WO2016187835A1 - Continuous blood pressure measurement method, apparatus and device - Google Patents

Continuous blood pressure measurement method, apparatus and device Download PDF

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Publication number
WO2016187835A1
WO2016187835A1 PCT/CN2015/079914 CN2015079914W WO2016187835A1 WO 2016187835 A1 WO2016187835 A1 WO 2016187835A1 CN 2015079914 W CN2015079914 W CN 2015079914W WO 2016187835 A1 WO2016187835 A1 WO 2016187835A1
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blood pressure
signal
according
volume change
pulse signal
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PCT/CN2015/079914
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French (fr)
Chinese (zh)
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汝剑飞
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华为技术有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels

Abstract

A continuous blood pressure measurement method, apparatus and device. The method comprises: an acquisition device acquiring an electrocardiosignal and an optical volume change tracing pulse signal; determining an actually measured blood pressure according to the electrocardiosignal and the optical volume change tracing pulse signal; and according to the actually measured blood pressure and a prediction equation for determining a predicted blood pressure, correcting the coefficient of the prediction equation, and calculating a blood pressure value according to the corrected prediction equation. The continuous blood pressure measurement method, apparatus and device can improve the accuracy of continuous blood pressure measurement.

Description

Continuous blood pressure measuring method, device and device Technical field

Embodiments of the present invention relate to medical device technology, and in particular, to a continuous blood pressure measurement method, apparatus, and device.

Background technique

Human blood pressure is a very important reference indicator for human health, especially cardiovascular and cerebrovascular diseases. It is also an important basis for medical workers to diagnose diseases. Therefore, users often measure and control their blood pressure, which is for health care and disease prevention. Important means.

In the prior art, there are many ways to measure blood pressure, and the use of a sphygmomanometer based on pulse wave transmission speed to measure blood pressure is a method that has been used in recent years, and the method is used by being placed at a fingertip or Electrocardiographic sensors (Electro Cardio Graphy; ECG) and Photosensors (Photo Plethysmor Graphy; PPG) collect other ECG signals and photoplethysmographic pulse signals, and according to the arterial blood pressure and pulse wave transmission speed The relationship between the blood pressure is determined. When the blood pressure rises, the blood vessels expand and the pulse wave transmission speed increases. Conversely, the pulse wave transmission speed decreases.

However, when measuring blood pressure based on the pulse wave transmission speed, it is necessary to measure with both the ECG sensor and the photoelectric sensor, and continuous blood pressure detection is not suitable. Techniques for estimating blood pressure using PPG alone have also been studied, but noise due to body noise, external disturbance light, or sweat may cause interference in PPG photoelectric detection, resulting in measurement errors, and if continuous blood pressure measurement is performed, The error will accumulate and the accuracy of continuous blood pressure measurement will not be high.

Summary of the invention

Embodiments of the present invention provide a continuous blood pressure measuring method, apparatus, and apparatus to improve the accuracy of continuous blood pressure measurement.

Embodiments of the present invention provide a continuous blood pressure measurement method, including:

Acquiring the device to obtain an ECG signal and a light volume change trace pulse signal;

The acquiring device determines the actual pulse signal according to the ECG signal and the light volume change Blood pressure;

The acquiring device determines a prediction equation for predicting blood pressure according to the measured blood pressure, corrects coefficients of the prediction equation, and calculates a blood pressure value according to the corrected prediction equation.

With reference to the first aspect, in a first possible implementation manner of the first aspect, the acquiring, by the acquiring device, the ECG signal includes:

The acquiring device collects an ECG wave through an ECG sensor;

Performing fast Fourier transform FFT processing on the ECG to obtain a processing signal;

The acquiring device performs noise removal processing on the processed signal to obtain the ECG signal.

With reference to the first aspect, or the first possible implementation manner of the first aspect, in the second possible implementation manner of the first aspect, the acquiring, by the acquiring device, the optical volume change tracing pulse signal comprises:

The acquiring device collects a pulse wave through a pulse sensor;

Performing fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;

The acquiring device performs noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.

With reference to the first aspect, the first aspect of the first aspect to the second possible implementation manner of the first aspect, in a third possible implementation manner of the first aspect, the acquiring device is according to the The electrical signal and the light volume change trace pulse signal determine the measured blood pressure value, including:

The acquiring device synchronizes the electrocardiographic signal and the optical volume change trace pulse signal to obtain a synchronization signal;

The acquiring device calculates a pulse transmission time PTT according to the synchronization signal;

The acquisition device determines the measured blood pressure based on the PTT.

With reference to the first aspect, the first aspect of the first aspect to the third possible implementation manner of the first aspect, in a fourth possible implementation manner of the first aspect, the acquiring device is configured according to the actual measurement Blood pressure and a predictive equation for determining predicted blood pressure, correcting the coefficients of the predictive equation, including:

The acquiring device performs second differential differentiation on the light volume change trace pulse signal to obtain a feature quantity;

The acquiring device obtains a predicted blood pressure according to the feature quantity and a preset estimation equation;

The acquiring device corrects coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

In a second aspect, an embodiment of the present invention provides a method for continuous blood pressure measurement, including:

Receiving side device acquires ECG signal and light volume change trace pulse signal;

The receiving side device determines the measured blood pressure according to the electrocardiographic signal and the light volume change tracing pulse signal;

Transmitting, by the receiving device, the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.

In a third aspect, an embodiment of the present invention provides a method for continuous blood pressure measurement, including:

The transmitting device acquires a light volume change trace pulse signal, and transmits the light volume change trace pulse signal to the receiving side device, so that the receiving side device determines the pulse signal according to the acquired ECG signal and the light volume change trace signal Measured blood pressure;

Receiving, by the transmitting device, the measured blood pressure sent by the receiving device;

The transmitting device corrects the coefficients of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.

In a fourth aspect, an embodiment of the present invention provides a continuous blood pressure measuring device, including:

Obtaining a module for acquiring an electrocardiographic signal and a light volume change trace pulse signal;

a determining module, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;

And a processing module, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

With reference to the fourth aspect, in a first possible implementation manner of the fourth aspect, the acquiring module includes:

a first collecting unit, configured to collect a heart wave through the ECG sensor;

a first processing unit, configured to perform fast Fourier transform FFT processing on the ECG to obtain a processing signal;

The first processing unit is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.

In combination with the fourth aspect or the first possible implementation of the fourth aspect, the second aspect of the fourth aspect In a possible implementation manner, the acquiring module includes:

a second collecting unit, configured to collect a pulse wave by using a pulse sensor;

a second processing unit, configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;

The second processing unit is configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.

With reference to the fourth aspect, the second any one of the first to fourth aspects of the fourth aspect, in a third possible implementation manner of the fourth aspect, the determining module includes:

a synchronization unit, configured to synchronize the electrocardiographic signal and the optical volume change trace pulse signal to obtain a synchronization signal;

a calculating unit, configured to calculate a pulse transmission time PTT according to the synchronization signal;

a determining unit configured to determine the measured blood pressure based on the PTT.

With reference to the fourth aspect, the third any one of the first to fourth aspects of the fourth aspect, in a fourth possible implementation manner of the fourth aspect, the processing module includes:

An acquiring unit, configured to perform second differential differentiation on the light volume change pulse signal to obtain a feature quantity;

The acquiring unit is configured to obtain a predicted blood pressure according to the feature quantity and a preset prediction equation;

And a correcting unit, configured to correct a coefficient of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

In a fifth aspect, an embodiment of the present invention provides a device for continuous blood pressure measurement, including:

Obtaining a module for acquiring an electrocardiographic signal and a light volume change trace pulse signal;

a determining module, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;

a sending module, configured to send the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.

In a sixth aspect, an embodiment of the present invention provides a device for continuous blood pressure measurement, including:

Obtaining a module for acquiring a light volume change trace pulse signal;

a sending module, configured to send the light volume change trace pulse signal to the receiving side device, to And determining, by the receiving device, the measured blood pressure according to the acquired ECG signal and the light volume change tracing pulse signal;

a receiving module, configured to receive the measured blood pressure sent by the receiving device;

And a processing module, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

In a seventh aspect, an embodiment of the present invention provides an acquiring device, including:

a receiver for acquiring an electrocardiographic signal and a light volume change trace pulse signal;

a processor, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;

The processor is further configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

With reference to the seventh aspect, in a first possible implementation manner of the seventh aspect, the receiver is further configured to collect an ECG wave by using an ECG sensor;

The processor is further configured to perform fast Fourier transform FFT processing on the ECG to obtain a processing signal;

The processor is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.

With reference to the seventh aspect, or the first possible implementation manner of the seventh aspect, in a second possible implementation manner of the seventh aspect, the receiver is further configured to collect a pulse wave by using a pulse sensor;

The processor is further configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;

The processor is further configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.

With reference to the seventh aspect, the second possible implementation manner of the first to seventh aspects of the seventh aspect, in a third possible implementation manner of the seventh aspect, the processor is further configured to: Synchronizing the electrocardiographic signal with the photometric volume change pulse signal to obtain a synchronization signal;

The processor is further configured to calculate a pulse transmission time PTT according to the synchronization signal;

The processor is further configured to determine the measured blood pressure according to the PTT.

With reference to the seventh aspect, the third possible implementation manner of the first to seventh aspects of the seventh aspect, in a fourth possible implementation manner of the seventh aspect, the processor is further configured to Light volume The variation traces the pulse signal for secondary differentiation to obtain a feature quantity;

The processor is further configured to obtain a predicted blood pressure according to the feature quantity and a preset estimation equation;

The processor is further configured to correct coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

The eighth aspect of the present invention provides a receiving device, including:

a receiver for acquiring an electrocardiographic signal and a light volume change trace pulse signal;

a processor, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;

a transmitter, configured to send the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.

A ninth aspect, the embodiment of the present invention provides a sending side device, including:

a receiver for acquiring a light volume change trace pulse signal;

a transmitter, configured to send the light volume change trace pulse signal to the receiving side device, wherein the receiving side device determines the measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;

The receiver is configured to receive the measured blood pressure sent by the receiving device;

And a processor, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.

The method, device and device for measuring continuous blood pressure according to embodiments of the present invention, the acquiring device acquires an electrocardiographic signal and a light volume change pulse signal, and determines a measured blood pressure according to the pulse signal of the electrocardiogram signal and the light volume change, and determines the blood pressure according to the measured blood pressure and the measured blood pressure. The estimation equation is used to correct the coefficients of the prediction equation and calculate the blood pressure value according to the corrected prediction equation. Since the blood pressure is predicted by the pulse signal according to the relevant parameters related to blood pressure and the light volume change after obtaining the measured blood pressure, and the coefficient of the prediction equation for determining the predicted blood pressure is corrected by the measured blood pressure, and according to the corrected estimation equation The blood pressure value is calculated, thereby improving the accuracy of continuously measuring blood pressure.

DRAWINGS

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below. Obviously, the drawings in the following description are only It is a certain embodiment of the present invention, and other drawings can be obtained from those skilled in the art without any creative work.

1 is a schematic flow chart of Embodiment 1 of a continuous blood pressure measurement method according to the present invention;

2 is a schematic flow chart of Embodiment 2 of a continuous blood pressure measurement method according to the present invention;

3 is a schematic flow chart of a third embodiment of a continuous blood pressure measurement method according to the present invention;

4 is a schematic flow chart of Embodiment 4 of a continuous blood pressure measurement method according to the present invention;

5 is a schematic flow chart of Embodiment 5 of a continuous blood pressure measurement method according to the present invention;

6 is a schematic flow chart of Embodiment 6 of a continuous blood pressure measurement method according to the present invention;

7 is a schematic flow chart of Embodiment 7 of a continuous blood pressure measurement method according to the present invention;

Figure 8 is a schematic structural view of a first embodiment of a continuous blood pressure measuring device according to the present invention;

9 is a schematic structural view of a second embodiment of a continuous blood pressure measuring device according to the present invention;

10 is a schematic structural view of a third embodiment of a continuous blood pressure measuring device according to the present invention;

11 is a schematic structural view of a fourth embodiment of a continuous blood pressure measuring device according to the present invention;

12 is a schematic structural view of a fifth embodiment of a continuous blood pressure measuring device according to the present invention;

Figure 13 is a schematic structural view of Embodiment 6 of the continuous blood pressure measuring device of the present invention;

FIG. 14 is a schematic structural diagram of Embodiment 1 of an acquiring device according to the present invention;

15 is a schematic structural diagram of Embodiment 1 of a receiving device according to the present invention;

FIG. 16 is a schematic structural diagram of Embodiment 1 of a transmitting device according to the present invention.

detailed description

The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, but not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts are within the scope of the present invention.

1 is a schematic flow chart of Embodiment 1 of a continuous blood pressure measurement method according to the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs a continuous blood pressure measurement method, which may be implemented by software and/or hardware. In this embodiment, the device may be integrated in the acquiring device, wherein the acquiring device may be, for example, a mobile terminal or a wearable device. As shown in FIG. 1, the method in this embodiment may include:

Step 101: The acquiring device acquires an electrocardiographic signal and a light volume change trace pulse signal.

In this embodiment, the acquiring device acquires the ECG signal through the ECG sensor, and acquires the light volume change trace pulse signal through the pulse sensor, wherein the ECG sensor can be, for example, an ECG electrode. In practical applications, the ECG signals are obtained by placing at least two ECG electrodes at different positions of the acquisition device. For example, at least two ECG electrodes can be placed at positions where the left and right hands of the user can be respectively contacted to obtain through the ECG electrodes. User's ECG signal. The number of the ECG electrodes and the specific placement position are not limited by the present invention.

Step 102: The acquiring device determines the measured blood pressure according to the electrocardiographic signal and the light volume change tracing pulse signal.

In this embodiment, after acquiring the ECG signal and the light volume change pulse signal, the acquiring device traces the pulse signal according to the ECG signal and the light volume change, and jointly determines the measured blood pressure of the user.

Step 103: The acquiring device corrects the coefficient of the prediction equation according to the measured blood pressure value and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.

In this embodiment, the establishment of the prediction equation requires machine learning in advance in conjunction with the input data. Wherein, the input data is a blood pressure-related parameter, which includes at least one of the following: sex, weight, height, daily pulse, living habits, work schedule, electrocardiogram characteristics, medication status, light volume change, pulse pulse velocity pulse, acceleration Pulse and so on. In the specific implementation process, the pulse signal can be classified according to each parameter, and then the multivariate regression analysis is performed on the pulse signal of the classified light volume to obtain the relationship between each parameter and blood pressure, thereby determining The most suitable predictive equation, for example: when performing machine learning, classify the light volume change pulse signal according to the user's medication status, and if the user does not take the medicine, continue to classify according to the user's age... and finally, The light volume change pulse signal is divided into N categories. After classification, multiple regression analysis is performed on the pulse signal of the light volume change according to the classification result, and the relationship between each parameter and blood pressure is obtained, thereby obtaining the estimation equation. The predictive equation for calculating the predicted blood pressure is: sBPe = f(t, Ci), where sBPe is the predicted blood pressure, t is the characteristic quantity, and Ci is the random factor, which is used to adjust the regression effect.

Wherein, for the feature quantity, the acquiring device may acquire the pulse signal by performing a differential operation on the light volume change trace signal after acquiring the light volume change trace pulse signal. In a specific implementation process, the feature quantity can be obtained by performing differential differentiation on the pulse volume signal of the light volume change. Wherein, after the light volume change trace pulse signal is differentiated once, the speed pulse can be obtained, and then after the second differential, the acceleration pulse can be known, and then the feature quantity can be known.

Further, after the acquisition device obtains the feature amount, the predicted blood pressure can be calculated based on the estimation equation for calculating the predicted blood pressure determined by machine learning in advance.

In a specific implementation process, as described above, the light volume change trace pulse signal is classified according to the input data, and then the multivariate regression analysis is performed on the classified light volume change pulse signal, and accordingly, the obtained estimation equation is also obtained. There will be several groups (n), and which set of predictive equations to use for this blood pressure prediction is determined based on the measured blood pressure determined by the acquisition device. Specifically, the measured blood pressure can be taken as the average value X, and the calculated predicted blood pressure is assumed to be X i , where i is the predicted number of blood pressures (the number of samples), and the measured blood pressure X and the predicted blood pressure X i (sample) are calculated. The standard deviation between S n . Iteration uses all n groups estimate equation, standard deviation S n to obtain blood samples and prediction of X, if the calculated predicted blood j-th standard deviation S j corresponding to the minimum of all of n S n groups, selecting the The group prediction equation (with a standard deviation of S j ) is used for the measurement, where j is less than or equal to i. For multivariate regression analysis, other models may also be used, which are not limited by the present invention.

According to the continuous blood pressure measuring method provided by the embodiment of the present invention, the acquiring device acquires the electrocardiogram signal and the light volume change trace pulse signal, and determines the measured blood pressure according to the pulse signal of the electrocardiogram signal and the light volume change, and determines the predicted blood pressure based on the measured blood pressure and the predicted blood pressure. The error correction is performed on the coefficients of the prediction equation, and the blood pressure value is calculated according to the corrected prediction equation. Since the blood pressure is predicted by the pulse signal according to the relevant parameters related to blood pressure and the light volume change after obtaining the measured blood pressure, and the coefficient of the prediction equation for determining the predicted blood pressure is corrected by the measured blood pressure, and according to the corrected estimation equation The blood pressure value is calculated, thereby improving the accuracy of continuous blood pressure measurement.

2 is a schematic flow chart of the second embodiment of the continuous blood pressure measurement method of the present invention. The embodiment of the present invention is based on the first embodiment of the continuous blood pressure measurement method, and the embodiment for acquiring the ECG signal by the acquisition device is described in detail. As shown in FIG. 2, the method in this embodiment may include:

Step 201: The acquiring device collects the ECG wave through the ECG sensor.

In this embodiment, the ECG wave acquired by the acquisition device is a non-processed and processed timing signal.

Step 202: The acquiring device performs fast Fourier transform FFT processing on the electrocardiogram to obtain a processed signal.

In this embodiment, the acquisition device uses the signal processing circuit to perform A/D conversion and fast on the electrocardiogram. The Fast Fourier Transform (FFT) process transforms the time domain signal into a frequency domain signal to facilitate signal analysis and processing.

Step 203: The acquiring device performs noise removal processing on the processed signal to obtain an ECG signal.

In this embodiment, after the acquisition device detects the peak waveform of the electrocardiogram in the obtained processed signal, the noise removal processing is performed, wherein the noise removal mainly adopts a method of filtering the signal, for example, an acceleration sensor may be adopted. When the motion mode is detected, then the frequency domain signal fluctuation of the ECG sensor is compared to eliminate the noise introduced due to motion or the like.

According to the continuous blood pressure measuring method provided by the embodiment of the invention, the acquiring device collects the ECG wave through the ECG sensor, processes the ECG wave, obtains the processing signal, and then performs noise removal processing on the processed signal to obtain the ECG signal, thereby improving the ECG signal. The accuracy of ECG signal measurement.

3 is a schematic flow chart of a third embodiment of a continuous blood pressure measurement method according to the present invention. This embodiment is based on the embodiment shown in FIG. 1 or FIG. 2, and an embodiment of acquiring a light volume change pulse signal by an acquisition device is described in detail. . As shown in FIG. 3, the method in this embodiment may include:

Step 301: The acquiring device collects a pulse wave by using a pulse sensor.

In this embodiment, the pulse wave acquired by the acquisition device is a non-processed and processed timing signal.

Step 302: The acquiring device performs fast Fourier transform FFT processing on the pulse wave to obtain a processed signal.

In this embodiment, the acquiring device uses the signal processing circuit to perform A/D conversion on the pulse wave, and performs FFT processing on the converted signal, thereby converting the time domain signal into a frequency domain signal to facilitate signal analysis and processing.

Step 303: The acquiring device performs noise removal processing on the processed signal to obtain a light volume change trace pulse signal.

In this embodiment, after the acquisition device detects the peak waveform of the pulse in the obtained processed signal, the noise removal process is performed. The noise removal mainly adopts a method of filtering the signal, for example, an acceleration sensor or the like. The motion mode is detected, and then the frequency domain signal fluctuation of the pulse sensor is compared to eliminate noise introduced due to motion or the like.

According to the continuous blood pressure measurement method provided by the embodiment of the present invention, the acquiring device collects the pulse wave through the pulse sensor, processes the pulse wave, obtains the processing signal, and then performs noise removal processing on the processed signal to obtain a light volume change trace pulse signal. Improves the accuracy of light volume measurement trace pulse signal measurement. In addition, the pulse signal is measured by the pulse sensor to measure the pulse signal. The purpose of continuous measurement.

4 is a schematic flow chart of the fourth embodiment of the method for measuring continuous blood pressure according to the present invention. On the basis of the above embodiments, the embodiment obtains an example of determining the measured blood pressure according to the pulse signal of the ECG signal and the light volume change. Description. As shown in FIG. 4, the method in this embodiment may include:

Step 401: The acquiring device synchronizes the electrocardiographic signal and the optical volume change trace pulse signal to obtain a synchronization signal.

In this embodiment, since the electrocardiographic signal is measured by the electrocardiographic sensor, and the optical volume change trace signal is measured by the pulse sensor, it is necessary to synchronize the two signals to find the same electrocardiogram. The R wave and the rising point of the pulse to calculate the time difference between the R wave and the rising point of the pulse. In a specific implementation process, the synchronization time of the ECG signal and the pulse volume can be synchronized by synchronizing the acquisition time of the ECG sensor and the pulse sensor.

Step 402: The acquiring device calculates a pulse transmission time PTT according to the synchronization signal.

In this embodiment, assuming that the contraction of the heart and the blood pumping are simultaneous, the pulse transit time (PTT) can be calculated by the time difference between the R wave of the electrocardiogram and the rising point of the pulse. Ground, assuming time a represents the position of the R wave apex on the ECG signal on the time axis, time b and time c respectively represent the position of a bottom point on the pulse signal and the position of a vertex on the time axis, respectively. The PTT can be obtained by calculating the time difference between the time a and the time b, and the PTT can be obtained by calculating the time difference between the time a and the time c. For the method for calculating the PTT, the embodiment is not limited herein.

Step 403: The acquiring device determines the measured blood pressure according to the PTT.

In this embodiment, after the acquiring device calculates the PTT, according to the formula

Figure PCTCN2015079914-appb-000001
The measured blood pressure value P s can be calculated, wherein b 1 , b 2 and b 3 are coefficients respectively, which are related to blood vessel elasticity and motion, and T PTT is the pulse propagation speed.

According to the continuous blood pressure measuring method provided by the embodiment of the present invention, the acquiring device traces the pulse signal by acquiring the ECG signal and the light volume change, and determines the measured blood pressure according to the pulse signal of the ECG signal and the light volume change, and estimates the predicted blood pressure according to the measured blood pressure and the measured blood pressure. The equation corrects the coefficients of the predictive equation and calculates the blood pressure value based on the corrected predictive equation. Due to the actual measurement After the blood pressure, the acquisition device predicts the blood pressure based on the relevant parameters related to the blood pressure and the light volume change, and corrects the coefficient of the predicted equation for estimating the predicted blood pressure by using the measured blood pressure, thereby improving the accuracy of the continuous blood pressure measurement. In addition, the acquisition device can determine the measured blood pressure in combination with the measured light volume change pulse signal without adding additional hardware, simplifying the complexity of the blood pressure measuring device, reducing the cost, and ensuring the accuracy of the continuous blood pressure detection. .

FIG. 5 is a schematic flow chart of Embodiment 5 of the method for measuring continuous blood pressure according to the present invention. On the basis of the above embodiments, the present embodiment performs the estimation equation of the estimation equation according to the estimated equation of the blood pressure and the determined blood pressure. The corrected embodiment will be described in detail. As shown in FIG. 5, the method in this embodiment may include:

Step 501: The acquiring device performs second differential differentiation on the light volume change trace pulse signal to obtain a feature quantity.

In this embodiment, the acquiring device may acquire the feature quantity by performing a differential operation on the light volume change trace pulse signal after acquiring the light volume change trace pulse signal. In a specific implementation process, the pulse signal can be obtained by performing two differential differentiations on the light volume change trace. After the light volume change trace pulse signal is differentiated once, the speed pulse can be obtained, and then the second differential can be performed. The acceleration pulse is known, and then the feature quantity can be obtained.

Step 502: The acquiring device obtains the predicted blood pressure according to the feature quantity and the preset prediction equation.

In the present embodiment, after the acquisition device obtains the feature amount, the predicted blood pressure can be calculated based on the prediction equation for calculating the predicted blood pressure determined by machine learning in advance.

Step 503: The acquiring device corrects the coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

In this embodiment, after calculating the predicted blood pressure, the acquiring device may perform a multiple regression analysis in combination with the determined measured blood pressure (eg, systolic blood pressure) to correct the coefficient of the predictive equation for calculating the predicted blood pressure, wherein, Multiple regression analysis can use a linear regression model in which the parameters related to blood pressure are determined by least squares estimation to determine the coefficients of the prediction equation. In the specific implementation process, the light volume change trace pulse signal is classified according to the input data, and after the multivariate regression analysis is performed on the classified light volume change pulse signal, the obtained estimation equation has several groups (n). The prediction of this blood pressure using which set of predictive equations is based on the measured blood pressure sent by the receiving device. Specifically, the measured blood pressure can be taken as the average value X, and the predicted blood pressure calculated by the pseudo design is X i , where i is the number of predicted blood pressures (the number of samples), and the measured blood pressure X and the predicted blood pressure X i (sample) are calculated. The standard deviation between S n . Iteration uses all n groups estimate equation, standard deviation S n to obtain blood samples and prediction of X, if the calculated predicted blood j-th standard deviation S j corresponding to the minimum of all of n S n groups, selecting the The group prediction equation (with a standard deviation of S j ) is used for the measurement, where j is less than or equal to i. For multivariate regression analysis, other models may also be used, which are not limited by the present invention.

According to the continuous blood pressure measuring method provided by the embodiment of the present invention, the acquiring device traces the pulse signal by acquiring the ECG signal and the light volume change, and determines the measured blood pressure according to the pulse signal of the ECG signal and the light volume change, and estimates the predicted blood pressure according to the measured blood pressure and the measured blood pressure. The equation corrects the coefficients of the predictive equation and calculates the blood pressure value based on the corrected predictive equation. Since the acquisition device predicts the blood pressure based on the relevant parameters related to blood pressure and the light volume change after the measured blood pressure is obtained, and corrects the coefficient of the estimated equation for estimating the predicted blood pressure by using the measured blood pressure, the continuous blood pressure measurement is improved. Accuracy.

FIG. 6 is a schematic flow chart of Embodiment 6 of a continuous blood pressure measurement method according to the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs a continuous blood pressure measurement method, which may be implemented by software and/or hardware. In this embodiment, the device can be integrated in the receiving side device. As shown in FIG. 6, the method in this embodiment may include:

Step 601: The receiving side device acquires an electrocardiographic signal and a light volume change trace pulse signal.

In this embodiment, the ECG signal and the optical volume change pulse signal can also be acquired by the receiving device, wherein the receiving device can be various mobile terminals, such as a mobile phone, a PAD, etc., and the receiving device can pass the ECG sensor. To obtain an ECG signal, and to obtain a light volume change trace pulse signal through a pulse sensor.

Step 602: The receiving device determines the measured blood pressure according to the electrocardiographic signal and the light volume change tracing pulse signal.

In this embodiment, after the receiving side device acquires the electrocardiographic signal and the optical volume change trace pulse signal, the pulse signal is traced according to the electrocardiographic signal and the light volume change, and the measured blood pressure of the user is jointly determined.

Step 603: The receiving device sends the measured blood pressure to the transmitting device, so that the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure according to the corrected prediction equation. value.

In this embodiment, the transmitting device may be any device having a pulse signal for collecting light volume change, such as a smart bracelet, a smart watch, or the like. After the receiving device determines the measured blood pressure, the measured blood pressure is transmitted to the transmitting device through Bluetooth Low Energy (BLE), and the transmitting device can perform the pre-measure based on the measured blood pressure and the preset prediction equation. The coefficient of the equation is estimated to be corrected, and after the correction is completed, the blood pressure value is calculated based on the corrected prediction equation.

According to the continuous blood pressure measuring method provided by the embodiment of the present invention, the receiving side device traces the pulse signal by acquiring the electrocardiographic signal and the light volume change, determines the measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal, and transmits the measured blood pressure to the transmitting side device. For the transmitting side device to correct the coefficient of the prediction equation according to the measured blood pressure and the estimation equation for determining the predicted blood pressure, and calculate the blood pressure value according to the corrected prediction equation. Since the transmitting side device predicts the blood pressure according to the blood pressure related parameter and the light volume change after the obtained measured blood pressure is obtained, and the measured blood pressure is used to correct the coefficient of the predicted equation for determining the predicted blood pressure, and according to the corrected The predictive equation calculates the blood pressure value, which improves the accuracy of continuous blood pressure measurement.

FIG. 7 is a schematic flow chart of Embodiment 7 of a continuous blood pressure measurement method according to the present invention. Embodiments of the present invention provide a continuous blood pressure measurement method, which may be performed by any device that performs a continuous blood pressure measurement method, which may be implemented by software and/or hardware. In this embodiment, the device can be integrated in the transmitting device. As shown in FIG. 7, the method in this embodiment may include:

Step 701: The transmitting device acquires a light volume change trace pulse signal, and sends the light volume change trace pulse signal to the receiving side device, so that the receiving side device determines the measured blood pressure according to the acquired ECG signal and the light volume change trace pulse signal.

In this embodiment, the transmitting device may be any device having a pulse signal for collecting light volume change, such as a smart bracelet, a smart watch, or the like. After the transmitting side device acquires the pulse signal through the pulse sensor, it does not perform any processing on the light volume change trace pulse signal, but directly transmits it to the receiving side device through BLE, and the receiving side device traces the pulse signal according to the received light volume change. The ECG signal obtained by itself can determine the measured blood pressure of the user. The receiving side device may be various mobile terminals, and obtain the ECG signal of the user by placing the ECG electrodes at different positions of the receiving side device.

Step 702: The transmitting device receives the measured blood pressure sent by the receiving device.

Step 703: The transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.

In the present embodiment, the establishment of the estimation equation of the transmitting-side device requires machine learning in advance in conjunction with the input data. Wherein, the input data is a blood pressure-related parameter, which includes at least one of the following: sex, weight, height, daily pulse, living habits, work schedule, electrocardiogram characteristics, medication status, light volume change, pulse pulse velocity pulse, acceleration Pulse and so on. In the specific implementation process, the pulse signal can be classified according to each parameter, and then the multivariate regression analysis is performed on the pulse signal of the classified light volume to obtain the relationship between each parameter and blood pressure, thereby determining The most suitable predictive equation, for example: when performing machine learning, classify the light volume change pulse signal according to the user's medication status, and if the user does not take the medicine, continue to classify according to the user's age... and finally, The light volume change pulse signal is divided into N categories. After classification, multiple regression analysis is performed on the pulse signal of the light volume change according to the classification result, and the relationship between each parameter and blood pressure is obtained, thereby obtaining the estimation equation. The calculation formula for predicting blood pressure is: sBPe=f(t,Ci), where sBPe is the predicted blood pressure, t is the characteristic quantity, Ci is the random factor, and Ci is used to adjust the regression effect.

Wherein, for the feature quantity, the speed pulse, and the acceleration pulse, the transmitting device may acquire the pulse signal by performing a differential operation on the light volume change trace signal after acquiring the light volume change trace signal. In a specific implementation process, the feature quantity can be obtained by performing differential differentiation on the pulse volume signal of the light volume change, wherein after the light volume change trace pulse signal is differentiated once, the velocity pulse can be obtained, and then the second differential is performed. , you can know the acceleration pulse.

The transmitting device calculates the predicted blood pressure according to the determined prediction equation, and corrects the coefficient of the prediction equation according to the received measured blood pressure and the calculated predicted blood pressure. After the correction is completed, the corrected estimated equation is calculated. Blood pressure value.

According to the continuous blood pressure measuring method provided by the embodiment of the present invention, the transmitting device acquires the optical volume change trace pulse signal, and sends the optical volume change trace pulse signal to the receiving side device, so that the receiving side device changes according to the acquired ECG signal and the light volume. The pulse signal is determined to determine the measured blood pressure, and the measured blood pressure sent by the receiving device is received, and the coefficients of the preset prediction equation are corrected according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and are calculated according to the corrected prediction equation. Blood pressure value. Since the transmitting side device corrects the coefficient of the prediction equation according to the measured blood pressure to obtain the blood pressure value after obtaining the measured blood pressure, the accuracy of the continuous blood pressure measurement can be improved.

FIG. 8 is a schematic structural view of a first embodiment of a continuous blood pressure measuring device according to the present invention. As shown in FIG. 8 , the continuous blood pressure measuring device provided by the embodiment of the present invention includes an obtaining module 11 and a determining module 12 and Module 13.

The obtaining module 11 is configured to acquire an electrocardiographic signal and a light volume change trace pulse signal; the determining module 12 is configured to determine the measured blood pressure according to the ECG signal and the light volume change trace pulse signal; and the processing module 13 is configured to The measured blood pressure is determined and the predictive equation for predicting the predicted blood pressure is corrected, the coefficients of the predictive equation are corrected, and the blood pressure value is calculated according to the corrected predictive equation.

According to the continuous blood pressure measuring device provided by the embodiment of the present invention, the acquiring device acquires the electrocardiogram signal and the light volume change trace pulse signal, and determines the measured blood pressure according to the pulse signal of the electrocardiogram signal and the light volume change, and determines the predicted blood pressure based on the measured blood pressure and the predicted blood pressure. The error correction is performed on the coefficients of the prediction equation, and the blood pressure value is calculated according to the corrected prediction equation. Since the blood pressure is predicted by the pulse signal according to the relevant parameters related to blood pressure and the light volume change after obtaining the measured blood pressure, and the coefficient of the prediction equation for determining the predicted blood pressure is corrected by the measured blood pressure, and according to the corrected estimation equation The blood pressure value is calculated, thereby improving the accuracy of continuously measuring blood pressure.

FIG. 9 is a schematic structural diagram of a second embodiment of a continuous blood pressure measuring device according to the present invention. As shown in FIG. 9, the present embodiment is based on the embodiment shown in FIG.

The first collecting unit 111 is configured to collect an ECG wave through the ECG sensor;

The first processing unit 112 is configured to perform fast Fourier transform FFT processing on the ECG to obtain a processing signal;

The first processing unit 112 is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.

The device for continuous blood pressure measurement of the present embodiment can be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects are similar, and details are not described herein again.

10 is a schematic structural diagram of a third embodiment of a continuous blood pressure measuring device according to the present invention. As shown in FIG. 10, the present embodiment is based on the foregoing embodiments, and the acquiring module 11 includes:

The second collecting unit 113 is configured to collect a pulse wave by using a pulse sensor;

The second processing unit 114 is configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;

The second processing unit 114 is configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.

The apparatus for continuous blood pressure measurement of the present embodiment can be used to perform the implementation of any embodiment of the present invention. The technical solution of the method for continuous blood pressure measurement is similar in its implementation principle and technical effects, and details are not described herein again.

FIG. 11 is a schematic structural diagram of Embodiment 4 of a continuous blood pressure measuring device according to the present invention. As shown in FIG. 11, the present embodiment is based on the foregoing embodiments, and the determining module 12 includes:

The synchronization unit 121 is configured to synchronize the ECG signal and the optical volume change trace pulse signal to obtain a synchronization signal;

The calculating unit 122 is configured to calculate a pulse transmission time PTT according to the synchronization signal;

The determining unit 123 is configured to determine the measured blood pressure based on the PTT.

Optionally, the processing module 13 includes:

The obtaining unit 131 is configured to perform second differential differentiation on the light volume change trace pulse signal to obtain a feature quantity;

The obtaining unit 131 is configured to obtain a predicted blood pressure according to the feature quantity and a preset prediction equation;

The correcting unit 132 is configured to correct the coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

The device for continuous blood pressure measurement of the present embodiment can be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects are similar, and details are not described herein again.

12 is a schematic structural diagram of Embodiment 5 of the continuous blood pressure measuring device of the present invention. As shown in FIG. 12, the continuous blood pressure measuring device provided by the embodiment of the present invention includes an obtaining module 21, a determining module 22 and a transmitting module 23.

The obtaining module 21 is configured to acquire an electrocardiographic signal and a light volume change trace pulse signal; the determining module 22 is configured to determine the measured blood pressure according to the electrocardiographic signal and the optical volume change trace pulse signal; and the sending module 23 is configured to send to the transmitting side The device sends the measured blood pressure for the transmitting device to correct the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculate the blood pressure value according to the corrected prediction equation .

According to the continuous blood pressure measuring device provided by the embodiment of the present invention, the receiving side device traces the pulse signal by acquiring the electrocardiographic signal and the light volume change, determines the measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal, and transmits the measured blood pressure to the transmitting side device. For the transmitting side device to correct the coefficient of the prediction equation according to the measured blood pressure and the estimation equation for determining the predicted blood pressure, and according to the school The positive predictive equation calculates the blood pressure value. Since the transmitting side device predicts the blood pressure according to the blood pressure related parameter and the light volume change after the obtained measured blood pressure is obtained, and the measured blood pressure is used to correct the coefficient of the predicted equation for determining the predicted blood pressure, and according to the corrected The predictive equation calculates the blood pressure value, which improves the accuracy of continuous blood pressure measurement.

FIG. 13 is a schematic structural diagram of Embodiment 6 of the continuous blood pressure measuring device of the present invention. As shown in FIG. 13 , the continuous blood pressure measuring device provided by the embodiment of the present invention includes an obtaining module 31, a transmitting module 32, a receiving module 33, and a processing module 34.

The obtaining module 31 is configured to acquire a light volume change trace pulse signal, and the sending module 32 is configured to send the light volume change trace pulse signal to the receiving side device, so that the receiving side device can obtain the ECG signal according to the acquired The light volume change trace pulse signal determines the measured blood pressure; the receiving module 33 is configured to receive the measured blood pressure sent by the receiving side device; the processing module 34 is configured to calculate the predicted blood pressure according to the measured blood pressure and the predicted equation for predicting the blood pressure. The coefficients of the equation are estimated to be corrected, and the blood pressure value is calculated based on the corrected prediction equation.

According to the continuous blood pressure measuring device provided by the embodiment of the present invention, the transmitting device acquires the optical volume change trace pulse signal, and transmits the optical volume change trace pulse signal to the receiving side device, so that the receiving side device changes according to the acquired ECG signal and the light volume. The pulse signal is determined to determine the measured blood pressure, and the measured blood pressure sent by the receiving device is received, and the coefficients of the preset prediction equation are corrected according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and are calculated according to the corrected prediction equation. Blood pressure value. Since the transmitting side device corrects the coefficient of the prediction equation according to the measured blood pressure to obtain the blood pressure value after obtaining the measured blood pressure, the accuracy of the continuous blood pressure measurement can be improved.

FIG. 14 is a schematic structural diagram of Embodiment 1 of the acquiring device of the present invention. As shown in FIG. 14, the acquiring device provided by the embodiment of the present invention includes a receiver 41 and a processor 42.

The receiver 41 is configured to acquire an electrocardiographic signal and a light volume change trace pulse signal; the processor 42 is configured to determine the measured blood pressure according to the ECG signal and the light volume change trace pulse signal; the processor 42 is further configured to: Based on the measured blood pressure and a prediction equation for determining the predicted blood pressure, the coefficients of the predictive equation are corrected, and the blood pressure value is calculated according to the corrected predictive equation.

The obtaining device provided in this embodiment can be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects thereof are similar, and details are not described herein again.

Optionally, the receiver 41 is further configured to collect an ECG wave through the ECG sensor;

The processor 42 is further configured to perform fast Fourier transform FFT processing on the ECG wave. Have to process the signal;

The processor 42 is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.

Optionally, the receiver 41 is further configured to collect a pulse wave by using a pulse sensor;

The processor 42 is further configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;

The processor 42 is further configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.

Optionally, the processor 42 is further configured to synchronize the ECG signal and the optical volume change trace pulse signal to obtain a synchronization signal;

The processor 42 is further configured to calculate a pulse transmission time PTT according to the synchronization signal;

The processor 42 is further configured to determine the measured blood pressure based on the PTT.

The processor 42 is further configured to perform second differential differentiation on the optical volume change pulse signal to obtain a feature quantity;

The processor 42 is further configured to obtain a predicted blood pressure according to the feature quantity and a preset estimation equation;

The processor 42 is further configured to correct coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.

The obtaining device provided in this embodiment can be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects thereof are similar, and details are not described herein again.

FIG. 15 is a schematic structural diagram of Embodiment 1 of a receiving device according to the present invention. As shown in FIG. 15, the transmitting device includes a receiver 51, a processor 52, and a transmitter 53.

The receiver 51 is configured to acquire an electrocardiographic signal and a light volume change trace pulse signal; the processor 52 is configured to determine the measured blood pressure according to the ECG signal and the light volume change trace pulse signal; the transmitter 53 is configured to send to the transmitting side device The measured blood pressure is used by the transmitting device to correct the coefficient of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculate the blood pressure value according to the corrected prediction equation.

The obtaining device provided in this embodiment can be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects thereof are similar, and details are not described herein again.

FIG. 16 is a schematic structural diagram of Embodiment 1 of a transmitting device according to the present invention, as shown in FIG. The transmitting side device provided by the embodiment includes a receiver 61, a transmitter 62, and a processor 63.

The receiver 61 is configured to acquire a light volume change trace pulse signal; the transmitter 62 is configured to send the light volume change trace pulse signal to the receiving side device, where the receiving side device is configured according to the ECG signal and the light The volume change trace pulse signal determines the measured blood pressure; the receiver 61 is configured to receive the measured blood pressure sent by the receiving side device; the processor 63 is configured to determine, according to the measured blood pressure and the predicted equation for predicting the blood pressure, The coefficients of the prediction equation are corrected, and the blood pressure value is calculated according to the corrected prediction equation.

The transmitting side device provided in this embodiment may be used to implement the technical solution of the method for continuous blood pressure measurement provided by any embodiment of the present invention, and the implementation principle and technical effects thereof are similar, and details are not described herein again.

It will be clearly understood by those skilled in the art that for the convenience and brevity of the description, only the division of each functional module described above is exemplified. In practical applications, the above function assignment can be completed by different functional modules as needed. The internal structure of the device is divided into different functional modules to perform all or part of the functions described above. For the specific working process of the system, the device and the unit described above, reference may be made to the corresponding process in the foregoing method embodiments, and details are not described herein again.

In the several embodiments provided by the present application, it should be understood that the disclosed system, apparatus, and method may be implemented in other manners. For example, the device embodiments described above are merely illustrative. For example, the division of the modules or units is only a logical function division. In actual implementation, there may be another division manner, for example, multiple units or components may be used. Combinations can be integrated into another system, or some features can be ignored or not executed. In addition, the mutual coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interface, device or unit, and may be in an electrical, mechanical or other form.

The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.

The integrated unit, if implemented in the form of a software functional unit and sold or used as a standalone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present application, in essence or the contribution to the prior art, or all or part of the technical solution may be embodied in the form of a software product stored in a storage medium. A number of instructions are included to cause a computer device (which may be a personal computer, server, or network device, etc.) or a processor to perform all or part of the steps of the methods described in various embodiments of the present application. The foregoing storage medium includes: a U disk, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk, or an optical disk, and the like. .

The above embodiments are only used to explain the technical solutions of the present application, and are not limited thereto; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that they can still The technical solutions described in the embodiments are modified, or the equivalents of the technical features are replaced by the equivalents. The modifications and substitutions of the embodiments do not depart from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims (21)

  1. A continuous blood pressure measuring method, comprising:
    Acquiring the device to obtain an ECG signal and a light volume change trace pulse signal;
    The acquiring device determines the measured blood pressure according to the electrocardiographic signal and the light volume change tracing pulse signal;
    The acquiring device corrects the coefficients of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.
  2. The method according to claim 1, wherein the acquiring device acquires an electrocardiographic signal, comprising:
    The acquiring device collects an ECG wave through an ECG sensor;
    Performing fast Fourier transform FFT processing on the ECG to obtain a processing signal;
    The acquiring device performs noise removal processing on the processed signal to obtain the ECG signal.
  3. The method according to claim 1 or 2, wherein the acquiring device acquires a light volume change trace pulse signal, comprising:
    The acquiring device collects a pulse wave through a pulse sensor;
    Performing fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;
    The acquiring device performs noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.
  4. The method according to any one of claims 1 to 3, wherein the obtaining device determines the measured blood pressure value according to the electrocardiographic signal and the light volume change trace pulse signal, including:
    The acquiring device synchronizes the electrocardiographic signal and the optical volume change trace pulse signal to obtain a synchronization signal;
    The acquiring device calculates a pulse transmission time PTT according to the synchronization signal;
    The acquisition device determines the measured blood pressure based on the PTT.
  5. The method according to any one of claims 1 to 4, wherein the obtaining means corrects the coefficients of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, including:
    The acquiring device performs second-order differentiation of the light volume change pulse signal to obtain a feature the amount;
    The acquiring device obtains a predicted blood pressure according to the feature quantity and a preset estimation equation;
    The acquiring device corrects coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.
  6. A continuous blood pressure measuring method, comprising:
    Receiving side device acquires ECG signal and light volume change trace pulse signal;
    The receiving side device determines the measured blood pressure according to the electrocardiographic signal and the light volume change tracing pulse signal;
    Transmitting, by the receiving device, the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.
  7. A method of continuous blood pressure measurement, comprising:
    The transmitting device acquires a light volume change trace pulse signal, and transmits the light volume change trace pulse signal to the receiving side device, so that the receiving side device determines the pulse signal according to the acquired ECG signal and the light volume change trace signal Measured blood pressure;
    Receiving, by the transmitting device, the measured blood pressure sent by the receiving device;
    The transmitting device corrects the coefficients of the prediction equation according to the measured blood pressure and the prediction equation for determining the predicted blood pressure, and calculates the blood pressure value according to the corrected prediction equation.
  8. A continuous blood pressure measuring device, comprising:
    Obtaining a module for acquiring an electrocardiographic signal and a light volume change trace pulse signal;
    a determining module, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;
    And a processing module, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.
  9. The device according to claim 8, wherein the obtaining module comprises:
    a first collecting unit, configured to collect a heart wave through the ECG sensor;
    a first processing unit, configured to perform fast Fourier transform FFT processing on the ECG to obtain a processing signal;
    The first processing unit is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.
  10. The device according to claim 8 or 9, wherein the obtaining module comprises:
    a second collecting unit, configured to collect a pulse wave by using a pulse sensor;
    a second processing unit, configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;
    The second processing unit is configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.
  11. The apparatus according to any one of claims 8 to 10, wherein the determining module comprises:
    a synchronization unit, configured to synchronize the electrocardiographic signal and the optical volume change trace pulse signal to obtain a synchronization signal;
    a calculating unit, configured to calculate a pulse transmission time PTT according to the synchronization signal;
    a determining unit configured to determine the measured blood pressure based on the PTT.
  12. The device according to any one of claims 8-11, wherein the processing module comprises:
    An acquiring unit, configured to perform second differential differentiation on the light volume change pulse signal to obtain a feature quantity;
    The acquiring unit is configured to obtain a predicted blood pressure according to the feature quantity and a preset prediction equation;
    And a correcting unit, configured to correct a coefficient of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.
  13. A device for continuous blood pressure measurement, comprising:
    Obtaining a module for acquiring an electrocardiographic signal and a light volume change trace pulse signal;
    a determining module, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;
    a sending module, configured to send the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.
  14. A device for continuous blood pressure measurement, comprising:
    Obtaining a module for acquiring a light volume change trace pulse signal;
    a sending module, configured to send the light volume change trace pulse signal to the receiving side device, to And determining, by the receiving device, the measured blood pressure according to the acquired ECG signal and the light volume change tracing pulse signal;
    a receiving module, configured to receive the measured blood pressure sent by the receiving device;
    And a processing module, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.
  15. An acquisition device, comprising:
    a receiver for acquiring an electrocardiographic signal and a light volume change trace pulse signal;
    a processor, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;
    The processor is further configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.
  16. The acquisition device according to claim 15, wherein
    The receiver is further configured to collect a heart wave through the ECG sensor;
    The processor is further configured to perform fast Fourier transform FFT processing on the ECG to obtain a processing signal;
    The processor is further configured to perform noise removal processing on the processed signal to obtain the ECG signal.
  17. The acquisition device according to claim 15 or 16, wherein
    The receiver is further configured to collect a pulse wave by using a pulse sensor;
    The processor is further configured to perform fast Fourier transform FFT processing on the pulse wave to obtain a processing signal;
    The processor is further configured to perform noise removal processing on the processed signal to obtain the optical volume change trace pulse signal.
  18. The acquisition device according to any one of claims 15-17, wherein
    The processor is further configured to synchronize the ECG signal and the optical volume change trace pulse signal to obtain a synchronization signal;
    The processor is further configured to calculate a pulse transmission time PTT according to the synchronization signal;
    The processor is further configured to determine the measured blood pressure according to the PTT.
  19. The acquisition device according to any one of claims 15 to 18, characterized in that
    The processor is further configured to perform second differential differentiation on the optical volume change pulse signal Characteristic quantity
    The processor is further configured to obtain a predicted blood pressure according to the feature quantity and a preset estimation equation;
    The processor is further configured to correct coefficients of the preset prediction equation according to the measured blood pressure and the predicted blood pressure.
  20. A receiving side device, comprising:
    a receiver for acquiring an electrocardiographic signal and a light volume change trace pulse signal;
    a processor, configured to determine a measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;
    a transmitter, configured to send the measured blood pressure to the transmitting device, where the transmitting device corrects the coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining the predicted blood pressure, and corrects according to the correction The post-estimation equation calculates the blood pressure value.
  21. A transmitting device is characterized in that it comprises:
    a receiver for acquiring a light volume change trace pulse signal;
    a transmitter, configured to send the light volume change trace pulse signal to the receiving side device, wherein the receiving side device determines the measured blood pressure according to the electrocardiographic signal and the light volume change trace pulse signal;
    The receiver is configured to receive the measured blood pressure sent by the receiving device;
    And a processor, configured to correct a coefficient of the prediction equation according to the measured blood pressure and a prediction equation for determining a predicted blood pressure, and calculate a blood pressure value according to the corrected prediction equation.
PCT/CN2015/079914 2015-05-27 2015-05-27 Continuous blood pressure measurement method, apparatus and device WO2016187835A1 (en)

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