disposé dans la première configuration formant canal de colle (120a, 120b) du deuxième composant (120) de s'écouler par effet capillaire dans la deuxième configuration formant canal de colle (110, 120c, 20d) et de se répartir dans celle-ci, et f) laisser l'adhésif (250) disposé dans la deuxième configuration formant canal de colle (110, 120c, 120d) durcir.
PCT/EP2016/064039 2015-06-26 2016-06-17 Procédé de formation d'une liaison adhésive entre des premier et deuxième composants d'un dispositif et un dispositif formé par le procédé WO2016207075A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15174115 2015-06-26
EP15174115.4 2015-06-26

Publications (1)

Publication Number Publication Date
WO2016207075A1 true WO2016207075A1 (fr) 2016-12-29

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Application Number Title Priority Date Filing Date
PCT/EP2016/064039 WO2016207075A1 (fr) 2015-06-26 2016-06-17 Procédé de formation d'une liaison adhésive entre des premier et deuxième composants d'un dispositif et un dispositif formé par le procédé

Country Status (1)

Country Link
WO (1) WO2016207075A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711650A1 (fr) 1994-11-11 1996-05-15 Rotalac Plastics Limited Collage pour solvants
EP0811667A2 (fr) * 1996-06-05 1997-12-10 Siemens Aktiengesellschaft Méthode de réalisation de liaisons de surfaces par adhésifs, d'une bonne résistance mécanique
US5837090A (en) 1994-12-08 1998-11-17 Raytheon Company Precision aligning and joining of two articles using a flowable adhesive
WO2006046164A1 (fr) 2004-10-27 2006-05-04 Koninklijke Philips Electronics N. V. Contenant pour fluides compose de deux plaques
WO2010052275A2 (fr) 2008-11-06 2010-05-14 Novo Nordisk A/S Dispositif électroniquement assisté d'administration de médicament
US20100274198A1 (en) * 2008-08-18 2010-10-28 Haselmeler Gmbh Injection device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711650A1 (fr) 1994-11-11 1996-05-15 Rotalac Plastics Limited Collage pour solvants
US5837090A (en) 1994-12-08 1998-11-17 Raytheon Company Precision aligning and joining of two articles using a flowable adhesive
EP0811667A2 (fr) * 1996-06-05 1997-12-10 Siemens Aktiengesellschaft Méthode de réalisation de liaisons de surfaces par adhésifs, d'une bonne résistance mécanique
WO2006046164A1 (fr) 2004-10-27 2006-05-04 Koninklijke Philips Electronics N. V. Contenant pour fluides compose de deux plaques
US20100274198A1 (en) * 2008-08-18 2010-10-28 Haselmeler Gmbh Injection device
WO2010052275A2 (fr) 2008-11-06 2010-05-14 Novo Nordisk A/S Dispositif électroniquement assisté d'administration de médicament

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