WO2016193630A1 - Paillette pour la conservation d'une dose prédéterminée de substance à base liquide, ainsi que dispositif d'injection et procédé la mettant en oeuvre - Google Patents
Paillette pour la conservation d'une dose prédéterminée de substance à base liquide, ainsi que dispositif d'injection et procédé la mettant en oeuvre Download PDFInfo
- Publication number
- WO2016193630A1 WO2016193630A1 PCT/FR2016/051321 FR2016051321W WO2016193630A1 WO 2016193630 A1 WO2016193630 A1 WO 2016193630A1 FR 2016051321 W FR2016051321 W FR 2016051321W WO 2016193630 A1 WO2016193630 A1 WO 2016193630A1
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- WO
- WIPO (PCT)
- Prior art keywords
- tube
- plug
- straw
- liquid
- based substance
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
- A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing
- A61D19/024—Tube-like containers, e.g. straws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
- A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
Definitions
- Paillette for preserving a predetermined dose of liquid-based substance, as well as an injection device and method for its implementation
- the invention relates generally to the preservation of a predetermined dose of liquid-based substance, and more particularly to flakes for effecting such preservation.
- Such straw comprises a tube and a plug disposed in the tube.
- the plug is usually of the tripartite type originally described in French Patent 995,878, corresponding to British Patent 669,265, that is to say formed by two buffers of fibrous substance enclosing a powder that is converted on contact with a liquid in the form of an impermeable paste or gel adhering to the wall of the tube so that the cap is liquid-tight.
- plugs of another type for example a plug comprising or associated with an insert described by the French patent application 2,771,284 corresponding to the US patent 6,300,125, by the French patent application 2,771,285 corresponding to the application.
- US Patent 2001/0014376 by the French patent application 2,784,572 corresponding to US Patent 6,416,61 1 and the French patent application 2,932,064; or a plug made of a monoblock cylinder of hydrophobic microporous material described by the European patent application 0 873 726; or finally a plug made of a monoblock cylinder of self-sealing sintered microporous material described by PCT application WO 2010/070533.
- the stopper In the initial state, the stopper is disposed in the vicinity of one of the ends of the tube and it is expected that in the filled state, the dose of liquid substance that must be stored in the straw is disposed between the stopper and the other end of the tube (end farthest from the plug).
- the end closest to the plug is placed in communication with a source of vacuum while the end farthest from the plug is placed in communication with a container containing the substance to be introduced into the straw.
- the air initially contained between the plug and the end of the tube furthest from the plug is sucked through the plug as the substance progresses in the tube until it meets the plug.
- the straw is welded in the vicinity of one or both ends and is stored cold.
- the straw and in particular the material of the tube are provided so that cold storage can be performed by immersing the straw in a liquid cryogenic agent such as liquid nitrogen.
- the invention aims to provide such a straw that offers operators new capabilities while remaining simple, convenient and economical to manufacture and use.
- the invention proposes for this purpose a straw for the preservation of a predetermined dose of liquid-based substance, comprising a tube extending between a first end and a second end and comprising a liquid-tight plug disposed in the tube in the vicinity. its first end and extending between a first end facing the first end of the tube and a second end facing the second end of the tube, characterized in that said plug:
- a male connector end extending between a first end facing the first end of the tube and a second end facing the second end of the tube, having a normalized frustoconical outer surface increasing in diameter from the first end of the tip towards the first end of the tube; the second end of the tip, configured so that a syringe needle having a standard frustoconical inner surface female connector tip can be connected to said plug by engaging the needle socket on the tip of the tip; male plug connection with the internal frustoconical surface of the socket in contact with the outer frustoconical surface of the spigot end; and
- the inner conduit of the syringe needle can thus be placed in communication, via the internal conduit of the stopper, with the space inside the tube located between the second end of the stopper and the second end of the tube.
- This internal space in the tube is intended, as in conventional flakes, to receive the predetermined dose of liquid-based substance.
- a syringe needle for example an injection needle
- the dose of substance contained in the straw is drawn towards the stopper, for example as explained below. afterwards, the substance will pass through the internal duct of the stopper and then the internal duct of the needle and may be expelled at the distal end of the needle, that is to say the pointed end located on the opposite side to the needle. the female end of the needle.
- the stopper is not moved to push the dose of substance towards the second end of the tube but that the stopper is fixed and that it is the dose of substance that is pushed towards the stopper and therefore towards the first end of the tube.
- the straw according to the invention can thus play not only the role of a substance conditioning element of the substance for its preservation, including cryogenic temperatures (traditional role for a straw), but also the role of a body of syringe to which a syringe needle can be directly connected and whose contents can be ejected through the distal end of this needle.
- the straw according to the invention makes it possible to prevent the dose of substance must be transferred from the conditioning unit that it constitutes to a syringe body.
- the handling of the liquid-based substance is diminished, which is in some cases favorable to the preservation of its properties, in particular if the substance contains constituents sensitive to the mechanical stresses occurring during the passage in a narrow conduit such as the inner duct of an injection needle.
- a substance is for example a vaccine comprising cells sensitive to mechanical stresses.
- the flake according to the invention makes it possible to benefit from the conditioning qualities of the liquid-based substances offered by the flakes, from the compatibility with the existing cold-keeping devices of the flakes, including at cryogenic temperatures, for example the conventional cups for maintaining the flakes.
- glitter in liquid nitrogen while providing the capabilities of a syringe body; and this simply by implementing in a thin tube of flake a cap configured accordingly.
- the first end of the plug in an initial state before use, is located in the tube at a predetermined distance from the first end of the tube for welding the tube between the first end of the plug and the first end of the tube.
- the tip and more generally the plug is isolated from the liquid cryogen by the tube of the straw and thus protected from any cross-contamination likely to be conveyed by the liquid cryogen.
- the straw according to the invention would have a larger capacity but could not offer such an insulation capacity of the nozzle .
- the plug in an initial state before use, has at its first end a cap to be removed closing said internal conduit of the cap.
- This seal is of course to be removed before emptying the straw.
- the presence of the lid to the flask emptying operation ensures that there is no substance that passes into cap before emptying.
- annular wall is disposed between the cap and the male end, the inner conduit of the cap extending beyond the first end of the male end in the annular wall to the operculum which the closure, the outer surface of the annular wall being recessed vis-à-vis the outer surface of the male end.
- the lid is removed by cutting or even tearing the annular wall.
- the remaining annular wall piece does not interfere with the engagement of the socket as the outer surface of the annular wall is recessed from the outer surface of the socket.
- the cap comprises a body attached to the tube and an appendage protruding from said body attached to the tube only through the body, which appendix comprises said male end and extends to the first end of the plug.
- the plug can be effectively secured to the tube by the body while the tube leaves free the outer surface of the tip.
- the tube can be removed around the appendix after being cut.
- the cap body and the tube are secured independently of a plug contact with said liquid-based substance.
- the degree of securing between the tube and the plug is the same without prior contact and after contact of the plug with the liquid-based substance.
- the body is rigid at least peripherally and has an outer surface with non-return projections oriented to allow the forced sliding of the cap vis-à-vis the tube from the first end to the second end and to resist the sliding of the cap vis-à-vis the tube to the first end of the tube;
- the body is rigid at least peripherally and has an outer surface having at least one annular rib having a straight surface facing the first end of the tube and an inclined surface turned towards the second end of the tube, the inclined surface being inclined inwards and towards the second end of the tube;
- the body is rigid at least peripherally and has an outer surface having at least two annular ribs away from one another;
- the body has on its outer surface an annular groove near the appendix;
- said male connection piece is a male luer tip
- said stopper is made entirely of material impermeable to gases and liquids independently of a contact of the stopper with said liquid-based substance;
- said stopper is made entirely of rigid plastic material molded in one piece.
- the invention also aims, in a second aspect, a device for injecting a liquid-based substance comprising a straw as explained above and a syringe needle having a female connection endpiece with frustoconical inner surface engaged on the male connection end cap of said straw.
- the invention also aims, in a third aspect, a method of emptying a straw as explained above, comprising a dose of liquid-based substance disposed between the second end of the plug and the second end of the tube, comprising the step of pushing the dose of liquid-based substance towards the first end of the tube after connecting the tip of a syringe needle to the male end of the plug.
- the step of pushing the dose of liquid-based substance is carried out with the second end of the tube remaining closed while the tube is crushed progressively from the second end of the tube towards the stopper;
- FIG. 1 is a schematic view of a straw according to the invention, in the initial state before use where it is empty and open at both ends;
- FIGS. 2 and 3 are respectively a side view and a sectional view of the plug of this straw, shown separately;
- FIG. 4 is a sectional view of the end of the straw that is seen on the left in Figure 1 except that a syringe needle has been connected to the cap of this straw after the The lid of its cap was cut and removed and its tube was cut at the same location and the cut end portion of the tube removed;
- Figure 5 is a view similar to Figure 1 but with the straw in the filled state;
- Figure 6 is a view similar to Figure 5 but with the tube of the straw welded at both ends;
- Figure 7 is a view similar to Figure 6 but after the cap of the straw cap was cut and removed and that its tube was cut at the same location and the cut end portion of the tube removed;
- FIG. 8 is a view similar to FIG. 7 except that a syringe needle has been connected to the stopper of the straw;
- FIG. 9 is a view similar to FIG. 8 but in elevation rather than in plan and further showing the rollers of a flail emptying device by progressive crushing of the tube along the latter from the end of the tube furthest from the plug;
- FIG. 10 is a view similar to FIG. 7 but with the other side of the tube which has also been cut and the end portion thus cut off which has been removed while a syringe needle has been connected to the stopper. the straw;
- - Figure 1 1 is a view similar to Figure 10 but further showing the piston of a flask emptying device by sliding the piston in the tube from the end farthest from the plug;
- FIG. 12 shows a pair of curved blade scissors for cutting the tube of the straw at the body of the plug
- FIG. 13 is a view similar to Figure 7 but with the cut tube at the body of the cap;
- Figures 14 to 16 are views similar to Figures 1 to 3, but for a variant of the straw of smaller capacity;
- Figure 17 is a view similar to Figure 8 but for this variant of the straw while the tube is cut at the body of the cap;
- Figures 18 and 19 are views similar to Figure 15 but for variants of the plug where the body is shaped differently.
- the straw 10 illustrated in Figure 1 in the initial state (before use) comprises a tube 1 1 and a plug 12.
- the tube 1 1 is extruded plastic with an internal diameter which is calibrated.
- this internal diameter is of the order of 8.20 mm and the length of the tube 1 1 is of the order of 130 mm.
- the tube 1 1 extends between one end 16 (which is seen on the left in Figure 1) and one end 17 (which is seen on the right in Figure 1).
- the material of the tube 1 1 is here Surlyn ® , which has good weldability properties and excellent compatibility with cryogenic temperatures.
- Surlyn ® which has good weldability properties and excellent compatibility with cryogenic temperatures.
- the tube material is in another heat-shrinkable plastic material and resistant to cryogenic temperatures, for example PVC, TPE or PP.
- the plug 12 is made of a material which has the same properties of impermeability to gases and liquids without and with prior contact of the plug with a liquid, especially aqueous.
- the stopper 12 does not include a powdered dry sealant that turns into a paste or gel once moistened.
- the material of the plug 12 is here polyethylene, more specifically HDPE.
- the plug 12 is in another relatively rigid thermoplastic material, for example polypropylene (PP).
- the plug 12 is disposed in the tube 1 1 near its end 16.
- the plug 12 extends between an end 19 facing the end 16 of the tube 1 1 and an end 18 facing the end 17 of the tube 1 1.
- This distance has been predetermined so that it is large enough for it to be possible to weld the tube 1 1 in the vicinity of the end 16, as shown in FIG. 6.
- the plug 12 has an axisymmetric configuration and is arranged coaxially with the tube January 1.
- the plug 12 comprises a body 9 and an appendix 63 projecting from the body 9 and extending to the end 19.
- Appendix 63 comprises a male endpiece 29, a cap 33 located at the end 19 and an annular wall 64 connecting the cap 33 and the male endpiece 29.
- the body 9 is directly attached to the tube 1 1.
- the projection 63 projecting from the body 9 is subjected to the tube 1 1 only through the body 9.
- the tube 1 1 leaves free the external surface of the appendix 63, in particular the outer surface 14 of the male endpiece 29.
- the outer surface 14 is frustoconical normalized to cooperate with the normalized frustoconical inner surface 46 of the socket 45 of a syringe needle 44 (FIG. 4).
- the portion of the tube January 1 surrounding the appendix 63 can be cut and removed, as shown in Figure 13.
- the dose of liquid-based substance 21 that must be stored in the flake 10 is placed between the stopper 12 and the end 17 of the tube 1 1 farthest from the stopper. 12.
- the straw 10 here has a useful capacity of about 4 ml.
- the tube 1 1 of the straw is welded in the vicinity of one or both ends 16 and 17 ( Figure 6) and is stored cold.
- the tube 1 1 has been welded at one end and the welded portion has subsequently been cut and removed, the tube 1 1 then has a new end set back from the initial end. Similarly, if the tube 1 1 has been cut to remove an end portion initially located around the appendix 63, the tube 1 1 then has a new end recessed relative to the initial end.
- the reference numerals 16 and 17 for the new ends of the tube 1 1 each recessed relative to the respective initial end.
- the plug 12 is placed in the tube 1 1 by simple insertion through the first end 16 of the tube 1 1 and forced sliding to the second end 17 of the tube 1 1 to reach the intended location for the plug 12 in the tube 1 1.
- the fact that the plug 12 can slide in the tube January 1 if a large force is exerted provides a holding in place of the plug 12 in the tube 1 1 sufficient to take the forces exerted during connecting a syringe needle 44 (FIG. 4) by engaging the female connection tip 45 of the needle 44 on the male connection piece 29 of the plug 12 with the surface internal frustoconical 46 of the female end 45 in contact with the outer frustoconical surface 14 of the male end 29.
- the plug 12 is configured to resist sliding towards the first end 16 of the tube January 1. This allows the plug 12 to take up the major forces exerted on the end 18 of the plug 12 by the substance 21 during the emptying (FIGS. 9 and 11) and, where appropriate, during the freezing when an increase in volume occurs. the substance 21 which urges cap 12 towards the end 16 of the tube 11.
- the male end 29 extends between an end 60 facing the end 16 of the tube January 1 and an end 61 facing the end 17 of the tube January 1.
- the frustoconical external surface 14 of the spigot 29 increases in diameter from the end 60 of the spigot 29 towards the end 61 of the spigot 29.
- the conicity of the outer surface 14 of the male end 29 is Luer dimensions, defined by the ISO 594-1: 1986 or by DIN and EN 1707: 1996 and 20594-1: 1993.
- An internal conduit 20 is formed in the plug 12.
- the inner conduit 20 extends between the end 60 of the male endpiece 29 and the end 18 of the plug 12.
- the inner conduit 20 thus passes through the male end 29 and the body 9 opening into the internal space to the tube 1 1 intended to be filled by the substance 21.
- the inner conduit 20 extends beyond the end 60 of the spigot 29 in the annular wall 64 to the seal 33 which closes it.
- the cover 33 is here formed by a straight wall oriented transversely to the inner conduit 20.
- the cover 33 is to be removed before connecting the needle 44 and empty the straw.
- the inner conduit 20 decreases in diameter from the end 18 of the plug 12 to the end 60 of the spigot 29, with three successive frustoconical portions stepped.
- the outer surface of the annular wall 64 is recessed vis-à-vis the outer surface 14 of the spigot 29.
- the lid 33 is removed by cutting or even tearing the annular wall 64.
- the remaining annular wall piece 64 does not interfere with the engagement of the socket 45 since the outer surface of the annular wall 64 is set back from the outer surface 14 of the socket 29 (see FIG. 4). .
- the thickness of the annular wall 64 is smaller than that of the spigot 29, which facilitates the cutting of the annular wall 64 to remove the lid 33.
- the body 9 extends between an end protruding from the appendix 63 (end facing the end 16 of the tube 1 1) and the end 18 of the plug 12.
- the body 9 comprises a plurality of annular ribs 22, here two identical ribs, formed on its outer surface 28.
- the ribs 22 are arranged at a distance from each other, with a predetermined distance between them. This difference makes it possible to stabilize the plug 12 in the tube 1 1.
- Each annular rib 22 has a straight surface 24 facing the end 16 of the tube 1 1 and an inclined surface 25 facing the end 17 of the tube January 1.
- the surface 25 is inclined towards the inside and toward the end 17 of the tube 11.
- annular ribs 22, thus shaped provide a non-return effect allowing the cap 12 to slide forcibly towards the tube 1 1 from the end 16 towards the end 17 and resistant to sliding of the plug 12 screw-to -vis the tube 1 1 to the end 16 of the tube 1 1.
- the material in which the plug 12 is made is relatively rigid and therefore the periphery of the body 9 is relatively rigid, and in any case more than the wall of the tube 11 which is relatively thin.
- the general diameter of the external surface 28 of the body 9 corresponds to the internal diameter of the tube 1 1.
- the inclined surfaces 25 form ramps for deforming the wall of the tube 1 1 to allow the forced sliding of the plug 12 towards the end 17 of the tube January 1.
- the straight surfaces 24 form stops to allow the plug 12 to resist sliding relative to the tube January 1.
- the body 9 also has, at the end 18 of the plug 12, a chamfered edge forming a guide surface 23 inclined towards the inside and towards the end 18 of the plug 12.
- the annular groove 30 is formed on the outer surface 28 near the appendix 63.
- annular groove 30 is formed between the appendix 63 and the annular rib 22 closest.
- the annular groove 30 has a concave curved bottom surface.
- the annular groove 30 is useful for guiding the cutting of the tube 11, for example with the pair of curved blade scissors 53 illustrated in FIG.
- the female end piece 45 extends between an end 55 that is seen on the left in FIG. 4 and an end 56 that is seen to the right.
- the female endpiece 45 has a collar 48 at its end 56.
- the needle 44 further comprises a hollow rod 39 projecting from the female endpiece 45 from its first end 55.
- the inner channel 40 of the needle 44 extends from the end 56 of the socket 45 to the tip of the hollow rod 39.
- the hollow rod 39 here has a diameter known as gauge 18 or gauge 20.
- the needle 44 is of the hypodermic type.
- the frustoconical inner surface 46 of the female endpiece 45 is in contact and matches the frustoconical outer surface 14 of the male endpiece 29.
- the inner conduit 20 of the male end 29 opens into the internal channel 40 of the needle 44.
- the straw 10 to which is connected the needle 44 with its female connection end 45 with frustoconical inner surface 46 engaged on the male connection end 29 of the plug 12 forms a device for injecting a fluid substance whose operation is explained later.
- the straw 10 illustrated in FIG. 5 comprises a predetermined dose of liquid-based substance 21, here a concentrated vaccine solution.
- the filling of the straw 10 is carried out using a needle (not shown), connected to a tank (not shown) of substance 21, which is inserted into the tube 1 1 by the end 17 of the tube 1 1 until its end comes close to the plug 12.
- the needle is gradually retracted.
- the inner conduit 20 therefore contains a certain volume of air. Note also that the volume of the predetermined dose injected is such that there remains a portion of the tube 1 1 not filled by the substance 21 on the side of the end 17.
- the tube January 1 is then welded near its two ends 16 and 17.
- a weld 41 is made using two heating jaws (not shown) between which is crushed by pinching an end portion of the tube January 1.
- the portion thus crushed takes a flattened position forming two lips 42 ( Figure 9) brought into contact with one another.
- the heat transmitted by the heating jaws to the material of the tube 1 1 causes the formation of the hermetic seal 41 between the two lips 42.
- This air bubble 43 is useful during the freezing of the straw to allow the volume increase of the substance 21.
- the tube 11 is first cut between its end 16 and the body 9 of the plug 12 and then the end portion of the tube 11 which has been cut is removed.
- the annular wall 64 of the appendix 63 is then cut and the cover 33 removed.
- the needle 44 having the female end piece 45 is then connected to the straw.
- the hollow stem 39 of the needle 44 is then, for example, sunk into the septum of a container containing a diluting liquid (e.g., water for injection) for concentrated vaccine solution (not shown).
- a diluting liquid e.g., water for injection
- a dump device (partially illustrated) is used, comprising two rollers 47 each oriented in the same direction and arranged next to each other.
- the emptying device is configured so that the rollers 47 gradually crush the tube January 1 from its end 17 to the plug 12.
- the air bubble 43 is thus pushed in the same direction and in turn pushes the substance 21 which successively introduced into the inner conduit 20 of the plug 12 and into the channel 40 of the needle 44 to be expelled from the needle 44, into the container containing the dilution liquid.
- the volume of the air bubble 43 is sufficient to fill the inner conduit 20 and the channel 40 at the moment when the rollers 47 are close to the plug 12. Thus, there is no or very little substance 21 lost in the conduit 20 and in the channel 40.
- the emptying device comprising the rollers 47 is for example implemented by further providing a body and a rail mounted fixed on the body.
- the rollers 47 are slidably mounted along the rail, with the rollers 47 each oriented transversely to the direction of extension of the rail.
- the emptying device is configured to move the rollers 47 closer or closer to one another depending on where the two rollers 47 are on the rail.
- the emptying device further comprises a resilient erasable floor disposed under the rail.
- rollers 47 are initially positioned at a first end of the rail, access to the floor being thus cleared to allow the straw 10 to be disposed therein.
- the straw is then disposed on the floor, being oriented in the same direction as the rail and located substantially between the paths respective of the two rollers 47, with the weld 41 of the straw facing the rollers 47.
- the needle 44 located at the other end of the straw is engaged in a conical housing formed in the body of the device, with the outer surface of the female end abutting against the inner surface of the conical housing.
- rollers 47 are then moved in the direction of the straw 10 and are positioned on either side of the weld 41 located near the end 17 of the straw.
- the rollers are then spaced from each other, separated by a distance slightly greater than the thickness of the weld 41 located between them.
- the rollers 47 continue their course by approaching each other until crushing the tube 1 1 of the straw 10. The gap between the rollers is then substantially equal to twice the thickness of the wall of the tube 1 1.
- rollers 47 then gradually crush the tube January 1 as explained above.
- roller 47 closest to the floor presses against an inclined surface of the floor, which urges the floor to its erased position.
- the straw 10 is then no longer held by the floor but remains in the same position because it is held by the rollers 47.
- the distal end of the floor is then positioned behind the lower roller 47 and acts as a non-return stop for the two rollers 47.
- connection of the needle 44 to the straw 10 is carried out as explained above.
- the weld 41 situated in the vicinity of the end 17 is removed by cutting an end portion flush with this weld 41.
- a device (partially illustrated) having a piston 52 is employed here.
- the piston 52 is moved to push the air bubble 43 which then pushes the substance 21 to its expulsion from the needle 44, in the same manner as in the embodiment illustrated in FIGS. 8 and 9.
- the internal diameter of the tube 1 1 1 is here of the order of 6 mm and the length of the tube 1 1 1 is of the order of 130 mm.
- the straw 1 10 here has a useful capacity of about 2 ml.
- the male end 129 is identical to the male end 29.
- the body 109 of the plug 1 12 is identical to the body 9 of the plug 12, except it is smaller in size to be able to cooperate with the tube 1 1 1 whose dimensions are smaller than those of the tube 1 1 .
- the inner conduit 120 of the plug 1 12 is here completely frustoconical.
- the use of the straw 1 10 is identical to the use of the straw 10, except that, as the tube 1 1 1 is very close to the nozzle 129, the tube 1 1 1 is cut at the level of the groove 130 to prevent the tube 1 1 1 hinders the engagement of the nozzle 145 on the nozzle 129 ( Figure 17).
- the stopper 212 illustrated in FIG. 18 is generally similar to the plug 1 12, except that the body 209 has a single annular rib 222 and this single annular rib 222 has a different profile than the ribs. 122 or 22.
- the outermost portion of the ribs 22 or 122 is formed by a stop 65 or 165
- the outermost portion of the rib 222 is formed by a circular section surface of constant diameter 66.
- the diameter of the surface 66 corresponds to that of the inner surface of the tube of the straw.
- the rib 222 On either side of the surface 66, the rib 222 has an inclined surface, respectively 67 and 68.
- the surface 67 is turned towards the first end 219 of the cap 212 and is inclined towards the first end 219 and inwards.
- the inclined surface 68 is facing the second end 218 and is inclined towards the first end 218 and inwardly.
- the plug 312 shown in Fig. 19 is generally similar to the plug 12, except that the two annular ribs 122 are replaced by a single rib 322 having a large axial extension.
- the body of the straw cap has different non-return protrusions ribs 22, 122 or 322, but arranged differently from a rib, for example in the form of a plurality of tabs.
- the plug 12, 12, 212 or 312 is not entirely disposed within the tube of the straw at a predetermined distance from its first end, but protrudes outwardly beyond its first end;
- the cap is made fixed relative to the tube other than by mechanical cooperation of surfaces, for example by providing a securing by gluing or welding;
- the tube of the straw is made of several plastics, for example by coextrusion;
- the plug 12 is made of several materials, for example a relatively flexible material for the appendage and a central portion of the body while the periphery of the body is relatively rigid material;
- the cap comprises a gas-permeable and liquid-impermeable part, to allow conventional filling, for example the cap is replaced by a tubular part associated with a gas-permeable and liquid-impervious element such as a conventional tripartite stopper;
- the appendix is permeable, for example it does not comprise a lid;
- the cap body has more than two annular ribs, for example three or four ribs;
- the contact elements of the device for emptying the tube of the straw are different from the rollers such as 47, for example two support fingers or an assembly formed by a fixed base and a movable support finger.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201680031973.9A CN107708608B (zh) | 2015-06-03 | 2016-06-02 | 预定剂量液基物质保存细管及使用细管的注射装置和方法 |
US15/578,804 US10987206B2 (en) | 2015-06-03 | 2016-06-02 | Straw for the preservation of a predetermined dose of liquid-based substance, as well as a method and injection device that employ it |
EP16738477.5A EP3302351B1 (fr) | 2015-06-03 | 2016-06-02 | Paillette pour la conservation d'une dose prédéterminée de substance à base liquide, ainsi que dispositif d'injection et procédé la mettant en oeuvre |
BR112017025219A BR112017025219A2 (pt) | 2015-06-03 | 2016-06-02 | canudo para conservar uma dose pré-determinada de substância de base líquida, e dispositivo de injeção e método implantando o mesmo |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1555026A FR3036954B1 (fr) | 2015-06-03 | 2015-06-03 | Paillette pour la conservation d'une dose predeterminee de substance a base liquide, ainsi que dispositif d'injection et procede la mettant en oeuvre |
FR1555026 | 2015-06-03 |
Publications (1)
Publication Number | Publication Date |
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WO2016193630A1 true WO2016193630A1 (fr) | 2016-12-08 |
Family
ID=54007861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2016/051321 WO2016193630A1 (fr) | 2015-06-03 | 2016-06-02 | Paillette pour la conservation d'une dose prédéterminée de substance à base liquide, ainsi que dispositif d'injection et procédé la mettant en oeuvre |
Country Status (6)
Country | Link |
---|---|
US (1) | US10987206B2 (fr) |
EP (1) | EP3302351B1 (fr) |
CN (1) | CN107708608B (fr) |
BR (1) | BR112017025219A2 (fr) |
FR (1) | FR3036954B1 (fr) |
WO (1) | WO2016193630A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3074419A1 (fr) * | 2017-12-05 | 2019-06-07 | Imv Technologies | Paillette pour la conservation cryogenique d'une dose de substance a base liquide, ensemble la comportant et procede de vidage de cette paillette |
CN111683527A (zh) * | 2017-12-14 | 2020-09-18 | 国家血液服务机构 | 即用型耐低温注射装置 |
US11116206B2 (en) | 2018-10-01 | 2021-09-14 | Cook Medical Technologies Llc | Cryocontainer |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3074419A1 (fr) * | 2017-12-05 | 2019-06-07 | Imv Technologies | Paillette pour la conservation cryogenique d'une dose de substance a base liquide, ensemble la comportant et procede de vidage de cette paillette |
WO2019110927A1 (fr) | 2017-12-05 | 2019-06-13 | Imv Technologies | Paillette pour la conservation cryogénique d'une dose de substance à base liquide, ensemble la comportant et procédé de vidage de cette paillette |
US11564389B2 (en) | 2017-12-05 | 2023-01-31 | Imv Technologies | Straw for cryogenic preservation of a dose of liquid-based substance, assembly comprising same, and method for empty this straw |
CN111683527A (zh) * | 2017-12-14 | 2020-09-18 | 国家血液服务机构 | 即用型耐低温注射装置 |
US11116206B2 (en) | 2018-10-01 | 2021-09-14 | Cook Medical Technologies Llc | Cryocontainer |
Also Published As
Publication number | Publication date |
---|---|
CN107708608A (zh) | 2018-02-16 |
EP3302351A1 (fr) | 2018-04-11 |
EP3302351B1 (fr) | 2019-03-20 |
BR112017025219A2 (pt) | 2018-08-07 |
FR3036954B1 (fr) | 2017-07-14 |
US20180110604A1 (en) | 2018-04-26 |
FR3036954A1 (fr) | 2016-12-09 |
US10987206B2 (en) | 2021-04-27 |
CN107708608B (zh) | 2019-08-13 |
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